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Acute inflammatory response

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https://www.readbyqxmd.com/read/29475100/new-thiazolidinedione-lpsf-gq-2-inhibits-nf%C3%AE%C2%BAb-and-mapk-activation-in-lps-induced-acute-lung-inflammation
#1
Laise Aline Martins Dos Santos, Gabriel Barros Rodrigues, Fernanda Virgínia Barreto Mota, Maria Eduarda Rocha de França, Karla Patrícia de Souza Barbosa, Wilma Helena de Oliveira, Sura Wanessa Santos Rocha, Deniele Bezerra Lós, Amanda Karolina Soares Silva, Teresinha Gonçalves da Silva, Christina Alves Peixoto
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as potential drugs for the treatment of ALI and ARDS due to their anti-inflammatory efficacy. The present study aims to evaluate the potential anti-inflammatory effects of new TZDs derivatives, LPSF/GQ-2 and LPSF/RA-4, on ALI induced by LPS...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29474750/suppressed-heat-shock-protein-response-in-the-kidney-of-exercise-trained-diabetic-rats
#2
J Lappalainen, N K J Oksala, D E Laaksonen, S Khanna, T Kokkola, K Kaarniranta, C K Sen, M Atalay
Impaired expression of heat shock proteins (HSPs) and increased oxidative stress may contribute to the pathophysiology of diabetes by disrupted tissue protection. Acute exercise induces oxidative stress, whereas exercise training up-regulates endogenous antioxidant defenses and HSP expression. Although diabetic nephropathy is a major contributor to diabetic morbidity, information regarding the effect of HSPs on kidney protection is limited. The present study evaluated the effects of 8-week exercise training on kidney HSP expression and markers of oxidative stress at rest and after acute exercise in rats with or without streptozotocin-induced diabetes...
February 23, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29474201/mechanical-ventilation-induces-desensitization-of-lung-axl-tyrosine-kinase-receptors
#3
Gail Otulakowski, Doreen Engelberts, Martin Post, Claire Masterson, Brian P Kavanagh
BACKGROUND: Lower tidal volumes are increasingly used in acute respiratory distress syndrome, but mortality has changed little in the last 20 yr. Therefore, in addition to ventilator settings, it is important to target molecular mediators of injury. Sepsis and other inflammatory states increase circulating concentrations of Gas6, a ligand for the antiinflammatory receptor Axl, and of a soluble decoy form of Axl. We investigated the effects of lung stretch on Axl signaling. METHODS: We used a mouse model of early injury from high tidal volume and assessed the effects of inhibiting Axl on in vivo lung injury (using an antagonist R428, n = 4/group)...
February 23, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29473284/label-free-monitoring-of-inflammatory-tissue-conditions-using-a-carrageenan-induced-acute-inflammation-rat-model
#4
Seung Ho Lee, Sang Hwa Lee, Jae-Ho Shin, Samjin Choi
Although the confirmation of inflammatory changes within tissues at the onset of various diseases is critical for the early detection of disease and selection of appropriate treatment, most therapies are based on complex and time-consuming diagnostic procedures. Raman spectroscopy has the ability to provide non-invasive, real-time, chemical bonding analysis through the inelastic scattering of photons. In this study, we evaluate the feasibility of Raman spectroscopy as a new, easy, fast, and accurate diagnostic method to support diagnostic decisions...
February 23, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29472920/host-lipid-mediators-in-leprosy-the-hypothesized-contributions-to-pathogenesis
#5
REVIEW
Carlos A M Silva, John T Belisle
The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae , the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alterations in the metabolism of ω3 and ω6 polyunsaturated fatty acids (PUFAs), and the diverse set of lipid mediators derived from PUFAs. PUFA-derived lipid mediators provide multiple functions during acute inflammation, and some lipid mediators are able to induce both pro- and anti-inflammatory responses as determined by the cell surface receptors being expressed, as well as the cell type expressing the receptors...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29471696/the-recombinant-fusion-protein-cfp10-esat6-difn-has-protective-effect-against-tuberculosis-in-guinea-pigs
#6
Natalya V Permyakova, Pavel A Belavin, Dariya S Pirozhkova, Elena G Ufimtseva, Sergey M Rozov, Sergey R Mursalimov, Yuriy V Sidorchuk, Elena A Uvarova, Alla A Zagorskaya, Tatiana V Marenkova, Svetlana V Bannikova, Evgeniy A Demidov, Konstantin V Starostin, Marionella A Kravchenko, Diana V Vakhrusheva, Roman B Berdnikov, Natalya I Eremeeva, Sergey N Skornyakov, Sergey E Peltek, Elena V Deineko
Development of effective vaccine candidates against tuberculosis is currently the most important challenge in the prevention of this disease since the BCG vaccine fails to guarantee a lifelong protection, while any other approved vaccine with better efficiency is still absent. The protective effect of the recombinant fusion protein ESAT6-CFP10-dIFN produced in a prokaryotic expression system (Escherichia coli) has been assessed in a guinea pig model of acute tuberculosis. The tested antigen comprises the Mycobacterium tuberculosis (Mtb) proteins ESAT6 and CFP10 as well as modified human γ-interferon (dIFN) for boosting the immune response...
February 23, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29471413/combined-cistrome-and-transcriptome-analysis-of-ski-in-aml-cells-identifies-ski-as-a-co-repressor-for-runx1
#7
Christine Feld, Peeyush Sahu, Miriam Frech, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Uta-Maria Bauer, Andreas Neubauer
SKI is a transcriptional co-regulator and overexpressed in various human tumors, for example in acute myeloid leukemia (AML). SKI contributes to the origin and maintenance of the leukemic phenotype. Here, we use ChIP-seq and RNA-seq analysis to identify the epigenetic alterations induced by SKI overexpression in AML cells. We show that approximately two thirds of differentially expressed genes are up-regulated upon SKI deletion, of which >40% harbor SKI binding sites in their proximity, primarily in enhancer regions...
February 20, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29470355/effects-of-warm-versus-cold-ischemic-donor-lung-preservation-on-the-underlying-mechanisms-of-injuries-during-ischemia-and-reperfusion
#8
Ilker Iskender, Marcelo Cypel, Tereza Martinu, Manyin Chen, Jin Sakamoto, Hyunhee Kim, Keke Yu, Huiqing Lin, Zehong Guan, Kohei Hashimoto, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ischemia-reperfusion injury related to lung transplantation is a major contributor to early postoperative morbidity and mortality. We hypothesized that donation after cardiac death donor lungs experience warm ischemic conditions that activate different injurious mechanisms compared with donor lungs that undergo prolonged cold ischemic conditions. METHODS: Rat donor lungs were preserved under different cold ischemic times (CIT: 12 hours or 18 hours), or under warm ischemia time (WIT: 3 hours) after cardiac death, followed by single left lung transplantation...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470128/human-subcutaneous-tissue-response-to-glucose-sensors-macrophages-accumulation-impact-on-sensor-accuracy
#9
Mercedes Rigla, Belén Pons, Pere Rebasa, Alexis Luna, Francisco Javier Pozo, Assumpta Caixàs, Maria Villaplana, David Subías, Maria Rosa Bella, Neus Combalia
BACKGROUND: Subcutaneous (s.c.) glucose sensors have become a key component in type 1 diabetes management. However, their usability is limited by the impact of foreign body response (FBR) on their duration, reliability, and accuracy. Our study gives the first description of human acute and subacute s.c. response to glucose sensors, showing the changes observed in the sensor surface, the inflammatory cells involved in the FBR and their relationship with sensor performance. METHODS: Twelve obese patients (seven type 2 diabetes) underwent two abdominal biopsies comprising the surrounding area where they had worn two glucose sensors: the first one inserted 7 days before and the second one 24 h before biopsy procedure...
February 22, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29469962/apremilast-alters-behavioral-responses-to-ethanol-in-mice-i-reduced-ethanol-consumption-and-preference
#10
Yuri A Blednov, Adriana J Da Costa, Tamara Tarbox, Olga Ponomareva, Robert O Messing, R Adron Harris
BACKGROUND: Phosphodiesterase type 4 (PDE4) inhibitors produce widespread anti-inflammatory effects and reduce ethanol consumption in several rodent models. These drugs are potential treatments for several diseases, including central nervous system disorders, but clinical use is limited by their emetic activity. Apremilast is a selective PDE4 inhibitor with fewer gastrointestinal side effects that is FDA approved for the treatment of psoriasis. METHODS: We measured the acute and chronic effects of apremilast on ethanol consumption in male and female C57BL/6J mice using the continuous and intermittent 24-h two-bottle choice drinking models...
February 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29469612/the-atypical-chemokine-receptor-ackr2-drives-pulmonary-fibrosis-by-tuning-influx-of-ccr2-and-ccr5-ifn%C3%AE-producing-%C3%AE-%C3%AE-t-cells-in-mice
#11
Remo Castro Russo, Benedetta Savino, Massimiliano Mirolo, Chiara Buracchi, Giovanni Germano, Achille Anselmo, Luca Zammataro, Fabio Pasqualini, Alberto Mantovani, Massimo Locati, Mauro M Teixeira
RATIONALE: Chemokines coordinate lung inflammation and fibrosis by acting on chemokine receptors expressed on leukocytes and other cell types. Atypical chemokine receptors (ACKRs) bind, internalize and degrade chemokines, tuning homeostasis and immune responses. ACKR2 recognizes and decreases levels of inflammatory CC chemokines. The role of ACKR2 in fibrogenesis is unknown. OBJECTIVE: Investigate the role of ACKR2 in the context of pulmonary fibrosis. METHODS: The effects of ACKR2 expression and deficiency during inflammation and fibrosis were analyzed using a bleomycin-model of fibrosis, ACKR2-deficient mice, bone marrow chimeras and antibody-mediated leukocyte depletion...
February 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29468579/mouse-injury-model-of-polytrauma-and-shock
#12
Juan C Mira, Dina C Nacionales, Tyler J Loftus, Ricardo Ungaro, Brittany Mathias, Alicia M Mohr, Lyle L Moldawer, Philip A Efron
Severe injury and shock remain major sources of morbidity and mortality worldwide. Immunologic dysregulation following trauma contributes to these poor outcomes. Few, if any, therapeutic interventions have benefited these patients, and this is due to our limited understanding of the host response to injury and shock. The Food and Drug Administration requires preclinical animal studies prior to any interventional trials in humans; thus, animal models of injury and shock will remain the mainstay for trauma research...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29468002/idiopathic-non-traumatic-facial-nerve-palsy-bell-s-palsy-in-neonates-an-atypical-age-and-management-dilemma
#13
Abdulhafeez M Khair, Khalid Ibrahim
Idiopathic (Bell's) palsy is the commonest cause of unilateral facial paralysis in children. Although being idiopathic by definition, possible infectious, inflammatory, and ischemic triggers have been suggested. Bell's palsy is thought to be responsible for up to three-fourths of cases of acute unilateral facial paralysis worldwide. The diagnosis has to be reached after other causes of acute peripheral palsy have been excluded. However, it is rarely described in neonates and young infants. Steroids may have some role in treatment, but antiviral therapies have doubtful evidence of benefit...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467962/inflammatory-responses-and-inflammation-associated-diseases-in-organs
#14
REVIEW
Linlin Chen, Huidan Deng, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commonly the NF-κB, MAPK, and JAK-STAT pathways...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467007/enhanced-glycolysis-contributes-to-the-pathogenesis-of-experimental-autoimmune-neuritis
#15
Ru-Tao Liu, Min Zhang, Chun-Lin Yang, Peng Zhang, Na Zhang, Tong Du, Meng-Ru Ge, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan
BACKGROUND: With the recognition of the key roles of cellular metabolism in immunity, targeting metabolic pathway becomes a new strategy for autoimmune disease treatment. Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory demyelinating disease of the peripheral nervous system, characterized by inflammatory cell infiltration. These inflammatory cells, including activated macrophages, Th1 cells, and Th17 cells, generally undergo metabolic reprogramming and rely mainly on glycolysis to exert functions...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29467001/neuregulin-1-elicits-a-regulatory-immune-response-following-traumatic-spinal-cord-injury
#16
Arsalan Alizadeh, Kallivalappil T Santhosh, Hardeep Kataria, Abdelilah S Gounni, Soheila Karimi-Abdolrezaee
BACKGROUND: Spinal cord injury (SCI) triggers a robust neuroinflammatory response that governs secondary injury mechanisms with both degenerative and pro-regenerative effects. Identifying new immunomodulatory therapies to promote the supportive aspect of immune response is critically needed for the treatment of SCI. We previously demonstrated that SCI results in acute and permanent depletion of the neuronally derived Neuregulin-1 (Nrg-1) in the spinal cord. Increasing the dysregulated level of Nrg-1 through acute intrathecal Nrg-1 treatment enhanced endogenous cell replacement and promoted white matter preservation and functional recovery in rat SCI...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29466693/acute-extracellular-matrix-inflammatory-and-mapk-response-to-lengthening-contractions-in-elderly-human-skeletal-muscle
#17
Jacob R Sorensen, Caitlin Skousen, Alex Holland, Kyle Williams, Robert D Hyldahl
To uncover potential factors that may be involved in the impaired regenerative capacity of aged skeletal muscle, we comprehensively assessed the molecular stress response following muscle damage in old and young individuals. 10 young (22.7 ± 2.25 yrs) and 8 physically active old (70.9 ± 7.5 yrs) subjects completed a bout of 300 lengthening contractions (LC), and muscle biopsies were taken pre-exercise and at 3, 24, and 72 h post-LC. Both age groups performed the same amount of work during LC, with the old group displaying a resistance to LC-induced fatigue during the exercise...
February 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29466421/protective-effects-and-immunomodulation-on-piglets-infected-with-rotavirus-following-resveratrol-supplementation
#18
Qiankun Cui, Qiuting Fu, Xinghong Zhao, Xu Song, Jiankang Yu, Yi Yang, Kai Sun, Lu Bai, Ye Tian, Shufan Chen, Renyong Jia, Yuanfeng Zou, Lixia Li, Xiaoxia Liang, Changliang He, Lizi Yin, Gang Ye, Cheng Lv, Guizhou Yue, Zhongqiong Yin
Rotavirus (RV), belonging to Reoviridae family, is the leading cause of acute severe viral diarrhea in children (under 5 years old) and infant animals worldwide. Although vaccines are commonly used to prevent infection, episodes of diarrhea caused by RV frequently occur. Thus, this study was conducted to determine whether resveratrol had protective effects against RV infection in piglets. Following pretreatment with resveratrol dry suspension through adding into the basal diet for 3 weeks, the piglets were orally challenged with RV...
2018: PloS One
https://www.readbyqxmd.com/read/29466390/the-role-of-complement-activation-in-rhabdomyolysis-induced-acute-kidney-injury
#19
XuDong Huang, Wei Zhao, LiXia Zhang, XinJun Yang, LiHui Wang, YunShuang Chen, JingHua Wang, Chao Zhang, GuangLi Wu
Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol...
2018: PloS One
https://www.readbyqxmd.com/read/29463546/treatment-with-atorvastatin-provides-additional-benefits-to-imipenem-in-a-model-of-gram-negative-pneumonia-induced-by-klebsiella-pneumoniae-in-mice
#20
Talles Prosperi de Paula, Patrícia Campi Santos, Raquel Duque do Nascimento Arifa, Angélica T Vieira, Ludmila de Matos Baltazar, Thiago Vinícius Ávila, Caio Tavares Fagundes, Zélia Menezes Garcia, Renata Lacerda Lima, Mauro Martins Teixeira, Danielle G Souza
The clinical pathogen Klebsiella pneumoniae is a relevant cause of nosocomial infections and resistance to current treatment with carbapenem antibiotics is becoming a significant problem. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) used for controlling plasma cholesterol levels. There is clinical evidence showing other effects of statins, including decrease of lung inflammation. In the current study, we show that pretreatment with atorvastatin markedly attenuated lung injury, which was correlated with a reduction in the cellular influx into the alveolar space and lungs and down-modulation of the production of pro-inflammatory mediators in the initial phase of infection in C57BL/6 mice with K...
February 20, 2018: Antimicrobial Agents and Chemotherapy
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