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https://www.readbyqxmd.com/read/29775566/the-challenge-of-discordant-serology-in-chagas-disease-the-role-of-two-confirmatory-techniques-in-inconclusive-cases
#1
Zaira Moure, Elena Sulleiro, Laura Iniesta, Carmen Guillen, Israel Molina, M Magdalena Alcover, Cristina Riera, Tomás Pumarola, Roser Fisa
Serodiscordance in Chagas disease (CD) remains a challenge since individuals with inconclusive results are clinically complicated to manage. This work, conducted outside the endemic area, aims to compare two different confirmatory techniques for the diagnosis of CD in individuals without a definitive diagnosis, to analyze the performance of the screening techniques in this group of patients, and to describe the serological follow-up of these subjects over time. Sera from 48 individuals with repeatedly discordant results by one recombinant enzyme immunoassay (r-ELISA) and one native ELISA (n-ELISA), were included in the study...
May 15, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29774974/stiffness-reconstruction-methods-for-mr-elastography
#2
Daniel Fovargue, David Nordsletten, Ralph Sinkus
Assessment of tissue stiffness is desirable for clinicians and researchers, as it is well established that pathophysiological mechanisms often alter the structural properties of tissue. Magnetic resonance elastography (MRE) provides an avenue for measuring tissue stiffness and has a long history of clinical application, including staging liver fibrosis and stratifying breast cancer malignancy. A vital component of MRE consists of the reconstruction algorithms used to derive stiffness from wave-motion images by solving inverse problems...
May 18, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29772485/neurocognitive-dysfunction-in-subjects-at-clinical-high-risk-for-psychosis-a-meta-analysis
#3
Wei Zheng, Qing-E Zhang, Dong-Bin Cai, Chee H Ng, Gabor S Ungvari, Yu-Ping Ning, Yu-Tao Xiang
Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66...
May 5, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29764557/-development-and-application-of-disposable-constant-volume-and-negative-pressure-drainage-device
#4
Dongzhi Liu
The common negative pressure drainage bottle used in the vacuum sealing drainage (VSD) cannot quantitative and automatically cut off. Excessive drainage damages the negative pressure source, causes drainage interruption, so once drainage was continuously performed, medical staff need to closely observe drainage bottle calibration. It was also important to known whether there was a large amount of fresh blood sucked out during continuous drainage because it could lose too much blood. To solve these two problems, we designed a kind of negative pressure drainage device, which volume was constant, with the function of automatic cutting off continuous drainage...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29761953/-epileptic-electroencephalogram-recognition-based-on-discrete-s-transform-and-permutation-entropy
#5
Jianzhao Zhang, Wei Jiang, Hui Yuan, Wei Shang, Shi Liu, Ping Jiao
Electroencephalogram(EEG) analysis has important reference value in the diagnosis of epilepsy. The automatic classification of epileptic EEG can be used to judge the patient's situation in time,which is of great significance in clinical application. In order to solve the problem that the recognition accuracy is not high by using the single feature of EEG signals and avoid the influence of wavelet basis function selection on recognition results,a method of automatic discrimination of epileptic EEG signals based on S transform and permutation entropy is proposed...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29757721/spectrum-of-extratesticular-and-testicular-pathologic-conditions-at-scrotal-mr-imaging
#6
Pardeep K Mittal, Ahmed S Abdalla, Argha Chatterjee, Deborah A Baumgarten, Peter A Harri, Jay Patel, Courtney C Moreno, Helena Gabriel, Frank H Miller
Diagnostic workup of scrotal lesions should begin with a complete clinical history and physical examination, including analysis of risk factors such as family history of testicular cancer, personal history of tumor in the contralateral testis, and cryptorchidism, followed by imaging. Scrotal ultrasonography (US) with a combination of gray-scale and color Doppler techniques has been the first-line imaging modality for evaluation of testicular and extratesticular lesions because of its low cost, wide availability, and high diagnostic accuracy...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29752679/wavelet-promoted-sparsity-for-non-invasive-reconstruction-of-electrical-activity-of-the-heart
#7
Matthijs Cluitmans, Joël Karel, Pietro Bonizzi, Paul Volders, Ronald Westra, Ralf Peeters
We investigated a novel sparsity-based regularization method in the wavelet domain of the inverse problem of electrocardiography that aims at preserving the spatiotemporal characteristics of heart-surface potentials. In three normal, anesthetized dogs, electrodes were implanted around the epicardium and body-surface electrodes were attached to the torso. Potential recordings were obtained simultaneously on the body surface and on the epicardium. A CT scan was used to digitize a homogeneous geometry which consisted of the body-surface electrodes and the epicardial surface...
May 12, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29751218/coping-strategies-of-caregivers-towards-aggressive-behaviors-of-persons-with-severe-mental-illness
#8
Neethu Bhaskaran Madathumkovilakath, Sindhu Kizhakkeppattu, Saleem Thekekunnath, Firoz Kazhungil
Aggression is one of the chief determinants of caregiver burden in severe mental illnesses. Clinical and treatment implications of aggression in mental illness are predominantly studied in perspectives of mental health care professionals. Coping style of caregivers towards aggression of persons with mental illness is understudied. So we studied coping strategies used by caregivers of patients with severe mental illness towards aggressive behaviors of patients and relationship between aggressive behavior and coping strategies...
April 24, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29743226/understanding-implementation-of-complex-interventions-in-primary-care-teams
#9
Thea Luig, Jodie Asselin, Arya M Sharma, Denise L Campbell-Scherer
BACKGROUND: The implementation of interventions to support practice change in primary care settings is complex. Pragmatic strategies, grounded in empiric data, are needed to navigate real-world challenges and unanticipated interactions with context that can impact implementation and outcomes. OBJECTIVE: This article uses the example of the "5As Team" randomized control trial to explore implementation strategies to promote knowledge transfer, capacity building, and practice integration, and their interaction within the context of an interdisciplinary primary care team...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29740741/zero-extra-dose-pet-delayed-imaging-with-data-driven-attenuation-correction-estimation
#10
Lifang Pang, Wentao Zhu, Yun Dong, Yang Lv, Hongcheng Shi
PURPOSE: Delayed positron emission tomography (PET) imaging may improve sensitivity and specificity in lesion detection. We proposed a PET data-driven method to estimate the attenuation map (AM) for the delayed scan without an additional x-ray computed tomography (CT). PROCEDURES: An emission-attenuation-scatter joint estimation framework was developed. Several practical issues for clinical datasets were addressed. Particularly, the unknown scatter correction was incorporated in the joint estimation algorithm...
May 8, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29739538/opioid-related-side-effects-postoperative-ileus-urinary-retention-nausea-and-vomiting-and-shivering-a-review-of-the-literature
#11
REVIEW
Hans Donald de Boer, Olivier Detriche, Patrice Forget
Opioids are widely used in clinical anesthesia. However, side effects include postoperative nausea and vomiting, shivering, ileus, and urine retention and are specifically discussed here. From the available evidence, it appears that the use of opioids is strongly associated with impaired gastrointestinal motility. Therefore, to prevent postoperative ileus, the use of opioids should be minimized and opioids should be replaced by other drugs. With regard to the risk of postoperative urinary retention, one problem is the lack of standardized definition...
December 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29737042/oct-based-angiography-device-with-real-time-angiography-b-scans-visualization-and-hand-held-probe-for-everyday-clinical-use
#12
Alexander Moiseev, Sergey Ksenofontov, Marina Sirotkina, Elena Kiseleva, Maria Gorozhantseva, Natalia Shakhova, Lev Matveev, Vladimir Zaytsev, Alexander Matveev, Elena Zagaynova, Valentin Gelikonov, Natalia Gladkova, Alex Vitkin, Grigory Gelikonov
This work is dedicated to the development of the OCT system with angiography for everyday clinical use. Two major problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (e.g., respiratory and cardiac motions) and on-line visualization of vessel cross-sections to provide feedback for the system operator. Visualization of oral mucosa microvasculature with the proposed technique.
May 7, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29732677/creation-and-implementation-of-a-flipped-jigsaw-activity-to-stimulate-interest-in-biochemistry-among-medical-students
#13
Charlene Williams, Susan Perlis, John Gaughan, Sangita Phadtare
Learner-centered pedagogical methods that are based on clinical application of basic science concepts through active learning and problem solving are shown to be effective for improving knowledge retention. As the clinical relevance of biochemistry is not always apparent to health-profession students, effective teaching of medical biochemistry should highlight the implications of biochemical concepts in pathology, minimize memorization, and make the concepts memorable for long-term retention. Here, we report the creation and successful implementation of a flipped jigsaw activity that was developed to stimulate interest in learning biochemistry among medical students...
May 6, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29731968/blockage-of-the-mevalonate-pathway-overcomes-the-apoptotic-resistance-to-mek-inhibitors-with-suppressing-the-activation-of-akt-in-cancer-cells
#14
Mahiro Iizuka-Ohashi, Motoki Watanabe, Mamiko Sukeno, Mie Morita, Ngoc Thi Hong Hoang, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Yoshihiro Sowa, Koichi Sakaguchi, Tetsuya Taguchi, Toshiyuki Sakai
With increasing clinical demands for MEK inhibitors in cancer treatment, overcoming the resistance to MEK inhibitors is an urgent problem to be solved. Numerous reports have shown that MEK inhibition results in the activation of PI3K-Akt signaling, which may confer apoptotic resistance to MEK inhibitors. We here demonstrate that the blockade of the mevalonate pathway using the antilipidemic drug statins represses Akt activation following MEK inhibition and induces significant apoptosis when co-treated with CH5126766 or trametinib...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730870/effects-of-gender-reassignment-on-quality-of-life-and-mental-health-in-people-with-gender-dysphoria
#15
Berna Özata Yıldızhan, Şahika Yüksel, Mirella Avayu, Handan Noyan, Eren Yıldızhan
OBJECTIVE: Our purpose was to compare the life style, family and social relationships (social adaptation) and the quality of life in people with gender dysphoria with and without history of sex reassignment surgery. METHOD: Twenty  individuals (SR group) who were earlier followed   in Istanbul University Psychiatry Department Psychoneurosis and Psychotherapy Unit with gender dysphoria diagnosis in  order  to  have confirmative reports for the sex reassignment (SR) surgery were interviewed at least one year after the surgery...
2018: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29728251/a-future-proof-architecture-for-telemedicine-using-loose-coupled-modules-and-hl7-fhir
#16
Kirstine Rosenbeck Gøeg, Rune Kongsgaard Rasmussen, Lasse Jensen, Christian Møller Wollesen, Søren Larsen, Louise Bilenberg Pape-Haugaard
BACKGROUND AND OBJECTIVES: Most telemedicine solutions are proprietary and disease specific which cause a heterogeneous and silo-oriented system landscape with limited interoperability. Solving the interoperability problem would require a strong focus on data integration and standardization in telemedicine infrastructures. Our objective was to suggest a future-proof architecture, that consisted of small loose-coupled modules to allow flexible integration with new and existing services, and the use of international standards to allow high re-usability of modules, and interoperability in the health IT landscape...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29728185/surgical-timing-for-bilateral-simultaneous-cochlear-implants-when-is-best
#17
Sebastiano Franchella, Roberto Bovo, Luigia Bandolin, Flavia Gheller, Silvia Montino, Daniele Borsetto, Sara Ghiselli, Alessandro Martini
INTRODUCTION: Hearing loss is considered the most common congenital disease and the prevalence of neonatal deafness can be estimated between 1 and 2 cases per 1000 live births. Infant deafness must be diagnosed as early as possible and an effective therapeutic intervention needs to be carried out in order to avoid the serious consequences of hearing deprivation during the evolutionary period: alterations in the development of central auditory pathways and lack of language acquisition...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29724663/effect-of-problem-solving-therapy-versus-supportive-management-in-older-adults-with-low-back-pain-and-depression-while-on-antidepressant-pharmacotherapy
#18
Jordan F Karp, Xiaotian Gao, Abdus S Wahed, Jennifer Q Morse, Bruce L Rollman, Debra K Weiner, Charles F Reynolds
OBJECTIVE: Testing stepped-care approaches that address both depression and low back pain are needed to optimize outcomes in older adults. METHODS: This university-based late-life depression research center assessed 227 adults aged ≥ 60 years with chronic low back pain and depression. In Phase 1 participants received 6 weeks of low-dose venlafaxine (≤150 mg/day). Nonresponders were randomized to 10 weeks of high-dose venlafaxine (up to 300 mg/day) plus problem-solving therapy (PST) or high-dose venlafaxine with supportive management...
March 30, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29724428/acr-appropriateness-criteria-%C3%A2-first-trimester-vaginal-bleeding
#19
Douglas L Brown, Ann Packard, Katherine E Maturen, Sandeep Prakash Deshmukh, Kika M Dudiak, Tara L Henrichsen, Benjamin J Meyer, Liina Poder, Elizabeth A Sadowski, Thomas D Shipp, Lynn Simpson, Therese M Weber, Carolyn M Zelop, Phyllis Glanc
Vaginal bleeding is not uncommon in the first trimester of pregnancy. The majority of such patients will have a normal intrauterine pregnancy (IUP), a nonviable IUP, or an ectopic pregnancy. Ultrasound (US) is the primary imaging modality in evaluation of these patients. US, along with clinical observations and serum human chorionic gonadotropin levels, can usually distinguish these causes. Although it is important to diagnose ectopic pregnancies and nonviable IUPs, one should also guard against injury to normal pregnancies due to inappropriate treatment with methotrexate or surgical intervention...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724422/acr-appropriateness-criteria-%C3%A2-staging-and-follow-up-of-ovarian-cancer
#20
Stella K Kang, Caroline Reinhold, Mostafa Atri, Carol B Benson, Priyadarshani R Bhosale, Anuja Jhingran, Yulia Lakhman, Katherine E Maturen, Refky Nicola, Pari V Pandharipande, Gloria M Salazar, Thomas D Shipp, Lynn Simpson, William Small, Betsy L Sussman, Jennifer W Uyeda, Darci J Wall, Bradford P Whitcomb, Carolyn M Zelop, Phyllis Glanc
In the management of epithelial ovarian cancers, imaging is used for cancer detection and staging, both before and after initial treatment. The decision of whether to pursue initial cytoreductive surgery for ovarian cancer depends in part on accurate staging. Contrast-enhanced CT of the abdomen and pelvis (and chest where indicated) is the current imaging modality of choice for the initial staging evaluation of ovarian cancer. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT and MRI may be appropriate for problem-solving purposes, particularly when lesions are present on CT but considered indeterminate...
May 2018: Journal of the American College of Radiology: JACR
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