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"Cardiac patch"

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https://www.readbyqxmd.com/read/28194397/a-novel-human-tissue-engineered-3-d-functional-vascularized-cardiac-muscle-construct
#1
Mani T Valarmathi, John W Fuseler, Jeffrey M Davis, Robert L Price
Organ tissue engineering, including cardiovascular tissues, has been an area of intense investigation. The major challenge to these approaches has been the inability to vascularize and perfuse the in vitro engineered tissue constructs. Attempts to provide oxygen and nutrients to the cells contained in the biomaterial constructs have had varying degrees of success. The aim of this current study is to develop a three-dimensional (3-D) model of vascularized cardiac tissue to examine the concurrent temporal and spatial regulation of cardiomyogenesis in the context of postnatal de novo vasculogenesis during stem cell cardiac regeneration...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28186692/targeted-genome-engineering-to-control-vegf-expression-in-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-potential-implications-for-the-treatment-of-myocardial-infarction
#2
Hyun-Min Cho, Pyung-Hwan Kim, Hyun-Kyung Chang, Yi-Ming Shen, Kwaku Bonsra, Byung-Jae Kang, Soo-Young Yum, Joo-Hyun Kim, So-Yeong Lee, Min-Cheol Choi, Hyongbum Henry Kim, Goo Jang, Je-Yoel Cho
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) exhibit potency for the regeneration of infarcted hearts. Vascular endothelial growth factor (VEGF) is capable of inducing angiogenesis and can boost stem cell-based therapeutic effects. However, high levels of VEGF can cause abnormal blood vessel growth and hemangiomas. Thus, a controllable system to induce therapeutic levels of VEGF is required for cell therapy. We generated an inducible VEGF-secreting stem cell (VEGF/hUCB-MSC) that controls the expression of VEGF and tested the therapeutic efficacy in rat myocardial infarction (MI) model to apply functional stem cells to MI...
January 3, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28167795/modular-assembly-of-thick-multifunctional-cardiac-patches
#3
Sharon Fleischer, Assaf Shapira, Ron Feiner, Tal Dvir
In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distinct structures and functions. Albumin electrospun fiber scaffolds were laser-patterned to create microgrooves for engineering aligned cardiac tissues exhibiting anisotropic electrical signal propagation. Microchannels were patterned within the scaffolds and seeded with endothelial cells to form closed lumens...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28131907/3d-late-gadolinium-enhanced-cardiovascular-mr-with-centra-plus-profile-view-ordering-feasibility-of-right-ventricular-myocardial-damage-assessment-using-a-swine-animal-model
#4
Keigo Kawaji, Akiko Tanaka, Mita B Patel, Hui Wang, Francesco Maffessanti, Takeyoshi Ota, Amit R Patel
AIMS: To develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV). METHODS AND RESULTS: A k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed...
January 25, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28068869/a-regenerative-cardiac-patch-formed-by-spray-painting-of-biomaterials-onto-the-heart
#5
Junnan Tang, Adam Vandergriff, Zegen Wang, Michael Taylor Hensley, Jhon Cores, Tyler A Allen, Phuong-Uyen Dinh, Jinying Zhang, Thomas George Caranasos, Ke Cheng
Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction (MI). However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic, therefore prevents the translation of this strategy into the clinic. We sought to device a way to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure...
February 13, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28029762/prevascularization-of-decellularized-porcine-myocardial-slice-for-cardiac-tissue-engineering
#6
Pawan Kc, Mickey Shah, Jun Liao, Ge Zhang
Prevacularization strategies have been implemented in tissue engineering to generate microvasculature networks within a scaffold prior to implantation. Prevascularizing scaffolds will shorten the time of functional vascular perfusion with host upon implantation. In this study, we explored key variables affecting the interaction between decellularized porcine myocardium slices (dPMSs) and reseeded stem cells toward the fabrication of prevascularized cardiac tissue. Our results demonstrated that dPMS supports attachment of human mesenchymal stem cells (hMSCs) and rat adipose derived stem cells (rASCs) with high viability...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27943590/a-collagen-cardiac-patch-incorporating-alginate-microparticles-permits-the-controlled-release-of-hgf-and-igf-1-to-enhance-cardiac-stem-cell-migration-and-proliferation
#7
Hugh S O'Neill, Janice O'Sullivan, Niamh Porteous, Eduardo Ruiz Hernandez, Helena M Kelly, Fergal J O'Brien, Garry P Duffy
Cardiac Stem Cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction (MI). However, the isolation and expansion of CSCs prior to cell transplantation is time-consuming, costly and invasive, and the reliability of cell expansion may also prove to be a major obstacle in the clinical application of CSC based transplantation therapy after a MI. In order to overcome this, we propose the incorporation of growth factor-eluting alginate microparticles (MPs) into collagen-based scaffolds as an implantable biomaterial to promote the recruitment and expansion of CSCs in the myocardium...
December 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27906085/tissue-engineered-cardiac-patch-seeded-with-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-promoted-the-regeneration-of-host-cardiomyocytes-in-a-rat-model
#8
Tadahisa Sugiura, Narutoshi Hibino, Christopher K Breuer, Toshiharu Shinoka
BACKGROUND: Thousands of babies are born with congenital heart defects that require surgical repair involving a prosthetic implant. Lack of growth in prosthetic grafts is especially detrimental in pediatric surgery. Cell seeded biodegradable tissue engineered grafts are a novel solution to this problem. The purpose of the present study is to evaluate the feasibility of seeding human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) onto a biodegradable cardiac patch. METHODS: The hiPS-CMs were cultured on a biodegradable patch composed of a polyglycolic acid (PGA) and a 50:50 poly (l-lactic-co-ε-caprolactone) copolymer (PLCL) for 1 week...
December 1, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27889329/perivascular-cells-and-tissue-engineering-current-applications-and-untapped-potential
#9
REVIEW
Elisa Avolio, Valeria V Alvino, Mohamed T Ghorbel, Paola Campagnolo
The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare...
November 24, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27834123/translational-applications-of-tissue-engineering-in-cardiovascular-medicine
#10
Y Murat Elçin, Arin Dogan, Eser Elçin
Cardiovascular diseases are the leading cause of worldwide deaths. Current paradigm in medicine seeks novel approaches for the treatment of progressive or end-stage diseases. The organ transplantation option is limited in availability and unfortunately, a great number of patients are lost while waiting for donor organs. Animal studies have shown that upon myocardial infarction, it may be possible to stop adverse remodeling in its tracks and reverse with tissue engineering methods. Regaining the myocardium function and avoiding further deterioration towards heart failure can benefit millions of people with a significantly lesser burden on healthcare systems worldwide...
November 11, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27689781/poly-3-hydroxyoctanoate-a-promising-new-material-for-cardiac-tissue-engineering
#11
Andrea V Bagdadi, Maryam Safari, Prachi Dubey, Pooja Basnett, Panagiotis Sofokleous, Eleanor Humphrey, Ian Locke, Mohan Edirisinghe, Cesare Terracciano, Aldo R Boccaccini, Jonathan C Knowles, Sian E Harding, Ipsita Roy
Cardiac tissue engineering (CTE) is currently a prime focus of research due to an enormous clinical need. In this work, a novel functional material, Poly(3-hydroxyoctanoate), P(3HO), a medium chain length polyhydroxyalkanoate (PHA), produced using bacterial fermentation, was studied as a new potential material for CTE. Engineered constructs with improved mechanical properties, crucial for supporting the organ during new tissue regeneration, and enhanced surface topography, to allow efficient cell adhesion and proliferation, were fabricated...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27678265/promoting-cardiomyogenesis-of-hbmsc-with-a-forming-self-assembly-hbmsc-microtissues-ha-grgd-sf-pcl-cardiac-patch-is-mediated-by-the-synergistic-functions-of-ha-grgd
#12
Tze-Wen Chung, Hsin-Yu Lo, Tzung-Han Chou, Jan-Hou Chen, Shoei-Shen Wang
Bone marrow-derived mesenchymal stem cell microtissues (BMSCMT) enhanced cardiomyogenesis in vitro and cardiac repairs of myocardial infarcted hearts in vivo are documented. Producing human BMSCMT onto patches in vitro for cardiac tissue engineering has not been reported. For possibly producing human bone marrow-derived mesenchymal stem cell microtissues (hBMSCMT) on an elastic silk fibroin (SF)-poly(ε-caprolactone) (PCL) based patches is hereby designed. After an elastic SF-PCL (SP) patch is fabricated, hyaluronic acid (HA)/SF-PCL(HSP) and HA-GRGD/SF-PCL(HGSP) patches are fabricated by photochemically grafting HA and HA-GRGD onto SP surfaces...
September 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27624357/the-extracellular-matrix-patch-implanted-in-the-right-ventricle-evaluated-with-cardiovascular-magnetic-resonance-protocol-to-assess-regional-physio-mechanical-properties
#13
Akiko Tanaka, Keigo Kawaji, Amit R Patel, Takeyoshi Ota
OBJECTIVES: An extracellular matrix patch was implanted in the porcine right ventricle for in situ myocardial regeneration. A newly developed cardiovascular magnetic resonance protocol was utilized to investigate the regional physio-mechanical function of the patch. METHODS: Cardiovascular magnetic resonance was performed at 60-day after the porcine right ventricular wall full thickness substitution with an extracellular matrix cardiac patch (n = 5). Dacron patches and remote normal right ventricle served as control (n = 5/each)...
January 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27619839/vegf-loaded-microsphere-patch-for-local-protein-delivery-to-the-ischemic-heart
#14
Jonathan Rodness, Anton Mihic, Yasuo Miyagi, Jun Wu, Richard D Weisel, Ren-Ke Li
BACKGROUND: Revascularization of the heart after myocardial infarction (MI) using growth factors delivered by hydrogel-based microspheres represents a promising therapeutic approach for cardiac regeneration. Microspheres have tuneable degradation properties and support the prolonged release of soluble factors. Cardiac patches provide mechanical restraint, preventing dilatation associated with ventricular remodelling. METHODS: We combined these approaches and produced a compacted calcium-alginate microsphere patch, restrained by a chitosan sheet, to deliver vascular endothelial growth factor (VEGF) to the heart after myocardial injury in rats...
November 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27612749/novel-pgs-pcl-electrospun-fiber-mats-with-patterned-topographical-features-for-cardiac-patch-applications
#15
M Tallawi, D Dippold, R Rai, D D'Atri, J A Roether, D W Schubert, E Rosellini, F B Engel, A R Boccaccini
Nano- and micro-scale topographical features play a critical role in the induction and maintenance of various cellular properties and functions, including morphology, adhesion, gene regulation, and cell-to-cell communication. In addition, recent studies have indicated that the structure and function of heart tissue are also sensitive to mechanical cues at the nano- and micro-scale. Although fabrication methods exist for generating topographical features on polymeric scaffolds for cell culture, current techniques, especially those with nano-scale resolution, are typically complex, prohibitively expensive and not accessible to most biology laboratories...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27579776/bi-layered-polyurethane-extracellular-matrix-cardiac-patch-improves-ischemic-ventricular-wall-remodeling-in-a-rat-model
#16
Antonio D'Amore, Tomo Yoshizumi, Samuel K Luketich, Matthew T Wolf, Xinzhu Gu, Marcello Cammarata, Richard Hoff, Stephen F Badylak, William R Wagner
As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27509303/functional-engineered-human-cardiac-patches-prepared-from-nature-s-platform-improve-heart-function-after-acute-myocardial-infarction
#17
Qingjie Wang, Hui Yang, Aobing Bai, Wei Jiang, Xiuya Li, Xinhong Wang, Yishen Mao, Chao Lu, Ruizhe Qian, Feng Guo, Tianling Ding, Haiyan Chen, Sifeng Chen, Jianyi Zhang, Chen Liu, Ning Sun
With the advent of induced pluripotent stem cells and directed differentiation techniques, it is now feasible to derive individual-specific cardiac cells for human heart tissue engineering. Here we report the generation of functional engineered human cardiac patches using human induced pluripotent stem cells-derived cardiac cells and decellularized natural heart ECM as scaffolds. The engineered human cardiac patches can be tailored to any desired size and shape and exhibited normal contractile and electrical physiology in vitro...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/27262741/vascularization-of-three-dimensional-engineered-tissues-for-regenerative-medicine-applications
#18
REVIEW
Joseph J Kim, Luqia Hou, Ngan F Huang
UNLABELLED: Engineering of three-dimensional (3D) tissues is a promising approach for restoring diseased or dysfunctional myocardium with a functional replacement. However, a major bottleneck in this field is the lack of efficient vascularization strategies, because tissue constructs produced in vitro require a constant flow of oxygen and nutrients to maintain viability and functionality. Compared to angiogenic cell therapy and growth factor treatment, bioengineering approaches such as spatial micropatterning, integration of sacrificial materials, tissue decellularization, and 3D bioprinting enable the generation of more precisely controllable neovessel formation...
September 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27212425/gold-nanorod-incorporated-gelatin-based-conductive-hydrogels-for-engineering-cardiac-tissue-constructs
#19
Ali Navaei, Harpinder Saini, Wayne Christenson, Ryan Tanner Sullivan, Robert Ros, Mehdi Nikkhah
UNLABELLED: The development of advanced biomaterials is a crucial step to enhance the efficacy of tissue engineering strategies for treatment of myocardial infarction. Specific characteristics of biomaterials including electrical conductivity, mechanical robustness and structural integrity need to be further enhanced to promote the functionalities of cardiac cells. In this work, we fabricated UV-crosslinkable gold nanorod (GNR)-incorporated gelatin methacrylate (GelMA) hybrid hydrogels with enhanced material and biological properties for cardiac tissue engineering...
September 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27186292/electrospun-nanofibrous-sheets-of-collagen-elastin-polycaprolactone-improve-cardiac-repair-after-myocardial-infarction
#20
Yang Liu, Yachen Xu, Zhenhua Wang, Dezhong Wen, Wentian Zhang, Sebastian Schmull, Haiyan Li, Yao Chen, Song Xue
Electrospun nanofibrous sheets get increasing attention in myocardial infarction (MI) treatment due to their good cytocompatibility to deliver transplanted stem cells to infarcted areas and due to mechanical characteristics to support damaged tissue. Cardiac extracellular matrix is essential for implanted cells since it provides the cardiac microenvironment. In this study, we hypothesized high concentrations of cardiac nature protein (NP), namely elastin and collagen, in hybrid polycaprolactone (PCL) electrospun nanofibrous sheets could be effective as cardiac-mimicking patch...
2016: American Journal of Translational Research
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