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"Cardiac patch"

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https://www.readbyqxmd.com/read/29875619/auxetic-cardiac-patches-with-tunable-mechanical-and-conductive-properties-toward-treating-myocardial-infarction
#1
Michaella Kapnisi, Catherine Mansfield, Camille Marijon, Anne Geraldine Guex, Filippo Perbellini, Ifigeneia Bardi, Eleanor J Humphrey, Jennifer L Puetzer, Damia Mawad, Demosthenes C Koutsogeorgis, Daniel J Stuckey, Cesare M Terracciano, Sian E Harding, Molly M Stevens
An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Excimer laser microablation is used to micropattern a re-entrant honeycomb (bow-tie) design into a chitosan-polyaniline composite. It is shown that the bow-tie design can produce patches with a wide range in mechanical strength and anisotropy, which can be tuned to match native heart tissue...
May 24, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29807080/fabrication-of-engineered-nanoparticles-on-biological-macromolecular-pegylated-chitosan-composite-for-bio-active-hydrogel-system-in-cardiac-repair-applications
#2
Nanbo Liu, Jimei Chen, Jian Zhuang, Ping Zhu
The development of advanced nano-mediated biological macromolecular (PEGylated Chitosan) hydrogel materials is a vital approach to enhance the efficiency of cardiac tissue applications for treatment of cardiac tissue repair. Definite properties of PEG and chitosan hydrogel matrixes including swelling, mechanical stability and porosity need to be further improved with effective and non-toxic nanoparticles to promote the cell adhesion and organization of cardiac cells. In the current study, we fabricated engineered spherical TiO2 nanoparticles into the biologically active macromolecular (PEG/CTS) hydrogel matrixes with enhanced physico-chemical and biological properties...
May 25, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782947/multifunctional-degradable-electronic-scaffolds-for-cardiac-tissue-engineering
#3
Ron Feiner, Sharon Fleischer, Assaf Shapira, Or Kalish, Tal Dvir
The capability to on-line sense tissue function, provide stimulation to control contractility and efficiently release drugs within an engineered tissue microenvironment may enhance tissue assembly and improve the therapeutic outcome of implanted engineered tissues. To endow cardiac patches with such capabilities we developed elastic, biodegradable, electronic scaffolds. The scaffolds were composed of electrospun albumin fibers that served as both a substrate and a passivation layer for evaporated gold electrodes...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29713290/high-altitude-affects-nocturnal-non-linear-heart-rate-variability-patch-ha-study
#4
Christopher J Boos, Kyo Bye, Luke Sevier, Josh Bakker-Dyos, David R Woods, Mark Sullivan, Tom Quinlan, Adrian Mellor
Background: High altitude (HA) exposure can lead to changes in resting heart rate variability (HRV), which may be linked to acute mountain sickness (AMS) development. Compared with traditional HRV measures, non-linear HRV appears to offer incremental and prognostic data, yet its utility and relationship to AMS have been barely examined at HA. This study sought to examine this relationship at terrestrial HA. Methods: Sixteen healthy British military servicemen were studied at baseline (800 m, first night) and over eight consecutive nights, at a sleeping altitude of up to 3600 m...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29687502/paintable-and-rapidly-bondable-conductive-hydrogels-as-therapeutic-cardiac-patches
#5
Shuang Liang, Yinyu Zhang, Hongbo Wang, Ziyang Xu, Jingrui Chen, Rui Bao, Baoyu Tan, Yuanlu Cui, Guanwei Fan, Wenxin Wang, Wei Wang, Wenguang Liu
In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe3+ -triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage...
June 2018: Advanced Materials
https://www.readbyqxmd.com/read/29651999/photolithographic-stereolithographic-tandem-fabrication-of-4d-smart-scaffolds-for-improved-stem-cell-cardiomyogenic-differentiation
#6
Shida Miao, Haitao Cui, Margaret Nowicki, Se-Jun Lee, José Almeida, Xuan Zhou, Wei Zhu, Xiaoliang Yao, Fahed Masood, Michael W Plesniak, Muhammad Mohiuddin, Lijie Grace Zhang
4D printing is a highly innovative additive manufacturing process for fabricating smart structures with the ability to transform over time. Significantly different from regular 4D printing techniques, this study focuses on creating novel 4D hierarchical micropatterns using a unique photolithographic-stereolithographic-tandem strategy (PSTS) with smart soybean oil epoxidized acrylate (SOEA) inks for effectively regulating human bone marrow mesenchymal stem cell (hMSC) cardiomyogenic behaviors. The 4D effect refers to autonomous conversion of the surficial-patterned scaffold into a predesigned construct through an external stimulus delivered immediately after printing...
May 2, 2018: Biofabrication
https://www.readbyqxmd.com/read/29625872/construction-of-scaffolds-composed-of-acellular-cardiac-extracellular-matrix-for-myocardial-tissue-engineering
#7
Kamyar Esmaeili Pourfarhangi, Shohreh Mashayekhan, Sasan Ghanbari Asl, Zahra Hajebrahimi
High rates of mortality and morbidity stemming from cardiovascular diseases unveil extreme limitations in current therapies despite enormous advances in medical and pharmaceutical sciences. Following myocardial infarction (MI), parts of myocardium undergo irreversible remodeling and is substituted by a scar tissue which eventually leads to heart failure (HF). To address this issue, cardiac patches have been utilized to initiate myocardial regeneration. In this study, a porous cardiac patch is fabricated using a mixture of decellularized myocardium extracellular matrix (ECM) and chitosan (CS)...
May 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29406721/gold-nanorod-based-engineered-cardiac-patch-for-suture-free-engraftment-by-near-ir
#8
Maayan Malki, Sharon Fleischer, Assaf Shapira, Tal Dvir
Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs. Here, nanocomposite scaffolds comprised of albumin electrospun fibers and gold nanorods (AuNRs) were developed. Cardiac cells were seeded within the scaffolds and assembled into a functioning patch. The engineered tissue was then positioned on the myocardium and irradiated with a near IR laser (808 nm)...
February 8, 2018: Nano Letters
https://www.readbyqxmd.com/read/29381054/mesh-nanoelectronics-seamless-integration-of-electronics-with-tissues
#9
Xiaochuan Dai, Guosong Hong, Teng Gao, Charles M Lieber
Nanobioelectronics represents a rapidly developing field with broad-ranging opportunities in fundamental biological sciences, biotechnology, and medicine. Despite this potential, seamless integration of electronics has been difficult due to fundamental mismatches, including size and mechanical properties, between the elements of the electronic and living biological systems. In this Account, we discuss the concept, development, key demonstrations, and future opportunities of mesh nanoelectronics as a general paradigm for seamless integration of electronics within synthetic tissues and live animals...
February 20, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29160940/morphological-transformation-of-hbmsc-from-2d-monolayer-to-3d-microtissue-on-low-crystallinity-sf-pcl-patch-with-promotion-of-cardiomyogenesis
#10
Hsin-Yu Lo, An-Li Huang, Pei-Chi Lee, Tze-Wen Chung, Shoei-Shen Wang
The effects of the stiffness of substrates on the cell behaviours of human bone marrow-derived mesenchymal stem cells (hBMSC) have been investigated, but the effects of the secondary structures of proteins in the substrates on the morphological transformation and differentiation of hBMSC have yet been elucidated. To investigate these issues, silk fibroin-poly(ε-caprolactone) SP cardiac patches of poly(ε-caprolactone; P), on which is grafted by silk fibroin (SF) with various β-sheet contents (or crystallinity) to provide various degrees of stiffness, were produced to examine the in vitro behaviours of hBMSC during proliferation, and cardiomyogenesis on the SP patches...
April 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29078233/comparing-the-host-reaction-to-cormatrix-and-different-cardiac-patch-materials-implanted-subcutaneously-in-growing-pigs
#11
Zahra Mosala Nezhad, Alain Poncelet, Caroline Fervaille, Pierre Gianello
No abstract text is available yet for this article.
October 27, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29050528/uv-assisted-3d-bioprinting-of-nanoreinforced-hybrid-cardiac-patch-for-myocardial-tissue-engineering
#12
Mohammad Izadifar, Dean Chapman, Paul Babyn, Xiongbiao Chen, Michael E Kelly
Biofabrication of cell supportive cardiac patches that can be directly implanted on myocardial infarct is a potential solution for myocardial infarction repair. Ideally, cardiac patches should be able to mimic myocardium extracellular matrix for rapid integration with the host tissue, raising the need to develop cardiac constructs with complex features. In particular, cardiac patches should be electrically conductive, mechanically robust and elastic, biologically active and prevascularized. In this study, we aim to biofabricate a nanoreinforced hybrid cardiac patch laden with human coronary artery endothelial cells (HCAECs) with improved electrical, mechanical, and biological behavior...
February 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28888004/cardiomyocyte-coculture-on-layered-fibrous-scaffolds-assembled-from-micropatterned-electrospun-mats
#13
Yaowen Liu, Guisen Xu, Jiaojun Wei, Qiang Wu, Xiaohong Li
Challenges remain in engineering cardiac tissues with functional and morphological properties similar to those of native myocardium. In the current study, micropatterned fibrous mats are obtained by deposition of electrospun fibers on lithographic collectors to reproduce the anisotropic structure of myocardium, and carbon nanotubes are included in fibers to provide conductivities at the same level of cardiac muscles. The patterned mats are assembled layer-by-layer into patterned scaffolds for coculture of primary cardiomyocytes (CMs) with cardiac fibroblasts (CFs) and endothelial cells (ECs)...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28875946/pva-dextran-hydrogel-patches-as-delivery-system-of-antioxidant-astaxanthin-a-cardiovascular-approach
#14
M Zuluaga, G Gregnanin, C Cencetti, C Di Meo, V Gueguen, D Letourneur, A Meddahi-Pellé, G Pavon-Djavid, P Matricardi
After myocardial infarction, the heart's mechanical properties and its intrinsic capability to recover are compromised. To improve this recovery, several groups have developed cardiac patches based on different biomaterials strategies. Here, we developed polyvinylalcohol/dextran (PVA/Dex) elastic hydrogel patches, obtained through the freeze thawing (FT) process, with the aim to deliver locally a potent natural antioxidant molecule, astaxanthin, and to assist the heart's response against the generated myofibril stress...
December 28, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28875579/a-cardiac-patch-from-aligned-microvessel-and-cardiomyocyte-patches
#15
Jeremy A Schaefer, Pilar A Guzman, Sonja B Riemenschneider, Timothy J Kamp, Robert T Tranquillo
Cardiac tissue engineering aims to produce replacement tissue patches in the lab to replace or treat infarcted myocardium. However, current patches lack preformed microvascularization and are therefore limited in thickness and force production. In this study, we sought to assess whether a bilayer patch composed of a layer made from human induced pluripotent stem cell-derived cardiomyocytes and a microvessel layer composed of self-assembled human blood outgrowth endothelial cells and pericytes was capable of engrafting on the epicardial surface of a nude rat infarct model and becoming perfused by the host 4 weeks after acute implantation...
February 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28857082/basic-research-minimally-invasive-delivery-of-engineered-cardiac-patches-for-heart-repair
#16
Karina Huynh
No abstract text is available yet for this article.
October 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28805824/flexible-shape-memory-scaffold-for-minimally-invasive-delivery-of-functional-tissues
#17
Miles Montgomery, Samad Ahadian, Locke Davenport Huyer, Mauro Lo Rito, Robert A Civitarese, Rachel D Vanderlaan, Jun Wu, Lewis A Reis, Abdul Momen, Saeed Akbari, Aric Pahnke, Ren-Ke Li, Christopher A Caldarone, Milica Radisic
Despite great progress in engineering functional tissues for organ repair, including the heart, an invasive surgical approach is still required for their implantation. Here, we designed an elastic and microfabricated scaffold using a biodegradable polymer (poly(octamethylene maleate (anhydride) citrate)) for functional tissue delivery via injection. The scaffold's shape memory was due to the microfabricated lattice design. Scaffolds and cardiac patches (1 cm × 1 cm) were delivered through an orifice as small as 1 mm, recovering their initial shape following injection without affecting cardiomyocyte viability and function...
October 2017: Nature Materials
https://www.readbyqxmd.com/read/28715377/creation-of-cardiac-tissue-exhibiting-mechanical-integration-of-spheroids-using-3d-bioprinting
#18
Chin Siang Ong, Takuma Fukunishi, Andrew Nashed, Adriana Blazeski, Huaitao Zhang, Samantha Hardy, Deborah DiSilvestre, Luca Vricella, John Conte, Leslie Tung, Gordon Tomaselli, Narutoshi Hibino
This protocol describes 3D bioprinting of cardiac tissue without the use of biomaterials, using only cells. Cardiomyocytes, endothelial cells and fibroblasts are first isolated, counted and mixed at desired cell ratios. They are co-cultured in individual wells in ultra-low attachment 96-well plates. Within 3 days, beating spheroids form. These spheroids are then picked up by a nozzle using vacuum suction and assembled on a needle array using a 3D bioprinter. The spheroids are then allowed to fuse on the needle array...
July 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28676704/biomaterial-free-three-dimensional-bioprinting-of-cardiac-tissue-using-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#19
Chin Siang Ong, Takuma Fukunishi, Huaitao Zhang, Chen Yu Huang, Andrew Nashed, Adriana Blazeski, Deborah DiSilvestre, Luca Vricella, John Conte, Leslie Tung, Gordon F Tomaselli, Narutoshi Hibino
We have developed a novel method to deliver stem cells using 3D bioprinted cardiac patches, free of biomaterials. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to create mixed cell spheroids. Cardiac patches were created from spheroids (CM:FB:EC = 70:15:15, 70:0:30, 45:40:15) using a 3D bioprinter. Cardiac patches were analyzed with light and video microscopy, immunohistochemistry, immunofluorescence, cell viability assays and optical electrical mapping...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28664892/potential-of-propagation-based-synchrotron-x-ray-phase-contrast-computed-tomography-for-cardiac-tissue-engineering
#20
Mohammad Izadifar, Paul Babyn, Dean Chapman, Michael E Kelly, Xiongbiao Chen
Hydrogel-based cardiac tissue engineering offers great promise for myocardial infarction repair. The ability to visualize engineered systems in vivo in animal models is desired to monitor the performance of cardiac constructs. However, due to the low density and weak X-ray attenuation of hydrogels, conventional radiography and micro-computed tomography are unable to visualize the hydrogel cardiac constructs upon their implantation, thus limiting their use in animal systems. This paper presents a study on the optimization of synchrotron X-ray propagation-based phase-contrast imaging computed tomography (PCI-CT) for three-dimensional (3D) visualization and assessment of the hydrogel cardiac patches...
July 1, 2017: Journal of Synchrotron Radiation
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