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https://www.readbyqxmd.com/read/28527216/effects-of-healthy-aging-and-mild-cognitive-impairment-on-a-real-life-decision-making-task
#1
Marie-Theres Pertl, Thomas Benke, Laura Zamarian, Margarete Delazer
In this study, we investigated the effects of age and of mild cognitive impairment (MCI) on decision making under risk by adopting a task representing real-life health-related situations and involving complex numerical information. Moreover, we assessed the relationship of real-life decision making to other cognitive functions such as number processing, executive functions, language, memory, and attention. For this reason, we compared the performance of 19 healthy, relatively younger adults with that of 18 healthy older adults as well as the performance of the 18 healthy older adults with that of 17 patients with MCI...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28526889/the-contribution-of-an-asthma-diagnostic-consultation-service-in-obtaining-an-accurate-asthma-diagnosis-for-primary-care-patients-results-of-a-real-life-study
#2
R M E Gillis, W van Litsenburg, R H van Balkom, J W Muris, F W Smeenk
Previous studies showed that general practitioners have problems in diagnosing asthma accurately, resulting in both under and overdiagnosis. To support general practitioners in their diagnostic process, an asthma diagnostic consultation service was set up. We evaluated the performance of this asthma diagnostic consultation service by analysing the (dis)concordance between the general practitioners working hypotheses and the asthma diagnostic consultation service diagnoses and possible consequences this had on the patients' pharmacotherapy...
May 19, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28526822/shortest-paths-in-multiplex-networks
#3
Saeed Ghariblou, Mostafa Salehi, Matteo Magnani, Mahdi Jalili
The shortest path problem is one of the most fundamental networks optimization problems. Nowadays, individuals interact in extraordinarily numerous ways through their offline and online life (e.g., co-authorship, co-workership, or retweet relation in Twitter). These interactions have two key features. First, they have a heterogeneous nature, and second, they have different strengths that are weighted based on their degree of intimacy, trustworthiness, service exchange or influence among individuals. These networks are known as multiplex networks...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526563/live-cell-imaging-and-analysis-of-lipid-droplets-biogenesis-in-hcv-infected-cells
#4
Inbar Nevo-Yassaf, Marcos Lovelle, Yaacov Nahmias, Koret Hirschberg, Ella H Sklan
Lipid droplets (LDs) are regulated neutral lipid storage organelles having a central role in numerous cellular processes as well as in various pathologies such as metabolic disorders, immune responses and during pathogen infection. Several viruses were found to use the interface between the endoplasmic reticulum (ER) and LDs as the site for replication and assembly. Due to the growing significance of LDs, extensive efforts are made to study the mechanism and the dynamics of their formation and life history and how are these diverted or modified by pathogens...
May 16, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28526053/pre-hospital-triage-performance-after-standardized-trauma-courses
#5
Maria Lampi, Johan Junker, Peter Berggren, Carl-Oscar Jonson, Tore Vikström
BACKGROUND: The pre-hospital triage process aims at identifying and prioritizing patients in the need of prompt intervention and/or evacuation. The objective of the present study was to evaluate triage decision skills in a Mass Casualty Incident drill. The study compares two groups of participants in Advanced Trauma Life Support and Pre-Hospital Trauma Life Support courses. METHODS: A questionnaire was used to deal with three components of triage of victims in a Mass Casualty Incident: decision-making; prioritization of 15 hypothetical casualties involved in a bus crash; and prioritization for evacuation...
May 19, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28523462/statin-prescription-strategies-and-atherogenic-cholesterol-goals-attainment-in-lebanese-coronary-artery-disease-patients
#6
Soubra Lama, Domiati Souraya, Fattouh Youssef
Background Current guidelines recommend a low-density lipoprotein cholesterol goal of <1.8 mmol/L (<70 mg/dL) and a non high-density lipoprotein cholesterol (non-HDL-C) goal of <2.6 mmol/L (<00 mg/dL) for coronary artery disease (CAD) patients. Objective This study aimed to describe real-life statin prescription strategies and to assess their effectiveness in terms of LDL-C and non-HDL-C goals attainment in a cohort of CAD patients. Setting Outpatient cardiology specialty clinics located in main Lebanese cities...
May 18, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28522985/dynamic-and-functional-approach-to-human-memory-in-the-brain-a-clinical-neuropsychological-perspective
#7
Yannick Gounden, Mathieu Hainselin, Fabien Cerrotti, Véronique Quaglino
The way how cognition is conceived and represented in brain functioning will directly impact clinical investigations of people with cognitive difficulties. This is particularly evident in the field of clinical neuropsychology where methodologies and tools are justified on a fundamental level by the theoretical foundations adopted. The present article outlined how the dominant influences of structural and anatomo-clinical theories of memory have led to a particular conception of clinical investigations. We propose to reconsider these dominant methods in favor of a more dynamic and functional representation of memory that would be clinically more appropriate...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28522856/diagnosing-congenital-malaria-in-a-high-transmission-setting-clinical-relevance-and-usefulness-of-p-falciparum-hrp2-based-testing
#8
Hamtandi Magloire Natama, Delwendé Florence Ouedraogo, Hermann Sorgho, Eduard Rovira-Vallbona, Elisa Serra-Casas, M Athanase Somé, Maminata Coulibaly-Traoré, Petra F Mens, Luc Kestens, Halidou Tinto, Anna Rosanas-Urgell
Congenital malaria diagnosis is challenging due to frequently observed low parasite density infections, while their clinical relevance during early infancy is not well characterized. In Nanoro health district (Burkina Faso), we determined the prevalence of congenital malaria by real-time quantitative PCR and we assessed the performance of rapid diagnosis test (RDT) and light microscopy (LM) to detect Plasmodium falciparum infections in cord-blood samples. In addition, we examined the usefulness of P. falciparum Histidine Rich Protein2 (PfHRP2) as surrogate biomarker of infection and explored association between congenital malaria and clinical outcomes...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522848/method-to-estimate-relative-risk-using-exposed-proportion-and-case-group-data
#9
Yoichi Yada
A change in risk of an event occurring, which is affected with a factor, is a common issue in many research fields, and relative risk is widely used because of intuitive interpretation. Estimating relative risk has required data from two follow-up groups and can thus be cost and time consuming. Subjects for whom an event occurred (case group) are often observed but generally analyzed in comparison to those for whom an event did not (control group); however, estimating relative risk using case group data without approximation is hindered...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522645/real-life-gh-dosing-patterns-in-children-with-ghd-ts-or-born-sga-a-report-from-the-nordinet%C3%A2-international-outcome-study
#10
Oliver Blankenstein, Marta Snajderova, Joanne C Blair, Effie Pournara, Birgitte Tønnes Pedersen, Isabelle Oliver Petit
OBJECTIVE: To describe real-life dosing patterns in children with growth hormone deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) receiving growth hormone (GH) and enrolled in the NordiNet® International Outcome Study (IOS; NCT00960128) between 2006 and 2016. DESIGN: This non-interventional, multicentre study included paediatric patients diagnosed with GHD (isolated [IGHD] or multiple pituitary hormone deficiency [MPHD]), born SGA or with TS and treated according to everyday clinical practice from the Czech Republic (IGHD/MPHD/SGA/TS: n=425/61/316/119), France (n=1404/188/970/206), Germany (n=2603/351/1387/411) and the UK (n=259/60/87/35)...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28520781/physical-activity-and-sedentary-behaviour-in-daily-life-a-comparative-analysis-of-the-global-physical-activity-questionnaire-gpaq-and-the-sensewear-armband
#11
Michelle Laeremans, Evi Dons, Ione Avila-Palencia, Glòria Carrasco-Turigas, Juan Pablo Orjuela, Esther Anaya, Christian Brand, Tom Cole-Hunter, Audrey de Nazelle, Thomas Götschi, Sonja Kahlmeier, Mark Nieuwenhuijsen, Arnout Standaert, Patrick De Boever, Luc Int Panis
Reduction of sedentary time and an increase in physical activity offer potential to improve public health. However, quantifying physical activity behaviour under real world conditions is a major challenge and no standard of good practice is available. Our aim was to compare the results of physical activity and sedentary behaviour obtained with a self-reported instrument (Global Physical Activity Questionnaire (GPAQ)) and a wearable sensor (SenseWear) in a repeated measures study design. Healthy adults (41 in Antwerp, 41 in Barcelona and 40 in London) wore the SenseWear armband for seven consecutive days and completed the GPAQ on the final day...
2017: PloS One
https://www.readbyqxmd.com/read/28520749/access-and-response-to-direct-antiviral-agents-daa-in-hiv-hcv-co-infected-patients-in-italy-data-from-the-icona-cohort
#12
Antonella d'Arminio Monforte, Alessandro Cozzi-Lepri, Francesca Ceccherini-Silberstein, Andrea De Luca, Sergio Lo Caputo, Antonella Castagna, Cristina Mussini, Antonella Cingolani, Alessandro Tavelli, Milensu Shanyinde, Andrea Gori, Enrico Girardi, Massimo Andreoni, Andrea Antinori, Massimo Puoti
BACKGROUND: Real-life data on access and response to direct antiviral agents (DAA) in HIV-HCV coinfected individuals are lacking. METHODS: HCV viremic, HIV-positive patients from Icona and Hepaicona cohorts naïve to DAA by January 2013 were included. Access and predictors of starting DAA were evaluated. Switches of antiretroviral drugs at starting DAA were described. We calculated sustained virological response (SVR12) in those reaching 12 weeks after end-of-treatment (EOT), and defined treatment failure (TF) as discontinuation of DAA before EOT or non-SVR12...
2017: PloS One
https://www.readbyqxmd.com/read/28517027/lung-function-parameters-in-omalizumab-responder-patients-an-interesting-tool
#13
F Paganin, G Mangiapan, A Proust, A Prudhomme, J Attia, S Marchand-Adam, F Pellet, F Milhe, B Melloni, A Bernady, C Raspaud, C Nocent, P Berger, L Guilleminault
BACKGROUND: Omalizumab, an anti-IgE antibody, is used to treat patients with severe allergic asthma. The evolution of lung function parameters over time and the difference between omalizumab responder and non-responder patients remain inconclusive. The objective of this real-life study was to compare the changes in FEV1 of omalizumab responders and non-responders at 6 months. METHODS: A multicenter analysis was performed in 10 secondary and tertiary institutions...
May 18, 2017: Allergy
https://www.readbyqxmd.com/read/28516890/tocilizumab-in-the-treatment-of-patients-with-rheumatoid-arthritis-in-real-clinical-practice-results-of-an-italian-observational-study
#14
Roberto Caporali, Luca Idolazzi, Stefano Bombardieri, Gianfranco Ferraccioli, Roberto Gerli, Marco Govoni, Marco Matucci Cerinic, Giovanni Pomponio, Fausto Salaffi, Rossella Tirri, Francesca Benaglio, Laura Bianchino, Piercarlo Sarzi-Puttini
OBJECTIVES: To describe the effectiveness and safety of tocilizumab (TCZ), an interleukin-6 receptor inhibitor, in a cohort of patients with rheumatoid arthritis (RA) recruited in clinical practice. METHODS: TRUST was an observational study in RA patients who started treatment with TCZ in the 6 months prior to site activation and were still on treatment at start of study; patients were followed up to 12 months after the first TCZ infusion. RESULTS: 322 RA patients were enrolled in 59 Italian centres (mean age: 55...
May 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516834/comparison-of-antemortem-and-environmental-samples-for-zebrafish-health-monitoring-and-quarantine
#15
Marcus J Crim, Christian Lawrence, Robert S Livingston, Andrei Rakitin, Shane J Hurley, Lela K Riley
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Varioustypes of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routinezebrafish health monitoring. Similarly, antemortem sampling would be advantageous for expediting zebrafish quarantine,without euthanasia of valuable fish. We evaluated the detection of Mycobacterium chelonae, M. fortuitum, M. peregrinum,Pseudocapillaria tomentosa, and Pseudoloma neurophilia in zebrafish, detritus, pooled feces, and filter membranes after filtration of 1000-, 500-, and 150-mL water samples by real-time PCR analysis...
May 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28516480/development-and-feasibility-of-smartphone-application-for-cognitive-behavioural-case-management-of-individuals-with-early-psychosis
#16
Sung-Wan Kim, Ga-Young Lee, Hye-Young Yu, Eun-I Jung, Ju-Yeon Lee, Seon-Young Kim, Jae-Min Kim, Il-Seon Shin, Jin-Sang Yoon
BACKGROUND: This article describes the development of the smartphone application for cognitive-behavioural case management of young individuals with early psychosis and examines the acceptance and potential clinical benefits of this application through a pilot survey. METHODS: Gwangju Bukgu-Community Mental Health Center developed and launched a smartphone application (Heal Your Mind [HYM]) for cognitive-behavioural case management and symptom monitoring. The HYM application for clients includes 6 main modules including thought record, symptom record, daily life record, official notices, communication and scales...
May 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28516067/cognitomics-a-new-approach-for-the-evaluation-of-the-relationship-between-diseases-and-cognition-to-be-designed-based-on-normal-behavioral-tendencies-in-real-life-a-conceptual-framework
#17
EDITORIAL
Ata Pourabbasi, Bagher Larijani
The relationship between medical diseases and cognition has been a point of interest in the last decades. In recent years studies in this field have developed significantly applying various tools such as cognitive tests using psychometric assessments and brain imaging techniques. The main focus of cognitive function in this studies is the process through which this cognition is obtained. It seems a novel methodology is needed while assessing the impact of diseases such as diabetes on cognition based on heavenly religious teachings in which cognition is believed to be the main source of human bliss and not just some measurable quantitative components...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28515895/disruptive-natural-selection-predicts-divergence-between-the-sexes-during-adaptive-radiation
#18
Stephen P De Lisle, Locke Rowe
Evolution of sexual dimorphism in ecologically relevant traits, for example, via resource competition between the sexes, is traditionally envisioned to stall the progress of adaptive radiation. An alternative view is that evolution of ecological sexual dimorphism could in fact play an important positive role by facilitating sex-specific adaptation. How competition-driven disruptive selection, ecological sexual dimorphism, and speciation interact during real adaptive radiations is thus a critical and open empirical question...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28514964/help-problems-in-executing-a-pragmatic-randomized-stepped-wedge-trial-on-the-hospital-elder-life-program-to-prevent-delirium-in-older-patients
#19
Noor Heim, Henk F van Stel, Roelof G Ettema, Roos C van der Mast, Sharon K Inouye, Marieke J Schuurmans
BACKGROUND: A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on the experiences and lessons learned from the conduct of a cluster randomized, stepped wedge trial evaluating the effect of the Hospital Elder Life Program (HELP) in a Dutch hospital setting to prevent older patients from developing delirium. METHODS: We evaluated our trial which was conducted in eight departments in two hospitals in hospitalized patients aged 70 years or older who were at risk for delirium by reflecting on the assumptions that we had and on what we intended to accomplish when we started, as compared to what we actually realized in the different phases of our study...
May 17, 2017: Trials
https://www.readbyqxmd.com/read/28514873/unpacking-community-mobility-a-preliminary-study-into-the-embodied-experiences-of-stroke-survivors
#20
Christa S Nanninga, Louise Meijering, Klaas Postema, Marleen C Schönherr, Ant T Lettinga
PURPOSE: To enrich the discussion on mobility in stroke rehabilitation by translating theoretical repertoires of mobility from the context of geography to rehabilitation. METHOD: Qualitative research methodology was applied, and included in-depth interviews with stroke survivors. RESULTS: This study revealed: (a) social and material differences in clinical, private and public places; (b) ambivalences and shifting tensions in bodily, family and community life; (c) differences in access to resources to be used for mobility...
May 17, 2017: Disability and Rehabilitation
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