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https://www.readbyqxmd.com/read/29783145/electrochemical-biosensor-system-using-a-cmos-microelectrode-array-provides-high-spatially-and-temporally-resolved-images
#1
William Tedjo, Jasmine E Nejad, Rachel Feeny, Lang Yang, Charles S Henry, Stuart Tobet, Tom Chen
The ability to view biological events in real time has contributed significantly to research in the life sciences. While video capture of real time changes in anatomical relationships is important, it is equally important to visualize real time changes in the chemical communications that drive cell behaviors. This paper describes an electrochemical imaging system capable of capturing changes in chemical gradients in live tissue slices. The system consists of a CMOS microchip with 8192 configurable Pt surface electrodes, on-chip potentiostat, on-chip control logic, and a microfluidic device designed to interface with the CMOS chip to support ex vivo tissue experimentation...
April 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29782287/-a-retrospective-analysis-of-the-quality-of-treatment-preceding-acute-coronary-syndrome-in-real-outpatient-practice-in-patients-with-atrial-fibrillation-local-register-data
#2
E I Tarlovskaya, J A Dorofeeva, S V Malcikova
AIM: To study retrospectively the treatment preceding acute coronary syndrome (ACS) in patients with atrial fibrillation (AF) in real-life outpatient practice on the territory of Kirov Region. MATERIALS AND METHODS: The registry included 163 patients with AF who were undergoing rehabilitation following ACS (ACS occurred.
2018: Kardiologiia
https://www.readbyqxmd.com/read/29781982/the-motor-in-implicit-motor-sequence-learning-a-foot-stepping-serial-reaction-time-task
#3
Yue Du, Jane E Clark
This protocol describes a modified serial reaction time (SRT) task used to study implicit motor sequence learning. Unlike the classic SRT task that involves finger-pressing movements while sitting, the modified SRT task requires participants to step with both feet while maintaining a standing posture. This stepping task necessitates whole body actions that impose postural challenges. The foot-stepping task complements the classic SRT task in several ways. The foot-stepping SRT task is a better proxy for the daily activities that require ongoing postural control, and thus may help us better understand sequence learning in real-life situations...
May 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781403/life-cycle-cost-as-basis-to-optimize-waste-collection-in-space-and-time-a-methodology-for-obtaining-a-detailed-cost-breakdown-structure
#4
Vitor Sousa, Celia Dias-Ferreira, João M Vaz, Inês Meireles
Extensive research has been carried out on waste collection costs mainly to differentiate costs of distinct waste streams and spatial optimization of waste collection services (e.g. routes, number, and location of waste facilities). However, waste collection managers also face the challenge of optimizing assets in time, for instance deciding when to replace and how to maintain, or which technological solution to adopt. These issues require a more detailed knowledge about the waste collection services' cost breakdown structure...
May 1, 2018: Waste Management & Research
https://www.readbyqxmd.com/read/29781395/judicialization-2-0-understanding-right-to-health-litigation-in-real-time
#5
João Biehl, Mariana P Socal, Varun Gauri, Debora Diniz, Marcelo Medeiros, Gabriela Rondon, Joseph J Amon
Over the past two decades, debate over the whys, the hows, and the effects of the ever-expanding phenomenon of right-to-health litigation ('judicialization') throughout Latin America have been marked by polarised arguments and limited information. In contrast to claims of judicialization as a positive or negative trend, less attention has been paid to ways to better understand the phenomenon in real time. In this article, we propose a new approach-Judicialization 2.0-that recognises judicialization as an integral part of democratic life...
May 21, 2018: Global Public Health
https://www.readbyqxmd.com/read/29780978/i-ll-be-back-on-the-multiple-lives-of-users-of-a-mobile-activity-tracking-application
#6
Zhiyuan Lin, Tim Althoff, Jure Leskovec
Mobile health applications that track activities, such as exercise, sleep, and diet, are becoming widely used. While these activity tracking applications have the potential to improve our health, user engagement and retention are critical factors for their success. However, long-term user engagement patterns in real-world activity tracking applications are not yet well understood. Here we study user engagement patterns within a mobile physical activity tracking application consisting of 115 million logged activities taken by over a million users over 31 months...
April 2018: Proceedings of the International World-Wide Web Conference
https://www.readbyqxmd.com/read/29780584/opening-the-black-box-of-spring-water-microbiology-from-alpine-karst-aquifers-to-support-proactive-drinking-water-resource-management
#7
REVIEW
Domenico Savio, Philipp Stadler, Georg H Reischer, Alexander K T Kirschner, Katalin Demeter, Rita Linke, Alfred P Blaschke, Regina Sommer, Ulrich Szewzyk, Inés C Wilhartitz, Robert L Mach, Hermann Stadler, Andreas H Farnleitner
Over the past 15 years, pioneering interdisciplinary research has been performed on the microbiology of hydrogeologically well-defined alpine karst springs located in the Northern Calcareous Alps (NCA) of Austria. This article gives an overview on these activities and links them to other relevant research. Results from the NCA springs and comparable sites revealed that spring water harbors abundant natural microbial communities even in aquifers with high water residence times and the absence of immediate surface influence...
May 2018: WIREs. Water
https://www.readbyqxmd.com/read/29780111/life-threatening-hyperkalemia-associated-with-axitinib-treatment-in-patients-with-recurrent-renal-carcinoma-a-case-report
#8
Shigeo Godo, Yoshitaro Yoshida, Naoki Kawamorita, Koji Mitsuzuka, Yu Kawazoe, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto
Axitinib has emerged as a promising antineoplastic agent for the treatment of advanced renal cell carcinoma. Although the administration of axitinib was well-tolerated in clinical trials, the real-world safety and tolerability remain unverified. We herein report a patient with metastatic renal cell carcinoma who suddenly developed life-threatening hyperkalemia following the initiation of axitinib treatment. Although hyperkalemia has been reported with an incidence of <10%, acute severe hyperkalemia may be a considerably critical adverse event of axitinib therapy, especially in patients with risk factors for hyperkalemia...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780096/-the-status-of-glycemic-control-and-hypoglycemia-in-elderly-patients-visiting-the-outpatient-department-specializing-in-diabetes
#9
Yui Soma, Rie Oka, Sumie Fujii, Naoko Ito, Mitsuhiro Kometani, Shigehiro Karashima, Yoshiyu Takeda, Takashi Yoneda, Akimichi Asano
AIM: The Japan Diabetes Society (JDS)/Japan Geriatrics Society (JGS) Joint Committee reported 'Glycemic Targets for Elderly Patients with Diabetes' in 2016. Based on this recommendation, we aimed to clarify 1) the achievement status of glycemic targets in the elderly and 2) the presence of hypoglycemia in real life among elderly individuals with an HbA1c below the lower limit. SUBJECTS AND METHODS: [Analysis I] In 326 elderly with diabetes ≥65 years of age visiting the outpatient department specializing in diabetes, the proportions of patients with HbA1c values below the lower limit and the use of drugs potentially associated with severe hypoglycemia (e...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29779606/students-experiences-with-a-longitudinal-skills-training-program-on-breaking-bad-news-a-follow-up-study
#10
M H Brouwers, H Bor, R Laan, C van Weel, E van Weel-Baumgarten
OBJECTIVE: Breaking bad news (BBN) should be trained, preferably early and following a helical model with multiple sessions over time, including feedback on performance. It's unclear how medical students evaluate such an approach. METHODS: We gathered student opinions regarding a helical BBN training programme, the feedback and emotional support they received, and the applicability of the skills training immediately after BBN skills training (Q1) and after finishing their clinical clerkships (Q2)...
May 7, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29778650/obesity-surgery-makes-patients-healthier-and-more-functional-real-world-results-from-the-united-kingdom-national-bariatric-surgery-registry
#11
Alexander Dimitri Miras, Kamocka Anna, Patel Darshan, Dexter Simon, Finlay Ian, Hopkins C James, Khan Omar, Reddy Marcus, Sedman Peter, Small Peter, Somers Shaw, Suzie Cro, Walton Peter, le Roux Carel W, Welbourn Richard
BACKGROUND: The National Bariatric Surgery Registry (NBSR) is the largest bespoke database in the field in the United Kingdom. OBJECTIVES: Our aim was to analyze the NBSR to determine whether the effects of obesity surgery on associated co-morbidities observed in small, randomized controlled clinical trials could be replicated in a "real life" setting within U.K. healthcare. SETTING: United Kingdom. METHODS: All NBSR entries for operations between 2000 and 2015 with associated demographic and co-morbidity data were analyzed retrospectively...
February 15, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29778642/benefits-of-a-multicomponent-falls-unit-based-exercise-program-in-older-adults-with-falls-in-real-life
#12
Rafael García Molina, Marta Carolina Ruíz Grao, Alicia Noguerón García, Marta Martínez Reig, Mariano Esbrí Víctor, Míkel Izquierdo Redín, Pedro Abizanda Soler
BACKGROUND/OBJECTIVES: Multicomponent exercise programs are the cornerstone in preventing gait and balance impairments and falls in older adults. However, the effects of these programs in usual clinical practice have been poorly analyzed. DESIGN: 4-Month, twice-a-week multicomponent exercise program cohort study in real-life. SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete, Spain. PARTICIPANTS: Sixty-seven participants who had experienced a fall in the previous year were included...
May 17, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29778082/a-review-of-the-impacts-of-tobacco-heating-system-on-indoor-air-quality-versus-conventional-pollution-sources
#13
REVIEW
Violeta Kaunelienė, Marija Meišutovič-Akhtarieva, Dainius Martuzevičius
With the introduction of novel and potentially less polluting nicotine containing products to the market, the impacts of their usage to indoor air quality as opposed to conventional pollution sources must be reviewed and considered. This review study aimed to comparatively analyse changes in indoor air quality as the consequence of tobacco heating system (THS) generated pollution against general indoor air quality in various micro-environments, especially with combustion-based pollution sources present. Indoor concentrations of formaldehyde, acetaldehyde, benzene, toluene, nicotine and PM2...
May 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777865/a-prospective-non-interventional-registry-study-of-patients-initiating-a-course-of-drug-therapy-for-overactive-bladder-perspective-rationale-design-and-methodology
#14
Eric S Rovner, Kevin V Carlson, Anna S Deal, Kavita V Nair, Eva E Oakkar, Julie Park, Eric Gemmen, Rita M Kristy, Katherine L Gooch, Carol R Schermer
INTRODUCTION: Pharmacotherapy of overactive bladder (OAB) typically involves treatment with an antimuscarinic or mirabegron, a β3-adrenoceptor agonist, but real-world evidence on their use, including treatment access, persistence, and switching, is limited. Here, we describe the design of a prospective, multicenter, non-interventional registry of patients beginning a new course of OAB pharmacological therapy in routine clinical practice. METHODS: Adults with an OAB diagnosis for at least 3 months who either initiated a new course of mirabegron or antimuscarinic, or who switched therapy were enrolled into PERSPECTIVE (A Prospective, Non-intErventional Registry Study of Patients Initiating a Course of Drug Therapy for OveractIVE Bladder)...
May 16, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29777605/ethics-and-or-aesthetics-reflections-on-cosmetic-surgery-for-adolescents
#15
Gianluca Montanari Vergallo, Enrico Marinelli, Simona Napoletano, Natale Mario Di Luca, Simona Zaami
Cosmetic surgery entails various ethical issues, even more so in cases involving adolescent patients. Cosmetic surgeons need to take into account how modern societies consider physical appearance an essential component of everyday life, as well as the vulnerability of youths and adolescents. For that reason, it is imperative to thoroughly assess the psychological and emotional states, in addition to the motivations, of minor patients. That goal can be achieved through the use of the DAS-59, (the Derriford Appearance Scale)1 , an effective and dependable tool devised to evaluate the psychological difficulties and distress experienced by people living with problems of appearance...
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29777373/safety-and-feasibility-of-pulmonary-artery-pressure-guided-heart-failure-therapy-rationale-and-design-of-the-prospective-cardiomems-monitoring-study-for-heart-failure-mems-hf
#16
Christiane E Angermann, Birgit Assmus, Stefan D Anker, Johannes Brachmann, Georg Ertl, Friedrich Köhler, Stephan Rosenkranz, Carsten Tschöpe, Philip B Adamson, Michael Böhm
BACKGROUND: Wireless monitoring of pulmonary artery (PA) pressures with the CardioMEMS HF™ system is indicated in patients with New York Heart Association (NYHA) class III heart failure (HF). Randomized and observational trials have shown a reduction in HF-related hospitalizations and improved quality of life in patients using this device in the United States. OBJECTIVE: MEMS-HF is a prospective, non-randomized, open-label, multicenter study to characterize safety and feasibility of using remote PA pressure monitoring in a real-world setting in Germany, The Netherlands and Ireland...
May 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29776524/analysis-of-hourly-crash-likelihood-using-unbalanced-panel-data-mixed-logit-model-and-real-time-driving-environmental-big-data
#17
Feng Chen, Suren Chen, Xiaoxiang Ma
INTRODUCTION: Driving environment, including road surface conditions and traffic states, often changes over time and influences crash probability considerably. It becomes stretched for traditional crash frequency models developed in large temporal scales to capture the time-varying characteristics of these factors, which may cause substantial loss of critical driving environmental information on crash prediction. METHOD: Crash prediction models with refined temporal data (hourly records) are developed to characterize the time-varying nature of these contributing factors...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29776163/constructing-hopf-bifurcation-lines-for-the-stability-of-nonlinear-systems-with-two-time-delays
#18
Romain Modeste Nguimdo
Although the plethora real-life systems modeled by nonlinear systems with two independent time delays, the algebraic expressions for determining the stability of their fixed points remain the Achilles' heel. Typically, the approach for studying the stability of delay systems consists in finding the bifurcation lines separating the stable and unstable parameter regions. This work deals with the parametric construction of algebraic expressions and their use for the determination of the stability boundaries of fixed points in nonlinear systems with two independent time delays...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29776016/psoriasis-area-and-severity-index-pasi-response-in-moderate-severe-psoriatic-patients-switched-to-adalimumab-results-from-the-oppsa-study
#19
M Talamonti, M Galluzzo, N Bernardini, G Caldarola, S Persechino, F Cantoresi, C G Egan, C Potenza, K Peris, L Bianchi
BACKGROUND: Few studies have compared the efficacy of switching to adalimumab in the real-life setting in plaque psoriasis patients. OBJECTIVE: To evaluate the effect of adalimumab in psoriasis patients previously treated with other biologics. METHODS: In this multicentre study, psoriasis patients (N=262) treated with an anti-TNF alpha agent, ustekinumab or naïve to biologics then switched to adalimumab were included. Disease severity was assessed by the Psoriasis Area and Severity Index (PASI) at baseline and after 3, 6, 12, 24 and 36 months...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29775583/correlating-transcription-initiation-and-conformational-changes-by-a-single-subunit-rna-polymerase-with-near-base-pair-resolution
#20
Hye Ran Koh, Rahul Roy, Maria Sorokina, Guo-Qing Tang, Divya Nandakumar, Smita S Patel, Taekjip Ha
We provide a comprehensive analysis of transcription in real time by T7 RNA Polymerase (RNAP) using single-molecule fluorescence resonance energy transfer by monitoring the entire life history of transcription initiation, including stepwise RNA synthesis with near base-pair resolution, abortive cycling, and transition into elongation. Kinetically branching pathways were observed for abortive initiation with an RNAP either recycling on the same promoter or exchanging with another RNAP from solution. We detected fast and slow populations of RNAP in their transition into elongation, consistent with the efficient and delayed promoter release, respectively, observed in ensemble studies...
May 17, 2018: Molecular Cell
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