Natalia Rodon Font, Yessica No Garbarino, Olga Díaz Castello, Juan Moya Amoros, Pedro Barrios Sánchez, David Coroleu Lletget, Mª Antonia Lequerica Cabello, Joan Borras Marcet, Sandra Mecho Meca, Isabel Escape, Javier Martinez-Agea, Estefania Garcia, Marta Ferrer, Xavier Puig Torrus
INTRODUCTION: Analysis of circulating tumor DNA (ctDNA), also known as liquid biopsy, has been postulated to be a useful test in the prognostication, molecular profiling, and monitoring of cancer patients. In this series we aimed to analyze the concordance between the mutation status of formalin-fixed paraffin-embedded (FFPE) tumor samples and matched ctDNA, considering tumor molecular profiling as the gold standard technique. METHODS: This retrospective study included cancer patients with complete diagnostics and gene mutations detected in a previous FFPE tumor tissue Next-Generation Sequencing (NGS) study with a matched frozen plasma sample available for an NGS ctDNA assay...
July 2022: Revista Española de Patología