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https://www.readbyqxmd.com/read/28100488/kinetic-analyses-of-vasculogenesis-inform-mechanistic-studies
#1
Kaela M Varberg, Seth Winfree, Chenghao Chu, Wanzhu Tu, Emily K Blue, Cassandra R Gohn, Kenneth W Dunn, Laura S Haneline
Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell (EPC) functionality. However, current assays lack kinetic measurements. To address this issue, new approaches were developed to quantitatively assess in vitro endothelial colony forming cell (ECFC) network formation in real time. Eight parameters of network structure were quantified using novel Kinetic Analysis of Vasculogenesis (KAV) software...
January 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28079273/abnormal-fetal-muscle-forces-result-in-defects-in-spinal-curvature-and-alterations-in-vertebral-segmentation-and-shape
#2
Rebecca A Rolfe, James H Bezer, Tyler Kim, Ahmed Z Zaidon, Michelle L Oyen, James C Iatridis, Niamh C Nowlan
The incidence of congenital spine deformities, including congenital scoliosis, kyphosis and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. There is a limited understanding of the influence of fetal movements on spinal development, despite the fact that mechanical forces have been shown to play an essential role in skeletal development of the limb. This study investigates the effects of muscle forces on spinal curvature, vertebral segmentation and vertebral shape by inducing rigid or flaccid paralysis in the embryonic chick...
January 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28074994/-normoglycemic-diabetic-ketoacidosis-in-pregnancy-report-of-one-case
#3
Margarita Rivas M, Pamela Belmar Z, Pilar Durruty A, Lilian Sanhueza M, Gloria López S
Normoglycemic diabetic ketoacidosis should be suspected in pregnant women presenting nausea, vomiting, abdominal pain and anorexia. We report a 39 years old woman with a 32 weeks pregnancy who sought emergency care due to hyperemesis. She was hospitalized with the following diagnoses: pregnancy hypertension syndrome, gestational diabetes, morbid obesity and poor prenatal control. The evaluation of the feto-placental unit showed perception of fetal movements, non-reactive non-stress baseline record and a biophysical profile of 6/8...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28043184/perceived-fetal-movement-count-as-a-traditional-but-essential-tool-for-evaluating-fetal-health-some-additions-and-japanese-obstetricians-and-pediatricians-view
#4
Shigeki Matsubara, Daisuke Matsubara, Hironori Takahashi, Yosuke Baba
No abstract text is available yet for this article.
January 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28030594/understanding-misclassification-between-neonatal-deaths-and-stillbirths-empirical-evidence-from-malawi
#5
Li Liu, Henry D Kalter, Yue Chu, Narjis Kazmi, Alain K Koffi, Agbessi Amouzou, Olga Joos, Melinda Munos, Robert E Black
Improving the counting of stillbirths and neonatal deaths is important to tracking Sustainable Development Goal 3.2 and improving vital statistics in low- and middle-income countries (LMICs). However, the validity of self-reported stillbirths and neonatal deaths in surveys is often threatened by misclassification errors between the two birth outcomes. We assessed the extent and correlates of stillbirths being misclassified as neonatal deaths by comparing two recent and linked population surveys conducted in Malawi, one being a full birth history (FBH) survey, and the other a follow-up verbal/social autopsy (VASA) survey...
2016: PloS One
https://www.readbyqxmd.com/read/28017280/nutritional-beliefs-and-practices-among-diabetic-pregnant-mothers-in-a-tertiary-care-hospital-in-bangladesh
#6
Ummy Salma Munni, Sharmin Hossain, Kazi Rumana Ahmed
BACKGROUND & AIM: Pregnant mothers with diabetes, especially in developing countries, are particularly prone to suffer from dietary imbalances due to superstitions and irrational beliefs and practices. The study aimed to explore the existing beliefs and practices related to food intake among Bangladeshi diabetic pregnant mothers. MATERIAL & METHODS: A cross-sectional study was conducted among 200 diabetic pregnant mothers (age in yrs, M±SD, 30±4), selected purposively from outpatient department of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders...
December 13, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27997256/ultrasound-functional-evaluation-of-fetuses-with-myelomeningocele-study-of-the-interpretation-of-results
#7
A Maroto, T Illescas, M Meléndez, S Arévalo, C Rodó, J L Peiró, M Belfort, A Cuxart, E Carreras
OBJECTIVE: To assess the reliability of the interpretation of a new technique for the ultrasound evaluation of the level of neurological lesion in fetuses with myelomeningocele. METHODS: Observational study including myelomeningocele fetuses, referred to our center for the sonographic assessment of the fetal lower-limb movements, made and recorded by an expert in Maternal-fetal medicine and a specialist in Rehabilitation. Two observers, with different levels of expertise and blinded to each other's results, interpreted each recorded scan two different times...
December 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27987340/ethnic-analogies-and-differences-in-fetal-heart-rate-variability-signal-a-retrospective-study
#8
Salvatore Tagliaferri, Francesca Giovanna Esposito, Rosa Fagioli, Marco Di Cresce, Lucia Sacchi, Maria Gabriella Signorini, Marta Campanile, Pasquale Martinelli, Giovanni Magenes
AIM: We aimed to analyze computerized cardiotocographic (cCTG) parameters (including fetal heart rate baseline, short-term variability, Delta, long-term irregularity [LTI], interval index [II], low frequency [LF], movement frequency [MF], high frequency [HF], and approximate entropy [ApEn]) in physiological term pregnancies in order to correlate them with ethnic differences. The clinical meaning of numerical parameters may explain physiological or paraphysiological phenomena that occur in fetuses of different ethnic origins...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27987045/continuous-fetal-head-flexion-as-a-marker-for-prenatal-diagnosis-of-lethal-multiple-pterygium-syndrome-a-case-report
#9
Akihiro Hasegawa, Mieko Hanaoka, Takeshi Murakoshi
Lethal multiple pterygium syndrome (LMPS) is a fatal hereditary disease associated with abnormalities such as pterygium-induced congenital contractures. Fetal hydrops is present in more than half of all patients with LMPS, and all patients with LMPS are either stillborn or die in the early neonatal period. Ultrasonography findings for the prenatal diagnosis of LMPS include the detection of cutaneous webbing at multiple joints, multiple joint contractures, absent limb movement, and increased nuchal translucency...
December 16, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27984230/transversus-abdominis-plane-block-versus-wound-infiltration-for-analgesia-after-cesarean-delivery-a-randomized-controlled-trial
#10
Mohamed Mohamed Tawfik, Yaser Mohamed Mohamed, Rania Elmohamadi Elbadrawi, Mostafa Abdelkhalek, Maiseloon Mostafa Mogahed, Hanaa Mohamed Ezz
BACKGROUND: Transversus abdominis plane (TAP) block and local anesthetic wound infiltration provide analgesia after cesarean delivery. Studies comparing the 2 techniques are scarce, with conflicting results. This double-blind, randomized controlled trial aimed to compare bilateral ultrasound-guided TAP block with single-shot local anesthetic wound infiltration for analgesia after cesarean delivery performed under spinal anesthesia. We hypothesized that the TAP block would decrease postoperative cumulative fentanyl consumption at 24 hours...
December 15, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27975360/-denial-of-pregnancy
#11
Peter Rott
With an incidence of 1:500, denial of pregnancy is a rather frequent incident in obstetrics. Strikingly, in our society, this issue is placed under a taboo. Reasons might be our moral values and socialization. Since pregnancy and motherhood have to be associated with joy, other sensations are often perceived as socially not accepted and thus denied. A similar phenomenon exists e. g. with postnatal depression.In all existing studies on denial of pregnancy, it was proven that there are no significant at-risk groups...
December 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27938874/rationale-study-protocol-and-the-cluster-randomization-process-in-a-controlled-trial-including-40-000-women-investigating-the-effects-of-mindfetalness
#12
Ingela Rådestad, Anna Akselsson, Susanne Georgsson, Helena Lindgren, Karin Pettersson, Gunnar Steineck
BACKGROUND: Shortening pre-hospital delay may decrease stillbirth rates and rates of babies born with a compromised health. Stillbirth may be preceded by a decrease in fetal movements. Mindfetalness has been developed as a response to the shortcomings of kick-counting for the monitoring of fetal movements by the pregnant woman. We do not know if practicing Mindfetalness may diminish pre-hospital delay. Nor do we know if practicing Mindfetalness may increase or decrease the percentage of women seeking health care for unfounded, from a medical perspective, worry for her fetus' well-being...
December 2016: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/27911332/type-0-spinal-muscular-atrophy-further%C3%A2-delineation-of-prenatal-and%C3%A2-postnatal-features-in-16-patients
#13
Sarah Grotto, Jean-Marie Cuisset, Stéphane Marret, Séverine Drunat, Patricia Faure, Séverine Audebert-Bellanger, Isabelle Desguerre, Vincent Flurin, Anne-Gaëlle Grebille, Anne-Marie Guerrot, Hubert Journel, Gilles Morin, Ghislaine Plessis, Sylvain Renolleau, Joëlle Roume, Brigitte Simon-Bouy, Renaud Touraine, Marjolaine Willems, Thierry Frébourg, Eric Verspyck, Pascale Saugier-Veber
BACKGROUND: Spinal muscular atrophy (SMA) is caused by homozygous inactivation of the SMN1 gene. The SMN2 copy number modulates the severity of SMA. The 0SMN1/1SMN2 genotype, the most severe genotype compatible with life, is expected to be associated with the most severe form of the disease, called type 0 SMA, defined by prenatal onset. OBJECTIVE: The aim of the study was to review clinical features and prenatal manifestations in this rare SMA subtype. METHODS: SMA patients with the 0SMN1/1SMN2 genotype were retrospectively collected using the UMD-SMN1 France database...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27875852/computerized-cardiotocography-analysis-comparison-among-several-parental-ethnic-origins
#14
Di Tommaso Mariarosaria, Martello Giulia, Kanninen Tomi, Perelli Federica, Iannuzzi Laura, Sisti Giovanni
Objective We speculate that genetic racial disparity exists in fetal life and can be detected by modern computerized cardiotocography (cCTG). Methods This is a retrospective study comparing the results of the cCTG of pregnant patients at 37-42 weeks according to the parental ethnicity (black versus white). A cCTG was performed to analyze the variables of fetal heart rate (FHR). The cCTG variables analyzed were: percentage of signal loss; number of contractions; basal FHR; number of accelerations; number of decelerations; length of high variation episodes; short-term variability (STV); total trace duration time; and number of fetal active movements...
November 22, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27853327/the-effects-of-maternal-opium-abuse-on-fetal-heart-rate-using-non-stress-test
#15
Fatemeh Keikha, Fahimeh Ghotbizadeh Vahdani, Sahar Latifi
BACKGROUND: Opium is one of the most commonly abused opiates in developing countries including Iran. Considering the importance of maternal health on the newborn, we aimed to assess the effect of opium abuse on fetal heart rate (FHR) characteristics in a sample of pregnant women in Zahedan, Southeast Iran. METHODS: This cross-sectional study was done on 100 pregnant women referring to Ali-Ibn-Abi Talib Hospital in Zahedan, during 2011-2013. The participants were divided into two groups comprising of opium abusers and healthy individuals...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27819173/the-effect-of-music-therapy-on-the-cardiac-activity-parameters-of-a-fetus-in-a-cardiotocographic-examination
#16
Grażyna Gebuza, Agnieszka Dombrowska, Marzena Kaźmierczak, Małgorzata Gierszewska, Estera Mieczkowska
OBJECTIVE: The assessment of cardiac parameters of the fetus in cardiotocographic record of pregnant women listening to Classical music. STUDY DESIGN: 60 NST records with no musical stimulation and 30 NST records during a 15-minute auditive stimulation with Wolfgang Amadeus Mozart's "Turkish March" as well as 30 NST records during Johann Strauss's "Tritsch-Tratsch Polka" were performed for the study. The average stage of the responders' pregnancy was the 36rd week, the lowest - the 27th week, the highest - 41st...
November 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27815938/visualization-and-quantitation-of-fetal-movements-by-real-time-three-dimensional-ultrasound-with-live-xplane-imaging-in-the-first-trimester-of-pregnancy
#17
Ye Lu, Taizhu Yang, Hong Luo, Feng Deng, Qianyun Cai, Weiwei Sun, Hao Song
AIM: To prove whether real-time three-dimensional (3D) ultrasound with live xPlane imaging is better in observing fetal movements than standard ultrasound imaging. METHODS: 50 healthy women with singleton pregnancies (22-43 years old) at 11 to 14 weeks of gestation underwent real-time 3D ultrasound examination with live xPlane imaging from July 2014 to February 2015. The incidence and frequency of 10 fetal movement patterns in 10 minutes were evaluated, including general movements (GMs), isolated arm movements, isolated leg movements, hiccup, stretching, breathing, startle, jaw opening, isolated head retroflexion, and isolated head anteflexion...
October 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/27779913/estrogen-suppresses-interaction-of-melanocortin-2-receptor-and-its-accessory-protein-in-the-primate-fetal-adrenal-cortex
#18
Jeffery S Babischkin, Graham W Aberdeen, Gerald J Pepe, Eugene D Albrecht
We have shown that fetal adrenal fetal zone (FZ) volume and serum dehydroepiandrosterone sulfate (DHAS) levels were increased, whereas definitive and transitional zone (DZ/TZ) volume was unaltered, in baboons in which estrogen levels were suppressed by the administration of the aromatase inhibitor letrozole. The interaction of the melanocortin 2 receptor (MC2R) with its accessory protein (MRAP) is essential for trafficking MC2R to the adrenal cell surface for binding to ACTH. The present study determined whether the estrogen-dependent regulation of fetal adrenocortical development is mediated by ACTH and/or expression/interaction of MC2R and MRAP...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27776846/-prevention-of-preterm-birth-complications-by-antenatal-corticosteroid-administration
#19
T Schmitz
OBJECTIVE: To evaluate short- and long-term benefits and risks associated with antenatal administration of a single course of corticosteroids and the related strategies: multiple and rescue courses. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: Antenatal administration of a single course of corticosteroids before 34 weeks of gestation is associated in the neonatal period with a significant reduction of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and death (LE1), and in possibly childhood with a reduction of cerebral palsy and increased psychomotor development index and intact survival (LE3)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27762439/identification-of-klhl40-mutations-by-targeted-next-generation-sequencing-facilitated-a-prenatal-diagnosis-in-a-family-with-three-consecutive-affected-fetuses-with-fetal-akinesia-deformation-sequence
#20
Tai-Heng Chen, Xia Tian, Pao-Lin Kuo, Hui-Ping Pan, Lee-Jun C Wong, Yuh-Jyh Jong
BACKGROUND: Fetal akinesia deformation sequence (FADS) refers to a broad spectrum of disorder with the absent fetal movement as the unifying feature. The etiology of FADS is heterogeneous, and the majority remains unknown. Prenatal diagnosis of FADS because of neuromuscular origin has relied on clinical features and fetal muscle pathology, which can be unrevealing. The recent advance of next-generation sequencing (NGS) can provide definitive molecular diagnosis effectively. METHODS AND RESULTS: An 18-week-old fetus presented with akinesia and multiple contractures of joints...
December 2016: Prenatal Diagnosis
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