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Dermatopathology

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https://www.readbyqxmd.com/read/27892931/the-influence-of-tumor-regression-solar-elastosis-and-patient-age-on-pathologists-interpretation-of-melanocytic-skin-lesions
#1
Linda Titus, Raymond L Barnhill, Jason P Lott, Michael W Piepkorn, David E Elder, Paul D Frederick, Heidi D Nelson, Patricia A Carney, Stevan R Knezevich, Martin A Weinstock, Joann G Elmore
It is not known whether patient age or tumor characteristics such as tumor regression or solar elastosis influence pathologists' interpretation of melanocytic skin lesions (MSLs). We undertook a study to determine the influence of these factors, and to explore pathologist's characteristics associated with the direction of diagnosis. To meet our objective, we designed a cross-sectional survey study of pathologists' clinical practices and perceptions. Pathologists were recruited from diverse practices in 10 states in the United States...
November 28, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27859475/correlation-between-histopathologic-features-and-likelihood-of-identifying-superficial-dermatophytosis-with-periodic-acid-schiff-diastase-staining-a-cohort-study
#2
Michael Z Wang, Ruifeng Guo, Julia S Lehman
BACKGROUND: Periodic Acid Schiff-Diastase (PAS-D) staining is used routinely in dermatopathology. Conventionally, parakeratosis or intracorneal neutrophils justify use of PAS-D stain to identify dermatophytosis. We aimed to investigate the histopathological features of superficial dermatophytosis. METHODS: Skin biopsies with PAS-D stain were retrospectively reviewed by a blinded dermatopathologist. Histopathologic findings in cases with dermatophytosis were compared to those without...
November 17, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27836252/clinicopathological-study-of-47-cases-of-sebaceoma
#3
F Bourlond, C Velter, B Cribier
BACKGROUND: Sebaceoma is a rare and poorly understood form of sebaceous tumour, and it is of great significance since it may reveal Muir-Torre syndrome (MTS). Herein, we present a series of cases with details of the histopathological appearance. PATIENTS AND METHODS: We examined records of cases labelled as sebaceous tumour recorded at the Strasbourg Dermatopathology Laboratory between 1991 and 2015. We include cases of benign sebaceous tumour predominantly involving immature basophilic cells...
November 8, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27836251/-balloon-cell-nevus-correlation-between-dermatopathology-and-dermatoscopy
#4
P Huet, G Barnéon, B Cribier
No abstract text is available yet for this article.
November 8, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27778322/use-of-the-term-rule-out-in-requisition-forms-may-cause-diagnostic-delays-in-dermatopathology-practice
#5
Yara Abdou, Christine Lohse, Nneka I Comfere
BACKGROUND: Timely pathologic diagnosis relies on the communication of specific clinical information in the requisition form (RF). Clinical information may use nonspecific terms such as "rule out", the use of which may result in diagnostic delays and the unnecessary application of pathology stains and sections. OBJECTIVE: This study was designed to evaluate the relationship between use of the term "rule out" and time to diagnosis, and the use of additional pathology stains and sections in integrated and non-integrated dermatopathology practices...
October 25, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27763901/extraocular-sebaceous-carcinoma-a-clinicopathologic-reassessment
#6
Nicole M Candelario, Julio E Sánchez, Jorge L Sánchez, Rafael F Martín-García, Nicole M Rochet
Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. More cases occurred in men (60%), with a mean age at diagnosis of 65.8 years (range 39-99 years). Neoplasms were histopathologically classified as well-differentiated (22%), moderately differentiated (67%), and poorly differentiated (11%)...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27755208/cutaneous-metastasis-from-sacral-chordoma
#7
Kristyna Gleghorn, Brandon Goodwin, Ramon Sanchez
Chordoma is a rare primary bone malignancy of notochord origin, representing 1-4% of malignant bone tumors. Typically, chordomas follow a slow progressive course with aggressive local extension, multiple recurrences, and metastases. Of particular interest to this case, cutaneous metastasis is exceedingly rare. Diagnosis of this entity can be a challenge due to the rarity of chordoma, as well as the infrequent presentation of distant cutaneous metastasis and non-specific clinical skin findings. We report a case of a 61-year-old male with a history of sacral chordoma treated by wide local excision 8 years prior to presentation developed a nodule on his scalp for 6 weeks...
October 14, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27749545/the-influence-of-a-gene-expression-signature-on-the-diagnosis-and-recommended-treatment-of-melanocytic-tumors-by-dermatopathologists
#8
Clay J Cockerell, Jaime Tschen, Brent Evans, Emily Bess, John Kidd, Kathryn A Kolquist, Colleen Rock, Loren E Clarke
It is well documented that histopathologic examination is sometimes inadequate for accurate and reproducible diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature has been clinically validated as an adjunctive diagnostic test to differentiate benign nevi from malignant melanomas. This study aimed to quantify the impact of this test on diagnosis and treatment recommendations made by dermatopathologists.Diagnostically challenging melanocytic lesions encountered during routine dermatopathology practice were submitted for gene expression testing and received a melanoma diagnostic score (MDS)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27742174/validation-of-diagnostic-accuracy-with-whole-slide-imaging-compared-with-glass-slide-review-in-dermatopathology
#9
Kabeer K Shah, Julia S Lehman, Lawrence E Gibson, Christine M Lohse, Nneka I Comfere, Carilyn N Wieland
BACKGROUND: Teledermatopathology has evolved from static images to whole slide imaging (WSI), which allows for remote viewing and manipulation of tissue sections. Previous studies of WSI in teledermatopathology predated College of American Pathologists (CAP) telepathology validation guidelines. OBJECTIVE: We conducted a comprehensive retrospective WSI validation study of routine dermatopathology cases, adhering to CAP guidelines. METHOD: In all, 181 consecutive cases arranged into 3 categories (inflammatory, melanocytic, nonmelanocytic proliferations) were reviewed by 3 board-certified dermatopathologists via traditional microscopy (TM) and WSI...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27720563/contributions-of-dr-louis-pepper-dehner-to-the-art-of-cutaneous-pathology-the-first-pediatric-dermatopathologist
#10
Alejandro A Gru, M D Horacio Maluf
Dr. Louis "Pepper" Dehner has been one of the most influential surgical pathologists of the last century. Authoring more than 450 publications, he is the premier modern pediatric pathologist. Perhaps, an area that he is less recognized and in which we would like to describe his contributions, is his role as a creator of the art of pediatric dermatopathology. Dr. Dehner has had at least 50 major publications describing, discovering, and orienting the discipline in the fields of fibrohistiocytic disorders of childhood, vascular tumors, and histiocytosis among many others...
September 5, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27717008/-hints-in-the-horn-diagnostic-clues-in-the-stratum-corneum
#11
José Carlos Cardoso, Ophelia Veraitch, Raffaele Gianotti, Gerardo Ferrara, Carlo F Tomasini, Manuraj Singh, Iris Zalaudek, Catherine M Stefanato
The stratum corneum or horny layer is the uppermost layer of the epidermis, and is mainly responsible for the skin's barrier function. In spite of its complexity at the ultrastructural and molecular level, the features accessible to visualization on conventional histology are relatively limited. Nevertheless, knowledge of subtle clues that one may observe in the stratum corneum can prove useful in a wide range of situations in dermatopathology. We herein review a selection of common and rare entities in which the horny layer may reveal significantly important hints for the diagnosis...
October 7, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27688931/rates-of-provision-of-clinical-information-in-the-skin-biopsy-requisition-form-and-corresponding-encounter-visit-note
#12
Meredith A Olson, Christine M Lohse, Nneka I Comfere
BACKGROUND: The skin biopsy requisition form (RF) serves as a key communication tool for transfer of relevant information related to skin biopsy between clinicians and pathologists. Clinical information in the skin biopsy RF is frequently missing or incomplete. OBJECTIVE: To determine the rates of provision of critical clinical information necessary for histopathologic interpretation in the skin biopsy RF and encounter visit note (EVN). METHODS: A retrospective review of 300 RFs and corresponding EVNs from May 1 to 7, 2012, in a tertiary care dermatology practice...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27682637/primary-scalp-alopecia-new-histopathological-tools-new-concepts-and-a-practical-guide-to-diagnosis
#13
Athanassios Kolivras, Curtis Thompson
The diagnosis of primary scalp alopecia remains one of the most challenging fields in dermatopathology. In this review, we would like to connect the established classification of primary alopecia into scarring (cicatricial) and non-scarring (non-cicatricial) with current concepts. We introduce a simplified pathway for the diagnosis of the most common causes of alopecia, including a discussion of tissue processing techniques and use of immunohistochemistry.
September 28, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27680303/-zoon-s-balanitis-correlation-between-dermatopathology-and-dermoscopy
#14
P Huet, G Barnéon, B Cribier
No abstract text is available yet for this article.
September 24, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27613299/-report-of-the-dermatopathology-working-group-berlin%C3%A2-2016
#15
P Meister
No abstract text is available yet for this article.
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27570202/basosquamous-carcinoma-dermoscopic-clues-to-diagnosis
#16
Bengu Nisa Akay, Secil Saral, Aylin O Heper, Cengizhan Erdem, Cliff Rosendahl
Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the published work, except one study. The aim of the present study was to better identify and clarify the dermoscopic findings of BSC in the largest group of patients in the published work and to describe its dermoscopic features according to histopathologically BCC-dominant, SCC-dominant and intermediate categories...
August 29, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27512181/approach-to-cutaneous-lymphoid-infiltrates-when-to-consider-lymphoma
#17
REVIEW
Yann Vincent Charli-Joseph, Michelle Gatica-Torres, Laura Beth Pincus
Cutaneous lymphoid infiltrates (CLIs) are common in routine dermatopathology. However, differentiating a reactive CLI from a malignant lymphocytic infiltrate is often a significant challenge since many inflammatory dermatoses can clinically and/or histopathologically mimic cutaneous lymphomas, coined pseudolymphomas. We conducted a literature review from 1966 to July 1, 2015, at PubMed.gov using the search terms: Cutaneous lymphoma, cutaneous pseudolymphoma, cutaneous lymphoid hyperplasia, simulants/mimics/imitators of cutaneous lymphomas, and cutaneous lymphoid infiltrates...
July 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27506854/the-role-of-dog1-immunohistochemistry-in-dermatopathology
#18
Keisuke Goto
BACKGROUND: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors. METHODS: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues. RESULTS: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum...
August 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27500958/mucin-as-a-diagnostic-clue-in-dermatopathology
#19
Angel Fernandez-Flores, Marcela Saeb-Lima
Mucins are high-molecular weight glycoproteins typically found in normal skin in small amounts. There are several reports regarding different types of cutaneous mucinosis. In this report, we discuss mucins in dermatopathology as a diagnostic clue of some well-known entities and some less frequent cutaneous diseases. We also emphasize mucin as a sign in the differential diagnosis between conditions that show histopathological overlap. Lastly, we discuss the locations and circumstances in which mucin could be considered almost normal or physiological...
August 8, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27494987/cutaneous-manifestations-in-inflammatory-bowel-disease-a-single-institutional-study-of-non-neoplastic-biopsies-over-13-years
#20
Jennifer S Ko, Georgina Uberti, Karl Napekoski, Deepa Patil, Steven D Billings
BACKGROUND: Skin is commonly affected by extraintestinal manifestations of inflammatory bowel disease (IBD), but a controlled, systematic histopathologic analysis of cutaneous lesions is lacking. METHODS: 4147 classified IBD (Crohn disease (CD) or ulcerative colitis (UC); 2000-2013) resections were cross referenced with skin biopsies. Associated non-neoplastic skin biopsies were categorized by basic reaction pattern and neutrophilic versus granulomatous. RESULTS: Of 4147 patients, 133 had non-neoplastic skin biopsies (106/2772, 3...
August 6, 2016: Journal of Cutaneous Pathology
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