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Dermatopathology

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https://www.readbyqxmd.com/read/28040330/quality-assurance-of-anatomic-pathology-diagnoses-comparison-of-alternate-approaches
#1
Lester J Layfield, Shellaine R Frazier
OBJECTIVES: Traditionally, a 10% review has been the basis for quality assurance programs in anatomic pathology. The effectiveness of such reviews has been questioned and alternative methodologies suggested. The study investigates the error detection rates for four quality assurance protocols. METHODS: The detection rate for diagnostic errors in surgical pathology was calculated over a one year period using four different review procedures comprising: random 10% review, correlation of internal and external diagnoses following solicited external expert opinion, correlation of internal diagnoses with outside diagnoses in cases sent for review at a second institution treating the patient along with a focused review of dermatopathology cases over a 3 month period...
November 11, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28039770/body-mass-index-height-and-early-onset-basal-cell-carcinoma-in-a-case-control-study
#2
Yanchang Zhang, Brenda Cartmel, Courtney C Choy, Annette M Molinaro, David J Leffell, Allen E Bale, Susan T Mayne, Leah M Ferrucci
INTRODUCTION: Basal cell carcinoma (BCC) is the most common malignancy in the US. Body mass index (BMI) and height have been associated with a variety of cancer types, yet the evidence regarding BCC is limited. Therefore, we evaluated BMI and height in relation to early-onset BCC (under age 40) and explored the potential role of ultraviolet (UV) radiation exposure and estrogen-related exposures in the BMI-BCC relationship. METHODS: BCC cases (n=377) were identified through a central dermatopathology facility in Connecticut...
December 28, 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/28033156/tubulopapillary-cystic-adenoma-with-apocrine-differentiation-a-unifying-concept-for-syringocystadenoma-papilliferum-apocrine-gland-cyst-and-tubular-papillary-adenoma
#3
Shin-Ichi Ansai, Takashi Anan, Takaya Fukumoto, Hidehisa Saeki
Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillary adenoma (TPA) with apocrine differentiation are defined as proliferations of apocrine epithelium with myoepithelial cells. At Sapporo Dermatopathology Institute, we retrieved 308 benign neoplastic lesions diagnosed as SCAP, AGC, or TPA and combinations of these entities. Among the 308 lesions, 202 (66%) exhibited features of only one type, of which 144 (47%) were AGC, 39 (13%) were TPA, and 19 (6%) were SCAP...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28030717/pathologic-evaluation-of-skin-tumors-with-ex-vivo-dermoscopy-with-derm-dotting
#4
Marc Haspeslagh, Isabelle Hoorens, Nele Degryse, Ine De Wispelaere, Annemarie Degroote, Sarah Van Belle, Jan Verboven, Katrien Vossaert, Fabio Facchetti, Jo Van Dorpe, Sofie De Schepper, Lieve Brochez
Importance: Ex vivo dermoscopy (EVD) with derm dotting (DD) improves clinicopathologic correlation and the quality of diagnosis in skin tumors. Objective: To compare the diagnostic performance of the standard method of skin biopsy processing with the practice of EVD with DD. Design, Setting, and Participants: This retrospective study compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a standard method of processing with 8584 biopsy specimens examined in 2015 with EVD and DD...
December 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/28028116/measures-of-completeness-and-accuracy-of-clinical-information-in-skin-biopsy-requisition-forms-an-analysis-of-249-cases
#5
Ryan C Romano, Paul J Novotny, Jeff A Sloan, Nneka I Comfere
OBJECTIVES: To define indices of completeness and accuracy of clinical information in the skin biopsy requisition form (RF) and correlate them with health care delivery outcomes and pathology service utilization. METHODS: RFs in our pathology information system were reviewed and assessed for the presence of 10 clinical elements considered critical for dermatopathologic diagnosis. Accuracy was determined by reviewing corresponding clinical notes. RESULTS: In total, 249 RFs were reviewed...
December 27, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28002099/achille-civatte-a-master-of-the-microscope
#6
Jannett Nguyen, Dorota Z Korta
Achille Civatte (1877-1956) was one of the most highly regarded dermatologists of the 20th century. We provide a succinct account of Civatte's academic life and contributions to the field of dermatopathology, in addition to briefly discussing his son, Jean Civatte, who himself became a highly regarded dermatologist.
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27991691/morphology-of-rare-exogenous-materials-in-dermatopathology
#7
Angel Fernández-Flores
Dermatopathologists are occasionally challenged by exogenous materials found in their biopsies. Recognition of most of the structures and morphological parts of foreign materials is not always easy because most of the literature thus far has focused on the study of the histological and histopathological aspects of human tissues, as well as on the granulomatous response elicited by such foreign bodies. However, there are some cases of rare exogenous material in biopsies, mainly published as case reports; and dermatopathologists often lose precious time searching for information about such cases...
December 19, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27990395/dermatopathology-quiz-keratotic-papules-of-the-palms
#8
Alex Flamm, Qiang Xie, Dennis C Polley, Lana Vanstory, Dirk M Elston
No abstract text is available yet for this article.
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27892931/the-influence-of-tumor-regression-solar-elastosis-and-patient-age-on-pathologists-interpretation-of-melanocytic-skin-lesions
#9
Linda Titus, Raymond L Barnhill, Jason P Lott, Michael W Piepkorn, David E Elder, Paul D Frederick, Heidi D Nelson, Patricia A Carney, Stevan R Knezevich, Martin A Weinstock, Joann G Elmore
It is not known whether patient age or tumor characteristics such as tumor regression or solar elastosis influence pathologists' interpretation of melanocytic skin lesions (MSLs). We undertook a study to determine the influence of these factors, and to explore pathologist's characteristics associated with the direction of diagnosis. To meet our objective, we designed a cross-sectional survey study of pathologists' clinical practices and perceptions. Pathologists were recruited from diverse practices in 10 states in the United States...
November 28, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27859475/correlation-between-histopathologic-features-and-likelihood-of-identifying-superficial-dermatophytosis-with-periodic-acid-schiff-diastase-staining-a-cohort-study
#10
Michael Z Wang, Ruifeng Guo, Julia S Lehman
BACKGROUND: Periodic acid Schiff-diastase (PAS-D) staining is used routinely in dermatopathology. Conventionally, parakeratosis or intracorneal neutrophils justify use of PAS-D stain to identify dermatophytosis. We aimed to investigate the histopathological features of superficial dermatophytosis. METHODS: Skin biopsies with PAS-D stain were retrospectively reviewed by a blinded dermatopathologist. Histopathologic findings in cases with dermatophytosis were compared with those without...
February 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27836252/clinicopathological-study-of-47-cases-of-sebaceoma
#11
F Bourlond, C Velter, B Cribier
BACKGROUND: Sebaceoma is a rare and poorly understood form of sebaceous tumour, and it is of great significance since it may reveal Muir-Torre syndrome (MTS). Herein, we present a series of cases with details of the histopathological appearance. PATIENTS AND METHODS: We examined records of cases labelled as sebaceous tumour recorded at the Strasbourg Dermatopathology Laboratory between 1991 and 2015. We include cases of benign sebaceous tumour predominantly involving immature basophilic cells...
December 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27836251/-balloon-cell-nevus-correlation-between-dermatopathology-and-dermatoscopy
#12
P Huet, G Barnéon, B Cribier
No abstract text is available yet for this article.
November 8, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27778322/use-of-the-term-rule-out-in-requisition-forms-may-cause-diagnostic-delays-in-dermatopathology-practice
#13
Yara Abdou, Christine Lohse, Nneka I Comfere
BACKGROUND: Timely pathologic diagnosis relies on the communication of specific clinical information in the requisition form (RF). Clinical information may use nonspecific terms such as "rule out", the use of which may result in diagnostic delays and the unnecessary application of pathology stains and sections. OBJECTIVE: This study was designed to evaluate the relationship between use of the term "rule out" and time to diagnosis, and the use of additional pathology stains and sections in integrated and non-integrated dermatopathology practices...
January 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27763901/extraocular-sebaceous-carcinoma-a-clinicopathologic-reassessment
#14
Nicole M Candelario, Julio E Sánchez, Jorge L Sánchez, Rafael F Martín-García, Nicole M Rochet
Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. More cases occurred in men (60%), with a mean age at diagnosis of 65.8 years (range 39-99 years). Neoplasms were histopathologically classified as well-differentiated (22%), moderately differentiated (67%), and poorly differentiated (11%)...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27755208/cutaneous-metastasis-from-sacral-chordoma
#15
Kristyna Gleghorn, Brandon Goodwin, Ramon Sanchez
Chordoma is a rare primary bone malignancy of notochord origin, representing 1-4% of malignant bone tumors. Typically, chordomas follow a slow progressive course with aggressive local extension, multiple recurrences, and metastases. Of particular interest to this case, cutaneous metastasis is exceedingly rare. Diagnosis of this entity can be a challenge due to the rarity of chordoma, as well as the infrequent presentation of distant cutaneous metastasis and non-specific clinical skin findings. We report a case of a 61-year-old male with a history of sacral chordoma treated by wide local excision 8 years prior to presentation developed a nodule on his scalp for 6 weeks...
October 14, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27749545/the-influence-of-a-gene-expression-signature-on-the-diagnosis-and-recommended-treatment-of-melanocytic-tumors-by-dermatopathologists
#16
Clay J Cockerell, Jaime Tschen, Brent Evans, Emily Bess, John Kidd, Kathryn A Kolquist, Colleen Rock, Loren E Clarke
It is well documented that histopathologic examination is sometimes inadequate for accurate and reproducible diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature has been clinically validated as an adjunctive diagnostic test to differentiate benign nevi from malignant melanomas. This study aimed to quantify the impact of this test on diagnosis and treatment recommendations made by dermatopathologists.Diagnostically challenging melanocytic lesions encountered during routine dermatopathology practice were submitted for gene expression testing and received a melanoma diagnostic score (MDS)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27742174/validation-of-diagnostic-accuracy-with-whole-slide-imaging-compared-with-glass-slide-review-in-dermatopathology
#17
Kabeer K Shah, Julia S Lehman, Lawrence E Gibson, Christine M Lohse, Nneka I Comfere, Carilyn N Wieland
BACKGROUND: Teledermatopathology has evolved from static images to whole slide imaging (WSI), which allows for remote viewing and manipulation of tissue sections. Previous studies of WSI in teledermatopathology predated College of American Pathologists (CAP) telepathology validation guidelines. OBJECTIVE: We conducted a comprehensive retrospective WSI validation study of routine dermatopathology cases, adhering to CAP guidelines. METHOD: In all, 181 consecutive cases arranged into 3 categories (inflammatory, melanocytic, nonmelanocytic proliferations) were reviewed by 3 board-certified dermatopathologists via traditional microscopy (TM) and WSI...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27720563/contributions-of-dr-louis-pepper-dehner-to-the-art-of-cutaneous-pathology-the-first-pediatric-dermatopathologist
#18
Alejandro A Gru, M D Horacio Maluf
Dr. Louis "Pepper" Dehner has been one of the most influential surgical pathologists of the last century. Authoring more than 450 publications, he is the premier modern pediatric pathologist. Perhaps, an area that he is less recognized and in which we would like to describe his contributions, is his role as a creator of the art of pediatric dermatopathology. Dr. Dehner has had at least 50 major publications describing, discovering, and orienting the discipline in the fields of fibrohistiocytic disorders of childhood, vascular tumors, and histiocytosis among many others...
September 5, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27717008/-hints-in-the-horn-diagnostic-clues-in-the-stratum-corneum
#19
REVIEW
José Carlos Cardoso, Ophelia Veraitch, Raffaele Gianotti, Gerardo Ferrara, Carlo F Tomasini, Manuraj Singh, Iris Zalaudek, Catherine M Stefanato
The stratum corneum or horny layer is the uppermost layer of the epidermis, and is mainly responsible for the skin's barrier function. In spite of its complexity at the ultrastructural and molecular level, the features accessible to visualization on conventional histology are relatively limited. Nevertheless, knowledge of subtle clues that one may observe in the stratum corneum can prove useful in a wide range of situations in dermatopathology. We herein review a selection of common and rare entities in which the horny layer may reveal significantly important hints for the diagnosis...
October 7, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27688931/rates-of-provision-of-clinical-information-in-the-skin-biopsy-requisition-form-and-corresponding-encounter-visit-note
#20
Meredith A Olson, Christine M Lohse, Nneka I Comfere
BACKGROUND: The skin biopsy requisition form (RF) serves as a key communication tool for transfer of relevant information related to skin biopsy between clinicians and pathologists. Clinical information in the skin biopsy RF is frequently missing or incomplete. OBJECTIVE: To determine the rates of provision of critical clinical information necessary for histopathologic interpretation in the skin biopsy RF and encounter visit note (EVN). METHODS: A retrospective review of 300 RFs and corresponding EVNs from May 1 to 7, 2012, in a tertiary care dermatology practice...
2016: Journal of Pathology Informatics
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