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Feng Zhang Broad

Yan Lin, Fa-Zhan Zhang, Kai Xue, Yi-Zhou Gao, Feng-Biao Guo
Essential genes are those genes of an organism that are considered to be crucial for its survival. Identification of essential genes is therefore of great significance to advance our understanding of the principles of cellular life. We have developed a novel computational method, which can effectively predict bacterial essential genes by extracting and integrating homologous features, protein domain feature, gene intrinsic features and network topological features. By performing the principal component regression (PCR) analysis for Escherichia coli MG1655, we established a classification model with the average area under curve (AUC) value of 0...
February 15, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Cunjing Lv, Xiwen Zhang, Fenglei Niu, Feng He, Pengfei Hao
Understanding how droplet condensation happens plays an essential role for our fundamental insights of wetting behaviors in nature and numerous applications. Since there is a lack of study of the initial formation and growing processes of condensed droplets down to nano-/submicroscale, relevant underlying mechanisms remain to be explored. We report an in situ observation of vapor condensation on nano-/microtextured superhydrophobic surfaces using optical microscopy. An interesting picture of the vapor condensation, from the initial appearance of individual small droplets (≤1 μm) to a Cassie-Baxter wetting state (>30 μm), are exhibited...
February 16, 2017: Scientific Reports
Yueyun Li, Yihe Zhang, Faying Li, Jinhui Feng, Mingdang Li, Lei Chen, Yunhui Dong
Recently early diagnosis of squamous cell carcinoma antigen (SCCA) as a tumor maker of various cancers has increasingly attracted a lot of attention with heightening of incidence rate of cancer. The SCCA with low concentration in human serum should be diluted before detecting. Thus, an immunoassay with high sensitivity is significant for early detecting SCCA. Therefore, a nonenzymatic sandwich-type electrochemical immunosensor herein was conducted to quantitative detection of squamous cell carcinoma antigen (SCCA)...
January 31, 2017: Biosensors & Bioelectronics
Yukun Zhao, Feng Yun, Yi Huang, Shuai Wang, Lungang Feng, Yufeng Li, Maofeng Guo, Wen Ding, Ye Zhang
In this paper, a novel array of quasi-three-dimensional (quasi-3D) bowtie nanoantennas has been investigated numerically and experimentally. A low-cost and facile method has been designed and implemented to fabricate the quasi-3D bowtie nanoantennas. The fabrication processes containing laser patterning and wet etching have demonstrated the advantages of easily tuning the periodic and diameter of microhole arrays. According to the simulated results, the electric and magnetic resonances at visible wavelengths are obtained in the tips and contours of the metamaterials made of the quasi-3D bowtie nanoantennas, respectively...
February 8, 2017: Scientific Reports
Zhi Huang, Fei Zhao, Yonghui Li, Jianwei Zhang, Youzhi Feng
To fully understand the bacterial processes in tomb environments, it is necessary to investigate the details of the bacterial communities present under such oligotrophic conditions. Here, high-throughput sequencing based on partial 16S rRNA gene sequences was used to fully evaluate the bacterial communities at different sites in the tomb of Emperor Yang of the Sui Dynasty. We also aimed to identify the soil factors that were significant related to bacterial diversity and community composition. The results showed the presence of a broad taxonomic diversity that included nine major phyla...
March 2017: Microbiological Research
Zhenpeng Huang, Huaqiu Deng, Changsheng Yang, Qilai Zhao, Yuanfei Zhang, Yuning Zhang, Zhouming Feng, Zhongmin Yang, Mingying Peng, Shanhui Xu
Based on a self-injection locking scheme and the nonlinear amplification effect of a semiconductor optical amplifier, a low intensity noise amplified ultrashort cavity single-frequency fiber laser at 978 nm is demonstrated with a final output power of > 230 mW and a broad temperature range of > 15 °C for single-longitudinal-mode operation. The effective cavity length of the fiber oscillator is less than 6 mm, comprising a 3.5-mm-long highly Yb<sup>3+</sup>-doped phosphate fiber and a pair of fiber Bragg gratings...
January 23, 2017: Optics Express
Hangyu Zhou, Mengchuan Zhao, Xinna Li, Dan Zhang, Shuaifeng Zhou, Chen Chen, Zhishan Feng, Xuejun Ma
Respiratory viruses are recognized as serious causes of morbidity and mortality in lower respiratory tract infections in patients. Isothermal amplification assays are increasingly used in their detection because of their rapidity, simplicity and cost-effectiveness, when compared to traditional molecular diagnostic methods. However, systematic assessment of these assays in the clinical settings is rarely reported. MEDLINE (Pubmed) searches were done analysing subject headings and words in the abstract related to isothermal amplification assay and virus...
February 2, 2017: Archives of Virology
Zhongbo Zhang, Zichun Zhou, Qin Hu, Feng Liu, Thomas P Russell, Xiaozhang Zhu
A small molecule TBTT-1 with 5-(2-ethylhexyl)-1,3-bis(2-(2-ethylhexyl)thieno[3,4-b]thiophen-6-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione (TBTT) as the central moiety was designed and synthesized for solution-processed bulk-heterojunction solar cells. TBTT-1 exhibits a broad absorption with a low optical band gap of approximately 1.53 eV in the thin film. An optimized power conversion efficiency (PCE) of 7.47% with a high short-circuit current of 14.95 mA cm(-2) was achieved with diphenyl ether (DPE) as additive, which is the highest PCE for TPD-based small-molecule solar cells...
February 8, 2017: ACS Applied Materials & Interfaces
Ying-Hong Li, Sheng Tang, Yu-Huan Li, Xin-Yue Cheng, Xin Zhang, Yan-Xiang Wang, Feng Su, Dan-Qing Song
A series of novel 12N-substituted matrinane derivatives were synthesized and evaluated for their activities against coxsackievirus type B3 (CVB3) taking compound 1 as the lead. SAR analysis indicated that the introduction of a suitable heteroaromatic ring on the 12N-atom might be beneficial for the activity. Among them, compound 8a exhibited the highest potency against all CVB serotypes as well as CVA16 with IC50 values ranging from 2.02μM to 7.41μM, indicating a broad-spectrum anti-coxsackieviruse effect...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
Huo Xu, Dong Wu, Yifan Jiang, Rongbo Zhang, Qingzheng Wu, Yiyun Liu, Feng Li, Zai-Sheng Wu
Mutations in Kras gene may be used as a diagnostic marker and a target for treatment of the broad spectrum of human cancers. In this study, we developed a new class of amplification assay, double-hairpin molecular beacon (DHMB)-based cascade rolling circle amplification (RCA), for ultrasensitive and selective detection of Kras gene in a homogenous solution. Specifically, target DNA can hybridize with DHMB and activate cyclical target strand-displacement polymerization (CTDP) and nicking-mediated strand-displacement polymerization (NMDP)...
March 1, 2017: Talanta
Xiaokui Huo, Chao Wang, Zhenlong Yu, Yulin Peng, Shumei Wang, Shengnan Feng, Shouji Zhang, Xiangge Tian, Chengpeng Sun, Kexin Liu, Sa Deng, Xiaochi Ma
Melatonin is present in virtually all organisms from bacteria to mammals, and it exhibits a broad spectrum of biological functions, including synchronization of circadian rhythms and oncostatic activity. Several functions of melatonin are mediated by its membrane receptors but others are receptor-independent. For the latter, melatonin is required to penetrate membrane and enters intracellular compartments. However, the mechanism by which melatonin enters cells remains debatable. In the current study, it was identified that melatonin and its sulfation metabolites were the substrates of oligopeptide transporter (PEPT) 1/2 and organic anion transporter (OAT) 3, respectively...
January 18, 2017: Journal of Pineal Research
Nannan Zhang, Dandan Zhang, Jian-Feng Li
The unpredictability of in planta silencing efficiency of artificial micro RNAs (amiRNAs) has greatly limited the application of the amiRNA technology in basic and applied plant research. This unit describes a simple and robust method called the epitope-tagged protein-based amiRNA (ETPamir) screen for identifying the most effective amiRNA for silencing a particular Arabidopsis gene. After selecting three to four amiRNA candidates designed by the WMD3 web server for the target gene, the silencing efficiencies of the amiRNA candidates can be compared by co-expressing individual amiRNAs with the target mRNA encoding an epitope-tagged target protein in Arabidopsis mesophyll protoplasts...
January 5, 2017: Current Protocols in Molecular Biology
Lai Chen, Yu-Jie Zhu, Zhi-Jin Fan, Xiao-Feng Guo, Zhi-Ming Zhang, Jing-Hua Xu, Ying-Qi Song, Morzherin Y Yurievich, Nataliya P Belskaya, Vasiliy A Bakulev
Strobilurin fungicides play a crucial role in protecting plants against different pathogens and securing food supplies. A series of 1,2,3-thiadiazole and thiazole-based strobilurins were rationally designed, synthesized, characterized, and tested against various fungi. Introduction of 1,2,3-thiadiazole greatly improved the fungicidal activity of the target molecules. Compounds 8a, 8c, 8d, and 10i exhibited a relatively broad spectrum of fungicidal activity. Compound 8a showed excellent activities against Gibberella zeae, Sclerotinia sclerotiorum, and Rhizoctonia cerealis with median effective concentrations (EC50) of 2...
February 1, 2017: Journal of Agricultural and Food Chemistry
Lang Rao, Qian-Fang Meng, Lin-Lin Bu, Bo Cai, Qinqin Huang, Zhi-Jun Sun, Wen-Feng Zhang, Andrew Li, Shi-Shang Guo, Wei Liu, Tza-Huei Wang, Xing-Zhong Zhao
Upconversion nanoparticles (UCNPs) with superior optical and chemical features have been broadly employed for in vivo cancer imaging. Generally, UCNPs are surface modified with ligands for cancer active targeting. However, nanoparticles in biological fluids are known to form a long-lived "protein corona", which covers the targeting ligands on nanoparticle surface and dramatically reduces the nanoparticle targeting capabilities. Here, for the first time, we demonstrated that by coating UCNPs with red blood cell (RBC) membranes, the resulting cell membrane-capped nanoparticles (RBC-UCNPs) adsorbed virtually no proteins when exposed to human plasma...
January 12, 2017: ACS Applied Materials & Interfaces
Hui Zhang, Mengya Li, Jie Li, Guangli Wang, Feng Li, Dayong Xu, Yuan Liu, Minghua Xiong
A natural consortium, named L1, of Rhodococcus sp. JT-3 and Brevundimonas sp. JT-9 was obtained from quizalofop-p-ethyl (QE) polluted soil. The consortium was able to use QE as a sole carbon source for growth and degraded 100mgL(-1) of QE in 60h. Strain JT-3 initiated the catabolism of QE to quizalofop acid (QA), which was used by strain JT-9 as carbon source for growth and to simultaneously feed strain JT-3. A novel esterase EstS-JT, which was responsible for the transformation of QE to QA and essential for the mineralization of QE by the consortium, was cloned from strain JT-3...
December 21, 2016: Journal of Hazardous Materials
Xiangxiang Wang, Jiwei Mao, Yiming Chen, Dongmin Song, Zhendong Gao, Xiuming Zhang, Yanling Bai, Per E J Saris, Hui Feng, Haijin Xu, Mingqiang Qiao
Class IIa bacteriocin pediocin PA-1 has broad-spectrum activity and is a well-characterized candidate food biopreservative. Here, a simple approach is designed to extend the application of pediocin PA-1 in improving the antibacterial activity of electrospun poly(caprolactone) (PCL) grafts through combining PA-1 with HGFI, which is a self-assembled protein with characteristics allowing the modulation of surface properties of other materials originated from Grifola frondosa. Saccharomyces cerevisiae was used as the host for expression of fusion protein PA-1-linker-HGFI (pH) and his-tag purification was used to purify recombinant protein pH...
December 16, 2016: Colloids and Surfaces. B, Biointerfaces
Qiulong Zhang, Huanhuan Lv, Lili Wang, Man Chen, Fangfei Li, Chao Liang, Yuanyuan Yu, Feng Jiang, Aiping Lu, Ge Zhang
Aptamers are single-stranded DNA or RNA oligonucleotides that can interact with target molecules through specific three-dimensional structures. The excellent features, such as high specificity and affinity for target proteins, small size, chemical stability, low immunogenicity, facile chemical synthesis, versatility in structural design and engineering, and accessible for site-specific modifications with functional moieties, make aptamers attractive molecules in the fields of clinical diagnostics and biopharmaceutical therapeutics...
December 18, 2016: International Journal of Molecular Sciences
Li Su, Wenpei Dong, Chengke Wu, Yijun Gong, Yan Zhang, Ling Li, Guojiang Mao, Suling Feng
The synthesized NiCo2O4 mesoporous spheres (MS) displayed intrinsic peroxidase and oxidase-like activity were firstly reported. The catalytic mechanism of the oxidase-like activity of NiCo2O4 MS was analyzed in detail using the electron spin resonance (ESR) method. It is found that NiCo2O4 MS could directly oxidize 3,3',5,5'-tetramethylbenzidine (TMB) but did not produce (1)O2 and ·OH. And the mechanism of the peroxidase-like activity of NiCo2O4 MS was also verified that the oxidation of TMB stemmed from not only ·OH but also (1)O2...
January 25, 2017: Analytica Chimica Acta
Jian-Feng Li, Jia-Xin Zhang, Zhi-Guo Wang, Ying-Jia Yao, Xu Han, You-Long Zhao, Jun-Ping Liu, Shuang-Quan Zhang
Antibacterial peptide CM4 (ABP-CM4) is a natural product isolated from the silkworm Bombyx mori. It is a small cationic peptide with broad-spectrum activities against harmful microorganisms and may be used as a novel food preservative. However, ABP-CM4 lacks tertiary structure in water-like solutions, which makes it more susceptible to proteases and labile when exposed to air. In this study, β-cyclodextrin (β-CD) was chosen to form an inclusion complex with ABP-CM4, which enhanced the physical and chemical properties of ABP-CM4 but did not decrease its antibacterial activity...
April 15, 2017: Food Chemistry
Quan Zhou, Jing-Fan Zhang, Hui Cao, Rui Zhong, Xiu-Feng Hou
2-Arylbenzazoles are promising molecules for potential applications in medicine and material areas. Efficient protocols for direct regioselective functionalization of 2-arylbenzoxazoles are in high demand. Herein, we disclose a general method for selective ortho-olefination of 2-arylbenzo[d]oxazoles with alkenes enabled by versatile Cp*Rh(III) in high yields. This protocol features broad functional group tolerance and high regioselectivity. Intermolecular competition studies and kinetic isotope effect experiments imply that the oxidative olefination process occurs via an electrophilic C-H activation pathway...
December 16, 2016: Journal of Organic Chemistry
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