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https://www.readbyqxmd.com/read/29673353/modulation-of-ovine-sbd-1-expression-by-saccharomyces-cerevisiae-in-ovine-ruminal-epithelial-cells
#1
Xin Jin, Man Zhang, Xue-Min Zhu, Yan-Ru Fan, Chen-Guang Du, Hua-Er Bao, Siri-Guleng Xu, Qiao-Zhen Tian, Yun-He Wang, Yin-Feng Yang
BACKGROUND: The ovine rumen is involved in host defense responses and acts as the immune interface with the environment. The ruminal mucosal epithelium plays an important role in innate immunity and secretes antimicrobial innate immune molecules that have bactericidal activity against a variety of pathogens. Defensins are cationic peptides that are produced by the mucosal epithelia and have broad-spectrum antimicrobial activity. Sheep β-defensin-1 (SBD-1) is one of the most important antibacterial peptides in the rumen...
April 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29673174/inhibition-of-rabies-virus-by-1-2-3-4-6-penta-o-galloyl-%C3%AE-d-glucose-involves-mtor-dependent-autophagy
#2
Zhongzhong Tu, Wenjie Gong, Yan Zhang, Ye Feng, Yan Liu, Changchun Tu
The compound 1,2,3,4,6-penta- O -galloyl-β-d-glucose (PGG), a gallotannin present in various plants such as Rhus chinensis Mill and Paeonia suffruticosa , has a broad spectrum of antiviral effects. The present study investigated its potency against infection of mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited virus titers (50-fold), viral mRNA expression (up to 90%), and protein synthesis in vitro. Importantly, we found that PGG not only suppressed viral adsorption and entry, but also directly inactivated RABV through suppression of autophagy by mediating activation of the mTOR-dependent autophagy signaling pathway...
April 17, 2018: Viruses
https://www.readbyqxmd.com/read/29669288/mutual-stabilization-between-trim9-short-isoform-and-mkk6-potentiates-p38-signaling-to-synergistically-suppress-glioblastoma-progression
#3
Kunpeng Liu, Chuanxia Zhang, Bowen Li, Weihong Xie, Jindong Zhang, Xichen Nie, Peng Tan, Limin Zheng, Song Wu, Yunfei Qin, Jun Cui, Feng Zhi
p38 signaling is broadly involved in controlling inflammation and stress-induced cell death; however, the mechanisms controlling its activity have seldom been studied. Here, we report that TRIM9 short isoform (TRIM9s) potentiates p38 signaling by stabilizing MKK6. Mechanistic studies revealed that TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine. MKK6 could also stabilize TRIM9s by promoting the phosphorylation of TRIM9s at Ser76/80 via p38, thereby blocking the ubiquitin-proteasome pathway...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29666278/deubiquitylation-and-stabilization-of-p21-by-usp11-is-critical-for-cell-cycle-progression-and-dna-damage-responses
#4
Tanggang Deng, Guobei Yan, Xin Song, Lin Xie, Yu Zhou, Jianglin Li, Xiaoxiao Hu, Zhen Li, Jun Hu, Yibin Zhang, Hui Zhang, Yang Sun, Peifu Feng, Dong Wei, Bin Hu, Jing Liu, Weihong Tan, Mao Ye
p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 ubiquitin ligase complexes is the major regulatory mechanism of p21, which induces p21 degradation. However, it is unclear whether ubiquitylated p21 can be recycled. In this study, we report USP11 as a deubiquitylase of p21. In the nucleus, USP11 binds to p21, catalyzes the removal of polyubiquitin chains conjugated onto p21, and stabilizes p21 protein...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29658325/fabrication-of-a-drug-delivery-system-that-enhances-antifungal-drug-corneal-penetration
#5
Jingguo Li, Zhanrong Li, Zhen Liang, Lei Han, Huayang Feng, Siyu He, Junjie Zhang
Fungal keratitis (FK) remains a severe eye disease, and effective therapies are limited by drug shortages and critical ocular barriers. Despite the high antifungal potency and broad spectrum of econazole, its strong irritant and insolubility in water hinder its ocular application. We designed and fabricated a new drug delivery system based on a polymeric vector for the ocular antifungal application of econazole. This novel system integrates the advantages of its constituent units and exhibits superior comprehensive performance...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29618772/phosphorous-fertilization-alleviates-drought-effects-on-alnus-cremastogyne-by-regulating-its-antioxidant-and-osmotic-potential
#6
Akash Tariq, Kaiwen Pan, Olusanya Abiodun Olatunji, Corina Graciano, Zilong Li, Feng Sun, Lin Zhang, Xiaogang Wu, Wenkai Chen, Dagang Song, Dan Huang, Tan Xue, Aiping Zhang
Alnus cremastogyne, a broad-leaved tree endemic to south-western China, has both commercial and restoration importance. However, little is known of its morphological, physiological and biochemical responses to drought and phosphorous (P) application. A randomized experimental design was used to investigate how drought affected A. cremastogyne seedlings, and the role that P applications play in these responses. Drought had significant negative effects on A. cremastogyne growth and metabolism, as revealed by reduced biomass (leaf, shoot and root), leaf area, stem diameter, plant height, photosynthetic rate, leaf relative water content, and photosynthetic pigments, and a weakened antioxidative defence mechanism and high lipid peroxidation level...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614812/20-s-protopanaxadiol-induced-apoptosis-in-mcf-7-breast-cancer-cell-line-through-the-inhibition-of-pi3k-akt-mtor-signaling-pathway
#7
Hong Zhang, Hua-Li Xu, Yu-Chen Wang, Ze-Yuan Lu, Xiao-Feng Yu, Da-Yun Sui
20(S)-Protopanaxadiol (PPD) is one of the major active metabolites of ginseng. It has been reported that 20(S)-PPD shows a broad spectrum of antitumor effects. Our research study aims were to investigate whether apoptosis of human breast cancer MCF-7 cells could be induced by 20(S)-PPD by targeting the Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway in vitro and in vivo. Cell cycle analysis was performed by Propidium Iodide (PI) staining. To overexpress and knock down the expression of mTOR, pcDNA3...
April 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29611431/chromosome-identification-in-cucumis-anguria-revealed-by-cross-species-single-copy-gene-fish
#8
Ziang Li, Yunfei Bi, Xing Wang, Yun-Zhu Wang, Shu-Qiong Yang, Zhentao Zhang, Jin-Feng Chen, Qun-Feng Lou
Cucumis anguria is a potential genetic resource for improving Cucumis crops due to its broad-spectrum resistance. Few cytogenetic studies on C. anguria have been reported because of its small metaphase chromosomes and the scarcity of distinguished chromosomal landmarks. In this study, fourteen single copy genes from cucumber and rDNAs were used as probes for FISH to identify individual chromosomes of C. anguria. The distinctive signal distribution patterns of the probes allowed us to distinguish each chromosome of C...
April 3, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29595673/implants-for-orthodontic-anchorage-an-overview
#9
Xiaowen Zheng, Yannan Sun, Yimei Zhang, Ting Cai, Feng Sun, Jiuxiang Lin
Implantanchorage continues to receive much attention as an important orthodontic anchorage. Since the development of orthodontic implants, the scope of applications has continued to increase. Although multiple reviews detailing implants have been published, no comprehensive evaluations have been performed. Thus, the purpose of this study was to comprehensively evaluate the effects of implants based on data published in review articles.An electronic search of the Cochrane Library, Medline, Embase, Ebsco and Sicencedirect for reviews with "orthodontic" and "systematic review or meta analysis" in the title, abstract, keywords, or full text was performed...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29589899/broadband-and-lightweight-microwave-absorber-constructed-by-in-situ-growth-of-hierarchical-cofe-2-o-4-rgo-porous-nanocomposites
#10
Yang Liu, Zhuo Chen, Yang Zhang, Rui Feng, Xiao Chen, Chuanxi Xiong, Lijie Dong
Broadband and lightweight microwave absorber has attracted soaring research interest because of the increasing demand for electronic reliability and defense security. Lightweight ferrites/graphene porous composites with abundant interfaces are potential high-performance absorbers owing to their balanced attenuation ability and impedance matching. Herein, we synthesized hierarchical CoFe2O4/reduced graphene oxide (CFO/rGO) nanocomposites with a porous structure via an in-situ solvothermal method. The electromagnetic parameters of CFO/rGO nanocomposites can be well adjusted by modulating the weight fraction of rGO...
March 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29543242/mid-ir-broadband-supercontinuum-generation-from-a-suspended-silicon-waveguide
#11
Rai Kou, Taiki Hatakeyama, Jason Horng, Ji-Hun Kang, Yuan Wang, Xiang Zhang, Feng Wang
Mid-infrared light provides numerous unexpected opportunities in scientific discoveries because this wavelength region covers the fingerprints of various molecular vibrational resonances. However, the light generation efficiency and bandwidth have been a long-standing bottleneck which has limited the development so far. Moreover, the light source that can be integrated with other components such as wavelength filters, detectors, and electronics, will be the key factor toward the future practical applications...
March 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29521286/neuropsychological-profile-related-with-executive-function-of-chinese-preschoolers-with-attention-deficit-hyperactivity-disorder-neuropsychological-measures-and-behavior-rating-scale-of-executive-function-preschool-version
#12
Hui-Feng Zhang, Lan Shuai, Jin-Song Zhang, Yu-Feng Wang, Teng-Fei Lu, Xin Tan, Jing-Xue Pan, Li-Xiao Shen
Background: Previous studies have found that schoolchildren with attention-deficit/hyperactivity disorder (ADHD) showed difficulties in neuropsychological function. This study aimed to assess neuropsychological function in Chinese preschoolers with ADHD using broad neuropsychological measures and rating scales and to test whether the pattern and severity of neuropsychological weakness differed among ADHD presentations in preschool children. Methods: The 226 preschoolers (163 with ADHD and 63 controls) with the age of 4-5 years were included and assessed using the Behavior Rating Scale of Executive Function-Preschool Version (BRIEF-P) and a series of tests to investigate neuropsychological function...
March 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29520839/directed-assembly-of-hybrid-nanomaterials-and-nanocomposites
#13
REVIEW
Shanju Zhang, Candice I Pelligra, Xunda Feng, Chinedum O Osuji
Hybrid nanomaterials are molecular or colloidal-level combinations of organic and inorganic materials, or otherwise strongly dissimilar materials. They are often, though not exclusively, anisotropic in shape. A canonical example is an inorganic nanorod or nanosheet sheathed in, or decorated by, a polymeric or other organic material, where both the inorganic and organic components are important for the properties of the system. Hybrid nanomaterials and nanocomposites have generated strong interest for a broad range of applications due to their functional properties...
March 9, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29514906/a-dna-vaccine-expressing-consensus-hemagglutinin-esterase-fusion-protein-protected-guinea-pigs-from-infection-by-two-lineages-of-influenza-d-virus
#14
Yanmin Wan, Guobin Kang, Chithra Sreenivasan, Lance Daharsh, Junfeng Zhang, Wenjin Fan, Dan Wang, Hideaki Moriyama, Feng Li, Qingsheng Li
Two lineages of Influenza D virus (IDV) have been found to infect cattle and promote bovine respiratory disease complex (BRDC), one of the most commonly diagnosed causes of morbidity and mortality within the cattle industry. Furthermore, IDV can infect other economically important domestic livestock including pigs and has the potential to infect humans, which necessitates the need for an efficacious vaccine. In this study, we designed a DNA vaccine expressing consensus hemagglutinin-esterase-fusion (HEF) protein (FluD-Vax) and tested its protective efficacy against two lineages of IDV (D/OK and D/660) in guinea pigs...
March 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29498517/fragment-based-drug-discovery-of-inhibitors-of-phosphopantetheine-adenylyltransferase-from-gram-negative-bacteria
#15
Robert J Moreau, Colin K Skepper, Brent A Appleton, Anke Blechschmidt, Carl J Balibar, Bret M Benton, Joseph E Drumm, Brian Y Feng, Mei Geng, Cindy Li, Mika K Lindvall, Andreas Lingel, Yipin Lu, Mulugeta Mamo, Wosenu Mergo, Valery Polyakov, Thomas M Smith, Kenneth Takeoka, Kyoko Uehara, Lisha Wang, Jun-Rong Wei, Andrew H Weiss, Lili Xie, Wenjian Xu, Qiong Zhang, Javier de Vicente
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria is a major challenge with fundamental importance to our global healthcare system. Part of our broad program at Novartis to address this urgent, unmet need includes the search for new agents that inhibit novel bacterial targets. Here we report the discovery and hit-to-lead optimization of new inhibitors of phosphopantetheine adenylyltransferase (PPAT) from Gram-negative bacteria...
March 2, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29498389/highly-stretchable-strain-sensors-with-reduced-graphene-oxide-sensing-liquids-for-wearable-electronics
#16
Minxuan Xu, Junjie Qi, Feng Li, Yue Zhang
Strain sensors with high sensitivity, broad sensing ranges and excellent durable stability are highly desirable due to their promising potential in electronic skins and human-friendly wearable interactive systems. Herein, we report a high-performance strain sensor based on rGO (reduced graphene oxide)/DI (deionized water) sensing elements. The strain sensors were fabricated by using Ecoflex rubber filled with rGO/DI conductive liquids via template methods, making the process simple, low-cost and scalable. The as-assembled strain sensors can be used to reflect both stretching and compressing with high sensitivity (a maximum gauge factor of 31...
March 2, 2018: Nanoscale
https://www.readbyqxmd.com/read/29489327/near-infrared-light-sensitive-ultraviolet-blue-nanophotoswitch-for-imaging-guided-off-on-therapy
#17
Jing Zuo, Langping Tu, Qiqing Li, Yansong Feng, Ivo Que, Youlin Zhang, Xiaomin Liu, Bin Xue, Luis J Cruz, Yulei Chang, Hong Zhang, Xianggui Kong
Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts -photobleaching. However, current PUCNPs follow solely Yb3+ /Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV-blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs-NaErF4 @NaYF4 @NaYbF4 :0...
March 2, 2018: ACS Nano
https://www.readbyqxmd.com/read/29469816/white-light-emitting-device-based-on-single-phase-cds-quantum-dots
#18
Feng Li, Chao Nie, Lai You, Xiao Jin, Qin Zhang, Yuancheng Qin, Feng Zhao, Yinglin Song, Zhongping Chen, Qinghua Li
White light emitting diodes (WLEDs) based on quantum dots (QDs) are emerging as robust candidates for white light source, however they are suffering from the problem of energy loss resulted from the re-absorption and self-absorption among the employed QDs of different peak wavelengths. It still remains a challenging task to construct WLEDs based on single-phase QD emitters. Here, CdS QDs with short synthesis time is introduced to the fabrication of WLEDs. With short synthesis time, on one hand, CdS QD of small diameter with blue emission can be obtained...
February 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29462072/anterior-to-dorsal-root-entry-zone-myelotomy-adrezotomy-a-new-surgical-approach-for-the-treatment-of-ventrolateral-deep-intramedullary-spinal-cord-cavernous-malformations
#19
Jian Ren, Chuan He, Tao Hong, Xiaoyu Li, Yongjie Ma, Jiaxing Yu, Feng Ling, Hongqi Zhang
STUDY DESIGN: A retrospective review of prospectively collected data. OBJECTIVE: To confirm the feasibility of using anterior to dorsal root entry zone myelotomy (ADREZotomy), a new surgical approach, for the treatment of ventrolateral deep ISCCMs. SUMMARY OF BACKGROUND DATA: Surgical removal of ventrolateral deep intramedullary spinal cord cavernous malformations (ISCCMs) is highly risky and remains problematic. METHODS: The authors performed a retrospective study exploring the surgical removal of ventrolateral intrinsic ISCCMs using ADREZotomy in 10 patients...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29457442/-development-and-application-of-artificial-vertebral-body
#20
REVIEW
Jian-Tao Liu, Feng Zhang, Zheng-Chao Gao, Bin-Bin Niu, Yu-Huan Li, Xi-Jing He
Artificial vertebral body has achieved good results in treating spinal tumors, tuberculosis, fracture and other diseases. Currently, artificial vertebral body with variety of kinds and pros and cons, is generally divided into two types: fusion type and movable type. The former according to whether the height could be adjusted and strength of self-stability is divided into three types: support-fixed type, adjust-fixed type and self-fixed type. Whether the height of self-fixed type could be adjusted is dependent on structure of collar thread rotation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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