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https://www.readbyqxmd.com/read/29220792/4-quinolone-derivatives-and-their-activities-against-gram-positive-pathogens
#1
Gui-Fu Zhang, Shu Zhang, Baofeng Pan, Xiaofeng Liu, Lian-Shun Feng
Gram-positive bacteria are responsible for a broad range of infectious diseases, and the emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA and MRSE has caused great concern throughout the world. 4-Quinolones which are exemplified by fluoroquinolones are mainstays of chemotherapy against various bacterial infections including Gram-positive pathogen infections, and their value and role in the treatment of bacterial infections continues to expand. However, the resistance of Gram-positive organisms to 4-quinolones develops rapidly and spreads widely, making them more and more ineffective...
November 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29201192/daidzein-ameliorates-spinal-cord-ischemia-reperfusion-injury-induced-neurological-function-deficits-in-sprague-dawley-rats-through-pi3k-akt-signaling-pathway
#2
Fan Zhang, Neng Ru, Zheng-Hui Shang, Jian-Feng Chen, Chao Yan, Yun Li, Jie Liang
Daidzein (DZ) has a broad spectrum of biological activities, including antioxidant, anti-inflammatory and anticancer as well as cardio- and hepatoprotective properties. The present study was designed to elucidate the in-depth mechanism underlying the neuroprotective efficacy of DZ against spinal cord ischemic/reperfusion injury (SCII) in a rat model by comparison with the standard neuroprotective agent methylprednisolone (MP). A total of 48 rats were divided into four groups of twelve rats in each (n=12). In sham-operated group (Control) group, rats received only saline (Fogarty catheter was inserted without balloon inflation), whereas rats in the SCII induction group (SCII) were subjected to SCII insult by insertion of a Fogarty balloon catheter, which was inflated in the descending thoracic aorta to cause an occlusion...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29186218/post-targeting-strategy-for-ready-to-use-targeted-nanodelivery-post-cargo-loading
#3
J Y Zhu, J J Hu, M K Zhang, W Y Yu, D W Zheng, X Q Wang, J Feng, X Z Zhang
Based on boronate formation, this study reports a post-targeting methodology capable of readily installing versatile targeting modules onto a cargo-loaded nanoplatform in aqueous mediums. This permits the targeted nanodelivery of broad-spectrum therapeutics (drug/gene) in a ready-to-use manner while overcoming the PEGylation-dilemma that frequently occurs in conventional targeting approaches.
November 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/29170366/initiation-of-hiv-neutralizing-b-cell-lineages-with-sequential-envelope-immunizations
#4
Wilton B Williams, Jinsong Zhang, Chuancang Jiang, Nathan I Nicely, Daniela Fera, Kan Luo, M Anthony Moody, Hua-Xin Liao, S Munir Alam, Thomas B Kepler, Akshaya Ramesh, Kevin Wiehe, James A Holland, Todd Bradley, Nathan Vandergrift, Kevin O Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori, David C Montefiori, Mark Louder, Amanda Eaton, Sampa Santra, Richard Scearce, Laura Sutherland, Amanda Newman, Hilary Bouton-Verville, Cindy Bowman, Howard Bomze, Feng Gao, Dawn J Marshall, John F Whitesides, Xiaoyan Nie, Garnett Kelsoe, Steven G Reed, Christopher B Fox, Kim Clary, Marguerite Koutsoukos, David Franco, John R Mascola, Stephen C Harrison, Barton F Haynes, Laurent Verkoczy
A strategy for HIV-1 vaccine development is to define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and to recreate those events by vaccination. Here, we report host tolerance mechanisms that limit the development of CD4-binding site (CD4bs), HCDR3-binder bnAbs via sequential HIV-1 Env vaccination. Vaccine-induced macaque CD4bs antibodies neutralize 7% of HIV-1 strains, recognize open Env trimers, and accumulate relatively modest somatic mutations. In naive CD4bs, unmutated common ancestor knock-in mice Env+B cell clones develop anergy and partial deletion at the transitional to mature B cell stage, but become Env- upon receptor editing...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29166853/proteomic-insight-into-fruit-set-of-cucumber-cucumis-sativus-l-suggests-the-cues-of-hormone-independent-parthenocarpy
#5
Ji Li, Jian Xu, Qin-Wei Guo, Zhe Wu, Ting Zhang, Kai-Jing Zhang, Chun-Yan Cheng, Pin-Yu Zhu, Qun-Feng Lou, Jin-Feng Chen
BACKGROUND: Parthenocarpy is an excellent agronomic trait that enables crops to set fruit in the absence of pollination and fertilization, and therefore to produce seedless fruit. Although parthenocarpy is widely recognized as a hormone-dependent process, hormone-insensitive parthenocarpy can also be observed in cucumber; however, its mechanism is poorly understood. To improve the global understanding of parthenocarpy and address the hormone-insensitive parthenocarpy shown in cucumber, we conducted a physiological and proteomic analysis of differently developed fruits...
November 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29162543/identification-expression-analysis-and-antibacterial-activity-of-nk-lysin-from-common-carp-cyprinus-carpio
#6
Gai Ling Wang, Ming Cheng Wang, Ying Li Liu, Qian Zhang, Chuan Feng Li, Pan Ting Liu, En Zhong Li, Pin Nie, Hai Xia Xie
Natural killer lysin (NK-lysin), produced by cytotoxic T lymphocytes and natural killer cells, is a cationic antimicrobial peptide that has a broad antimicrobial spectrum, including bacteria, viruses, and parasites. Nevertheless, the implication of NK-lysin in the protection against bacterial infection is not aware in common carp. In this study, six different NK-lysin genes (nkl1, nkl2, nkl3, nkl4, nkl5 and nkl6) were identified in the common carp genome. Each of the mature peptides of common carp NK-lysin has six well-conserved cysteine residues, and shares a Saposin B domain, characteristic of saposin-like protein (SALIP) family...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29158787/high-expression-of-fam83b-predicts-poor-prognosis-in-patients-with-pancreatic-ductal-adenocarcinoma-and-correlates-with-cell-cycle-and-cell-proliferation
#7
Chao-Qin Shen, Ting-Ting Yan, Wei Liu, Xiao-Qiang Zhu, Xiang-Long Tian, Xue-Liang Fu, Rong Hua, Jun-Feng Zhang, Yan-Miao Huo, De-Jun Liu, Jian-Yu Yang, Yong-Wei Sun, Jing-Yuan Fang, Hao-Yan Chen, Jie Hong
FAM83B (family with sequence similarity 83, member B) seems to emerge as a new class of players involved in the development of a variety of malignant tumors. Yet the molecular mechanisms are not well understood. The present study is intended to investigate the expression and function of FAM83B in pancreatic ductal adenocarcinoma (PDAC). In this study, we found that the expression of FAM83B was significantly increased both in PDAC cell lines and PDAC tumor tissues. FAM83B expression was positively related with advanced clinical stage and poor vital status...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29154475/identification-and-analysis-of-a-key-long-non-coding-rnas-lncrnas-associated-module-reveal-functional-lncrnas-in-cardiac-hypertrophy
#8
Jian Zhang, Chenchen Feng, Chao Song, Bo Ai, Xuefeng Bai, Yuejuan Liu, Xuecang Li, Jianmei Zhao, Shengshu Shi, Xin Chen, Xiaojie Su, Chunquan Li
Cardiac hypertrophy (CH) is a common disease that originates from long-term heart pressure overload and finally leads to heart failure. Recently, long non-coding RNAs (lncRNAs) have attracted attention because they have broad and crucial functions in regulating complex biological processes. Some studies had found that lncRNAs play vital roles in complex cardiovascular diseases. However, the function and mechanism of lncRNAs in CH have not been elucidated. In our study, to investigate the potential roles of lncRNAs in CH, the Cardiac Hypertrophy-associated LncRNAs-Protein coding genes Network (CHLPN) was constructed by integrating gene microarray re-annotation and subpathway enrichment analyses...
November 20, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29127408/statistical-analysis-for-collision-free-boson-sampling
#9
He-Liang Huang, Han-Sen Zhong, Tan Li, Feng-Guang Li, Xiang-Qun Fu, Shuo Zhang, Xiang Wang, Wan-Su Bao
Boson sampling is strongly believed to be intractable for classical computers but solvable with photons in linear optics, which raises widespread concern as a rapid way to demonstrate the quantum supremacy. However, due to its solution is mathematically unverifiable, how to certify the experimental results becomes a major difficulty in the boson sampling experiment. Here, we develop a statistical analysis scheme to experimentally certify the collision-free boson sampling. Numerical simulations are performed to show the feasibility and practicability of our scheme, and the effects of realistic experimental conditions are also considered, demonstrating that our proposed scheme is experimentally friendly...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29111475/a-total-evidence-phylogeny-of-the-lady-fern-genus-athyrium-roth-athyriaceae-with-a-new-infrageneric-classification
#10
Ran Wei, Atsushi Ebihara, Yan-Mei Zhu, Cun-Feng Zhao, Sabine Hennequin, Xian-Chun Zhang
The lady fern genus Athyrium represents one of the most diversified lineages in Athyriaceae with about 160-220 known species, and is notorious for its taxonomic difficulty. Despite progress in recent phylogenetic studies involving this genus, it still lacks a modern systematic and taxonomic update using integrative analyses of molecular and morphological evidence based on a broad species sampling. Here, we present, to our knowledge, the most comprehensive phylogenetic analysis of the genus to date based on a total-evidence approach, covering all formerly accepted segregates within the athyrioid ferns...
October 27, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29091883/lipophagy-and-liver-disease-new-perspectives-to-better-understanding-and-therapy
#11
REVIEW
Zili Zhang, Zhen Yao, Yifan Chen, Lei Qian, Shuoyi Jiang, Jingyi Zhou, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. The recent finding that LDs can be selectively degraded by the lysosomal pathway of autophagy through a process termed lipophagy has opened up a new understanding of how lipid metabolism regulates cellular physiology and pathophysiology. Many new functions for autophagic lipid metabolism have now been defined in various diseases including liver disease...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29091396/donor-acceptor-conjugated-macrocycles-synthesis-and-host-guest-coassembly-with-fullerene-toward-photovoltaic-application
#12
Si-Qi Zhang, Zhen-Yu Liu, Wei-Fei Fu, Feng Liu, Chuan-Ming Wang, Chun-Qi Sheng, Yi-Fei Wang, Ke Deng, Qing-Dao Zeng, Li-Jin Shu, Jun-Hua Wan, Hong-Zheng Chen, Thomas P Russell
Electron-rich (donor) and electron-deficient (acceptor) units to construct donor-acceptor (D-A) conjugated macrocycles were investigated to elucidate their interactions with electron-deficient fullerene. Triphenylamine and 4,7-bisthienyl-2,1,3-benzothiadiazole were alternately linked through acetylene, as the donor and acceptor units, respectively, for pentagonal 3B2A and hexagonal 4B2A macrocycles. As detected by scanning tunneling microscopy, both D-A macrocycles were found to form an interesting concentration-controlled nanoporous monolayer on highly oriented pyrolytic graphite, which could effectively capture fullerene...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29078783/a-novel-polyomavirus-from-the-nasal-cavity-of-a-giant-panda-ailuropoda-melanoleuca
#13
Dunwu Qi, Tongling Shan, Zhijian Liu, Xutao Deng, Zhihe Zhang, Wenlei Bi, Jacob Robert Owens, Feifei Feng, Lisong Zheng, Feng Huang, Eric Delwart, Rong Hou, Wen Zhang
BACKGROUND: Polyomaviruses infect a wide variety of mammalian and avian hosts with a broad spectrum of outcomes including asymptomatic infection, acute systemic disease, and tumor induction. METHODS: Viral metagenomics and general PCR methods were used to detected viral nucleic acid in the samples from a diseased and healthy giant pandas. RESULTS: A novel polyomavirus, the giant panda polyomavirus 1 (GPPyV1) from the nasal cavity of a dead giant panda (Ailuropoda melanoleuca) was characterized...
October 27, 2017: Virology Journal
https://www.readbyqxmd.com/read/29070703/rna-editing-with-crispr-cas13
#14
David B T Cox, Jonathan S Gootenberg, Omar O Abudayyeh, Brian Franklin, Max J Kellner, Julia Joung, Feng Zhang
Nucleic acid editing holds promise for treating genetic disease, particularly at the RNA level, where disease-relevant sequences can be rescued to yield functional protein products. Type VI CRISPR-Cas systems contain the programmable single-effector RNA-guided ribonuclease Cas13. We profiled type VI systems in order to engineer a Cas13 ortholog capable of robust knockdown and demonstrated RNA editing by using catalytically inactive Cas13 (dCas13) to direct adenosine-to-inosine deaminase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts in mammalian cells...
November 24, 2017: Science
https://www.readbyqxmd.com/read/29062065/a-chloroquine-induced-macrophage-preconditioning-strategy-for-improved-nanodelivery
#15
Joy Wolfram, Sara Nizzero, Haoran Liu, Feng Li, Guodong Zhang, Zheng Li, Haifa Shen, Elvin Blanco, Mauro Ferrari
Site-specific localization is critical for improving the therapeutic efficacy and safety of drugs. Nanoparticles have emerged as promising tools for localized drug delivery. However, over 90% of systemically injected nanocarriers typically accumulate in the liver and spleen due to resident macrophages that form the mononuclear phagocyte system. In this study, the clinically approved antimalarial agent chloroquine was shown to reduce nanoparticle uptake in macrophages by suppressing endocytosis. Pretreatment of mice with a clinically relevant dose of chloroquine substantially decreased the accumulation of liposomes and silicon particles in the mononuclear phagocyte system and improved tumoritropic and organotropic delivery...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050217/triterpenoids-from-aglaia-abbreviata-exert-cytotoxicity-and-multidrug-resistant-reversal-effect-in-mcf-7-adm-cells-via-reactive-oxygen-species-induction-and-p-glycoprotein-inhibition
#16
Juan Cen, Beibei Zheng, Rubing Bai, Li Zhang, Feng Zhang, Xia Zhang
Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. The drug efflux transporter P-glycoprotein (P-gp) and the intracellular antioxidant systems, involving Glutathione S-Transferase π, Glutathione and heme oxygenase-1, were also inhibited via the ROS-depressed Akt/NF-E2-related factor 2 pathway...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045957/-clinical-characteristics-of-neonatal-fungal-sepsis-in-neonatal-intensive-care-unit
#17
X Zhang, X F Ru, Y Wang, X Li, T Sang, Q Feng
OBJECTIVE: To study the characteristics of neonatal fungal sepsis and the difference between bacterial sepsis and fungal sepsis. To improve the understanding of neonatal fungal sepsis. METHODS: Clinical data of neonatal fungal sepsis in neonatal intensive care unit (NICU) were collected from 2011 to 2016 in Peking University first Hospital. The clinical characteristics were analyzed retrospectively. The difference between neonatal fungal sepsis and bacterial sepsis was also analyzed...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29042988/toll-like-receptor-2-and-dectin-1-function-as-promising-biomarker-for-aspergillus-fumigatus-infection
#18
Peng-Peng Zhang, Xiao-Feng Xin, Xiao-Yong Xu, Li-Ping Fang, Jie Wu, Yi Shi
In recent years, along with the wide application of organ transplantation and immunosuppressive agents, as well as the abuse of broad spectrum antibiotics, the incidence of invasive fungal infections has been increasing gradually. The present study aimed to identify novel biomarkers in cells infected with Aspergillus fumigatus. Human umbilical vein endothelial cells (HUVECs) were infected with Aspergillus fumigatus and then harvested at different time-points (0, 1, 2, 4 and 6 h). The expression Toll-like receptor 2 (TLR2) and dectin-1 expression were examined using flow cytometry and western blotting, and fluorescence-based microscopy was used to evaluate their distribution...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29038502/three-dimensional-layered-water-soluble-cellulose-acetate-polyacrylamide-composites-with-ultrahigh-ductility-and-stretchability
#19
Jinhui Pang, Miao Wu, Xin Liu, Bo Wang, Jun Yang, Feng Xu, Mingguo Ma, Xueming Zhang
Water-soluble cellulose acetate (WSCA), one of the most important cellulose derivatives, possesses biocompatibility, biodegradability and broad chemical modifying capacities. In this work, highly polymerized WSCA was firstly synthesized and used as cross-linker to fabricate highly ductile, tough and resilient WSCA/polyacrylamide (PAM) composite hydrogels. The results showed that the WSCA/PAM nanocomposite hydrogels exhibited extraordinary toughness and ductility with a tensile strength of 297 kPa and elongation at break of about 4020%...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038275/in-vivo-bioluminescent-monitoring-of-therapeutic-efficacy-and-pharmacodynamic-target-assessment-of-antofloxacin-against-escherichia-coli-in-a-neutropenic-murine-thigh-infection-model
#20
Yu-Feng Zhou, Meng-Ting Tao, Yu-Zhang He, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao
Antimicrobial resistance among uropathogens has increased infection-related morbidity and mortality. Antofloxacin is a novel fluoroquinolone with broad-spectrum antibacterial activity against urinary Gram-negative bacilli such as Escherichia coli This study monitored the in vivo efficacy of antofloxacin using bioluminescence imaging and determined pharmacokinetic/pharmacodynamic (PK/PD) targets against E. coli isolates in a neutropenic murine thigh infection model. The PK properties were performed after subcutaneous antofloxacin administration of 2...
October 16, 2017: Antimicrobial Agents and Chemotherapy
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