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https://www.readbyqxmd.com/read/28319297/tandem-coupling-of-azide-with-isonitrile-and-boronic-acid-facile-access-to-functionalized-amidines
#1
Zhen Zhang, Baoliang Huang, Guanyu Qiao, Liu Zhu, Fan Xiao, Feng Chen, Bin Fu, Zhenhua Zhang
Amidine is a notable nitrogen-containing structural motif found in bioactive natural products and pharmaceuticals. Herein, a novel rhodium(I)-catalyzed tandem reaction of readily accessible azides with isonitriles and boronic acids via a carbodiimide intermediate is achieved. This protocol offers an alternative approach toward N-sulfonyl-, N-acyl-, and N- phosphoryl-functionalized, as well as general N-aryl and N-alkyl amidines with broad substrate scope. In addition, functionalized guanidines can also been synthesized when amines are used instead...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28306312/dirac-fermions-in-borophene
#2
Baojie Feng, Osamu Sugino, Ro-Ya Liu, Jin Zhang, Ryu Yukawa, Mitsuaki Kawamura, Takushi Iimori, Howon Kim, Yukio Hasegawa, Hui Li, Lan Chen, Kehui Wu, Hiroshi Kumigashira, Fumio Komori, Tai-Chang Chiang, Sheng Meng, Iwao Matsuda
Honeycomb structures of group IV elements can host massless Dirac fermions with nontrivial Berry phases. Their potential for electronic applications has attracted great interest and spurred a broad search for new Dirac materials especially in monolayer structures. We present a detailed investigation of the β_{12} sheet, which is a borophene structure that can form spontaneously on a Ag(111) surface. Our tight-binding analysis revealed that the lattice of the β_{12} sheet could be decomposed into two triangular sublattices in a way similar to that for a honeycomb lattice, thereby hosting Dirac cones...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28304152/reprogramming-of-histone-methylation-controls-the-differentiation-of-monocytes-into-macrophages
#3
Qi-Fan Zheng, Hui-Min Wang, Zhan-Feng Wang, Jin-Yang Liu, Qi Zhang, Li Zhang, Yuan-Hua Lu, Han You, Guang-Hui Jin
Subset heterogeneity of the mononuclear phagocyte system (MPS) is controlled by defined transcriptional networks and programs; however, the dynamic establishment of programs that control broad, orchestrated expression of transcription factors (TFs) during the progression of monocyte-into-phagocyte (MP) differentiation remains largely unexplored. By using chromatin immunoprecipitation assays, we show the extensive trimethylation of histone H3 lysine 4 (H3K4me3) as well as histone H3 lysine 27 (H3K27me3) occupancy with broad footprints at the promoters of MP differentiation-related TFs, such as HOXA and FOXO genes, KLF4, IRF8 and others...
March 17, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28304070/manganese-iii-acetate-catalyzed-oxidative-amination-of-benzylic-c-sp-3-h-bonds-with-nitriles
#4
Yaxing Zhang, Jianyu Dong, Lixin Liu, Long Liu, Yongbo Zhou, Shuang-Feng Yin
Mn-Catalyzed oxidative amination of benzylic C(sp(3))-H bonds with nitriles is disclosed, which enables the synthesis of a broad range of secondary amides in moderate to excellent yields under mild conditions. The interaction between Mn(iii) and DDQ facilitates the oxidation and makes it highly efficient and selective.
March 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28299865/novel-short-antimicrobial-peptide-isolated-from-xenopus-laevis-skin
#5
Yu Zhang, Songcai Liu, Siming Li, Yunyun Cheng, Linyan Nie, Gang Wang, Chen Lv, Wenzhen Wei, Cheng Cheng, Feng Hou, Linlin Hao
A rich source of bioactive peptides, including a large number of antimicrobial peptides, has been found in amphibian skin. In this study, a novel short antimicrobial peptide was purified from Xenopus laevis skin and characterised through reversed-phase high-performance liquid chromatography, Edman degradation and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. The peptide was composed of six amino acids with a sequence of DEDLDE and thus named X. laevis antibacterial peptide-P2 (XLAsp-P2)...
March 16, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28298420/staged-induction-of-hiv-1-glycan-dependent-broadly-neutralizing-antibodies
#6
Mattia Bonsignori, Edward F Kreider, Daniela Fera, R Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S Munir Alam, Baptiste Aussedat, William E Walkowicz, Kwan-Ki Hwang, Kevin O Saunders, Ruijun Zhang, Morgan A Gladden, Anthony Monroe, Amit Kumar, Shi-Mao Xia, Melissa Cooper, Mark K Louder, Krisha McKee, Robert T Bailer, Brendan W Pier, Claudia A Jette, Garnett Kelsoe, Wilton B Williams, Lynn Morris, John Kappes, Kshitij Wagh, Gift Kamanga, Myron S Cohen, Peter T Hraber, David C Montefiori, Ashley Trama, Hua-Xin Liao, Thomas B Kepler, M Anthony Moody, Feng Gao, Samuel J Danishefsky, John R Mascola, George M Shaw, Beatrice H Hahn, Stephen C Harrison, Bette T Korber, Barton F Haynes
A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site adjacent to the third variable loop (V3) of the HIV-1 envelope protein require limited SHM, the V3-glycan epitope is an attractive vaccine target. By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, we identify key events in the ontogeny of a V3-glycan bnAb...
March 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28289407/a-novel-antimicrobial-endolysin-lyspa26-against-pseudomonas-aeruginosa
#7
Mingquan Guo, Chunyan Feng, Jie Ren, Xuran Zhuang, Yan Zhang, Yongzhang Zhu, Ke Dong, Ping He, Xiaokui Guo, Jinhong Qin
The global increase in multidrug resistant (MDR) bacteria has led to phage therapy being refocused upon. A novel endolysin, LysPA26, containing a lysozyme-like domain, was screened against Pseudomonas aeruginosa in this study. It had activity against MDR P. aeruginosa without pretreatment with an outer-membrane permeabilizer. LysPA26 could kill up to 4 log units P. aeruginosa in 30 min. In addition, temperature and pH effect assays revealed that LysPA26 had good stability over a broad range of pH and temperatures...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28287720/discovery-of-novel-pyridone-conjugated-monosulfactams-as-potent-and-broad-spectrum-antibiotics-for-multidrug-resistant-gram-negative-infections
#8
Liang Tan, Yunliang Tao, Ting Wang, Feng Zou, Shuhua Zhang, Qunhuan Kou, Ao Niu, Qian Chen, Wenjing Chu, Xiaoyan Chen, Haidong Wang, Yushe Yang
Conjugating a siderophore to an antibiotic is a promising strategy to overcome the permeability-mediated resistance of Gram-negative pathogens. Based on the structure of BAL30072, novel pyridone-conjugated monosulfactams incorporating diverse substituents into the methylene linker between the 1,3-dihydroxypyridin-4(1H)-one and the aminothiazole oxime were designed and synthesized. Structure-activity relationship studies revealed that a variety of substituents were tolerated, with isopropyl (compound 12c) and methylthiomethyl (compound 16a) showing the best efficacy against multidrug-resistant (MDR) Gram-negative pathogens...
March 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28279345/generation-of-a-live-attenuated-influenza-vaccine-that-elicits-broad-protection-in-mice-and-ferrets
#9
Lulan Wang, Su-Yang Liu, Hsiang-Wen Chen, Juan Xu, Maxime Chapon, Tao Zhang, Fan Zhou, Yao E Wang, Natalie Quanquin, Guiqin Wang, Xiaoli Tian, Zhanlong He, Longding Liu, Wenhai Yu, David Jesse Sanchez, Yuying Liang, Taijiao Jiang, Robert Modlin, Barry R Bloom, Qihan Li, Jane C Deng, Paul Zhou, F Xiao-Feng Qin, Genhong Cheng
New influenza vaccines that provide effective and broad protection are desperately needed. Live attenuated viruses are attractive vaccine candidates because they can elicit both humoral and cellular immune responses. However, recent formulations of live attenuated influenza vaccines (LAIVs) have not been protective. We combined high-coverage transposon mutagenesis of influenza virus with a rapid high-throughput screening for attenuation to generate W7-791, a live attenuated mutant virus strain. W7-791 produced only a transient asymptomatic infection in adult and neonatal mice even at doses 100-fold higher than the LD50 of the parent strain...
March 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28263880/tc38-a-teleost-tfpi-2-peptide-that-kills-bacteria-via-penetration-of-the-cell-membrane-and-interaction-with-nucleic-acids
#10
Min Zhang, Bin Yue, Ai-Hua Zhang, Guang-Hua Wang, Yong Liu, Shun Zhou, Shun-Feng Cheng, Ning-Qiu Li
Tissue factor pathway inhibitor 2 (TFPI-2) is an analog of TFPI-1 and a potent endogenous inhibitor of tissue factor (TF)-mediated blood coagulation. Recent reports have proven that the C-terminal of TFPI-2 peptides in humans and several other vertebrates possesses antibacterial activity against Gram-positive and Gram-negative bacteria. In our previous study, we reported that the TFPI-2 peptide, TC38 in tongue sole (Cynoglossus semilaevis) was active against Micrococcus luteus. In this study, we further examine the antimicrobial spectrum, mechanism of action, and function of TC38 in tongue sole...
March 2, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28252286/phosphine-free-synthesis-of-metal-chalcogenide-quantum-dots-by-directly-dissolving-chalcogen-dioxides-in-alkylthiol-as-the-precursor
#11
Dong Yao, Wei Xin, Zhaoyu Liu, Ze Wang, Jianyou Feng, Chunwei Dong, Yi Liu, Bai Yang, Hao Zhang
Semiconductor quantum dots (QDs) are competitive emitting materials in developing new-generation light-emitting diodes (LEDs) with high color rendering and broad color gamut. However, the use of highly toxic alkylphosphines cannot be fully avoided in the synthesis of metal selenide and telluride QDs because they are requisite reducing agents and solvents for preparing chalcogen precursors. In this work, we demonstrate the phosphine-free preparation of selenium (Se) and tellurium (Te) precursors by directly dissolving chalcogen dioxides in the alkylthiol under the mild condition...
March 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28243801/ribavirin-attenuates-the-respiratory-immune-responses-to-influenza-viral-infection-in-mice
#12
Shang-Hui Liao, Yun Li, Yan-Ni Lai, Ni Liu, Feng-Xue Zhang, Pei-Ping Xu
Ribavirin is a broad-spectrum antiviral agent that is used against RNA and DNA viruses and has been reported to inhibit infection by influenza A and B virus in vitro and in vivo. Studies have shown that ribavirin can lower convalescent antibody titers in young children hospitalized with influenza. Here, we report that ribavirin administration in juvenile mice significantly attenuated respiratory immune responses, production of total IgA and hemagglutinin (HA)-specific secretory IgA responses on the mucosal surface...
February 27, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28242495/a-reaction-based-near-infrared-fluorescent-sensor-for-cu-2-detection-in-aqueous-buffer-and-its-application-in-living-cells-and-tissues-imaging
#13
Huatang Zhang, Ling Feng, Yin Jiang, Yin-Ting Wong, Yonghe He, Guansheng Zheng, Jun He, Yi Tan, Hongyan Sun, Derek Ho
Copper (II) is one of the most of important cofactors for numerous enzymes and has captured broad attention due to its role as a neurotransmitters for physiological and pathological functions. In this article, we present a reaction-based fluorescent sensor for Cu(2+) detection (NIR-Cu) with near-infrared excitation and emission, including probe design, structure characterization, optical property test and biological imaging application. NIR-Cu is equipped with a functional group, 2-picolinic ester, which hydrolyzes in the presence of Cu(2+) with high selectivity over completed cations...
February 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28212095/identifying-bacterial-essential-genes-based-on-a-feature-integrated-method
#14
Yan Lin, Fa-Zhan Zhang, Kai Xue, Yi-Zhou Gao, Feng-Biao Guo
Essential genes are those genes of an organism that are considered to be crucial for its survival. Identification of essential genes is therefore of great significance to advance our understanding of the principles of cellular life. We have developed a novel computational method, which can effectively predict bacterial essential genes by extracting and integrating homologous features, protein domain feature, gene intrinsic features and network topological features. By performing the principal component regression (PCR) analysis for Escherichia coli MG1655, we established a classification model with the average area under curve (AUC) value of 0...
February 15, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28202939/from-initial-nucleation-to-cassie-baxter-state-of-condensed-droplets-on-nanotextured-superhydrophobic-surfaces
#15
Cunjing Lv, Xiwen Zhang, Fenglei Niu, Feng He, Pengfei Hao
Understanding how droplet condensation happens plays an essential role for our fundamental insights of wetting behaviors in nature and numerous applications. Since there is a lack of study of the initial formation and growing processes of condensed droplets down to nano-/submicroscale, relevant underlying mechanisms remain to be explored. We report an in situ observation of vapor condensation on nano-/microtextured superhydrophobic surfaces using optical microscopy. An interesting picture of the vapor condensation, from the initial appearance of individual small droplets (≤1 μm) to a Cassie-Baxter wetting state (>30 μm), are exhibited...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28182976/ultrasensitive-electrochemical-immunosensor-for-quantitative-detection-of-scca-using-co3o4-ceo2-au-pt-nanocomposite-as-enzyme-mimetic-labels
#16
Yueyun Li, Yihe Zhang, Faying Li, Jinhui Feng, Mingdang Li, Lei Chen, Yunhui Dong
Recently early diagnosis of squamous cell carcinoma antigen (SCCA) as a tumor maker of various cancers has increasingly attracted a lot of attention with heightening of incidence rate of cancer. The SCCA with low concentration in human serum should be diluted before detecting. Thus, an immunoassay with high sensitivity is significant for early detecting SCCA. Therefore, a nonenzymatic sandwich-type electrochemical immunosensor herein was conducted to quantitative detection of squamous cell carcinoma antigen (SCCA)...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28176795/metamaterial-study-of-quasi-three-dimensional-bowtie-nanoantennas-at-visible-wavelengths
#17
Yukun Zhao, Feng Yun, Yi Huang, Shuai Wang, Lungang Feng, Yufeng Li, Maofeng Guo, Wen Ding, Ye Zhang
In this paper, a novel array of quasi-three-dimensional (quasi-3D) bowtie nanoantennas has been investigated numerically and experimentally. A low-cost and facile method has been designed and implemented to fabricate the quasi-3D bowtie nanoantennas. The fabrication processes containing laser patterning and wet etching have demonstrated the advantages of easily tuning the periodic and diameter of microhole arrays. According to the simulated results, the electric and magnetic resonances at visible wavelengths are obtained in the tips and contours of the metamaterials made of the quasi-3D bowtie nanoantennas, respectively...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164788/variations-in-the-bacterial-community-compositions-at-different-sites-in-the-tomb-of-emperor-yang-of-the-sui-dynasty
#18
Zhi Huang, Fei Zhao, Yonghui Li, Jianwei Zhang, Youzhi Feng
To fully understand the bacterial processes in tomb environments, it is necessary to investigate the details of the bacterial communities present under such oligotrophic conditions. Here, high-throughput sequencing based on partial 16S rRNA gene sequences was used to fully evaluate the bacterial communities at different sites in the tomb of Emperor Yang of the Sui Dynasty. We also aimed to identify the soil factors that were significant related to bacterial diversity and community composition. The results showed the presence of a broad taxonomic diversity that included nine major phyla...
March 2017: Microbiological Research
https://www.readbyqxmd.com/read/28158035/self-injection-locked-and-semiconductor-amplified-ultrashort-cavity-single-frequency-yb-sup-3-sup-doped-phosphate-fiber-laser-at-978-nm
#19
Zhenpeng Huang, Huaqiu Deng, Changsheng Yang, Qilai Zhao, Yuanfei Zhang, Yuning Zhang, Zhouming Feng, Zhongmin Yang, Mingying Peng, Shanhui Xu
Based on a self-injection locking scheme and the nonlinear amplification effect of a semiconductor optical amplifier, a low intensity noise amplified ultrashort cavity single-frequency fiber laser at 978 nm is demonstrated with a final output power of > 230 mW and a broad temperature range of > 15 °C for single-longitudinal-mode operation. The effective cavity length of the fiber oscillator is less than 6 mm, comprising a 3.5-mm-long highly Yb<sup>3+</sup>-doped phosphate fiber and a pair of fiber Bragg gratings...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28155195/clinical-evaluation-of-the-isothermal-amplification-assays-for-the-detection-of-four-common-respiratory-viruses-in-children-with-pneumonia
#20
Hangyu Zhou, Mengchuan Zhao, Xinna Li, Dan Zhang, Shuaifeng Zhou, Chen Chen, Zhishan Feng, Xuejun Ma
Respiratory viruses are recognized as serious causes of morbidity and mortality in lower respiratory tract infections in patients. Isothermal amplification assays are increasingly used in their detection because of their rapidity, simplicity and cost-effectiveness, when compared to traditional molecular diagnostic methods. However, systematic assessment of these assays in the clinical settings is rarely reported. MEDLINE (Pubmed) searches were done analysing subject headings and words in the abstract related to isothermal amplification assay and virus...
February 2, 2017: Archives of Virology
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