keyword
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#1
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533759/regulating-the-pore-structure-of-activated-carbon-by-pitch-for-high-performance-sodium-ion-storage
#2
JOURNAL ARTICLE
Yan-Ru Tian, Zong-Lin Yi, Fang-Yuan Su, Li-Jing Xie, Xu-Feng Zhang, Xiong-Fei Li, Jia-Yao Cheng, Jing-Peng Chen, Cheng-Meng Chen
The pore structure of carbon anodes plays a crucial role in enhancing the sodium storage capacity. Designing more confined pores in carbon anodes is accepted as an effective strategy. However, current design strategies for confined pores in carbon anodes fail to achieve both high capacity and initial Coulombic efficiency (ICE) simultaneously. Herein, we develop a strategy for utilizing the repeated impregnation and precarbonization method of liquid pitch to regulate the pore structure of the activated carbon (AC) material...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38532881/hycas9-12agep-an-efficient-genome-editing-platform-for-corynebacterium-glutamicum
#3
JOURNAL ARTICLE
Feng Zhang, Jin-Yu Wang, Chang-Lon Li, Wei-Guo Zhang
Corynebacterium glutamicum plays a crucial role as a significant industrial producer of metabolites. Despite the successful development of CRISPR-Cas9 and CRISPR-Cas12a-assisted genome editing technologies in C. glutamicum , their editing resolution and efficiency are hampered by the diverse on-target activities of guide RNAs (gRNAs). To address this problem, a hybrid CRISPR-Cas9-Cas12a genome editing platform (HyCas9-12aGEP) was developed in C . glutamicum in this study to co-express sgRNA (corresponding to Sp Cas9 guide RNA), crRNA (corresponding to Fn Cas12a guide RNA), or hfgRNA (formed by the fusion of sgRNA and crRNA)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38532188/amino-functional-magnetic-covalent-organic-framework-as-an-effective-adsorbent-for-the-determination-of-neonicotinoids-in-food-samples
#4
JOURNAL ARTICLE
Xinyue Zhang, Minli Yang, Feng Zhang, Xiujuan Wang, Feifang Zhang
Recently, covalent organic frameworks have gained popularity in sample pretreatment. However, the application of covalent organic frameworks in the enrichment of hydrophilic compounds remains a challenge. Thus, a functionalized magnetic covalent organic framework equipped with amino groups was constructed using a bottom-up functionalization strategy. Considering the advantages of this novel adsorbent such as high porosity, large adsorption capacity, and hydrophilic surface, a sensitive magnetic solid-phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry method was established for the effective determination of neonicotinoids...
March 26, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38529263/the-efficacy-of-chaihu-guizhi-ganjiang-decoction-on-chronic-non-atrophic-gastritis-with-gallbladder-heat-and-spleen-cold-syndrome-and-its-metabolomic-analysis-an-observational-controlled-before-after-clinical-trial
#5
Tao Wen, Xuan Liu, Tao Pang, Mingming Li, Guangyang Jiao, Xiangcheng Fan, Jigui Tang, Ci'an Zhang, Zhipeng Wang, Xiaoqiang Yue, Wansheng Chen, Feng Zhang
PURPOSE: The aim of this study was to verify the effectiveness and explore the mechanism of Chaihu-Guizhi-Ganjiang decoction (CGGD) in the treatment of chronic non-atrophic gastritis (CNAG) with gallbladder heat and spleen cold syndrome (GHSC) by metabolomics based on UHPLC-Q-TOF/MS. PATIENTS AND METHODS: An observational controlled before-after study was conducted to verify the effectiveness of CGGD in the treatment of CNAG with GHSC from January to June 2023, enrolling 27 patients, who took CGGD for 28 days...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38526064/dual-intervention-on-the-gut-and-skin-microbiota-attenuates-facial-cutaneous-aging
#6
JOURNAL ARTICLE
Liujing Zhang, Shun Yu, Yin Guan, Dan Wang, Ju Yang, Jingling Li, Wei Zhao, Feng Zhang
The gut and skin microbiota are microbial barriers, resisting harmful foreign microorganisms and maintaining internal homeostasis. Dysbiosis of the gut and skin microbiota is involved in aging progression. However, interventions targeting facial skin wellness taking into account the gut-skin axis are scarce. In this study, the impact of an eight-week intervention with oral (O), topical (T), and both oral and topical (OT) xylo-oligosaccharides (XOS) by regulating gut and skin microbiota on facial cutaneous aging was investigated in a double-blind placebo-controlled trial in females...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38523836/probiotics-effects-on-gut-microbiota-in-jaundiced-neonates-a-randomized-controlled-trial-protocol
#7
JOURNAL ARTICLE
Chen Jiayi, Wei Jinying, Yuan Yanhan, Liu Tianyu, Chen Juanjuan, Zhang Feng, Fang Xiaohui, Zhang Jinping
INTRODUCTION: Recent evidence suggests that blue-light phototherapy impacts gut microbiota composition in jaundiced newborns, leading to disturbances closely related to the therapy's side effects. As a result, gut microbiota may serve as a potential intervention target to mitigate these side effects. In this study, we aim to examine the effects of AB-GG (Lactobacillus rhamnosus LGG), Bb-12 (Bifidobacterium animalis Bb-12) and M-16V (Bifidobacterium breve M-16V) and their combination on the intestinal microbiota, metabolomics and phototherapy-related side effects in neonates with jaundice...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38523237/fucosyltransferase-8-regulates-adult-neurogenesis-and-cognition-of-mice-by-modulating-the-itga6-pi3k-akt-signaling-pathway
#8
JOURNAL ARTICLE
Hongfeng Guo, Qihang Sun, Xiaoli Huang, Xiaohao Wang, Feng Zhang, Wenzheng Qu, Jinling Liu, Xuejun Cheng, Qiang Zhu, Wen Yi, Qiang Shu, Xuekun Li
Fucosyltransferase 8 (Fut8) and core fucosylation play critical roles in regulating various biological processes, including immune response, signal transduction, proteasomal degradation, and energy metabolism. However, the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains unknown. We have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells (aNSPCs) and postnatal brain development...
March 22, 2024: Science China. Life Sciences
https://read.qxmd.com/read/38522312/catalpol-attenuates-ischemic-stroke-by-promoting-neurogenesis-and-angiogenesis-via-the-sdf-1%C3%AE-cxcr4-pathway
#9
JOURNAL ARTICLE
Mei-Feng Zhang, Jing-Hui Wang, Si Sun, Yi-Tong Xu, Dong Wan, Shan Feng, Zhen Tian, Hui-Feng Zhu
BACKGROUND: Stroke is a leading cause of disability and death worldwide. Currently, there is a lack of clinically effective treatments for the brain damage following ischemic stroke. Catalpol is a bioactive compound derived from the traditional Chinese medicine Rehmannia glutinosa and shown to be protective in various neurological diseases. However, the potential roles of catalpol against ischemic stroke are still not completely clear. PURPOSE: This study aimed to further elucidate the protective effects of catalpol against ischemic stroke...
January 15, 2024: Phytomedicine
https://read.qxmd.com/read/38521881/nnt-as1-in-cafs-derived-exosomes-promotes-progression-and-glucose-metabolism-through-mir-889-3p-hif-1%C3%AE-in-pancreatic-adenocarcinoma
#10
JOURNAL ARTICLE
Pingping Zhang, Qun Wang, Weijun Lu, Feng Zhang, Dongde Wu, Junwei Sun
It is metabolic and signaling crosstalk between stromal cells and tumors in the tumor microenvironment, which influences several aspects of tumor formation and drug resistance, including metabolic reprogramming. Despite considerable findings linking lncRNAs in HIF-1-related regulatory networks to cancer cell, little emphasis has been given to the role in communication between cancer-associated fibroblasts (CAFs) and tumor cells. Previously, we observed that NNT-AS1 was substantially expressed in CAFs cells and CAFs exosomes, and subsequently investigated the influence of CAFs exosomal NNT-AS1 on glucose metabolism, proliferation, and metastasis of pancreatic ductal adenocarcinoma (PDAC) cells...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38518855/risk-factors-of-non-suicidal-self-injury-of-youth-students-at-different-developmental-stages-during-covid-19-pandemic-in-jingzhou-china
#11
JOURNAL ARTICLE
Sherry Kit Wa Chan, Li-Fang Zhou, Jia Cai, Yingqi Liao, Yi Huang, Zhong-Yue Deng, Yu-Jun Liu, Xiao-Chuan Chen, Ru Gao, Xin-Feng Zhang, Yan-Qing Tao, Lie Zhou, Xiao-Peng Deng, Bo Liu, Mao-Sheng Ran
No abstract text is available yet for this article.
March 20, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38515760/crosstalk-between-ubiquitin-ligases-and-ncrnas-drives-cardiovascular-disease-progression
#12
REVIEW
Jia-Rui You, Zeng-Jin Wen, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Hui Xin, Pei-Feng Li, Yin-Feng Zhang, Rui Zhang
Cardiovascular diseases (CVDs) are multifactorial chronic diseases and have the highest rates of morbidity and mortality worldwide. The ubiquitin-proteasome system (UPS) plays a crucial role in posttranslational modification and quality control of proteins, maintaining intracellular homeostasis via degradation of misfolded, short-lived, or nonfunctional regulatory proteins. Noncoding RNAs (ncRNAs, such as microRNAs, long noncoding RNAs, circular RNAs and small interfering RNAs) serve as epigenetic factors and directly or indirectly participate in various physiological and pathological processes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515417/-clinical-effect-of-allogeneic-peroneal-bone-marrow-support-combined-with-plate-fixation-for-the-treatment-of-neer-type-%C3%A2-proximal-humeral-fractures
#13
JOURNAL ARTICLE
Zhen-Guo Sun, Zhan-Feng Zhang, Wen-Lin Hu, Zeng-Bing Xia
OBJECTIVE: To explore clinical effect of allogeneic peroneal bone marrow support combined with plate internal fixation in treating Neer type Ⅳproximal humeral fractures. METHODS: From December 2017 to December 2020,12 patients with Neer type Ⅳ proximal humeral fractures were treated with allogeneic peroneal bone marrow support combined with plate internal fixation,including 7 males and 5 females,aged from 56 to 78 years old;the time from injury to operation ranged from 1 to7 days...
March 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/38515416/-development-and-in-vivo-biomechanics-of-goat-mobile-artificial-lumbar-spine-complex
#14
JOURNAL ARTICLE
Feng Zhang, Xi-Jing He, Jian-Tao Liu, Rui Wang, Jie Qin, Quan-Jin Zang, Ting Zhang, Zhi-Yu Liu
OBJECTIVE: Mobile artificial lumbar complex (MALC) which suitable for reconstruction after subtotal lumbar resection in goats was developed,and to test stability of the complex and postoperative lumbar segmental motor function. METHODS: Eighteen male boer goats aged from 1 to 2 years old (weighted from 35 to 45 kg) were selected and divided into control group,fusion group and non-fusion group,with 6 goats in each group. According to preoperative CT scans and MRI examinations of lumbar,the goat MALC was designed and performed by 3D printed for non-fusion group...
March 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/38514420/innovative-pharmacotherapy-for-hepatic-metabolic-and-chronic-inflammatory-diseases-in-china
#15
REVIEW
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu Bian, Baofeng Yang
Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non-alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type of cancer. Despite the scarcity of innovative treatment options, Chinese hepatologists and researchers have achieved notable breakthroughs in the prevention, diagnosis, management and treatment of liver diseases...
March 21, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38513931/metabolomic-profiling-of-serum-and-tongue-coating-of-pregnant-women-with-intrahepatic-cholestasis-in-pregnancy
#16
JOURNAL ARTICLE
Feng Zhang, Fang Liu, Xiaoyi Xu, Weilan Su, Yu Rong, Fu-Ying Tian, Weimin Xiao, Yichun Wu, Kai P Law, Ping Wen
Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of cesarean section and adverse fetal outcomes. Currently, ICP diagnosis depends largely on serum levels of bile acids and lacks sensitivity and specificity for accurate diagnosis. Tongue diagnosis is an important diagnostic tool in traditional Chinese medicine (TCM) and is used in our clinic as complementary treatment and personalized medicine for ICP. However, the molecular basis of the manifestation of greasy white tongue coatings in ICP remains unknown...
March 19, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38513778/bao-yuan-decoction-alleviates-fatigue-by-restraining-inflammation-and-oxidative-stress-via-the-ampk-cry2-per1-signaling-pathway
#17
JOURNAL ARTICLE
Yuan Zheng, Xueyang Ren, Xiaodan Qi, Ruolan Song, Chongjun Zhao, Jiamu Ma, Xianxian Li, Qingyue Deng, Yingyu He, Lingmei Kong, Liyan Qian, Feng Zhang, Mingxia Li, Mengyu Sun, Wei Liu, Haibin Liu, Gaimei She
ETHNOPHARMACOLOGICAL RELEVANCE: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating deficiency, labor and cowardice, deficiency of vital energy. In researches related to anti-fatigue effects, the reciprocal regulation of AMPK and circadian clocks likely plays an important role in anti-fatigue mechanism, while it has not yet been revealed. Therefore, we elucidated the anti-fatigue mechanism of BYD through AMPK/CRY2/PER1 pathway...
March 19, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38512331/light-quality-adapted-carotenoid-photoprotection-in-the-photosystem-of-roseiflexus-castenholzii
#18
JOURNAL ARTICLE
Jin-Fang Hao, Chen-Hui Qi, Bu-Yang Yu, Hao-Yi Wang, Rong-Yao Gao, Nami Yamano, Fei Ma, Peng Wang, Yue-Yong Xin, Chun-Feng Zhang, Long-Jiang Yu, Jian-Ping Zhang
The photosystem of filamentous anoxygenic phototroph Roseiflexus ( Rfl .) castenholzii comprises a light-harvesting (LH) complex encircling a reaction center (RC), which intensely absorbs blue-green light by carotenoid (Car) and near-infrared light by bacteriochlorophyll (BChl). To explore the influence of light quality (color) on the photosynthetic activity, we compared the pigment compositions and triplet excitation dynamics of the LH-RCs from Rfl . castenholzii was adapted to blue-green light ( bg -LH-RC) and to near-infrared light ( nir -LH-RC)...
March 21, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38511382/-research-progress-on-biomass-ash-carbon-capture-and-storage
#19
JOURNAL ARTICLE
Song-Bin Wu, Ming-Jing Ma, Jiao-Yue Wang, Le Niu, Wen-Feng Zhang, Xiao-Wei Xu, Feng-Ming Xi
Carbon capture and storage (CCS) technology is an important way to slow down the continuous increase in atmospheric CO2 concentration and to achieve the dual carbon target. Carbon capture and storage through biomass ash is a secure, permanent, and environment friendly way. To better understand the characteristics of biomass ash carbon capture and storage, we summarized progresses on biomass ash carbon capture and storage, clarified the mechanisms of biomass ash carbon sequestration, analyzed the influencing factors, and explored its applications in various domains...
December 2023: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://read.qxmd.com/read/38510304/is-the-expression-of-different-discrete-emotions-related-to-time-evidence-from-online-chinese-reviews-using-sentiment-analysis-and-human-behavior-dynamics
#20
JOURNAL ARTICLE
Liu Li-Na, Qi Jia-Yin, Wang Sheng-Feng, Zhang Zhen-Ping, Qu Qi-Xing
OBJECTIVES: The online behavior of online users has taken on complex and diverse characteristics, and posting product reviews on e-commerce platforms is no exception. In fact, reviews contain rich and multi-dimensional discrete emotional information, and whether there is a relationship between the expression of these different discrete emotions and the time interval between product purchase and review posting as well as their related characteristics are the issues that this study needs to analyze and solve in depth...
2024: Frontiers in Psychology
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