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"Feng Zhang"

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https://www.readbyqxmd.com/read/28339018/role-of-autophagy-in-the-progression-of-osteoarthritis-the-autophagy-inhibitor-3-methyladenine-aggravates-the-severity-of-experimental-osteoarthritis
#1
Ni-Tao Cheng, Hai Meng, Li-Feng Ma, Liang Zhang, Hao-Miao Yu, Zhen-Zhong Wang, Ai Guo
Accumulating evidence suggests that autophagy is closely related to the pathogenesis of osteoarthritis (OA). The aim of this study was to determine the changes in autophagy during the progression of OA and to elucidate the specific role of autophagy in OA. For this purpose, a cellular model of OA was generated by stimulating SW1353 cells with interleukin (IL)-1β and a rabbit model of OA was also established by an intra-articular injection of collagenase, followed by treatment with the autophagy specific inhibitor, 3-methyladenine (3-MA)...
March 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28337987/high-performance-and-compact-designed-flexible-thermoelectric-modules-enabled-by-a-reticulate-carbon-nanotube-architecture
#2
Wenbin Zhou, Qingxia Fan, Qiang Zhang, Le Cai, Kewei Li, Xiaogang Gu, Feng Yang, Nan Zhang, Yanchun Wang, Huaping Liu, Weiya Zhou, Sishen Xie
It is a great challenge to substantially improve the practical performance of flexible thermoelectric modules due to the absence of air-stable n-type thermoelectric materials with high-power factor. Here an excellent flexible n-type thermoelectric film is developed, which can be conveniently and rapidly prepared based on the as-grown carbon nanotube continuous networks with high conductivity. The optimum n-type film exhibits ultrahigh power factor of ∼1,500 μW m(-1) K(-2) and outstanding stability in air without encapsulation...
March 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28335670/different-lengths-copies-and-expression-levels-of-the-mitochondrial-atp6-gene-in-male-sterile-and-fertile-lines-of-carrot-daucus-carota-l
#3
Guo-Fei Tan, Feng Wang, Xin-Yue Zhang, Ai-Sheng Xiong
The male-sterile carrot is an effective material for carrot breeding. The atp6 gene is involved in carrot fertility. However, the differences in lengths, copies, and expression profiles of the atp6 gene in fertile and male-sterile lines of carrot are unclear. In this study, one copy atp6 gene was found in the mtDNAs of 'Kuroda' (fertility, 954 bp) and 'Wuye-BY' (male sterility, 819 bp) carrot lines, while two copies atp6 genes (Wuye-L and Wuye-D, 954 bp and 819 bp, respectively) were found in the mtDNA of 'Wuye' (fertility)...
March 23, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28335366/nano-copper-oxide-modified-carbon-cloth-as-cathode-for-a-two-chamber-microbial-fuel-cell
#4
Feng Dong, Peng Zhang, Kexun Li, Xianhua Liu, Pingping Zhang
In this work, Cu₂O nanoparticles were deposited on a carbon cloth cathode using a facile electrochemical method. The morphology of the modified cathode, which was characterized by scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) tests, showed that the porosity and specific surface area of the cathode improved with longer deposition times. X-ray photoelectron spectroscopy (XPS) and cyclic voltammetry (CV) results showed that cupric oxide and cuprous oxide coexisted on the carbon cloth, which improved the electrochemical activity of cathode...
December 9, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28326861/cutaneous-applied-nano-zno-reduce-the-ability-of-hair-follicle-stem-cells-to-differentiate
#5
Wei Ge, Yong Zhao, Fang-Nong Lai, Jing-Cai Liu, Yuan-Chao Sun, Jun-Jie Wang, Shun-Feng Cheng, Xi-Feng Zhang, Li-Lan Sun, Lan Li, Paul W Dyce, Wei Shen
The ability of metal oxide nanoparticles to penetrate the skin has aroused a great deal of interest during the past decade due to concerns over the safety of topically applied sunscreens that contain physical UV-resistant metal particles, such as nano-Zinc oxide (nZnO). Previous studies demonstrate that metal oxide nanoparticles accumulate in skin furrows and hair follicles following topical application while little is known about the consequence of these nanoparticles on skin homeostasis. The current investigation tested the effects of nZnO (0...
March 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28326786/solvent-free-mechanosynthesis-of-composition-tunable-cesium-lead-halide-perovskite-quantum-dots
#6
Zhi-Yuan Zhu, Qi-Qi Yang, Lin-Feng Gao, Lei Zhang, An-Ye Shi, Chun-Lin Sun, Qiang Wang, Hao-Li Zhang
A facile and green mechanosynthesis strategy free of solvent and high reaction temperature was developed to fabricate highly emissive cesium lead halide perovskite (CsPbX3) quantum dots (QDs). Their composition can be adjusted conveniently simply through mechanically milling/grinding stoichiometric combinations of raw reagents, thereby introducing a broad luminescence tunability of the product with adjustable wavelength, linewidth and photoluminescence quantum yield. Desired CsPbX3 QDs "library" can thus be readily constructed in a way like assembling Lego building blocks...
March 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28325916/automatic-time-shift-alignment-method-for-chromatographic-data-analysis
#7
Qing-Xia Zheng, Hai-Yan Fu, He-Dong Li, Bing Wang, Cui-Hua Peng, Sheng Wang, Jun-Lan Cai, Shao-Feng Liu, Xiao-Bing Zhang, Yong-Jie Yu
Time shift among samples remains a significant challenge in data analysis, such as quality control of natural plant extracts and metabolic profiling analysis, because this phenomenon may lead to invalid conclusions. In this work, we propose a new time shift alignment method, namely, automatic time-shift alignment (ATSA), for complicated chromatographic data analysis. This technique comprised the following alignment stages: (1) automatic baseline correction and peak detection stage for providing useful chromatographic information; (2) preliminary alignment stage through adaptive segment partition to correct alignment for the entire chromatogram; and (3) precise alignment stage based on test chromatographic peak information to accurately align time shift...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322061/potential-biomarkers-for-monitoring-the-toxicity-of-long-term-exposure-to-atrazine-in-rat-by-metabonomic-analysis
#8
Xiao-Feng Zhang, Chong-Hua Zhang, Jing Zheng, Long-Xue Li, Tian-Qi Geng, Yang Zhang
1. Herbicide atrazine (ATR) poses harmful effects on human health. The purpose of this study is to study potential biomarkers used for monitoring the toxic effects after chronic exposure to ATR by studying urine metabolites. 2. Rats were assigned into clinical chemistry and metabonomics arms, and each arm was divided into low-dose, high-dose and control groups. ATR was administered to rats along with their feed. At the end of 16, 20 and 24 weeks, clinical parameters and histopathologic changes was assessed to monitor the toxic effects...
March 21, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28314593/25-hydroxycholesterol-protects-host-against-zika-virus-infection-and-its-associated-microcephaly-in-a-mouse-model
#9
Chunfeng Li, Yong-Qiang Deng, Shuo Wang, Feng Ma, Roghiyh Aliyari, Xing-Yao Huang, Na-Na Zhang, Momoko Watanabe, Hao-Long Dong, Ping Liu, Xiao-Feng Li, Qing Ye, Min Tian, Shuai Hong, Junwan Fan, Hui Zhao, Lili Li, Neda Vishlaghi, Jessie E Buth, Connie Au, Ying Liu, Ning Lu, Peishuang Du, F Xiao-Feng Qin, Bo Zhang, Danyang Gong, Xinghong Dai, Ren Sun, Bennett G Novitch, Zhiheng Xu, Cheng-Feng Qin, Genhong Cheng
Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated, and effective therapeutics are not currently available. Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25-hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. Synthetic 25HC addition inhibited ZIKV infection in vitro by blocking viral entry, and treatment with 25HC reduced viremia and conferred protection against ZIKV in mice and rhesus macaques...
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28314243/parthenolide-attenuates-cerebral-ischemia-reperfusion-injury-via-akt-gsk-3%C3%AE-pathway-in-pc12-cells
#10
Jun-Feng Zhang, Li Zhang, Li-Li Shi, Zhao-Hua Zhao, Hao Xu, Fei Liang, Hong-Bo Li, Yan Zhao, Xi Xu, Ke Yang, Ying-Fang Tian
Parthenolide (PN), a sesquiterpene lactone isolated from the herbal medicine feverfew (Tanacetum parthenium), was reported to possess neuroprotective activity. However, the neuroprotective effect of PN against cerebral ischemia/reperfusion (I/R) injury remains unclear. Therefore, the aim of the present study was to explore the neuroprotective effects of PN against oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells and the underlying mechanisms. Our results demonstrated that PN ameliorated OGD/R-evoked neuronal injury and oxidative stress in PC12 cells...
March 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28297007/cardiopulmonary-resuscitation-training-in-china-current-situation-and-future-development
#11
Feng Xu, Yun Zhang, Yuguo Chen
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28287726/organocatalytic-enantioselective-michael-cyclization-domino-reaction-between-3-amideoxindoles-and-%C3%AE-%C3%AE-unsaturated-aldehydes-one-pot-preparation-of-chiral-spirocyclic-oxindole-%C3%AE-lactams
#12
Peng Yang, Xiao Wang, Feng Chen, Zheng-Bing Zhang, Chao Chen, Lin Peng, Li-Xin Wang
The first organocatalytic enantioselective Michael/cyclization domino reaction between 3-amideoxindoles and α,β-unsaturated aldehydes is described. After sequential oxidation with pyridinium chlorochromate, a direct and one-pot preparation of highly sterically hindered spirocyclic oxindole-γ-lactams was achieved in 51-81% yields with 75-97% ee and ≤80/20 dr.
March 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28287720/discovery-of-novel-pyridone-conjugated-monosulfactams-as-potent-and-broad-spectrum-antibiotics-for-multidrug-resistant-gram-negative-infections
#13
Liang Tan, Yunliang Tao, Ting Wang, Feng Zou, Shuhua Zhang, Qunhuan Kou, Ao Niu, Qian Chen, Wenjing Chu, Xiaoyan Chen, Haidong Wang, Yushe Yang
Conjugating a siderophore to an antibiotic is a promising strategy to overcome the permeability-mediated resistance of Gram-negative pathogens. Based on the structure of BAL30072, novel pyridone-conjugated monosulfactams incorporating diverse substituents into the methylene linker between the 1,3-dihydroxypyridin-4(1H)-one and the aminothiazole oxime were designed and synthesized. Structure-activity relationship studies revealed that a variety of substituents were tolerated, with isopropyl (compound 12c) and methylthiomethyl (compound 16a) showing the best efficacy against multidrug-resistant (MDR) Gram-negative pathogens...
March 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28286887/copper-catalyzed-propargylation-of-diborylmethane
#14
Feng Li, Zhen-Qi Zhang, Xi Lu, Bin Xiao, Yao Fu
A Cu/PPh3-catalyzed propargylic substitution reaction of diborylmethane is reported. Different substituted propargyl electrophiles can be employed in this reaction, and various synthetic valuable functional groups can be tolerated. Di-deuterated diborylmethane can also be used under these conditions and generates α-deuterated alkylboronic esters in good yield.
March 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28277438/endoscopic-sphincterotomy-for-gallbladder-muddy-stones-or-sludge-in-patients-with-papillary-disease-a-retrospective-study
#15
Cheng Zhang, Yu-Long Yang, Yue-Feng Ma, Hong-Wei Zhang, Li-Jun Shi, Jing-Yi Li, Mei-Ju Lin, Chun-Chun Qi
BACKGROUND: The formation of gallbladder stones is associated with dysfunctional contraction and duodenal papilla diseases. However, endoscopic sphincterotomy can improve the contraction of the gallbladder and resolve duodenal papilla disease. AIM: The aim of the study was to assess the feasibility and effectiveness of endoscopic sphincterotomy in the treatment of muddy stones or sludge in the gallbladder during papillary disease. METHODS: The clinical data of 53 patients with gallbladder muddy stones or sludge undergoing endoscopic sphincterotomy were retrospectively analyzed...
March 8, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28271881/core-shell-nanoparticle-enhanced-raman-spectroscopy
#16
Jian-Feng Li, Yue-Jiao Zhang, Song-Yuan Ding, Rajapandiyan Panneerselvam, Zhong-Qun Tian
Core-shell nanoparticles are at the leading edge of the hot research topics and offer a wide range of applications in optics, biomedicine, environmental science, materials, catalysis, energy, and so forth, due to their excellent properties such as versatility, tunability, and stability. They have attracted enormous interest attributed to their dramatically tunable physicochemical features. Plasmonic core-shell nanomaterials are extensively used in surface-enhanced vibrational spectroscopies, in particular, surface-enhanced Raman spectroscopy (SERS), due to the unique localized surface plasmon resonance (LSPR) property...
March 8, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28267440/identification-of-novel-b-raf-v600e-inhibitors-employing-fbdd-strategy
#17
Peng-Fei Wang, Han-Yue Qiu, Ze-Feng Wang, Yong-Jiao Zhang, Zhong-Chang Wang, Dong-Dong Li, Hai-Liang Zhu
B-Raf kinase is the key point in a main branch of mitogen-activated protein kinase pathways and some of its mutations, such as the V600E mutation, lead to the persistent activation of ERK signaling and the trigger of severe diseases, including melanoma and other somatic cancers. Several potent drugs have been approved to treat B-Raf-related tumors, however, cases of resistance and relapse have been reported universally. Hence, differential scaffolds are in need to alleviate the scarcity of drugs and benefit the therapy of B-Raf-mutant cancers...
March 4, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28266809/acpi-conjugated-gold-nanorods-as-nanoplatform-for-dual-image-guided-activatable-photodynamic-and-photothermal-combined-therapy-in-vivo
#18
Wen-Xiu Qiu, Li-Han Liu, Shi-Ying Li, Qi Lei, Guo-Feng Luo, Xian-Zheng Zhang
The nanoplatform GNR-ACPP-PpIX (designated as GNR-ACPI) is designed for dual image guided combined activatable photodynamic therapy (PDT) and photothermal therapy (PTT). In GNR-ACPI, gold nanorods (GNRs) are modified with a protoporphyrin (PpIX, a PDT agent) conjugated activatable cell penetrating peptide (ACPP), which consists of the matrix metalloproteinases-2 (MMP-2) sensitive peptide sequence GPLGLAG. First, the photoactivity of PpIX is effectively quenched by GNRs due to the strong near infrared region light absorption of GNR and the special "U type" structure of ACPP induced close contact between PpIX and GNR...
March 7, 2017: Small
https://www.readbyqxmd.com/read/28262666/a-class-of-liquid-anode-for-rechargeable-batteries-with-ultralong-cycle-life
#19
Juezhi Yu, Yong-Sheng Hu, Feng Pan, Zhizhen Zhang, Qing Wang, Hong Li, Xuejie Huang, Liquan Chen
Low cost, highly efficient and safe devices for energy storage have long been desired in our society. Among these devices, electrochemical batteries with alkali metal anodes have attracted worldwide attention. However, the practical application of such systems is limited by dendrite formation and low cycling efficiency of alkali metals. Here we report a class of liquid anodes fabricated by dissolving sodium metal into a mixed solution of biphenyl and ethers. Such liquid anodes are highly safe and have a low redox potential of 0...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28260782/control-of-secondary-cell-wall-patterning-involves-xylan-deacetylation-by-a-gdsl-esterase
#20
Baocai Zhang, Lanjun Zhang, Feng Li, Dongmei Zhang, Xiangling Liu, Hang Wang, Zuopeng Xu, Chengcai Chu, Yihua Zhou
O-acetylation, a ubiquitous modification of cell wall polymers, has striking impacts on plant growth and biomass utilization and needs to be tightly controlled. However, the mechanisms that underpin the control of cell wall acetylation remain elusive. Here, we show a rice brittle leaf sheath1 (bs1) mutant, which contains a lesion in a Golgi-localized GDSL esterase that deacetylates the prominent hemicellulose xylan. Cell wall composition, detailed xylan structure characterization and enzyme kinetics and activity assays on acetylated sugars and xylooligosaccharides demonstrate that BS1 is an esterase that cleaves acetyl moieties from the xylan backbone at O-2 and O-3 positions of xylopyranosyl residues...
March 3, 2017: Nature Plants
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