Yuan Zheng, Xueyang Ren, Xiaodan Qi, Ruolan Song, Chongjun Zhao, Jiamu Ma, Xianxian Li, Qingyue Deng, Yingyu He, Lingmei Kong, Liyan Qian, Feng Zhang, Mingxia Li, Mengyu Sun, Wei Liu, Haibin Liu, Gaimei She
ETHNOPHARMACOLOGICAL RELEVANCE: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating deficiency, labor and cowardice, deficiency of vital energy. In researches related to anti-fatigue effects, the reciprocal regulation of AMPK and circadian clocks likely plays an important role in anti-fatigue mechanism, while it has not yet been revealed. Therefore, we elucidated the anti-fatigue mechanism of BYD through AMPK/CRY2/PER1 pathway...
March 19, 2024: Journal of Ethnopharmacology