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"Feng Zhang"

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https://www.readbyqxmd.com/read/28717189/cdk5-mediated-phosphorylation-of-xbp1s-contributes-to-its-nuclear-translocation-and-activation-in-mpp-induced-parkinson-s-disease-model
#1
Feng-Juan Jiao, Qing-Zhi Wang, Pei Zhang, Jian-Guo Yan, Zheng Zhang, Feng He, Qian Zhang, Ze-Xi Lv, Xiang Peng, Hong-Wei Cai, Bo Tian
Parkinson's disease (PD) is an irreversible and progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta. Growing evidence indicates that endoplasmic reticulum stress is a hallmark of PD; however, its exact contribution to the disease process remains poorly understood. Here, we used molecular biology methods and RNA-Seq analysis to explored an unexpected role of spliced X-Box binding protein 1 (XBP1s) in the nervous system. In this study, we determined that the IRE1α/XBP1 pathway is activated in MPP(+)-treated neurons...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716920/vamp3-and-snap23-mediate-the-disturbed-flow-induced-endothelial-microrna-secretion-and-smooth-muscle-hyperplasia
#2
Juan-Juan Zhu, Yue-Feng Liu, Yun-Peng Zhang, Chuan-Rong Zhao, Wei-Juan Yao, Yi-Shuan Li, Kuei-Chun Wang, Tse-Shun Huang, Wei Pang, Xi-Fu Wang, Xian Wang, Shu Chien, Jing Zhou
Vascular endothelial cells (ECs) at arterial branches and curvatures experience disturbed blood flow and induce a quiescent-to-activated phenotypic transition of the adjacent smooth muscle cells (SMCs) and a subsequent smooth muscle hyperplasia. However, the mechanism underlying the flow pattern-specific initiation of EC-to-SMC signaling remains elusive. Our previous study demonstrated that endothelial microRNA-126-3p (miR-126-3p) acts as a key intercellular molecule to increase turnover of the recipient SMCs, and that its release is reduced by atheroprotective laminar shear (12 dynes/cm(2)) to ECs...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28713408/transcriptome-analyses-shed-new-insights-into-primary-metabolism-and-regulation-of-blumeria-graminis-f-sp-tritici-during-conidiation
#3
Fan-Song Zeng, Fabrizio Menardo, Min-Feng Xue, Xue-Jiang Zhang, Shuang-Jun Gong, Li-Jun Yang, Wen-Qi Shi, Da-Zhao Yu
Conidia of the obligate biotrophic fungal pathogen Blumeria graminis f. sp. tritici (Bgt) play a vital role in its survival and rapid dispersal. However, little is known about the genetic basis for its asexual reproduction. To uncover the primary metabolic and regulatory events during conidiation, we sequenced the transcriptome of Bgt epiphytic structures at 3 (vegetative hyphae growth), 4 (foot cells initiation), and 5 (conidiophore erection) days post-inoculation (dpi). RNA-seq analyses identified 556 and 404 (combined 685) differentially expressed genes (DEGs) at 4 and 5 dpi compared with their expression levels at 3 dpi, respectively...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28705936/cd14-is-a-key-mediator-of-both-lysophosphatidic-acid-and-lipopolysaccharide-induction-of-foam-cell-formation
#4
Dong An, Feng Hao, Fuqiang Zhang, Wei Kong, Jerold Chun, Xuemin Xu, Mei-Zhen Cui
Macrophage uptake of oxidized lowdensity lipoprotein (oxLDL) plays an important role in foam cell formation and the pathogenesis of atherosclerosis. We report here that lysophosphatidic acid (LPA) enhances lipopolysaccharide (LPS)-induced oxLDL uptake in macrophages. Our data revealed that both LPA and LPS highly induce the CD14 expression at messenger RNA and protein levels in macrophages. The role of CD14, one component of the LPS receptor cluster, in LPA-induced biological functions has been unknown. We took several steps to examine the role of CD14 in LPA signaling pathways...
July 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28702375/a-single-nucleotide-polymorphism-is-involved-in-regulation-of-growth-and-spore-formation-of-bacillus-anthracis-pasteur-ii-strain
#5
Xudong Liang, Jin Zhu, Zhongzhi Zhao, Feng Zheng, Enmin Zhang, Jianchun Wei, Yon Ji, Yinduo Ji
Anthrax toxins and capsules, which are encoded by genes located on pXO1 and pXO2, respectively, are major virulence factors of Bacillus anthracis. Our previous studies demonstrated that exposure to high-temperatures is unable to abolish the pXO1 plasmid of the Pasteur II strain, but the growth of the strain was obviously slower than that of the Sterne strain and wild-type virulent strain. To elucidate a potential regulatory mechanism of slowing growth, we employed comparative genome and bioinformatic analysis and revealed a unique SNP (G to T) at the 143135 bp position in pXO1 that is possibly involved in the mediation of growth of Pasteur II...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28696657/a-3d-structural-model-of-high-performance-non-fullerene-polymer-solar-cells-as-revealed-by-high-resolution-afm
#6
Shaowei Shi, Xiaofeng Chen, Xubo Liu, Xuefei Wu, Feng Liu, Zhi-Guo Zhang, Yongfang Li, Thomas P Russell, Dong Wang
Rapid improvements in non-fullerene polymer solar cells (PSCs) have brought power conversion efficiencies to over 12%. To further improve device performance, a fundamental understanding of the correlations between structure and performance is essential. In this paper, based on a typical high performance system consisting of J61(one donor-acceptor (D-A) copolymer of benzodithiophene and fluorine substituted benzotriazole) and ITIC (3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone)-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']-dithiophene), a 3D-structural model is directly imaged by employing high resolution atomic force microscopy (AFM)...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28696100/thermosensitive-liposomal-co-delivery-of-hsa-paclitaxel-and-hsa-ellagic-acid-complexes-for-enhanced-drug-perfusion-and-efficacy-against-pancreatic-cancer
#7
Yan Wei, Yuxi Wang, Dengning Xia, Shiyan Guo, Feng Wang, Xinxin Zhang, Yong Gan
Fibrotic stroma and tumor-promoting pancreatic stellate cells (PSCs), critical characters in the pancreatic ductal adenocarcinoma (PDA) microenvironment, promote a tumor-facilitating environment that simultaneously prevents drug penetration into tumor foci and stimulates tumor growth. Nab-PTX, a human serum albumin (HSA) nanoparticle of paclitaxel (PTX), indicates enhanced matrix penetration in PDA probably due to its small size in vivo and high affinity of HSA with secreted protein acidic and rich in cysteine (SPARC), overexpressed in the PDA stroma...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28695807/effect-of-transverse-position-and-numbers-on-the-stability-of-the-spinal-pedicle-screw-fixation-during-the-pedicle-cortex-perforation
#8
Zhen Wang, Feng Su, Xiangyu Zhang, Shi Yan, Zhimin Zhang
Objective To evaluate the effect of transverse position and numbers on the stability of the spinal pedicle screw fixation during the pedicle cortex perforation. Methods The vertebral compression fracture was performed in the L1 vertebral body using the Chiba's method from 60 fresh thoracic and lumbar vertebrae samples of sheep(T13-L3),which were randomly divided into 6 groups(A,B,C,D,E,and F)using a lottery method. Bilateral pedicles of vertebral arch of T14 and L2 were inserted pedicle screws,connecting titanium rods to fix T14-L2 segments...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28692279/hot-electron-intraband-luminescence-from-gaas-nanospheres-mediated-by-magnetic-dipole-resonances
#9
Jin Xiang, Shuai Jiang, Jingdong Chen, Jinxiang Li, Qiaofeng Dai, Chengyun Zhang, Yi Xu, Shaolong Tie, Sheng Lan
Significantly enhanced electric field in plasmonic hot spots can dramatically increase the linear and nonlinear absorption of light, leading to a high-temperature electron gas which radiates, through mainly intraband transition, a broadband luminescence quite similar to blackbody radiation. Here, we demonstrate that such hot-electron intraband luminescence (HEIL) can also be achieved by exploiting the significantly enhanced electric field at the magnetic dipole resonances of gallium arsenide (GaAs) nanospheres (NSs)...
July 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28688239/successful-treatment-of-toxic-epidermal-necrolysis-using-plasmapheresis-a-prospective-observational-study
#10
Feng Han, Jingjing Zhang, Qi Guo, Yanjing Feng, Ya Gao, Litao Guo, Yanli Hou, Jingang An, Xiaopeng Wang, Bin Yan, Yan Zheng, Jingchun Song, Manxiang Li, Gang Wang
Toxic epidermal necrolysis (TEN) is a rare, severe, life-threatening skin disease and it requires urgent critical care, including admission to the intensive care unit (ICU). It is characterized by fatal sequelae and high mortality. Currently, insufficient evidence exists to support the use of any systemic adjuvant therapy, such as cyclophosphamide, intravenous immunoglobulin (IVIg), or corticosteroids. However, plasmapheresis has been increasingly valued by clinicians due to its significant efficacy and little adverse side effects...
July 1, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28686902/silk-fibroin-coated-plga-dimpled-microspheres-for-retarded-release-of-simvastatin
#11
Feng Qiao, Junjiang Zhang, Jianghong Wang, Bo Du, Xiaohuan Huang, Liyun Pang, Zhimin Zhou
The surface physical features and chemical components of polymeric particles play an important role in drug delivery systems. In this study, PLGA blank microspheres and simvastatin-loaded PLGA microspheres with dimpled surface structure were prepared by single emulsion-solvent evaporation method in the absence of any additives. Subsequently, glutaraldehyde cross-linking was optimized for silk fibroin coating on simvastatin-loaded PLGA dimpled microspheres due to good solubility of simvastatin in alcohol. Furthermore, simvastatin release kinetics was investigated for silk-coated or plain PLGA dimpled microspheres...
June 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28686722/the-changes-of-gut-microbiota-after-acute-myocardial-infarction-in-rats
#12
Ze-Xuan Wu, Su-Fang Li, Hong Chen, Jun-Xian Song, Yuan-Feng Gao, Feng Zhang, Cheng-Fu Cao
Recent studies suggested that gut microbiota was involved in the development of coronary artery disease. However, the changes of gut microbiota following acute myocardial infarction (AMI) remain unknown. In this study, a total of 66 male Wistar rats were randomly divided into control, AMI and SHAM groups. The controls (n = 6) were sacrificed after anesthesia. The AMI model was built by ligation of left anterior descending coronary artery. The rats of AMI and SHAM groups were sacrificed at 12 h, 1 d, 3 d, 7 d and 14 d post-operation respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28685585/the-effects-of-combined-selenium-nanoparticles-and-radiation-therapy-on-breast-cancer-cells-in-vitro
#13
Feng Chen, Xiao Hong Zhang, Xiao Dan Hu, Pei Dang Liu, Hai Qian Zhang
Radiosensitizers that increase cancer cell radio-sensitivity can enhance the effectiveness of irradiation and minimize collateral damage. Nanomaterial has been employed in conjunction with radiotherapy as radiosensitizers, due to its unique physicochemical properties. In this article, we evaluated selenium nanoparticles (Nano-Se) as a new radiosensitizer. Nano-Se was used in conjunction with irradiation on MCF-7 breast cancer cells, and efficacy and mechanisms of this combined treatment approach were evaluated...
July 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28679380/a-novel-botanical-formula-prevents-diabetes-by-improving-insulin-resistance
#14
Juntao Kan, Rodney A Velliquette, Kerry Grann, Charlie R Burns, Jeff Scholten, Feng Tian, Qi Zhang, Min Gui
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigonella foenum graecum) seed, mulberry (Morus alba L.) leaf and American ginseng (Panax quinquefolius) root can improve glycemia in various animal models and humans with impaired glucose metabolism and T2DM. The aim of this study was to design an optimized botanical formula containing these herbal extracts as a nutritional strategy for the prevention of insulin resistance and T2DM...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28678752/what-is-the-optimal-radiation-dose-for-non-operable-esophageal-cancer-dissecting-the-evidence-in-a-meta-analysis
#15
Yong Chen, Hui-Ping Zhu, Tao Wang, Chang-Jiang Sun, Xiao-Lin Ge, Ling-Feng Min, Xian-Wen Zhang, Qing-Qing Jia, Jie Yu, Jian-Qi Yang, Heike Allgayer, Mohammed L Abba, Xi-Zhi Zhang, Xin-Chen Sun
The standard radiation dose 50.4 Gy with concurrent chemotherapy for localized inoperable esophageal cancer as supported by INT-0123 trail is now being challenged since a radiation dose above 50 Gy has been successfully administered with an observable dose-response relationship and insignificant untoward effects. Therefore, to ascertain the treatment benefits of different radiation doses, we performed a meta-analysis with 18 relative publications. According to our findings, a dose between 50 and 70 Gy appears optimal and patients who received ≥ 60 Gy radiation had a significantly better prognosis (pooled HR = 0...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28677949/preparation-of-mno2-modified-graphite-sorbents-from-spent-li-ion-batteries-for-the-treatment-of-water-contaminated-by-lead-cadmium-and-silver
#16
Tuo Zhao, Ying Yao, Meiling Wang, Renjie Chen, Yajuan Yu, Feng Wu, Cunzhong Zhang
Herein, a novel adsorbent was prepared via grafting MnO2 particles on graphite recovered from spent lithium-ion batteries to treat water contaminated by lead, cadmium, and silver. This is the first study reporting the recovery of spent LIB anode material and its application to heavy-metal-contaminated wastewater treatment. Characterizations using scanning electron microscopy, energy-dispersive X-ray analysis, and Fourier transform infrared showed that the adsorbent surface was coated with MnO2 ultrafine particles that served as the sorption mechanism to remove heavy-metal ions...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28676847/in-cell-western-assays-to-evaluate-hantaan-virus-replication-as-a-novel-approach-to-screen-antiviral-molecules-and-detect-neutralizing-antibody-titers
#17
Hong-Wei Ma, Wei Ye, He-Song Chen, Tie-Jian Nie, Lin-Feng Cheng, Liang Zhang, Pei-Jun Han, Xing-An Wu, Zhi-Kai Xu, Ying-Feng Lei, Fang-Lin Zhang
Hantaviruses encompass rodent-borne zoonotic pathogens that cause severe hemorrhagic fever disease with high mortality rates in humans. Detection of infectious virus titer lays a solid foundation for virology and immunology researches. Canonical methods to assess viral titers rely on visible cytopathic effects (CPE), but Hantaan virus (HTNV, the prototype hantavirus) maintains a relatively sluggish life cycle and does not produce CPE in cell culture. Here, an in-cell Western (ICW) assay was utilized to rapidly measure the expression of viral proteins in infected cells and to establish a novel approach to detect viral titers...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28674954/biosynthesis-of-staphylococcal-enterotoxin-a-by-genetic-engineering-technology-and-determination-of-staphylococcal-enterotoxin-a-in-water-by-hplc-esi-tof
#18
Hong-Na Li, Fei Yuan, Yun-Jing Luo, Jian-Feng Wang, Chuan-Bin Zhang, Wei-E Zhou, Zhi-Qin Ren, Wen-Jie Wu, Feng Zhang
Staphylococcal enterotoxin A (SEA) was the major virulence factor of Staphylococcus aureus and a biomarker of S. aureus. To establish a fast, low cost, high accuracy, reliable, and simple method for detecting S. aureus, SEA was analyzed by HPLC-ESI-TOF. SEA was not yet commercially available in universal, so SEA was prepared before it was analyzed by HPLC-ESI-TOF. The result showed that high purified SEA was successfully prepared and SEA has normal distribution in mass spectra. A large amount of recombinant SEA (rSEA) was obtained by engineering technology and was purified by Ni affinity chromatography column, and the expression and purity of rSEA and SEA were analyzed by SDS-PAGE...
July 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28674223/expression-analysis-of-argonaute-dicer-like-and-rna-dependent-rna-polymerase-genes-in-cucumber-cucumis-sativus-l-in-response-to-abiotic-stress
#19
Defang Gan, Mengdan Zhan, Feng Yang, Qiqi Zhang, Keling Hu, Wenjuan Xu, Qinghui Lu, Ling Zhang, Dandi Liang
Posttranscriptional control of gene expression can be achieved through RNA interference when the activities of Dicer-like (DCL), argonaute (AGO) and RNA-dependent RNA polymerase (RDR) proteins are significant. In this study, we analysed the expression of seven AGO, five DCL and eight RDR genes in cucumber under cold, heat, hormone, salinity and dehydration treatments using quantitative reverse-transcription PCR (qRT-PCR). All CsAGO, CsDCL and CsRDR genes were differentially expressed under abiotic stress treatment...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28672899/pathway-related-modules-involved-in-the-application-of-sevoflurane-or-propofol-in-off-pump-coronary-artery-bypass-graft-surgery
#20
Xiangmei Bu, Bo Wang, Yaoqi Wang, Zhigang Wang, Chunzhi Gong, Feng Qi, Caixia Zhang
Off-pump coronary artery bypass graft (CABG) surgery has recently emerged as a means to avoid the sequelae of extracorporeal circulation, including the whole-body inflammatory response, coagulation disorders and multiple organ dysfunction. At present, gas anesthesia, sevoflurane and intravenous anesthesia and propofol have been widely used during the CABG. To further understand the underlying mechanisms of these anesthetics on the gene level, the present study conducted pathway-related module analysis based on a co-expression network...
July 2017: Experimental and Therapeutic Medicine
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