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"Feng Zhang"

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https://www.readbyqxmd.com/read/29352123/tumor-tissue-detection-using-blood-oxygen-level-dependent-functional-mri-based-on-independent-component-analysis
#1
Huiyuan Huang, Junfeng Lu, Jinsong Wu, Zhongxiang Ding, Shuda Chen, Lisha Duan, Jianling Cui, Fuyong Chen, Dezhi Kang, Le Qi, Wusi Qiu, Seong-Whan Lee, ShiJun Qiu, Dinggang Shen, Yu-Feng Zang, Han Zhang
Accurate delineation of gliomas from the surrounding normal brain areas helps maximize tumor resection and improves outcome. Blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) has been routinely adopted for presurgical mapping of the surrounding functional areas. For completely utilizing such imaging data, here we show the feasibility of using presurgical fMRI for tumor delineation. In particular, we introduce a novel method dedicated to tumor detection based on independent component analysis (ICA) of resting-state fMRI (rs-fMRI) with automatic tumor component identification...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351796/the-jun-mir-22-hur-regulatory-axis-contributes-to-tumourigenesis-in-colorectal-cancer
#2
Yanqing Liu, Xiaorui Chen, Rongjie Cheng, Fei Yang, Mengchao Yu, Chen Wang, Shufang Cui, Yeting Hong, Hongwei Liang, Minghui Liu, Chihao Zhao, Meng Ding, Wu Sun, Zhijian Liu, Feng Sun, Chenyu Zhang, Zhen Zhou, Xiaohong Jiang, Xi Chen
BACKGROUND: Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention. Hu antigen R (HuR), which is highly upregulated in CRC, functions as a pivotal oncogene to promote CRC progression. However, the underlying cause of its dysregulation is poorly understood. METHODS: In CRC tissue sample pairs, HuR protein levels were measured by Western blot and immunohistochemical (IHC) staining, respectively...
January 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29350589/epidemiological-investigation-and-genotype-of-chlamydia-exposure-in-pigeons-in-three-provinces-in-northern-china
#3
Xin Wang, Nian-Zhang Zhang, Chun-Feng Ma, Xiao-Xuan Zhang, Quan Zhao, Hong-Bo Ni
Chlamydia is considered as one of the most widely prevalent zoonotic pathogens. It can spread from infected birds to human beings through direct or indirect contact with fecal shedding of Chlamydia. However, data concerning prevalence and genotypes of Chlamydia in pigeons are limited. In the present study, a total of 963 serum samples was collected from Jilin Province, Liaoning Province, and Inner Mongolia Autonomous Region (IMAR) in China between August 2015 and December 2016 and the seroprevalence for Chlamydia was analyzed by indirect hemagglutination assay test...
January 19, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29349970/-total-thigh-musculocutaneous-flap-in-reconstruction-of-refractory-pressure-ulcers-around-hips-in-patients-with-spinal-cord-injury
#4
Li-Feng Zhai, Li-Feng Shen, Gou-Ping Ma, Qiao-Feng Guo, Chun Zhang
OBJECTIVE: To discuss the treatment of life-threatening refractory pressure ulcers around hips in patients with spinal cord injuries(SCI)and evaluate its clinical outcomes. METHODS: From March 2012 to June 2015, eight paraplegic patients with life-threatening refractory pressure ulcers around hips were treated with total thigh musculocutaneous flaps following amputation of proximal femurs or hips, including 7 males and 1 female with an average age of (52.0±2.6) years old ranging from 35 to 68...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29346707/tuning-high-temperature-wetting-behavior-of-metal-toward-ultrafine-nanoparticles
#5
Yubing Zhou, Bharath Natarajan, Yanchen Fan, Hua Xie, Chunpeng Yang, Shaomao Xu, Yonggang Yao, Feng Jiang, Qianfan Zhang, Jeffrey W Gilman, Liangbing Hu
The interaction between the metal nanoparticles and their substrate plays a critical role in determining the particle morphology, distribution, and properties. Here we present the pronounced impact of a thin oxide coating to the dispersion of metal nanoparticles on a carbon matrix. We employ Al2O3-supported Pt nanoparticles in comparison with direct synthesis of Pt nanoparticles on bare carbon surfaces. Pt nanoparticles with an average size of ≈2 nm and a size distribution ranging between 0.5 nm and 4.0 nm are synthesized on the Al2O3 coated carbon nanofiber, significantly improved compared to those directly synthesized on bare carbon surface...
January 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29344418/advances-in-the-studies-of-ginkgo-biloba-leaves-extract-on-aging-related-diseases
#6
REVIEW
Wei Zuo, Feng Yan, Bo Zhang, Jiantao Li, Dan Mei
The prevalence of degenerative disorders in public health has promoted in-depth investigations of the underlying pathogenesis and the development of new treatment drugs. Ginkgo biloba leaves extract (EGb) is obtained from Ginkgo biloba leaves and has been used for thousands of years. In recent decades, both basic and clinical studies have established the effects of EGb. It is widely used in various degenerative diseases such as cerebrovascular disease, Alzheimer's disease, macroangiopathy and more. Here, we reviewed several pharmacological mechanisms of EGb, including its antioxidant properties, prevention of mitochondrial dysfunctions, and effect on apoptosis...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29339208/targeted-shrna-loaded-liposome-complex-combined-with-focused-ultrasound-for-blood-brain-barrier-disruption-and-suppressing-glioma-growth
#7
Guanjian Zhao, Qin Huang, Feng Wang, Xiang Zhang, Jiangang Hu, Ying Tan, Ning Huang, Zhigang Wang, Zhibiao Wang, Yuan Cheng
Our previous studies have demonstrated that focused ultrasound (FUS) combined with DNA-loaded microbubbles (MBs) can induce noninvasive, reversible, local disruption of the blood brain barrier (BBB) and enable targeted exogenous gene transfer into the central nervous system. However, due to low gene loading or the absence of positive targeting, to date, there has been no therapeutic effect of MBs combined with FUS in tumor treatment. In the current study, we adopted a phospholipid complex that exhibited sufficient gene loading and peptide-mediated targeting to delay glioma growth...
January 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29336513/palladium-catalyzed-asymmetric-aminohydroxylation-of-1-3-dienes
#8
Liuzhu Gong, Hong-Cheng Shen, Yu-Feng Wu, Ying Zhang, Lian-Feng Fan, Zhi-Yong Han
A Pd(II)-catalyzed asymmetric aminohydroxylation of 1,3-dienes with N-tosyl-2-aminophenols has been developed with a chiral pyridinebis(oxazoline) ligand. The highly regioselective reaction provides a direct and efficient approach to access chiral 3,4-dihydro-2H-1,4-benzoxazines in high levels of yield and enantioselectivity (up to 96:4 e.r.). The reaction employs readily available N-tosyl-2-aminophenols as a unique aminohydroxylation reagent complementary to known asymmetric aminohydroxylation methods.
January 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29331977/clinical-outcomes-and-prognostic-factors-in-patients-with-spinal-dural-arteriovenous-fistulas-a-prospective-cohort-study-in-two-chinese-centres
#9
Yongjie Ma, Sichang Chen, Chao Peng, Chunxiu Wang, Guilin Li, Chuan He, Ming Ye, Tao Hong, Lisong Bian, Jiang Liu, Zhichao Wang, Adnan I Qureshi, Feng Ling, Hongqi Zhang
BACKGROUND: The short-term outcomes and prognostic factors of patients with spinal dural arteriovenous fistulas (SDAVFs) have not been defined in large cohorts. OBJECTIVE: To define the short-term clinical outcomes and prognostic factors in patients with SDAVFs. METHODS: A prospective cohort of 112 patients with SDAVFs were included consecutively in this study. The patients were serially evaluated with the modified Aminoff and Logue's Scale (mALS) one day before surgery and at 3 months, 6 months and 12 months after treatment...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331027/mir-137-functions-as-a-tumor-suppressor-in-pancreatic-cancer-by-targeting-mrgbp
#10
Feng Ding, Shuang Zhang, Shaoyang Gao, Jian Shang, Yanxia Li, Ning Cui, Qiu Zhao
miRNAs are small noncoding RNAs that act as critical epigenetic regulators in tumor carcinogenesis. In this study, our data showed that miR-137 was significantly downregulated in 58 pairs of human pancreatic cancer (PanCa) tissues and PanCa cell lines. Furthermore, the deregulated miR-137 was correlated with increased tumor size, higher TNM stage, and worse prognosis in pancreatic cancer. Functional studies demonstrated that overexpression of miR-137 dramatically suppressed cell proliferation and induced cell apoptosis in vitro...
January 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29329645/polysaccharides-extracted-from-the-roots-of-bupleurum-chinense-dc-modulates-macrophage-functions
#11
Zhi-De Zhang, Hong Li, Fen Wan, Xiao-Yu Su, Yan Lu, Dao-Feng Chen, Yun-Yi Zhang
The present study aimed to investigate the effects of polysaccharides extracted from Bupleurum chinense DC (BCPs) on macrophage functions. In the in vivo experiment, 1 mL of 5% sodium thioglycollate was injected into the abdomen of the mice on Day 0 and macrophages were harvested on Day 4. The macrophages were cultured in plates and treated with different concentrations of BCPs and stimulus. Effects of BCPs on macrophage functions were assessed by chemotaxis assay, phagocytosis assay and Enzyme-Linked Immunosorbent Assay (ELISA)...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329613/new-diterpenoids-isolated-from-leonurus-japonicus-and-their-acetylcholinesterase-inhibitory-activity
#12
Han-Kui Wu, Ting Sun, Feng Zhao, Li-Ping Zhang, Gang Li, Jie Zhang
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1D and 2D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329368/discovering-personalized-driver-mutation-profiles-of-single-samples-in-cancer-by-network-control-strategy
#13
Wei-Feng Guo, Shao-Wu Zhang, Li-Li Liu, Fei Liu, Qian-Qian Shi, Lei Zhang, Ying Tang, Tao Zeng, Luonan Chen
Motivation: It is a challenging task to discover personalized driver genes that provide crucial information on disease risk and drug sensitivity for individual patients. However, few methods have been proposed to identify the personalized-sample driver genes from the cancer omics data due to the lack of samples for each individual. To circumvent this problem, here we present a novel single-sample controller strategy (SCS) to identify personalized driver mutation profiles from network controllability perspective...
January 10, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29328445/the-effects-of-interleukin-2-and-rad-p53-as-a-treatment-for-glioblastoma
#14
Hai-Bo Qiao, Jia Li, Lian-Jie Lv, Ben-Jin Nie, Peng Lu, Feng Xue, Zhi-Ming Zhang
Interleukin 2 (IL-2) is an anti-cancer cytokine that stimulates T cell propagation, triggering innate and adaptive immunity. IL-2 has been used for cancer therapy and has achieved curative effects. Recombinant adenovirus p53 injection (rAd‑p53) is a gene therapeutic agent that may improve the prognosis of patients with glioblastoma (GBM). In the present study, the effect of combined IL‑2 and rAd‑p53 treatment was studied. The ability of IL‑2 to stimulate immunoregulation and the ability of p53 to induce apoptosis for GBM was researched in the GBM tumor model...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328441/ubenimex-an-apn-inhibitor-could-serve-as-an-anti%C3%A2-tumor-drug-in-rt112-and-5637-cells-by-operating-in-an-akt%C3%A2-associated-manner
#15
Xiaoqing Wang, Yang Liu, Wei Liu, Yongfei Zhang, Feng Guo, Lijuan Zhang, Mingyu Cui, Shuai Liu, Rongde Wu
Bladder cancer, a common urinary tract tumor, has high mortality and recurrence rates associated with metastasis. Aminopeptidase N (APN) expression and metastasis have been indicated to be associated with one another. Ubenimex may function as an APN inhibitor to inhibit the degradation of the extracellular matrix during tumorigenesis. Furthermore, APN has been widely used as an adjuvant therapy for the treatment of tumors; however, little information is available regarding the impact of ubenimex on patients...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29324846/correction-hydrogen-sulfide-alleviates-postharvest-ripening-and-senescence-of-banana-by-antagonizing-the-effect-of-ethylene
#16
Yun Ge, Kang-Di Hu, Sha-Sha Wang, Lan-Ying Hu, Xiao-Yan Chen, Yan-Hong Li, Ying Yang, Feng Yang, Hua Zhang
[This corrects the article DOI: 10.1371/journal.pone.0180113.].
2018: PloS One
https://www.readbyqxmd.com/read/29316673/transcriptome-analysis-in-haematococcus-pluvialis-astaxanthin-induction-by-high-light-with-acetate-and-fe2
#17
Bangxiang He, Lulu Hou, Manman Dong, Jiawei Shi, Xiaoyun Huang, Yating Ding, Xiaomei Cong, Feng Zhang, Xuecheng Zhang, Xiaonan Zang
Haematococcus pluvialis is a commercial microalga, that produces abundant levels of astaxanthin under stress conditions. Acetate and Fe2+ are reported to be important for astaxanthin accumulation in H. pluvialis. In order to study the synergistic effects of high light stress and these two factors, we obtained transcriptomes for four groups: high light irradiation (HL), addition of 25 mM acetate under high light (HA), addition of 20 μM Fe2+ under high light (HF) and normal green growing cells (HG). Among the total clean reads of the four groups, 156,992 unigenes were found, of which 48...
January 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29304491/influences-of-different-dietary-energy-level-on-sheep-testicular-development-associated-with-ampk-ulk1-autophagy-pathway
#18
Jing Pang, Fengzhe Li, Xu Feng, Hua Yang, Le Han, Yixuan Fan, Haitao Nie, Zhen Wang, Feng Wang, Yanli Zhang
Energy balance is an important feature for spermatozoa production in the testis. The 5'-AMP-activated protein kinase (AMPK) is a sensor of cell energy, has been implicated as a mediator between gonadal function and energy balance. Herein, we intended to determine the physiological effects of AMPK on testicular development in feed energy restricted and compensated pre-pubertal rams. Lambs had restricted feeding for 2 months and then provided compensatory feeding for another 3 months. Feed levels were 100%(control), 15% and 30% of energy restriction (ER) diets, respectively...
December 14, 2017: Theriogenology
https://www.readbyqxmd.com/read/29303852/interpositional-arthroplasty-by-temporalis-fascia-flap-and-galea-aponeurotica-combined-with-distraction-osteogenesis-a-modified-method-in-treatment-of-adult-patients-with-temporomandibular-joint-ankylosis-and-mandibular-dysplasia
#19
Jia Qiao, Bing Yu, Lai Gui, Xi Fu, Chung-Kwan Yen, Feng Niu, Huijun Zhang, Cai Wang, Ying Chen, Meng Wang, Jianfeng Liu
BACKGROUND: Interpositional arthroplasty (IPA) with temporalis fascia flap has been one of the most frequently performed procedures to treat temporomandibular joint (TMJ) ankylosis. However, recurrence often occurs when the flap lacks bulk or atrophies. Whether to perform IPA or distraction osteogenesis (DO) first has long been a controversial issue when patients presented mandibular dysplasia (MD). This study provided IPA a new graft material sufficient to prevent recurrence, combined the modified protocol of performing DO 6 months after IPA, and evaluated its efficacy in treating TMJ ankylosis patients with MD...
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29303205/transition-metal-catalyst-free-synthesis-of-anthranilic-acid-derivatives-by-transfer-hydrogenative-coupling-of-2-nitroaryl-methanols-with-alcohols-amines
#20
Shudi Zhang, Zhenda Tan, Biao Xiong, Huan Feng Jiang, Min Zhang
By using a transfer hydrogenative coupling strategy, we herein describe a new method for the efficient synthesis of anthranilic acid derivatives, a significantly important class of compounds with extensive applications in organic synthesis and the discovery of bioactive molecules, from 2-nitroaryl methanols and readily available alcohols/amines. The synthesis proceeds with the merits of no need for a transition metal catalyst, operational simplicity, broad substrate scope, good functional tolerance, and high step efficiency, which offers a useful alternative to access anthranilic acid derivatives...
January 5, 2018: Organic & Biomolecular Chemistry
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