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https://www.readbyqxmd.com/read/29793131/tlr2-4-ligand-amplified-liver-inflammation-promotes-initiation-of-autoimmune-hepatitis-due-to-sustained-il-6-il-12-il-4-il-25-expression
#1
Gang Chi, Xin-Xia Feng, Ying-Xia Ru, Ting Xiong, Yuan Gao, Han Wang, Zhen-Long Luo, Ran Mo, Fang Guo, Yong-Pei He, Gui-Mei Zhang, De-An Tian, Zuo-Hua Feng
Autoimmune hepatitis (AIH), a serious autoimmune liver disease, can be a lifelong illness, leading to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). So far the mechanisms for disease initiation are largely unknown. Here we report that the amplified non-AIH liver inflammation could promote the initiation of AIH due to the sustained increase of IL-6, IL-12, IL-4, and IL-25 in the liver. The liver injury resulting from virus (adenovirus) or chemicals (CCl4 ) could induce an amplified (stronger/long-lasting) hepatic inflammation by releasing the ligands for TLR2/TLR4...
May 21, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29793070/intradialytic-blood-pressure-pattern-recognition-based-on-density-peak-clustering
#2
Feng Wang, Jing-Yi Zhou, Yu Tian, Yu Wang, Ping Zhang, Jiang-Hua Chen, Jing-Song Li
End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD) and requires hemodialysis (HD) for survival. Intradialytic blood pressure (IBP) measurements are necessary to ensure patient safety during HD treatments and have critical clinical and prognostic significance. Studies on IBP measurements, especially IBP patterns, are limited. All related studies have been based on a priori knowledge and artificially classified IBP patterns. Therefore, the results were influenced by subjective concepts...
May 21, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29792906/four-novel-antibacterial-sesquiterpene-%C3%AE-amino-acid-quaternary-ammonium-hybrids-from-the-mycelium-of-mushroom-stereum-hirsutum
#3
Yuan-Chang Duan, Jun Feng, Na Bai, Guo-Hong Li, Ke-Qin Zhang, Pei-Ji Zhao
The mushroom Stereum hirsutum is parasitized by Tremella aurantia to form a heterogeneous basidiocarp Jin'er, which has been used as food and folk medicine in Chinese society. In present work, the S. hirsutum was fermented in YMG broth, and four novel mixed terpenes, stereumamides A-D (1-4), which are sesquiterpenes combined with α-amino acids to form quaternary ammonium hybrids, were isolated from the Stereum hirsutum FP-91666 and their structures were elucidated by spectroscopic data analysis. Stereumamides A and D showed antibacterial activity against Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium, with the minimum inhibitory concentration (MIC) values of 12...
May 21, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29792597/increasing-plant-diversity-with-border-crops-reduces-insecticide-use-and-increases-crop-yield-in-urban-agriculture
#4
Nian-Feng Wan, You-Ming Cai, Yan-Jun Shen, Xiang-Yun Ji, Xiang-Wen Wu, Xiang-Rong Zheng, Wei Cheng, Jun Li, Yao-Pei Jiang, Xin Chen, Jacob Weiner, Jie-Xian Jiang, Ming Nie, Rui-Ting Ju, Tao Yuan, Jian-Jun Tang, Wei-Dong Tian, Hao Zhang, Bo Li
Urban agriculture is making an increasing contribution to food security in large cities around the world. The potential contribution of biodiversity to ecological intensification in urban agricultural systems has not been investigated. We present monitoring data collected from rice fields in 34 community farms in mega-urban Shanghai, China, from 2001 to 2015, and show that the presence of a border crop of soybeans and neighboring crops (maize, eggplant and Chinese cabbage), both without weed control, increased invertebrate predator abundance, decreased the abundance of pests and dependence on insecticides, and increased grain yield and economic profits...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29791469/ffuzz-towards-full-system-high-coverage-fuzz-testing-on-binary-executables
#5
Bin Zhang, Jiaxi Ye, Xing Bi, Chao Feng, Chaojing Tang
Bugs and vulnerabilities in binary executables threaten cyber security. Current discovery methods, like fuzz testing, symbolic execution and manual analysis, both have advantages and disadvantages when exercising the deeper code area in binary executables to find more bugs. In this paper, we designed and implemented a hybrid automatic bug finding tool-Ffuzz-on top of fuzz testing and selective symbolic execution. It targets full system software stack testing including both the user space and kernel space. Combining these two mainstream techniques enables us to achieve higher coverage and avoid getting stuck both in fuzz testing and symbolic execution...
2018: PloS One
https://www.readbyqxmd.com/read/29791209/binding-of-intercellular-adhesion-molecule-1-to-%C3%AE-2-integrin-regulates-distinct-cell-adhesion-on-hepatic-and-cerebral-endothelium
#6
Chun-Fang Tong, Yan Zhang, Shou-Qin Lü, Ning Li, Yi-Xin Gong, Hao Yang, Shi-Liang Feng, Yu Du, Dan-Dan Huang, Mian Long
Flowing neutrophils (PMNs) are forced to recruit towards inflamed tissue and adhere on vascular endothelial cells, which is primarily mediated by the binding of β2 -integrins to ICAM-1s. This process is distinct among different organs such as liver and brain, however, the underlying kinetic and mechanical mechanisms regulating tissue-specific recruitment of PMNs remain unclear. Here binding kinetics measurement showed that, ICAM-1 on murine hepatic sinusoidal endothelial cells (LSECs) bound to lymphocyte function-associated antigen-1 (LFA-1) with higher on- and off-rates but lower effective affinity compared to macrophage-1 antigen (Mac-1), while ICAM-1 on cerebral endothelial cells (BMECs or bEnd...
May 23, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29791067/synergistic-catalysis-enabled-reaction-of-2-indolymethanols-with-oxonium-ylides-construction-of-3-indolyl-3-alkoxy-oxindole-framework
#7
Chun Ma, Jia-Yu Zhou, Yi-Zhu Zhang, Yin-Chun Jiao, Guang-Jian Mei, Feng Shi
A synergistic catalysis-enabled reaction of 2-indolymethanols with oxonium ylides has been established, which makes use of the three-component reaction of 3-diazooxindoles, alcohols and 2-indolymethanols under the cooperative catalysis of metal complex and Brønsted acid. This reaction has not only provided a new approach for constructing 3-indolyl-3-alkoxy oxindole scaffolds by utilizing the indole C3-electrophilicity, but also realized a nucleophilic addition of metal associated ylide to 2-indolylmethanols for the first time...
May 23, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29790980/contrasting-patterns-of-genomic-diversity-reveal-accelerated-genetic-drift-but-reduced-directional-selection-on-x-chromosome-in-wild-and-domestic-sheep-species
#8
Ze-Hui Chen, Min Zhang, Feng-Hua Lv, Xue Ren, Wen-Rong Li, Ming-Jun Liu, Kiwoong Nam, Michael W Bruford, Meng-Hua Li
Analyses of genomic diversity along the X chromosome and of its correlation with autosomal diversity can facilitate understanding of evolutionary forces in shaping sex-linked genomic architecture. Strong selective sweeps and accelerated genetic drift on the X-chromosome have been inferred in primates and other model species, but no such insight has yet been gained in domestic animals compared with their wild relatives. Here, we analyzed X-chromosome variability in a large ovine data set, including a BeadChip array for 943 ewes from the world's sheep populations and 110 whole genomes of wild and domestic sheep...
April 1, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29790898/ezh2-induces-the-expression-of-mir-1301-as-a-negative-feedback-control-mechanism-in-triple-negative-breast-cancer
#9
Qiuju Wu, Zekun Chen, Guihua Zhang, Wenhui Zhou, You Peng, Rong Liu, Ceshi Chen, Jing Feng
Breast cancer is one of the most common malignancies in women. ERα, PR, and HER2 triple negative breast cancer (TNBC) is the current research focus because of the lack of effective targeted therapies. In our study, lentivirus systems were used to overexpress EZH2 and miR-1301 in TNBC cell lines. Western blot analysis and RT-qPCR were used to detect the protein and microRNA levels. The TCGA and Kaplan Meier plotter databases were used to analyze the EZH2 and miR-1301 expression levels in breast cancer. The effect of miR-1301 overexpression on cell proliferation, migration and colony formation were determined by using the sulforhodamine B (SRB) assay, wound healing assay and colony formation assay, respectively...
May 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29790821/effects-of-immuno-related-gene-polymorphisms-on-a-bispecific-antibody-targeting-colorectal-cancer-cell
#10
Cong-Min Zhang, Lin-Yu Yu, Jin-Feng Lv, Liang Gong, Hong-Hao Zhou, Xiao-Ping Chen, Lan Fan
BACKGROUND: Colorectal cancer (CRC) represents the third most common type of cancer and the third leading cause of death from cancer around the world. M701 is a CD3/EpCAM bispecific antibody that shows promising cytotoxicity toward CRC cells. AIM: To investigate the influence of immuno-related gene polymorphisms on M701 mediated cytotoxicity to CRC cell HCT116. METHOD: We analyzed the influence of the effect of M701 on the activation and cytotoxicity of peripheral mononuclear blood cells from 129 healthy volunteers with different genotypes...
May 23, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29790797/curcumin-loaded-redox-responsive-mesoporous-silica-nanoparticles-for-targeted-breast-cancer-therapy
#11
Nana Li, Zhi Wang, Yongtai Zhang, Kai Zhang, Jianxu Xie, Ying Liu, Wansi Li, Nianping Feng
HYPOTHESIS: The antitumor applications of curcumin (CUR) are limited because of its low water solubility, poor stability, and low bioavailability. We developed novel nanocarrier systems for tumour targeting and controlled CUR release and evaluated their therapeutic efficacy. EXPERIMENTS: The surface of mesoporous silica nanoparticles (MSN) was modified with hyaluronan (HA) or polyethyleneimine-folic acid (PEI-FA) via disulfide bonds. The capacity of the resultant nanocarriers (MSN-HA and MSN-PEI-FA, respectively) for CUR delivery was evaluated in a breast cancer cell line and a mouse xenograft model...
May 23, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29790644/crispr-cas9-assisted-multiplex-genome-editing-technique-in-escherichia-coli
#12
Xu Feng, Dongdong Zhao, Xueli Zhang, Xiang Ding, Changhao Bi
Genome editing for site-specific chromosome modification is one of the most significant techniques in biological research. While conventional techniques usually deal with one genomic locus at a time, multiple genomic targets are often required to be modified to develop microbial cell factories. Thus, it is necessary to develop techniques for simultaneous editing of multiple loci. In this work, we developed a CRISPR/Cas9 assisted multiplex genome editing (CMGE) technique in Escherichia coli. With this editing method, all functional parts were assembled into replicable plasmids, and stringent inducible expression systems were used to control Cas9 gene expression, which was to decouple transformation from editing process to increase editing efficiency...
May 23, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29790616/in-vitro-and-in-vivo-metabolic-profiles-of-fasiglifam-by-using-ultra-high-performance-liquid-chromatography-combined-with-q-exactive-orbitrap-tandem-mass-spectrometry
#13
Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She
RATIONALE: Fasiglifam is an orally available and selective partial agonist of hGPR40 receptor, which was unexpectedly terminated at phase III clinical trials due to its severe hepatotoxicity. To fully understand its mechanism of action, it is necessary to investigate the in vitro and in vivo metabolic profiles of fasiglifam. METHODS: For in vitro metabolism, fasiglifam was incubated with rat or human liver microsomes in the presence of NADPH, GSH and UDPGA for 60 min...
May 23, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29790062/analysis-of-pulse-signals-based-on-array-pulse-volume
#14
Ji Cui, Li-Ping Tu, Jian-Feng Zhang, Shao-Liang Zhang, Zhi-Feng Zhang, Jia-Tuo Xu
OBJECTIVE: To collect and analyze multi-dimensional pulse diagram features with the array sensor of a pressure profile system (PPS) and study the characteristic parameters of the new multi-dimensional pulse diagram by pulse diagram analysis technology. METHODS: The pulse signals at the Guan position of left wrist were acquired from 105 volunteers at the Shanghai University of Traditional Chinese Medicine. We obtained the pulse data using an array sensor with 3×4 channels...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29789882/rapid-development-of-stable-transgene-cho-cell-lines-by-crispr-cas9-mediated-site-specific-integration-into-c12orf35
#15
Menglin Zhao, Jiaxian Wang, Manyu Luo, Han Luo, Meiqi Zhao, Lei Han, Mengxiao Zhang, Hui Yang, Yueqing Xie, Hua Jiang, Lei Feng, Huili Lu, Jianwei Zhu
Chinese hamster ovary (CHO) cells are the most widely used mammalian hosts for recombinant protein production. However, by conventional random integration strategy, development of a high-expressing and stable recombinant CHO cell line has always been a difficult task due to the heterogenic insertion and its caused requirement of multiple rounds of selection. Site-specific integration of transgenes into CHO hot spots is an ideal strategy to overcome these challenges since it can generate isogenic cell lines with consistent productivity and stability...
May 22, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29789854/theoretical-study-on-the-optical-and-electronic-properties-of-graphene-quantum-dots-doped-with-heteroatoms
#16
Jianguang Feng, Hongzhou Dong, Beili Pang, Feifei Shao, ChunKai Zhang, Liyan Yu, Lifeng Dong
The effects of four heteroatoms (B, N, P, and S) with three doping patterns on graphene quantum dots (GQDs) are systematically investigated using time-dependent density functional theory (TD-DFT). The absorption spectra and HOMO-LUMO gaps are quantitatively analyzed to study the correlations between the optical properties and heteroatom doping of doped GQDs. Heteroatom doping can endow GQDs with various new optical and structural properties, depending on the dopants and doping configurations. Compared with the absorption spectra of pristine GQD, both N and S surface doping demonstrate a slight blue shift, whereas B and P doping lead to a blue shift for edge-doped GQDs with heteroatoms in a pentatomic ring...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29789525/fertilization-shapes-a-well-organized-community-of-bacterial-decomposers-for-accelerated-paddy-straw-degradation
#17
Yushan Zhan, Wenjing Liu, Yuanyuan Bao, Jianwei Zhang, Evangelos Petropoulos, Zhongpei Li, Xiangui Lin, Youzhi Feng
Straw, mainly dry stalks of crops, is an agricultural byproduct. Its incorporation to soils via microbial redistribution is an environment-friendly way to increase fertility. Fertilization influences soil microorganisms and straw degradation. However, our up to date knowledge on the responses of the straw decomposers to fertilization remains elusive. To this end, inoculated with paddy soils with 26-year applications of chemical fertilizers, organic amendments or controls without fertilization, microcosms were anoxically incubated with 13 C-labelled rice straw amendment...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789365/structural-alteration-of-gut-microbiota-during-the-amelioration-of-human-type-2-diabetes-with-hyperlipidemia-by-metformin-and-a-traditional-chinese-herbal-formula-a-multicenter-randomized-open-label-clinical-trial
#18
Xiaolin Tong, Jia Xu, Fengmei Lian, Xiaotong Yu, Yufeng Zhao, Lipeng Xu, Menghui Zhang, Xiyan Zhao, Jian Shen, Shengping Wu, Xiaoyan Pang, Jiaxing Tian, Chenhong Zhang, Qiang Zhou, Linhua Wang, Bing Pang, Feng Chen, Zhiping Peng, Jing Wang, Zhong Zhen, Chao Fang, Min Li, Limei Chen, Liping Zhao
Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested the hypothesis that alteration of gut microbiota may be involved in the alleviation of T2DM with hyperlipidemia by metformin and a specifically designed herbal formula (AMC). Four hundred fifty patients with T2DM and hyperlipidemia were randomly assigned to either the metformin- or AMC-treated group. After 12 weeks of treatment, 100 patients were randomly selected from each group and assessed for clinical improvement...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29789216/the-clinical-presentation-and-collateral-pathway-development-of-congenital-absence-of-the-internal-carotid-artery
#19
Peng Zhang, Zheng Wang, Feng-Xia Yu, Han Lv, Xue-Huan Liu, Wei-Hua Feng, Jun Ma, Zheng-Han Yang, Zhen-Chang Wang
OBJECTIVE: The objective of this study was to investigate the clinical presentation, risks, and collateral pathway development of the congenital absence of the internal carotid artery (ICA). METHODS: Sixty-four patients (10 new patients and 54 patients from the relevant literature) were studied. Data on demographic, clinical, and radiologic features were collected, followed by an analysis of the risks associated with ICA agenesis. RESULTS: There were 31 male and 33 female patients whose ages ranged from 5 months to 75 years, with a mean age of 31...
May 19, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29789104/functionalized-caprolactone-polyethylene-glycol-based-thermo-responsive-hydrogels-of-silibinin-for-the-treatment-of-malignant-melanoma
#20
Behzad Sharif Makhmalzadeh, Ommoleila Molavi, Mohammad Reza Vakili, Hai-Feng Zhang, Amir Solimani, Hoda Soleymani Abyaneh, Raimar Loebenberg, Raymond Lai, Afsaneh Lavasanifar
PURPOSE: Silibinin, is a natural compound, which has shown anticancer activity in various malignancies. In this study, we evaluated the anticancer effects of silibinin in B16-F10 melanoma cells and developed a novel thermoresponsive hydrogel for local delivery of this compound. METHOD: A thermoresponsive hydrogel loaded with silibinin was prepared using triblock copolymers of poly[(α-benzyl carboxylate-e-caprolactone)-co-(α-carboxyl-e-caprolactone)]ran-b-PEG-b-[(α-benzyl carboxylate-e-caprolactone) -co-(α-carboxyl-e-caprolactone)]ran (PCBCL-b-PEG-b-PCBCL), namely PolyGelTM, and compared with a Pluronic F-127 formulation of silibinin...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
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