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Feng zhang

R L Zhang, X H Zheng, L K Zhou, Y Zhang, S L Chen, D L Yang, E L Jiang, J L Wei, Y Huang, Q L Ma, W H Zhai, S Z Feng, M Z Han, Y He
Objective: To investigate the effects of donor-specific HLA antibodies(DSA) for graft failure in un-manipulated haploidentical hematopoietic stem cell transplantation(haplo-HSCT) and the feasible treatment for DSA. Methods: HLA antibodies were examined using the Luminex-based single Ag assay for 92 patients who were going on haplo-SCT and the correlations of graft failure and DSA among the patients who had finished SCT were analyzed. Results: Of the total 92 patients who were going on haplo-HSCT, sixteen (17...
March 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
M Chen, J L Zhuang, M H Duan, W Zhang, J Li, T N Zhu, H C Cai, X X Cao, J Feng, C Yang, Y Zhang, L Zhang, D B Zhou, B Han
Objective: To Evaluate the efficacy and safety of posaconazole as primary prevention of invasive fungal disease (IFD) in patients with severe aplastic anemia (SAA) treated with anti-thymus/lymphocyte immunoglobulin (ATG/ALG) combined with cyclosporine intensive immunosuppressive therapy (IST). Methods: A retrospective analysis of clinical data of 58 SAA patients who received IST of anti-thymocyte immunoglobulin combining cyclosporine and antifungal prophylaxis during April 2013 to May 2017 in Peking Union Medical College Hospital was performed...
February 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
X J Wang, J H Feng, M H Zhang, X M Li, D D Ma, S S Chang
The intestinal microbiome has been shown to influence animal nutrient metabolism and immune homeostasis. The present study aimed to examine the effect of heat stress on the intestinal microbiome of broilers using pyrosequencing technologies. Ninety-six Arbor Acres broiler chicks were allocated to thermoneutral control (TC; 21 ± 1°C) and high ambient temperature (HT; 31 ± 1°C) groups (6 cages of 8 birds per group), respectively, and raised in 2 controlled climate chambers from 28 to 42 d old. Genomic DNA was extracted from ileal contents isolated from 6 male broiler chicks of each group at 42 d old, and then amplified based on the V3-4 hyper-variable region of 16S rRNA...
March 16, 2018: Poultry Science
Wei Zhang, Guihai Feng, Libin Wang, Fei Teng, Liu Wang, Wei Li, Ying Zhang, Qi Zhou
The generation of induced pluripotent stem cells (iPSCs) offers a great opportunity in research and regenerative medicine. The current poor efficiency and incomplete mechanistic understanding of the reprogramming process hampers the clinical application of iPSCs. MeCP2 connects histone modification and DNA methylation, which are key changes of somatic cell reprogramming. However, the role of MeCP2 in cell reprogramming has not been examined. In this study, we found that MeCP2 deficiency enhanced reprogramming efficiency and stimulated cell proliferation through regulating cell cycle protein expression in the early stage of reprogramming...
March 19, 2018: Journal of Molecular Cell Biology
Jian Zheng, Wei Zhang, Feng Wang, Xiao-Ying Yu
In this present paper, a vacuum compatible microfluidic device, System for Analysis at the Liquid Vacuum Interface (SALVI), is integrated to hard X-ray absorption spectroscopy (XAS) to obtain the local structure of K3[Fe(CN)6] in aqueous solutions with three concentrations of 0.5 M, 0.05 M, and 0.005 M. The solutions were sealed in a microchannel of 500 μm wide and 300 µm deep in a portable microfluidic device. The Fe K-edge X-ray absorption spectra indicates presence of Fe(III) in the complex in water, with an octahedral geometry coordinated with 6 C atoms in the first shell with a distance of ~1...
March 21, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Zhuoyue Chen, Zhen Zhang, Juantao Feng, Yayuan Guo, Yuan Yu, Jihong Cui, Hongmin Li, Lijun Shang
One of the key challenges in bone healing and regeneration is the implant with osteoinductive activity. Therapeutic application of recombinant human bone morphogenetic protein-2 (rhBMP-2) is a promising approach to enhance osteogenesis. However, high dose and uncontrolled burst in the release kinetics of BMP-2 may introduce oedema, bone overgrowth, cyst-like bone formation and significant inflammation. In this study, low dose BMP-2 of 1µg was used to design PLA-PD-BMP for functionalization of polylactic acid (PLA) implants via mussel-inspired polydopamine (PD) assist...
March 21, 2018: ACS Applied Materials & Interfaces
Zhao-Fei Zhang, He Huang, Shuai Chen, Dong-Hua Liu, Yong-Hui Feng, Chun-Liang Xie, Feng Jiao
BACKGROUND: High-viscosity cement (HVC) has been gradually applied in percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). Although HVC has been reported to reduce cement leakage, different opinions exist. To assess the complications of HVC in cement leakage in the treatment of vertebral compression fractures and to evaluate the clinical effect of HVC compared with low-viscosity cement (LVC). METHODS: EMBASE, PubMed, Science Direct, Google Scholar and Cochrane Library databases were comprehensively searched from their inception to August 2017...
March 2018: Medicine (Baltimore)
Yan Zhang, Jing-Jing Lu, Yi-Ping Du, Chun-Xia Feng, Li-Qiang Wang, Min-Bin Chen
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been presented to be a prognostic indicator in several types of cancer. However, these issues have not been concluded yet. The present study was therefore performed to determine the prognostic value of NLR and PLR in gastric cancer (GC).A total of 182 GC patients, diagnosed between January 2011 and January 2014, were enrolled in the study. The clinicopathological parameters, laboratory analyses, and outcomes were collected...
March 2018: Medicine (Baltimore)
Guangxue Feng, Jie Liu, Chong-Jing Zhang, Bin Liu
Cell organelle targeting is a promising approach for cancer therapy. Herein, we report a mitochondria-targeted light-up probe (TPETH-Mito-1ART) to co-deliver artemisinin (ART) and an AIE photosensitizer (PS) to mitochondria for image-guided combination cancer cell ablation. This probe contains an AIEgen core of TPETH, two mitochondria targeting arms with ART on one arm, which could be internalized into cancer cells over normal ones, and show predominant accumulation and fluorescence turn-on in mitochondria...
March 21, 2018: ACS Applied Materials & Interfaces
Qiong Wang, Hai-Jiao Xing, Na Bao, Ling-Juan Kong, Ye-Juan Jia, Ke Yang, Yan-Hui Sun, Jian-Ling Wang, Jing Shi, Xiao-Feng Li, Jing Xu, Xuan-Ping Zhang, Xin Zhang, Chun-Sheng Jia, Ren-Ling Li
OBJECTIVE: To explore the regularity and characteristics of clinical application of scalp acupuncture therapy for different types of clinical conditions so as to provide a reference for clinical practice. METHODS: In the present study, "head acupuncture" and"scalp acupuncture" were used as the keywords to search papers and academic dissertations having definite standards for diagnosis and therapeutic effect assessment and published in journals and academic conferences collected in database China National Knowledge Internet(CNKI) from January 1 of 1959 to December 31 of 2016, followed by constructing a database after sorting, screening, recording, extracting, and statistical analysis by using a computer...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Zhe Xue, Guan-Yang Song, Xin Liu, Hui Zhang, Guan Wu, Yi Qian, Hua Feng
PURPOSE: The purpose of the study was to quantify the patellar J sign using traditional computed tomography (CT) scans. METHODS: Fifty-three patients (fifty-three knees) who suffered from recurrent patellar instability were included and analyzed. The patellar J sign was evaluated pre-operatively during active knee flexion and extension. It was defined as positive when there was obvious lateral patellar translation, and negative when there was not. The CT scans were performed in all patients with full knee extension; and the parameters including bisect offset index (BOI), patellar-trochlear-groove (PTG) distance, and patellar lateral tilt angle (PLTA) were measured on the axial slices...
March 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Bo Hao, Zhen Chen, Baochen Bi, Miaomei Yu, Shuang Yao, Yuehua Feng, Yang Yu, Lili Pan, Dongmei Di, Guanghua Luo, Xiaoying Zhang
Background: Accumulating evidence showed that high expression of toll like receptor 4 (TLR4) was significantly associated with the outcome of patients with solid cancers. However, other studies failed to draw a similar conclusion. Thus, a systematic meta-analysis was performed to assess the prognostic value of TLR4 in solid tumors. Results: Data from 15 studies and 1294 patients were enrolled. Among the 15 studies, 14 studies demonstrated the association between overall survival(OS) and TLR4 expression, and 7 studies described the relationship between disease-free survival(DFS) and TLR4 expression...
February 27, 2018: Oncotarget
Yuan Huang, Yiming Guo, Yuting Liu, Feng Zhang, Zhikui Wang, Hongyan Wang, Feng Wang, Dongping Li, Dandan Mao, Sheng Luan, Manzhong Liang, Liangbi Chen
Although abscisic acid (ABA) is an important hormone that regulates seed dormancy, stomatal closure, plant development, as well as responses to environmental stimuli, the physiological mechanisms of ABA response to multiple stress in rice remain poorly understood. In the ABA biosynthetic pathway, 9- cis -epoxycarotenoid dioxygenase (NCED) is the key rate-limiting enzyme. Here, we report important functions of OsNCED3 in multi-abiotic stress tolerance in rice. The OsNCED3 is constitutively expressed in various tissues under normal condition, Its expression is highly induced by NaCl, PEG, and H2 O2 stress, suggesting the roles for OsNCED3 in response to the multi-abiotic stress tolerance in rice...
2018: Frontiers in Plant Science
Xue-Lian Liu, Rui-Ying Wu, Xiao-Feng Sun, Shun-Feng Cheng, Rui-Qian Zhang, Tian-Yu Zhang, Xi-Feng Zhang, Yong Zhao, Wei Shen, Lan Li
Zearalenone (ZEA), a metabolite of Fusarium fungi, is commonly found on moldy grains. Because it can competitively combine to estrogen receptor to disrupt estrogenic signaling, it has been reported to have serious adverse effects on animal reproduction systems. In order to explore the genotoxic effects of ZEA exposure on ovarian somatic cells, porcine granulosa cells were exposed to 10 μM and 30 μM ZEA for 24 or 72 h in vitro . The results showed that ZEA exposure for 24 h remarkably reduced the proliferation of porcine granulosa cells in a dose-dependent manner as determined by MTT analysis and flow cytometry...
2018: International Journal of Biological Sciences
Guanghui Xu, Fan Feng, Shushang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Lei Cai, Man Guo, Xiao Lian, Hongwei Zhang
Background: Little is known about the clinicopathological features and prognosis in elderly gastric cancer (GC) patients aged 65-79 years. The aim of this study was to evaluate clinicopathological features and prognosis in elderly GC patients. Patients and methods: From May 2008 to December 2014, a total of 5,282 GC patients were enrolled in our present study. Patients were divided into elderly and middle-aged groups. The clinicopathological features and clinical outcomes were analyzed...
2018: OncoTargets and Therapy
Yuyuan Deng, Zhijie Niu, LiangLiang Fan, Jie Ling, Hongsheng Chen, Xinzhang Cai, Lingyun Mei, Chufeng He, Xuewei Zhang, Jie Wen, Meng Li, Wu Li, Taoxi Li, Shushan Sang, Yalan Liu, Yong Feng
X-linked inheritance is very rare and is estimated to account for only 1-5% of all nonsyndromic hearing loss cases. We found a multiplex family from China segregating with X-linked nonsyndromic hearing loss. After exclusive analysis of 10 common variations of three hearing loss-related genes, GJB2, mtDNA12srRNA and SLC26A4, a novel truncated variant of SMPX, c.87dupA (p.Gly30Argfs*12) (NCBI ClinVar Submission ID: SUB3136126), was identified by whole-exome sequencing. This variant was co-segregated with hearing loss in the entire family and was absent in 576 unrelated ethnically and geographically matched controls...
March 20, 2018: Journal of Human Genetics
Li Guo, Ya-Wei Hao, Pei-Long Li, Jiang-Feng Song, Rui-Zhu Yang, Xiu-Yan Fu, Sheng-Yi Xie, Jing Zhao, Yong-Lai Zhang
We report on the fabrication of a NO2 gas sensor from room-temperature reduction of graphene oxide(GO) via two-beam-laser interference (TBLI). The method of TBLI gives the distribution of periodic dissociation energies for oxygen functional groups, which are capable to reduce the graphene oxide to hierarchical graphene nanostructures, which holds great promise for gaseous molecular adsorption. The fabricated reduced graphene oxide(RGO) sensor enhanced sensing response in NO2 and accelerated response/recovery rates...
March 20, 2018: Scientific Reports
Sheng Li, Shiming Zhu, Qiangqiang Jia, Dongwei Yuan, Chonghua Ren, Kang Li, Suning Liu, Yingying Cui, Haigang Zhao, Yanghui Cao, Gangqi Fang, Daqi Li, Xiaoming Zhao, Jianzhen Zhang, Qiaoyun Yue, Yongliang Fan, Xiaoqiang Yu, Qili Feng, Shuai Zhan
Many cockroach species have adapted to urban environments, and some have been serious pests of public health in the tropics and subtropics. Here, we present the 3.38-Gb genome and a consensus gene set of the American cockroach, Periplaneta americana. We report insights from both genomic and functional investigations into the underlying basis of its adaptation to urban environments and developmental plasticity. In comparison with other insects, expansions of gene families in P. americana exist for most core gene families likely associated with environmental adaptation, such as chemoreception and detoxification...
March 20, 2018: Nature Communications
Ping Luo, Chunzi Liang, Xianwei Zhang, Xuefang Liu, Yingchao Wang, Mengmeng Wu, Xiaobo Feng, Jiangcheng Tu
Hepatocellular carcinoma (HCC) is the third major cause of cancer related death. Abundant researches show that lncRNAs play critical roles in the initiation and progression of HCC and may serve as diagnostic markers for HCC. In the present study, 6 lncRNAs were chosen as candidate genes on the basis of previous literature to evaluate their diagnostic value on HCC by qRT-PCR. Experiment was first carried out in 22 pairs of tissues from HCC and then those differently expressed in tissues were further tested in plasma from 20 HCC patients and 20 control cases...
March 20, 2018: Bioscience Reports
Yingjun Deng, Xin Li, Jinxin Feng, Xiangliang Zhang
CML is a myeloproliferative disease which expresses an active tyrosine kinase, BCR/ABL. As a specific inhibitor of BCR-ABL tyrosine kinase, imatinib becomes the first choice for treatment of CML due to its high efficacy and low toxicity. However, the development of imatinib resistance limits the long-term treatment benefit. so, we aimed to investigate the roles of miR-202 in the regulation of imatinib sensitivity in CML cell lines and the possible mechanisms involved. We found miR-202 was downregulated in seven CML cell lines by qRT-PCR analysis...
March 20, 2018: Bioscience Reports
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