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https://www.readbyqxmd.com/read/28927095/high-expression-of-mage-a9-is-associated-with-unfavorable-survival-in-esophageal-squamous-cell-carcinoma
#1
Yu Qi, Ke Xin Cao, Fu Chen Xing, Chun Yang Zhang, Qi Huang, Kai Wu, Feng Biao Wen, Song Zhao, Xin Li
Melanoma-associated antigens (MAGEs) are a group of well-characterized members of the cancer/testis antigen family, which are expressed in a variety of malignant tumors. MAGE-A9, a subfamily of MAGE-As, has been studied in a number of types of cancer and have been associated with unfavorable survival outcome. However, the expression of MAGE-A9 in human esophageal squamous cell carcinoma (ESCC) and association of MAGE-A9 with the clinicopathological characteristics of ESCC, particularly prognostic characteristics, remains unknown...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927035/decreased-expression-of-speckle-type-poz-protein-for-the-prediction-of-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#2
Jing-Jing Li, Jian-Feng Zhang, Su-Mei Yao, Hua Huang, Shu Zhang, Minxing Zhao, Jian-An Huang
Speckle-type POZ domain protein (SPOP) has been acknowledged as a tumor suppressor gene in numerous types of cancer. However, SPOP expression and its prognostic role in human non-small cell lung cancer (NSCLC) remain unknown. The present study investigated SPOP expression in NSCLC and evaluated its prognostic significance in patients with NSCLC. The results demonstrated that SPOP expression was significantly downregulated in NSCLC tissues at the mRNA and protein level compared with normal lung tissues using reverse transcription-quantitative polymerase chain reaction, and western blot analysis...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927032/clinical-study-of-radiofrequency-ablation-combined-with-tace-in-the-treatment-of-breast-cancer-with-liver-metastasis
#3
Haijun Wang, Bin Liu, Houlong Long, Fengfeng Zhang, Silei Wang, Feng Li
We studied the clinical effects of percutaneous radiofrequency ablation (RFCA) combined with trans-catheter arterial chemoembolization (TACE) in the treatment of breast cancer with liver metastasis. Eighty-eight patients with a diagnosis of breast cancer with liver metastasis for the first time and patients with liver metastasis after radical mastectomy were consecutively selected. The subjects were divided according to the different treatment methods. They were divided either into the control group of 50 cases or the observation group of 38 cases...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926582/selection-of-possible-signature-peptides-for-the-detection-of-bovine-lactoferrin-in-infant-formulas-by-lc-ms-ms
#4
Mingmei Yuan, Cong Feng, Shouyun Wang, Weiwei Zhang, Mo Chen, Hong Jiang, Xuesong Feng
An LC-MS/MS assay based on a signature peptide was developed and fully validated for the quantitation of bovine lactoferrin in infant formulas. Three unreported signature peptides were derived and identified from the tryptic peptides of bovine lactoferrin. The peptide ETTVFENLPEK was used for quantification based on assay performance. The blank matrix camel milk powder and bovine lactoferrin protein standards were mixed and spiked with stable isotope-labeled internal standard to establish a calibration curve...
2017: PloS One
https://www.readbyqxmd.com/read/28926527/genistein-suppresses-aerobic-glycolysis-and-induces-hepatocellular-carcinoma-cell-death
#5
Sainan Li, Jingjing Li, Weiqi Dai, Qinghui Zhang, Jiao Feng, Liwei Wu, Tong Liu, Qiang Yu, Shizan Xu, Wenwen Wang, Xiya Lu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Wenhui Mo, Ling Xu, Chuanyong Guo
BACKGROUND: Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated with an increased risk of mortality, cancer progression, and resistance to therapy. However, the effect of genistein on HIF-1α and glycolysis in hepatocellular carcinoma (HCC) is still unclear. METHODS: Cell viability, apoptosis rate, lactate production, and glucose uptake were measured in HCC cell lines with genistein incubation...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28926285/the-role-of-acrab-tolc-efflux-pump-in-mediating-fluoroquinolone-resistance-in-naturally-occurring-salmonella-isolates-from-china
#6
Jinling Shen, Baowei Yang, Qiang Gu, Guodong Zhang, Jielin Yang, Feng Xue, Jingdong Shao, Xiaojuan Yi, Yuan Jiang
The involvement of AcrAB-TolC efflux pump in regulating fluoroquinolone resistance of naturally occurring Salmonella isolates is insufficiently investigated. In this study, the regulatory genes, acrR, ramR, marRAB, and soxRS of AcrAB-TolC efflux pump, of 27 naturally occurring fluoroquinolone-resistant Salmonella isolates collected in China were sequenced. The expression levels of acrB, ramA, marA, and soxS were also examined using quantitative real-time polymerase chain reaction. Gene alterations were mainly observed for acrR (three mutation types) and ramR (four mutation types), not for marRAB (no mutation) or soxRS (one mutaton type)...
September 19, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28926148/biodiversity-and-species-competition-regulate-the-resilience-of-microbial-biofilm-community
#7
Kai Feng, Zhaojing Zhang, Weiwei Cai, Wenzong Liu, Meiying Xu, Huaqun Yin, Aijie Wang, Zhili He, Ye Deng
The relationship between biodiversity and ecosystem stability is poorly understood in microbial communities. Biofilm communities in small bioreactors called microbial electrolysis cells (MEC) contain moderate species numbers and easy tractable functional traits, thus providing an ideal platform for verifying ecological theories in microbial ecosystems. Here, we investigated the resilience of biofilm communities with a gradient of diversity, and explored the relationship between biodiversity and stability in response to a pH shock...
September 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28926119/procaine-is-a-specific-dna-methylation-inhibitor-with-anti-tumor-effect-for-human-gastric-cancer
#8
Yong-Chao Li, Yun Wang, Dan-Dan Li, Ying Zhang, Tian-Cheng Zhao, Chang-Feng Li
DNA hypermethylation and the silencing of tumor suppressor genes caused by DNA hypermethylation is considered as a molecular hallmark of many kinds of cancers. Procaine, a local anesthetic, has been shown as a potential DNA methylation inhibitor in some types of cancers. However, the influence of procaine on DNA methylation regulation as well as the biological function in gastric cancer is still unknown. We report here that procaine represses the DNA-methylation level and promotes the proliferation arrest and apoptosis of gastric cancer cells...
September 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28926090/efficacy-of-different-chemotherapy-regimens-in-treatment-of-advanced-or-metastatic-pancreatic-cancer-a-network-meta-analysis
#9
Shu-Hua Zhang, Gui-Feng Liu, Xue-Feng Li, Lin Liu, Shao-Nan Yu
We performed a network meta-analysis (NMA) to compare the short- and long-term efficacy of Gemcitabine, Gemcitabine + S-1 (tegafur), Gemcitabine + nab-paclitaxel, Gemcitabine + Capecitabine, Gemcitabine + Cisplatin, FOLFIRINOX (oxaliplatin + irinotecan + fluorouracil + leucovorin), Gemcitabine + oxaliplatin, Gemcitabine + irinotecan, Gemcitabine + Exatecan, Gemcitabine + pemetrexed, Gemcitabine + 5-FU and S-1 in treating advanced or metastatic pancreatic cancer (PC)...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925979/a-new-quaternion-based-kalman-filter-for-real-time-attitude-estimation-using-the-two-step-geometrically-intuitive-correction-algorithm
#10
Kaiqiang Feng, Jie Li, Xiaoming Zhang, Chong Shen, Yu Bi, Tao Zheng, Jun Liu
In order to reduce the computational complexity, and improve the pitch/roll estimation accuracy of the low-cost attitude heading reference system (AHRS) under conditions of magnetic-distortion, a novel linear Kalman filter, suitable for nonlinear attitude estimation, is proposed in this paper. The new algorithm is the combination of two-step geometrically-intuitive correction (TGIC) and the Kalman filter. In the proposed algorithm, the sequential two-step geometrically-intuitive correction scheme is used to make the current estimation of pitch/roll immune to magnetic distortion...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28925760/comparison-of-the-conventional-surgery-and-the-surgery-assisted-by-3d-printing-technology-in-the-treatment-of-calcaneal-fractures
#11
Wenhao Zheng, Zhenyu Tao, Yiting Lou, Zhenhua Feng, Hang Li, Liang Cheng, Hui Zhang, Jianshun Wang, Xiaoshan Guo, Hua Chen
PURPOSE: This study was aimed to compare conventional surgery and surgery assisted by 3D printing technology in the treatment of calcaneal fractures. In addition, we also investigated the effect of 3D printing technology on the communication between doctors and patients. METHODS: we enrolled 75 patients with calcaneal fracture from April 2014 to August 2016. They were divided randomly into two groups: 35 cases of 3D printing group, 40 cases of conventional group...
September 19, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28925544/metaproteomics-of-marine-viral-concentrates-reveals-key-viral-populations-and-abundant-periplasmic-proteins-in-the-oligotrophic-deep-chlorophyll-maximum-of-the-south-china-sea
#12
Zhang-Xian Xie, Feng Chen, Shu-Feng Zhang, Ming-Hua Wang, Hao Zhang, Ling-Fen Kong, Min-Han Dai, Hua-Sheng Hong, Lin Lin, Da-Zhi Wang
Viral concentrates (VCs), containing bio-informative DNA and proteins, have been used to study viral diversity, viral metagenomics and virus-host interactions in natural ecosystems. Besides viruses, VCs also contain many non-cellular biological components including diverse functional proteins. Here, we used a shotgun proteomic approach to characterize the proteins of VCs collected from the oligotrophic deep chlorophyll maximum (DCM) of the South China Sea. Proteins of viruses infecting picophytoplankton, i...
September 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28925493/repair-and-sensory-reconstruction-of-the-children-s-finger-pulp-defects-with-perforator-pedicled-propeller-flap-in-proper-digital-artery
#13
S-M Feng, A-G Wang, Z-Y Zhang, Q-Q Sun, Y-L Tao, M-M Zhou, Y-J Hao
OBJECTIVE: This study was designed to investigate the clinical effects of adopting perforator pedicled propeller flap in the proper digital artery for treatment and sensory reconstruction of finger pulp defects in children. PATIENTS AND METHODS: Perforator pedicled propeller flap of proper digital arteries in thirty-one fingers from twenty-three children patients were selected for repairing the pulp defects on the 2nd to the 5th fingers. All cases were treated from September 2012 to December 2013...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28925170/-analysis-of-projects-funded-by-nsfc-in-field-of-chinese-material-medica-resource-in-recent-three-years
#14
Wei Gao, Shu-Zhen Guo, Li-Wei Han, Feng-Zhu Zhang
The paper reviewed the sponsorship and final reports of projects focus on Science of Chinese materia medica resource in Medical Science Department, National Natural Science Foundation of China. The applicant and supportive organizations were analyzed. The progress and results of some projects were summarized by research fields including formation mechanism of Dao-di herbs, research of plant taxonomy, breeding and cultivation of medical plants, ecological and environmental adaptability of Chinese materia medica resource, quality assessment of Chinese materia medica resource, and biosynthesis and regulation of active compounds...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925153/-advances-on-chemical-constituents-and-pharmacological-activities-of-ceriops-genus
#15
Qing-Feng Guo, Lin Chen, Jing-Wei Ma, Yong Zhang
Plants of the genus Ceriops (Rhizophoraceae) consist of five species, which were widely distributed in tropical Asia, Eastern Africa and Oceania. So far,phytochemical studies showed that a total of 131 compounds including 120 terpenoids had been isolated from this genus, which exhibited anti-inflammatory, antihyperglycaemic, antitumor, anti-microbial, antioxidant, antifouling and antiviral activities. This article summarized the recent research progress of the chemical compositions and their pharmacological activities from the genus,which could provide reference for the development and utilization of the Ceriops plants...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28923710/spatiotemporal-drought-variability-on-the-mongolian-plateau-from-1980-2014-based-on-the-spei-pm-intensity-analysis-and-hurst-exponent
#16
Siqin Tong, Quan Lai, Jiquan Zhang, Yuhai Bao, A Lusi, Qiyun Ma, Xiangqian Li, Feng Zhang
Knowledge about variations of drought can provide a scientific basis for water resource planning and drought mitigation. In this study, the variations and patterns of drought identified by the Standardized Precipitation Evapotranspiration Index (SPEI) were investigated on the Mongolian Plateau for the period 1980-2014, based on intensity analysis, linear regression, the Mann-Kendall test, wavelet analysis, and Hurst exponent. The results show that: 1) the annual SPEI decreased at a rate of -0.0133/yr over the past 35years, and a major abrupt change occurred in 1999; 2) drought on the Mongolian Plateau intensified from 1980 to 2014, and the drought in Mongolia has been more serious than in Inner Mongolia since the beginning of the 21st century; 3) the rate of drought/wet changes in 1980s-1990s and 1990s-2000s were faster than in 2000s-2010s...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28923691/submucosal-tunneling-endoscopic-resection-vs-thoracoscopic-enucleation-for-large-submucosal-tumors-in-the-esophagus-and-the-esophagogastric-junction
#17
Tao Chen, Zong-Wu Lin, Yi-Qun Zhang, Wei-Feng Chen, Yun-Shi Zhong, Qun Wang, Li-Qing Yao, Ping-Hong Zhou, Mei-Dong Xu
BACKGROUND: Submucosal tunneling endoscopic resection (STER) is regarded as a promising method for resection of submucosal tumors (SMTs); however, little is known about a comprehensive comparison of STER and thoracoscopic enucleation (TE). The aim of this study is to compare the clinical outcomes of STER and TE for large symptomatic SMTs in the esophagus and the esophagogastric junction (EGJ), as well as to analyze the factors that affect the feasibility and safety of STER. STUDY DESIGN: We enrolled 166 patients with large symptomatic SMTs in the esophagus and the EGJ from September 2011 and March 2016 in this retrospective study...
September 15, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28923636/effect-of-preoperative-growth-status-on-clinical-outcomes-after-living-donor-liver-transplantation-in-infants
#18
Y Lu, Q Xia, Y Yang, P Wan, J Hou, Y Wang, B Qiu, M Feng, K He, M Huang, X Ren, L Gao, J Zhang
OBJECTIVE: The aim of this study was to evaluate the impact of preoperative growth status on clinical outcomes of infantile living-donor liver transplantation (LDLT). METHODS: From January 2009 to December 2014, 131 LDLT recipients ≤1 year of age met the eligibility criteria of this study, of whom 31 patients with weight z-scores less than -2 constituted the abnormal growth group. Patients in the abnormal growth group were randomly matched (1:1) to patients with normal growth status by means of a multivariate case-matched method, and thus 31 patients in the normal growth group and 31 patients in the abnormal growth group were finally enrolled into the study...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923553/a-systematic-integrated-analysis-of-brain-expression-profiles-reveals-yap1-and-other-prioritized-hub-genes-as-important-upstream-regulators-in-alzheimer-s-disease
#19
Min Xu, Deng-Feng Zhang, Rongcan Luo, Yong Wu, Hejiang Zhou, Li-Li Kong, Rui Bi, Yong-Gang Yao
INTRODUCTION: Profiling the spatial-temporal expression pattern and characterizing the regulatory networks of brain tissues are vital for understanding the pathophysiology of Alzheimer's disease (AD). METHODS: We performed a systematic integrated analysis of expression profiles of AD-affected brain tissues (684 AD and 562 controls). A network-based convergent functional genomic approach was used to prioritize possible regulator genes during AD development, followed by functional characterization...
September 15, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28923067/a-new-insight-into-male-fertility-preservation-for-patients-with-completely-immotile-spermatozoa
#20
Huanhua Chen, Guixue Feng, Bo Zhang, Hong Zhou, Caizhu Wang, Jinhui Shu, Xianyou Gan, Ruoyun Lin, Dongmei Huang, Yingqin Huang
BACKGROUND: Sperm cryopreservation is the most effective method to preserve male fertility but this is normally used for motile spermatozoa. Thus, only motile spermatozoa are used for cryopreservation in most reproductive medicine centers worldwide. The immotile spermatozoa from some problematic patients are usually discarded, resulting in a missed opportunity of sterility cryopreservation for future assisted reproductive treatments. Many studies have shown that successful fertilization can be obtained after selection of viable sperm from the completely immotile spermatozoa before ICSI...
September 18, 2017: Reproductive Biology and Endocrinology: RB&E
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