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https://www.readbyqxmd.com/read/29166710/-effects-of-hydrogen-on-the-lung-damage-of-mice-at-early-stage-of-severe-burn
#1
C Qin, Y X Bian, T T Feng, J H Zhang, Y H Yu
Objective: To investigate the effects of hydrogen on the lung damage of mice at early stage of severe burn. Methods: One hundred and sixty ICR mice were divided into sham injury, hydrogen, pure burn, and burn+ hydrogen groups according to the random number table, with 40 mice in each group. Mice in pure burn group and burn+ hydrogen group were inflicted with 40% total body surface area full-thickness scald (hereafter referred to as burn) on the back, while mice in sham injury group and hydrogen group were sham injured...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166309/surgeon-sleep-deprivation-surgical-complications-and-the-ethical-imperatives-of-evidence-based-persuasion
#2
William Lineaweaver, Scott Corlew, Feng Zhang
INTRODUCTION: A proposed relationship between surgeon sleep deprivation (SSD) and increased patient complications is examined through a review of published studies and application of standards of evidence-based persuasion. METHODS: Published studies of SSD and patient complications were analyzed to evaluate reported relationships between SSD and surgical complications. The basis of a reported "83% increase" in patient complication associated with SSD was reexamined at its original data source...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29165648/structure-modeling-of-rna-using-sparse-nmr-constraints
#3
Benfeard Williams, Bo Zhao, Arpit Tandon, Feng Ding, Kevin M Weeks, Qi Zhang, Nikolay V Dokholyan
RNAs fold into distinct molecular conformations that are often essential for their functions. Accurate structure modeling of complex RNA motifs, including ubiquitous non-canonical base pairs and pseudoknots, remains a challenge. Here, we present an NMR-guided all-atom discrete molecular dynamics (DMD) platform, iFoldNMR, for rapid and accurate structure modeling of complex RNAs. We show that sparse distance constraints from imino resonances, which can be readily obtained from routine NMR experiments and easier to compile than laborious assignments of non-solvent-exchangeable protons, are sufficient to direct a DMD search for low-energy RNA conformers...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165568/second-harmonic-generation-reveals-subtle-fibrosis-differences-in-adult-and-pediatric-nonalcoholic-fatty-liver-disease
#4
Feng Liu, Jing-Min Zhao, Hui-Ying Rao, Wei-Miao Yu, Wei Zhang, Neil D Theise, Aileen Wee, Lai Wei
Objectives: Investigate subtle fibrosis similarities and differences in adult and pediatric nonalcoholic fatty liver disease (NAFLD) using second harmonic generation (SHG). Methods: SHG/two-photon excitation fluorescence imaging quantified 100 collagen parameters and determined qFibrosis values by using the nonalcoholic steatohepatitis (NASH) Clinical Research Network (CRN) scoring system in 62 adult and 36 pediatric NAFLD liver specimens. Results: Six distinct parameters identified differences among the NASH CRN stages with high accuracy (area under the curve, 0835-0...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29165475/effect-of-the-water-fraction-isolated-from-fructus-ligustri-lucidi-extract-on-bone-metabolism-via-antagonizing-a-calcium-sensing-receptor-in-experimental-type-1-diabetic-rats
#5
Nan-Nan Sha, Yong-Jian Zhao, Dong-Feng Zhao, Daniel Kam-Wah Mok, Qi Shi, Yong-Jun Wang, Yan Zhang
Our previous studies have demonstrated that the extract of Fructus Ligustri Lucidi (FLL) can maintain in vivo calcium homeostasis in aged and ovariectomized rats. This study was designed to elucidate the action of water fraction isolated from the FLL extract on bone metabolism and a calcium-sensing receptor (CaSR) in parathyroid glands and kidneys of diabetic rats. The streptozotocin-induced diabetic rats were treated with vehicle, FLL extract, and the water fraction (WF) isolated from the FLL extract for 4 weeks...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165238/clusters-of-human-infection-and-human-to-human-transmission-of-avian-influenza-a-h7n9-virus-2013-2017
#6
Lei Zhou, Enfu Chen, Changjun Bao, Nijuan Xiang, Jiabing Wu, Shengen Wu, Jian Shi, Xianjun Wang, Yaxu Zheng, Yi Zhang, Ruiqi Ren, Carolyn M Greene, Fiona Havers, A Danielle Iuliano, Ying Song, Chao Li, Tao Chen, Yali Wang, Dan Li, Daxin Ni, Yanping Zhang, Zijian Feng, Timothy M Uyeki, Qun Li
To detect changes in human-to-human transmission of influenza A(H7N9) virus, we analyzed characteristics of 40 clusters of case-patients during 5 epidemics in China in 2013-2017. Similarities in number and size of clusters and proportion of clusters with probable human-to-human transmission across all epidemics suggest no change in human-to-human transmission risk.
February 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29164890/divergent-access-to-functionalized-pyrrolidines-and-pyrrolines-via-iridium-catalyzed-domino-ring-opening-cyclization-of-vinyl-aziridines-with-%C3%AE-ketocarbonyls
#7
Tao-Yan Lin, Hai-Hong Wu, Jian-Jun Feng, Junliang Zhang
A useful synthesis of five-membered N-heterocycles has been developed through an iridium-catalyzed domino-ring-opening cyclization of vinylaziridines with β-ketocarbonyls. α-Substituted 1,3-dicarbonyls reacted with vinylaziridines to give 2-methylenepyrrolidines bearing two adjacent sp(3)-carbon centers with moderate to excellent diastereoselectivity, while the reaction of α-unsubstituted 1,3-dicarbonyls afforded 2-pyrrolines in good yield.
November 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/29164866/electrochemical-analysis-of-enzyme-based-on-the-self-assembly-of-lipid-bilayer-on-an-electrode-surface-mediated-by-hydrazone-chemistry
#8
Juan Zhang, Xiaonan Wang, Tingjun Chen, Chang Feng, Genxi Li
In this work, a new strategy for electrochemical analysis of enzyme has been proposed based on a self-assembled lipid bilayer on an electrode surface mediated by hydrazone chemistry. Taking aldolase as an example, the enzyme can catalyze the formation of products containing carbonyl groups. These groups can react with hydrazine groups of the functional lipid derivative, resulting in the self-assembly of lipid bilayer on a guanidinium modified electrode surface. The lipid bilayer will then prevent the movement of hydrophilic electrochemical probes...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29164525/heat-shock-factor-4-regulates-the-expression-of-hsp25-and-alpha-b-crystallin-by-associating-with-dexd-h-box-rna-helicase-uap56
#9
Xiukun Cui, Wenxiu Han, Jing Li, Riping Feng, Zheng Zhou, JiuLi Han, Mengyuan Li, Shuangfeng Wang, Wanting Zhang, Qin Lei, Jun Zhang, Yutiao Liu, Yanzhong Hu
Heat shock factor 4 controls the transcription of small heat shock proteins (e.g., HSP25, alpha B-cyrstallin, and r-crystallin), that play important roles in modulating lens proteostasis. However, the molecular mechanism underlying HSF4-mediated transcription is still unclear. Using yeast two hybrid, we found that HSF4 interacts with the ATP-dependent DEXD/H-box RNA helicase UAP56, and their interaction in lens epithelial cell line was further confirmed by GST-pull down assay. UAP56 is a vital regulator of pre-mRNA splicing and mature mRNA nuclear export...
November 21, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29164460/di-2-ethylhexyl-phthalate-induces-glucose-metabolic-disorder-in-adolescent-rats
#10
Jin Xu, Liting Zhou, Shuyue Wang, Jian Zhu, Te Liu, Yiyang Jia, Di Sun, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Hongbo Liu, Tianrong Zhang, Lin Ye
As a plasticizer, di-(2-ethylhexyl)-phthalate (DEHP) is widely added in various commercial products. Some researchers had suggested that DEHP has adverse effects on the glucose metabolism, but the mechanisms remain unclear. Adolescent Wistar rats were divided into four groups and administered DEHP by gavage at 0, 5, 50, and 500 mg kg(-1) d(-1) for 28 days. ELISA was used to quantify the serum insulin and leptin levels; RT-PCR, immunohistochemistry, and Western blot were used to detect the mRNA and protein expressions of Janus-activated kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), suppressor of cytokine signaling 3 (SOCS3), leptin receptor (Ob-R), and insulin receptor (IR) in liver and pancreas In comparison to the control group, the DEHP-treated rats showed the following: (1) higher organ coefficient of liver; (2) higher fasting blood glucose levels, higher fasting serum insulin and leptin levels, higher insulin resistance index homeostasis model assessment; (3) lower protein levels of Ob-R and IR in the liver and pancreas; (4) higher protein levels of JAK2 and STAT3 in the liver; and (5) higher protein and mRNA levels of SOCS3 in the liver and pancreas...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29164394/combination-of-nad-and-nadph-offers-greater-neuroprotection-in-ischemic-stroke-models-by-relieving-metabolic-stress
#11
Qiao Huang, Meiling Sun, Mei Li, Dingmei Zhang, Feng Han, Jun Chao Wu, Kohji Fukunaga, Zhong Chen, Zheng-Hong Qin
Both reduced nicotinamide adenine dinucleotide phosphate (NADPH) and β-nicotinamide adenine dinucleotide hydrate (NAD(+)) have been reported to have potent neuroprotective effects against ischemic neuronal injury. Both NADPH and NAD(+) are essential cofactors for anti-oxidation and cellular energy metabolism. We investigated if combined NADPH and NAD(+) could offer better neuroprotective effects on cellular and animal models of ischemic stroke. In vitro studies with primary cultured neurons demonstrated that NAD(+) was effective in protecting neurons against oxygen-glucose deprivation/reoxygenation (OGD/R) injury when given during the early time period of reoxygenation...
November 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29164214/withapubesides-a-d-natural-inducible-nitric-oxide-synthase-inos-inhibitors-from-physalis-pubescens
#12
Gui-Yang Xia, Tie Yao, Bing-Yang Zhang, Yang Li, Ning Kang, Shi-Jie Cao, Li-Qin Ding, Li-Xia Chen, Feng Qiu
Four new steroid glycosides, withapubesides A-D (1-4), were isolated from the stems of Physalis pubescens L. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were deduced by single-crystal X-ray diffraction and ECD data analysis, respectively. Compound 3 has shown significant inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with an IC50 value of 12.8 μM and moderate cytostatic activity against human carcinoma cells (786-O, C4-2B, 22Rvl, A375 and A375S2) with IC50 values in the range of 3...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29164212/elemental-sulfur-mediated-2-substituted-benzothiazole-formation-from-2-aminobenzenethiols-and-arylacetylenes-or-styrenes-under-metal-free-conditions
#13
Guozheng Li, Jingjing Jiang, Feng Zhang, Fuhong Xiao, Guo-Jun Deng
An oxidative cyclization of 2-aminothiophenols and arylacetylenes or styrenes for the synthesis of 2-alkylbenzothiazoles and 2-acylbenzothiazoles has been developed. Elemental sulfur was used as the effective oxidant to give the corresponding product in good yield under metal-free conditions.
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29163982/individual-differences-in-schizophrenia
#14
Edmund T Rolls, Wenlian Lu, Lin Wan, Hao Yan, Chuanyue Wang, Fude Yang, Yunlong Tan, Lingjiang Li, Hao Yu, Peter F Liddle, Lena Palaniyappan, Dai Zhang, Weihua Yue, Jianfeng Feng
Background: Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia. Aims: To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how first-episode patients (FEP) may differ from multiple episode patients (MEP). Method: These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29163828/surrogate-endpoint-for-overall-survival-in-assessment-of-adjuvant-therapies-after-curative-treatment-for-hepatocellular-carcinoma-a-re-analysis-of-meta-analyses-of-individual-patients-data
#15
Hong-Bo Huan, Li-Li Wu, Wan-Yee Lau, Xu-Dong Wen, Liang Zhang, Da-Peng Yang, Xi-Shu Wang, Ping Bie, Feng Xia
The gold standard endpoint to evaluate the effect of treatment for hepatocellular carcinoma (HCC) is overall survival (OS), but it requires a longer follow-up period to observe. This study aimed to identify whether disease-free survival (DFS) could be used as a surrogate endpoint for OS to assess the efficacy of adjuvant therapies after curative treatment (surgical resection and ablation) for HCC patients. A systematic review was conducted to identify trials about curative treatment combined with or without adjuvant therapies (interferon, IFN; or transarterial chemoembolization, TACE) for HCC...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163822/structural-basis-of-the-therapeutic-anti-pd-l1-antibody-atezolizumab
#16
Fei Zhang, Xiaoqiang Qi, Xiaoxiao Wang, Diyang Wei, Jiawei Wu, Lingling Feng, Haiyan Cai, Yugang Wang, Naiyan Zeng, Ting Xu, Aiwu Zhou, Ying Zheng
Monoclonal antibodies targeting PD-1/PD-L1 signaling pathway have achieved unprecedented success in cancer treatment over the last few years. Atezolizumab is the first PD-L1 monoclonal antibody approved by US FDA for cancer therapy; however the molecular basis of atezolizumab in blocking PD-1/PD-L1 interaction is not fully understood. Here we have solved the crystal structure of PD-L1/atezolizumab complex at 2.9 angstrom resolution. The structure shows that atezolizumab binds the front beta-sheet of PD-L1 through three CDR loops from the heavy chain and one CDR loop from the light chain...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163777/dhx15-is-associated-with-poor-prognosis-in-acute-myeloid-leukemia-aml-and-regulates-cell-apoptosis-via-the-nf-kb-signaling-pathway
#17
Lili Pan, Yang Li, Hai-Ying Zhang, Yi Zheng, Xiao-Li Liu, Zheng Hu, Yi Wang, Jing Wang, Yuan-Hua Cai, Qiao Liu, Wan-Ling Chen, Ying Guo, Yuan-Mao Huang, Feng Qian, Li Jin, Jiucun Wang, Shao-Yuan Wang
The role of DHX15, a newly identified DEAH-box RNA helicase, in leukemogenesis remains elusive. Here, we identified a recurrent mutation in DHX15 (NM_001358:c.664C>G: p.(R222G)) in one familial AML patient and 4/240 sporadic AML patients. Additionally, DHX15 was commonly overexpressed in AML patients and associated with poor overall survival (OS) (P=0.019) and relapse-free survival (RFS) (P=0.032). In addition, we found a distinct expression pattern of DHX15. DHX15 was highly expressed in hematopoietic stem cells and leukemia cells but was lowly expressed in mature blood cells...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163770/role-of-microenvironmental-periostin-in-pancreatic-cancer-progression
#18
Yang Liu, Fan Li, Feng Gao, Lingxi Xing, Peng Qin, Xingxin Liang, Jiajie Zhang, Xiaohui Qiao, Lizhou Lin, Qian Zhao, Lianfang Du
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic reaction. Pancreatic stellate cells (PSCs) are the principal effector cells responsible for stroma production. Aberrant up-regulation of periostin expression has been reported in activated PSCs. In this study, we investigated the role of periostin and the mechanisms underlying its aberrant upregulation in PDAC. We used lentiviral shRNA and human recombinant periostin protein to down and up regulate periostin expression in vitro...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163712/combinations-of-elevated-tissue-mirna-17-92-cluster-expression-and-serum-prostate-specific-antigen-as-potential-diagnostic-biomarkers-for-prostate-cancer
#19
Sujuan Feng, Xiaosong Qian, Han Li, Xiaodong Zhang
The aim of the present study was to investigate the effectiveness of the miR-17-92 cluster as a disease progression marker in prostate cancer (PCa). Reverse transcription-quantitative polymerase chain reaction analysis was used to detect the microRNA (miR)-17-92 cluster expression levels in tissues from patients with PCa or benign prostatic hyperplasia (BPH), in addition to in PCa and BPH cell lines. Spearman correlation was used for comparison and estimation of correlations between miRNA expression levels and clinicopathological characteristics such as the Gleason score and prostate-specific antigen (PSA)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163593/osarm1-an-r2r3-myb-transcription-factor-is-involved-in-regulation-of-the-response-to-arsenic-stress-in-rice
#20
Feng-Zhu Wang, Mo-Xian Chen, Lu-Jun Yu, Li-Juan Xie, Li-Bing Yuan, Hua Qi, Ming Xiao, Wuxiu Guo, Zhe Chen, Keke Yi, Jianhua Zhang, Rongliang Qiu, Wensheng Shu, Shi Xiao, Qin-Fang Chen
Bioaccumulation of arsenic (As) in rice (Oryza sativa) increases human exposure to this toxic, carcinogenic element. Recent studies identified several As transporters, but the regulation of these transporters remains unclear. Here, we show that the rice R2R3 MYB transcription factor OsARM1 (ARSENITE-RESPONSIVE MYB1) regulates As-associated transporters genes. Treatment with As(III) induced OsARM1 transcript accumulation and an OsARM1-GFP fusion localized to the nucleus. Histochemical analysis of OsARM1pro::GUS lines indicated that OsARM1 was expressed in the phloem of vascular bundles in basal and upper nodes...
2017: Frontiers in Plant Science
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