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HPV & DNA

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https://www.readbyqxmd.com/read/28212672/cytokeratin7-and-cytokeratin19-expression-in-high-grade-cervical-intraepithelial-neoplasm-and-squamous-cell-carcinoma-and-their-possible-association-in-cervical-carcinogenesis
#1
Hojung Lee, Hyekyung Lee, Yong Kyun Cho
BACKGROUND: High risk human papillomavirus (HR HPV) infects cells at the squamocolumnar junction (SCJ) of the cervix, causing cancer. Cytokeratin (CK)7 is an SCJ marker, and stains cervical neoplasia. CK19 is a binding partner of CK7 and expressed in cervical cancer. Despite this possible association between CK7/CK19 and cervical cancer, not much is known about the mechanism of CK7/CK19 involvement in HR HPV-mediated cervical carcinogenesis. METHODS: We analyzed the expression pattern of CK7, CK19, and p16 by using immunohistochemistry and HPV infection by in situ hybridization in 25 cases of high grade cervical intraepithelial neoplasia (CIN3) and in 30 cases of squamous cell carcinoma (SCC)...
February 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28212457/papillomaviruses-a-systematic-review
#2
Rodrigo Pinheiro Araldi, Suely Muro Reis Assaf, Rodrigo Franco de Carvalho, Márcio Augusto Caldas Rocha de Carvalho, Jacqueline Mazzuchelli de Souza, Roberta Fiusa Magnelli, Diego Grando Módolo, Franco Peppino Roperto, Rita de Cassia Stocco, Willy Beçak
In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds...
February 16, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28210481/human-papillomavirus-hpv-virion-induced-cancer-and-subfertility-two-sides-of-the-same-coin
#3
REVIEW
T Depuydt, J Beert, E Bosmans, G Salembier
In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28202002/viral-e6-is-overexpressed-via-high-viral-load-in-invasive-cervical-cancer-with-episomal-hpv16
#4
Die Hong, Jia Liu, Ying Hu, Xiaonan Lu, Baohua Li, Yang Li, Dongxiao Hu, Weiguo Lu, Xing Xie, Xiaodong Cheng
BACKGROUND: The integration of HR-HPV genome into host DNA is regarded as a key step for the development of cervical cancer. However, HR-HPV genome indeed exists as episome except for integrant. It may be alternative mechanisms in episome-associated carcinogenesis, although, by which HPV 16 episome induces cervical carcinogenesis is unclear now. METHODS: Ninety-three invasive cervical cancer tissues with HPV16 positive were collected. Viral physical status was calculated from comparing E2 to E6-copies and detection of viral load was made with realtime-PCR using copy numbers of E6...
February 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28199413/low-prevalence-of-human-papillomavirus-in-head-and-neck-squamous-cell-carcinoma-in-the-northwest-region-of-the-philippines
#5
Pia Marie Albano, Dana Holzinger, Christianne Salvador, Jose Orosa, Sheryl Racelis, Modesty Leaño, Danilo Sanchez, Lara Mae Angeles, Gordana Halec, Markus Schmitt, John Donnie Ramos, Michael Pawlita
BACKGROUND: Geographic heterogeneity of human papillomavirus (HPV) involvement in head and neck squamous cell carcinoma (HNSCC) has been observed over the last few years. This trend has not been evaluated in the Philippines. Hence, this study aims to provide for the first time a data on the prevalence of HPV in HNSCC in the northwestern region of the Philippines. METHODS: Two hundred one (201) biopsy samples (179 formalin fixed paraffin embedded and 22 fresh frozen) from 163 Filipino HNSCC cases (oral cavity = 88; larynx = 60; oropharynx = 15) diagnosed between 2003 to 2013 were initially included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28198978/high-prevalence-of-human-papillomavirus-hpv-in-oral-mucosal-lesions-of-patients-at-the-ambulatory-of-oral-diagnosis-of-the-federal-university-of-sergipe-northeastern-brazil
#6
Mariana Goveia Melo Ribeiro, Larissa Doddi Marcolino, Bruna Ribeiro de Andrade Ramos, Elaine Alves Miranda, Cleverson Luciano Trento, Sona Jain, Ricardo Queiroz Gurgel, Márcia Guimarães da Silva, Silvio Santana Dolabella
Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28196964/fancd2-binds-human-papillomavirus-genomes-and-associates-with-a-distinct-set-of-dna-repair-proteins-to-regulate-viral-replication
#7
Chelsey C Spriggs, Laimonis A Laimins
The life cycle of human papillomavirus (HPV) is dependent on the differentiation state of its host cell. HPV genomes are maintained as low-copy episomes in basal epithelial cells and amplified to thousands of copies per cell in differentiated layers. Replication of high-risk HPVs requires the activation of the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) DNA repair pathways. The Fanconi anemia (FA) pathway is a part of the DNA damage response and mediates cross talk between the ATM and ATR pathways...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28193254/developing-a-new-diagnostic-algorithm-for-human-papilloma-virus-associated-oropharyngeal-carcinoma-an-investigation-of-hpv-dna-assays
#8
Natasha Cohen, Michael Gupta, Lilian Doerwald-Munoz, Dan Jang, James Edward Massey Young, Stuart Archibald, Bernard Jackson, Jenny Lee, Max Chernesky
BACKGROUND: Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopathologic analysis. We aim to investigate the diagnostic accuracy of a new application non-histopathologic diagnostic tests to help assist diagnosis of HPV-related oropharyngeal tumors. METHODS: Patients with OPSCC with nodal metastasis were consecutively recruited from a multidisciplinary cancer clinic...
February 13, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28191672/presence-of-cutaneous-human-papillomavirus-dna-in-squamous-cell-carcinoma-of-the-scalp-a-case-series
#9
M La Placa, S Venturoli, D Barbieri, M Nocera, A Patrizi, M P Landini, P A Fanti, E Dika
Various hypotheses have been put forward on the pathogenesis of squamous cell carcinoma (SCC), including chronic sun damage and exposure to ultraviolet radiation (UVR), chemicals, smoking, immunosuppressive medications and human papillomavirus (HPV)(1) . It is well known that alpha (mucosal) HPV types, in particular HPV-16 and HPV-18, are etiologically correlated to cervical cancer and other types of anogenital carcinoma and oropharyngeal papillomatosis(1) . On the contrary, the pathogenesis of squamous cell carcinoma (SCC) outside the mucosae remains obscure, and the link with HPVs has been demonstrated only in the epidermodysplasia verruciformis context(2-3) ...
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28187443/analysis-of-the-cancer-genome-atlas-sequencing-data-reveals-novel-properties-of-the-human-papillomavirus-16-genome-in-head-and-neck-squamous-cell-carcinoma
#10
Tara J Nulton, Amy L Olex, Mikhail Dozmorov, Iain M Morgan, Brad Windle
Human papillomavirus (HPV) DNA is detected in up to 80% of oropharyngeal carcinomas (OPC) and this HPV positive disease has reached epidemic proportions. To increase our understanding of the disease, we investigated the status of the HPV16 genome in HPV-positive head and neck cancers (HNC). Raw RNA-Seq and Whole Genome Sequence data from The Cancer Genome Atlas HNC samples were analyzed to gain a full understanding of the HPV genome status for these tumors. Several remarkable and novel observations were made following this analysis...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28184239/randomized-trial-evaluating-self-sampling-for-hpv-dna-based-tests-for-cervical-cancer-screening-in-nigeria
#11
Fatima Modibbo, K C Iregbu, James Okuma, Annemiek Leeman, Annemieke Kasius, Maurits de Koning, Wim Quint, Clement Adebamowo
BACKGROUND: Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal samples for HPV DNA testing may be an effective modality that can increase uptake of cervical cancer screening in SSA and hard to reach populations in developed countries. We investigated whether self-collection of cervicovaginal samples for HPV DNA tests would be associated with increased uptake of screening compared with clinic based collection of samples...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28181989/-influence-of-age-in-the-prevalence-of-high-risk-human-papiloma-virus-in-women-with-pre-neoplasic-cervical-lesions-in-navarra-spain
#12
María Rosario Mercado Gutiérrez, Carolina Arean Cuns, María Luisa Gómez Dorronsoro, Irene Paniello Alastruey, Fermin Mallor Giménez, Maria Dolores Lozano Escario, Mercedes Santamaría Martínez
OBJECTIVE: Cervical carcinoma (CC) is the second cause of death among women aged 15 and 44 in Spain. CC is linked to hig-risk human papillomavirus (HR-HPV) infection and its prevalence varies according age and geographical region. The awereness of the latter is essential for public health prevention efforts. The aim was to study the age related in HR-HPV genotypes in cytologies with squamous intraepithelial lesion (SIL). METHODS: From a total of 67,935 ginecologic cytologies over a four-year period, we selected cytologic specimens with SIL...
9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28179315/validation-of-human-papillomavirus-as-a-favourable-prognostic-marker-and-analysis-of-cd8-tumour-infiltrating-lymphocytes-and-other-biomarkers-in-cancer-of-unknown-primary-in-the-head-and-neck-region
#13
Lars Sivars, David Landin, Nathalie Grün, Andrea Vlastos, Linda Marklund, Sushma Nordemar, Torbjörn Ramqvist, Eva Munck-Wikland, Anders Näsman, Tina Dalianis
BACKGROUND: Human papillomavirus (HPV) is a favourable prognostic factor in oropharyngeal cancer. Moreover, we and others reported that HPV-positive cancer of unknown primary in the head and neck region (HNCUP) has better outcome than HPV-negative HNCUP. However, not all studies concord. Here, our previous finding was investigated in a new cohort and additional biomarkers were analyzed. MATERIALS AND METHODS: A total of 19 HNCUPs diagnosed 2008-2013 were analyzed for HPV DNA by polymerase chain reaction assay (PCR) and p16 by immunohistochemistry (IHC)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178576/the-association-of-pre-treatment-hpv-subtypes-with-recurrence-of-vin
#14
Giorgio Bogani, Fabio Martinelli, Antonino Ditto, Mauro Signorelli, Francesca Taverna, Claudia Lombardo, Valentina Chiappa, Umberto Leone Roberti Maggiore, Dario Recalcati, Cono Scaffa, Stefania Perotto, Ilaria Sabatucci, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To assess whether pre-treatment HPV types are associated with recurrence of high-grade vulvar intraepithelial neoplasia (VIN2+). STUDY DESIGN: Data of consecutive patients with pretreatment HPV DNA test undergoing treatment for VIN2+ were retrospectively collected. Risk factors promoting the risk of VIN2+ persistence and recurrence were analyzed using Kaplan-Meier and Cox hazard proportional models. RESULTS: 64 patients had pretreatment vulvar-vaginal HPV DNA test...
February 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28178116/genital-human-papillomavirus-infection-in-indian-hiv-seropositive-men-who-have-sex-with-men
#15
Anantharam Raghavendran, Alexandra L Hernandez, Shelly Lensing, Manu Gnanamony, Rajiv Karthik, Murgesan Sivasubramanian, Rajesh Kannangai, Priya Abraham, Dilip Mathai, Joel M Palefsky
BACKGROUND: The incidence of penile cancer in Indian men is high. Little is known about genital human papillomavirus (HPV) infection in Indian HIV-seropositive men who have sex with men (MSM), a population that may be at particularly high risk for genital HPV infection and, potentially, penile cancer. In this study, we assessed the prevalence and risk factors for genital HPV infection in this population. DESIGN AND METHODS: Three hundred HIV-seropositive MSM were recruited from 2 clinical sites in India...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28174607/pitx3-dna-methylation-is-an-independent-predictor-of-overall-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#16
Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck, Dimo Dietrich
BACKGROUND: Molecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation is a frequent event in cancer and, therefore, a promising source for potential biomarkers. Here, the methylation status of the paired-like homeodomain transcription factor 3 (PITX3) was evaluated in HNSCC. METHODS: Using a quantitative real-time PCR, PITX3 methylation was assessed in a cohort of 326 HNSCC patients treated for localized or locally advanced disease (training cohort)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28171876/clinical-value-of-the-epstein-barr-virus-and-p16-status-in-patients-with-nasopharyngeal-carcinoma-a-single-centre-study-in-japan
#17
Yuki Saito, Tetsuo Ushiku, Go Omura, Kazuo Yasuhara, Masafumi Yoshida, Wataru Takahashi, Mizuo Ando, Masashi Fukayama, Tatsuya Yamasoba
BACKGROUND: The clinical significance of the Epstein-Barr virus (EBV) status and p16 expression was unknown in nasopharyngeal carcinoma (NPC). METHODS: We retrospectively studied our pathology database for 13 years to determine the prevalence of EBV and p16 expression and their association with prognosis in cases of NPC. We performed immunohistochemistry for the p16 protein and in situ hybridization (ISH) for EBV-encoded small RNAs and human papillomavirus (HPV) DNA...
February 8, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28170083/detection-of-cervical-intraepithelial-neoplasia-with-hpve6-e7-mrna-among-women-with-atypical-squamous-cells-of-unknown-significance
#18
Ya Li, Shouhua Rong, Yanfang Zhi, Cui Qiu, Tingting Fan, Xiaofu Li
OBJECTIVE: To compare E6/E7 mRNA and HPV DNA assays for evaluating women with atypical cells of undetermined significance (ASCUS). METHODS: The present prospective study enrolled patients with ASCUS undergoing HPV testing at Third Affiliated Hospital of Zhengzhou University, China, between September 1, 2013, and January 31, 2016. Patients with positive HPV DNA test results underwent screening by E6/E7 mRNA assay, and the accuracy of HPV DNA and E6/E7 mRNA testing were compared, with histology used for definitive diagnoses...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28166180/therapeutic-vaccine-against-primate-papillomavirus-infections-of-the-cervix
#19
Emeline Ragonnaud, Anne-Marie C Andersson, Silmi Mariya, Anders G Pedersen, Robert D Burk, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Alfredo Nicosia, Joko Pamungkas, Diah Iskandriati, Peter J Holst
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillomavirus (HPVs) infections, do not target all oncogenic HPVs and are insufficient to eliminate the burden of HPV induced cancer. We aim to develop an alternative HPV vaccine which is broadly effective and capable of clearing preexisting infection. In an initial attempt to develop a broadly reactive therapeutic vaccine, we designed a putative papillomavirus (PV) ancestor antigen (circulating sequence derived antigenic sequences E1E2-CDSE1E2) based on the conserved E1 and E2 protein sequences from existing oncogenic HPV strains...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28165175/possible-non-sexual-modes-of-transmission-of-human-papilloma-virus
#20
REVIEW
Sasidharanpillai Sabeena, Parvati Bhat, Veena Kamath, Govindakarnavar Arunkumar
AIM: There is strong evidence to suggest vertical and horizontal modes of transmission of human papilloma virus (HPV), an established etiologic agent of cervical cancer. Infants, children, and adults can acquire both high-risk and low-risk infections by birth or by close contact even though HPV is mainly transmitted sexually. A thorough review of the literature was performed to assess the possible non-sexual modes of transmission of HPV. METHODS: An electronic search of databases for review articles, cross-sectional studies, cohort studies, and case reports on non-sexual modes of transmission among sexually unexposed women and children was carried out using search terms such as "human papilloma virus, HPV, transmission, horizontal transmission, vertical transmission, and fomites"...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
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