keyword
https://read.qxmd.com/read/38255347/arterial-presumed-perinatal-ischemic-stroke-a-mini-review-and-case-report-of-cognitive-and-speech-language-profiles-in-a-5-year-old-girl
#21
Ivana Bogavac, Ljiljana Jeličić, Maša Marisavljević, Tatjana Bošković Matić, Miško Subotić
Arterial presumed perinatal ischemic stroke is a type of perinatal stroke that emerges due to late or delayed diagnostics of perinatal or neonatal arterial ischemic stroke. It is usually recognized before one year of life due to hemiparesis. This injury may lead to cognitive, behavioral, or motor symptoms, and life-long neurodevelopmental disabilities. In this case report, we describe a five-year-old girl with a history of arterial presumed perinatal ischemic stroke in the left hemisphere, which adversely affected her cognitive and language outcomes...
December 28, 2023: Children
https://read.qxmd.com/read/38247563/cochlear-implantation-in-children-affected-by-single-sided-deafness-a-comprehensive-review
#22
REVIEW
Giuseppe Santopietro, Virginia Fancello, Giuseppe Fancello, Chiara Bianchini, Stefano Pelucchi, Andrea Ciorba
Children with single-sided deafness (SSD) may experience delays in language and speech development. Reduced speech discrimination and poor sound localization abilities in young SSD patients may result in greater cognitive efforts required to focus and process auditory information, as well as increased listening-related fatigue. Consequently, these children can have a higher risk of academic failure and are often in need of extra help at school. Recently, cochlear implants (CIs) have been introduced as a rehabilitative option for these children, but their effectiveness is still a topic of debate...
January 12, 2024: Audiology Research
https://read.qxmd.com/read/38243045/childhood-related-neural-genotype-phenotype-in-atp1a3-mutations-comprehensive-analysis
#23
JOURNAL ARTICLE
Osama Y Muthaffar, Asma Alqarni, Jumana A Shafei, Sarah Y Bahowarth, Anas S Alyazidi, Muhammad Imran Naseer
BACKGROUND: ATP1A3 is a gene that encodes the ATPase Na + /K + transporting subunit alpha-3 isoenzyme that is widely expressed in GABAergic neurons. It maintains metabolic balance and neurotransmitter movement. These pathways are essential for the proper functioning of the nervous system. A mutation in the ATP1A3 gene demonstrates remarkable genotype-phenotype heterogeneity. OBJECTIVES: To provide insight into patients with ATP1A3 mutation...
January 19, 2024: Genes & Genomics
https://read.qxmd.com/read/38242022/developmental-skills-and-neurorehabilitation-for-children-with-batten-disease-a-retrospective-chart-review-of-a-comprehensive-batten-clinic
#24
JOURNAL ARTICLE
Rachel Bican, Virginia Goddard, Nicolas Abreu, Danielle Peifer, Andrea Basinger, Michelle Sveda, Kelly Tanner, Emily C de Los Reyes
BACKGROUND: Batten disease is a rare, progressive neurogenetic disorder composed of 13 genotypes that often presents in childhood. Children present with seizures, vision loss, and developmental regression. Neurorehabilitation services (i.e., physical therapy, occupational therapy, and speech-language therapy) can help improve the quality of life for children and their families. Owing to the rarity of Batten disease, there are no standardized clinical recommendations or outcome assessments...
March 2024: Pediatric Neurology
https://read.qxmd.com/read/38241787/primary-progressive-aphasia-and-amyotrophic-lateral-sclerosis-ppa-als-a-longitudinal-case-study
#25
JOURNAL ARTICLE
Gabrielle Hromas, Carlayne E Jackson, Douglas B Cooper, A Campbell Sullivan
OBJECTIVE: Approximately 50% of patients with amyotrophic lateral sclerosis (ALS) experience cognitive decline, with frontotemporal dementia (FTD) accounting for up to 15% of these cases. Despite this, there is considerable delay in diagnosis, which affects patient care. METHODS: We report longitudinal results of neuropsychological evaluations in a patient diagnosed with non-fluent/agrammatic primary progressive aphasia (nfvPPA) and amyotrophic lateral sclerosis (ALS)...
January 19, 2024: Applied Neuropsychology. Adult
https://read.qxmd.com/read/38239266/neurodevelopmental-profiles-of-4-year-olds-in-the-navajo-birth-cohort-study
#26
JOURNAL ARTICLE
Brandon J Rennie, Somer L Bishop, Bennett L Leventhal, Shuting Zheng, Ellen Geib, Young Shin Kim, Courtney Burnette, Emma Salzman, Sara S Nozadi, Hosanna Kim, Whitney Ence, Mina Park, Sheila Ghods, Maria Welch, Debra MacKenzie, Johnnye L Lewis
OBJECTIVE: Native American children disproportionally face many risk factors for poor developmental outcomes; these factors include poverty, environmental toxicant exposure, and limited medical, and intervention services. To understand these risks, comprehensive documentation of developmental and behavioral phenotypes are needed. In the current descriptive study, we assessed the neurodevelopment of young Diné (Navajo) children using standardized assessment instruments in combination with expert clinician judgment...
November 2023: JAACAP Open
https://read.qxmd.com/read/38227576/an-exploratory-study-of-longitudinal-trajectory-of-language-swallowing-and-cognition-post-endovascular-clot-retrieval
#27
JOURNAL ARTICLE
Pamela D'Netto, Emma Finch, Anna Rumbach, David A Copland
BACKGROUND: Endovascular clot retrieval (ECR) is known to reduce global disability at 3 months post stroke however limited research exists regarding the trajectory of specific clinical impairments including language, swallowing and cognitive deficits between onset and 3 months. AIMS: To assess language, swallowing, and cognitive performance following ECR and explore whether impairment severity is correlated with modified Thrombolysis in Cerebral Infarction score (mTICI), stroke severity or quality of life (QoL)...
January 16, 2024: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/38199865/multidimensional-analysis-of-a-social-behavior-identifies-regression-and-phenotypic-heterogeneity-in-a-female-mouse-model-for-rett-syndrome
#28
JOURNAL ARTICLE
Michael Mykins, Benjamin Bridges, Angela Jo, Keerthi Krishnan
Regression is a key feature of neurodevelopmental disorders such as Autism Spectrum Disorder, Fragile X Syndrome and Rett syndrome (RTT). RTT is caused by mutations in the X-linked gene Methyl CpG-Binding Protein 2 (MECP2). It is characterized by an early period of typical development with subsequent regression of previously acquired motor and speech skills in girls. The syndromic phenotypes are individualistic and dynamic over time. Thus far, it has been difficult to capture these dynamics and syndromic heterogeneity in the preclinical Mecp2-heterozygous female mouse model (Het)...
January 10, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38165737/the-early-subcortical-response-at-the-fundamental-frequency-of-speech-is-temporally-separated-from-later-cortical-contributions
#29
JOURNAL ARTICLE
Alina Schüller, Achim Schilling, Patrick Krauss, Tobias Reichenbach
Most parts of speech are voiced, exhibiting a degree of periodicity with a fundamental frequency and many higher harmonics. Some neural populations respond to this temporal fine structure, in particular at the fundamental frequency. This frequency-following response to speech consists of both subcortical and cortical contributions and can be measured through EEG as well as through magnetoencephalography (MEG), although both differ in the aspects of neural activity that they capture: EEG is sensitive to both radial and tangential sources as well as to deep sources, whereas MEG is more restrained to the measurement of tangential and superficial neural activity...
January 4, 2024: Journal of Cognitive Neuroscience
https://read.qxmd.com/read/38117679/developmental-delay-and-behavior-challenges-in-an-internationally-adopted-child
#30
JOURNAL ARTICLE
Lianna R Lipton, Lisa Prock, Stephen Camarata, Jason Fogler, Sarah S Nyp
Jay is a 6-year-old boy who was referred to a multidisciplinary developmental clinic for evaluation because of speech/language delays and challenging behaviors. He attends kindergarten with an Individualized Education Program (IEP) supporting developmental challenges with speech/language, motor, and academic skills.Jay was reportedly born full-term after an uneventful pregnancy and lived with his biological family for several months before transitioning to institutional care. Shortly before his first birthday, he transitioned to the first of 3 foster homes...
December 20, 2023: Journal of Developmental and Behavioral Pediatrics: JDBP
https://read.qxmd.com/read/38108348/the-reliability-and-clinical-validation-of-automatically-derived-verbal-memory-features-of-the-verbal-learning-test-in-early-diagnostics-of-cognitive-impairment
#31
JOURNAL ARTICLE
Nina Possemis, Daphne Ter Huurne, Leonie Banning, Angelique Gruters, Stephanie Van Asbroeck, Alexandra König, Nicklas Linz, Johannes Tröger, Kai Langel, Arjan Blokland, Jos Prickaerts, Marjolein de Vugt, Frans Verhey, Inez Ramakers
BACKGROUND: Previous research has shown that verbal memory accurately measures cognitive decline in the early phases of neurocognitive impairment. Automatic speech recognition from the verbal learning task (VLT) can potentially be used to differentiate between people with and without cognitive impairment. OBJECTIVE: Investigate whether automatic speech recognition (ASR) of the VLT is reliable and able to differentiate between subjective cognitive decline (SCD) and mild cognitive impairment (MCI)...
December 11, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38088821/topical-and-oral-steroids-for-otitis-media-with-effusion-ome-in-children
#32
JOURNAL ARTICLE
Caroline A Mulvaney, Kevin Galbraith, Katie E Webster, Mridul Rana, Rachel Connolly, Ben Tudor-Green, Tal Marom, Mat Daniel, Roderick P Venekamp, Anne Gm Schilder, Samuel MacKeith
BACKGROUND: Otitis media with effusion (OME) is an accumulation of fluid in the middle ear cavity, common amongst young children. The fluid may cause hearing loss. Although most episodes of OME in children resolve spontaneously within a few months, when persistent it may lead to behavioural problems and a delay in expressive language skills. Management of OME includes watchful waiting, medical, surgical and other treatments, such as autoinflation. Oral or topical steroids are sometimes used to reduce inflammation in the middle ear...
December 13, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38050025/health-supervision-for-children-and-adolescents-with-16p11-2-deletion-syndrome
#33
JOURNAL ARTICLE
Wendy K Chung, Faranak F Herrera
This clinical review is designed to assist the pediatrician, family physician or internist in caring for the child, adolescent, adult and family in whom a diagnosis of 16p11.2 deletion syndrome has been confirmed by chromosome analysis. Although a pediatrician's initial contact with the child is usually within the first 5 years of life, occasionally an adolescent or adult will be tested and diagnosed after their sibling or child has been diagnosed with the same condition. Age specific guidance for the clinician is provided in Supplement Fig 1...
December 1, 2023: Cold Spring Harbor Molecular Case Studies
https://read.qxmd.com/read/38018619/analysis-of-the-development-of-children-discharged-from-the-neonatal-intensive-care-unit-from-parents-point-of-view
#34
JOURNAL ARTICLE
Lediana Dalla Costa, Késsia Helen Dalmuth, Mayeli Thais Fernandes Vieira, Emanueli Girardi, Gisely Fachinello, Ângela Morais da Silva, Jolana Cristina Cavalheiri, Alessandro Rodrigues Perondi
OBJECTIVES: to analyze the development of children discharged from the Neonatal Intensive Care Unit and how hospitalization interferes with child development, from parents' point of view. METHODS: a descriptive-exploratory, documentary and qualitative study, carried out with parents of children discharged from the Intensive Care Unit through a telephone survey and supplementation in medical records. Data were analyzed using Bardin's tool and discussed according to scientific evidence...
2023: Revista Brasileira de Enfermagem
https://read.qxmd.com/read/38003734/molecular-characteristics-of-cisplatin-induced-ototoxicity-and-therapeutic-interventions
#35
REVIEW
Winston J T Tan, Srdjan M Vlajkovic
Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck, and lung cancer. Cisplatin is also used to treat tumors in children, such as neuroblastoma, osteosarcoma, and hepatoblastoma. However, its clinical use is limited by severe side effects, including ototoxicity, nephrotoxicity, neurotoxicity, hepatotoxicity, gastrointestinal toxicity, and retinal toxicity. Cisplatin-induced ototoxicity manifests as irreversible, bilateral, high-frequency sensorineural hearing loss in 40-60% of adults and in up to 60% of children...
November 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37998404/music-therapy-enhances-episodic-memory-in-alzheimer-s-and-mixed-dementia-a-double-blind-randomized-controlled-trial
#36
JOURNAL ARTICLE
Shirlene Vianna Moreira, Francis Ricardo Dos Reis Justi, Carlos Falcão de Azevedo Gomes, Marcos Moreira
Objective : This study aimed to assess whether a music therapy (MT) intervention could improve memory decline in older adults with and without cognitive impairment. A dual-retrieval model of episodic memory was employed to estimate memory processes. Methods : Forty-three older adults with a mean age of 76.49 years ( n = 25 with Alzheimer's disease (AD) and mixed dementia, and n = 18 healthy older adults) were randomly selected for the experimental and control groups. The study design was a double-blind randomized controlled clinical trial and a certified music therapist delivered the MT...
November 7, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37974816/cri-du-chat-syndrome-a-rare-case-report
#37
JOURNAL ARTICLE
Balaji Dhanasekaran, Rajasekaran Srinivasan, Priya Kanagamuthu, Prabakaran Somu, Namasivaya Navin R B, K Gowthame, Sarath Kumar, C Ramya Shree, S R Karthika, Greeshma U Gopan
The Cri-du-chat Syndrome (CdCs) is a rare genetic syndrome first described by Jerome Lejeune in 1963, characterized mainly by the high pitched cat like cry. The prevalence of CdCs was varied in between 1:15,000 to 1:50,000 in live birth and more common in female gender with a ratio of 4:3 [1, 2] .The condition may be accompanied by developmental and cognitive delays, poor spatial awareness, impaired ambulation, and poor sensori-motor skills. Other associated problems described include cardiovascular, renal, gastrointestinal, neurological abnormalities, preauricular tags, syndactyly, hypospadias, and cryptorchidism...
December 2023: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/37970300/hippocampal-volume-in-children-with-attention-deficit-hyperactivity-disorder-and-speech-and-language-delay
#38
JOURNAL ARTICLE
Vikas Dhikav, Manish Parakh, Kajal Pandey, Hemant Jangid, Pankaj Khicher
INTRODUCTION: Hippocampus is a complex brain structure located deep in the temporal lobes of the brain. The structure has been implicated in several disorders related to cognition. Reports are emerging of its involvement in attention deficit hyperactivity disorder (ADHD). The current study was planned to assess the volume of the hippocampus in children with ADHD and speech and language delay with normal birth history using magnetic resonance imaging (MRI) of the brain. MATERIAL AND METHODS: MRI brain of 12 children (age range = 3-6 years) and 22 controls with clinical diagnosis of ADHD as per Diagnostic and Statistical Manual-5 were obtained in oblique coronal sequence (T1 weighted)...
2023: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/37965944/ventilation-tubes-grommets-for-otitis-media-with-effusion-ome-in-children
#39
REVIEW
Samuel MacKeith, Caroline A Mulvaney, Kevin Galbraith, Katie E Webster, Rachel Connolly, Aye Paing, Tal Marom, Mat Daniel, Roderick P Venekamp, Maroeska M Rovers, Anne Gm Schilder
BACKGROUND: Otitis media with effusion (OME) is an accumulation of fluid in the middle ear cavity, common amongst young children. It may cause hearing loss which, when persistent, may lead to developmental delay, social difficulty and poor quality of life. Management includes watchful waiting, autoinflation, medical and surgical treatment. Insertion of ventilation tubes has often been used as the preferred treatment. OBJECTIVES: To evaluate the effects (benefits and harms) of ventilation tubes (grommets) for OME in children...
November 15, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37901366/validation-of-an-automated-speech-analysis-of-cognitive-tasks-within-a-semiautomated-phone-assessment
#40
JOURNAL ARTICLE
Daphne Ter Huurne, Nina Possemis, Leonie Banning, Angélique Gruters, Alexandra König, Nicklas Linz, Johannes Tröger, Kai Langel, Frans Verhey, Marjolein de Vugt, Inez Ramakers
INTRODUCTION: We studied the accuracy of the automatic speech recognition (ASR) software by comparing ASR scores with manual scores from a verbal learning test (VLT) and a semantic verbal fluency (SVF) task in a semiautomated phone assessment in a memory clinic population. Furthermore, we examined the differentiating value of these tests between participants with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). We also investigated whether the automatically calculated speech and linguistic features had an additional value compared to the commonly used total scores in a semiautomated phone assessment...
2023: Digital Biomarkers
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