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https://www.readbyqxmd.com/read/28936600/oxygen-supplementation-improves-protein-milieu-supportive-of-protein-synthesis-and-antioxidant-function-in-the-cortex-of-alzheimer-s-disease-model-mice-a-quantitative-proteomic-study
#1
Hao Wang, Xiaoyu Hong, Shuiming Li, Yong Wang
Protein synthesis has been reported to be impaired in early-stage Alzheimer's disease (AD). Previously, we found that oxygen supplementation improved cognitive function and reduced mitochondrial damage in AD model mice. In the present study, we examined the effects of supplemental oxygen treatment on protein synthesis and oxidative damage. The synthesis of numerous proteins involved in mRNA splicing, transcription regulation, and translation was found to be significantly upregulated in cortex tissues of AD model mice given a supplemental oxygen treatment (OT group), relative to those of non-treated control AD model mice (Ctrl group), suggesting that impairment in protein synthesis may be alleviated by increased oxygen inhalation...
September 21, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28936173/combining-spect-and-quantitative-eeg-analysis-for-the-automated-differential-diagnosis-of-disorders-with-amnestic-symptoms
#2
Yvonne Höller, Arne C Bathke, Andreas Uhl, Nicolas Strobl, Adelheid Lang, Jürgen Bergmann, Raffaele Nardone, Fabio Rossini, Harald Zauner, Margarita Kirschner, Amirhossein Jahanbekam, Eugen Trinka, Wolfgang Staffen
Single photon emission computed tomography (SPECT) and Electroencephalography (EEG) have become established tools in routine diagnostics of dementia. We aimed to increase the diagnostic power by combining quantitative markers from SPECT and EEG for differential diagnosis of disorders with amnestic symptoms. We hypothesize that the combination of SPECT with measures of interaction (connectivity) in the EEG yields higher diagnostic accuracy than the single modalities. We examined 39 patients with Alzheimer's dementia (AD), 69 patients with depressive cognitive impairment (DCI), 71 patients with amnestic mild cognitive impairment (aMCI), and 41 patients with amnestic subjective cognitive complaints (aSCC)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28934923/discriminative-sparse-features-for-alzheimer-s-disease-diagnosis-using-multimodal-image-data
#3
A Ortiz, F Lozano, J M Gorriz, J Ramírez, F J Martinez-Murci, For The Alzheimer S Disease Neuroimaging Initiative
BACKGROUND: Feature extraction in medical image processing still remains a challenge, especially in high-dimensionality datasets, where the expected number of available samples is considerably lower than the dimension of the feature space. This is a common problem in real-world data, and, specifically, in medical image pro- cessing as, while images are composed of hundreds of thousands voxels, only a reduced number of patients are available. OBJECTIVE: Extracting descriptive and discriminative features to represent each sample (image) by a small number of features, which is particularly important in classification task, due to the curse of dimensionality problem...
September 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28934715/stercoral-perforation-of-the-rectosigmoid-colon-due-to-chronic-constipation-a-case-report
#4
Mustafa Fevzi Celayir, Hakan Mustafa Köksal, Mehmet Uludag
INTRODUCTION: Chronic constipation is very common in elderly patients. As a result of this situation fecaloma is also frequently seen at these ages. However, the stercoral perforation caused by fecaloma is a rare situation to occur. The rectosigmoid colon is the most affected colonic segment. It is seen in older patients with concomitant diseases and a low quality of life. PRESENTATION OF CASE: Here in this case, we have to report an 83 - year-old male patient who came to the emergency room with complaints of abdominal pain and constipation for two days...
September 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28934394/microrna-455-3p-as-a-potential-peripheral-biomarker-for-alzheimer-s-disease
#5
Subodh Kumar, Murali Vijayan, P Hemachandra Reddy
The purpose of our study was to identify microRNAs (miRNAs) as early detectable peripheral biomarkers in Alzheimer's disease (AD). To achieve our objective, we assessed miRNAs in serum samples from AD patients and Mild cognitive impairment (MCI) subjects relative to healthy controls. We used Affymetrix microarray analysis and validated differentially expressed miRNAs using qRT-PCR. We further validated miRNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell lines. We identified a gradual upregulation of four miRNAs: miR-455-3p, miR-4668-5p, miR-3613-3p and miR-4674...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28933985/acn-1-a-c-elegans-homologue-of-ace-genetically-interacts-with-the-let-7-microrna-and-other-heterochronic-genes
#6
Chanatip Metheetrairut, Yuri Ahuja, Frank J Slack
The heterochronic pathway in C. elegans controls the relative timing of cell fate decisions during post-embryonic development. It includes a network of microRNAs (miRNAs), such as let-7, and protein-coding genes, such as the stemness factors, LIN-28 and LIN-41. Here we identified the acn-1 gene, a homologue of mammalian angiotensin-converting enzyme (ACE), as a new suppressor of the stem cell developmental defects of let-7 mutants. Since acn-1 null mutants die during early larval development, we used RNAi to characterize the role of acn-1 in C...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28932758/iterative-image-processing-for-early-diagnostic-of-beta-amyloid-plaque-deposition-in-pre-clinical-alzheimer-s-disease-studies
#7
Nikolai V Slavine, Padmakar V Kulkarni, Roderick W McColl
PURPOSE: To test and evaluate an efficient iterative image processing strategy to improve the quality of sub-optimal pre-clinical PET images. A novel iterative resolution subsets-based method to reduce noise and enhance resolution (RSEMD) has been demonstrated on examples of PET imaging studies of Alzheimer's disease (AD) plaques deposition in mice brains. MATERIALS AND METHODS: The RSEMD method was applied to imaging studies of non-invasive detection of beta-amyloid plaque in transgenic mouse models of AD...
August 2017: Journal of Applied Bioinformatics & Computational Biology
https://www.readbyqxmd.com/read/28930619/asiatic-acid-nullified-aluminium-toxicity-in-in-vitro-model-of-alzheimer-s-disease
#8
Mashoque Ahmad Rather, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Jegadeesan Nataraj, Musthafa Mohamed Essa, Saravana Babu Chidambaram
Aluminium (Al) is a ubiquitously distributed environmental toxicant that lacks biological functions; however, its accumulation in the brain has been demonstrated to be linked to several neuropathological conditions particularly Alzheimer's disease (AD). Asiatic acid (AA), a triterpene extracted from Centella asiatica, has been reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. The present study was aimed to explore the neuroprotective effect of AA against aluminium maltolate (Al(mal)3) induced neurotoxicity by assessing cell viability, mitochondrial membrane potential, levels of reactive oxygen species (ROS), DNA damage and apoptosis (Hoechst and dual staining, comet assay; expressions of pro-apoptotic, anti-apoptotic and signaling indices) via AKT/GSK-3β signaling pathway in SH-SY 5Y  neuroblastoma cells...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930599/dissection-of-prodromal-alzheimer-s-disease
#9
Can Sheng, Yue Huang, Ying Han
Pathophysiological changes of Alzheimer's Disease (AD) begin decades before clinical symptoms become apparent, providing an important window for early diagnosis and intervention. Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention. The application of different biomarkers including neuroimaging, biochemical substances and genes makes AD-related pathology detectable in vivo and exploring novel biomarkers with relatively non-invasive and low cost has intrigued a wide range of interests...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930568/medical-imaging-diagnosis-of-early-alzheimer-s-disease
#10
Fatma El-Zahraa A El-Gamal, Mohammed M Elmogy, Mohammed Ghazal, Ahmed Atwan, Manual F Casanova, Gregory N Barnes, Ayman El-Baz, Hassan Hajjdiab
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases that influences the central nervous system, often leading to dire consequences for quality of life. The disease goes through some stages mainly divided into early, moderate, and severe. Among them, the early stage is the most important as medical intervention has the potential to alter the natural progression of the condition. In practice, the early diagnosis is a challenge since the neurodegenerative changes can precede the onset of clinical symptoms by 10-15 years...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930562/alzheimer-s-disease-diagnostics-by-a-3d-deeply-supervised-adaptable-convolutional-network
#11
Ehsan Hosseini-Asl, Mohammed Ghazal, Ali Mahmoud, Ali Aslantas, Ahmed M Shalaby, Manual F Casanova, Gregory N Barnes, Georgy Gimel'farb, Robert Keynton, Ayman El-Baz
Early diagnosis is playing an important role in preventing progress of the Alzheimer's disease (AD). This paper proposes to improve the prediction of AD with a deep 3D Convolutional Neural Network (3D-CNN), which can show generic features capturing AD biomarkers extracted from brain images, adapt to different domain datasets, and accurately classify subjects with improved fine-tuning method. The 3D-CNN is built upon a convolutional autoencoder, which is pre-trained to capture anatomical shape variations in structural brain MRI scans for source domain...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930543/eeg-and-erp-biomarkers-of-alzheimer-s-disease-a-critical-review
#12
Andras Horvath, Anna Szucs, Gabor Csukly, Anna Sakovics, Gabor Stefanics, Anita Kamondi
Here we critically review studies that used electroencephalography (EEG) or event-related potential (ERP) indices as a biomarker of Alzheimer's disease. In the first part we overview studies that relied on visual inspection of EEG traces and spectral characteristics of EEG. Second, we survey analysis methods motivated by dynamical systems theory (DST) as well as more recent network connectivity approaches. In the third part we review studies of sleep.  Next, we compare the utility of early and late ERP components in dementia research...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28928628/axonal-degeneration-during-aging-and-its-functional-role-in-neurodegenerative-disorders
#13
REVIEW
Natalia Salvadores, Mario Sanhueza, Patricio Manque, Felipe A Court
Aging constitutes the main risk factor for the development of neurodegenerative diseases. This represents a major health issue worldwide that is only expected to escalate due to the ever-increasing life expectancy of the population. Interestingly, axonal degeneration, which occurs at early stages of neurodegenerative disorders (ND) such as Alzheimer's disease, Amyotrophic lateral sclerosis, and Parkinson's disease, also takes place as a consequence of normal aging. Moreover, the alteration of several cellular processes such as proteostasis, response to cellular stress and mitochondrial homeostasis, which have been described to occur in the aging brain, can also contribute to axonal pathology...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28926672/everyday-decision-making-in-individuals-with-early-stage-alzheimer-s-disease-an-integrative-review-of-the-literature
#14
Rebecca Davis, Mary K Ziomkowski, Amy Veltkamp
Individuals with Alzheimer's disease (AD) demonstrate fluctuation in cognitive abilities that can affect their ability to make decisions. Everyday decision making encompasses the types of decisions about typical daily activities, such as what to eat, what to do, and what to wear. Everyday decisions are encountered many times per day by individuals with AD/dementia and their caregivers. However, not much is known about the ability of individuals with AD/dementia to make these types of decisions. The purpose of the current literature review was to synthesize the evidence regarding everyday decision making in individuals with early-stage AD/dementia...
September 1, 2017: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/28923553/a-systematic-integrated-analysis-of-brain-expression-profiles-reveals-yap1-and-other-prioritized-hub-genes-as-important-upstream-regulators-in-alzheimer-s-disease
#15
Min Xu, Deng-Feng Zhang, Rongcan Luo, Yong Wu, Hejiang Zhou, Li-Li Kong, Rui Bi, Yong-Gang Yao
INTRODUCTION: Profiling the spatial-temporal expression pattern and characterizing the regulatory networks of brain tissues are vital for understanding the pathophysiology of Alzheimer's disease (AD). METHODS: We performed a systematic integrated analysis of expression profiles of AD-affected brain tissues (684 AD and 562 controls). A network-based convergent functional genomic approach was used to prioritize possible regulator genes during AD development, followed by functional characterization...
September 15, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28923392/mitochondrial-depletion-in-cd4-and-cd19-peripheral-lymphocytes-in-early-stage-alzheimer-s-disease
#16
Gökhan Terzioğlu, Burcu Örmeci, Özlem Türksoy, Ceyhun Sayman, Nilgün Çınar, Gökçen Akar Öztürk, Gülderen Yanıkkaya Demirel
Alzheimer's disease (AD) may be associated with mitochondrial defects. The aim of the present study was to investigate changes in mitochondrial abundance in peripheral lymphocytes of early and late stage AD patients. We analysed levels of mitochondrial DNA (mtDNA) and mean fluorescence intensity (MFI) of the mitochondria-specific antibody 113-1 in CD4(+), CD8(+), CD19(+) and CD56(+) peripheral lymphocytes of early and late stage AD by quantitative real-time PCR and flow cytometry, respectively. In early stage AD, the levels of mtDNA were significantly decreased in CD4(+), CD19(+) and CD56(+) peripheral lymphocytes while the MFI of 113-1 staining was significantly decreased in CD4(+) and CD19(+) cells...
September 18, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28922156/soluble-oligomers-require-a-ganglioside-to-trigger-neuronal-calcium-overload
#17
Roberta Cascella, Elisa Evangelisti, Alessandra Bigi, Matteo Becatti, Claudia Fiorillo, Massimo Stefani, Fabrizio Chiti, Cristina Cecchi
An altered distribution of membrane gangliosides (GM), including GM1, has recently been reported in the brains of Alzheimer's disease (AD) patients. Moreover, amyloid-positive synaptosomes obtained from AD brains were found to contain high-density GM1 clusters, suggesting a pathological significance of GM1 increase at presynaptic neuritic terminals in AD. Here, we show that membrane GM1 specifically recruits small soluble oligomers of the 42-residue form of amyloid-β peptide (Aβ42), with intracellular flux of Ca2+ ions in primary rat hippocampal neurons and in human neuroblastoma cells...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922152/brain-biomarkers-in-familial-alzheimer-s-disease-mouse-models
#18
Yafit Kuttner-Hirshler, Palamadai N Venkatasubramanian, Joan Apolinario, Jacqueline Bonds, Alice M Wyrwicz, Orly Lazarov
Alzheimer's disease (AD) is characterized by progressive loss of memory and cognitive deterioration. It is thought that the onset of the disease takes place several decades before memory deficits are apparent. Reliable biomarkers for the diagnosis or prognostication of the disease are highly desirable. Neural stem cells (NSC) exist in the adult brain throughout life and give rise to neural progenitor cells (NPC), which differentiate into neurons or glia. The level of NPC proliferation and new neuron formation is significantly compromised in mouse models of familial Alzheimer's disease (FAD)...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28921979/design-syntheses-and-in-vitro-evaluation-of-new-fluorine-18-radiolabeled-tau-labeling-molecular-probes
#19
Luka Rejc, Lojze Šmid, Vladimir Kepe, Črtomir Podlipnik, Amalija Golobič, Mara Bresjanac, Jorge R Barrio, Andrej Petrič, Janez Košmrlj
Deposition of aggregates of hyperphosphorylated tau protein is a hallmark of tauopathies like Alzheimer and many other neurodegenerative diseases. A sensitive and selective method of in vivo detection of tau-aggregate presence and distribution could provide the means of an early diagnosis of tau-associated diseases. Furthermore, the use of selective molecular probes that enable histochemical differentiation of protein aggregates post mortem would be advantageous for the insight into the properties of tau protein aggregates...
September 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28920532/the-impact-of-traumatic-brain-injury-on-later-life-effects-on-normal-aging-and-neurodegenerative-diseases
#20
Grace Sophia Griesbach, Brent E Masel, Richard Edward Helvie, Mark Ashley
The acute and chronic effects of traumatic brain injury (TBI) have been widely described; however, there is limited knowledge on how a TBI sustained during early or mid adulthood will influence aging. Epidemiological studies have explored whether TBI poses a risk for dementia and other neurodegenerative diseases associated with aging. We will discuss the influence of TBI and resulting medical comorbidities such as endocrine, sleep and inflammatory disturbances on age-related grey and white matter changes and cognitive decline...
September 16, 2017: Journal of Neurotrauma
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