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https://www.readbyqxmd.com/read/29031061/crassiflorone-derivatives-that-inhibit-trypanosoma-brucei-glyceraldehyde-3-phosphate-dehydrogenase-tbgapdh-and-trypanosoma-cruzi-trypanothione-reductase-tctr-and-display-trypanocidal-activity
#1
Elisa Uliassi, Giulia Fiorani, R Luise Krauth-Siegel, Christian Bergamini, Romana Fato, Giulia Bianchini, J Carlos Menéndez, Maria Teresa Molina, Eulogio López-Montero, Federico Falchi, Andrea Cavalli, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Gesa Witt, Carolina B Moraes, Lucio H Freitas-Junior, Chiara Borsari, Maria Paola Costi, Maria Laura Bolognesi
Crassiflorone is a natural product with anti-mycobacterial and anti-gonorrhoeal properties, isolated from the stem bark of the African ebony tree Diospyros crassiflora. We noticed that its pentacyclic core possesses structural resemblance to the quinone-coumarin hybrid 3, which we reported to exhibit a dual-targeted inhibitory profile towards Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR). Following this basic idea, we synthesized a small library of crassiflorone derivatives 15-23 and investigated their potential as anti-trypanosomatid agents...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029171/effect-of-hiv-on-the-frequency-and-number-of-mycobacterium-tuberculosis-specific-cd4-t-cells-in-blood-and-the-airways-in-latent-tuberculosis-infection
#2
Rubina Bunjun, Catherine Riou, Andreia P Soares, Narjis Thawer, Tracey L Müller, Agano Kiravu, Zekarias Ginbot, Tolu Oni, Rene Goliath, Barbara Kalsdorf, Florian von Groote-Bidlingmaier, Willem Hanekom, Gerhard Walzl, Robert J Wilkinson, Wendy A Burgers
HIV-1 infection substantially increases the risk of developing tuberculosis (TB). There is extensive depletion of Mycobacterium tuberculosis (M.tuberculosis)-specific CD4+ T cells in blood in early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4 destruction, we investigated M.tuberculosis-specific responses in bronchoalveolar lavage (BAL), in persons with latent TB infection and untreated HIV-1 co-infection with preserved CD4 counts...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028148/follow-up-of-1887-patients-receiving-tumor-necrosis-alpha-antagonists-tuberculin-skin-test-conversion-and-tuberculosis-risk
#3
Tulin Cagatay, Zuleyha Bingol, Esen Kıyan, Zeynep Yegin, Gulfer Okumus, Orhan Arseven, Feyza Erkan, Ziya Gulbaran, Mustafa Erelel, Turhan Ece, Penbe Cagatay', Zeki Kılıçaslan
OBJECTIVES: To evaluate the characteristics of patients who developed tuberculosis while receiving tumor necrosis factor-alpha (TNF-α) antagonists and the related factors with tuberculosis. METHODS: Patient's demographics, tuberculin skin test (TST), isoniazid prophylaxis, type of TNF-α antagonist were recorded. TST conversion (>5mm increase) was evaluated for patients who had baseline and 1-year TST. RESULTS: Files of 1887 patients who were receiving TNF-α antagonists between August2005 and June 2015 were evaluated...
October 13, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29026882/efficient-measurement-and-factorization-of-high-order-drug-interactions-in-mycobacterium-tuberculosis
#4
Murat Cokol, Nurdan Kuru, Ece Bicak, Jonah Larkins-Ford, Bree B Aldridge
Combinations of three or more drugs are used to treat many diseases, including tuberculosis. Thus, it is important to understand how synergistic or antagonistic drug interactions affect the efficacy of combination therapies. However, our understanding of high-order drug interactions is limited because of the lack of both efficient measurement methods and theoretical framework for analysis and interpretation. We developed an efficient experimental sampling and scoring method [diagonal measurement of n-way drug interactions (DiaMOND)] to measure drug interactions for combinations of any number of drugs...
October 2017: Science Advances
https://www.readbyqxmd.com/read/29026615/an-unusual-cutaneous-infection-caused-by-mycobacterium-marinum
#5
Federica Veronese, Elisa Zavattaro, Pamela Farinelli, Enrico Colombo, Paola Savoia
Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026492/chronic-large-non-healing-ulcer-non-tuberculous-mycobacterial-infection-of-the-laryngopharynx
#6
Nurfarissa Hussin, Marina Mat Baki, Abdullah Sani
We describe a case of non-tuberculous mycobacterial infection of the larynx in a previously well, immunocompetent young woman. Laryngeal mycobacterial infection is rare and currently accounts for less than 1% of all cases. A diagnostic dilemma often occurs because it may mimic laryngeal carcinoma, chronic laryngitis, or laryngeal candidiasis. This case highlights the importance of considering non-tuberculous mycobacterial infection in the differential diagnosis of laryngeal lesions.
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29025965/inherited-il-12r%C3%AE-1-deficiency-in-a-child-with-bcg-adenitis-and-oral-candidiasis-a-case-report
#7
Nevin Hatipoglu, B Haluk Güvenç, Caroline Deswarte, Kaya Koksalan, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, Jacinta Bustamante
Tuberculosis is a major worldwide problem, and protection from it is achieved mainly by live attenuated bacille Calmette-Guérin vaccine, which is capable of causing disease in immunocompromised host. Oral thrush is abnormal in healthy children, which suggests an underlying immunodeficiency. Mendelian susceptibility to mycobacterial disease is a rare primary immunodeficiency characterized by a selective predisposition to weakly virulent Mycobacteria and Salmonella and also predisposition to chronic mucocutaneous candidiasis...
October 12, 2017: Pediatrics
https://www.readbyqxmd.com/read/29025941/draft-genome-sequence-of-a-rare-pigmented-mycobacterium-avium-subsp-paratuberculosis-type-c-strain
#8
Pedro Barbosa, Célia Leão, Anabel Usié, Ana Amaro, Ana Botelho, Carlos Pinto, João Inácio, Karen Stevenson, António Marcos Ramos
Mycobacterium avium subsp. paratuberculosis is the causative agent of paratuberculosis. We report here the draft genome sequence of a rare pigmented M. avium subsp. paratuberculosis type C strain, comprising 58 contigs and having a genome size of 4,851,414 bp. The genome will assist in the execution of pigmentation and virulence studies on this mycobacterium.
October 12, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29024967/atypical-macrophages-in-disseminated-mycobacterium-intracellulare-infection
#9
Zhiliang Hu, Xingguo Lu, Xudong Shi, Hongxia Wei
No abstract text is available yet for this article.
August 24, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29023399/novel-anti-tuberculosis-nanodelivery-formulation-of-ethambutol-with-graphene-oxide
#10
Bullo Saifullah, Alina Chrzastek, Arundhati Maitra, Bullo Naeemullah, Sharida Fakurazi, Sanjib Bhakta, Mohd Zobir Hussein
Tuberculosis (TB) is a bacterial disease responsible for millions of infections and preventable deaths each year. Its treatment is complicated by patients' noncompliance due to dosing frequency, lengthy treatment, and adverse side effects associated with current chemotherapy. However, no modifications to the half-a-century old standard chemotherapy have been made based on a nanoformulation strategy to improve pharmacokinetic efficacy. In this study, we have designed a new nanodelivery formulation, using graphene oxide as the nanocarrier, loaded with the anti-TB antibiotic, ethambutol...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022243/pyrosequencing-analysis-of-source-water-switch-and-sulfate-induced-bacterial-community-transformation-in-simulated-drinking-water-distribution-pipes
#11
Fan Yang, Baoyou Shi, Weiyu Zhang, Jing Cui, Jianbo Guo, Dongsheng Wang, Nan Wu, Xinyuan Liu
Inter-basin water transfer and source water switching will be increasingly launched due to significant population increase and the shortage of the local water resources in cities around the world. Source water switch may cause physiochemical and microbiological de-stabilization of pipe material, biofilms, and loose deposits in drinking water distribution system (DWDS). Great sulfate alteration during source water switch had been deemed as the main cause of a red water case that occurred in a northern China city...
October 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29022194/potential-for-cometabolic-biodegradation-of-1-4-dioxane-in-aquifers-with-methane-or-ethane-as-primary-substrates
#12
Paul B Hatzinger, Rahul Banerjee, Rachael Rezes, Sheryl H Streger, Kevin McClay, Charles E Schaefer
The objective of this research was to evaluate the potential for two gases, methane and ethane, to stimulate the biological degradation of 1,4-dioxane (1,4-D) in groundwater aquifers via aerobic cometabolism. Experiments with aquifer microcosms, enrichment cultures from aquifers, mesophilic pure cultures, and purified enzyme (soluble methane monooxygenase; sMMO) were conducted. During an aquifer microcosm study, ethane was observed to stimulate the aerobic biodegradation of 1,4-D. An ethane-oxidizing enrichment culture from these samples, and a pure culture capable of growing on ethane (Mycobacterium sphagni ENV482) that was isolated from a different aquifer also biodegraded 1,4-D...
October 11, 2017: Biodegradation
https://www.readbyqxmd.com/read/29022045/author-correction-molecular-basis-of-mycobacterial-survival-in-macrophages
#13
Jane Atesoh Awuh, Trude Helen Flo
One of the author affiliations was missed to include in the original publication. The correct information is given below.
October 11, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29021977/the-consensus-from-the-mycobacterium-avium-ssp-paratuberculosis-map-conference-2017
#14
J Todd Kuenstner, Saleh Naser, William Chamberlin, Thomas Borody, David Y Graham, Adrienne McNees, John Hermon-Taylor, Amy Hermon-Taylor, C Thomas Dow, Walter Thayer, James Biesecker, Michael T Collins, Leonardo A Sechi, Shoor Vir Singh, Peilin Zhang, Ira Shafran, Stuart Weg, Grzegorz Telega, Robert Rothstein, Harry Oken, Stephen Schimpff, Horacio Bach, Tim Bull, Irene Grant, Jay Ellingson, Heinrich Dahmen, Judith Lipton, Saurabh Gupta, Kundan Chaubey, Manju Singh, Prabhat Agarwal, Ashok Kumar, Jyoti Misri, Jagdip Sohal, Kuldeep Dhama, Zahra Hemati, William Davis, Michael Hier, John Aitken, Ellen Pierce, Nicole Parrish, Neil Goldberg, Maher Kali, Sachin Bendre, Gaurav Agrawal, Robert Baldassano, Preston Linn, Raymond W Sweeney, Marie Fecteau, Casey Hofstaedter, Raghava Potula, Olga Timofeeva, Steven Geier, Kuruvilla John, Najah Zayanni, Hoda M Malaty, Christopher Kahlenborn, Amanda Kravitz, Adriano Bulfon, George Daskalopoulos, Hazel Mitchell, Brett Neilan, Verlaine Timms, Davide Cossu, Giuseppe Mameli, Paul Angermeier, Tomislav Jelic, Ralph Goethe, Ramon A Juste, Lauren Kuenstner
On March 24 and 25, 2017 researchers and clinicians from around the world met at Temple University in Philadelphia to discuss the current knowledge of Mycobacterium avium ssp. paratuberculosis (MAP) and its relationship to human disease. The conference was held because of shared concern that MAP is a zoonotic bacterium that poses a threat not only to animal health but also human health. In order to further study this problem, the conferees discussed ways to improve MAP diagnostic tests and discussed potential future anti-MAP clinical trials...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29021791/cofactor-tail-length-modulates-catalysis-of-bacterial-f420-dependent-oxidoreductases
#15
Blair Ney, Carlo R Carere, Richard Sparling, Thanavit Jirapanjawat, Matthew B Stott, Colin J Jackson, John G Oakeshott, Andrew C Warden, Chris Greening
F420 is a microbial cofactor that mediates a wide range of physiologically important and industrially relevant redox reactions, including in methanogenesis and tetracycline biosynthesis. This deazaflavin comprises a redox-active isoalloxazine headgroup conjugated to a lactyloligoglutamyl tail. Here we studied the catalytic significance of the oligoglutamate chain, which differs in length between bacteria and archaea. We purified short-chain F420 (two glutamates) from a methanogen isolate and long-chain F420 (five to eight glutamates) from a recombinant mycobacterium, confirming their different chain lengths by HPLC and LC/MS analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29021638/real-time-pcr-assay-for-the-diagnosis-of-pleural-tuberculosis
#16
Martha Alejandra Casallas-Rivera, Ana María Cárdenas Bernal, Luis Fernando Giraldo-Cadavid, Enrique Prieto Diago, Sandra Paola Santander
INTRODUCTION: The diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak. OBJECTIVE: To establish the operating characteristics of real-time polymerase chain reaction (RT-PCR) hybridization probes for the diagnosis of pleural tuberculosis. METHODS: The validity of the RT-PCR hybridization probes was evaluated compared to a composite reference method by a cross-sectional study at the Hospital Universitario de la Samaritana...
June 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29021523/high-fidelity-dna-replication-in-mycobacterium-tuberculosis-relies-on-a-trinuclear-zinc-center
#17
Soledad Baños-Mateos, Anne-Marie M van Roon, Ulla F Lang, Sarah L Maslen, J Mark Skehel, Meindert H Lamers
High-fidelity DNA replication depends on a proofreading 3'-5' exonuclease that is associated with the replicative DNA polymerase. The replicative DNA polymerase DnaE1 from the major pathogen Mycobacterium tuberculosis (Mtb) uses its intrinsic PHP-exonuclease that is distinct from the canonical DEDD exonucleases found in the Escherichia coli and eukaryotic replisomes. The mechanism of the PHP-exonuclease is not known. Here, we present the crystal structure of the Mtb DnaE1 polymerase. The PHP-exonuclease has a trinuclear zinc center, coordinated by nine conserved residues...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29021481/cryptococcal-pleuritis-presenting-with-lymphocyte-predominant-and-high-levels-of-adenosine-deaminase-in-pleural-effusions-coincident-with-pulmonary-tuberculosis
#18
Yoshitomo Kushima, Hidenori Takizawa, Yasutaka Machida, Takafumi Umetsu, Naoya Ikeda, Masaaki Miyoshi, Kazuyuki Chibana, Yasuo Shimizu, Akihiro Takemasa, Yoshiki Ishii
Co-infection with cryptococcus and tuberculosis has rarely been reported. We herein report a case of an 80-year-old man with cryptococcal pleuritis concurrent with pulmonary tuberculosis. He was admitted for progression of left pleural effusion and consolidation in the left upper lobe. Culture for Mycobacterium tuberculosis was positive in sputum, and analyses of pleural effusion revealed lymphocyte-predominant high levels of adenosine deaminase (ADA). Medical thoracoscopy revealed massive infiltration of Cryptococcus neoformans in pleura without granuloma...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29020922/a-multiple-genome-analysis-of-mycobacterium-tuberculosis-reveals-specific-novel-genes-and-mutations-associated-with-pyrazinamide-resistance
#19
Patricia Sheen, David Requena, Eduardo Gushiken, Robert H Gilman, Ricardo Antiparra, Bryan Lucero, Pilar Lizárraga, Basilio Cieza, Elisa Roncal, Louis Grandjean, Arnab Pain, Ruth McNerney, Taane G Clark, David Moore, Mirko Zimic
BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its complete mechanism of action and resistance remains unclear. RESULTS: We genotyped and sequenced the complete genomes of 68 M. tuberculosis strains isolated from unrelated TB patients in Peru. No clustering pattern of the strains was verified based on spoligotyping...
October 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29020319/tuberculosis-case-finding-with-combined-rapid-point-of-care-assays-xpert%C3%A2-mtb-rif-and-lam-in-hiv-positive-individuals-starting-antiretroviral-treatment-in-mozambique
#20
Marco Floridia, Fausto Ciccacci, Mauro Andreotti, Archa Hassane, Zita Sidumo, Nurja A Magid, Horacio Sotomane, Muhlavasse David, Elsa Mutemba, Junia Cebola, Remigio Josè Mugunhe, Fabio Riccardi, Maria Cristina Marazzi, Marina Giuliano, Leonardo Palombi, Sandro Mancinelli
Background: Tuberculosis (TB) is a major health concern in several countries, and effective diagnostic algorithms in HIV+ patients are urgently needed. Methods: At prescription of antiretroviral therapy (ART), all patients of three Mozambican health centres were screened for TB, with a combined approach: the WHO 4-symptom screening (fever, cough, night sweats, weight loss) (WHO-4SS), a rapid test detecting mycobacterial lipoarabinomannan in urine (LAM), and a molecular assay on sputum (Xpert® MTB/RIF, repeated if first result was negative)...
July 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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