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https://www.readbyqxmd.com/read/29220797/primaquine-hybrids-as-promising-antimycobacterial-and-antimalarial-agents
#1
Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Four series of primaquine (PQ) derivatives were screened for antitubercular and antiplasmodial activity: amides 1a-k, ureas 2a-s, semicarbazides 3a-c and bis-ureas 4a-u. Antimycobacterial activity of PQ derivatives against Mycobacterium tuberculosis (MTB), M. avium complex (MAC) and M. avium subsp. paratuberculosis (MAP) were evaluated in vitro and compared with PQ and the standard antitubercular drugs. In general, the PQ derivatives showed higher potency than the parent compound. Most of the compounds of series 1 and 2 showed high activity against MAP, comparable or even higher than the relevant drug ciprofloxacin, and weak or no activity against MTB and MAC...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220433/tible-a-web-based-freely-accessible-resource-for-small-molecule-binding-data-for-mycobacterial-species
#2
Sony Malhotra, Grace Mugumbate, Tom L Blundell, Alicia P Higueruelo
http://www-cryst.bioc.cam.ac.uk/tible/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29218640/oxoiron-iv-complexes-as-synthons-for-the-assembly-of-heterobimetallic-centers-such-as-the-fe-mn-active-site-of-class-ic-ribonucleotide-reductases
#3
Ang Zhou, Patrick M Crossland, Apparao Draksharapu, Andrew J Jasniewski, Scott T Kleespies, Lawrence Que
Nonheme oxoiron(IV) complexes can serve as synthons for generating heterobimetallic oxo-bridged dimetal complexes by reaction with divalent metal complexes. The formation of FeIII-O-CrIII and FeIII-O-MnIII complexes is described herein. The latter complexes may serve as models for the FeIII-X-MnIII active sites of an emerging class of Fe/Mn enzymes represented by the Class 1c ribonucleotide reductase from Chlamydia trachomatis and the R2-like ligand-binding oxidase (R2lox) found in Mycobacterium tuberculosis...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218036/the-macrophage-a-disputed-fortress-in-the-battle-against-mycobacterium-tuberculosis
#4
REVIEW
Christophe J Queval, Roland Brosch, Roxane Simeone
Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has plagued humans for thousands of years. TB still remains a major public health problem in our era, causing more than 4,400 deaths worldwide every day and killing more people than HIV. After inhaling Mtb-contaminated aerosols, TB primo-infection starts in the terminal lung airways, where Mtb is taken up by alveolar macrophages. Although macrophages are known as professional killers for pathogens, Mtb has adopted remarkable strategies to circumvent host defenses, building suitable conditions to survive and proliferate...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29217910/primary-tubercular-abscess-of-the-axilla-a-rare-case
#5
Ameet Kumar, T S Ramakrishnan, Samaresh Sahu
Tuberculosis can be broadly classified as pulmonary and extrapulmonary. Though pulmonary tuberculosis is the most common presentation, extrapulmonary tuberculosis is also an important entity. A tubercular cold abscess secondary to involvement of an adjacent bone or suppuration of lymph nodes is a well-known entity; however, a primary cold abscess is rare. We report a case of a young girl who presented with an axillary swelling which turned out to be a primary tubercular abscess of the axilla. To the best of our knowledge, this is the first reported case of a primary tubercular abscess presenting in the axilla...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29217890/nontubercular-mycobacterial-infection-in-a-renal-allograft-recipient
#6
U Anandh, K Jayanna
A 71-year-old male, a renal allograft recipient, presented to us with a history of fever and right palm swelling. He had a history of fever 7 years back when he was treated with antitubercular treatment (ATT). Three years back, he was diagnosed to have gout and he was started on allopurinol. He developed severe bone marrow toxicity and allopurinol was changed to febuxostat. On admission, routine investigations did not reveal any focus of infection. The fluid aspirate from the palm revealed acid-fast bacilli (AFB)...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29217790/genome-sequences-of-mycobacteriophages-amgine-amohnition-bella96-cain-darthp-hammy-krueger-lasthope-peanam-phelpsodu-phrank-sirphilip-slimphazie-and-unicorn
#7
Kirk R Anders, Nazir Barekzi, Aaron A Best, Gregory D Frederick, Dmitri V Mavrodi, Edwin Vazquez, Nana Yaa A Amoh, Frederick N Baliraine, William J Buchser, Thomas P Cast, Carmen E Chamberlain, Hui-Min Chung, William A D'Angelo, Christian T Farris, Mariceli Fernandez-Martinez, Haley D Fischman, Mark H Forsyth, Anna G Fortier, Kara F Gallo, Greta J Held, Miguel A Lomas, Natalia Y Maldonado-Vazquez, Claudia H Moonsammy, Peace Namboote, Sudip Paudel, Sarah-Elizabeth M Polley, Gabriella M Reyes, Michael R Rubin, Margaret S Saha, Joseph Stukey, Tristan D Tobias, Rebecca A Garlena, Ty H Stoner, Steven G Cresawn, Deborah Jacobs-Sera, Welkin H Pope, Daniel A Russell, Graham F Hatfull
We report the genome sequences of 14 cluster K mycobacteriophages isolated using Mycobacterium smegmatis mc²155 as host. Four are closely related to subcluster K1 phages, and 10 are members of subcluster K6. The phage genomes span considerable sequence diversity, including multiple types of integrases and integration sites.
December 7, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29217637/how-t-cells-grasp-mycobacterial-lipid-antigens
#8
D Branch Moody
No abstract text is available yet for this article.
December 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29217612/mycobacterium-tuberculosis-of-the-elbow-joint
#9
Quintin Liao, James George Shepherd, Sulman Hasnie
Mycobacterium tuberculosis(TB) affecting the elbow joint is rarely reported in the developed world. We present the case of an 85-year-old Caucasian female who complained of a chronically discharging and painful wound across her left elbow during her admission for an ischaemic stroke. This was initially deemed to be either a bursitis or local manifestation of amyloid by her general practitioner and dermatologist respectively prior to admission. She was commenced on flucloxacillin by the medical team for presumed cellulitis with minimal response...
December 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29217419/in-vitro-activity-of-tedizolid-against-the-mycobacterium-abscessus-complex
#10
Fabrice Compain, Daria Soroka, Beate Heym, Jean-Louis Gaillard, Jean-Louis Herrmann, Delphine Dorchène, Michel Arthur, Vincent Dubée
Infections due to Mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics. Here, we evaluate the in vitro activity of the new oxazolidinone tedizolid against a collection of 44M. abscessus clinical isolates. The MIC50s and MIC90s of tedizolid (2 and 8μg/mL, respectively) were 2- to 16-fold lower than those of linezolid. There was no difference between the 3M. abscessus subspecies. Time-kill assays did not show any bactericidal activity at 4- and 8-fold the MIC...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29217277/absence-of-hybridization-with-the-wild-type-and-mutant-rpob-probes-in-the-genotype-mtbdrplus-assay-detects-disputed-rifampicin-mutations
#11
Ngu Njei Abanda, Josiane Yvonne Djieugoué, Vedbar S Khadka, Eric Walter Pefura-Yone, Wilfred Fon Mbacham, Guy Vernet, Veronique Mbeng Penlap, Youping Deng, Sara Irene Eyangoh, Diane Wallace Taylor, Rose Gana Fomban Leke
OBJECTIVE: Mycobacterium tuberculosis isolates that fail to hybridize to at least one rpoB wildtype or any mutation probe on the Genotype MTBDRplus strip are assumed Rifampicin-resistant. However, the precise mutation(s) are unknown. We sought to identify the mutations in isolates with such hybridization patterns and determine if the mutations are associated with resistance to Rifampicin. METHODS: In this study, 275 M. tuberculosis isolates were screened with the Genotype MTBDRplus assay to identify isolates with the hybridization pattern...
December 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29217094/treatment-of-infections-caused-by-nontuberculous-mycobacteria
#12
Jaime Esteban, Enrique Navas
Nontuberculous mycobacteria are a heterogeneous group of microorganisms that can often cause human infection, although they may also be considered to be contaminants or colonisers on occasions. The management of these infections must necessarily take into account the identification of isolated species and their in vitro susceptibility testing (although not for all of them), as well as the characteristics of the patient, because these treatments are usually prolonged and must be carried out by experts in the management of these infections...
December 4, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29216510/evolution-of-virulence-in-the-mycobacterium-tuberculosis-complex
#13
REVIEW
Mickael Orgeur, Roland Brosch
Mycobacterium tuberculosis, the causative agent of human tuberculosis is one of the most widely spread human pathogens. It has succeeded to infect a quarter of the global human population by developing most sophisticated ways to circumvent innate and adaptive immune defences. This highly specialized, major human pathogen has evolved from a pool of ancestral environmental mycobacteria, whose extant representatives are known under the name of Mycobacterium canettii. Recent whole genome analyses in combination with different phenotypic screens have provided key insights into the evolution of M...
December 4, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29216262/direct-detection-of-mycobacterium-tuberculosis-rifampin-resistance-in-bio-safe-stained-sputum-smears
#14
Surabhi Lavania, Divya Anthwal, Manpreet Bhalla, Nagendra Singh, Sagarika Haldar, Jaya Sivaswami Tyagi
Direct smear microscopy of sputum forms the mainstay of TB diagnosis in resource-limited settings. Stained sputum smear slides can serve as a ready-made resource to transport sputum for molecular drug susceptibility testing. However, bio-safety is a major concern during transport of sputum/stained slides and for laboratory workers engaged in processing Mycobacterium tuberculosis infected sputum specimens. In this study, a bio-safe USP (Universal Sample Processing) concentration-based sputum processing method (Bio-safe method) was assessed on 87 M...
2017: PloS One
https://www.readbyqxmd.com/read/29216039/corrigendum-persisting-positron-emission-tomography-lesion-activity-and-mycobacterium-tuberculosis-mrna-after-tuberculosis-cure
#15
Stephanus T Malherbe, Shubhada Shenai, Katharina Ronacher, Andre G Loxton, Gregory Dolganov, Magdalena Kriel, Tran Van, Ray Y Chen, James Warwick, Laura E Via, Taeksun Song, Myungsun Lee, Gary Schoolnik, Gerard Tromp, David Alland, Clifton E Barry, Jill Winter, Gerhard Walzl
This corrects the article DOI: 10.1038/nm.4177.
December 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29215013/allosteric-pyruvate-kinase-based-logic-gate-synergistically-senses-energy-and-sugar-levels-in-mycobacterium-tuberculosis
#16
Wenhe Zhong, Liang Cui, Boon Chong Goh, Qixu Cai, Peiying Ho, Yok Hian Chionh, Meng Yuan, Abbas El Sahili, Linda A Fothergill-Gilmore, Malcolm D Walkinshaw, Julien Lescar, Peter C Dedon
Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report biochemical, structural and metabolomic evidence that Mycobacterium tuberculosis (Mtb) PYK uses AMP and glucose-6-phosphate (G6P) as synergistic allosteric activators that function as a molecular "OR logic gate" to tightly regulate energy and glucose metabolism...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29214755/comparative-evaluation-of-the-loop-mediated-isothermal-amplification-assay-for-detecting-pulmonary-tuberculosis
#17
Chang Ki Kim, Eun A Cho, Dong Mi Shin, Sung Won Choi, So Youn Shin
BACKGROUND: Early detection of tuberculosis (TB) is challenging in resource-poor settings because of limited accessibility to molecular diagnostics. The aim of this study was to evaluate the performance of the loop-mediated isothermal amplification kit (TB-LAMP) for TB diagnosis compared with conventional and molecular tests. METHODS: A total of 290 consecutive sputum samples were collected from May till September, 2015. All samples were processed using the N-Acetyl-L-cysteine (NALC) NaOH method and tested by smear microscopy, solid and liquid culture, real-time PCR, and TB-LAMP...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29213997/cloning-optimization-of-induction-conditions-and-purification-of-mycobacterium-tuberculosis-rv1733c-protein-expressed-in-escherichia-coli
#18
Mitra Ashayeri-Panah, Fereshteh Eftekhar, Bahram Kazemi, Joan Joseph
Background and Objectives: Rv1733c is a latency antigen from Mycobacterium tuberculosis, a probable integral-membrane protein with promiscuous T-cell and B-cell epitopes, making it a potential vaccine candidate against tuberculosis. This study aimed to clone and optimize the expression of recombinant Rv1733c in Escherichia coli for purification. Materials and Methods: Chemically synthesized rv1733c coding sequence was cloned in pET-23a(+) followed by transforming E...
April 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29212913/molecular-characterisation-of-mycobacterium-caprae-strains-isolated-in-poland
#19
Monika Krajewska-Wędzina, Monika Kozińska, Blanka Orłowska, Marcin Weiner, Krzysztof Szulowski, Ewa Augustynowicz-Kopeć, Krzysztof Anusz, Noel H Smith
Bovine tuberculosis (bovine TB, bTB) is caused by bovine bacilli: Mycobacterium bovis and M caprae The studies conducted in Poland, in the National Bovine Tuberculosis Reference Laboratory in the Department of Microbiology of the National Veterinary Research Institute in Pulawy, show that animal tuberculosis in Poland is also caused by M caprae We here describe the identification and genotypic assessment of 52 isolates of M caprae obtained from Polish cattle and wild animals over the last five years. We show that strains isolated from bison have significant genotypic diversity and are distinct compared with the genotypes of strains isolated from cattle...
December 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29212699/rapid-microarray-based-detection-of-rifampicin-isoniazid-and-fluoroquinolone-resistance-in-mycobacterium-tuberculosis-using-a-single-cartridge
#20
Juliane Havlicek, Beatrice Dachsel, Peter Slickers, Sönke Andres, Patrick Beckert, Silke Feuerriegel, Stefan Niemann, Matthias Merker, Ines Labugger
Rapid and robust identification of mutations in Mycobacterium tuberculosis complex (MTBC) strains mediating multidrug and extensively drug-resistant (M/XDR) phenotypes is crucial to combat the MDR tuberculosis (TB) epidemic. Currently available molecular TB drug susceptibility tests are either restricted to single targets/drugs (i.e. Xpert MTB/RIF) or aid the risk of cross-contaminations due to the design limitations of the open platform (i.e. line probe assays).With a good understanding of the technical and commercial boundaries we designed a test cartridge with an introduction of dried reagents, based on an oligonucleotide array, which has the ability to identify MTBC strains resistant to isoniazid, rifampicin and the fluoroquinolones...
December 6, 2017: Journal of Clinical Microbiology
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