Danny A Milner, Jonathan J Lee, Charles Frantzreb, Richard O Whitten, Steve Kamiza, Richard A Carr, Alana Pradham, Rachel E Factor, Krupa Playforth, George Liomba, Charles Dzamalala, Karl B Seydel, Malcolm E Molyneux, Terrie E Taylor
Children in sub-Saharan Africa continue to acquire and die from cerebral malaria, despite efforts to control or eliminate the causative agent, Plasmodium falciparum. We present a quantitative histopathological assessment of the sequestration of parasitized erythrocytes in multiple organs obtained during a prospective series of 103 autopsies performed between 1996 and 2010 in Blantyre, Malawi, on pediatric patients who died from cerebral malaria and controls. After the brain, sequestration of parasites was most intense in the gastrointestinal tract, both in patients with cerebral malaria and those with parasitemia in other organs...
October 15, 2015: Journal of Infectious Diseases