Ragini Phansalkar, Vanessa S Goodwill, Jeffrey J Nirschl, Chiara De Lillo, Jihee Choi, Elizabeth Spurlock, David G Coughlin, Donald Pizzo, Christina J Sigurdson, Annie Hiniker, Victor E Alvarez, Ann C Mckee, Jonathan H Lin
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neuronal accumulation of hyper-phosphorylated tau (p-tau) and phospho-TDP43 (p-TDP43). Visual anomalies have been reported by patients with CTE, but the ocular pathology underlying these symptoms is unknown. We evaluated retinal pathology in post-mortem eyes collected from 8 contact sport athletes with brain autopsy-confirmed stage IV CTE and compared their findings to retinas from 8 control patients without CTE and with no known history of head injury...
September 22, 2023: Acta Neuropathologica Communications