keyword
https://read.qxmd.com/read/38533783/brain-morphometry-in-former-american-football-players-findings-from-the-diagnose-cte-research-project
#1
JOURNAL ARTICLE
Hector Arciniega, Zachary H Baucom, Fatima Tuz-Zahra, Yorghos Tripodis, Omar John, Holly Carrington, Nicholas Kim, Evdokiya E Knyazhanskaya, Leonard B Jung, Katherine Breedlove, Tim L T Wiegand, Daniel H Daneshvar, R Jarrett Rushmore, Tashrif Billah, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura J Balcer, Michael L Alosco, Inga K Koerte, Alexander P Lin, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Sylvain Bouix
Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI). MRI brain morphometry was evaluated in 170 male former American football players ages 45-74 years (n = 114 professional; n = 56 college) and 54 same-age unexposed asymptomatic male controls (n = 58 age range 45-74)...
March 27, 2024: Brain
https://read.qxmd.com/read/38493062/temperature-management-in-acute-brain-injury-a-narrative-review
#2
REVIEW
Eva Esther Tejerina Álvarez, José Ángel Lorente Balanza
Temperature management has been used in patients with acute brain injury resulting from different conditions, such as post-cardiac arrest hypoxic-ischaemic insult, acute ischaemic stroke, and severe traumatic brain injury. However, current evidence offers inconsistent and often contradictory results regarding the clinical benefit of this therapeutic strategy on mortality and functional outcomes. Current guidelines have focused mainly on active prevention and treatment of fever, while therapeutic hypothermia (TH) has fallen into disuse, although doubts persist as to its effectiveness according to the method of application and appropriate patient selection...
March 15, 2024: Medicina intensiva
https://read.qxmd.com/read/38458074/in-vitro-evaluation-of-3-h-pi-2620-and-structural-derivatives-in-non-alzheimer-s-tauopathies
#3
JOURNAL ARTICLE
Cassis Varlow, Chester A Mathis, Neil Vasdev
Alzheimer's disease (AD) and non-AD tauopathies such as chronic traumatic encephalopathy (CTE), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are characterized by the abnormal aggregation of three-repeat (3R) and/or four-repeat (4R) tau isoforms. Several tau-PET tracers have been applied for human imaging of AD and non-AD tauopathies including [18 F]PI-2620. Our objective is to evaluate [3 H]PI-2620 and two promising structural derivatives, [3 H]PI-2014 and [3 H]F-4, using in vitro saturation assays and competitive binding assays against new chemical entities based on this scaffold in human AD tissues for comparison with PSP, CBD and CTE tissues...
2024: Nuclear Medicine and Biology
https://read.qxmd.com/read/38452881/screening-for-delirium-during-pediatric-brain-injury-rehabilitation
#4
JOURNAL ARTICLE
William D Watson, Hsuan-Wei Chen, Ana K Ortiz, Adrian M Svingos, Stacy J Suskauer, Sudhin A Shah, Chani Traube
OBJECTIVE: To assess feasibility of routine delirium screening using the Cornell Assessment of Pediatric Delirium (CAPD) in children admitted for rehabilitation with acquired brain injury (ABI), report on the prevalence of positive delirium screens in this population, and explore longitudinal trends in CAPD scores and their association with rehabilitation outcomes. DESIGN: Retrospective study. SETTING: Pediatric inpatient rehabilitation unit...
March 5, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38348540/dnali1-promotes-neurodegeneration-after-traumatic-brain-injury-via-inhibition-of-autophagosome-lysosome-fusion
#5
JOURNAL ARTICLE
Xulong Ding, Shuqiang Cao, Qing Wang, Bin Du, Kefeng Lu, Shiqian Qi, Ying Cheng, Qing-Zhang Tuo, Weibo Liang, Peng Lei
Traumatic brain injury (TBI) leads to progressive neurodegeneration that may be caused by chronic traumatic encephalopathy (CTE). However, the precise mechanism remains unclear. Herein, the study identifies a crucial protein, axonemal dynein light intermediate polypeptide 1 (DNALI1), and elucidated its potential pathogenic role in post-TBI neurodegeneration. The DNALI1 gene is systematically screened through analyses of Aging, Dementia, and TBI studies, confirming its elevated expression both in vitro and in vivo...
February 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38157121/the-role-of-pkm2-in-multiple-signaling-pathways-related-to-neurological-diseases
#6
REVIEW
Xiaoping Zhang, Yihui Lei, Hongyan Zhou, Haijun Liu, Ping Xu
Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis. It is well known that PKM2 plays a vital role in the proliferation of tumor cells. However, PKM2 can also exert its biological functions by mediating multiple signaling pathways in neurological diseases, such as Alzheimer's disease (AD), cognitive dysfunction, ischemic stroke, post-stroke depression, cerebral small-vessel disease, hypoxic-ischemic encephalopathy, traumatic brain injury, spinal cord injury, Parkinson's disease (PD), epilepsy, neuropathic pain, and autoimmune diseases...
December 29, 2023: Molecular Neurobiology
https://read.qxmd.com/read/38147704/mri-volumetry-and-diffusion-tensor-imaging-for-diagnosis-and-follow-up-of-late-post-traumatic-injuries
#7
JOURNAL ARTICLE
Alice Jacquens, Pierre-Romain Delmotte, Claire Gourbeix, Nicolas Farny, Bérenger Perret-Liaudet, Dany Hijazi, Valentine Batisti, Grégory Torkomian, Didier Cassereau, Clara Debarle, Eimad Shotar, Celia Gellman, Bertrand Mathon, Eleonor Bayen, Damien Galanaud, Vincent Perlbarg, Louis Puybasset, Vincent Degos
BACKGROUND: Traumatic Brain Injury (TBI) is a major cause of acquired disability and can cause devastating and progressive post-traumatic encephalopathy. TBI is a dynamic condition that continues to evolve over time. A better understanding of the pathophysiology of these late lesions is important for the development of new therapeutic strategies. OBJECTIVES: The primary objective was to compare the ability of fluid-attenuated reversion recovery (FLAIR) and diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) markers to identify participants with a Glasgow outcome scale extended (GOS-E) score of 7-8, up to 10 years after their original TBI...
December 25, 2023: Annals of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38112365/polymorphism-of-ace-and-at2r1-genes-as-a-genetic-background-for-different-types-of-encephalopathies
#8
JOURNAL ARTICLE
Khrystyna Duve, Shkrobot Svitlana, Olena Tkachenko
OBJECTIVE: The aim: To study the prevalence of ACE I/D and AT2R1 A1166C gene polymorphisms in patients with CTE, SVD, AIE, and PIE and to assess the influence of the presence of a particular genotype of the studied genes on the occurrence and/or progression of encephalopathies. PATIENTS AND METHODS: Materials and methods: A total of 96 patients with encephalopathies of various genesis (chronic traumatic encephalopathy (CTE) n=26; chronic alcohol-induced encephalopathy (AIE) n=26; microvascular ischemic disease of the brain (or cerebral small vessel disease, (SVD)) n=18; post-infectious encephalopathy (PIE) n=26) were involved in the study...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38069849/the-neurological-manifestations-and-functional-independence-in-patients-with-encephalopathies-of-different-types
#9
JOURNAL ARTICLE
Khrystyna V Duve, Svitlana I Shkrobot
OBJECTIVE: Aim: To access the neurological manifestations and activities of daily living in patients with encephalopathy of one of the following types: post-infectious, chronic traumatic encephalopathy, alcohol-induced, and microvascular ischemic disease of the brain. PATIENTS AND METHODS: Materials and Methods: In the period of 2021-2022 we examined 520 patients, who signed the informed consent, taking into account their age, sex, occupation, the cause, and the disease duration...
2023: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38026695/upregulation-of-lrrk2-following-traumatic-brain-injury-does-not-directly-phosphorylate-thr-175-tau
#10
JOURNAL ARTICLE
Neil Donison, Matthew Hintermayer, Maegha Subramaniam, Erin Santandrea, Kathryn Volkening, Michael J Strong
Phosphorylated microtubule-associated protein tau (tau) aggregates are a pathological hallmark of various neurodegenerative diseases, including chronic traumatic encephalopathy and amyotrophic lateral sclerosis with cognitive impairment. While there are many residues phosphorylated on tau, phosphorylation of threonine 175 (pThr175 tau) has been shown to initiate fibril formation in vitro and is present in pathological tau aggregates in vivo . Given this, preventing Thr175 tau phosphorylation presents a potential approach to reduce fibril formation; however, the kinase(s) acting on Thr175 are not yet fully defined...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/37994884/-recognan-citicoline-efficacy-and-safety-in-cognitive-impairment-correction-of-various-nosological-forms
#11
JOURNAL ARTICLE
O A Shavlovskaya, I A Bokova
Insufficiency of a choline derivative (acetylcholine) can lead to the development of cognitive impairment (CI). One of the most well-known and well-studied medical drugs (MD) containing choline and having neuroprotective properties is citicoline (Recognan). A number of studies have demonstrated the effectiveness of Recognan in relation to mild CI, chronic cerebrovascular diseases (CVD), acute vascular disorders (including post-traumatic genesis). Recognan improves memory and other cognitive functions in healthy young people against the background of asthenia due to stress or increased cognitive and emotional stress or infection, and also has a preventive effect on fading cognitive functions in the process of age-related changes...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37942971/-the-possibilities-of-mexidol-usage-in-neuropediatrics
#12
JOURNAL ARTICLE
N N Zavadenko, N Yu Suvorinova, A N Zavadenko
Mexidol (ethylmethylhydroxypyridine succinate) is a modern neurometabolic medication increasingly being used in neuropediatrics. The results of recent studies confirming the positive effects of Mexidol pharmacotherapy in children with attention deficit hyperactivity disorder (ADHD), perinatal damages of the central nervous system (hypoxic-ischemic encephalopathy) and their consequences, neurological disorders and neurodevelopmental delay after surgery for congenital heart defects, neuroinfections (meningitis, encephalitis), posttraumatic epilepsy...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37899268/effective-epilepsy-surgery-for-post-traumatic-west-syndrome-following-abusive-head-trauma
#13
Hiroki Tsuchiya, Takashi Shibata, Tatsuya Sasaki, Takushi Inoue, Isao Date, Tomoyuki Akiyama, Katsuhiro Kobayashi
West syndrome, an infantile developmental and epileptic encephalopathy with a deleterious impact on long-term development, requires early treatment to minimize developmental abnormality; in such cases, epilepsy surgery should be considered a powerful therapeutic option. We describe a 10-month-old female admitted with West syndrome associated with a hemispheric lesion following abusive head trauma. Her seizures were suppressed by hemispherotomy at 12 months of age, leading to developmental improvement. Surgical treatment of West syndrome following traumatic brain injury has not been reported previously but is worth considering as a treatment option, depending on patient age and brain plasticity...
October 2023: Acta Medica Okayama
https://read.qxmd.com/read/37875713/increased-expression-of-k-na-1-2-channel-by-mapk-pathway-regulates-neuronal-activity-following-traumatic-brain-injury
#14
JOURNAL ARTICLE
Ru Liu, Lei Sun, Xiaorui Shi, Ci Li, Xi Guo, Yingting Wang, Xiu Wang, Kai Zhang, Yongjun Wang, Qun Wang, Jianping Wu
Recent studies have indicated that functional abnormalities in the KNa 1.2 channel are linked to epileptic encephalopathies. However, the role of KNa 1.2 channel in traumatic brain injury (TBI) remains limited. We collected brain tissue from the TBI mice and patients with post-traumatic epilepsy (PTE) to determine changes in KNa 1.2 channel following TBI. We also investigated whether the MAPK pathway, which was activated by the released cytokines after injury, regulated KNa 1.2 channel in in vitro. Finally, to elucidate the physiological significance of KNa 1...
October 25, 2023: Neurochemical Research
https://read.qxmd.com/read/37846159/chronic-traumatic-encephalopathy-neuropathologic-change-in-a-routine-neuropathology-service-7-year-follow-up
#15
JOURNAL ARTICLE
Marc R Del Bigio, Sherry Krawitz, Namita Sinha
To follow our 2016 study of chronic traumatic encephalopathy neuropathologic change (CTE-NC) in our forensic autopsy service, we prospectively screened all cases with clinical histories of multiple concussions, persistent post-head injury symptoms, or ≥3 hospital investigations for head injuries from 2016 to 2022 inclusive using hyperphosphorylated tau (p-tau) immunostaining. The cases had routine brain sampling plus 4-6 additional lateral hemisphere samples. When "pathognomonic" CTE-NC lesions were identified, additional p-tau immunostaining was done for CTE-NC staging...
October 16, 2023: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/37840527/polypathology-associated-neurodegeneration-after-remote-head-injury
#16
JOURNAL ARTICLE
Declan Brennan, Conor Delaney, Michael Farrell, Matthew Campbell, Colin P Doherty
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. TBI ranges from mild to severe and is a recognized risk factor for later neurodegenerative conditions including chronic traumatic encephalopathy (CTE), Alzheimer disease (AD) and Parkinson disease (PD). The development of CTE is typically associated with repetitive exposure to mild TBI (mTBI), while a single moderate-to-severe TBI is considered a risk factor for AD and PD. Polypathology is common, and the lines between these conditions post TBI can be somewhat blurred...
2023: Clinical Neuropathology
https://read.qxmd.com/read/37833041/alzheimer-s-disease-marker-phospho-tau181-is-not-elevated-in-the-first-year-after-moderate-to-severe-tbi
#17
JOURNAL ARTICLE
Neil Graham, Karl Zimmerman, Amanda J Heslegrave, Ashvini Keshavan, Federico Moro, Samia Abed-Maillard, Adriano Bernini, Vincent Dunet, Elena Garbero, Giovanni Nattino, Arturo Chieregato, Enrico Fainardi, Camelia Baciu, Primoz Gradisek, Sandra Magnoni, Mauro Oddo, Guido Bertolini, Jonathan M Schott, Henrik Zetterberg, David Sharp
BACKGROUND: Traumatic brain injury (TBI) is associated with the tauopathies Alzheimer's disease and chronic traumatic encephalopathy. Advanced immunoassays show significant elevations in plasma total tau (t-tau) early post-TBI, but concentrations subsequently normalise rapidly. Tau phosphorylated at serine-181 (p-tau181) is a well-validated Alzheimer's disease marker that could potentially seed progressive neurodegeneration. We tested whether post-traumatic p-tau181 concentrations are elevated and relate to progressive brain atrophy...
October 13, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37807166/a-33-clock-drawing-performance-differences-in-world-trade-center-responders-at-midlife
#18
JOURNAL ARTICLE
Stephanie Santiago-Michels, Sean Clouston, Laura A Rabin, Minos Kritikos, Alison Pellecchia, Veronica Scott, Melissa Carr, Benjamin Luft
OBJECTIVE: World Trade Center (WTC) responders demonstrate elevated risk for cognitive impairment (CI) consistent with Alzheimer's Disease and Related Dementias (ADRD). Neuropsychological test performance is valuable in early detection efforts and non-invasive longitudinal tracking of populations at risk of ADRD. We hypothesized that WTC-CI would be associated with a greater number of errors on the clock drawing task (CDT). METHOD: The CDT was administered to responders with/without CI who participated in a case/control study...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37803326/determinants-of-astrocytic-pathology-in-stem-cell-models-of-primary-tauopathies
#19
JOURNAL ARTICLE
Kimberly L Fiock, Jordan N Hook, Marco M Hefti
Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE). In all of these diseases, astrocytic tau consists mostly of the longer (4R) tau isoform, even when adjacent neuronal aggregates consist of a mixture of 3- and 4R tau, as in CTE. Even the rare astrocytic tau aggregates seen in Pick's disease appear to contain both 3R and 4R tau. The reasons for this, and the mechanisms by which astrocytic tau aggregates form, remain unclear...
October 6, 2023: Acta Neuropathologica Communications
https://read.qxmd.com/read/37772307/late-presentation-of-chronic-traumatic-encephalopathy-in-a-former-association-football-player
#20
JOURNAL ARTICLE
Patrick W Cullinane, Sarah Wrigley, Teisha Y Bradshaw, Karen Shaw, Samuel Shribman, Eduardo de Pablo Fernandez, Thomas T Warner, Zane Jaunmuktane
BACKGROUND: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by widespread accumulation of hyperphosphorylated tau that typically occurs in people who have suffered repetitive head impacts. To date, very few cases have been reported in association football players. OBJECTIVES: To describe the clinicopathological features of a case of CTE in an 84-year-old former football player who was clinically diagnosed as having dementia with Lewy bodies (DLB)...
September 2023: Movement Disorders Clinical Practice
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