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Aging ailments

Trine Eilenberg
Health anxiety is prevalent (5-9%) in all healthcare settings and in the general population, may have an early onset, and a poor prognosis is seen in severe cases if untreated. Research shows that health anxiety is rarely diagnosed though it causes great suffering for the individual and constitutes a substantial socio-economic burden. Studies have shown that individual cognitive behavioural therapy can relieve health anxiety, but these studies are affected by methodological problems, among others, struggling with patients declining participation, high dropout rates, and some patients not responding to the treatment...
October 2016: Danish Medical Journal
Mehwesh Taj, Tayyaba Shah, Syeda Kanwal Aslam, Sidra Zaheer, Faryal Nawab, Sumaira Shaheen, Kashif Shafique, Tahir Sultan Shamsi
AIM: Aplastic anemia (AA) affects the Asian population two to three fold more than people in other regions. Besides the host genetics and socioeconomic status, several other environmental exposures have been linked with an AA etiology. We aimed to examine the association of various environmental exposures with AA occurrence among Pakistani individuals. SUBJECTS AND METHODS: A case-control study was conducted in Karachi, Pakistan, where cases (diagnosed AA patients) were selected from the National Institute of Blood Disease and Bone Marrow Transplantation (NIBD), while for each case, a single control (who was free of AA and visited the outpatient department of the same hospital for the treatment of minor ailments) was selected matched by age and sex...
2016: Zeitschrift Für Gesundheitswissenschaften, Journal of Public Health
I S Hettigama, H K G Punchihewa, N K Heenkenda
BACKGROUND: Foot ailments are common among schoolchildren, some of which may be attributed to wearing ill-fitting footwear. As schoolchildren often participate in athletic activity, they are doubly vulnerable to foot ailments, and are particularly vulnerable to conditions such as hallux valgus, Achilles tendonitis, athlete's foot, corns and calluses. Thus, there is an acute need for the design and manufacture of ergonomic footwear for this target group. While research on appropriate footwear for children has been carried out in relation to child populations in other societies, research on the circumstances of Sri Lankan schoolchildren is lacking...
October 17, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
Ashish Sharma, Rohit Goyal
Preclinical Research Circadian rhythms are fundamental processes in all cells that coordinate a variety of cellular functions related to a specific time of the day. Disruption of circadian rhythms markedly impacts homeostasis. In this Commentary, we present data that disruption of circadian rhythm may lead to the pathogenesis of neurodegenerative states. In this context, we further argue that there is an urgent need of developing new generations of compounds, chronobiotics, to modulate the molecular substrates of circadian timing system...
September 30, 2016: Drug Development Research
J D Raja, S K Bhasin
BACKGROUND: Call center sector in India is a relatively new and fast growing industry driving employment and growth in modern India today. Most international call centers in National Capital Region (NCR) of Delhi operate at odd work hours corresponding to a time suitable fortheir international customers. The sleep quality of call handlers employed in these call centers is in jeopardy owing to their altered sleep schedule. OBJECTIVE: To assess the sleep quality and determine its independent predictors among call handlers employed in international call centers in NCR of Delhi...
October 2016: International Journal of Occupational and Environmental Medicine
Himanshu Khurana, Yatin Mehta, Sunil Dubey
BACKGROUND AND AIMS: Long distance air travel for medical needs is on the increase worldwide. The condition of some patients necessitates specially modified aircraft, and monitoring and interventions during transport by trained medical personnel. This article presents our experience in domestic and international interhospital air medical transportation from January 2010 to January 2014. MATERIAL AND METHODS: Hospital records of all air medical transportation undertaken to the institute during the period were analyzed for demographics, primary etiology, and events during transport...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
Vijaykumar Nandvadekar, Sandeep V Binorkar
BACKGROUND: Ayurveda has classified humans according to Deha-Mānasa prakṛti. It has given equal emphasis to both physical and psychological status of the individual. Constitution or configuration is an individual's peculiar set up of body and mind. It is also of importance in etiopathogenesis, prognosis and treatment procedures of various ailments. It is said that nature has its relative roles in causing individual and group differences in their respective cognitive abilities. AIM: The present study was designed to validate and assess the Intelligence Quotient of individuals of different Prakṛtis...
April 2016: Ancient Science of Life
G C Ilechukwu, Cga Ilechukwu, B C Ezeanolue, I J Okoroafor, N C Ojinnaka, A C Ubesie, G O Emechebe, J Eze
BACKGROUND: Ear related diseases are commonly seen in clinics worldwide especially among children. They are associated with significant morbidity and frequent hospital visits. Limited data exists regarding the burden of ear disease among Nigerian children. OBJECTIVE: To determine the prevalence of ear-related problems among children presenting at the Paediatric and Otorhinolaryngology clinics of the University of Nigeria Teaching Hospital, Enugu. MATERIALS AND METHODS: This was a cross-sectional study conducted at the Paediatric and Otorhinolaryngology Clinics of the University of Nigeria Teaching Hospital Enugu...
June 2016: African Health Sciences
Matthew Ryan Macey, Mathew C Raynor
Benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS) is one of the most common ailments affecting aging men. Symptoms typically associated with BPH include weak stream, hesitancy, urgency, frequency, and nocturia. More serious complications of BPH include urinary retention, gross hematuria, bladder calculi, recurrent urinary tract infection, obstructive uropathy, and renal failure. Evaluation of BPH includes a detailed history, objective assessment of urinary symptoms with validated questionnaires, and measurement of bladder function parameters, including uroflowmetry and postvoid residual...
September 2016: Seminars in Interventional Radiology
Joanne Hui Min Quah, Pei Wang, Roderica Rui Ge Ng, Nan Luo, Ngiap Chuan Tan
AIM: Older adults are susceptible to two or more chronic ailments or multimorbidity. The present study aimed to establish the relationship between multimorbidity and health-related quality of life (HRQoL) amongst Asian elderly patients in primary care in a developed nation. It also assessed how functional disability and chronic musculoskeletal pain are associated with HRQoL. METHODS: A cross-sectional study was carried out in a Singapore public primary care clinic...
August 31, 2016: Geriatrics & Gerontology International
Ayesha Nathoo
In 1972, a British charity, Relaxation for Living, was established "to promote the teaching of physical relaxation, to combat stress, strain, anxiety and the tension of modern life, and to reduce fatigue". This article explores the origins and development of "physical relaxation" techniques and ideologies, starting in the interwar period, and the development of practical, therapeutic, social and cultural frameworks necessary for such an organization to come into being in 1970s Britain. It traces how relaxation was reconstituted as a scientifically-based skill that could be learnt and taught, imbued with therapeutic value for combating and preventing specific physical ailments and enhancing individual health and wellbeing...
July 19, 2016: Palgrave Commun
O Schneider, H-P Scharf, T Stein, S Knapstein, C Hermann, J Flechtenmacher
BACKGROUND: Musculoskeletal illnesses and injuries are among the most common ailments in the Federal Republic of Germany. In 2008 they generated costs of nearly 29 billion euros. Figures about their incidence and prevalence are necessary for a demand-oriented planning of future patient-centred care. METHOD: Pseudonymised data of 3.8 million people insured by AOK Baden-Württemberg between 2008 and 2013 were evaluated. The diagnoses were assigned to nine injury groups...
August 12, 2016: Der Orthopäde
K Venugopal Menon, Tamer Malak Moawad Sorour
BACKGROUND: The prevalence and characteristics of spontaneous spondylodiscitis in the Middle East is unknown. There seems to be an emerging dominance of pyogenic infections over Tuberculosis and Brucellosis. METHODS: Retrospective observational study based on electronic case records of 4 years from a tertiary reference facility in Oman. Case records, microbiology reports, blood reports, imaging studies, histopathology and surgical reports of all spinal infection cases were studied...
August 2, 2016: World Neurosurgery
C Ntsapi, B Loos
Caloric restriction (CR) is known to extend lifespan in most organisms, indicating that nutrient and energy regulatory mechanisms impact aging. The greatest risk factor for neurodegeneration is age; thus, the antiaging effects of CR might attenuate progressive cell death and avert the aggregation of abnormal proteins associated with neurodegenerative diseases. CR is a potent inducer of autophagy, a tightly regulated intracellular process that facilitates recycling of abnormal protein aggregates and damaged organelles into bioenergetic and biosynthetic materials to maintain homeostasis...
October 2016: Experimental Gerontology
Danielle N Rendina, Carol D Ryff, Christopher L Coe
Dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, peak in young adulthood and then decrease dramatically with age. However, there is extensive variation in this age-related hormone decline, suggesting an early decrement may be associated with lower vitality and be prognostic of poor health in old age. To determine whether DHEA-S and DHEA are correlated with physical indices of vitality, hormone levels were analyzed with respect to clinical health histories, physical functioning including grip strength, gait speed and repetitive standing, and self-reported chronic pain...
July 28, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
K Hemalatha, G Madhumitha
Poly(adenosine diphosphate-ribose) polymerase (PARP) is a group of enzymes with several subtypes and it manages various ailment such as cancer, inflammatory disorders, diabetes mellitus, neuronal injury, HIV infection, Parkinsonism, aging, and ischemia-reperfusion injury. Various PARP inhibitors share a common property of bicyclic lactam in its main structural frame. The core moiety containing bicyclic lactam rings are isoquinolinones, dihydroisoquinolinones, quinazolinediones, phthalazinones, quinazolinones, and phenanthridones...
September 2016: Applied Microbiology and Biotechnology
Tripti Mishra, Rakesh Kumar Arya, Sanjeev Meena, Pushpa Joshi, Mahesh Pal, Baleshwar Meena, D K Upreti, T S Rana, Dipak Datta
Betula utilis, also known as Himalayan silver birch has been used as a traditional medicine for many health ailments like inflammatation, HIV, renal and bladder disorders as well as many cancers from ages. Here, we performed bio-guided fractionation of Betula utilis Bark (BUB), in which it was extracted in methanol and fractionated with hexane, ethyl acetate, chloroform, n-butanol and water. All six fractions were evaluated for their in-vitro anticancer activity in nine different cancer cell lines and ethyl acetate fraction was found to be one of the most potent fractions in terms of inducing cytotoxic activity against various cancer cell lines...
2016: PloS One
Smita Awasthi, Reason Wilken, Forum Patel, J Bruce German, David A Mills, Carlito B Lebrilla, Kyoungmi Kim, Samara L Freeman, Jennifer T Smilowitz, April W Armstrong, Emanual Maverakis
BACKGROUND: The development of probiotics as therapies to cure or prevent disease lags far behind that of other investigational medications. Rigorously designed phase I clinical trials are nearly non-existent in the field of probiotic research, which is a contributing factor to this disparity. As a consequence, how to appropriately dose probiotics to study their efficacy is unknown. Herein we propose a novel phase I ascending dose trial of Bifidobacterium longum subsp. infantis (B. infantis) to identify the dose required to produce predominant gut colonisation in healthy breastfed infants at 6 weeks of age...
2016: Trials
Edward J Wladis, Roman Shinder, Daniel R LeFebvre, Jason A Sokol, Michelle Boyce
Dacryocystitis-related orbital cellulitis is a relatively rare condition, and large case series of this clinical entity have been reported. This study was undertaken to identify a larger cohort of patients with this ailment, with the intent of defining its clinical and microbiologic features. Case logs from four institutions were reviewed to identify patients that suffered from dacryocystitis-related orbital cellulitis. A retrospective chart review was then performed to identify clinical features, management strategies, microbiologic features, and outcomes...
October 2016: Orbit
Balasubramanian Kumara-Raja, Gubbihal Radha
BACKGROUND: Among the various oral ailments which have been observed in elderly, root caries is a significant one. Tooth loss is chief oral health-related negative variable to the quality of life in elderly and root caries is the major cause of tooth loss in them. It has been reported about a third of older population bears most of the root caries burden, so the present study aimed to assess the prevalence of root caries among older individuals residing in residential homes of Bengaluru city India...
July 2016: Journal of Clinical and Experimental Dentistry
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