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https://www.readbyqxmd.com/read/27915041/garlic-active-constituent-s-allyl-cysteine-protects-against-lipopolysaccharide-induced-cognitive-deficits-in-the-rat-possible-involved-mechanisms
#1
Mahboubeh Zarezadeh, Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Mehrdad Roghani
Neuroinflammation is known as a risk factor for cognitive deficit and dementia and its incidence increased with aging. S-allyl cysteine (SAC) is the active and main component of aged garlic extract with anti-inflammatory, neuroprotective, and nootropic potential. In this study, the protective effect of SAC against lipopolysaccharide (LPS)-induced cognitive deficit in the rat was investigated. For induction of learning and memory impairment and neuroinflammation, LPS was intraperitoneally injected at a dose of 167 μg/kg for 7 days and SAC was administered p...
November 30, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27914877/transcultural-adaptation-and-validation-of-the-chinese-version-of-the-intermittent-and-constant-osteoarthritis-pain-icoap-measure-in-patients-with-knee-osteoarthritis
#2
Chen Zhang, Denghui Liu, Yulan Qu, Zhenyu Jia, Wei Wang, Jia Li, Weidong Xu
OBJECTIVE: This study aimed to translate and adapt the intermittent and constant osteoarthritis pain (ICOAP) measure into the Chinese language (ICOAP-C), and to study its psychometric properties in patients with knee osteoarthritis (OA). DESIGN: The ICOAP was translated and cognitively pretested following internationally recommended guidelines. The psychometric properties including the reliability, validity and responsiveness were evaluated. The reliability, including the internal consistency and the test-retest reliability, was then evaluated in 108 outpatients with knee OA...
November 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27914870/co-occurrence-and-predictors-of-three-commonly-occurring-behavioral-symptoms-in-dementia-agitation-aggression-and-rejection-of-care
#3
Scott Seung W Choi, Chakra Budhathoki, Laura N Gitlin
OBJECTIVE: To investigate co-occurrences of agitation, aggression, and rejection of care in community-dwelling families living with dementia. METHODS: Cross-sectional, secondary analysis from a randomized controlled trial testing a nonpharmacological intervention to reduce behavioral symptoms. We examined frequency of occurrence of presenting behaviors at baseline and their combination. Omnibus tests compared those exhibiting combinations of behaviors on contributory factors...
November 3, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27914825/amelioration-of-ischemia-reperfusion-induced-functional-and-biochemical-deficit-in-mice-by-ocimum-kilimandscharicum-leaf-extract
#4
Varinder Singh, Pawan Krishan, Nirmal Singh, Amit Kumar, Richa Shri
The genus Ocimum (family Lamiaceae) has been revered for its diverse biological activities. Various species have been used traditionally to treat CNS disorders and are proven to have neuroprotective effect that is often attributed to their significant antioxidant activity. Ocimum kilimandscharicum (Karpoora Thulasi), a prominent member of this genus is reported to have marked antioxidant activity but its neuroprotective potential has not been explored. Thus, present study was designed to evaluate the cerebroprotective effect of O...
November 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27914473/effectiveness-of-enhanced-cognitive-behavioral-therapy-cbt-e-for-eating-disorders-study-protocol-for-a-randomized-controlled-trial
#5
Martie de Jong, Kees Korrelboom, Iris van der Meer, Mathijs Deen, Hans W Hoek, Philip Spinhoven
BACKGROUND: While eating disorder not otherwise specified (EDNOS) is the most common eating disorder (ED) diagnosis in routine clinical practice, no specific treatment methods for this diagnosis have yet been developed and studied. Enhanced cognitive behavioral therapy (CBT-E) has been described and put to the test as a transdiagnostic treatment protocol for all EDs, including EDNOS. Initial research in the UK suggests that CBT-E is more effective for EDs, especially bulimia nervosa (BN) and EDNOS, than the earlier version of CBT...
December 3, 2016: Trials
https://www.readbyqxmd.com/read/27914406/energetic-and-informational-masking-of-complex-sounds-by-a-bottlenose-dolphin-tursiops-truncatus
#6
Brian K Branstetter, Kimberly Bakhtiari, Amy Black, Jennifer S Trickey, James J Finneran, Hitomi Aihara
With few exceptions, laboratory studies of auditory masking in marine mammals have been limited to examining detection thresholds for simple tonal signals embedded in broadband noise. However, detection of a sound has little adaptive advantage without the knowledge of what produced the sound (recognition) and where the sound originated (localization). In the current study, a bottlenose dolphin's masked detection thresholds (energetic masking) and masked recognition thresholds (informational masking) were estimated for a variety of complex signals including dolphin vocalizations, frequency modulated signals, and a 10 kHz pure tone...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27913953/neuroinflammation-induced-downregulation-of-hippocampacal-neuregulin-1-erbb4-signaling-in-the-parvalbumin-interneurons-might-contribute-to-cognitive-impairment-in-a-mouse-model-of-sepsis-associated-encephalopathy
#7
Rong Gao, Mu-Huo Ji, Da-Peng Gao, Run-Hua Yang, Shao-Gang Zhang, Jian-Jun Yang, Jin-Chun Shen
Sepsis-associated encephalopathy (SAE) is a common complication associated with poor prognosis in septic patients, but the underlying mechanism remains unclear. We hypothesized that disturbed neuregulin 1 (NRG1)-ErbB4 signaling in the parvalbumin interneurons was involved in sepsis-induced cognitive impairment in a mouse model of SAE. The SAE model was induced by cecal ligation/perforation (CLP). Animals were randomly divided into the following six groups: sham + vehicle group, sham + NRG1 group, CLP + vehicle group, CLP + NRG1 group, CLP + NRG1 + AG1478 (ErbB4 inhibitor) group, and CLP + minocycline group...
December 2, 2016: Inflammation
https://www.readbyqxmd.com/read/27913557/translation-and-validation-of-the-cancer-related-fatigue-scale-in-greek-in-a-sample-of-patients-with-advanced-prostate-cancer
#8
Andreas Charalambous, Charis Kaite, Marianna Constantinou, Christiana Kouta
OBJECTIVE: To translate and validate the Cancer-Related Fatigue (CRF) Scale in the Greek language. DESIGN: A cross-sectional descriptive design was used in order to translate and validate the CRF Scale in Greek. Factor analyses were performed to understand the psychometric properties of the scale and to establish construct, criterion and convergent validity. SETTING: Outpatients' oncology clinics of two public hospitals in Cyprus. PARTICIPANTS: 148 patients with advanced prostate cancer undergoing chemotherapy...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27913387/using-multivariate-base-rates-to-interpret-low-scores-on-an-abbreviated-battery-of-the-delis-kaplan-executive-function-system
#9
Justin E Karr, Mauricio A Garcia-Barrera, James A Holdnack, Grant L Iverson
OBJECTIVE: Executive function consists of multiple cognitive processes that operate as an interactive system to produce volitional goal-oriented behavior, governed in large part by frontal microstructural and physiological networks. Identification of deficits in executive function in those with neurological or psychiatric conditions can be difficult because the normal variation in executive function test scores, in healthy adults when multiple tests are used, is largely unknown. This study addresses that gap in the literature by examining the prevalence of low scores on a brief battery of executive function tests...
December 1, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27913159/assessing-functional-performance-using-computer-based-simulations-of-everyday-activities
#10
Sara J Czaja, David A Loewenstein, Chin Chin Lee, Shih Hua Fu, Philip D Harvey
Current functional capacity (FC) measures for patients with schizophrenia typically involve informant assessments or are in paper and pencil format, requiring in-person administration by a skilled assessor. This approach presents logistic problems and limits the possibilities for remote assessment, an important issue for these patients. This study evaluated the feasibility of using a computer-based assessment battery, including simulations of everyday activities. The battery was compared to in-person standard assessments of cognition and FC with respect to baseline convergence and sensitivity to group differences...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27913085/anti-n-methyl-d-aspartate-receptor-encephalitis-and-rasmussen-like-syndrome-an-association
#11
Kevin Gurcharran, Shefali Karkare
BACKGROUND: N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune-mediated condition that has a broad spectrum of manifestations, including seizures, coma, psychosis, and focal neurological deficits. Although usually a diffuse process, unihemispheric involvement mimicking early stages of Rasmussen encephalitis can occur. Rasmussen's encephalitis is a unique syndrome characterized by progressive hemiplegia, drug-resistant focal epilepsy, cognitive decline, and hemispheric brain atrophy contralateral to the hemiplegia...
October 11, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27912947/exploratory-outcome-assessment-of-qigong-tai-chi-easy-on-breast-cancer-survivors
#12
Linda K Larkey, Denise J Roe, Lisa Smith, Denise Millstine
OBJECTIVE: Breast cancer survivors (BCSs) experience symptoms affecting overall quality of life (QOL), often for a prolonged period post-treatment. Meditative Movement (MM), including Qigong and Tai Chi Easy (QG/TCE), has demonstrated benefit for improving QOL issues such as fatigue and sleep, but there is limited evidence of its impact on cognitive function, overall physical activity, and body weight for BCSs. DESIGN: This double-blind, randomized controlled pilot study with 87 female BCSs explored effects of QG/TCE on mental and physical QOL (Medical Outcomes Survey, Short Form), cognitive function (Functional Assessment of Cancer Therapy-Cognitive Function and two cognitive performance tests from the WAIS III), overall levels of physical activity (PA)(Brief Physical Activity Questionnaire) and body mass index (BMI)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912928/translating-self-persuasion-into-an-adolescent-hpv-vaccine-promotion-intervention-for-parents-attending-safety-net-clinics
#13
Austin S Baldwin, Deanna C Denman, Margarita Sala, Emily G Marks, L Aubree Shay, Sobha Fuller, Donna Persaud, Simon Craddock Lee, Celette Sugg Skinner, Deborah J Wiebe, Jasmin A Tiro
OBJECTIVE: Self-persuasion is an effective behavior change strategy, but has not been translated for low-income, less educated, uninsured populations attending safety-net clinics or to promote human papillomavirus (HPV) vaccination. We developed a tablet-based application (in English and Spanish) to elicit parental self-persuasion for adolescent HPV vaccination and evaluated its feasibility in a safety-net population. METHODS: Parents (N=45) of age-eligible adolescents used the self-persuasion application...
November 20, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27912874/the-anxiolytic-effect-of-essential-oil-of-cananga-odorata-exposure-on-mice-and-determination-of-its-major-active-constituents
#14
Nan Zhang, Lei Zhang, Linyin Feng, Lei Yao
BACKGROUND: Essential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. HYPOTHESIS/PURPOSE: To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. STUDY DESIGN AND METHODS: ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27911937/an-investigation-of-the-outcomes-of-pgy-students-cognition-of-and-persistent-behavior-in-learning-through-the-intervention-of-the-flipped-classroom-in-taiwan
#15
Sheng-Der Hsu, Cheng-Jueng Chen, Wei-Kuo Chang, Yih-Jin Hu
The Postgraduate Year (PGY) Program allows doctors-in-training to learn about the diagnosis, treatment and nursing of various common, general diseases. These items form the core curriculum and are mostly learned through caring for patients and clinical teaching. Doctors-in-training are evaluated for their knowledge through written tests or assignments, based on which the effectiveness of their training is also assessed; however, this generally produces a negative learning attitude among them. So we introduced the flipped classroom into PGY training program to change PGY students' learning behavior...
2016: PloS One
https://www.readbyqxmd.com/read/27911914/performance-of-the-modified-mini-mental-state-examination-3ms-in-assessing-specific-cognitive-function-in-patients-undergoing-peritoneal-dialysis
#16
Yi Li, Xue Tian, Zu-Ying Xiong, Jin-Lan Liao, Li Hao, Gui-Ling Liu, Ye-Ping Ren, Qin Wang, Li-Ping Duan, Zhao-Xia Zheng, Wen-Xiang Quan, Jie Dong
PURPOSE: While Cognitive impairment (CI) has been identified as an independent risk factors for mortality in patients undergoing peritoneal dialysis (PD), it is inadequately assessed. We evaluated the applicability of the Modified Mini-Mental State Examination (3MS) in assessing specific cognitive function and compared it to a detailed neuropsychological test battery as the reference standard. METHODS: In this multicentric cross-sectional study, we enrolled 445 clinically stable patients from five PD units, who were undergoing PD for at least 3 months...
2016: PloS One
https://www.readbyqxmd.com/read/27911474/is-chelation-therapy-efficient-for-the-treatment-of-intravenous-metallic-mercury-intoxication
#17
Daniela Pelclova, Stepanka Vlckova, Ondrej Bezdicek, Manuela Vaneckova, Pavel Urban, Petr Ridzon, Pavel Diblik, Tomas Navratil, Pavlina Klusackova, Kamil Vlcek, Olga Benesova, Pavel Trestik, Jiri Homolka, Sergey Zakharov
The efficacy of treatment for intravenous elemental mercury intoxication has not been fully studied with regard to clinical outcomes, and treatment recommendations vary. We treated a 41-year-old man with a history of drug abuse and depression who attempted suicide using 1 mL (13.53 g) metallic Hg i.v. He was admitted to the hospital two months later for dyspnoea and thoracic pain and was diagnosed with pneumonia. Hg deposits were seen in the lungs and extra-pulmonary organs. His blood level (372 μg/L) exceeded the population level of 5 μg/L by more than 70-fold...
December 2, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27911319/autotaxin-is-related-to-metabolic-dysfunction-and-predicts-alzheimer-s-disease-outcomes
#18
Kelsey E McLimans, Auriel A Willette
BACKGROUND: Obesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease (AD). OBJECTIVE: Ecto-nucleotide pyrophosphatase/phosphodiesterase 2, also called autotaxin, is produced by beige adipose tissue, regulates metabolism, and is higher in AD prefrontal cortex (PFC). Autotaxin may be a novel biomarker of dysmetabolism and AD. METHODS: We studied Alzheimer's Disease Neuroimaging Initiative participants who were cognitively normal (CN; n = 86) or had mild cognitive impairment (MCI; n = 135) or AD (n = 66)...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911303/amylin-treatment-reduces-neuroinflammation-and-ameliorates-abnormal-patterns-of-gene-expression-in%C3%A2-the-cerebral-cortex-of-an-alzheimer-s-disease-mouse-model
#19
Erming Wang, Haihao Zhu, Xiaofan Wang, Adam Gower, Max Wallack, Jan Krzysztof Blusztajn, Neil Kowall, Wei Qiao Qiu
Our recent study has demonstrated that peripheral amylin treatment reduces the amyloid pathology in the brain of Alzheimer's disease (AD) mouse models, and improves their learning and memory. We hypothesized that the beneficial effects of amylin for AD was beyond reducing the amyloids in the brain, and have now directly tested the actions of amylin on other aspects of AD pathogenesis, especially neuroinflammation. A 10-week course of peripheral amylin treatment significantly reduced levels of cerebral inflammation markers, Cd68 and Iba1, in amyloid precursor protein (APP) transgenic mice...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911299/chronotropic-response-and-cognitive-function-in-a-cohort-at-risk-for%C3%A2-alzheimer-s-disease
#20
Lena L Law, Stephanie A Schultz, Elizabeth A Boots, Jean A Einerson, Ryan J Dougherty, Jennifer M Oh, Claudia E Korcarz, Dorothy F Edwards, Rebecca L Koscik, N Maritza Dowling, Catherine L Gallagher, Barbara B Bendlin, Cynthia M Carlsson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Sterling C Johnson, Dane B Cook, James H Stein, Ozioma C Okonkwo
The objective of this study was to examine the association of chronotropic response (CR) and heart rate (HR) recovery- two indices of cardiovascular function within the context of a graded exercise test- with cognitive performance in a cognitively healthy, late-middle-aged cohort at risk for Alzheimer's disease (AD). Ninety participants (age = 63.52±5.86 years; 65.6% female) from the Wisconsin Registry for Alzheimer's Prevention participated in this study. They underwent graded exercise testing and a comprehensive neuropsychological assessment that assessed the following four cognitive domains: Immediate Memory, Verbal & Learning Memory, Working Memory, and Speed & Flexibility...
December 1, 2016: Journal of Alzheimer's Disease: JAD
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