keyword
https://read.qxmd.com/read/38493366/cross-validation-of-the-response-bias-scale-and-the-response-bias-scale-19-in-active-duty-personnel-use-on-the-mmpi-2-rf-and-mmpi-3
#1
JOURNAL ARTICLE
Paul B Ingram, Patrick Armistead-Jehle, Lucas G Childers, Tristan T Herring
The Response Bias Scale (RBS) is the central measure of cognitive over-reporting in the MMPI-family of instruments. Relative to other clinical populations, the research evaluating the detection of over-reporting is more limited in Veteran and Active-Duty personnel, which has produced some psychometric variability across studies. Some have suggested that the original scale construction methods resulted in items which negatively impact classification accuracy and in response crafted an abbreviated version of the RBS (RBS-19; Ratcliffe et al...
March 17, 2024: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38493361/p300-parameters-in-major-depressive-disorder-a-systematic-review-and-meta-analysis
#2
REVIEW
Mehmet Kemal Arıkan, Reyhan İlhan, Özden Orhan, Muhammed Taha Esmeray, Şenol Turan, Şakir Gica, Hasan Bakay, Oliver Pogarell, Kâşif Nevzat Tarhan, Barış Metin
OBJECTIVES: Event-related potential measures have been extensively studied in mental disorders. Among them, P300 amplitude and latency reflect impaired cognitive abilities in major depressive disorder (MDD). The present systematic review and meta-analysis was conducted to investigate whether patients with MDD differ from healthy controls (HCs) with respect to P300 amplitude and latency. METHODS: PubMed and Web of Science databases were searched from inception to 15 January 2023 for case-control studies comparing P300 amplitude and latency in patients with MDD and HCs...
March 17, 2024: World Journal of Biological Psychiatry
https://read.qxmd.com/read/38493181/corneal-confocal-microscopy-may-help-to-distinguish-multiple-system-atrophy-from-parkinson-s-disease
#3
JOURNAL ARTICLE
Xuebin Niu, Peixiao Yin, Chenyang Guan, Qiuyue Shao, Guiyun Cui, Kun Zan, Chuanying Xu
Multiple system atrophy (MSA) and Parkinson's disease (PD) have clinical overlapping symptoms, which makes differential diagnosis difficult. Our research aimed to distinguish MSA from PD using corneal confocal microscopy (CCM), a noninvasive and objective test. The study included 63 PD patients, 30 MSA patients, and 31 healthy controls (HC). When recruiting PD and MSA, questionnaires were conducted on motor and non-motor functions, such as autonomic and cognitive functions. Participants underwent CCM to quantify the corneal nerve fibers...
March 16, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38492911/aquaporine-4-inhibition-attenuates-pentylentetrazole-induced-behavioral-seizures-and-cognitive-impairments-in-kindled-rats
#4
JOURNAL ARTICLE
Fatemeh Rostami, Ali Jaafari Suha, Mahyar Janahmadi, Narges Hosseinmardi
Epilepsy is a neurological condition distinguished by recurrent and unexpected seizures. Astrocytic channels and transporters are essential for maintaining normal neuronal functionality. The astrocytic water channel aquaporin-4 (AQP4), which plays a pivotal role in regulating water homeostasis, is a potential target for epileptogenesis. In present study, we examined the effect of different doses (10, 50, 100 μM and 5 mM) of AQP4 inhibitor, 2-nicotinamide-1, 3, 4-thiadiazole (TGN-020), during kindling acquisition, on seizure parameters and seizure-induced cognitive impairments...
March 14, 2024: Physiology & Behavior
https://read.qxmd.com/read/38492898/pterostilbene-nanoemulsion-promotes-nrf2-signaling-pathway-to-downregulate-oxidative-stress-for-treating-alzheimer-s-disease
#5
JOURNAL ARTICLE
Jingyu Liu, Jikai Xu, Luan Jia, Yanjun Zhou, Qiang Fu, Yichen Wang, Danyang Mu, Dequan Wang, Ning Li, Yue Hou
Pterostilbene, a stilbene compound, demonstrates neuroprotective effects through its antioxidant and anti-inflammatory properties. However, pterostilbene exhibits low bioavailability. We developed a pterostilbene nanoemulsion with better release stability and particle size. Behavioral tests, including the Y maze, new object recognition, and water maze, revealed that the pterostilbene nanoemulsion demonstrated a more significant effect on improving learning and memory function than pterostilbene. Immunofluorescence analysis revealed that pterostilbene nanoemulsion was more potent in safeguarding hippocampal neurons and inhibiting apoptosis and oxidative stress than pterostilbene...
March 14, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38492492/self-rated-health-in-old-age-related-factors-and-survival-a-20-year-longitudinal-study-within-the-silver-monica-cohort
#6
JOURNAL ARTICLE
Ariel Almevall, Albin Dahlin Almevall, Jerry Öhlin, Yngve Gustafson, Karin Zingmark, Johan Niklasson, Peter Nordström, Erik Rosendahl, Stefan Söderberg, Birgitta Olofsson
INTRODUCTION: Self-rated health (SRH) offers insights into the evolving health demographics of an ageing population. AIM: To assess change in SRH from old age to very old age and their associations with health and well-being factors, and to investigate the association between SRH and survival. METHODS: All participants in the MONICA 1999 re-examination born before 1940 (n = 1595) were included in the Silver-MONICA baseline cohort. The Silver-MONICA follow-up started in 2016 included participants in the Silver-MONICA baseline cohort aged 80 years or older...
February 29, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38492443/psychometric-properties-and-factor-structure-of-the-suicidal-narrative-inventory-in-major-depression-a-multicentric-evaluation
#7
JOURNAL ARTICLE
Vikas Menon, Ilambaridhi Balasubramanian, Megan L Rogers, Sandeep Grover, Bhavesh Lakdawala, Rajeev Ranjan, Sujit Sarkhel, Naresh Nebhinani, Roy Abraham Kallivayalil, Vijaya Raghavan, Kshirod Kumar Mishra, Jitender Aneja, Niteen Abhivant, Raman Deep, Lokesh Kumar Singh, Avinash De Sousa, Arvind Nongpiur, Alka A Subramanyam, Debadatta Mohapatra, Sujita Kumar Kar, Vishal Dhiman, Pn Suresh Kumar, Umesh Shreekantiah, Samrat Singh Bhandari, Ramdas Ransing, Vikhram Ramasubramanian, Samir Kumar Praharaj
BACKGROUND: The Suicidal Narrative Inventory (SNI) is a 38-item self-report measure developed to assess elements of the suicidal narrative, a subacute, predominantly cognitive, presuicidal construct. Our objectives were to assess the factor structure, validity, and reliability of the SNI-38 among adults with major depressive disorder (MDD). METHODS: Using a cross-sectional design, we administered the Hindi version of the SNI along with other self-report measures to adults with MDD, recruited from 24 tertiary care hospitals across India...
March 8, 2024: Asian Journal of Psychiatry
https://read.qxmd.com/read/38492436/significance-of-non-motor-symptoms-and-development-of-a-screening-tool-for-osteoporosis-in-parkinson-s-disease
#8
JOURNAL ARTICLE
Fang Zhang, Jianjun Lu, Yong Zhang, Jiawen Liu
BACKGROUND AND PURPOSE: Parkinson's disease (PD) patients have a higher likelihood of having osteoporosis compared to controls, therefore deserving special attention. This study was to 1) investigate the association of non-motor symptoms with osteoporosis amongst PD patients, and 2) develop screening tools for osteoporosis. MATERIALS AND METHODS: PD Patients were included (n = 109). The factors/variables were obtained from clinical records due to the retrospective nature of this study...
March 2, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38492366/lancao-decoction-alleviates-cognitive-dysfunction-a-new-therapeutic-drug-and-its-therapeutic-mechanism
#9
JOURNAL ARTICLE
Yan Sun, Hailou Zhang, Ruiyi Liu, Rumin Huang, Ziwei Gao, Liyuan Tian, Yaping Zhu, Yuxin Liu, Chao Lu, Lei Wu
BACKGROUND: Cognitive dysfunction (CD) is a neurodegenerative disease characterized primarily by the decline of learning and memory abilities. The physiological and pathological mechanisms of CD are very complex, which is mainly related to normal function of the hippocampus. Lancao decoction (LC) is a Chinese medicine formula, which has been used to treat neurodegenerative disorders. However, the potential of LC for the treatment of CD, as well as its underlying mechanisms, is unclear...
March 11, 2024: Phytomedicine
https://read.qxmd.com/read/38492271/resting-state-eeg-rhythms-are-abnormal-in-post-covid-19-patients-with-brain-fog-without-cognitive-and-affective-disorders
#10
JOURNAL ARTICLE
Claudio Babiloni, Elio Gentilini Cacciola, Federico Tucci, Paolo Vassalini, Agnese Chilovi, Dharmendra Jakhar, Andreea Maria Musat, Marco Salvatore, Andrea Soricelli, Fabrizio Stocchi, Laura Vacca, Raffaele Ferri, Valentina Catania, Claudio Mastroianni, Gabriella D'Ettorre, Giuseppe Noce
OBJECTIVES: Several persons experiencing post-covid-19 (post-COVID) with "brain fog" (e.g., fatigue, cognitive and psychiatric disorders, etc.) show abnormal resting-state electroencephalographic (rsEEG) rhythms reflecting a vigilance dysfunction. Here, we tested the hypothesis that in those post-COVID persons, abnormal rsEEG rhythms may occur even when cognitive and psychiatric disorders are absent. METHODS: The experiments were performed on post-COVID participants about one year after hospitalization for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
March 6, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38492241/propionic-acid-affects-the-synaptic-architecture-of-rat-hippocampus-and-prefrontal-cortex
#11
JOURNAL ARTICLE
Mzia G Zhvania, Giorgi Lobzhanidze, Nino Pochkhidze, Nadezhda Japaridze, Pavel Tchelidze, Fuad Rzayev, Eldar Gasimov
It is well documented that propionic acid (PPA) produces behavioral, morphological, molecular and immune responses in rats that are characteristic of autism spectrum disorder in humans. However, whether PPA affects the ultrastructure and synaptic architecture of regions of autistic brain has not been adequately addressed. Earlier we show that single intraperitoneal (IP) injection of PPA (175 mg/kg) produces superficial changes in the spatial memory and learning of adolescent male Wistar rats. However, in neurons, synapses and glial cells of hippocampal CA1 area and medial prefrontal cortex transient (mainly) or enduring alterations were detected...
March 4, 2024: Micron
https://read.qxmd.com/read/38492042/transcriptomic-contributions-to-a-modern-cytoarchitectonic-parcellation-of-the-human-cerebral-cortex
#12
JOURNAL ARTICLE
Leana King, Kevin S Weiner
Transcriptomic contributions to the anatomical, functional, and network layout of the human cerebral cortex (HCC) have become a major interest in cognitive and systems neuroscience. Here, we tested if transcriptomic differences support a modern, algorithmic cytoarchitectonic parcellation of HCC. Using a data-driven approach, we identified a sparse subset of genes that differentially contributed to the cytoarchitectonic parcellation of HCC. A combined metric of cortical thickness and myelination (CT/M ratio), as well as cell density, correlated with gene expression...
March 16, 2024: Brain Structure & Function
https://read.qxmd.com/read/38491852/metabolomics-based-effects-of-a-natural-product-on-remyelination-after-cerebral-ischemia-injury-via-gababr-pcreb-bdnf-pathway
#13
JOURNAL ARTICLE
Xiaodi Fan, Min Zhan, Wenting Song, Mingjiang Yao, Guangrui Wang, Tian Li, Yehao Zhang, Jianxun Liu
BACKGROUND: Yi-Qi-Tong-Luo Granules (YQTLs) is a natural compound of Traditional Chinese Medicine authorized by China Food and Drug Administration (CFDA). These granules are employed in the convalescent stage of cerebral infarction and render notable clinical efficacy. This study aims to uncover the underlying mechanisms of YQTLs on remyelination after cerebral ischemia injury. MATERIALS AND METHODS: We established cerebral ischemia model in rats using microsphere-induced multiple cerebral infarction (MCI)...
March 16, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38491750/editor-spotlight-interview-with-cholinergic-mechanisms-special-issue-guest-editor-hermona-soreq
#14
EDITORIAL
Kim H Kwan, Hermona Soreq
Hermona Soreq holds a Hebrew University Slesinger Chair in Molecular Neuroscience and is among the founding members of the Edmond and Lily Safra Center of Brain Sciences (ELSC). Soreq's research (H-impact: 98) focuses on acetylcholine (ACh)-related pathways and combines RNA-sequencing technologies, transgenic engineering, and molecular biology tests with in-depth analysis approaches. Her work addresses microRNAs (miRs) and transfer RNA fragments (tRFs) which have rapidly acquired wide recognition as global controllers of regulatory processes in healthy and diseased brain and body, including anxiety, inflammation, and cognition...
March 15, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38491546/heart-rate-and-breathing-effects-on-attention-and-memory-heartbeam-study-protocol-for-a-randomized-controlled-trial-in-older-adults
#15
JOURNAL ARTICLE
Kaoru Nashiro, Hyun Joo Yoo, Christine Cho, Andy Jeesu Kim, Padideh Nasseri, Jungwon Min, Martin J Dahl, Noah Mercer, Jeiran Choupan, Paul Choi, Hye Rynn J Lee, David Choi, Kalekirstos Alemu, Alexandra Ycaza Herrera, Nicole F Ng, Julian F Thayer, Mara Mather
BACKGROUND: In healthy people, the "fight-or-flight" sympathetic system is counterbalanced by the "rest-and-digest" parasympathetic system. As we grow older, the parasympathetic system declines as the sympathetic system becomes hyperactive. In our prior heart rate variability biofeedback and emotion regulation (HRV-ER) clinical trial, we found that increasing parasympathetic activity through daily practice of slow-paced breathing significantly decreased plasma amyloid-β (Aβ) in healthy younger and older adults...
March 15, 2024: Trials
https://read.qxmd.com/read/38491536/the-burden-of-traumatic-brain-injury-on-caregivers-exploring-the-predictive-factors-in-a-multi-centric-study
#16
JOURNAL ARTICLE
Mehran Ilaghi, Farhad Gharib, Ahmad Pirani, Abdol-Hossein Vahabie, Jordan Grafman, Seyed Vahid Shariat, Behnam Shariati, Amin Jahanbakhshi, Fatemeh Sadat Mirfazeli
BACKGROUND: Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide. With survivors often exhibiting degrees of function loss, a significant burden is exerted on their caregivers. The purpose of this study was to explore the predictive factors of caregiver burden among caregivers of patients with TBI. METHODS: Sixty-eight family members of individuals with a TBI who had been admitted to three hospitals were assessed in terms of caregiver burden using the Zarit Burden Interview...
March 15, 2024: BMC Psychology
https://read.qxmd.com/read/38491476/cultivating-compassion-in-medicine-a-toolkit-for-medical-students-to-improve-self-kindness-and-enhance-clinical-care
#17
JOURNAL ARTICLE
Krisha K Mehta, Shafkat Salam, Austin Hake, Rebecca Jennings, Afra Rahman, Stephen G Post
BACKGROUND: Compassionate care lies at the foundation of good patient care and is a quality that patients and providers continue to value in the fast-paced setting of contemporary medicine. Compassion is often discussed superficially in medical school curricula, but the practical aspect of learning this skill is often not taught using a formal framework. In the present work, the authors present an 8-session curriculum with a mindfulness-based approach to compassion that addresses this need...
March 15, 2024: BMC Medical Education
https://read.qxmd.com/read/38491473/relationship-between-physical-activity-and-risk-of-depression-in-a-married-group
#18
JOURNAL ARTICLE
Rong Jing Ni, Ying Yu
BACKGROUND: Currently, there are many different findings on the relationship between physical activity and depression, and there may be differences between genders. This study therefore focused on gender differences to understand the relationship between physical activity behaviour and the risk of depression in married individuals. METHODS: 15607 married people in the China Family Panel Studies 2020 (CFPS 2020) were used to understand the relationship between physical activity and depression risk in different populations, and the chi-square test, Mann-Whitney U-test, and binary logistic regression were used to explore the relationship between physical activity and depression risk in the married population...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38491466/causal-relationship-between-dietary-salt-intake-and-dementia-risk-mendelian-randomization-study
#19
JOURNAL ARTICLE
Ke Shi, Yongbo Yu, Zhaolin Li, Miaomiao Hou, Xinyi Li
OBJECTIVE: Observational research has indicated a potential link between dietary salt intake and susceptibility to dementia. However, it is important to note that these types of studies are prone to the issues of reverse causation and residual confounding. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causality. METHOD: To explore the causal relationship between them, this Mendelian randomization (MR) study incorporated summary statistics of dietary salt intake and dementia...
March 15, 2024: Genes & Nutrition
https://read.qxmd.com/read/38491393/long-term-high-fat-diet-consumption-aggravates-%C3%AE-amyloid-deposition-and-tau-pathology-accompanied-by-microglial-activation-in-an-alzheimer-s-disease-model
#20
JOURNAL ARTICLE
Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Bao
Alzheimer's disease (AD) is the most prevailing form of dementia, with long-term high-fat diet (HFD) consumption being a pivotal contributor to AD pathogenesis. As microglial dysfunction is a crucial factor in the AD onset, it becomes imperative to explore the effects of HFD on microglial function and AD pathogenesis. In the present study, 3xTg-AD model mice at the age of 9-month are subjected to random allocation, with one group receiving a standard diet (ND) and the other an HFD for 3 months. Subsequently, transcriptomic profiling of microglia unveils that HFD alters fatty acid metabolism and mediates T cell infiltration...
March 15, 2024: Molecular Nutrition & Food Research
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