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https://www.readbyqxmd.com/read/29236338/inflammatory-cytokine-and-c-reactive-protein-concentrations-in-dogs-with-systemic-inflammatory-response-syndrome
#1
Kris Gommeren, Isabelle Desmas, Alexandra Garcia, Natalie Bauer, Andreas Moritz, Joachim Roth, Dominique Peeters
OBJECTIVE: To evaluate C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) kinetics in dogs with a systemic inflammatory response syndrome (SIRS) presented to an emergency service. We hypothesized serum CRP concentrations would increase and vary during hospitalization, and would correlate with plasma IL-6 and TNF-α concentrations, vary in magnitude according to the underlying disease, and predict survival. DESIGN: Prospective, observational, clinical study...
December 13, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29236227/loss-of-vascular-expression-of-nucleoside-triphosphate-diphosphohydrolase-1-cd39-in-hypertension
#2
Charlotte Roy, Julie Tabiasco, Antoine Caillon, Yves Delneste, Jean Merot, Julie Favre, Anne Laure Guihot, Ludovic Martin, Daniele C Nascimento, Bernhard Ryffel, Simon C Robson, Jean Sévigny, Daniel Henrion, Gilles Kauffenstein
Ectonucleoside triphosphate diphosphohydrolase-1, the major vascular/immune ectonucleotidase, exerts anti-thrombotic and immunomodulatory actions by hydrolyzing extracellular nucleotides (danger signals). Hypertension is characterized by vascular wall remodeling, endothelial dysfunction, and immune infiltration. Here our aim was to investigate the impact of arterial hypertension on CD39 expression and activity in mice. Arterial expression of CD39 was determined by reverse transcription quantitative real-time PCR in experimental models of hypertension, including angiotensin II (AngII)-treated mice (1 mg/kg/day, 21 days), deoxycorticosterone acetate-salt mice (1% salt and uninephrectomy, 21 days), and spontaneously hypertensive rats...
December 13, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/29235392/re-evaluating-osteoporosis-and-fracture-risk-in-crohn-s-disease-patients-in-the-era-of-tnf-alpha-inhibitors
#3
Shahrad Hakimian, Joan Kheder, Seth Arum, David R Cave, Benjamin Hyatt
INTRODUCTION: Patients with Crohn's disease (CD) are at increased risk for osteoporosis and fractures as compared to the general population. Recently, various cytokines including tumor necrosis factor (TNF)-alpha are found to play a major role in bone health. In this study, we aimed to gain a better understanding of the risk factors for osteoporosis and vitamin D deficiency in the era of TNF-alpha inhibitors. METHODS: We conducted a retrospective review of 464 consecutive patients with CD in our GI clinic between 2008 and 2015...
December 13, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29235277/-targets-identification-and-mechanism-analysis-for-macrophage-activation-of-low-molecular-weight-saccharides-from-cistanche-deserticola-based-on-molecular-affinity-chromatography
#4
Li-Chao Wang, Dan Liu, Yong Jiang, Peng-Fei Tu, Ke-Wu Zeng
This study aims to investigate the targets and targets-involved mechanism for the macrophage activation of low molecular weight saccharides from Cistanche deserticola (LMSC). The phagocytic activity and NO release of RAW264.7 cells were detected, and results showed that LMSC exerts immune activation effect by significantly increasing the phagocytic activity and NO release. LMSC-conjugated epoxy-activated sepharose beads were prepared as affinity reagent to capture the target proteins. Twenty-four proteins such as Eef2 were identified by LC-MS/MS analysis...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234359/subtle-inflammation-a-possible-mechanism-of-future-cardiovascular-risk-in-obese-children
#5
Watchareewan Sontichai, Prapai Dejkhamron, Peraphan Pothacharoen, Prachya Kongtaweelert, Kevalee Unachak, Nuthapong Ukarapol
Purpose: The risk of cardiovascular disease (CVD) has been shown to be associated with systemic inflammation in obese adults with metabolic syndrome (MetS). The aims of this study were to evaluate the prevalence of MetS and its relation to inflammatory markers in obese Thai children. Methods: A cross-sectional study was conducted. Children with history of endogenous obesity, chronic diseases, drug ingestion, and any acute illness within 2 weeks prior to enrollment were excluded...
November 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29234328/forward-and-reverse-signaling-mediated-by-transmembrane-tumor-necrosis-factor-alpha-and-tnf-receptor-2-potential-roles-in-an-immunosuppressive-tumor-microenvironment
#6
REVIEW
Yang Qu, Gang Zhao, Hui Li
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α have been identified: soluble TNF-α (sTNF-α) and transmembrane TNF-α (mTNF-α). mTNF-α, which is the precursor of sTNF-α, can be cleaved by the TNF-α converting enzyme (TACE) and is released as sTNF-α. sTNF-α binds primarily to TNF receptor 1 (TNFR1) and plays an important role in the inflammatory immune response, whereas mTNF-α interacts primarily with TNF receptor 2 (TNFR2) and mediates the promotion of cellular proliferation and survival and other biological effects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29233029/molecular-hepatoprotective-effects-of-lipoic-acid-against-carbon-tetrachloride-induced-liver-fibrosis-in-rats-hepatoprotection-at-molecular-level
#7
K M Sadek, E A Saleh, S M Nasr
BACKGROUND: Liver fibrosis is a noteworthy well-being issue that can prompt the progression of liver cirrhosis and hepatocellular carcinoma. Prominently, many antioxidants have been shown to have defensive impacts against liver fibrosis. AIM: Subsequently, in the present study, the viability of alpha-lipoic acid (α-LA) in ensuring against carbon tetrachloride (CCl4)-actuated liver fibrosis and the mechanism(s) involved in this defensive impact were considered in rats...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29233026/evaluation-of-4-methyl-2-2-methylbenzyl-amino-1-3-thiazole-5-carboxylic-acid-against-hyperglycemia-insulin-sensitivity-and-oxidative-stress-induced-inflammatory-responses-and-%C3%AE-cell-damage-in-the-pancreas-of-streptozotocin-induced-diabetic-rats
#8
Y N Paudel, M R Ali, S Bawa, S Shah, M Adil, A Siddiqui, A S Basheer, M Q Hassan, M Sharma
4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitivity, oxidative stress, and inflammatory mediators were evaluated in streptozotocin (STZ)-induced neonatal models of non-insulin-dependent diabetes mellitus (NIDDM) rats where NIDDM was induced in neonatal pups with single intraperitoneal injection of STZ (100 mg/kg). The effect of BAC (10 and 20 mg/kg, p...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29233001/arachidonic-acid-attenuates-brain-damage-in-a-rat-model-of-ischemia-reperfusion-by-inhibiting-inflammatory-response-and-oxidative-stress
#9
Y Qu, H-L Zhang, X-P Zhang, H-L Jiang
The aim of the present study was to study the effects of arachidonic acid (ARA) in a rat brain ischemia/reperfusion model induced by middle cerebral artery occlusion (MCAO). A total of 50 rats were randomly divided into five groups: control group, MCAO group, MCAO + ARA 0.3 g/kg group, MCAO + ARA 1 g/kg group, and MCAO + ARA 3 g/kg group. The MCAO + ARA groups received ARA by intraperitoneal injection daily for 14 consecutive days, while the rats in the control and MCAO groups were given equivalent volume of saline...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29232407/temporal-changes-in-cardiac-oxidative-stress-inflammation-and-remodeling-induced-by-exercise-in-hypertension-role-for-local-angiotensin-ii-reduction
#10
Sebastião D Silva, Zaira P Jara, Roseli Peres, Larissa S Lima, Cristóforo Scavone, Augusto C Montezano, Rhian M Touyz, Dulce E Casarini, Lisete C Michelini
Exercise training reduces renin-angiotensin system (RAS) activation, decreases plasma and tissue oxidative stress and inflammation in hypertension. However, the temporal nature of these phenomena in response to exercise is unknown. We sought to determine in spontaneously hypertensive rats (SHR) and age-matched WKY controls the weekly effects of training on blood pressure (BP), plasma and left ventricle (LV) Ang II and Ang-(1-7) content (HPLC), LV oxidative stress (DHE staining), gene and protein expression (qPCR and WB) of pro-inflammatory cytokines, antioxidant enzymes and their consequence on hypertension-induced cardiac remodeling...
2017: PloS One
https://www.readbyqxmd.com/read/29232067/clinical-factors-are-associated-with-vitamin-d-levels-in-ibd-patients-a-retrospective-analysis
#11
Holger Schäffler, Martin Schmidt, Astrid Huth, Johannes Reiner, Änne Glass, Georg Lamprecht
INTRODUCTION: There is growing evidence for the hypothesis, that vitamin D deficiency plays a role in the development and the disease course of IBD. However, the correlation of vitamin D deficiency to clinical parameters in IBD is still not completely understood. MATERIAL AND METHODS: A retrospective study of IBD patients was performed. Vitamin D values were analyzed and correlated to clinical parameters like medical therapy, anatomical situation, localization of the disease and disease activity...
December 12, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29229953/dual-specificity-phosphatase-5-acts-as-an-anti-inflammatory-regulator-by-inhibiting-the-erk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#12
Huiyun Seo, Young-Chang Cho, Anna Ju, Sewoong Lee, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Kwonseop Kim, Sayeon Cho
Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles remain largely unknown. Here, we show that DUSP5 is induced during lipopolysaccharide (LPS)-mediated inflammation and inhibits nuclear factor-κB (NF-κB) activity. DUSP5 mRNA and protein expression increased transiently in LPS-stimulated RAW 264.7 cells and then returned to basal levels. DUSP5 overexpression in RAW 264.7 cells suppressed the production of pro-inflammatory tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), whereas knockdown of DUSP5 increased their expression...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229313/emerging-role-of-adipocytokines-in-type-2-diabetes-as-mediators-of-insulin-resistance-and-cardiovascular-disease
#13
REVIEW
Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya Dhanasekaran
Adipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines plays significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated by nutritional status and can directly influence other organ systems, including brain, liver and skeletal muscle...
December 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29228414/temporal-changes-of-inflammatory-cytokine-profiles-in-epithelial-lining-fluid-in-a-canine-lung-transplant-model
#14
Atsushi Wada, Mitsutomo Kohno, Kana Oiwa, Ryo Hashimoto, Takahisa Koizumi, Yusuke Nakamura, Tomoki Nakagawa, Ryota Masuda, Kichizo Kaga, Masayuki Iwazaki
OBJECTIVES: Ischemia-reperfusion injury resulting in post-transplant lung dysfunction involves a complicated network of cytokines that has yet to be fully investigated. We analyzed temporal changes in cytokine levels in epithelial lining fluid (ELF) from the distal airways of a canine lung transplantation model. METHODS: Ischemic time was set to 18 hours to enhance lung injury in a left single-lung transplantation model. ELF was collected via bronchoscopic microsampling, a minimally-invasive technique allowing repeated sampling, hourly up to 5 hours after reperfusion started...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29228352/tumour-necrosis-factor-alpha-in-uraemic-serum-promotes-osteoblastic-transition-and-calcification-of-vascular-smooth-muscle-cells-via-extracellular-signal-regulated-kinases-and-activator-protein-1-c-fos-mediated-induction-of-interleukin-6-expression
#15
Daniel Zickler, Christian Luecht, Kevin Willy, Lei Chen, Janusz Witowski, Matthias Girndt, Roman Fiedler, Markus Storr, Julian Kamhieh-Milz, Janosch Schoon, Sven Geissler, Olle Ringdén, Ralf Schindler, Guido Moll, Duska Dragun, Rusan Catar
Background: Vascular calcification is enhanced in uraemic chronic haemodialysis patients, likely due to the accumulation of midsize uraemic toxins, such as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Here we have assessed the impact of uraemia on vascular smooth muscle cell (VSMC) calcification and examined the role of IL-6 and TNF-α as possible mediators and, most importantly, its underlying signalling pathway in VSMCs. Methods: VSMCs were incubated with samples of uraemic serum obtained from patients treated with haemodialysis for renal failure in the Permeability Enhancement to Reduce Chronic Inflammation-I clinical trial...
December 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29227823/lncrna-malat1-regulates-sepsis-induced-cardiac-inflammation-and-dysfunction-via-interaction-with-mir-125b-and-p38-mapk-nf%C3%AE%C2%BAb
#16
Hu Chen, Xiaoyun Wang, Xuetao Yan, Xiaoli Cheng, Xianghu He, Wenzhong Zheng
This study aimed to explore the role of MALAT1 in sepsis-induced cardiac inflammation and dysfunction. We constructed the rat sepsis models through cecal ligation and puncture (CLP). The cardiac function, including left ventricular peak pressure (LVPP), left ventricular end diastolic pressure (LVEDP) and maximum rate of rise/fall of left ventricle pressure (±dp/dtmax) as well as the contents of serum cardiac troponin I (CTn-I), creatine kinase (CK), and creative kinase isoenzyme MB (CK-MB) were detected after modeling...
December 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29227717/quercetin-restores-corticosteroid-sensitivity-in-cells-from-patients-with-chronic-obstructive-pulmonary-disease
#17
Akihisa Mitani, Aishah Azam, Chaitanya Vuppusetty, Kazuhiro Ito, Nicolas Mercado, Peter J Barnes
Corticosteroid resistance is a major barrier to the effective treatment of chronic obstructive pulmonary disease (COPD). Oxidative stress from cigarette smoke and chronic inflammation is likely to induce this corticosteroid insensitivity. Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator. The aim of this study was to investigate the effect of quercetin on corticosteroid responsiveness in COPD cells...
December 11, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29227477/the-deubiquitinating-enzyme-tnfaip3-mediates-inactivation-of-hepatic-ask1-and-ameliorates-nonalcoholic-steatohepatitis
#18
Peng Zhang, Pi-Xiao Wang, Ling-Ping Zhao, Xin Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Chun Fang, Yue-Xin Lu, Xia Yang, Mao-Mao Gao, Yan Zhang, Song Tian, Xue-Yong Zhu, Jun Gong, Xin-Liang Ma, Feng Li, Zhihua Wang, Zan Huang, Zhi-Gang She, Hongliang Li
Activation of apoptosis signal-regulating kinase 1 (ASK1) in hepatocytes is a key process in the progression of nonalcoholic steatohepatitis (NASH) and a promising target for treatment of the condition. However, the mechanism underlying ASK1 activation is still unclear, and thus the endogenous regulators of this kinase remain open to be exploited as potential therapeutic targets. In screening for proteins that interact with ASK1 in the context of NASH, we identified the deubiquitinase tumor necrosis factor alpha-induced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activation, and we found that TNFAIP3 directly interacts with and deubiquitinates ASK1 in hepatocytes...
December 11, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29227181/effects-of-fuel-components-and-combustion-particle-physicochemical-properties-on-toxicological-responses-of-lung-cells
#19
Isabel C Jaramillo, Anne Sturrock, Hossein Ghiassi, Diana J Woller, Cassandra E Deering-Rice, JoAnn S Lighty, Robert Paine, Christopher Reilly, Kerry E Kelly
The physicochemical properties of combustion particles that promote lung toxicity are not fully understood, hindered by the fact that combustion particles vary based on the fuel and combustion conditions. Real-world combustion-particle properties also continually change as new fuels are implemented, engines age, and engine technologies evolve. This work used laboratory-generated particles produced under controlled combustion conditions in an effort to understand the relationship between different particle properties and the activation of established toxicological outcomes in human lung cells (H441 and THP-1)...
December 11, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29225991/administration-of-protein-kinase-d1-induces-a-protective-effect-on-lipopolysaccharide-induced-intestinal-inflammation-in-a-co-culture-model-of-intestinal-epithelial-caco-2-cells-and-raw264-7-macrophage-cells
#20
Ditte Søvsø Gundelund Nielsen, Marlene Fredborg, Vibeke Andersen, Stig Purup
Inflammatory bowel diseases (IBD) are chronic inflammatory diseases involving all or part of the gastrointestinal tract. The stress-activated serine-threonine protein kinase D1 (PKD1) protein has previously been implicated in intestinal immune regulation. The objective of this study was to evaluate the effects of human PKD1 in relation to intestinal inflammation, using a co-culture model of intestinal epithelial Caco-2 cells and RAW264.7 macrophages. An inflammatory response was induced in the macrophages by lipopolysaccharide (LPS), upregulating the expression of tumour necrosis factor alpha (TNF-α), interleukin- (IL-) 1β, and IL-6 besides increasing the secretion of TNF-α protein...
2017: International Journal of Inflammation
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