keyword
MENU ▼
Read by QxMD icon Read
search

tnf alpha

keyword
https://www.readbyqxmd.com/read/29933208/inhibition-on-angiotensin-converting-enzyme-exerts-beneficial-effects-on-trabecular-bone-in-orchidectomized-mice
#1
Xiang-Fan Chen, Xiao-Li Li, Jin-Xin Liu, Jing Xu, Yan-Yan Zhao, Min Yang, Yan Zhang
BACKGROUND: This study aimed to study the osteo-preservative effects of captopril, an inhibitor on angiotensin-converting enzyme (ACE), on bone mass, micro-architecture and histomorphology as well as the modulation of captopril on skeletal renin-angiotensin system (RAS) and regulators for bone metabolism in mice with bilateral orchidectomy. METHODS: The orchidectomized (ORX) mice were orally administered with vehicle or captopril at low dose (10 mg/kg) and high dose (50 mg/kg) for six weeks...
February 7, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29933031/social-influences-on-microglial-reactivity-and-neuronal-damage-after-cardiac-arrest-cardiopulmonary-resuscitation
#2
Monica M Gaudier-Diaz, Adam H Haines, Ning Zhang, A Courtney DeVries
Social isolation presents a risk factor and worsens outcome to cerebrovascular diseases; however, the underlying mechanisms remain underspecified. This study examines the effect of social environment on microglial reactivity after global cerebral ischemia, to test the hypothesis that social isolation leads to greater microglial responses. Adult female and male mice were pair-housed or socially isolated for one week prior to cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or the sham procedure, and following either 2 or 24 h of reperfusion, microglia samples were enriched and analyzed for gene expression...
June 19, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29932796/defective-dendritic-cell-cytotoxic-activity-of-high-grade-glioma-patients-results-from-the-low-expression-of-membrane-tnf%C3%AE-and-can-be-corrected-in-vitro-by-treatment-with-recombinant-il-2-or-exogenic-double-stranded-dna
#3
Tamara Tyrinova, Olga Leplina, Sergey Mishinov, Marina Tikhonova, Anton Kalinovskiy, Sergey Chernov, Evgeniya Dolgova, Vyacheslav Stupak, Evgeniya Voronina, Sergey Bogachev, Ekaterina Shevela, Alexander Ostanin, Elena Chernykh
Besides initiation of tumor-specific T cell immunity, dendritic cells (DCs) are endowed with tumoricidal activity. Previously, we showed that monocyte-derived DCs of high-grade glioma patients generated in the presence of interferon alpha (IFNα) (IFN-DCs) have impaired cytotoxic activity against tumor necrosis factor alpha (TNFα)-sensitive HEp-2 tumor cells. Herein, we demonstrate that decreased transmembrane TNFα (tmTNFα) expression, but not soluble TNFα (sTNFα) production by high-grade glioma patient IFN-DCs, determines the defective tumoricidal activity against TNFα-sensitive HEp-2 cells...
June 22, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29932162/ethanolic-extracts-of-artemisia-apiacea-hance-improved-atopic-dermatitis-like-skin-lesions-in-vivo-and-suppressed-tnf-alpha-ifn-gamma%C3%A2-induced-proinflammatory-chemokine-production-in-vitro
#4
Ju-Hye Yang, Esther Lee, BoHyoung Lee, Won-Kyung Cho, Jin Yeul Ma, Kwang-Il Park
Artemisia apiacea Hance is a traditional herbal medicine used for treating eczema and jaundice in Eastern Asia including China, Korea, and Japan. However, the biological and pharmacological actions of Artemisia apiacea Hance in atopic dermatitis (AD) are not fully understood. An ethanolic extract of Artemisia apiacea Hance (EAH) was tested in vitro and in vivo to investigate its anti-inflammatory activity and anti-atopic dermatitis effects. The results showed that EAH dose-dependence inhibited production of regulated on activation, normal T-cell expressed and secreted (RANTES), interleukin (IL)-6, IL-8, and thymus and activation-regulated chemokine (TARC)...
June 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29932135/-epicatechin-reduces-blood-pressure-and-improves-left-ventricular-function-and-compliance-in-deoxycorticosterone-acetate-salt-hypertensive-rats
#5
Douglas Jackson, Kylie Connolly, Romeo Batacan, Kimberly Ryan, Rebecca Vella, Andrew Fenning
(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study investigated the effect of 28 days of low epicatechin dosing (1 mg/kg/day) on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Wistar rats (n = 120, 8 weeks of age) underwent uninephrectomy and were randomised into four groups (uninephrectomy (UNX), UNX + E, DOCA, DOCA + E)...
June 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29930690/the-effects-of-alpha-lipoic-acid-supplementation-on-inflammatory-markers-among-patients-with-metabolic-syndrome-and-related-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Maryam Akbari, Vahidreza Ostadmohammadi, Reza Tabrizi, Moein Mobini, Kamran B Lankarani, Mahmood Moosazadeh, Seyed Taghi Heydari, Maryam Chamani, Fariba Kolahdooz, Zatollah Asemi
Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders. Methods: We searched the following databases until November 2017: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Three reviewers independently assessed study eligibility, extracted data, and evaluated risk of bias of included primary studies...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29927631/therapeutic-effects-of-the-addition-of-platelet-rich-plasma-to-bioimplants-and-early-rehabilitation-exercise-on-articular-cartilage-repair
#7
Nai-Jen Chang, Yanjmaa Erdenekhuyag, Pei-Hsi Chou, Chih-Jou Chu, Chih-Chan Lin, Ming-You Shie
BACKGROUND: Treating articular cartilage lesions is clinically challenging. However, whether the addition of autologous platelet-rich plasma (PRP) to bioimplants along with early rehabilitation exercise provides therapeutic effects and regenerates the osteochondral defect remains uninvestigated. HYPOTHESIS: The addition of PRP to a polylactic-co-glycolic acid (PLGA) scaffold along with continuous passive motion (CPM) in osteochondral defects may offer beneficial in situ microenvironment changes to facilitate hyaline cartilage and subchondral bone tissue repair...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29926368/the-effect-of-periodontal-disease-treatment-in-patients-with-continuous-ambulatory-peritoneal-dialysis
#8
Zekeriya Tasdemir, Funda Özsarı Tasdemir, Cem Gürgan, Eray Eroglu, Inayet Gunturk, Ismail Kocyigit
PURPOSE: Chronic inflammation is an obvious risk factor of atherosclerotic diseases, and the presence of periodontal disease is one of the important sources of chronic inflammation in patients with chronic kidney disease (CKD) and diabetes mellitus (DM). Thus, we aimed to investigate the effects of non-surgical periodontal therapy of the patients undergoing CAPD due to diabetic nephropathy, diabetic patients without CKD, and healthy controls on inflammation exponents. METHODS: Thirty-two CAPD patients due to diabetic nephropathy (group III), 31 diabetic patients without nephropathy (group II), and 38 healthy subjects (group I) were enrolled to the study...
June 20, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29925772/lead-pb-exposure-enhances-expression-of-factors-associated-with-inflammation
#9
REVIEW
Emilia Metryka, Karina Chibowska, Izabela Gutowska, Anna Falkowska, Patrycja Kupnicka, Katarzyna Barczak, Dariusz Chlubek, Irena Baranowska-Bosiacka
The human immune system is constantly exposed to xenobiotics and pathogens from the environment. Although the mechanisms underlying their influence have already been at least partially recognized, the effects of some factors, such as lead (Pb), still need to be clarified. The results of many studies indicate that Pb has a negative effect on the immune system, and in our review, we summarize the most recent evidence that Pb can promote inflammatory response. We also discuss possible molecular and biochemical mechanisms of its proinflammatory action, including the influence of Pb on cytokine metabolism (interleukins IL-2, IL-4, IL-8, IL-1b, IL-6), interferon gamma (IFNγ), and tumor necrosis factor alpha (TNF-α); the activity and expression of enzymes involved in the inflammatory process (cyclooxygenases); and the effect on selected acute phase proteins: C-reactive protein (CRP), haptoglobin, and ceruloplasmin...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29925372/selenium-ameliorates-staphylococcus-aureus-induced-inflammation-in-bovine-mammary-epithelial-cells-by-inhibiting-activation-of-tlr2-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#10
Heng Wang, Chongliang Bi, Yinjie Wang, Jun Sun, Xia Meng, Jianji Li
BACKGROUND: Staphylococcus aureus (S. aureus) internalization into bovine mammary epithelial cells (bMECs) is considered an important pathogenic mechanism for the establishment of mastitis. Given the interesting link between selenium (Se) status and mastitis, our objective was to prove that Se was essential to suppress pro-inflammatory mediators, in part, by modulation of Toll-like receptor2 (TLR2), nuclear factor kappaB (NF-κB) and mitogen activated protein kinase (MAPK) signal transduction pathway in bMECs...
June 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29923217/expression-of-the-ectodomain-releasing-protease-adam17-is-directly-regulated-by-the-osteosarcoma-and-bone-related-transcription-factor-runx2
#11
Héctor F Araya, Hugo Sepulveda, Carlos O Lizama, Oscar A Vega, Sofia Jerez, Pedro F Briceño, Roman Thaler, Scott M Riester, Marcelo Antonelli, Flavio Salazar-Onfray, Juan Pablo Rodríguez, Ricardo D Moreno, Martin Montecino, Martine Charbonneau, Claire M Dubois, Gary S Stein, Andre J van Wijnen, Mario A Galindo
Osteoblast differentiation is controlled by transcription factor RUNX2 which temporally activates or represses several bone-related genes, including those encoding extracellular matrix proteins or factors that control cell-cell, and cell-matrix interactions. Cell-cell communication in the many skeletal pericellular micro-niches is critical for bone development and involves paracrine secretion of growth factors and morphogens. This paracrine signaling is in part regulated by "A Disintegrin And Metalloproteinase" (ADAM) proteins...
June 19, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29922282/cord-blood-cd8-t-cells-have-a-natural-propensity-to-express-il-4-in-a-fatty-acid-metabolism-and-caspase-activation-dependent-manner
#12
Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison
How T cells differentiate in the neonate may critically determine the ability of the infant to cope with infections, respond to vaccines and avert allergies. Previously, we found that naïve cord blood CD4+ T cells differentiated toward an IL-4-expressing phenotype when activated in the presence of TGF-β and monocyte-derived inflammatory cytokines, the latter are more highly secreted by infants who developed food allergy. Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic TC 2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29922174/diet-induced-obesity-affects-muscle-regeneration-after-murine-blunt-muscle-trauma-a-broad-spectrum-analysis
#13
Pengfei Xu, Jens-Uwe Werner, Sebastian Milerski, Carmen M Hamp, Tatjana Kuzenko, Markus Jähnert, Pascal Gottmann, Luisa de Roy, Daniela Warnecke, Alireza Abaei, Annette Palmer, Markus Huber-Lang, Lutz Dürselen, Volker Rasche, Annette Schürmann, Martin Wabitsch, Uwe Knippschild
Injury to skeletal muscle affects millions of people worldwide. The underlying regenerative process however, is a very complex mechanism, time-wise highly coordinated, and subdivided in an initial inflammatory, a regenerative and a remodeling phase. Muscle regeneration can be impaired by several factors, among them diet-induced obesity (DIO). In order to evaluate if obesity negatively affects healing processes after trauma, we utilized a blunt injury approach to damage the extensor iliotibialis anticus muscle on the left hind limb of obese and normal weight C57BL/6J without showing any significant differences in force input between normal weight and obese mice...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29922080/factors-correlated-with-the-improvement-of-endothelial-dysfunction-during-abatacept-therapy-in-patients-with-rheumatoid-arthritis
#14
Maurizio Benucci, Francesca Bandinelli, Arianna Damiani, Francesca Li Gobbi, Maria Infantino, Valentina Grossi, Mariangela Manfredi
Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease. Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of prednisone 5.2±1.2 mg/day and Methotrexate 11.5±2.1 mg at baseline (T0) and after 12 months (T1) of treatment with Abatacept 125 mg/week...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29921762/tb-ii-i-a-fraction-isolated-from-tityus-bahiensis-scorpion-venom-alters-cytokines-level-and-induces-seizures-when-intrahippocampally-injected-in-rats
#15
Emidio Beraldo Neto, Douglas O C Mariano, Lucas A Freitas, Ana L C Dorce, Adriana N Martins, Daniel C Pimenta, Fernanda C V Portaro, Daniela Cajado-Carvalho, Valquiria A C Dorce, Ana L A Nencioni
Scorpion venoms are composed of several substances with different pharmacological activities. Neurotoxins exert their effects by targeting ion channels resulting in toxic effects to mammals, insects and crustaceans. Tb II-I, a fraction isolated from Tityus bahiensis scorpion venom, was investigated for its ability to induce neurological and immune-inflammatory effects. Two putative β-sodium channel toxins were identified in this fraction, Tb2 II and Tb 4, the latter having been completely sequenced by mass spectrometry...
June 19, 2018: Toxins
https://www.readbyqxmd.com/read/29921749/role-of-human-macrophage-polarization-in-inflammation-during-infectious-diseases
#16
REVIEW
Chiraz Atri, Fatma Z Guerfali, Dhafer Laouini
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1-like and M2-like macrophages is rather represented by a continuum, where boundaries are still unclear. Indeed, human infectious diseases, are characterized by either a back and forth or often a mixed profile between the pro-inflammatory microenvironment (dominated by interleukin (IL)-1β, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-α cytokines) and tissue injury driven by classically activated macrophages (M1-like) and wound healing driven by alternatively activated macrophages (M2-like) in an anti-inflammatory environment (dominated by IL-10, Transforming growth factor (TGF)-β, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22)...
June 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29921748/desmoglein1-deficiency-is-a-potential-cause-of-cutaneous-eruptions-induced-by-shuanghuanglian-injection
#17
Yidan Zhang, Xiujun Zhang, Shanshan Fan, Lili Song, Zhen Yang, Pengwei Zhuang, Yanjun Zhang
Cutaneous eruption is a common drug-adverse reaction, characterised by keratinocytes inflammation and apoptosis. Shuanghuanglian injeciton (SHLI) is a typical Chinese medicine injection, which is used to treat influenza. It has been reported that SHLI has the potential to induce cutaneous adverse eruptions. However, the mechanisms remain unclear. Since desmoglein 1 (DSG1) shows a crucial role in maintaining skin barrier function and cell susceptibility, we assume that DSG1 plays a critical role in the cutaneous eruptions induced by SHLI...
June 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29921584/toll-interacting-protein-differentially-modulates-hif1%C3%AE-and-stat5-mediated-genes-in-fibroblasts
#18
Elizabeth Kowalski, Shuo Geng, Allison Rahtes, Ran Lu, Liwu Li
Toll-interacting protein (Tollip) deficiency has been implicated in complex inflammatory and infectious diseases whose mechanisms are poorly understood. Comparing the gene expression profiles of WT and Tollip-deficient murine embryonic fibroblasts, we observed here that Tollip deficiency selectively reduces the expression of the inflammatory cytokines interleukin 6 (IL-6), IL-12, and tumor necrosis factor α (TNFα), but potentiates the expression of fatty acid-binding protein 4 (FABP4) in these cells. We also observed that expression of hypoxia-inducible factor 1-alpha (HIF1α) is reduced, whereas that of signal transducer and activator of transcription 5 (STAT5) is elevated, in Tollip-deficient cells, correlating with the decreased expression of inflammatory cytokines and increased expression of FABP4 in these cells...
June 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29920327/maternal-prenatal-depression-predicts-infant-negative-affect-via-maternal-inflammatory-cytokine-levels
#19
Hanna C Gustafsson, Elinor L Sullivan, Elizabeth K Nousen, Ceri A Sullivan, Elaine Huang, Monica Rincon, Joel T Nigg, Jennifer M Loftis
Maternal depressive symptoms during pregnancy are associated with risk for offspring emotional and behavioral problems, but the mechanisms by which this association occurs are not known. Infant elevated negative affect (increased crying, irritability, fearfulness, etc.) is a key risk factor for future psychopathology, so understanding its determinants has prevention and early intervention potential. An understudied yet promising hypothesis is that maternal mood affects infant mood via maternal prenatal inflammatory mechanisms, but this has not been prospectively examined in humans...
June 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29917063/sodium-intake-is-associated-with-endothelial-damage-biomarkers-and-metabolic-dysregulation
#20
Carmen Campino, Rene Baudrand, Carolina Valdivia, Cristian Carvajal, Andrea Vecchiola, Alejandra Tapia-Castillo, Alejandro Martínez-Aguayo, Hernán Garcia, Lorena García, Fidel Allende, Sandra Solari, Cristóbal Fuentes, Calos F Lagos, Maria Paulina Rojas, Doris Muñoz, Carlos Fardella
Background: Mounting evidence has associated high sodium intake with hypertension, cardiovascular disease and stroke. We investigated whether high sodium intake modulates the parameters of endothelial damage, inflammation and oxidative stress. Methods: We used a cross-sectional study design including 223 Chilean subjects (6.9-65.0 years old). We measured aldosterone, renin activity, cortisol, cortisone, adiponectin, leptin, hs-CRP, IL-6, TNF-alpha, PAI-1, metalloproteinase (MMP)-9 and MMP-2 activity and malondialdehyde (MDA)...
June 16, 2018: American Journal of Hypertension
keyword
keyword
26689
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"