keyword
MENU ▼
Read by QxMD icon Read
search

tnf alpha

keyword
https://www.readbyqxmd.com/read/29679637/recent-stimulant-use-and-leukocyte-gene-expression-in-methamphetamine-users-with-treated-hiv-infection
#1
Adam W Carrico, Annesa Flentje, Kord Kober, Sulggi Lee, Peter Hunt, Elise D Riley, Steven Shoptaw, R N Elena Flowers, Samantha E Dilworth, Savita Pahwa, Bradley E Aouizerat
Stimulant use may accelerate HIV disease progression through biological and behavioral pathways. However, scant research with treated HIV-positive persons has examined stimulant-associated alterations in pathophysiologic processes relevant to HIV pathogenesis. In a sample of 55 HIV-positive, methamphetamine-using sexual minority men with a viral load less than 200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene expression in participants who had a urine sample that was reactive for stimulants (n = 27) as compared to those who tested non-reactive (n = 28)...
April 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29678518/pattern-recognition-receptors-mediate-pro-inflammatory-effects-of-extracellular-mitochondrial-transcription-factor-a-tfam
#2
Stephanie M Schindler, Matthew G Frank, Jessica L Annis, Steven F Maier, Andis Klegeris
Neuroinflammation is a common pathogenic mechanism for a number of neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Microglia, the immune cells of the brain, contribute to the onset and progression of the neuroinflammation observed in these diseases. Microglia become activated and initiate an inflammatory response by interacting with a diverse set of molecules, including the group of endogenous proteins released upon cell damage, termed damage-associated molecular patterns (DAMPs)...
April 17, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#3
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29677563/polysaccharide-of-hericium-erinaceus-attenuates-colitis-in-c57bl-6-mice-via-regulation-of-oxidative-stress-inflammation-related-signaling-pathways-and-modulating-the-composition-of-the-gut-microbiota
#4
Yilin Ren, Yan Geng, Yan Du, Wang Li, Zhen-Ming Lu, Hong-Yu Xu, Guo-Hua Xu, Jin-Song Shi, Zheng-Hong Xu
Inflammatory bowel disease (IBD) is a disease caused by a dysregulated immune with unknown etiology. Hericium erinaceus (H. erinaceus) is a Chinese medicinal fungus, with the effect of prevention and treatment of gastrointestinal disorders. In this study, we have tested the anti-inflammatory effect of polysaccharide of H. erinaceus (HECP, Mw: 86.67 kDa) in the model of dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. Our data indicated that HECP could improve clinical symptoms and down-regulate key markers of oxidative stresses, including nitric oxide (NO), malondialdehyde (MDA), total superoxide dismutase (T-SOD), and myeloperoxidase (MPO)...
March 16, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29677454/combined-but-not-the-single-administration-of-vitamin-c-and-l-carnitine-ameliorates-cisplatin-induced-gastric-mucosa-damage-in-male-rats
#5
Modinat Adebukola Adefisayo, Wale Johnson Adeyemi, Quadri Kunle Alabi
Although cisplatin is a potent anticancer drug, it instigates oxidative and pro-inflammatory reactions which poses significant and distressing clinical symptoms in patients including nausea and vomiting which is related to damage of the gastric mucosa. This study investigated the effects of vitamin C and/or L-carnitine on cisplatin-induced gastric mucosa damage in rat. The rats were allocated into groups (n=5): a control group received distilled water and treatment groups received cisplatin (CIP) alone, cisplatin followed by vitamin C, L-carnitine or their combination...
April 20, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29676293/association-between-polymorphism-of-tumor-necrosis-factor-alpha-tnf%C3%AE-in-the-region-308-g-a-with-tinnitus-in-the-elderly-with-a-history-of-occupational-noise-exposure
#6
Luciana L M Marchiori, Ana C M Dias, Alyne S Gonçalvez, Regina C Poly-Frederico, Marcelo Y Doi
Context: Tinnitus is a common disorder that occurs frequently across all strata of population and has an important health concern and is often associated with different forms of the hearing loss of varying severity. Aims: To investigate the association between the polymorphism of tumor necrosis factor alpha (TNFα) in the region -308 G/A with the susceptibility to tinnitus in individuals with the history of exposure to occupational noise. Settings and Design: This was a cross-sectional study with a sample of 179 independent elderly people above 60 years of age...
March 2018: Noise & Health
https://www.readbyqxmd.com/read/29676105/-effects-of-tongbi-capsule-on-joint-lesions-in-rabbits-with-rheumatoid-arthritis
#7
Qing-Yong Cao, Pei-Yuan Wang, Qiao-Yun Wang, Feng Zhao, Ke-Zhan Wang, Jun-Qi Liu, Tong-Shen Liu, Yuan-Fang Wang, Yong-Jun Liu
The purpose of this experiment is to observe the effects of Tongbi capsule on joint lesions in rabbit with rheumatoid arthritis induced by ovalbumin and explore the mechanism in order to provide reference for clinical application of Tongbi capsule. Rheumatoid arthritis in rabbits was induced by subcutaneous injection of emulsions of ovalbumin and Freund's complete adjuvant and intra articular injection of ovalbumin. After successful modeling, 30 New Zealand rabbits with arthritis were randomly divided into model control group, the high, medium and low dose groups of Tongbi capsule (90, 45, 22...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675912/tumor-necrosis-factor-%C3%AE-308-g-a-and-interleukin-1-%C3%AE-511-c-t-gene-polymorphisms-in-patients-with-scarring-acne
#8
Gulsen Akoglu, Cagman Tan, Deniz Cagdas Ayvaz, Ilhan Tezcan
BACKGROUND: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C<T polymorphisms. AIM: To evaluate the association of TNF α-308 and IL-1β-511 gene polymorphisms with acne and postacne scarring susceptibility and acne severity...
April 19, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29675435/serum-levels-of-interleukin-13-increase-in-subjects-with-insulin-resistance-but-do-not-correlate-with-markers-of-low-grade-systemic-inflammation
#9
Camilo P Martínez-Reyes, Angélica Y Gómez-Arauz, Israel Torres-Castro, Aarón N Manjarrez-Reyna, León F Palomera, Alfonso Olivos-García, Edith Mendoza-Tenorio, Gabriela A Sánchez-Medina, Sergio Islas-Andrade, Guillermo Melendez-Mier, Galileo Escobedo
Experimental evidence in mice suggests a role for interleukin- (IL-) 13 in insulin resistance and low-grade systemic inflammation. However, IL-13 serum levels have not been assessed in subjects with insulin resistance, and associations of IL-13 with parameters of low-grade systemic inflammation are still unknown. Our main goal was to examine the systemic levels of IL-13 in patients with insulin resistance, while also studying the relationship of IL-13 with anthropometric, metabolic, and low-grade systemic inflammatory markers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29675026/multiplex-cytokine-analysis-of-aqueous-humor-in-juvenile-idiopathic-arthritis-associated-anterior-uveitis-with-or-without-secondary-glaucoma
#10
Dirk Bauer, Maren Kasper, Karoline Walscheid, Jörg M Koch, Philipp S Müther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten Heinz
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29673161/biflavonoids-isolated-from-selaginella-tamariscina-and-their-anti-inflammatory-activities-via-erk-1-2-signaling
#11
Sun-Yup Shim, Seul-Gi Lee, Mina Lee
Selaginella tamariscina ( S. tamariscina ) (Beauv.) Spring (Selaginellaceae) has been used in oriental medicine for the treatment of dysmenorrhea, chronic hepatitis, hyperglycemia, amenorrhea, hematuria, prolapse of the anus and metrorrhagia. In the present study, we isolated two strong anti-inflammatory compounds, the biflavonoids hinokiflavone (H) and 7&prime;- O -methyl hinokiflavone (mH), from S. tamariscina and examined their anti-inflammatory activities in lipopolysaccharide (LPS)-mediated murine macrophages (RAW 264...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29672133/meat-eggs-full-fat-dairy-and-nutritional-boogeymen-does-the-way-in-which-animals-are-raised-affect-health-differently-in-humans
#12
Christopher P Haskins, George Henderson, Colin E Champ
BACKGROUND:  Food recommendations to improve cancer prevention are generally based on epidemiologic data and remain inconsistent. These epidemiologic studies, while controversial, have generally produced results that caution against the consumption of high-fat foods, including eggs, red meat, and full-fat dairy, such as butter and cheese. Yet, limited data exist assessing the quality of individual sources of these foods and the effect each has after its consumption. This study set out to assess the impact sources of food within the same groups from animals raised differently on variables associated with health in human studies...
April 19, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29671019/lixisenatide-a-novel-glp-1-analog-protects-against-cerebral-ischemia-reperfusion-injury-in-diabetic-rats
#13
Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalifa
Type 2 diabetes mellitus (T2DM) is a major risk factor for ischemic stroke accompanied by vascular dysfunction and poor cerebrovascular outcome. Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties. This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury. T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29670828/high-expression-of-the-hmgb1-tlr4-axis-and-its-downstream-signaling-factors-in-patients-with-parkinson-s-disease-and-the-relationship-of-pathological-staging
#14
Yi Yang, Chenyang Han, Li Guo, Qiaobin Guan
Objective: To detect the expression of high-mobility group box protein 1 (HMGB1) and toll-like receptor 4 (TLR4) and their downstream signaling factors-myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-κB), and tumor necrosis factor alpha (TNF-α)-in the sera of patients with Parkinson's disease (PD) in order to evaluate the relationship of the HMGB1-TLR4 axis with PD development and progression. Methods: The serum HMGB1 and TLR4 protein levels of 120 patients with PD and 100 healthy volunteers were measured using double-antibody sandwich ELISA, and their correlations with PD staging, disease duration, drug treatment effectiveness, and clinical classification were analyzed...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29669327/effects-of-baicalin-on-diabetic-cardiac-autonomic-neuropathy-mediated-by-the-p2y12-receptor-in-rat-stellate-ganglia
#15
Xuan Sheng, Jiayue Wang, Jingjing Guo, Yurong Xu, Huaide Jiang, Chaoran Zheng, Zixi Xu, Yuanruohan Zhang, Hongyu Che, Shangdong Liang, Gaochun Zhu, Guilin Li
BACKGROUND/AIMS: Chronic diabetic hyperglycemia can damage various of organ systems and cause serious complications. Although diabetic cardiac autonomic neuropathy (DCAN) is the primary cause of death in diabetic patients, its pathogenesis remains to be fully elucidated. Baicalin is a flavonoid extracted from Scutellaria baicalensis root and has antibacterial, diuretic, anti-inflammatory, anti- metamorphotic, and antispasmodic effects. Our study explored the effects of baicalin on enhancing sympathoexcitatory response induced by DCAN via the P2Y12 receptor...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29669006/gene-signature-based-approach-identified-mek1-2-as-a-potential-target-associated-with-relapse-after-anti-tnf%C3%AE-treatment-for-crohn-s-disease
#16
Kanae Gamo, Yuumi Okuzono, Masato Yabuki, Takashi Ochi, Kyoko Sugimura, Yosuke Sato, Masaki Sagara, Hiroki Hayashi, Yoshimasa Ishimura, Yutaka Nishimoto, Yusuke Murakawa, Zenyu Shiokawa, Masayuki Gotoh, Takahiro Miyazaki, Yukihiko Ebisuno
Background: Anti-tumor necrosis factor alpha (anti-TNFα) therapy has become the mainstay of therapy for Crohn's disease (CD). However, post-therapy, the recurrence rate is still high. The aim of this study was to dissect the molecular mechanism for recurrence of CD treated with anti-TNFα therapy and investigate novel therapeutic options that could induce complete remission. Methods: We re-analyzed publicly available mucosal gene expression data from CD patients pre- and post-infliximab therapy to extract the transcriptional differences between responders and healthy controls...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668928/akkermansia-muciniphila-can-reduce-the-damage-of-gluco-lipotoxicity-oxidative-stress-and-inflammation-and-normalize-intestine-microbiota-in-streptozotocin-induced-diabetic-rats
#17
Ling Zhang, Qianqian Qin, Manni Liu, Xiangling Zhang, Fang He, Guoqing Wang
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying the effects Akkermansia muciniphila on type 2 diabetes mellitus. Normal and streptozotocin-induced diabetic Sprague-Dawley rats were orally administered with Akkermansia muciniphila and solvent. After four weeks of treatment, diabetic rats orally administered with live or pasteurized Akkermansia muciniphila exhibited significant increase in the blood concentration of high-density lipoprotein, and decrease in the hepatic glycogen, serum plasminogen activator inhibitor-1, tumor necrosis factor-α, lipopolysaccharide, malondialdehyde, and total glucagon-like peptide-1...
April 16, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29668324/tumor-necrosis-factor-alpha-potentiates-the-effects-of-angiotensin-ii-on-subfornical-organ-neurons
#18
Nick James Simpson, Alastair V Ferguson
Inflammation is thought to play a fundamental role in the pathophysiology of hypertension and heart failure, though the mechanisms for this remain unclear. Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα), influence the subfornical organ (SFO) to modulate sympathetic activity and blood pressure. The pressor effects of TNFα in the SFO are partially mediated by angiotensin II (Ang II) receptor type 1 (AT1 R), and TNFα is known to potentiate Ang II-induced hypertension. However, the cellular mechanism of the interaction between TNFα and Ang II/AT1 R signaling remains unknown...
April 18, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29668263/neuroprotective-effect-of-alpha-linolenic-acid-against-a%C3%AE-mediated-inflammatory-responses-in-c6-glial-cell
#19
Ah Young Lee, Myoung Hee Lee, Sanghyun Lee, Eun Ju Cho
Therapeutic approaches for neurodegeneration, such as Alzheimer's disease (AD), have been widely studied. One of the critical hallmarks of AD is accumulation of amyloid beta (Aβ). Aβ induces neurotoxicity and releases inflammatory mediators or cytokines through activation of glial cell, and these pathological features are observed in AD patient's brain. The purpose of this study is to investigate the protective effect of alpha-linolenic acid (ALA) on Aβ25-35 -induced neurotoxicity in C6 glial cells. Exposure of C6 glial cells to 50 μM 25-35 caused cell death, over-production of nitric oxide (NO), and pro-inflammatory cytokines release [interleukin (IL)-6 and tumor necrosis factor-α], while treatment of ALA increased cell viability and markedly attenuated Aβ25-35 -induced excessive production of NO and those inflammatory cytokines...
April 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29668129/-tuberculosis-in-the-era-of-anti-tnf-alpha-therapy-why-does-the-risk-still-exist
#20
John-Leonardo Torres-Castiblanco, Jorge Alberto Carrillo, Daniel Hincapié-Urrego, Adriana Rojas-Villarraga
Rheumatoid arthritis is an autoimmune systemic disease characterized mainly by inflammatory compromise of diarthrodial joints. Multiple drug therapies have been developed to control the activity of rheumatoid arthritis, among them, the first line of disease-modifying antirheumatic drugs (DMARD), and novel drug therapies such as the anti-TNF alpha therapy, with satisfactory clinical outcomes.Despite this positive fact, the use of this therapy implies the risk of producing negative effects due to its mechanism of action, which has been associated with multiple infections, especially tuberculosis, making it necessary to use screen tests before resorting to this kind of drugs...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
keyword
keyword
26689
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"