Ylva Gustafsson, Johannes Haag, Philipp Jungebluth, Vanessa Lundin, Mei Ling Lim, Silvia Baiguera, Fatemeh Ajalloueian, Costantino Del Gaudio, Alessandra Bianco, Guido Moll, Sebastian Sjöqvist, Greg Lemon, Ana Isabel Teixeira, Paolo Macchiarini
In 2011, the first in-man successful transplantation of a tissue engineered trachea-bronchial graft, using a synthetic POSS-PCU nanocomposite construct seeded with autologous stem cells, was performed. To further improve this technology, we investigated the feasibility of using polymers with a three dimensional structure more closely mimicking the morphology and size scale of native extracellular matrix (ECM) fibers. We therefore investigated the in vitro biocompatibility of electrospun polyethylene terephthalate (PET) and polyurethane (PU) scaffolds, and determined the effects on cell attachment by conditioning the fibers with adhesion proteins...
November 2012: Biomaterials