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Nature medicine

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https://www.readbyqxmd.com/read/28454485/cheminformatics-based-anticoagulant-study-of-traditionally-used-medicinal-plants
#1
Mahdi Alikhani Pour, Soroush Sardari, Ali Eslamifar, Abid Azhar, Mohammad Rezvani, Milad Nazari
Backgroung: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. Methods: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists...
April 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28453828/examining-the-nature-of-interprofessional-interventions-designed-to-promote-patient-safety-a-narrative-review
#2
Scott Reeves, Emma Clark, Sally Lawton, Melissa Ream, Fiona Ross
Purpose: This narrative review aimed to scope the patient safety literature to identify interprofessional intervention approaches, sources of evidence and reported outcomes. Data sources: Two major databases (MEDLINE and CINAHL) were searched from 2005 to 2015. Study selection: A total of 1552 abstracts were initially identified. After screening these abstracts, 129 full papers were obtained. Further screening resulted in a total of 89 papers included in this review...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28453650/plantismash-automated-identification-annotation-and-expression-analysis-of-plant-biosynthetic-gene-clusters
#3
Satria A Kautsar, Hernando G Suarez Duran, Kai Blin, Anne Osbourn, Marnix H Medema
Plant specialized metabolites are chemically highly diverse, play key roles in host-microbe interactions, have important nutritional value in crops and are frequently applied as medicines. It has recently become clear that plant biosynthetic pathway-encoding genes are sometimes densely clustered in specific genomic loci: biosynthetic gene clusters (BGCs). Here, we introduce plantiSMASH, a versatile online analysis platform that automates the identification of candidate plant BGCs. Moreover, it allows integration of transcriptomic data to prioritize candidate BGCs based on the coexpression patterns of predicted biosynthetic enzyme-coding genes, and facilitates comparative genomic analysis to study the evolutionary conservation of each cluster...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453568/baicalin-inhibits-biofilm-formation-attenuates-the-quorum-sensing-controlled-virulence-and-enhances-pseudomonas-aeruginosa-clearance-in-a-mouse-peritoneal-implant-infection-model
#4
Jing Luo, Biying Dong, Ke Wang, Shuangqi Cai, Tangjuan Liu, Xiaojing Cheng, Danqing Lei, Yanling Chen, Yanan Li, Jinliang Kong, Yiqiang Chen
The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa. QS-controlled biofilm formation by Pseudomonas aeruginosa in clinical settings has remained controversial due to emerging drug resistance; therefore, screening diverse compounds for anti-biofilm or anti-QS activities is important. This study demonstrates the ability of sub-minimum inhibitory concentrations (sub-MICs) of baicalin, an active natural compound extracted from the traditional Chinese medicinal Scutellaria baicalensis, to inhibit the formation of Pseudomonas aeruginosa biofilms and enhance the bactericidal effects of various conventional antibiotics in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28448135/total-synthesis-of-%C3%A2-lycojaponicumin-d-and-lycodoline-type-lycopodium-alkaloids
#5
Xian-He Zhao, Qing Zhang, Ji-Yuan Du, Xin-Yun Lu, Ye-Xing Cao, Yu-Hua Deng, Chun-An Fan
Lycopodium alkaloids with structural diversity and biological significance have been stimulating an increasing interest in synthetic and medicinal communities, in which inspiration and exploration of their related biogenetic relationship generally comprises one of the major concerns. Driven by the plausible biogenetic entry to lycojaponicumin D as the first member of Lycopodium alkaloids having structurally unusual C(3)-C(13) linked scaffold, a new connection with lycodoline has been proposed and discovered on the basis of the design of an unprecedented bioinspired tandem fragmentation/Mannich reaction...
April 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28447476/mtbvac-from-discovery-to-clinical-trials-in-tuberculosis-endemic-countries
#6
Dessislava Marinova, Jesus Gonzalo-Asensio, Nacho Aguilo, Carlos Martin
BCG remains the only vaccine against tuberculosis (TB) in use today and despite its impressive global coverage, the nature of BCG protection against the pulmonary forms of TB remains subject to ongoing debate. Because of the limitations of BCG, novel TB vaccine candidates have been developed and several have reached the clinical pipeline. One of these candidates is MTBVAC, the first and only TB vaccine in the clinical pipeline to date based on live-attenuated Mycobacterium tuberculosis that has successfully entered clinical evaluation, a historic milestone in human vaccinology...
April 27, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28447136/-environmental-health-relevance-of-airborne-microorganisms-in-ambient-and-indoor-air
#7
REVIEW
Sandra M Walser, Bernhard Brenner, Stefanie Heinze, Regine Szewzyk, Eike Wolter, Caroline E W Herr
Airborne microorganisms occur ubiquitously in the ambient air. Besides allergic and irritative-toxic effects, they can cause infections after inhalation. Occupational studies have shown that an increased incidence of respiratory diseases is found in adequately exposed workers. In addition to respiratory diseases, severe systemic infections can also occur in particular cases, such as in the case of a hantavirus infection that is recognized as an occupational disease. In studies from environmental medicine, respiratory diseases have also been observed in residents living in the vicinity of livestock facilities and evaporative cooling towers...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28447115/human-genetics-as-a-model-for-target-validation-finding-new-therapies-for-diabetes
#8
REVIEW
Soren K Thomsen, Anna L Gloyn
Type 2 diabetes is a global epidemic with major effects on healthcare expenditure and quality of life. Currently available treatments are inadequate for the prevention of comorbidities, yet progress towards new therapies remains slow. A major barrier is the insufficiency of traditional preclinical models for predicting drug efficacy and safety. Human genetics offers a complementary model to assess causal mechanisms for target validation. Genetic perturbations are 'experiments of nature' that provide a uniquely relevant window into the long-term effects of modulating specific targets...
April 26, 2017: Diabetologia
https://www.readbyqxmd.com/read/28446900/bioactive-molecule-from-streptomyces-sp-mitigates-mdr-klebsiella-pneumoniae-in-zebrafish-infection-model
#9
Lalitha Cheepurupalli, Thiagarajan Raman, Sudarshan S Rathore, Jayapradha Ramakrishnan
The emergence and spread of multi-drug resistant (MDR) especially carbapenem-resistant Klebsiella pneumoniae is a major emerging threat to public health, leading to excess in mortality rate as high as 50-86%. MDR K. pneumoniae manifests all broad mechanisms of drug resistance, hence development of new drugs to treat MDR K. pneumoniae infection has become a more relevant question in the scientific community. In the present study a potential Streptomyces sp. ASK2 was isolated from rhizosphere soil of medicinal plant...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28446524/experiences-attitudes-and-possibilities-for-improvement-concerning-the-cooperation-between-occupational-physicians-rehabilitation-physicians-and-general-practitioners-in-germany-from-the-perspectives-of-the-medical-groups-and-rehabilitation-patients-a-protocol
#10
Susanne Voelter-Mahlknecht, Jan M Stratil, Rainer Kaluscha, Gert Krischak, Monika A Rieger
INTRODUCTION: Rehabilitation measures for patients in the working age primarily aim at maintaining employability, restoring fitness for work or timely return to work (RTW). To facilitate RTW after long sick leave in Germany, both rehabilitation physicians' knowledge about the patients' workplace and communication between the rehabilitation physician and the occupational physician need to be improved. This research will record the experiences and attitudes of occupational physicians, rehabilitation physicians and general practitioners, as well as of rehabilitation patients, to indicate barriers and possibilities for improvement concerning the intersection between workplace and rehabilitation institution...
April 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28446157/natural-products-isolated-from-tetragonula-carbonaria-cerumen-modulate-free-radical-scavenging-and-5-lipoxygenase-activities-in-vitro
#11
Karina D Hamilton, Peter R Brooks, Steven M Ogbourne, Fraser D Russell
BACKGROUND: Propolis and cerumen are plant-derived products found in honeybees and stingless bees, respectively. Although propolis is an ancient folk medicine, the bioactivities of cerumen obtained from Australian native stingless bees (Tetragonula carbonaria) have not been widely studied. Therefore, we investigated selected anti-oxidant and anti-inflammatory properties of T. carbonaria cerumen. METHODS: A methanolic extract was prepared from the combined cerumen of 40 T...
April 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28445615/status-epilepticus-in-dogs-and-cats-part-1-etiopathogenesis-epidemiology-and-diagnosis
#12
Susan Blades Golubovic, John H Rossmeisl
OBJECTIVE: To review current knowledge of the etiopathogenesis, diagnosis, and consequences of status epilepticus (SE) in veterinary patients. DATA SOURCES: Human and veterinary literature, including clinical and laboratory research and reviews. ETIOPATHOGENESIS: Status epilepticus is a common emergency in dogs and cats, and may be the first manifestation of a seizure disorder. It results from the failure of termination of an isolated seizure...
April 26, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28445526/biosynthesis-of-the-oxygenated-diterpene-nezukol-in-the-medicinal-plant-isodon-rubescens-is-catalyzed-by-a-pair-of-diterpene-synthases
#13
Kyle A Pelot, David M Hagelthorn, J Bennett Addison, Philipp Zerbe
Plants produce an immense diversity of natural products (i.e. secondary or specialized metabolites) that offer a rich source of known and potentially new pharmaceuticals and other desirable bioproducts. The Traditional Chinese Medicinal plant Isodon rubescens (Lamiaceae) contains an array of bioactive labdane-related diterpenoid natural products. Of these, the ent-kauranoid oridonin is the most prominent specialized metabolite that has been extensively studied for its potent antimicrobial and anticancer efficacy...
2017: PloS One
https://www.readbyqxmd.com/read/28445049/inflammation-modulatory-phorbol-esters-from-the-seeds-of-aquilaria-malaccensis
#14
Vitthal D Wagh, Michal Korinek, I-Wen Lo, Yu-Ming Hsu, Shu-Li Chen, Hsue-Yin Hsu, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen, Yuan-Bin Cheng, Fang-Rong Chang
The tree Aquilaria malaccensis is a valuable source of agarwood, which is used in herbal medicinal preparations. Phytochemical research on A. malaccensis seeds has led to the isolation of four new phorbol esters (1-4), two known phorbol esters (5, isolated from Nature for the first time, and 6), and two known glycerides (7 and 8). The structures of these isolates were elucidated by means of spectroscopic data interpretation. The inflammation-modulatory activities of the isolates on elastase release and superoxide anion generation in human neutrophils were evaluated...
April 26, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28444967/co-delivery-of-microrna-21-antisense-oligonucleotides-and-gemcitabine-using-nanomedicine-for-pancreatic-cancer-therapy
#15
Yaqing Li, Yinting Chen, Jiajia Li, Zuoquan Zhang, Chumei Huang, Guoda Lian, Kege Yang, Shaojie Chen, Ying Lin, Lingyun Wang, Kaihong Huang, Linjuan Zeng
Tumor metastasis occurs naturally in pancreatic cancer, and the efficacy of chemotherapy is usually poor. Precision medicine, combining down-regulation of target genes with chemotherapy drugs, is expected to improve the therapeutic effects. Therefore, we developed a combined therapy of microRNA-21 antisense oligonucleotides (ASO-miR-21) and Gemcitabine (Gem) using a targeted co-delivery nanoparticle (NP) carrier and investigated the synergistic inhibitory effects on pancreatic cancer cells metastasis and growth...
April 26, 2017: Cancer Science
https://www.readbyqxmd.com/read/28444611/impact-of-collection-on-bark-regeneration-from-stryphnodendron-rotundifolium-mart-in-northeastern-brazil
#16
Ivanilda Soares Feitosa, André Sobral, Júlio Marcelino Monteiro, Elcida Lima Araújo, Ulysses Paulino Albuquerque
The growing commercial demand for products with medicinal use has caused overexploitation of several plant species worldwide. To prevent the decline of these populations, the collection of these resources should be done in a sustainable way considering the time of its replacement in natural stocks. This study was designed to identify the relationship between different intensities of extraction of bark from the trunk of Stryphnodendron rotundifolium Mart. and its regeneration speed. For this, we selected two areas of Cerrado in the Northeast of Brazil, where a monitoring experiment with duration of 24 months was performed...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28444213/representation-of-occupational-information-across-resources-and-validation-of-the-occupational-data-for-health-model
#17
Sripriya Rajamani, Elizabeth S Chen, Elizabeth Lindemann, Ranyah Aldekhyyel, Yan Wang, Genevieve B Melton
Reports by the National Academy of Medicine and leading public health organizations advocate including occupational information as part of an individual's social context. Given recent National Academy of Medicine recommendations on occupation-related data in the electronic health record, there is a critical need for improved representation. The National Institute for Occupational Safety and Health has developed an Occupational Data for Health (ODH) model, currently in draft format. This study aimed to validate the ODH model by mapping occupation-related elements from resources representing recommendations, standards, public health reports and surveys, and research measures, along with preliminary evaluation of associated value sets...
April 22, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28443130/modular-design-of-picroside-ii-biosynthesis-deciphered-through-ngs-transcriptomes-and-metabolic-intermediates-analysis-in-naturally-variant-chemotypes-of-a-medicinal-herb-picrorhiza-kurroa
#18
Varun Kumar, Ankush Bansal, Rajinder S Chauhan
Picroside-II (P-II), an iridoid glycoside, is used as an active ingredient of various commercial herbal formulations available for the treatment of liver ailments. Despite this, the knowledge of P-II biosynthesis remains scarce owing to its negligence in Picrorhiza kurroa shoots which sets constant barrier for function validation experiments. In this study, we utilized natural variation for P-II content in stolon tissues of different P. kurroa accessions and deciphered its metabolic route by integrating metabolomics of intermediates with differential NGS transcriptomes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28443025/honokiol-induces-apoptosis-g1-arrest-and-autophagy-in-kras-mutant-lung-cancer-cells
#19
Lian-Xiang Luo, Ying Li, Zhong-Qiu Liu, Xing-Xing Fan, Fu-Gang Duan, Run-Ze Li, Xiao-Jun Yao, Elaine Lai-Han Leung, Liang Liu
Aberrant signaling transduction induced by mutant KRAS proteins occurs in 20∼30% of non-small cell lung cancer (NSCLC), however, a direct and effective pharmacological inhibitor targeting KRAS has not yet reached the clinic to date. Honokiol, a small molecular polyphenol natural biophenolic compound derived from the bark of magnolia trees, exerts anticancer activity, however, its mechanism remains unknown. In this study, we sought to investigate the in vitro effects of honokiol on NSCLC cell lines harboring KRAS mutations...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28442477/nobel-laureate-a-v-hill-and-the-refugee-scholars-1933-1945
#20
Jack A Rall
A. V. Hill shared the 1922 Nobel Prize in Physiology or Medicine for his investigation of the energetics of muscular contraction. His scientific work has been well chronicled over many years (Rall JA. Mechanism of Muscular Contraction, 2014). There is the natural tendency to focus solely on an investigator's scientific achievements. But in the case of Hill, it has been said (Katz B. Biogr Mem Fellows R Soc 24: 71-149, 1978) that "it was his devotion to such wider issues, outside the boundaries of his own research, through which he exerted his most important influence on other people's lives and on the course of events...
June 1, 2017: Advances in Physiology Education
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