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https://www.readbyqxmd.com/read/28532113/nanofibers-of-human-tropoelastin-inspired-peptides-structural-characterization-and-biological-properties
#1
Valeria Secchi, Stefano Franchi, Marco Fioramonti, Giovanni Polzonetti, Giovanna Iucci, Brigida Bochicchio, Chiara Battocchio
Regenerative medicine is taking great advantage from the use of biomaterials in the treatments of a wide range of diseases and injuries. Among other biomaterials, self-assembling peptides are appealing systems due to their ability to spontaneously form nanostructured hydrogels that can be directly injected into lesions. Indeed, self-assembling peptide scaffolds are expected to behave as biomimetic matrices able to surround cells, to promote specific interactions, and to control and modify cell behavior by mimicking the native environment as well...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532071/in-vitro-antibacterial-and-cytotoxic-activities-of-plasma-modified-polyethylene-terephthalate-nonwoven-dressing-with-aqueous-extract-of-rhizome-atractylodes-macrocephala
#2
Yi-Ting Shu, Kuo-Ting Kao, Ching-Sung Weng
In this study, a natural and non-cytotoxic antibacterial dressing containing aqueous extract of Rhizome Atractylodes macrocephala (RAM), which has been widely used in traditional herbal medicine and documented with antibacterial activities in literatures, was developed by aid of the extraction technique, nonwoven substrates and plasma-induced grafting technology. The effectiveness of these herbal antibacterial dressings with different treatment were investigated through the assays of grafting yield, SEM, FTIR, antibacterial activities and cytotoxicity...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531126/the-impact-of-halloysite-on-the-thermo-mechanical-properties-of-polymer-composites
#3
REVIEW
Tayser Sumer Gaaz, Abu Bakar Sulong, Abdul Amir H Kadhum, Ahmed A Al-Amiery, Mohamed H Nassir, Ahed Hameed Jaaz
Nanotubular clay minerals, composed of aluminosilicate naturally structured in layers known as halloysite nanotubes (HNTs), have a significant reinforcing impact on polymer matrixes. HNTs have broad applications in biomedical applications, the medicine sector, implant alloys with corrosion protection and manipulated transportation of medicines. In polymer engineering, different research studies utilize HNTs that exhibit a beneficial enhancement in the properties of polymer-based nanocomposites. The dispersion of HNTs is improved as a result of pre-treating HNTs with acids...
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28529919/the-role-of-nutraceuticals-in-the-prevention-of-cardiovascular-disease
#4
REVIEW
Bozena Sosnowska, Peter Penson, Maciej Banach
Cardiovascular disease (CVD) ranks among the most common health-related and economic issues worldwide. Dietary factors are important contributors to cardiovascular risk, either directly, or through their effects on other cardiovascular risk factors including hypertension, dyslipidemia and diabetes mellitus. Nutraceuticals are natural nutritional compounds, which have been shown to be efficacious in preventative medicine or in the treatment of disease. Several foods and dietary supplements have been shown to protect against the development of CVD...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28529910/generalizable-items-of-quantitative-and-qualitative-cornerstones-for-personnel-requirement-of-physicians-in-anesthesia
#5
REVIEW
Manfred Weiss, Rolf Rossaint, Thomas Iber
Anesthesiologists perform a broad spectrum of tasks. However, in many countries, there is no legal basis for personnel staffing of physicians in anesthesia. Also, the German diagnosis related groups system for refunding does not deliver such a basis. Thus, in 2006 a new calculation base for the personnel requirement that included an Excel calculation sheet was introduced by the German Board of Anesthesiologists (BDA) and the German Society of Anesthesiology and Intensive Care Medicine (DGAI), and updated in 2009 and 2015...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28529644/3-3-diindolylmethane-stimulates-exosomal-wnt11-autocrine-signaling-in-human-umbilical-cord-mesenchymal-stem-cells-to-enhance-wound-healing
#6
Hui Shi, Xiao Xu, Bin Zhang, Jiahao Xu, Zhaoji Pan, Aihua Gong, Xu Zhang, Rong Li, Yaoxiang Sun, Yongmin Yan, Fei Mao, Hui Qian, Wenrong Xu
Human umbilical cord-derived mesenchymal stem cells (hucMSCs) are suggested as a promising therapeutic tool in regenerative medicine, however, their efficacy requires improvement. Small molecules and drugs come up to be a convenient strategy in regulating stem cells fate and function. Here, we evaluated 3,3'-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model. HucMSCs primed with 50 μM of DIM exhibited desirable repairing effects compared with untreated hucMSCs...
2017: Theranostics
https://www.readbyqxmd.com/read/28529304/sebastian-kneipp-and-the-natural-cure-movement-of-germany-between-naturalism-and-modern-medicine
#7
Youkyung Ko
This study discusses the historical significance of the Natural Cure Movement of Germany, centering on the Kneipp Cure, a form of hydrotherapy practiced by Father Sebastian Kneipp (1821-1897). The Kneipp Cure rested on five main tenets: hydrotherapy, exercise, nutrition, herbalism, and the balance of mind and body. This study illuminates the reception of the Kneipp Cure in the context of the trilateral relationship among the Kneipp Cure, the Natural Cure Movement in general, and modern medicine. The Natural Cure Movement was ideologically based on naturalism, criticizing industrialization and urbanization...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28528955/potential-therapeutic-activity-of-phlogacanthus-thyrsiformis-hardow-mabb-flower-extract-and-its-biofabricated-silver-nanoparticles-against-chemically-induced-urolithiasis-in-male-wistar-rats
#8
Poppy Das, Kiran Kumar, Arunai Nambiraj, Reshma Rajan, Rajendra Awasthi, Kamal Dua, Himaja M
Urolithiasis is a painful disorder in which stones are formed in the kidney, bladder or urethra. There are no proper therapeutic treatments available for kidney stones and people suffering from larger stones have to undergo surgery which has many side effects. A natural remedy with therapeutic effects that can dissipate and remove even the larger stones would eliminate the need of a surgery and the risks associated with it. The flowers of Phlogacanthus thyrsiformis used in culinary recipes in the north eastern India are also widely used as a folklore medicine for the treatment of kidney stones and liver disorders...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28528952/an-overview-of-natural-renewable-bio-polymer-lignin-towards-nano-and-biotechnological-applications
#9
REVIEW
Selvaraj Mohana Roopan
Lignin were said to be major bio-polymer next to cellulose which is an abundant biopolymer. This type of lignin was mostly isolated from woods which were named after their physical, morphological appearances and majorly on extracting sources. Still now there are very few reports on isolation, identification of pure lignin and isolating pathways are also not well defined. Molecular weight of lignin varies from thousands to ten thousands which are not explored accurately. Even-though lignins were surrounded by these many hurdles it has various application studies which were studied and reported...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28527898/triterpenes-and-meroterpenes-from-ganoderma-lucidum-with-inhibitory-activity-against-hmgs-reductase-aldose-reductase-and-%C3%AE-glucosidase
#10
Baosong Chen, Jin Tian, Jinjin Zhang, Kai Wang, Li Liu, Bo Yang, Li Bao, Hongwei Liu
Seven new compounds including four lanostane triterpenoids, lucidenic acids Q-S (1-3) and methyl ganoderate P (4), and three triterpene-farnesyl hydroquinone conjugates, ganolucinins A-C (5-7), one new natural product ganomycin J (8), and 73 known compounds (9-81) were isolated from fruiting bodies of Ganoderma lucidum. The structures of the compounds 1-8 were determined by spectroscopic methods. Bioactivities of compounds isolated were assayed against HMG-CoA reductase, aldose reductase, α-glucosidase, and PTP1B...
May 17, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28527183/analytical-methods-in-tracing-honey-authenticity
#11
Jelena Trifković, Filip Andrić, Petar Ristivojević, Etil Guzelmeric, Erdem Yesilada
Honey is a precious natural product that is marketed with a wide range of nutritional and medicinal properties. However, it is also a product subjected to frequent adulteration through mislabeling and mixing with cheaper and lower-quality honeys and various sugar syrups. In that sense, honey authentication regarding its genuine botanical and geographical origins, as well as the detection of any adulteration, is essential in order to protect consumer health and to avoid competition that could create a destabilized market...
May 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28526928/exosomes-in-cardiovascular-medicine
#12
REVIEW
Iain M Dykes
Exosomes are small, extracellular membrane-bound particles that mediate intercellular transport of a cytosolic cargo. Exosomal transfer of micro-RNA can modify gene expression in targeted cells. Exosome-based endocrine/paracrine signaling has been shown to be involved in a wide range of physiological processes including those associated with cardiovascular injury and disease, but remains relatively poorly understood. Exosomes offer great potential to the clinical field, with applications in both diagnostics and therapeutics...
May 19, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28526628/heparin-based-hydrogels-induce-human-renal-tubulogenesis-in-vitro
#13
Heather M Weber, Mikhail V Tsurkan, Valentina Magno, Uwe Freudenberg, Carsten Werner
Dialysis or kidney transplantation is the only therapeutic option for end stage renal disease. Accordingly, there is a large unmet clinical need for new causative therapeutic treatments. Obtaining robust models that mimic the complex nature of the human kidney is a critical step in the development of new therapeutic strategies. Here we establish a synthetic in vitro human renal tubulogenesis model based on a tunable glycosaminoglycan-hydrogel platform. In this system, renal tubulogenesis can be modulated by the adjustment of hydrogel mechanics and degradability, growth factor signaling, and the presence of insoluble adhesion cues, potentially providing new insights for regenerative therapy...
May 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28526570/role-of-medicinal-plants-on-growth-performance-and-immune-status-in-fish
#14
REVIEW
Elham Awad, Amani Awaad
Disease outbreaks increase proportionally with increases in intensive aquaculture. Natural products including medicinal plants have been known from thousands of years for treating some human diseases. It is well known that many active compounds are responsible for potential bio-activities. For that reason, there has been considerable interest in the use of medicinal plants in aquaculture with a view to providing safe and eco-friendly compounds for replacing antibiotics and chemical compounds as well as to enhance immune status and control fish diseases...
May 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28524381/antifungal-activity-of-gallic-acid-in-vitro-and-in-vivo
#15
Zhi-Jian Li, Meng Liu, Gulina Dawuti, Qin Dou, Yu Ma, Heng-Ge Liu, Silafu Aibai
Gallic acid (GA) is a polyphenol natural compound found in many medicinal plant species, including pomegranate rind (Punica granatum L.), and has been shown to have antiinflammatory and antibacterial properties. Pomegranate rind is used to treat bacterial and fungal pathogens in Uyghur and other systems of traditional medicine, but, surprisingly, the effects of GA on antifungal activity have not yet been reported. In this study, we aimed to investigate the inhibitory effects of GA on fungal strains both in vitro and in vivo...
May 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28523637/the-invention-of-artificial-fertilization-in-the-eighteenth-and-nineteenth-century
#16
Barbara Orland
Artificial insemination and other fertilization techniques are today considered central to the history of reproductive medicine. The medical treatment of infertile couples, however, constitutes just a small part of the whole story of artificial fertilization. Lazzaro Spallanzani (1729-1799) in particular, said to have been the inventor of artificial insemination, did not develop this method for medical purposes. He belonged to a generation of naturalists to whom artificial insemination was part of a heterogeneous series of investigations that were undertaken to explore the natural history of animal generation...
June 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28522885/dynamically-tunable-cell-culture-platforms-for-tissue-engineering-and-mechanobiology
#17
Koichiro Uto, Jonathan H Tsui, Cole A DeForest, Deok-Ho Kim
Human tissues are sophisticated ensembles of many distinct cell types embedded in the complex, but well-defined, structures of the extracellular matrix (ECM). Dynamic biochemical, physicochemical, and mechano-structural changes in the ECM define and regulate tissue-specific cell behaviors. To recapitulate this complex environment in vitro, dynamic polymer-based biomaterials have emerged as powerful tools to probe and direct active changes in cell function. The rapid evolution of polymerization chemistries, structural modulation, and processing technologies, as well as the incorporation of stimuli-responsiveness, now permit synthetic microenvironments to capture much of the dynamic complexity of native tissue...
February 2017: Progress in Polymer Science
https://www.readbyqxmd.com/read/28522743/forward-to-the-past-the-case-for-quantitative-pet-imaging
#18
Adriaan A Lammertsma
Positron emission tomography (PET) was developed in the 1970's as an in vivo method to measure regional pathophysiological processes. In the 1990's the focus moved to the detection of local increases in uptake, first in the brain (activation studies) and later in oncology (finding metastases), where (18)F-FDG emerged as a highly sensitive staging technique. This focus on sensitivity has overshadowed the other main characteristic of PET, its quantitative nature. In recent years there has been a new shift. PET is now seen as a promising tool for drug development and precision medicine, i...
May 18, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28521790/unintentional-drowning-role-of-medicinal-drugs-and-alcohol
#19
Tuulia Pajunen, Erkki Vuori, Frank F Vincenzi, Pirjo Lillsunde, Gordon Smith, Philippe Lunetta
BACKGROUND: Alcohol is a well-known risk factor in unintentional drownings. Whereas psychotropic drugs, like alcohol, may cause psychomotor impairment and affect cognition, no detailed studies have focused on their association with drowning. Finland provides extensive post-mortem toxicological data for studies on drowning because of its high medico-legal autopsy rates. METHODS: Drowning cases, 2000 through 2009, for which post-mortem toxicological analysis was performed, came from the database of the Toxicological Laboratory, Department of Forensic Medicine, University of Helsinki, using the ICD-10 nature-of-injury code T75...
May 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28521374/phytochemistry-and-pharmacology-of-ferula-hermonis-boiss-a-review
#20
Zohreh Sattar, Mehrdad Iranshahi
Ferula hermonis, a well-known species of the genus Ferula found in Lebanon and Syria, has a brilliant history in traditional medicine as it has been used for the treatment of erectile dysfunction in men and menopausal disturbances in women. Thanks to modern pharmacological and clinical investigations, F. hermonis is a valuable medicinal and condimental plant that may be used for the treatment of impotence and diabetes, the prevention of osteoporosis, and possesses anti-microbial and anti-inflammatory properties...
May 18, 2017: Drug Research
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