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Nature neuroscience

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https://www.readbyqxmd.com/read/28094464/test-retest-reliability-of-functional-connectivity-networks-during-naturalistic-fmri-paradigms
#1
Jiahui Wang, Yudan Ren, Xintao Hu, Vinh Thai Nguyen, Lei Guo, Junwei Han, Christine Cong Guo
Functional connectivity analysis has become a powerful tool for probing the human brain function and its breakdown in neuropsychiatry disorders. So far, most studies adopted resting-state paradigm to examine functional connectivity networks in the brain, thanks to its low demand and high tolerance that are essential for clinical studies. However, the test-retest reliability of resting-state connectivity measures is moderate, potentially due to its low behavioral constraint. On the other hand, naturalistic neuroimaging paradigms, an emerging approach for cognitive neuroscience with high ecological validity, could potentially improve the reliability of functional connectivity measures...
January 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28093304/chloride-conducting-light-activated-channel-gtacr2-can-produce-both-cessation-of-firing-and-generation-of-action-potentials-in-cortical-neurons-in-response-to-light
#2
A Y Malyshev, M V Roshchin, G R Smirnova, D A Dolgikh, P M Balaban, M A Ostrovsky
Optogenetics is a powerful technique in neuroscience that provided a great success in studying the brain functions during the last decade. Progress of optogenetics crucially depends on development of new molecular tools. Light-activated cation-conducting channelrhodopsin2 was widely used for excitation of cells since the emergence of optogenetics. In 2015 a family of natural light activated chloride channels GtACR was identified which appeared to be a very promising tool for using in optogenetics experiments as a cell silencer...
January 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28088350/the-emotive-nature-of-conflict-monitoring-in-the-medial-prefrontal-cortex
#3
Blair Saunders, Hause Lin, Marina Milyavskaya, Michael Inzlicht
The detection of conflict between incompatible impulses, thoughts, and actions is a ubiquitous source of motivation across theories of goal-directed action. In this overview, we explore the hypothesis that conflict is emotive, integrating perspectives from affective science and cognitive neuroscience. Initially, we review evidence suggesting that the mental and biological processes that monitor for information processing conflict-particularly those generated by the anterior midcingulate cortex-track the affective significance of conflict and use this signal to motivate increased control...
January 11, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28059117/non-invasive-focused-ultrasound-facilitated-gene-delivery-for-optogenetics
#4
Shutao Wang, Tara Kugelman, Amanda Buch, Mathieu Herman, Yang Han, Maria Eleni Karakatsani, S Abid Hussaini, Karen Duff, Elisa E Konofagou
Optogenetics, a widely used technique in neuroscience research, is often limited by its invasive nature of application. Here, we present a noninvasive, ultrasound-based technique to introduce optogenetic channels into the brain by temporarily opening the blood-brain barrier (BBB). We demonstrate the efficiency of the method developed and evaluate the bioactivity of the non-invasively introduced channelrhodopsin channels by performing stimulation in freely behaving mice.
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28055036/preparation-and-implementation-of-optofluidic-neural-probes-for-in-vivo-wireless-pharmacology-and-optogenetics
#5
Jordan G McCall, Raza Qazi, Gunchul Shin, Shuo Li, Muhammad Hamza Ikram, Kyung-In Jang, Yuhao Liu, Ream Al-Hasani, Michael R Bruchas, Jae-Woong Jeong, John A Rogers
This Protocol Extension describes the fabrication and technical procedures for implementing ultrathin, flexible optofluidic neural probe systems that provide targeted, wireless delivery of fluids and light into the brains of awake, freely behaving animals. As a Protocol Extension article, this article describes an adaptation of an existing Protocol that offers additional applications. This protocol serves as an extension of an existing Nature Protocol describing optoelectronic devices for studying intact neural systems...
February 2017: Nature Protocols
https://www.readbyqxmd.com/read/28044019/resolving-the-neural-dynamics-of-visual-and-auditory-scene-processing-in-the-human-brain-a-methodological-approach
#6
REVIEW
Radoslaw Martin Cichy, Santani Teng
In natural environments, visual and auditory stimulation elicit responses across a large set of brain regions in a fraction of a second, yielding representations of the multimodal scene and its properties. The rapid and complex neural dynamics underlying visual and auditory information processing pose major challenges to human cognitive neuroscience. Brain signals measured non-invasively are inherently noisy, the format of neural representations is unknown, and transformations between representations are complex and often nonlinear...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28033550/alignment-in-social-interactions
#7
M Gallotti, M T Fairhurst, C D Frith
According to the prevailing paradigm in social-cognitive neuroscience, the mental states of individuals become shared when they adapt to each other in the pursuit of a shared goal. We challenge this view by proposing an alternative approach to the cognitive foundations of social interactions. The central claim of this paper is that social cognition concerns the graded and dynamic process of alignment of individual minds, even in the absence of a shared goal. When individuals reciprocally exchange information about each other's minds processes of alignment unfold over time and across space, creating a social interaction...
December 26, 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/28030362/the-guilty-brain-the-utility-of-neuroimaging-and-neurostimulation-studies-in-forensic-field
#8
Francesca Mameli, Cristina Scarpazza, Emanuele Tomasini, Roberta Ferrucci, Fabiana Ruggiero, Giuseppe Sartori, Alberto Priori
Several studies have aimed to address the natural inability of humankind to detect deception and accurately discriminate lying from truth in the legal context. To date, it has been well established that telling a lie is a complex mental activity. During deception, many functions of higher cognition are involved: the decision to lie, withholding the truth, fabricating the lie, monitoring whether the receiver believes the lie, and, if necessary, adjusting the fabricated story and maintaining a consistent lie...
December 28, 2016: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28029630/design-of-a-closed-loop-bidirectional-brain-machine-interface-system-with-energy-efficient-neural-feature-extraction-and-pid-control
#9
Xilin Liu, Milin Zhang, Andrew G Richardson, Timothy H Lucas, Jan Van der Spiegel
This paper presents a bidirectional brain machine interface (BMI) microsystem designed for closed-loop neuroscience research, especially experiments in freely behaving animals. The system-on-chip (SoC) consists of 16-channel neural recording front-ends, neural feature extraction units, 16-channel programmable neural stimulator back-ends, in-channel programmable closed-loop controllers, global analog-digital converters (ADC), and peripheral circuits. The proposed neural feature extraction units includes 1) an ultra low-power neural energy extraction unit enabling a 64-step natural logarithmic domain frequency tuning, and 2) a current-mode action potential (AP) detection unit with time-amplitude window discriminator...
December 16, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28027954/simulating-social-interactions-for-the-experimental-investigation-of-joint-attention
#10
REVIEW
Nathan Caruana, Genevieve McArthur, Alexandra Woolgar, Jon Brock
Social interactions are, by their nature, dynamic and reciprocal - your behaviour affects my behaviour, which affects your behaviour in return. However, until recently, the field of social cognitive neuroscience has been dominated by paradigms in which participants passively observe social stimuli from a detached "third person" perspective. Here we consider the unique conceptual and methodological challenges involved in adopting a "second person" approach whereby social cognitive mechanisms and their neural correlates are investigated within social interactions (Schilbach et al...
December 24, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28026746/robust-estimation-of-sparse-narrowband-spectra-from-binary-neuronal-spiking-data
#11
Sina Miran, Patrick Purdon, Emery Brown, Behtash Babadi
OBJECTIVE: Characterizing the spectral properties of neuronal responses is an important problem in computational neuroscience, as it provides insight into the spectral organization of the underlying functional neural processes. Although spectral analysis techniques are widely used in the analysis of noninvasive neural recordings such as EEG, their application to spiking data is limited due to the binary and non-linear nature of neuronal spiking. In this paper, we address the problem of estimating the power spectral density of the neural covariate driving the spiking statistics of a neuronal population from binary observations...
December 22, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28017150/nanotechnology-in-neuroscience-and-its-perspective-as-gene-carrier
#12
T M T Khan, D Wei, P H L Tran, T D T Thao
Gene therapy has a strong potential in neuroscience by suppressing or replacing abnormalities in genetic materials. The employment of nano-gene carrier for neurological disorders is comparatively young and restricted since the aim to effectively deliver therapeutic agents into the central nervous system (CNS) commonly has confronted difficulties of several natural occurring barriers in the body and unfavorable characteristics of pharmaceutical agents. Two major anatomical and biochemical barriers are blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), which significantly prevent permeation of most drugs and genes to brain parenchyma...
December 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28001035/serotonin-in-space-understanding-single-fibers
#13
Skirmantas Janušonis
All brain regions contain fibers that store and release 5-hydroxytryptamine (5-HT, serotonin). Since these fibers often do not have well-defined trajectories, most studies have focused on their overall densities, a measure that can be associated with local 5-HT tone in heathy and diseased brains. However, the observed fiber densities are the consequence of the behavior of single fibers. Evidence is presented as to why understanding single-fiber trajectories is important for basic and clinical neuroscience. In particular, serotonergic fibers can be viewed as natural, readily detectable stochastic probes that sample the invisible microarchitecture of brain tissue...
December 21, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27994147/ownership-of-an-artificial-limb-induced-by-electrical-brain-stimulation
#14
Kelly L Collins, Arvid Guterstam, Jeneva Cronin, Jared D Olson, H Henrik Ehrsson, Jeffrey G Ojemann
Replacing the function of a missing or paralyzed limb with a prosthetic device that acts and feels like one's own limb is a major goal in applied neuroscience. Recent studies in nonhuman primates have shown that motor control and sensory feedback can be achieved by connecting sensors in a robotic arm to electrodes implanted in the brain. However, it remains unknown whether electrical brain stimulation can be used to create a sense of ownership of an artificial limb. In this study on two human subjects, we show that ownership of an artificial hand can be induced via the electrical stimulation of the hand section of the somatosensory (SI) cortex in synchrony with touches applied to a rubber hand...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27990213/a-hybrid-microfluidic-device-for-on-demand-orientation-and-multidirectional-imaging-of-c-elegans-organs-and-neurons
#15
Ramtin Ardeshiri, Ben Mulcahy, Mei Zhen, Pouya Rezai
C. elegans is a well-known model organism in biology and neuroscience with a simple cellular (959 cells) and nervous (302 neurons) system and a relatively homologous (40%) genome to humans. Lateral and longitudinal manipulation of C. elegans to a favorable orientation is important in many applications such as neural and cellular imaging, laser ablation, microinjection, and electrophysiology. In this paper, we describe a micro-electro-fluidic device for on-demand manipulation of C. elegans and demonstrate its application in imaging of organs and neurons that cannot be visualized efficiently under natural orientation...
November 2016: Biomicrofluidics
https://www.readbyqxmd.com/read/27965557/the-multivariate-temporal-response-function-mtrf-toolbox-a-matlab-toolbox-for-relating-neural-signals-to-continuous-stimuli
#16
Michael J Crosse, Giovanni M Di Liberto, Adam Bednar, Edmund C Lalor
Understanding how brains process sensory signals in natural environments is one of the key goals of twenty-first century neuroscience. While brain imaging and invasive electrophysiology will play key roles in this endeavor, there is also an important role to be played by noninvasive, macroscopic techniques with high temporal resolution such as electro- and magnetoencephalography. But challenges exist in determining how best to analyze such complex, time-varying neural responses to complex, time-varying and multivariate natural sensory stimuli...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27965548/methodological-problems-on-the-way-to-integrative-human-neuroscience
#17
REVIEW
Boris Kotchoubey, Felix Tretter, Hans A Braun, Thomas Buchheim, Andreas Draguhn, Thomas Fuchs, Felix Hasler, Heiner Hastedt, Thilo Hinterberger, Georg Northoff, Ingo Rentschler, Stephan Schleim, Stephan Sellmaier, Ludger Tebartz Van Elst, Wolfgang Tschacher
Neuroscience is a multidisciplinary effort to understand the structures and functions of the brain and brain-mind relations. This effort results in an increasing amount of data, generated by sophisticated technologies. However, these data enhance our descriptive knowledge, rather than improve our understanding of brain functions. This is caused by methodological gaps both within and between subdisciplines constituting neuroscience, and the atomistic approach that limits the study of macro- and mesoscopic issues...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27940318/individual-differences-in-affective-neuroscience-personality-scale-anps-primary-emotional-traits-and-depressive-tendencies
#18
Christian Montag, Katharina Widenhorn-Müller, Jaak Panksepp, Markus Kiefer
BACKGROUND: The present study investigated individual differences in the Affective Neuroscience Personality Scales (ANPS), representing measures of primary emotional systems, and depressive tendencies in two independent samples. METHODS: In order to be able to find support for a continuum model with respect to the relation of strength in the cross-species "affective neuroscience" taxonomy of primary emotional systems, we investigated ANPS measured personality traits in a psychologically mostly healthy population (n=614 participants) as well as a sample of clinically depressed people (n=55 depressed patients)...
November 18, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27921311/the-neurobiology-of-parenting-a-neural-circuit-perspective
#19
Johannes Kohl, Anita E Autry, Catherine Dulac
Social interactions are essential for animals to reproduce, defend their territory, and raise their young. The conserved nature of social behaviors across animal species suggests that the neural pathways underlying the motivation for, and the execution of, specific social responses are also maintained. Modern tools of neuroscience have offered new opportunities for dissecting the molecular and neural mechanisms controlling specific social responses. We will review here recent insights into the neural circuits underlying a particularly fascinating and important form of social interaction, that of parental care...
January 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27918065/a-statistical-proposal-for-selecting-a-data-depending-threshold-in-neurobiology
#20
P Finotelli, F Panzica, P Dulio, F Rotondi, G Varotto
In this paper we propose a new methodology for introducing thresholds in the analysis of neuro- biological databases. Often, in Neuroscience, absolute thresholds are adopted. This is done by cutting the data below (or above) predetermined values of the involved parameters, without an analysis of the distribution of the collected data concerning the phenomenon under investigation. Despite an absolute threshold could be rigorously defined in terms of physic parameters, it can be influenced by many different subjective aspects, including cognitive processes, and individual adaptation to the external stimuli...
June 1, 2016: Archives Italiennes de Biologie
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