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https://www.readbyqxmd.com/read/28822049/potential-for-diagnosis-versus-therapy-monitoring-of-attention-deficit-hyperactivity-disorder-a-new-epigenetic-biomarker-interacting-with-both-genotype-and-auto-immunity
#1
Walter Adriani, Emilia Romano, Mariangela Pucci, Esterina Pascale, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Paolo Curatolo, Oleg Granstrem, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addario
In view of the need for easily accessible biomarkers, we evaluated in ADHD children the epigenetic status of the 5'-untranslated region (UTR) in the SLC6A3 gene, coding for human dopamine transporter (DAT). We analysed buccal swabs and sera from 30 children who met DSM-IV-TR criteria for ADHD, assigned to treatment according to severity. Methylation levels at six-selected CpG sites (among which, a CGGCGGCGG and a CGCG motif), alone or in combination with serum titers in auto-antibodies against dopamine transporter (DAT aAbs), were analysed for correlation with CGAS scores (by clinicians) and Conners' scales (by parents), collected at recruitment and after 6 weeks...
August 18, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28818147/attention-deficit-hyperactivity-disorder-and-fatal-accidents-in-aviation-medicine
#2
Tanja Laukkala, Robert Bor, Bruce Budowle, Antti Sajantila, Pooshan Navathe, Markku Sainio, Alpo Vuorio
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with symptoms of inattention and/or hyperactivity-impulsivity that interfere with functioning and/or development. ADHD occurs in about 2.5% of adults. ADHD can be an excluding medical condition among pilots due to the risk of attentional degradation and therefore impact on flight safety. Diagnosis of ADHD is complex, which complicates aeromedical assessment. This study highlights fatal accident cases among pilots with ADHD and discusses protocols to detect its presence to help to assess its importance to flight safety...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28812318/the-development-and-flexibility-of-gaze-alternations-in-bonobos-and-chimpanzees
#3
Kelsey Lucca, Evan L MacLean, Brian Hare
Infants' early gaze alternations are one of their first steps towards a sophisticated understanding of the social world. This ability, to gaze alternate between an object of interest and another individual also attending to that object, has been considered foundational to the development of many complex social-cognitive abilities, such as theory of mind and language. However, to understand the evolution of these abilities, it is important to identify whether and how gaze alternations are used and develop in our closest living relatives, bonobos (Pan paniscus) and chimpanzees (Pan troglodytes)...
August 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28808832/factor-structure-of-teacher-ratings-of-the-odd-symptoms-in-children
#4
Rapson Gomez, Vasileios Stavropoulos, George Van Doorn
This study used confirmatory factor analysis (CFA) to determine the best model for Oppositional Defiant Disorder (ODD) symptoms in children aged 3 to 15 years, as presented in the Disruptive Behavior Rating Scale. Teachers' ratings of the ODD symptoms of 213 children from general community schools in Australia were obtained. The findings provided most support for a bifactor model based on Stringaris and Goodman's [1] three-factor model (primary factors for irritable, hurtful, and headstrong). The general factor, but not the group factors in the model, showed high omega hierarchical and explained common variance...
August 15, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28803458/neglect-and-aphasia-in-the-acute-phase-as-predictors-of-functional-outcome-seven-years-after-ischemic-stroke
#5
Joel Gerafi, Hans Samuelsson, Jo I Viken, Charlotte Blomgren, Lisbeth Claesson, Sakari Kallio, Christina Jern, Christian Blomstrand, Katarina Jood
BACKGROUND: Visuospatial inattention (VSI) and language impairment (LI) are often present early after stroke and associations with an unfavorable short-term functional outcome have been reported. The purpose of this study was to investigate if a screening of VSI and of LI as indicators of cortical symptoms early after stroke could predict long-term functional outcomes. METHODS: A consecutive cohort of 375 ischemic stroke patients was assessed for the occurrence of VSI, in median, 7 days after admission (interquartile range 5 days) using Star Cancellation Test (SCT) and for LI (within the first 7 days) with the language item in the Scandinavian Stroke Scale (SSS)...
August 12, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28802148/inattentional-blindness-in-anesthesiology-a-simulation-study
#6
Anthony M-H Ho, Joseph Y C Leung, Glenio B Mizubuti, Leeanne H Contardi, Matthew T V Chan, Thomas S F Lo, Alex K T Lee
STUDY OBJECTIVES: Inattentional blindness is the psychological phenomenon of inability to see the unexpected even if it is in plain view. We hypothesized that anesthesiologists may overlook unexpected intraoperative events whereas medical students, lacking in intraoperative monitoring experience and knowledge, may be more likely to notice such events. DESIGN: A simulation study using a video of a simulated septic patient undergoing abdominal surgery. SETTING: A large academic center...
August 9, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28800716/co-occurrence-of-asd-and-adhd-traits-in-an-adult-population
#7
Maria Panagiotidi, Paul G Overton, Tom Stafford
OBJECTIVE: ADHD and autism spectrum disorder (ASD) can be viewed as the extreme end of traits found in the general population. Clinical and genetic studies suggest that ADHD and ASD often co-occur and share genetic susceptibility. The aim of this study was to examine co-occurrence of ADHD and ASD traits in the general population. METHOD: In total, 334 participants were recruited from a population-based sample. Four questionnaires assessing current and retrospective ADHD and ASD traits were administered online: the Adult ADHD Self-Report Scale (ASRS) Symptom Checklist, the Wender Utah Rating Scale (WURS-25), the Broad Autism Phenotype Questionnaire (BAPQ), and the Autism Spectrum Quotient (AQ)...
August 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28799448/association-of-adhd-and-executive-functioning-with-childhood-depression
#8
Michelle C Fenesy, Steve S Lee
OBJECTIVE: Despite its association with increased severity and treatment resistance, relatively little is known about the correlates of early-onset childhood depression. ADHD and executive functioning (EF) are each related to depression. Given their covariation, we tested the independent association of ADHD dimensions (i.e., inattention, hyperactivity) and EF with childhood depression using structural equation modeling to identify potential targets for intervention. METHOD: Participants were 225 five- to 10-year-old children (68% male) with ( n = 117) and without ( n = 108) ADHD...
August 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28791531/processing-speed-predicts-behavioral-treatment-outcomes-in-children-with-attention-deficit-hyperactivity-disorder-predominantly-inattentive-type
#9
Christopher J Adalio, Elizabeth B Owens, Keith McBurnett, Stephen P Hinshaw, Linda J Pfiffner
Neuropsychological functioning underlies behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD). Children with all forms of ADHD are vulnerable to working memory deficits and children presenting with the inattentive form of ADHD (ADHD-I) appear particularly vulnerable to processing speed deficits. As ADHD-I is the most common form of ADHD presented by children in community settings, it is important to consider how treatment interventions for children with ADHD-I may be affected by deficits in processing speed and working memory...
August 9, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28783930/the-relationship-between-the-snap-25-polymorphism-and-omission-errors-in-korean-children-with-attention-deficit-hyperactivity-disorder
#10
Eunjoo Kim, Dong-Ho Song, Nam-Wook Kim, In-Jung Sohn, Keun-Ah Cheon
Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28777180/sleep-wake-disorders-of-childhood
#11
Suresh Kotagal
PURPOSE OF REVIEW: Sleep-wake disorders occur in 10% to 28% of children and differ somewhat in pathophysiology and management from sleep-wake disorders in adults. This article discusses the diagnosis and management of key childhood sleep disorders. RECENT FINDINGS: The role of sleep in memory consolidation and in the facilitation of learning has been increasingly recognized, even at the toddler stage. Cataplexy, a key feature of narcolepsy type 1, may be subtle in childhood and characterized by transient muscle weakness isolated to the face...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28774371/-effect-of-baicalin-on-behavioral-characteristics-of-rats-with-attention-deficit-hyperactivity-disorder
#12
Rong-Yi Zhou, Xin-Min Han, Jiao-Jiao Wang, Hai-Xia Yuan, Ji-Chao Sun, Yue You, Yu-Chen Song
OBJECTIVE: To investigate the effect of baicalin on the behavioral characteristics of rats with attention deficit hyperactivity disorder (ADHD), and to provide a basis for further research on baicalin in the treatment of ADHD. METHODS: A total of 40 SHR rats were randomly divided into model group, methylphenidate hydrochloride (MPH) group, and low-, medium-, and high-dose baicalin groups, with 8 rats in each group. Eight WKY rats were selected as normal control group...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28771088/behavioral-effects-of-a-locomotor-based-physical-activity-intervention-on-preschoolers
#13
Sarah Anne Burkart, Jasmin Roberts, Matthew Davidson, Sofiya Alhassan
BACKGROUND: Poor adaptive learning behaviors (i.e. distractibility, inattention, disruption) are associated with behavior problems and underachievement in school, as well as indicating potential attention deficit hyperactivity disorder (ADHD). Strategies are needed to limit these behaviors. Physical activity (PA) has been suggested to improve behavior in school-age children, but little is known about this relationship in preschoolers. This study examined the effects of a PA intervention on classroom behaviors in preschool-aged children...
August 3, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28768738/altered-tactile-sensitivity-in-children-with-attention-deficit-hyperactive-disorder
#14
Nicolaas A J Puts, Ashley D Harris, Mark Mikkelsen, Mark Tommerdahl, Richard Ae Edden, Stewart H Mostofsky
ADHD is characterized by an inability to concentrate, heightened activity, and hypermotoric behavior, but sensory, e.g. tactile, problems are common. The literature on tactile impairments in ADHD is limited, with most work employing clinical observations or questionnaires. Here, we study tactile processing in children with ADHD, and hypothesize that children with ADHD show reduced performance in tasks closely linked to inhibition. Sixty seven children with ADHD and 62 typically developing children performed a battery of tasks grouped in domains: simple and choice reaction time; static and dynamic detection threshold (probing feed-forward inhibition); amplitude discrimination without adaptation, and with dual, and single-site adaptation (probing lateral inhibition and adaptation); sequential and simultaneous frequency discrimination (previously linked to GABA); and temporal order judgment with and without a synchronous carrier stimulus...
August 2, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28763482/attention-impairments-and-adhd-symptoms-in-adult-narcoleptic-patients-with-and-without-hypocretin-deficiency
#15
Marco Filardi, Fabio Pizza, Lorenzo Tonetti, Elena Antelmi, Vincenzo Natale, Giuseppe Plazzi
BACKGROUND: Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results. We aimed to assess the impact of hypocretin deficiency on attentional functioning by comparing performances on the attention network test (ANT) of narcoleptic patients with hypocretin deficiency (narcolepsy type 1-NT1) versus patients without hypocretin deficiency (narcolepsy type 2-NT2) and healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28754891/cyclin-dependent-kinase-5-novel-role-of-gene-variants-identified-in-adhd
#16
Subhamita Maitra, Mahasweta Chatterjee, Swagata Sinha, Kanchan Mukhopadhyay
Cortical neuronal migration and formation of filamentous actin cytoskeleton, needed for development, normal cell growth and differentiation, are regulated by the cyclin-dependent kinase 5 (Cdk5). Attention deficit hyperactivity disorder (ADHD) is associated with delayed maturation of the brain and hence we hypothesized that cdk5 may have a role in ADHD. Eight functional CDK5 gene variants were analyzed in 848 Indo-Caucasoid individuals including 217 families with ADHD probands and 250 healthy volunteers. Only three variants, rs2069454, rs2069456 and rs2069459, predicted to affect transcription, were found to be bimorphic...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753050/symptoms-of-depression-and-adhd-in-relation-to-stimulant-medication-misuse-among-college-students
#17
Kari Benson, Kate Flory
BACKGROUND: The misuse of stimulant medications, commonly used for the treatment of attention-deficit/hyperactivity disorder (ADHD), is a concern on college campuses. OBJECTIVE: This study sought to examine the relations between the misuse of stimulant medications and symptoms of depression and ADHD. METHOD: Eight hundred and ninety students ages 18-26 from one public university took a web-based survey including rating scales measuring symptoms of depression and ADHD...
July 28, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28744950/neural-signature-of-inattentional-deafness
#18
Gautier Durantin, Frederic Dehais, Nicolas Gonthier, Cengiz Terzibas, Daniel E Callan
Inattentional deafness is the failure to hear otherwise audible sounds (usually alarms) that may occur under high workload conditions. One potential cause for its occurrence could be an attentional bottleneck that occurs when task demands are high, resulting in lack of resources for processing of additional tasks. In this fMRI experiment, we explore the brain regions active during the occurrence of inattentional deafness using a difficult perceptual-motor task in which the participants fly through a simulated Red Bull air race course and at the same time push a button on the joystick to the presence of audio alarms...
July 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28742115/mind-wandering-during-attention-performance-effects-of-adhd-inattention-symptomatology-negative-mood-ruminative-response-style-and-working-memory-capacity
#19
Lisa M Jonkman, C Rob Markus, Michael S Franklin, Jens H van Dalfsen
OBJECTIVE: In adulthood, depressive mood is often comorbid with ADHD, but its role in ADHD-inattentiveness and especially relations with mind wandering remains to be elucidated. This study investigated the effects of laboratory-induced dysphoric mood on task-unrelated mind wandering and its consequences on cognitive task performance in college students with high (n = 46) or low (n = 44) ADHD-Inattention symptomatology and Hyperactivity/Impulsivity symptoms in the normal range. METHODS: These non-clinical high/low ADHD-Inattention symptom groups underwent negative or positive mood induction after which mind wandering frequency was measured in a sustained attention (SART), and a reading task...
2017: PloS One
https://www.readbyqxmd.com/read/28741400/high-prevalence-of-dysgraphia-in-elementary-through-high-school-students-with-adhd-and-autism
#20
Susan D Mayes, Rosanna P Breaux, Susan L Calhoun, Sara S Frye
OBJECTIVE: Prevalence of dysgraphia by age across all grade levels was determined in students with ADHD or autism. METHOD: Referred children with normal intelligence and ADHD-Combined, ADHD-Inattentive, or autism ( N = 1,034) were administered the Developmental Test of Visual-Motor Integration (VMI) and Wechsler Intelligence Scale for Children (WISC). RESULTS: VMI and WISC Coding scores were significantly lower than IQ and the normal mean of 100 for all diagnoses...
July 1, 2017: Journal of Attention Disorders
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