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https://www.readbyqxmd.com/read/29910786/characteristics-of-carbapenem-resistant-enterobacteriaceae-in-ready-to-eat-vegetables-in-china
#1
Bao-Tao Liu, Xiao-Yan Zhang, Shu-Wei Wan, Jun-Jie Hao, Rui-De Jiang, Feng-Jing Song
Vegetables harboring bacteria resistant to antibiotics are a growing food safety issue. However, data concerning carbapenem-resistant Enterobacteriaceae (CRE) in ready-to-eat fresh vegetables is still rare. In this study, 411 vegetable samples from 36 supermarkets or farmer's markets in 18 cities in China, were analyzed for CRE. Carbapenemase-encoding genes and other resistance genes were analyzed among the CRE isolates. Plasmids carrying carbapenemase genes were studied by conjugation, replicon typing, S1-PFGE southern blot, restriction fragment length polymorphism (RFLP), and sequencing...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29891605/-in-vitro-activity-of-ceftazidime-avibactam-against-carbapenem-resistant-and-hypervirulent-klebsiella-pneumoniae-isolates
#2
Fangyou Yu, Jingnan Lv, Siqiang Niu, Hong Du, Yi-Wei Tang, Robert A Bonomo, Barry N Kreiswirth, Liang Chen
Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) strains have emerged while antimicrobial treatment options remain limited. Herein, we tested the in vitro activity of ceftazidime-avibactam and other comparator antibiotics against 65 CR-hvKp isolates. Ceftazidime-avibactam, colistin and tigecycline are highly active in vitro against CR-hvKp isolates (MIC90 ≤ 1μg/ml), including KPC-2-producing ST11 CR-hvKp. Based upon previous clinical experience and the in vitro data presented herein, we posit that ceftazidime-avibactam is a considered therapeutic option against CR-hvKp infections...
June 11, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29847328/getting-hypervirulent-klebsiella-pneumoniae-on-the-radar-screen
#3
John A Sellick, Thomas A Russo
PURPOSE OF REVIEW: Two pathotypes of Klebsiella pneumoniae cause human infections, classical (cKp) and hypervirulent (hvKp) K. pneumoniae. The present understanding of genetic elements, the need for an accurate test to identify hvKp, the clinical implications of infection, the knowledge gap on how and why hvKp colonization transitions to infection, and potential infection prevention and control issues for hvKp are discussed. RECENT FINDINGS: Infections because of hvKp are increasingly recognized worldwide...
May 29, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29692580/virulence-determinant-and-extended-spectrum-beta-lactamase-production-in-klebsiella-pneumoniae-isolated-from-a-tertiary-care-hospital-south-india
#4
Lathamani Kotekani, Subbannayya Kotigadde
BACKGROUND: Klebsiella pneumoniae on these days show greater resistance towards newer generation cephalosporin. The present study made an effort to show the relevance between ESBL producing K. pneumoniae and virulence determinant in respect to serum resistance and K1, K2 antigens at a tertiary care hospital in South India. MATERIAL AND METHODS: A total of 520 consecutive, non-duplicate isolates of K. pneumoniae were recovered from various clinical specimens such as Urine (n = 360), sputum (n = 107), pus (n = 25), blood (n = 6) and other miscellaneous specimens (n=22) obtained from both out patients and in patients between June 2012 to July 2016 were included in the study...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29618511/structural-and-functional-delineation-of-aerobactin-biosynthesis-in-hypervirulent-klebsiella-pneumoniae
#5
Daniel C Bailey, Evan Alexander, Matthew R Rice, Eric J Drake, Lisa S Mydy, Courtney C Aldrich, Andrew M Gulick
Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role in mediating the enhanced virulence of a hypervirulent pathotype of Klebsiella pneumoniae (hvKP). In contrast to classical opportunistic strains of K. pneumoniae , hvKP causes serious life-threatening infections in previously healthy individuals in the community...
May 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29537694/presence-and-characterization-of-klebsiella-pneumoniae-from-the-intestinal-tract-of-diarrhoea-patients
#6
X Zhang, L Wang, R Li, P Hou, Y Zhang, M Fang, B Hu
The objective of this study was to investigate the presence and characterization of Klebsiella pneumoniae (KP) from the intestinal tract. Forty-three KP strains were isolated from 551 stool specimens from diarrhoea patients from 2013 to 2016, with a carriage rate of 7·80%. All isolates were hypervirulent KP strains with hypermucoviscosity phenotype. The virulence factors and antibiotic resistance exhibited diverse distribution. 2·33% (1/43), 2·33% (1/43), 6·98% (3/43), 6·98% (3/43), 4·65% (2/43), 11·63% (5/43) and 18·60% (8/43) were identified as serotypes of K1, K2, K3, K5, K20, K54 and K57 respectively...
June 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29433440/whole-genome-analysis-of-hypervirulent-klebsiella-pneumoniae-isolates-from-community-and-hospital-acquired-bloodstream-infection
#7
Chaitra Shankar, Balaji Veeraraghavan, Laura Eve Buchnan Nabarro, Raji Ravi, Naveen Kumar Devanga Ragupathi, Priscilla Rupali
BACKGROUND: Hypervirulent K. pneumoniae (hvKp) causes severe community acquired infections, predominantly in Asia. Though initially isolated from liver abscesses, they are now prevalent among invasive infections such as bacteraemia. There have been no studies reported till date on the prevalence and characterisation of hvKp in India. The objective of this study is to characterise the hypervirulent strains isolated from bacteraemic patients for determination of various virulence genes and resistance genes and also to investigate the difference between healthcare associated and community acquired hvKp with respect to clinical profile, antibiogram, clinical outcome and molecular epidemiology...
January 8, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29338592/whole-genome-sequencing-characterization-of-bloodstream-infection-causing-hypervirulent-klebsiella-pneumoniae-of-capsular-serotype-k2-and-st374
#8
Xiaoli Wang, Yingzhou Xie, Gang Li, Jialin Liu, Xiaobin Li, Lijun Tian, Jingyong Sun, Hong-Yu Ou, Hongping Qu
Hypervirulent K. pneumoniae variants (hvKP) have been increasingly reported worldwide, causing metastasis of severe infections such as liver abscesses and bacteremia. The capsular serotype K2 hvKP strains show diverse multi-locus sequence types (MLSTs), but with limited genetics and virulence information. In this study, we report a hypermucoviscous K. pneumoniae strain, RJF293, isolated from a human bloodstream sample in a Chinese hospital. It caused a metastatic infection and fatal septic shock in a critical patient...
January 1, 2018: Virulence
https://www.readbyqxmd.com/read/29319515/the-determination-and-correlation-of-various-virulence-genes-esbl-serum-bactericidal-effect-and-biofilm-formation-of-clinical-isolated-classical-klebsiella-pneumoniae-and-hypervirulent-klebsiella-pneumoniae-from-respiratory-tract-infected-patients
#9
Rambha K Shah, Zhao H Ni, Xiao Y Sun, Guo Q Wang, Fan Li
Klebsiella pneumoniae strains that are commonly recognized by clinicians and microbiologists are termed as classical K. pneumoniae (cKP). A strain with capsule-associated mucopolysaccharide web is known as hypervirulent K. pneumoniae (hvKP) as it enhances the serum resistant and biofilm production. Aim is to determine and correlate various virulence genes, ESBL, serum bactericidal effect and biofilm formation of clinical isolated cKP and hvKP from respiratory tract infected patients. A total of 96 K. pneumoniae strains were isolated from sputum of respiratory tract infected patients...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29286017/a-case-of-invasive-infection-caused-by-a-highly-virulent-strain-of-klebsiella-pneumoniae-displaying-hypermucoviscosity-in-a-patient-with-hepatic-involvement-without-liver-abscess
#10
Margherita Scapaticci, Marta Biscaro, Francesco Burelli, Lucio Cadamuro, Renzo Biscaro, Andrea Bartolini
Klebsiella pneumoniae is an opportunistic nosocomial pathogen belonging to the Enterobacteriaceae family that is associated with a wide range of infections. In the 1980s a new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae (hvKP) emerged in southeast Asia and is now increasingly spreading to Western countries due to an invasive syndrome. hvKP isolates can cause serious, life-threatening community-acquired infections in younger healthy hosts, including liver abscess, pneumonia, meningitis and endophthalmitis...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29238932/risk-factors-and-clinical-outcomes-of-hypervirulent-klebsiella-pneumoniae-induced-bloodstream-infections
#11
Jiayang Li, Jianan Ren, Weiping Wang, Gefei Wang, Guosheng Gu, Xiuwen Wu, Ying Wang, Mei Huang, Jieshou Li
The prevalence of hypervirulent Klebsiella pneumoniae (hvKP) is high in China, but clinical characteristics and outcomes of hvKP induced bloodstream infections (BSIs) are not clear. The purpose of the present study was to determine the risk factors and clinical outcomes of hvKP-BSIs in populations admitted in a teaching hospital of Nanjing, China. The genetic characteristics and antibiotic resistance patterns of the hvKP strains were further analyzed. A retrospective study was conducted in 143 patients with K...
April 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29228178/genome-sequence-analysis-of-a-hypermucoviscous-hypervirulent-and-mdr-ctx-m-15-k19-st29-klebsiella-pneumoniae-isolated-from-human-infection
#12
Quézia Moura, Fernanda Esposito, Miriam R Fernandes, Maria Espinoza-Muñoz, Tiago A Souza, Silvia R Santos, Louise Cerdeira, Valéria Cassettari, Nilton Lincopan
The emergence of hypervirulent Klebsiella pneumoniae (hvKP) with multidrug resistance (MDR) profile is a worrisome public health issue. We report the first draft genome sequence of a hypermucoviscous (positive string test) and MDR K. pneumoniae serotype K19, belonging to ST29, isolated from human infection. This strain harboured multiple antimicrobial resistance genes, including blaCTX-M-15, besides yersiniabactin and type 3 fimbriae virulence genes. In vivo experiments carried out with the Galleria mellonella infection model revealed that K...
December 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29051525/virulence-characteristics-of-carbapenem-resistant-klebsiella-pneumoniae-strains-from-patients-with-necrotizing-skin-and-soft-tissue-infections
#13
Fiorella Krapp, Andrew R Morris, Egon A Ozer, Alan R Hauser
Two types of Klebsiella pneumoniae (KP) strains are currently emerging: hypervirulent (hvKP) strains and carbapenem-resistant (CR-KP) strains. To date, these two strain types rarely overlap. Recent reports, however, suggest that CR-KP strains are increasing in virulence. hvKP strains frequently present as highly invasive infections, such as necrotizing skin and soft tissue infections (NSSTI). To examine whether CR-KP strains with features of hvKP were present in our U.S. hospital, we retrospectively identified four cases of CR-KP NSSTI diagnosed between January 2012 and January 2016...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28936426/comparison-of-diabetic-and-non-diabetic-human-leukocytic-responses-to-different-capsule-types-of-klebsiella-pneumoniae-responsible-for-causing-pyogenic-liver-abscess
#14
I Russel Lee, Ethel Sng, Kok-Onn Lee, James S Molton, Monica Chan, Shirin Kalimuddin, Ezlyn Izharuddin, David C Lye, Sophia Archuleta, Yunn-Hwen Gan
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but diabetic status had no effect on these neutrophil extracellular trap (NET) biomarkers in both subject groups...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28717029/metabolite-transporter-peg344-is-required-for-full-virulence-of-hypervirulent-klebsiella-pneumoniae-strain-hvkp1-after-pulmonary-but-not-subcutaneous-challenge
#15
Jeffrey Bulger, Ulrike MacDonald, Ruth Olson, Janet Beanan, Thomas A Russo
Hypervirulent Klebsiella pneumoniae (hvKP) is an emerging pathotype that is capable of causing tissue-invasive and organ- and life-threatening infections in healthy individuals from the community. Knowledge on the virulence factors specific to hvKP is limited. In this report, we describe a new factor (PEG344) that increases the virulence of hvKP strain hvKP1. peg-344 is present on the hvKP1 virulence plasmid, is broadly prevalent among hvKP strains, and has increased RNA abundance when grown in human ascites...
October 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28282434/resistance-of-hypervirulent-klebsiella-pneumoniae-to-both-intracellular-and-extracellular-killing-of-neutrophils
#16
Lifeng Wang, Dingxia Shen, Hua Wu, Yanning Ma
Hypervirulent Klebsiella pneumoniae (HvKP) is hypermucoviscous organism, carrying genes of rmpA and aerobactin, causing serious community-acquired infection and metastatically spread in young healthy hosts. Neutrophils play an important role during innate immune response against bacterial infection by phagocytosis and neutrophil extracellular traps (NETs). Whether neutrophils can effectively defend against HvKP remains unclear. In this study, we observed that the HvKP was significantly more resistant to neutrophil-mediated phagocytosis and intracellular killing than classic Klebsiella pneumoniae (cKP) isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28132768/bacteremia-and-other-body-site-infection-caused-by-hypervirulent-and-classic-klebsiella-pneumoniae
#17
Hua Wu, Dongdong Li, Haijian Zhou, Yunfang Sun, Ling Guo, Dingxia Shen
OBJECTIVES: To investigate bacteremia and other body site infection caused by hypervirulent Klebsiella pneumoniae (hvKP), a recently recognized pathogen of invasive infection, and classic Klebsiella pneumoniae (cKP), a very common organism associated with many kinds of nosocomial infection. METHODS: Clinical information obtained from patients with both bacteremia and other body site infections caused by hvKP and/or cKP was retrospectively reviewed. Homo-hvKP (or homo-cKP) was defined as homologous hvKP (or cKP) strains from different body sites in each individual patient according to string test, virulence gene amplification and PFGE pattern...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27965935/clinical-and-genomic-analysis-of-liver-abscess-causing-klebsiella-pneumoniae-identifies-new-liver-abscess-associated-virulence-genes
#18
Meiping Ye, Jianfei Tu, Jianping Jiang, Yingmin Bi, Weibo You, Yanliang Zhang, Jianmin Ren, Taohui Zhu, Zhuo Cao, Zuochun Yu, Chuxiao Shao, Zhen Shen, Baixing Ding, Jinyi Yuan, Xu Zhao, Qinglan Guo, Xiaogang Xu, Jinwei Huang, Minggui Wang
Hypervirulent variants of Klebsiella pneumoniae (hvKp) that cause invasive community-acquired pyogenic liver abscess (PLA) have emerged globally. Little is known about the virulence determinants associated with hvKp, except for the virulence genes rmpA/A2 and siderophores ( iroBCD/iucABCD ) carried by the pK2044-like large virulence plasmid. Here, we collected most recent clinical isolates of hvKp from PLA samples in China, and performed clinical, molecular, and genomic sequencing analyses. We found that 90...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27923372/community-acquired-meningitis-caused-by-a-cg86-hypervirulent-klebsiella-pneumoniae-strain-first-case-report-in-the-caribbean
#19
Bénédicte Melot, Sylvain Brisse, Sébastien Breurec, Virginie Passet, Edith Malpote, Isabelle Lamaury, Guillaume Thiery, Bruno Hoen
BACKGROUND: Community-acquired bacterial meningitis due to Klebsiella pneumoniae has mainly been described in Southeast Asia and has a poor prognosis. Severe invasive infections caused by K. pneumoniae, including meningitis, are often due to hypervirulent strains (hvKP), which are characterized by capsular serotypes K1 and K2, a gene responsible for hypermucoviscosity, and the cluster for synthesis of the siderophore aerobactin. CASE PRESENTATION: A 55 year old man with a history of essential hypertension, benign prostate hyperplasia, hyperlipidemia, obstructive sleep apnea, and chronic alcoholism was admitted for meningitis due to Klebsiella pneumoniae with a wild-type susceptibility profile...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27895637/high-prevalence-of-esbl-producing-klebsiella-pneumoniae-causing-community-onset-infections-in-china
#20
Jing Zhang, Kai Zhou, Beiwen Zheng, Lina Zhao, Ping Shen, Jinru Ji, Zeqing Wei, Lanjuan Li, Jianying Zhou, Yonghong Xiao
The aim of this work was to investigate the epidemiological and genetic characteristics of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) causing community-onset infections. K. pneumoniae isolates were collected from 31 Chinese secondary hospitals between August 2010 and 2011. Genes encoding ESBL and AmpC beta-lactamases were detected by PCR. The isolates were assigned to sequence types (STs) using multi-locus sequence typing (MLST). Eleven ESBL-Kp strains were selected for whole-genome sequencing (WGS) for investigating the genetic environment and plasmids encoding ESBL genes...
2016: Frontiers in Microbiology
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