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Gallbladder cancer

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https://www.readbyqxmd.com/read/29142904/kras-g12d-upregulates-notch-signaling-to-induce-gallbladder-tumorigenesis-in-mice
#1
Wen-Cheng Chung, Junqing Wang, Yunyun Zhou, Keli Xu
Background: Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether Notch deregulation played a role in this context. Methods: We determined Cre recombination activity of Pdx1-Cre in the gallbladder using a reporter strain and examined gallbladder tumor development in the Kras(LSL- G12D/+);Pdx1-Cre mice...
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29138340/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-patients-with-egfr-positive-advanced-biliary-tract-cancers
#2
Yelei Guo, Kai-Chao Feng, Yang Liu, Zhiqiang Wu, Hanren Dai, Qing-Ming Yang, Yao Wang, Hejin Jia, Weidong Han
PURPOSE: This study is an expanded and parallel clinical trial of epidermal growth factor receptor (EGFR)-specific chimeric antigen receptor-engineered autologous T (CART) cell immunotherapy (NCT01869166) to assess the safety and activity of CART-EGFR cell therapy in EGFR-positive advanced unresectable, relapsed/metastatic biliary tract cancers (BTCs). PATIENTS AND METHODS: Patients with EGFR-positive (>50%) advanced unresectable, relapsed/metastatic BTCs were enrolled...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29117469/optimal-extent-of-surgery-for-early-gallbladder-cancer-with-regard-to-long-term-survival-a-meta-analysis
#3
Hongeun Lee, Wooil Kwon, Youngmin Han, Jae Ri Kim, Sun-Whe Kim, Jin-Young Jang
BACKGROUND/PURPOSE: The optimal surgical extent for T1 gallbladder cancer (GBC) remains controversial. Simple cholecystectomy is routinely performed for T1 GBC while several guidelines recommend extended cholecystectomy for T1b GBC. However, evidence regarding the optimal surgical extent for T1 GBC is lacking. This study aims to systematically evaluate the optimal surgical extent for early GBC with regard to long-term survival. METHODS: A comprehensive literature search in MEDLINE was performed to identify studies with histologically proven GBC and survival data...
November 8, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29114851/biweekly-cisplatin-and-gemcitabine-in-patients-advanced-biliary-tract-cancer
#4
Daniel H Ahn, Josh Reardon, Chul W Ahn, Manojkumar Bupathi, Sameh Mikhail, Christina Sing-Ying Wu, Tanios Bekaii-Saab
Treatment with cisplatin with gemcitabine (CG) demonstrates a survival benefit in patients with advanced biliary tract cancer (ABTC). However, the weekly administration can add significant toxicities that may prohibit prolonged treatment. Based on previous studies, we implemented a modified biweekly regimen of GC in an attempt to optimize the prescribed regimen with an improved toxicity profile, added convenience to patients while maintaining efficacy. Patients with ABTC were treated with fixed dose rate (FDR) gemcitabine (1000mg/m(2) /min) and cisplatin 20mg/m(2) on days 1 and 15 of every 28-day cycle...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29113399/dck-expression-a-potential-predictive-biomarker-in-the-adjuvant-gemcitabine-chemotherapy-for-biliary-tract-cancer-after-surgical-resection-results-from-a-phase-ii-study
#5
Sang Myung Woo, Kyong-Ah Yoon, Eun Kyung Hong, Weon Seo Park, Sung-Sik Han, Sang-Jae Park, Jungnam Joo, Eun Young Park, Ju Hee Lee, Yun-Hee Kim, Tae Hyun Kim, Woo Jin Lee
The role of adjuvant therapy following resection of biliary tract cancer (BTC) remains unclear. We therefore evaluated the feasibility and toxicity of adjuvant gemcitabine in patients with BTC. This clinical phase II trial was an open-label, single center, single-arm study. Within 8 weeks after gross complete resection of BTC, patients were started on intravenous infusions of gemcitabine 1000 mg/m(2) over 30 min on days 1, 8, and 15 of every 28-day cycle. Intratumoral expression of cytidine deaminase (CDA), human equilibrative transporter-1 (hENT1), deoxycytidine kinase (dCK) and ribonucleotide reductase subunit 1 (RRM1) was measured by immunohistochemistry...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110119/metformin-synergistically-enhances-antitumor-activity-of-cisplatin-in-gallbladder-cancer-via-the-pi3k-akt-erk-pathway
#6
Tingting Bi, Ao Zhu, Xufeng Yang, Huiying Qiao, Jinmei Tang, Yan Liu, Rong Lv
Metformin (Met) is a widely used antidiabetic drug and has demonstrated interesting anticancer effects in various cancer models, alone or in combination with chemotherapeutic drugs. The aim of the present study is to investigate the synergistic effect of Met with cisplatin (Cis) on the tumor growth inhibition of gallbladder cancer cells (GBC-SD and SGC-996) and explore the underlying mechanism. Cells were treated with Met and/or Cis and subjected to cell viability, colony formation, apoptosis, cell cycle, western blotting, xenograft tumorigenicity assay and immunohistochemistry...
November 6, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29109099/targeted-gene-sequencing-of-gallbladder-carcinoma-identifies-high-impact-somatic-and-rare-germline-mutations
#7
REVIEW
Saurabh Yadav, Navonil DE Sarkar, Niraj Kumari, Narendra Krishnani, Ashok Kumar, Balraj Mittal
BACKGROUND: Gallbladder carcinoma (GBC) is a subtype of biliary tract malignancy with poor prognosis and high fatality rate. The present study was designed to uncover somatic and rare germline mutations in GBC to reveal the disease biology and understand the clinical importance of mutation profile in terms of prognostics and actionability. MATERIALS AND METHODS: We performed ultra-deep sequencing across 409 cancer-related genes in 11 GBC patients of North-Indian descent...
November 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29108324/age-adjusted-charlson-comorbidity-index-score-as-predictor-of-survival-of-patients-with-digestive-system-cancer-who-have-undergone-surgical-resection
#8
Yaohua Tian, Zhong Jian, Beibei Xu, Hui Liu
Comorbidities have considerable effects on survival outcomes. The primary objective of this retrospective study was to examine the association between age-adjusted Charlson comorbidity index (ACCI) score and postoperative in-hospital mortality in patients with digestive system cancer who have undergone surgical resection of their cancers. Using electronic hospitalization summary reports, we identified 315,464 patients who had undergone surgery for digestive system cancer in top-rank (Grade 3A) hospitals in China between 2013 and 2015...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098452/synchronous-primary-gallbladder-and-pancreatic-cancer-associated-with-congenital-biliary-dilatation-and-pancreaticobiliary-maljunction
#9
Haruki Mori, Hiroya Iida, Hiromitsu Maehira, Naomi Kitamura, Tomoharu Shimizu, Masaji Tani
INTRODUCTION: Synchronous double cancer of the gallbladder and pancreas that is associated with congenital biliary dilatation (CBD) and pancreaticobiliary maljunction (PBM) is extremely rare. PBM is frequently reported in Asia, particularly in Japan. We report a surgical case of synchronous double cancer in a patient with primary gallbladder and pancreatic cancer. PRESENTATION OF CASE: A 72-year-old woman with epigastralgia underwent subtotal stomach-preserving pancreaticoduodenectomy and gallbladder bed resection for synchronous primary gallbladder and pancreatic head cancer...
November 2, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29079901/diabetes-and-the-pancreatobiliary-diseases
#10
REVIEW
Muhammad Shafqet, Kaveh Sharzehi
PURPOSE OF REVIEW: The emphasis of this review article is to bring to the forefront the spectrum of pancreatobiliary disorders and their association with diabetes. We hope to systematically discuss the link between diabetes and disorders of the pancreas including acute and chronic pancreatitis, as well as pancreatic cancer. We also hope to review and highlight the literature with respect to other cancers of the biliary tree including gallbladder and cholangiocarcinoma. Lastly, we discuss diabetes and biliary dyskinesia...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29076352/ethnic-disparities-in-cancer-incidence-and-survival-among-the-oldest-old-in-the-united-states
#11
Jessica L Krok-Schoen, Ingrid K Adams, Ryan D Baltic, James L Fisher
OBJECTIVE: To examine potential ethnic disparities in cancer incidence and survival rates among the oldest old using data from the SEER Program. DESIGN: Cases diagnosed with one of the leading four cancer sites (lung and bronchus, colon and rectum, female breast, prostate) and four cancer sites (stomach, liver and intrahepatic bile duct, gallbladder, and cervical) that disproportionally affect Hispanics were reported to one of 18 SEER registries. Differences in cancer incidence were examined for cases aged ≥85 years diagnosed during the most recent 5-year time period (2009-2013) and, to examine changes over time, from 1992 to 2013...
October 27, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29075490/synchronous-multiple-primary-gallbladder-and-gastric-malignancies-report-of-two-cases-and-review-of-the-literature
#12
Shuo Zhou, Zheng Lu, Hua Wu, Cong-You Gu, Deng-Yong Zhang, Wan-Liang Sun, Xiang Ma, Hui-Chun Liu
Multiple primary malignancies (MPM) are rare. In particular, synchronous gallbladder and gastric malignancies are extremely rare, are associated with a concealed onset and atypical symptoms, and are highly likely to be overlooked or misdiagnosed. The clinical data of two patients with synchronous gallbladder and gastric malignancies are herein reported and integrated with the relevant literature to retrospectively analyze and summarize the pathogenesis and clinical characteristics of MPM. Case 1 was a male 46-year-old patient who underwent laparoscopic cholecystectomy, and succumbed to extensive tumor metastasis 2 months after the operation...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29069888/tumor-marker-kinetics-as-prognosticators-in-patients-with-unresectable-gallbladder-adenocarcinoma-undergoing-palliative-chemotherapy
#13
Jae Woo Lee, Yong-Tae Kim, Sang Hyub Lee, Jun Hyuk Son, Jin Woo Kang, Ji Kon Ryu, Dong Kee Jang, Woo Hyun Paik, Ban Seok Lee
Background/Aims: To determine the prognostic value of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in gallbladder cancer (GBC) during palliative chemotherapy. Methods: One hundred and twenty-three patients with pathologically confirmed unresectable GBC were included. Differences in serum CEA and CA 19-9 levels before and after chemotherapy were measured. Receiver operating characteristic curve analysis, Kaplan-Meier analyses of CEA, CA 19-9, and combined changes were performed to assess the optimal cutoff values and survival rates...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29063951/-biliary-tract-cancers-molecular-characterization-and-identification-of-novel-prognostic-markers
#14
REVIEW
B Goeppert
BACKGROUND: Bile duct cancers (BTCs) are highly aggressive tumors with a dismal prognosis and an increasing incidence. BTC is a tumorbiologically and clinically heterogeneous tumor group and can be subdivided according to anatomical aspects into intrahepatic cholangiocarcinomas (iCCA), extrahepatic cholangiocarcinomas (eCCA) and gallbladder carcinomas (GBC). NEW THERAPY OPTIONS: Chronic inflammatory processes of the biliary system seem to play a role in the development of these tumors...
October 24, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29063057/clinical-epidemiological-survey-of-gallbladder-carcinoma-in-northwestern-china-2009-2013-2379-cases-in-17-centers
#15
Hao-Xin Shen, Hu-Wei Song, Xin-Jian Xu, Zuo-Yi Jiao, Zhen-Yu Ti, Zhao-Yu Li, Bin Ren, Chen Chen, Li Ma, Ya-Ling Zhao, Guan-Jun Zhang, Jian-Cang Ma, Xi-Lin Geng, Xiao-Di Zhang, Jing-Sen Shi, Lin Wang, Zhi-Min Geng
OBJECTIVE: To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces of China (Shaanxi Province, Gansu Province, Qinghai Province, Ningxia Hui Autonomous Region, and Xinjiang Uygur Autonomous Region) from 2009 to 2013, and to summarize the clinical diagnosis and treatment data of gallbladder carcinoma. METHODS: Clinical information of 2379 patients with gallbladder carcinoma from 17 hospitals in five northwestern provinces of China was retrospectively collected and analyzed using the "Questionnaire for Gallbladder Carcinoma Patients in Northwestern Area of China...
March 25, 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/29061828/effect-of-adjuvant-gemcitabine-combined-with-low-dose-5-fluorouracil-and-cisplatin-chemotherapy-for-advanced-biliary-carcinoma
#16
Yuji Morine, Mitsuo Shimada, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Y U Saito, Shinichiro Yamada, Satoru Imura
BACKGROUND/AIM: The aim of this retrospective study was to clarify the effectiveness of chemotherapy with gemcitabine combined with low-dose 5-fluorouracil and cisplatin (GFP) for advanced biliary carcinoma after hepatectomy. PATIENTS AND METHODS: Sixty-two patients had biliary carcinoma with lymph node metastasis, intrahepatic metastasis or positive surgical margins, including intrahepatic cholangiocarcinoma (IHC, n=25), hilar cholangiocarcinoma (HC, n=14), and gallbladder cancer (GBC, n=23)...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29058818/prognostic-significance-of-long-non-coding-rna-malat1-for-predicting-the-recurrence-and-metastasis-of-gallbladder-cancer-and-its-effect-on-cell-proliferation-migration-invasion-and-apoptosis
#17
Ke-Ke Sun, Ping-Ping Hu, Feng Xu
The objective of this study is to explore the role of MALAT1 as a molecular indicator in predicting the recurrence, metastasis and prognosis of gallbladder cancer (GBC) and its effect on the proliferation, invasion, migration, and apoptosis of GBC cells in vitro. GBC tissues and adjacent normal tissues were collected from 102 patients. MALAT1 short hairpin RNA (shRNA) plasmids were first constructed to transfect the GBC-SD cells. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was applied to detect MALAT1 expression...
October 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29052825/managing-endoscopic-retrograde-cholangiopancreatography-related-complications-in-patients-referred-to-the-surgical-emergency-unit
#18
Osman Şimşek, Arife Şimşek, Sefa Ergun, Mehmet Velidedeoğlu, Kaya Sarıbeyoğlu, Salih Pekmezci
BACKGROUND: The goal of this study was to present our experience in the management of endoscopic retrograde cholangiopancreatography-related complications in patients referred to our surgical emergency unit by various endoscopy centers. METHODS: A retrospective investigation was conducted on the records of the 54 patients who were referred to our surgical emergency unit between October 2005 and January 2014 due to endoscopic retrograde cholangiopancreatography-related complications...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29043607/ddr2-and-ifitm1-are-prognostic-markers-in-gallbladder-squamous-cell-adenosquamous-carcinomas-and-adenocarcinomas
#19
Daiqiang Li, Zhulin Yang, Ziru Liu, Qiong Zou, Yuan Yuan
This study was conducted to investigate the expressions of DDR2 and IFITM1 and their clinical and pathological significances in the rare type squamous cell/adenosquamous carcinomas (SC/ASC) and ordinary adenocarcinomas (AC) of gallbladder cancers. DDR2 and IFITM1 expression was examined in 69 SC/ASCs and 146 ACs using EnVision immunohistochemistry. Results showed that the percentage of positive DDR2 and IFITM1 expression was significantly higher in SC/ASC patients with high TNM stage, lymph node metastasis, invasion, and no resection surgery compared to patients with low TNM stages, no lymph node metastasis, no invasion, and resection surgery (P < 0...
October 17, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29042975/comparison-of-dwibs-t2-image-fusion-and-pet-ct-for-the-diagnosis-of-cancer-in-the-abdominal-cavity
#20
Minoru Tomizawa, Fuminobu Shinozaki, Yoshitaka Uchida, Katsuhiro Uchiyama, Satomi Tanaka, Takafumi Sunaoshi, Daisuke Kano, Eriko Sugiyama, Misaki Shite, Ryouta Haga, Yoshiya Fukamizu, Toshiyuki Fujita, Satoshi Kagayama, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively...
October 2017: Experimental and Therapeutic Medicine
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