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Gallbladder cancer

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https://www.readbyqxmd.com/read/29778567/emp3-which-is-regulated-by-mir-663a-suppresses-gallbladder-cancer-progression-via-interference-with-the-mapk-erk-pathway
#1
Qiang Ma, Yijian Zhang, Haibin Liang, Fei Zhang, Fatao Liu, Shili Chen, Yunping Hu, Lin Jiang, Yajuan Hao, Maolan Li, Yingbin Liu
Gallbladder cancer (GBC) is the most common malignancy of the biliary tract and its molecular pathogenesis is poorly understood. Aberrant expression of epithelial membrane protein-3 (EMP3) was reported in different kinds of cancers. Our study aimed to explore the elusive functional roles and the underlying molecular mechanisms of EMP3 with respect to GBC progression. The results showed that human GBC tissues exhibited decreased levels of EMP3 compared with non-malignant tissues. Kaplan-Meier analysis indicated that low expression of EMP3 was associated with poor prognosis of GBC patients...
May 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29761515/association-of-perioperative-transfusion-with-survival-and-recurrence-after-resection-of-gallbladder-cancer-a-10-institution-study-from-the-us-extrahepatic-biliary-malignancy-consortium
#2
Alexandra G Lopez-Aguiar, Cecilia G Ethun, Mia R McInnis, Timothy M Pawlik, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza W Beal, Ioannis Hatzaras, Rivfka Shenoy, Kenneth Cardona, Shishir K Maithel
BACKGROUND AND OBJECTIVES: Perioperative blood transfusion is associated with poor outcomes in several malignancies. Its effect in gallbladder cancer (GBC) is unknown. METHODS: All patients with GBC who underwent curative-intent resection at 10-institutions from 2000 to 2015 were included. The effect of blood transfusion on overall survival (OS) and recurrence-free (RFS) was evaluated. RESULTS: Of 262 patients with curative-intent resection for GBC, 61 patients (23%) received blood transfusions...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29760576/trends-of-gallbladder-cancer-in-jordan-over-2-decades-where-are-we
#3
Abdel Rahman Al Manasra, Mohammed Bani Hani, Haitham Qandeel, Samer Al Asmar, Mohammad Alqudah, Nabil Al-Zoubi, Satish Nadig, Shadi Hamouri, Khaled Obeidat, Nada Al-Muqaimi
Background and Study Aims: The prevalence of gallbladder cancer (GBC) varies between different parts of the world. This study is a review of literature and an update of a previously published study conducted in our university and aims to reassess the incidence of GBC over the past 2 decades. Patients and Methods: We conducted a retrospective study between 2002 and 2016. Data regarding demographics, clinical presentation, risk factors, histopathology, investigations, and treatments were obtained...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29758925/the-emerging-roles-of-long-non-coding-rna-in-gallbladder-cancer-tumorigenesis
#4
Bing Chen, Ya Li, Yuting He, Chen Xue, Feng Xu
Accumulating evidence suggests that long non-coding RNAs (lncRNAs) have important regulatory functions in gallbladder cancer (GBC) tumorigenesis and can serve as potential novel markers and/or targets for GBC. In this review, we critically discuss the emerging alteration of lncRNAs in GBC, the lncRNAs induced epigenetic regulation, the interaction of lncRNAs with microRNAs and lncRNAs effects on tumor-related signaling pathways. Additionally, contributions of lncRNAs in epithelial-mesenchymal transition process and energy metabolism reprogramming in GBC are also addressed...
May 4, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29757003/transglutaminase-2-mediates-the-cytotoxicity-of-resveratrol-in-a-human-cholangiocarcinoma-and-gallbladder-cancer-cell-lines
#5
Leda Roncoroni, Luca Elli, Paola Braidotti, Delfina Tosi, Valentina Vaira, Lorenza Tacchini, Vincenza Lombardo, Federica Branchi, Alice Scricciolo, Luisa Doneda
Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Our aim was to evaluate if the cytotoxic effect of resveratrol (RES) on cholangiocarcinoma (CC) and gallbladder cancer (GBC) cell lines could be abolished by TG2 inhibition. Human CC and GBC cell lines (SK-ChA-1 and MZ-ChA-1), grown in a three-dimensional cell culture system (MCTS, multicellular tumor spheroids), were treated for 72 h with RES (32, 64 µM) alone or combined with different TG2 inhibitors (Cystamine, B003, T101)...
May 14, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29755774/racial-ethnic-disparities-in-gallbladder-cancer-receipt-of-treatments
#6
Veeravich Jaruvongvanich, Buravej Assavapongpaiboon, Linda Wong
Background: Gallbladder cancer is a rare malignancy, yet it has a dismal prognosis. Overall survival has improved in all races/ethnicities except Hispanics and blacks. Despite improvements in gallbladder cancer management, it is not clear whether racial/ethnic disparities in stage at diagnosis and treatments exist that could potentially be the source of survival disparities. The purpose of this study was to examine race/ethnicity-specific trends in the stage of disease and receipt of treatments among adult gallbladder cancer patients in the US...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29740203/olfactomedin-4-in-digestive-diseases-a-mini-review
#7
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29736837/establishment-of-a-gallbladder-cancer-specific-survival-model-to-predict-prognosis-in-non-metastatic-gallbladder-cancer-patients-after-surgical-resection
#8
Woods Zhang, H J Hong, Yan-Ling Chen
BACKGROUND: Gallbladder cancer is an invasive cancer with a discouraging prognosis, and early detection and active intervention are of great value. AIMS: To establish a more accurate and effective survival model to predict the prognosis of patients with non-metastatic gallbladder after surgical resection. METHODS: A retrospective analysis was conducted in non-metastatic gallbladder cancer patients who were registered in the surveillance, epidemiology and end results database from 2010 to 2014...
May 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29728459/abcg5-and-abcg8-more-than-a-defense-against-xenosterols
#9
Shailendra B Patel, Gregory Graf, Ryan Temel
The elucidation of the molecular basis of the rare disease Sitosterolemia has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body. Two proteins ABCG5 and ABCG8, encoded by the Sitosterolemia locus, work as obligate dimers to pump sterols out of hepatocytes and enterocytes. ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree, as well as the intestinal tract. Importantly, these transporters keep xenosterols from accumulating in the body...
May 4, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29723410/the-association-between-preoperative-serum-interleukin-6-levels-and-postoperative-prognosis-in-patients-with-t2-gallbladder-cancer
#10
Jianfa Wang, Jiazhe Liu, Qimeng Chang, Biao Yang, Sen Li, Chao Gu
BACKGROUND: Interleukin-6 (IL-6) is closely associated with tumor progression. Whether it can predict postoperative prognosis of patients with T2 gallbladder cancer (GBC) remains controversial. METHODS: We retrospectively collected the medical records of 125 patients with T2 GBC. Then, we analyzed the association between preoperative serum IL-6 levels and postoperative survival by multivariate Cox analyses and Kaplan-Meier curves in exploratory subgroups. RESULTS: Predictive effects of serum IL-6 levels on overall survival were similar across most of the evaluated subgroups, except in different tumor location subgroups...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29722272/gallbladder-cancer-a-journey-of-a-thousand-steps
#11
Savio G Barreto, Amit Dutt, Bhawna Sirohi, Shailesh V Shrikhande
This article traces the journey of one of the teams from India that has been actively managing and researching gallbladder cancer for more than a decade, providing insights into the work carried out and highlighting areas that warrant future research in this cancer traditionally known for its dismal outcomes.
May 3, 2018: Future Oncology
https://www.readbyqxmd.com/read/29718843/predicting-the-risk-for-colorectal-cancer-with-personal-characteristics-and-fecal-immunochemical-test
#12
Wen Li, Li-Zhong Zhao, Dong-Wang Ma, De-Zheng Wang, Lei Shi, Hong-Lei Wang, Mo Dong, Shu-Yi Zhang, Lei Cao, Wei-Hua Zhang, Xi-Peng Zhang, Qing-Huai Zhang, Lin Yu, Hai Qin, Xi-Mo Wang, Sam Li-Sheng Chen
We aimed to predict colorectal cancer (CRC) based on the demographic features and clinical correlates of personal symptoms and signs from Tianjin community-based CRC screening data.A total of 891,199 residents who were aged 60 to 74 and were screened in 2012 were enrolled. The Lasso logistic regression model was used to identify the predictors for CRC. Predictive validity was assessed by the receiver operating characteristic (ROC) curve. Bootstrapping method was also performed to validate this prediction model...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29714811/gallbladder-carcinoma-an-analysis-of-the-national-cancer-data-base-to-examine-hispanic-influence
#13
Chrissy Liu, Nicholas G Berger, Lisa Rein, Sergey Tarima, Callisia Clarke, Harveshp Mogal, Kathleen K Christians, Susan Tsai, T Clark Gamblin
BACKGROUND: Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non-Hispanic populations. METHODS: Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29709218/clues-to-predict-incidental-gallbladder-cancer
#14
Naeem Goussous, Hadia Maqsood, Kalpesh Patel, Hamid Ferdosi, Naseem Muhammad, Anne M Sill, Gopal C Kowdley, Steven C Cunningham
BACKGROUND: Consequences of incidental gallbladder cancer (iGBC) following cholecystectomy may include repeat operation (depending on T stage) and worse survival (if bile spillage occurred), both avoidable if iGBC were suspected preoperatively. METHODS: A retrospective single-institution review was done. Ultrasound images for cases and controls were blindly reviewed by a radiologist. Chi-square and Student's t tests, as well as logistic regression and Kaplan-Meier analyses were used...
April 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29706425/outcome-of-neoadjuvant-chemotherapy-in-locally-advanced-borderline-resectable-gallbladder-cancer-the-need-to-define-indications
#15
Vikram A Chaudhari, Vikas Ostwal, Shraddha Patkar, Arvind Sahu, Anup Toshniwal, Anant Ramaswamy, Nitin S Shetty, Shailesh V Shrikhande, Mahesh Goel
BACKGROUND: Studies evaluating neo-adjuvant chemotherapy (NACT) exclusively in gallbladder cancer (GBC) are few and there are no randomized trials on the subject. Locally advanced GBC and indications for NACT in GBC are not yet clearly defined. METHODS: We analysed 160 consecutive GBC patients who received NACT based on clinico-radiologic criteria suggesting high-risk disease (TMH Criteria) from January 2010 to February 2016. RESULTS: On initial assessment, 140 (87...
April 26, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29693707/c%C3%A2-jun-suppresses-the-expression-of-wnt-inhibitory-factor-1-through-transcriptional-regulation-and-interaction-with-dna-methyltransferase-1-in-gallbladder-cancer
#16
Bin Lin, Haijie Hong, Xiaojie Jiang, Chengzong Li, Siyuan Zhu, Nanhong Tang, Xiaoqian Wang, Feifei She, Yanling Chen
WNT inhibitory factor 1 (WIF‑1) is involved in the tumorigenicity and progression of several types of tumor, which has been attributed to aberrant hypermethylation of its promoter. However, the role of WIF‑1 in the pathogenesis of gallbladder cancer (GBC) remains to be fully elucidated, and the data available are insufficient to identify the upstream molecular mechanisms involved. In the present study, the methylation status of the WIF‑1 promoter was investigated using methylation‑specific polymerase chain reaction (PCR) and bisulfate sequencing PCR in GBC cells...
April 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29693356/metagenomics-of-microbial-communities-in-gallbladder-bile-from-patients-with-gallbladder-cancer-or-cholelithiasis
#17
Yasuo Tsuchiya, Ernest Loza, Guido Villa-Gomez, Carlos C Trujillo, Sergio Baez, Takao Asai, Toshikazu Ikoma, Kazuo Endoh, Kazutoshi Nakamura
Salmonella typhi and Helicobacter infections have been shown to increase risk of gallbladder cancer (GBC), but findings have been inconsistent. Other bacterial infections may also be associated with GBC. However, information on microbial pathogens in gallbladder bile of GBC patients is scarce. We aimed to investigate the microbial communities in gallbladder bile of patients with GBC and cholelithiasis (CL). Seven GBC patients and 30 CL patients were enrolled in this study. Genomic DNA was extracted from bile and the V3-V4 region of 16S rRNA was amplified...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29685046/a-retrospective-analysis-of-patients-with-gallbladder-cancer-surgical-treatment-and-survival-according-to-tumor-stage
#18
Iago Justo, Alberto Marcacuzco, Oana-Anisa Nutu, Alejandro Manrique, Jorge Calvo, Óscar Caso, Félix Cambra, Álvaro García-Sesma, Luis Carlos Jiménez-Romero
INTRODUCTION: gallbladder cancer is the most common biliary neoplasm and the sixth most common tumor of the digestive system. The disease has an ominous prognosis, with a 5-year survival rate of approximately 5%. It is usually diagnosed late and surgical resection is the only potential cure. METHODS: a retrospective study was carried out in 92 patients with a pathological diagnosis of gallbladder cancer from January 2000 to January 2016. RESULTS: the mean age of cases was 72 ± 11 years; 64 subjects were females and 28 were males...
April 24, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29679780/diagnostic-accuracy-of-mdct-in-differentiating-gallbladder-cancer-from-acute-and-xanthogranulomatous-cholecystitis
#19
Ashish P Wasnik, Mathew S Davenport, Ravi K Kaza, William J Weadock, Aaron Udager, Nahid Keshavarzi, Bin Nan, Katherine E Maturen
OBJECTIVE: To determine the diagnostic accuracy of multi-detector CT (MDCT) for differentiating gallbladder cancer from acute and xanthogranulomatous cholecystitis using previously described imaging features. METHODS: In this IRB approved HIPAA-compliant retrospective cohort study, contrast-enhanced MDCT of histologically confirmed acute cholecystitis (n = 17), xanthogranulomatous cholecystitis (n = 25), and gallbladder cancer (n = 18) were reviewed independently by three abdominal radiologists blinded to outcome...
April 14, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29671891/the-association-of-circulating-inflammation-proteins-and-gallstone-disease
#20
Zhiwei Liu, Troy J Kemp, Yu-Tang Gao, Amanda Corbel, Emma E McGee, Bingsheng Wang, Ming-Chang Shen, Asif Rashid, Ann W Hsing, Allan Hildesheim, Ruth M Pfeiffer, Ligia A Pinto, Jill Koshiol
BACKGROUND: Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones. METHODS: We measured 13 cytokines (including 10 interleukins), that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. We estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders...
April 19, 2018: Journal of Gastroenterology and Hepatology
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