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https://www.readbyqxmd.com/read/29913534/effects-of-acute-stress-on-thrombosis
#1
Ohad S Bentur, Galit Sarig, Benjamin Brenner, Giris Jacob
Stress, the nonspecific response to any demand for change, is an adaptive response of the human body to various stimulants. As such, stress-induced hypercoagulation may represent an adaptive response to bleeding. Numerous epidemiological studies have revealed that a correlation exists between stress and thrombotic risk and biochemically, links of the relationship between psychological stress and coagulation pathways have been made. The stress reaction is coupled with neurohormonal changes mediated mainly by the sympathetic neural system and the hypothalamic-pituitary-adrenal axis...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#2
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29913414/effect-of-%C3%AE-adrenergic-receptor-agents-on-cardiac-structure-and-function-and-whole-body-gene-expression-in-daphnia-magna
#3
Tae-Yong Jeong, Jana Asselman, Karel A C De Schamphelaere, Filip Van Nieuwerburgh, Dieter Deforce, Sang Don Kim
Propranolol (PRO), a human β-AR (β-adrenergic receptor) antagonist, is considered to result in specific effects in a non-target species, D. magna, based on our previous studies. The present study investigated the effects of β-AR agents, including an antagonist and agonist using pharmacologically relevant endpoints as well as a more holistic gene expression approach to reveal the impacts and potential mode of actions (MOAs) in the model non-target species. Results show that the responses in cardiac endpoints and gene expression in D...
June 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29913411/evaluation-of-coordination-hysteresis-in-a-multidimensional-movement-task-with-continuous-relative-phase-and-self-organizing-maps
#4
Ben Serrien, Naaike Verhaeghe, Silke Verhaeghe, Bruno Tassignon, Jean-Pierre Baeyens
Hysteresis in the coordination of movement can be described in the language of coordination dynamics as an asymmetrical response of a system's order parameter with respect to opposite changes in a control parameter. For movement tasks involving a large number of active degrees-of-freedom, the order parameter can be modelled with a pattern recognition approach like Self-Organizing Maps (SOM). This study explored this method in a rope-skipping task, which involves the coordinated oscillation of several segments in the lower and upper limb and trunk and we compared the results to a classical order parameter like continuous relative phase...
June 15, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29913354/benefits-of-an-increased-prosthetic-ankle-range-of-motion-for-individuals-with-a-trans-tibial-amputation-walking-with-a-new-prosthetic-foot
#5
Daniel W W Heitzmann, Firooz Salami, Alan R De Asha, Julia Block, Cornelia Putz, Sebastian I Wolf, Merkur Alimusaj
BACKGROUND: Individuals with trans-tibial amputation show a greater peak prosthetic ankle power (push- off) when using energy storing and returning (ESAR) prosthetic feet as compared to solid-ankle cushion-heel feet. ESAR feet further contribute to the users' body support and thus limit prosthetic ankle motion. To improve ankle motion, articulating prosthetic feet have been introduced. However, articulating feet may diminish push-off. RESEARCH QUESTION: Does a novel prosthetic foot, with a serial layout of carbon fibre leaf springs, connected by a multi-centre joint construction, have advantages in kinematics and kinetics over a conventional ESAR prosthetic foot?> METHODS: Eleven individuals with unilateral trans-tibial amputation were fitted with the novel foot (NF) and a conventional ESAR Foot (CF) and underwent 3D gait analysis...
June 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29913309/the-causes-and-consequences-of-variation-in-human-cytokine-production-in-health
#6
REVIEW
Melanie Schirmer, Vinod Kumar, Mihai G Netea, Ramnik J Xavier
Cytokines are important cell-signaling molecules that activate and modulate immune responses. Major factors influencing cytokine variation in healthy individuals are host genetics, non-heritable factors and the microbiome. Genetic variation accounts for a significant part of heterogeneity in cytokine production by peripheral blood mononuclear cells. Variation in cytokines such as IL-6 and IL-6Ra is strongly influenced by heritability, suggesting an evolutionarily pressure for their genetic regulation that potentially contributes to differences in immune responsiveness between human populations...
June 15, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29913290/non-fusion-intracorporeal-enhancement-system-for-the-treatment-of-osteoporotic-vertebral-compression-fractures-preliminary-clinical-result-of-a-novel-technique
#7
Jingchuan Sun, Qingjie Kong, Yong Yang, Jiangang Shi, Yang Hou, Ximing Xu, Yuan Wang, Haisong Yang, Yongfei Guo, Guodong Shi, Yingjie Wang, Peng Zhang
PURPOSE: This study is to determine whether implantation of a newly designed non-fusion intracorporeal enhancement (NICE) system is an effective and a safe way for the treatment of osteoporotic vertebral compression fracture (OVCF). METHODS: 13 OVCF patients (10 women, 3 men, mean age 69, T11 to L4) were included. From June 2014 to June 2016 all of them were treated with the NICE system. The clinical and radiological results were both evaluated preoperatively, postoperatively, 24 months follow-up based on the visual analog scale (VAS) and the Oswestry Disability Index (ODI), X-ray, MRI and CT (Height of fractured body and kyphosis Cobb angle)...
June 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29913275/rates-and-factors-associated-with-placebo-response-in-trials-of-pharmacotherapies-for-nonalcoholic-steatohepatitis-systematic-review-and-meta-analysis
#8
REVIEW
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Ohad Etzion, Eric Lefebvre, Rifaat Safadi, Vlad Ratziu, Larry J Prokop, Mohammad Hassan Murad, Mazen Noureddin
BACKGROUND & AIMS: Understanding the extent of the placebo effect in randomized controlled trials of studying nonalcoholic steatohepatitis (NASH) is important for optimal trial design, including sample size calculations and treatment endpoint definition. METHODS: We performed a systematic review and meta-analysis of the placebo groups from randomized controlled trials of adults with NASH that provided histological and/or magnetic resonance image-based measurements of intrahepatic triglyceride...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29913240/detection-of-19-bp-deletion-within-plag1-gene-and-its-effect-on-growth-traits-in-cattle
#9
Wei Xu, Hua He, Li Zheng, Jia-Wei Xu, Chu-Zhao Lei, Gui-Min Zhang, Rui-Hua Dang, Hui Niu, Xing-Lei Qi, Hong Chen, Yong-Zhen Huang
Polymorphic adenoma gene 1 (PLAG1) is a member of the pleomorphic adenoma gene family. PLAG family of proteins as a nuclear transcription factor mainly play a role in regulating a variety of important genes in the body. The aim of this study was to examine the association of the PLAG1 polymorphism with growth traits in 566 cattle. A novel 19-bp indel mutation was identified in the PLAG1 by sequencing pooled DNA samples (Pool-Seq) and agarose gel electrophoresis methods. The PCR products of PLAG1 exhibited 3 genotypes and 2 alleles: 142 bp (denoted as W) and 123 bp (denoted as D)...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29913228/effects-of-prenatal-exposure-to-cigarettes-on-anthropometrics-energy-intake-energy-expenditure-and-screen-time-in-children
#10
Jameason D Cameron, Éric Doucet, Kristi B Adamo, Mark Walker, Alessandro Tirelli, Joel D Barnes, Kaamel Hafizi, Marisa Murray, Gary S Goldfield
BACKGROUND: Maternal prenatal smoking is associated with downstream childhood obesity. Although animal research suggests reduced resting energy expenditure (REE), decreased physical activity (PA), and increased energy intake as mechanisms, these relationships are unclear in humans. The objectives were to examine the association of prenatal maternal smoking with non-volitional energy expenditure (REE and the thermic effect of feeding [TEF]), child adiposity, energy intake, free-living PA (daily light PA (LPA), daily moderate-to-vigorous PA (MVPA), daily sedentary behavior (SB)), and screen time (television and computer/video game) in children...
June 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29913226/evaluating-anhedonia-in-the-activity-based-anorexia-aba-rat-model
#11
Laura K Milton, Brian J Oldfield, Claire J Foldi
Patients suffering anorexia nervosa (AN) become anhedonic, in other words, unable or unwilling to derive normal pleasures and avoid rewarding outcomes, most profoundly in food intake. The neurobiological underpinnings of anhedonia are likely to involve mesolimbic reward circuitry. We propose here that this circuitry and its involvement in AN can be investigated using the activity-based anorexia (ABA) rodent model that recapitulates many of the characteristics of the human condition, most notably rapid weight loss...
June 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29913222/a-multifunctional-multimaterial-system-for-on-demand-protein-release
#12
REVIEW
Deniz Ceylan Tuncaboylu, Fabian Friess, Christian Wischke, Andreas Lendlein
In order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29913218/practical-aspects-in-size-and-morphology-characterization-of-drug-loaded-nano-liposomes
#13
Sivan Peretz Damari, Dima Shamrakov, Maxim Varenik, Erez Koren, Einat Nativ-Roth, Yechezkel Barenholz, Oren Regev
Size and morphology distributions are critical to the performance of nano-drug systems, as they determine drug pharmacokinetics and biodistribution. Therefore, comprehensive and reliable analyses of these properties are required by both the US Food and Drug Administration (FDA) and European Medicines Agency (EMA). In this study, we compared two most commonly used approaches for assessing the size distribution and morphology of liposomal nano-drug systems, namely, dynamic light scattering (DLS) and cryogenic-transmission electron microscopy (cryo-TEM); an automated quantitative analysis method was developed for the latter method...
June 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29913217/detailed-analysis-of-the-prothoracic-tissues-transforming-into-wings-in-the-cephalothorax-mutants-of-tribolium
#14
Courtney M Clark-Hachtel, Madison R Moe, Yoshinori Tomoyasu
Despite the immense importance of the wing in the evolution and successful radiation of the insect lineages, the origin of this critical structure remains a hotly-debated mystery. Two possible tissues have been identified as an evolutionary origin of wings; the lateral expansion of the dorsal body wall (tergal edge) and structures related to an ancestral proximal leg segment (pleural tissues). Through studying wing-related tissues in the red flour beetle, Tribolium castaneum, we have previously presented evidence in support of a dual origin of insect wings, a third hypothesis proposing that wings evolved from a combination of both tergal and pleural tissues...
June 15, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29913203/frontal-eeg-asymmetry-moderates-the-association-between-attentional-bias-towards-food-and-body-mass-index
#15
Laura McGeown, Ron Davis
High global incidence of obesity has led to efforts to identify factors that may contribute to elevated body mass index (BMI). Studies have shown individuals with obesity tend to display an attentional bias (AB) towards food. Left frontal EEG alpha asymmetry (FA) has been associated with motivation to approach rewards and may heighten reactivity to food cues. The current study thus explored whether the association between AB to food and BMI is moderated by FA. EEG was recorded while 93 female participants watched a video confederate incidentally consume potato chips...
June 15, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29913176/local-delivery-of-adenosine-receptor-agonists-to-promote-bone-regeneration-and-defect-healing
#16
Christopher D Lopez, Jonathan M Bekisz, Carmen Corciulo, Aranzazu Mediero, Paulo G Coelho, Lukasz Witek, Roberto L Flores, Bruce N Cronstein
Adenosine receptor activation has been investigated as a potential therapeutic approach to heal bone. Bone has enhanced regenerative potential when influenced by either direct or indirect adenosine receptor agonism. As investigators continue to elucidate how adenosine influences bone cell homeostasis at the cellular and molecular levels, a small but growing body of literature has reported successful in vivo applications of adenosine delivery. This review summarizes the role adenosine receptor ligation plays in osteoblast and osteoclast biology and remodeling/regeneration...
June 15, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29913132/a-novel-kinematics-analysis-method-using-quaternion-interpolation-a-case-study-in-frog-jumping
#17
Christopher T Richards, Laura B Porro
Spherical Linear Interpolation (SLERP) has long been used in computer animation to interpolate movements between two 3D orientations. We developed a forward kinematics (FK) approach using quaternions and SLERP to predict how frogs modulate jump kinematics between start posture and takeoff. Frog limb kinematics have been studied during various activities, yet the causal link between differences in joint kinematics and locomotor variation remains unknown. We varied 1) takeoff angle from 8 to 60 degrees; 2) turn angle from 0 to 18 degrees; and 3) initial body pitch from 0 to 70 degrees...
June 15, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29913127/rosai-dorfman-disease-masquerading-as-uveal-melanoma-case-report-and-review-of-literature
#18
Yacoub A Yousef, Maysa Al-Hussaini, Rashed Nazzal, Ghadeer Abdeen, Ibrahim Alnawaiseh, Khaleel Alrawashdeh
OBJECTIVE/BACKGROUND: Intra ocular Rosai-Dorfman disease (RDD) is an extremely rare disease. We are reporting the first case of RDD presenting as ciliary body mass mimicking ciliary body melanoma, and we are reviewing the English literature reporting on cases of RDD presented with intraocular disease. METHODS: An 18-year-old lady presented with loss of vision in the right eye, and was found to have intraocular mass lesion. She was diagnosed clinically and radiologically as a case of ciliary body melanoma associated with total retinal detachment...
June 15, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29913097/age-and-maturity-related-differences-in-motor-coordination-among-male-elite-youth-soccer-players
#19
Nikki Rommers, Mireille Mostaert, Lennert Goossens, Roel Vaeyens, Erik Witvrouw, Matthieu Lenoir, Eva D'Hondt
This study investigated differences in generic and soccer specific motor coordination, as well as speed and agility depending on age and maturity in elite youth soccer players (U10-U15, N = 619). Measurements included body height, body weight and sitting height to estimate age at peak height velocity (APHV); three Körperkoordinationstest für Kinder subtests (i.e. jumping sideways (JS), moving sideways (MS), balancing backwards (BB)) to assess generic motor coordination; the UGent dribbling test for soccer specific motor coordination; a 5m/30m sprint and T-test for speed and agility, respectively...
June 18, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29913081/anxiety-management-participants-experiences-of-a-physiotherapeutic-group-treatment-in-swedish-psychiatric-outpatient-care
#20
Helena Ölund, Louise Danielsson, Susanne Rosberg
Anxiety disorders are among the most persistent mental health syndromes. There is extensive research showing effectiveness of pharmacotherapy and psychotherapy interventions targeting anxiety, while knowledge is still sparse for other treatment options. The aim of this study was to explore how participants with anxiety disorders experience a physiotherapeutic group treatment in psychiatric outpatient care, and their perceived ability to manage anxiety within two months after participating in the treatment. Semi-structured interviews with participants were conducted to explore experiences of the treatment...
June 18, 2018: Physiotherapy Theory and Practice
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