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https://www.readbyqxmd.com/read/28437975/experimental-demonstration-of-efficient-quantum-state-tomography-of-matrix-product-states
#1
Yuan-Yuan Zhao, Zhibo Hou, Guo-Yong Xiang, Yong-Jian Han, Chuan-Feng Li, Guang-Can Guo
Quantum state tomography is a key technology for fully determining a quantum state. Unfortunately, standard quantum state tomography is intractable for general many-body quantum states, because the number of measurements and the post-processing time increase exponentially with the size of the system. However, for the matrix product states (MPSs), there exists an efficient method using linearly scaled local measurements and polynomially scaled post-processing times. In this study, we demonstrate the validity of the method in practice by reconstructing a four-photon MPS from its local two- or three-photon reduced-density matrices with the presence of statistical errors and systematical errors in experiment...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437889/safety-of-sucrose-esters-from-physalis-peruviana-l-in-a-28-day-repeated-dose-study-in-mice
#2
Yanet C Ocampo, Daneiva C Caro, David E Rivera, Luis A Franco
Although extracts and consumed foods from Physalis species contain sucrose esters from their glandular trichomes, there is no experimental data available on their toxicological effects. As peruvioses A and B isolated from Physalis peruviana L. calyces have proved to be effective anti-inflammatory and immunomodulatory compounds, this work aimed to investigate their sub-acute toxicity study and genotoxicity. For this, CD-1(ICR) mice were treated intraperitoneally with peruvioses at doses of 2.5, 5, and 10mg/kg/day for 28 consecutive days, to simulate therapeutic and over-therapeutic dosage levels...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437852/a-diagnostic-microdosing-approach-to-investigate-platinum-sensitivity-in-non-small-cell-lung-cancer
#3
Si-Si Wang, Maike Zimmermann, Hongyong Zhang, Tzu-Yin Lin, Michael Malfatti, Kurt Haack, Kenneth W Turteltaub, George D Cimino, Ralph de Vere White, Chong-Xian Pan, Paul T Henderson
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are often used for chemotherapy, but drug resistance is common. The prediction of resistance to these drugs via genomics is a challenging problem since hundreds of genes are involved. A possible alternative is to use mass spectrometry to determine the propensity for cells to form drug-DNA adducts-the pharmacodynamic drug-target complex for this class of drugs. The feasibility of predictive diagnostic microdosing was assessed in non-small cell lung cancer (NSCLC) cell culture and a pilot clinical trial...
April 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28437841/characterizing-the-evolution-of-wide-gauge-features-in-stylopodial-limb-elements-of-titanosauriform-sauropods-via-geometric-morphometrics
#4
Paul V Ullmann, Matthew F Bonnan, Kenneth J Lacovara
Wide-gauge posture of titanosauriform sauropods remains an enigmatic peculiarity among terrestrial vertebrates. Here, two-dimensional geometric morphometrics and thin plate splines analyses were used to quantitatively analyze shape differences among sauropodomorph humeri and femora to identify how these elements may differ according to body gauge. Results demonstrate that titanosauriforms generally possess proportionately gracile humeri in comparison to other sauropods, with relatively more medially oriented humeral heads and proximally located deltopectoral crests...
April 24, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28437834/elucidation-of-factor-viii-activity-pharmacokinetics-a-pooled-population-analysis-in-hemophilia-a-patients-treated-with-moroctocog-alfa
#5
João A Abrantes, Elisabet I Nielsen, Joan Korth-Bradley, Lutz Harnisch, Siv Jönsson
This study investigated the disposition of coagulation factor VIII activity in 754 moderate to severe hemophilia A patients following the administration of moroctocog alfa, a B-domain deleted recombinant factor VIII. Data analyzed included patients aged 1 day to 73 years enrolled in 13 studies conducted over a period of 20 years in 25 countries. A two-compartment population pharmacokinetic model with a baseline model described the pooled data well. Body size, age, inhibitors, race and analytical assay were identified as significant predictors of factor VIII disposition...
April 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28437812/infection-rate-in-1033-elective-neurosurgical-procedures-at-a-university-hospital-in-south-china
#6
Hongwei Zhu, Xiyao Liu, Zhanxiang Wang
Objective Infection following surgery is a serious complication, especially in neurosurgery. The aim of the study is to report the change of incidence rates of infection in patients undergoing elective neurosurgical procedures at a university hospital in South China as well as the risk factors. Material and Methods The medical records and postoperative courses for patients undergoing 1,033 neurosurgical procedures from 2008 to 2014 were reviewed retrospectively to determine the incidence of neurosurgical infection, the identity of the offending organisms, and the factors associated with infection...
April 24, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28437785/the-retina-of-asian-and-african-elephants-comparison-of-newborn-and-adult
#7
Heidrun Kuhrt, Andreas Bringmann, Wolfgang Härtig, Gudrun Wibbelt, Leo Peichl, Andreas Reichenbach
Elephants are precocial mammals that are relatively mature as newborns and mobile shortly after birth. To determine whether the retina of newborn elephants is capable of supporting the mobility of elephant calves, we compared the retinal structures of 2 newborn elephants (1 African and 1 Asian) and 2 adult animals of both species by immunohistochemical and morphometric methods. For the first time, we present here a comprehensive qualitative and quantitative characterization of the cellular composition of the newborn and the adult retinas of 2 elephant species...
April 25, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28437722/effective-active-vaccination-against-methamphetamine-in-female-rats
#8
J D Nguyen, P T Bremer, C S Hwang, S A Vandewater, K C Collins, K M Creehan, K D Janda, M A Taffe
BACKGROUND: Immunotherapies directed against methamphetamine (MA) abuse have shown success in rodent models, however only a limited number of studies have investigated active vaccination in female mice and none in female rats. It is critical to determine if potential immunotherapeutic strategies generalize across sex, particularly for drugs that may produce significant sex-differences on behavioral or physiological endpoints. METHODS: Female Wistar rats were initially vaccinated with keyhole-limpet hemocyanin (KLH) or an anti-methamphetamine-KLH conjugate (MH6-KLH) three times over five weeks and implanted with radiotelemetry devices to assess locomotor activity and body temperature responses to MA...
April 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28437687/use-of-tourmaline-as-a-potential-petrogenetic-indicator-in-the-determination-of-host-magma-crs-xrd-and-ped-xrf-methods
#9
Bahattin Gullu, Yusuf Kagan Kadioglu
Tourmaline defines a group of complex borosilicate forms as accessory mineral in igneous and metamorphic rocks and they act an important role in the interpretation of the chemical composition changes of the composition of the host fluid of the magma. The variety of tourmaline can be identified by using optical microscopy, X-Ray Diffraction (XRD) and by determining its chemical composition through Polarized Energy Dispersive X-Ray Fluorescence (PED-XRF) methods. However, microscopic investigations and XRD analyses are not quite adequate for detailed determination of tourmaline sub-groups...
April 19, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28437679/nodal-recurrence-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-incidence-and-proposed-risk-factors
#10
REVIEW
Krista C J Wink, Angela van Baardwijk, Esther G C Troost, Dirk De Ruysscher
Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with endobronchial ultrasound and/or mediastinoscopy, and typically undergo intra-operative lymph node dissection or sampling...
April 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28437649/occurrences-and-removal-of-pharmaceuticals-and-personal-care-products-ppcps-in-drinking-water-and-water-sewage-treatment-plants-a-review
#11
REVIEW
Yi Yang, Yong Sik Ok, Ki-Hyun Kim, Eilhann E Kwon, Yiu Fai Tsang
In recent years, many of micropollutants have been widely detected because of continuous input of pharmaceuticals and personal care products (PPCPs) into the environment and newly developed state-of-the-art analytical methods. PPCP residues are frequently detected in drinking water sources, sewage treatment plants (STPs), and water treatment plants (WTPs) due to their universal consumption, low human metabolic capability, and improper disposal. When partially metabolized PPCPs are transferred into STPs, they elicit negative effects on biological treatment processes; therefore, conventional STPs are insufficient when it comes to PPCP removal...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437638/motor-expertise-and-performance-in-spatial-tasks-a-meta-analysis
#12
Daniel Voyer, Petra Jansen
The present study aimed to provide a summary of findings relevant to the influence of motor expertise on performance in spatial tasks and to examine potential moderators of this effect. Studies of relevance were those in which individuals involved in activities presumed to require motor expertise were compared to non-experts in such activities. A final set of 62 effect sizes from 33 samples was included in a multilevel meta-analysis. The results showed an overall advantage in favor of motor experts in spatial tasks (d=0...
April 21, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#13
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437610/long-acting-release-formulation-of-exendin-4-based-on-biomimetic-mineralization-for-type-2-diabetes-therapy
#14
Wei Chen, Guohao Wang, Bryant C Yung, Gang Liu, Zhiyong Qian, Xiaoyuan Chen
Exendin-4 has been clinically exploited for treating type 2 diabetes, but the short circulation half-life and multiple daily injections limit its widespread application with respect to poor patient compliance, low efficacy, and high treatment cost. In this study, a potent long-acting release system based on biomimetic mineralization was constructed for biocompatible and sustained exendin-4 delivery. Similar to natural biomineralization, exendin-4 can be mineralized to form nano-sized mineral solids by means of the reaction between acidic amino acid residues and calcium ions in a supersaturated environment with negligible influence on peptide bioactivity...
April 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28437601/maternal-hemodynamics-in-normal-pregnancies-reference-ranges-and-the-role-of-maternal-characteristics
#15
Dimuthu Vinayagam, Baskaran Thilaganathan, Oliver Stirrup, Elena Mantovani, Asma Khalil
OBJECTIVES: The main aim of this study was to construct reference ranges of the maternal central hemodynamic parameters during pregnancy. The second aim was to determine the maternal and pregnancy characteristics, which influence these hemodynamic parameters. METHODS: This was a prospective cohort study of low-risk pregnant women attending for routine antenatal care at St George's Hospital, London. The exclusion criteria included any medical disorder present at the time of study recruitment, or development of hypertension or intrauterine fetal growth restriction following study recruitment...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28437585/chronic-intestinal-electrical-stimulation-improves-glucose-intolerance-and-insulin-resistance-in-diet-induced-obesity-rats
#16
Shiying Li, Weijian Zhu, Sujuan Zhang, Jiande Dz Chen
OBJECTIVE: Obesity is a contributing factor to insulin resistance and type 2 diabetes. The aim of this study was to study the therapeutic potential of intestinal electrical stimulation (IES) for obesity and associated glucose intolerance and insulin resistance in diet-induced obesity (DIO) rats. METHODS: DIO rats were divided into two groups to receive sham or IES for 8 weeks. Oral glucose tolerance and insulin tolerance tests were performed. Gastric emptying and small bowel transit tests were performed...
April 24, 2017: Obesity
https://www.readbyqxmd.com/read/28437574/dietary-lactalbumin-and-lactoferrin-interact-with-inulin-to-modulate-energy-balance-in-obese-rats
#17
Arashdeep Singh, Rizaldy C Zapata, Adel Pezeshki, Prasanth K Chelikani
OBJECTIVE: To determine whether diets enriched with the whey protein components lactalbumin and lactoferrin interact additively with inulin to improve energy balance by decreasing food intake and body weight (BW). METHODS: In four experiments, diet-induced obese rats were randomized to diets containing either lactalbumin or lactoferrin at low (20% kcal) or high (40% kcal) doses, and inulin at low (7.5% w/w) or high (15% w/w) doses, alone or in combination. Energy intake (EI), energy expenditure (EE), respiratory quotient (RQ), BW, body composition, plasma insulin, and leptin concentrations were measured...
April 24, 2017: Obesity
https://www.readbyqxmd.com/read/28437565/relaxed-ordered-subset-preconditioned-alternating-projection-algorithm-for-pet-reconstruction-with-automated-penalty-weight-selection
#18
C Ross Schmidtlein, Yizun Lin, Si Li, Andrzej Krol, Bradley J Beattie, John L Humm, Yuesheng Xu
PURPOSE: Performance of the preconditioned alternating projection algorithm (PAPA) using relaxed ordered subsets (ROS) with a non-smooth penalty function was investigated in positron emission tomography (PET). A higher order total variation (HOTV) regularizer was applied and a method for unsupervised selection of penalty weights based on the measured data is introduced. METHODS: A ROS version of PAPA with HOTV penalty (ROS-HOTV-PAPA) for PET image reconstruction was developed and implemented...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28437555/polymorphisms-of-alui-and-hin1i-loci-of-the-igf-1r-gene-and-their-genetic-effects-on-growth-traits-in-bian-chickens
#19
P F Wu, D Wang, C F Jin, X Q Zhang, H Q Wu, L Zhang, F X Ding, K Z Xie, G X Zhang
Growth traits are important economic traits in broiler chicken production. AluI and Hin1I loci are two restriction sites, which are respectively located in exons 2 and 3 of the IGF-1R gene. These two loci are significantly related to the growth traits in Jinghai Yellow chickens. In this study, a correlation analysis was performed between these two loci and the growth traits of Bian chickens. The results showed a G376A mutation at the AluI site and a C919A mutation at the Hin1I site, which respectively resulted in three genotypes AA, AB, and BB in exon 2 and three genotypes CC, CD, and DD in exon 3...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28437554/molecular-identification-of-cetaceans-from-the-west-atlantic-using-the-e3-i5-region-of-coi
#20
L H O Falcão, A S Campos, J E P Freitas, M A A Furtado-Neto, V V Faria
Molecular identification is very useful in cases where morphology-based species identification is not possible. Examples for its application in cetaceans include the identification of carcasses of stranded animals in advanced state of decomposition and body parts that are illegally traded. One DNA region that is often used for molecular identification is the Folmer region of the mitochondrial gene cytochrome c oxidase subunit I (COI) (locus 48 to 705 bp). This locus has been used for the identification of several animal species, including whales and dolphins...
April 20, 2017: Genetics and Molecular Research: GMR
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