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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/28930695/metabolomics-assessment-of-the-effects-of-diclofenac-exposure-on-mytilus-galloprovincialis-potential-effects-on-osmoregulation-and-reproduction
#2
Bénilde Bonnefille, Elena Gomez, Mellis Alali, David Rosain, Hélène Fenet, Frédérique Courant
The presence of pharmaceutically active compounds in aquatic environments has become a major concern over the past 20years. Elucidation of their mode of action and effects in non-target organisms is thus now a major ecotoxicological challenge. Diclofenac (DCF) is among the pharmaceutical compounds of interest based on its inclusion in the European Union Water Framework Directive Watch List. In this study, our goal was to investigate the potential of a metabolomic approach to acquire information without any a priori hypothesis about diclofenac effects on marine mussels...
September 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28929840/leaders-go-first-creating-and-sustaining-a-culture-of-high-performance
#3
Bonnie S Cochrane
The culture of a healthcare organization plays a critically important role in determining whether strategic plans will be executed effectively and organizational goals will be achieved. A culture of high performance serves as a foundation that supports the implementation of healthcare strategies and enables health leaders to evaluate, select, optimize, and sustain a full portfolio of improvement initiatives linked directly to top priorities and mandates. This article argues that a culture of high performance should become an integral part of all strategic planning and, further, that a strong and explicit leadership commitment, beginning with the board and CEO and extending throughout all leadership levels, is required to implement a successful culture transformation...
September 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929171/-impact-of-european-e-commerce-liberalisation-on-pharmaceutical-crime-the-alpha-research-project
#4
REVIEW
Arndt Sinn
The trading of illicit and falsified pharmaceuticals is a growth market. Factors influencing this illegal market are high profit margins, a low risk of detection, low control density, an obscure legal situation, and lastly, the easy and anonymous ways of selling over the Internet, usually across national borders. This situation was the background for the research project on the impact of European e‑commerce liberalisation on pharmaceutical crime (ALPhA). The goal of the project was to develop concrete recommendations for action regarding the improved prosecution of internet-based pharmaceutical crime and to create a broad body of data for effective law-making by legislators...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28929064/efficacy-of-trt-using-noise-presentation-from-mobile-phone
#5
Md Noorain Alam, Manish Gupta, Sanjay Munjal, Naresh K Panda
The purpose of tinnitus retraining therapy (TRT) is to induce habituation, first of the reaction to the tinnitus signal, and subsequently to habituate the perception of tinnitus itself. Habituation of sound is achieved through sound treatment which involves the use of low-level broadband noise mainly through noise maskers. Noise maskers are costly hence there is a need to find an alternate source of noise like MP3 and mobile phones. The goal of present study was to find out whether persons with tinnitus may be successfully treated with TRT using sound treatment from the noise presented through mobile phones...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28928026/an-online-resource-to-promote-vocational-interests-among-job-seekers-with-multiple-sclerosis-a-randomized-controlled-trial-in-australia
#6
Diana Dorstyn, Rachel Roberts, Gregory Murphy, Ian Kneebone, Ashley Craig, Christine Migliorini
OBJECTIVE: To provide a preliminary evaluation of the effectiveness of an on-line resource for job-seekers with multiple sclerosis. DESIGN: Randomized controlled design. SETTING: Community-dwelling cohort in Australia. PARTICIPANTS: Forty-seven adults with relapsing-remitting or progressive MS accessed an email-delivered, 7-module resource - 'Work and MS' - over a 4-week period. Fifty wait-list control participants were offered the opportunity to access 'Work and MS' 4 weeks post-enrolment...
September 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28927773/-school-refusal-psychopathological-profiles-of-adolescents-followed-in-a-day-hospital-setting
#7
J Romani, S Campredon, D Da Fonseca
INTRODUCTION: School refusal appeared when formal education became compulsory in 1882, with the Jules Ferry laws. In international psychiatric classifications, school refusal does not appear as a diagnosis by itself, but it co-exists and is inherent to the symptoms of other psychiatric conditions, in particular of anxiety and depressive disorders. The main goal of this study was to describe psychopathological disorders in teenagers presenting school refusal followed in a day hospital setting...
September 15, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28927560/patient-variation-limits-use-of-fixed-references-for-femoral-rotation-component-alignment-in-total-knee-arthroplasty
#8
Joshua G Twiggs, David M Dickison, Elizabeth C Kolos, Caitlin E Wilcox, Justin P Roe, Brett A Fritsch, Stephen J McMahon, Brad P Miles, Andrew J Ruys
BACKGROUND: Optimal rotational alignment of the femoral component is a common goal during total knee arthroplasty. The posterior condylar axis (PCA) is thought to be the most reproducible reference in surgery, while the transepicondylar axis (TEA) seems to better approximate the native kinematic flexion axis. This study sought to determine if rules based on patient gender or coronal alignment could allow reliable reproduction of the TEA from the PCA. METHODS: Three-dimensional models based on preoperative computed tomography were made representing a patient's arthritic knee joint...
August 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28926357/first-in-human-treatment-with-a-dendritic-cell-targeting-lentiviral-vector-expressing-ny-eso-1-lv305-induces-deep-durable-response-in-refractory-metastatic-synovial-sarcoma-patient
#9
Seth M Pollack, Hailing Lu, Sacha Gnjatic, Neeta Somaiah, Ryan B O'Malley, Robin L Jones, Frank J Hsu, Jan Ter Meulen
Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1...
September 18, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28926286/training-behavioral-control-in-adolescents-using-a-serious-game
#10
Wouter J Boendermaker, Remco C Veltkamp, Margot Peeters
OBJECTIVE: Risk taking, such as heavy alcohol use, is commonplace among adolescents. Nevertheless, prolonged alcohol use at this age can lead to severe health problems. The goal of this study was to develop and evaluate a serious game training ("The Fling"), aimed at increasing behavioral control in adolescents and thereby helping them to improve control over their alcohol use. The game training was compared to a game placebo and a nongame training version in a randomized controlled trial...
September 19, 2017: Games for Health
https://www.readbyqxmd.com/read/28924013/reward-related-ventral-striatum-activity-buffers-against-the-experience-of-depressive-symptoms-associated-with-sleep-disturbances
#11
Reut Avinun, Adam Nevo, Annchen R Knodt, Maxwell L Elliott, Spenser R Radtke, Bartholomew D Brigidi, Ahmad R Hariri
Sleep disturbances represent one risk factor for depression. Reward-related brain function, particularly the activity of the ventral striatum (VS), has been identified as a potential buffer against stress-related depression. We were therefore interested in testing whether reward-related VS activity would moderate the effect of sleep disturbances on depression in a large cohort of young adults. Data were available from 1129 university students (mean age 19.71 ± 1.25 years; 637 women) who completed a reward-related functional MRI task to assay VS activity and provided self-reports of sleep using the Pittsburgh Sleep Quality Index and symptoms of depression using a summation of the General Distress/Depression (GDD) and Anhedonic Depression (AD) subscales of the Mood and Anxiety Symptoms Questionnaire-short form...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28924006/the-neural-basis-of-aversive-pavlovian-guidance-during-planning
#12
Níall Lally, Quentin J M Huys, Neir Eshel, Paul Faulkner, Peter Dayan, Jonathan P Roiser
Important real-world decisions are often arduous as they frequently involve sequences of choices, with initial selections affecting future options. Evaluating every possible combination of choices is computationally intractable, particularly for longer multi-step decisions. Therefore, humans frequently employ heuristics to reduce the complexity of decisions. We recently used a goal-directed planning task to demonstrate the profound behavioral influence and ubiquity of one such shortcut, namely aversive pruning, a reflexive Pavlovian process that involves neglecting parts of the decision space residing beyond salient negative outcomes...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28923494/transformative-research-is-not-easily-predicted
#13
REVIEW
Sarah A Gravem, Silke M Bachhuber, Heather K Fulton-Bennett, Zachary H Randell, Alissa J Rickborn, Jenna M Sullivan, Bruce A Menge
Transformative research (TR) statements in scientific grant proposals have become mainstream. However, TR is defined as radically changing our understanding of a concept, causing a paradigm shift, or opening new frontiers. We argue that it is rarely possible to predict the transformative nature of research. Interviews and surveys of 78 transformative ecologists suggest that most TR began with incremental goals, while transformative potential was recognized later. Most respondents thought TR is unpredictable and should not be prioritized over 'incremental' research that typically leads to breakthroughs...
September 15, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28923479/neuralrepresentation-of-cost-benefit-selectionsin-medial-prefrontal-cortex-of-rats
#14
Hua Tang, Xuan Sun, Bao-Ming Li, Fei Luo
Decision making refers to the process that subjects use to choose between competing courses of action based on the expected costs and benefits of their consequences. However, few studies have addressed the neuronal mechanisms behind the processes of howcosts and benefits influence decision making. Here we investigated the neuronal representation of costs and benefitstowards a goal-directed action under a differential reward schedule by training rats to perform a "Do more, get more" (DM-GM) task utilizinga nosepoke operandum, where longer nosepoke durations resulted in correspondingly larger rewards...
September 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28922395/an-analysis-of-equine-round-pen-training-videos-posted-online-differences-between-amateur-and-professional-trainers
#15
Erin Kydd, Barbara Padalino, Cathrynne Henshall, Paul McGreevy
Natural Horsemanship is popular among many amateur and professional trainers and as such, has been the subject of recent scientific enquiry. One method commonly adopted by Natural Horsemanship (NH) trainers is that of round pen training (RPT). RPT sessions are usually split into a series of bouts; each including two phases: chasing/flight and chasing offset/flight offset. However, NH training styles are heterogeneous. This study investigated online videos of RPT to explore the characteristics of RPT sessions and test for differences in techniques and outcomes between amateurs and professionals (the latter being defined as those with accompanying online materials that promote clinics, merchandise or a service to the public)...
2017: PloS One
https://www.readbyqxmd.com/read/28920666/a-softoxometalate-k6-5cu-oh-8-5-h2o-7-5-0-5-k3pw12o40-n-n-1348-2024-as-an-efficient-inorganic-material-for-co2-reduction-with-concomitant-water-oxidation
#16
Santu Das, Saurabh Kumar, Somenath Garai, Ramudu Pochamoni, Shounik Paul, Soumyajit Roy
An immediate challenge for chemists is to devise different methods to trap chemical energy using light by reduction of carbon dioxide to a transportable fuel. To reach this goal the major obstacle lies in finding a suitable material that is abundant and possesses catalytic power to effect such reduction reaction and perform this reduction reaction without using any external photosensitizer. Here we report first time a softoxometalate, based on {[K6.5Cu(OH)8.5(H2O)7.5]0.5[K3PW12O40]} metal oxide framework which is stable in reaction condition that effectively performs photochemical CO2 reduction reaction in water with a very high turnover number of 613 and TOF of 47...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28919828/jugular-bulb-oxygen-saturation-correlates-with-full-outline-of-responsiveness-score-in-severe-traumatic-brain-injury-patients
#17
Tjokorda Gde Agung Senapathi, Made Wiryana, Ketut Sinardja, Ketut Wibawa Nada, Ida Bagus Krisna Jaya Sutawan, Christopher Ryalino, Aloysius Alphonso
BACKGROUND: Maintaining brain oxygenation status is the main goal of treatment in severe traumatic brain injury (TBI). Jugular venous oxygen saturation (SjvO2) monitoring is a technique to estimate global balance between cerebral oxygen supply and its metabolic requirement. Full Outline of Responsiveness (FOUR) score, a new consciousness measurement scoring, is expected to become an alternative for Glasgow Coma Scale (GCS) in evaluating neurologic status of patients with severe traumatic head injury, especially for those under mechanical ventilation...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28919717/the-influence-of-goal-directed-fluid-therapy-on-the-prognosis-of-elderly-patients-with-hypertension-and-gastric-cancer-surgery-retraction
#18
(no author information available yet)
[This retracts the article on p. 2113 in vol. 8.].
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28918907/thioredoxin-promotes-survival-signaling-events-under-nitrosative-oxidative-stress-associated-with-cancer-development
#19
REVIEW
Hugo P Monteiro, Fernando T Ogata, Arnold Stern
Accumulating mutations may drive cells into the acquisition of abnormal phenotypes that are characteristic of cancer cells. Cancer cells feature profound alterations in proliferation programs that result in a new population of cells that overrides normal tissue construction and maintenance programs. To achieve this goal, cancer cells are endowed with up regulated survival signaling pathways. They also must counteract the cytotoxic effects of high levels of nitric oxide (NO) and of reactive oxygen species (ROS), which are by products of cancer cell growth...
August 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28918712/anger-promotes-economic-conservatism
#20
Keri L Kettle, Anthony Salerno
Research suggests that certain facets of people's political ideals can be motivated by different goals. Although it is widely accepted that emotions motivate goal-directed behavior, less is known about how emotion-specific goals may influence different facets of ideology. In this research, we examine how anger affects political ideology and through what mechanisms such effects occur. Drawing on the dual-process motivational model of ideology and the functionalist perspective of emotion, we propose that anger leads people to support conservative economic ideals, which promote economic independence and discourage societal resource sharing...
October 2017: Personality & Social Psychology Bulletin
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