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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/28433788/regulation-of-human-nucleus-pulposus-cells-by-peptide-coupled-substrates
#2
Devin T Bridgen, Bailey V Fearing, Liufang Jing, Johannah Sanchez-Adams, Megan C Cohan, Farshid Guilak, Jun Chen, Lori A Setton
Nucleus pulposus (NP) cells are derived from the notochord and differ from neighboring cells of the intervertebral disc in phenotypic marker expression and morphology. Adult human NP cells lose this phenotype and morphology with age in a pattern that contributes to progressive disc degeneration and pathology. Select laminin-mimetic peptide ligands and substrate stiffnesses were examined for their ability to regulate human NP cell phenotype and biosynthesis through the expression of NP-specific markers aggrecan, N-cadherin, collagen types I and II, and GLUT1...
April 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28433608/toward-biotechnology-in-space-high-throughput-instruments-for-in-situ-biological-research-beyond-earth
#3
REVIEW
Fathi Karouia, Kianoosh Peyvan, Andrew Pohorille
Space biotechnology is a nascent field aimed at applying tools of modern biology to advance our goals in space exploration. These advances rely on our ability to exploit in situ high throughput techniques for amplification and sequencing DNA, and measuring levels of RNA transcripts, proteins and metabolites in a cell. These techniques, collectively known as "omics" techniques have already revolutionized terrestrial biology. A number of on-going efforts are aimed at developing instruments to carry out "omics" research in space, in particular on board the International Space Station and small satellites...
April 19, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28432854/quality-of-death-rumination-and-posttraumatic-growth-among-bereaved-family-members-of-cancer-patients-in-home-palliative-care
#4
Kayo Hirooka, Hiroki Fukahori, Kanako Taku, Taisuke Togari, Asao Ogawa
OBJECTIVE: The current study was designed to test the hypothesis that quality of death (QOD) and intrusive and deliberate rumination are associated with posttraumatic growth (PTG) among bereaved family members of cancer patients in home palliative care. METHODS: Data were collected from 805 bereaved family members of cancer patients who died at home in Japan. We used a cross-sectional design and participants completed Good Death Inventory, Event-Related Rumination Inventory and PTG Inventory...
April 22, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28432853/an-evidence-based-approach-to-reducing-cardiac-telemetry-alarm-fatigue
#5
Ekta Srinivasa, Jaspreet Mankoo, Charles Kerr
BACKGROUND: It is estimated that between 80% and 99% of alarms in the clinical areas are in actionable alarms (Gross, Dahl, & Nielson). Alarm management is one of the Joint Commission's National Patient Safety Goals (2014) because sentinel events have directly been linked to the devices generating these alarms. PURPOSE: At an acute care facility in Boston, a multidisciplinary team consisting of Nursing, Biomedical Engineers, Patient Safety and Providers was formed to conduct a pilot study on the state of telemetry alarms on a surgical floor...
April 22, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28432560/executive-function-and-life-space-mobility-in-old-age
#6
Taina Poranen-Clark, Mikaela B von Bonsdorff, Merja Rantakokko, Erja Portegijs, Johanna Eronen, Markku Kauppinen, Johan G Eriksson, Taina Rantanen, Anne Viljanen
BACKGROUND: Life-space assessment incorporates all movements in terms of the distance from home, the frequency of movement and the need of assistance for movement. Executive function (EF) is an important higher order cognitive ability that controls and guides people's goal-directed actions. We examined the cross-sectional and longitudinal associations between EF and life-space mobility, and investigated if perceived walking difficulties, lower extremity performance, and transportation difficulties explain the association...
April 21, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28432341/detection-of-red-blood-cell-surface-antigens-by-probe-triggered-cell-collision-and-flow-retardation-in-an-autonomous-microfluidic-system
#7
Éva Sautner, Krisztián Papp, Eszter Holczer, Eszter L Tóth, Rita Ungai-Salánki, Bálint Szabó, Péter Fürjes, József Prechl
Microfluidic devices exploit combined physical, chemical and biological phenomena that could be unique in the sub-millimeter dimensions. The current goal of development of Point-of-Care (POC) medical devices is to extract the biomedical information from the blood. We examined the characteristics of blood flow in autonomous microfluidic devices with the aim to realize sensitive detection of interactions between particulate elements of the blood and the appropriately modified surfaces of the system. As a model experiment we demonstrated the fast analysis of the AB0 blood group system...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431364/the-humanistic-and-economic-burden-of-dravet-syndrome-on-caregivers-and-families-implications-for-future-research
#8
REVIEW
Mark P Jensen, Andreas Brunklaus, Liam Dorris, Sameer M Zuberi, Kelly G Knupp, Bradley S Galer, Arnold R Gammaitoni
We reviewed the current literature with respect to the humanistic and financial burdens of Dravet Syndrome (DS) on the caregivers of children with DS, in order to (1) identify key unanswered questions or gaps in knowledge that need to be addressed and then, based on these knowledge gaps, (2) propose a research agenda for the scientific community to address in the coming decade. The findings support the conclusion that caring for a child with DS is associated with significant humanistic burden and direct costs...
April 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28430839/pathological-imitative-behavior-and-response-preparation-in-schizophrenia
#9
Denisas Dankinas, Sigita Melynyte, Aldona Siurkute, Kastytis Dapsys
Introduction: Pathological imitative behavior (ehopraxia) is occasionally observed in schizophrenia patients. However, only a severe form of echopraxia can be detected with the help of a direct observation. Therefore, our goal was to study a latent form of pathological imitative behavior in this disorder, which is indicated by an increase of imitative tendencies. Method: In our study, 14 schizophrenia patients and 15 healthy subjects were employed in two tasks: (a) in an imitative task they had to copy a hand action seen on a screen; (b) in a counter-imitative task they had to make a different movement (which involves an inhibition of prepotent imitative tendency that is impaired in case of pathological imitative behavior)...
April 20, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28430039/distractor-resistant-stm-is-supported-by-transient-changes-in-neural-stimulus-representations
#10
Jan Derrfuss, Matthias Ekman, Michael Hanke, Marc Tittgemeyer, Christian J Fiebach
Goal-directed behavior in a complex world requires the maintenance of goal-relevant information despite multiple sources of distraction. However, the brain mechanisms underlying distractor-resistant working or STM are not fully understood. Although early single-unit recordings in monkeys and fMRI studies in humans pointed to an involvement of lateral prefrontal cortices, more recent studies highlighted the importance of posterior cortices for the active maintenance of visual information also in the presence of distraction...
April 21, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28429891/comparison-of-immunization-rates-of-adults-ages-65-years-and-older-managed-within-two-nurse-practitioner-owned-clinics-with-national-immunization-rates
#11
Wendy L Wright, Elise Morrell, Jennie Lee, Norma Graciela Cuellar, Patricia White
BACKGROUND AND PURPOSE: Adults ages ≥65 years are at increased risk for infectious diseases. Ensuring these individuals are fully vaccinated is imperative. The purpose of this study was to assess the immunization rates of adults ages ≥65 years managed by nurse practitioners (NPs) and compare the results with national immunization rates and Healthy People 2020 goals. METHODS: A convenience sample of adults ages ≥65 years was obtained from two NP-managed clinics...
April 21, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28429586/bubble-mediated-ultrasensitive-multiplex-detection-of-metal-ions-in-three-dimensional-dna-nanostructure-encoded-microchannels
#12
Xiangmeng Qu, Fan Yang, Hong Chen, Jiang Li, Hongbo Zhang, Guo-Jun Zhang, Li Li, Lihua Wang, Shiping Song, Yang Tian, Hao Pei
The development of rapid and sensitive point-of-test devices for the on-site monitoring of heavy-metal contamination has great scientific and technological importance. However, developing fast, inexpensive, and sensitive microarray sensors to achieve such goal remains challenging. In this work, we present a DNA nanostructured microarray (DNM) with tubular three-dimensional (3D) sensing surface and ordered nanotopography. This microarray enables enhanced molecular interaction toward the rapid and sensitive multiplex detection of heavy-metal ions...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28429371/design-of-a-short-non-uniform-acquisition-protocol-for-quantitative-analysis-in-dynamic-cardiac-spect-imaging-a-retrospective-123-i-mibg-animal-study
#13
Yunlong Zan, Yong Long, Kewei Chen, Biao Li, Qiu Huang, Grant T Gullberg
PURPOSE: Our previous works have found that quantitative analysis of (123) I-MIBG kinetics in the heart with dynamic single-photon emission computed tomography (SPECT) offers the potential to quantify the innervation integrity at an early stage of left ventricular hypertrophy. However, conventional protocols involving a long acquisition time for dynamic imaging reduce the animal survival rate and thus make longitudinal analysis difficult. The goal of this work was to develop a procedure to reduce the total acquisition time by selecting non-uniform acquisition times for projection views while maintaining the accuracy and precision of estimated physiologic parameters...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28429060/engineered-jadomycin-analogues-with-altered-sugar-moieties-revealing-jads-as-a-substrate-flexible-o-glycosyltransferase
#14
Liyuan Li, Guohui Pan, Xifen Zhu, Keqiang Fan, Wubin Gao, Guomin Ai, Jinwei Ren, Mingxin Shi, Carlos Olano, José A Salas, Keqian Yang
Glycosyltransferases (GTs)-mediated glycodiversification studies have drawn significant attention recently, with the goal of generating bioactive compounds with improved pharmacological properties by diversifying the appended sugars. The key to achieving glycodiversification is to identify natural and/or engineered flexible GTs capable of acting upon a broad range of substrates. Here, we report the use of a combinatorial biosynthetic approach to probe the substrate flexibility of JadS, the GT in jadomycin biosynthesis, towards different non-native NDP-sugar substrates, enabling us to identify six jadomycin B analogues with different sugar moieties...
April 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28428283/regulatory-aspects-of-optical-methods-and-exogenous-targets-for-cancer-detection
#15
Willemieke S Tummers, Jason M Warram, Kiranya E Tipirneni, John Fengler, Paula Jacobs, Lalitha Shankar, Lori Henderson, Betsy Ballard, Brian W Pogue, Jamey P Weichert, Michael Bouvet, Jonathan Sorger, Christopher H Contag, John V Frangioni, Michael F Tweedle, James P Basilion, Sanjiv S Gambhir, Eben L Rosenthal
Considerable advances in cancer-specific optical imaging have improved the precision of tumor resection. In comparison to traditional imaging modalities, this technology is unique in its ability to provide real-time feedback to the operating surgeon. Given the significant clinical implications of optical imaging, there is an urgent need to standardize surgical navigation tools and contrast agents to facilitate swift regulatory approval. Because fluorescence-enhanced surgery requires a combination of both device and drug, each may be developed in conjunction, or separately, which are important considerations in the approval process...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28428175/flavored-e-cigarette-liquids-reduce-proliferation-and-viability-in-the-calu3-airway-epithelial-cell-line
#16
Temperance R Rowell, Steven L Reeber, Shernita L Lee, Rachel A Harris, Rachel C Nethery, Amy H Herring, Gary L Glish, Robert Tarran
E-cigarettes are generally thought of as a safer smoking alternative to traditional cigarettes. However, little is known about the effects of e-cigarette liquids (e-liquids) on the lung. Since over 7,000 unique flavors have been identified for purchase in the USA, our goal was to conduct a screen that would test whether different flavored e-liquids exhibited different toxicant profiles. We tested the effects of 13 different flavored e-liquids (with nicotine and propylene glycol/vegetable glycerin (PG/VG) serving as controls) on a lung epithelial cell line (CALU3)...
April 20, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28427051/subjective-time-perceptions-and-aging-well-a-review-of-concepts-and-empirical-research-a-mini-review
#17
Martina Gabrian, Anne J Dutt, Hans-Werner Wahl
Human beings impose subjective, time-related interpretations on their existence, and the experience of time is a major aspect of lifespan development. In this mini-review, we understand subjective time as the way individuals subjectively perceive and evaluate the passing of their personal "objective" lifetime. A broad range of constructs and operationalizations has been developed in (gero-) psychology to capture subjective time, including future time perspective, personal goals, or autobiographical memories...
April 21, 2017: Gerontology
https://www.readbyqxmd.com/read/28426512/technology-in-s-c-assessing-bodyweight-squat-technique-with-wearable-sensors
#18
Martin A O'Reilly, Darragh F Whelan, Tomas E Ward, Eamonn Delahunt, Brian M Caulfield
Strength and conditioning (S&C) coaches offer expert guidance to help those they work with achieve their personal fitness goals. However it is not always practical to operate under the direct supervision of an S&C coach and consequently individuals are often left training without expert oversight. Recent developments in inertial measurement units (IMUs) and mobile computing platforms have allowed for the possibility of unobtrusive motion tracking systems and the provision of real-time individualised feedback regarding exercise performance...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28426437/supersonic-transient-magnetic-resonance-elastography-for-quantitative-assessment-of-tissue-elasticity
#19
Yu Liu, Jingfei Liu, Brett Z Fite, Josquin Foiret, Asaf Ilovitsh, J Kent Leach, Erik Dumont, Charles F Caskey, Katherine W Ferrara
Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal...
April 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28426264/differences-between-treatment-seeking-and-non-treatment-seeking-participants-in-medication-studies-for-alcoholism-do-they-matter
#20
Lara A Ray, Spencer Bujarski, Megan M Yardley, Daniel J O Roche, Emily E Hartwell
BACKGROUND: Medication development for alcoholism typically includes experimental pharmacology studies with non-treatment-seeking individuals with alcohol use disorder (AUD) paving the way for randomized controlled trials in treatment-seekers with AUD. OBJECTIVES: The goal of this study is to provide a direct comparison between AUD treatment-seeking research participants and non-treatment-seeking participants on demographic and clinical variables and to test whether variables that differentiate the two groups are associated with clinical outcomes...
April 20, 2017: American Journal of Drug and Alcohol Abuse
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