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https://www.readbyqxmd.com/read/27907872/does-unilateral-single-event-multilevel-surgery-improve-gait-in-children-with-spastic-hemiplegia-a-retrospective-analysis-of-a-long-term-follow-up
#1
Christian Schranz, Annika Kruse, Tanja Kraus, Gerhardt Steinwender, Martin Svehlik
Single event multilevel surgery (SEMLS) has become a standard intervention for children with cerebral palsy (CP). SEMLS proved to improve the gait in bilateral spastic cerebral palsy and those improvements can be maintained in the long term. However there is no evidence on the long-term outcome of unilateral SEMLS in children with unilateral spastic cerebral palsy. The gait analyses and clinical data of 14 children (9 male/5 female, mean age 12.1) with unilateral CP (6 children Gross Motor Function Classification System Scale level I and 8 children level II) were retrospectively reviewed at four time-points: preoperatively, 1year, 3-5 years and approximately 10 years after unilateral SEMLS...
November 15, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27903315/gait-and-posture-discrimination-in-sheep-using-a-tri-axial-accelerometer
#2
M Radeski, V Ilieski
Temporo-spatial observation of the leg could provide important information about the general condition of an animal, especially for those such as sheep and other free-ranging farm animals that can be difficult to access. Tri-axial accelerometers are capable of collecting vast amounts of data for locomotion and posture observations; however, interpretation and optimization of these data records remain a challenge. The aim of the present study was to introduce an optimized method for gait (walking, trotting and galloping) and posture (standing and lying) discrimination, using the acceleration values recorded by a tri-axial accelerometer mounted on the hind leg of sheep...
December 1, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27899680/normative-tandem-gait-in-collegiate-student-athletes-implications-for-clinical-concussion-assessment
#3
Jessie R Oldham, Melissa S DiFabio, Thomas W Kaminski, Ryan M DeWolf, Thomas A Buckley
BACKGROUND: Impaired balance is common after concussion. The third edition of the Sport Concussion Assessment Tool (SCAT-3) recommends the Balance Error Scoring System (BESS) and/or tandem gait for postconcussion balance assessment. The limitations of the BESS are well documented; however, tandem gait has received little attention throughout concussion literature. The purpose of this study was to provide normative data for tandem gait in collegiate student-athletes based on sport type, concussion history, and gender...
November 29, 2016: Sports Health
https://www.readbyqxmd.com/read/27876030/long-term-outcomes-following-lower-extremity-press-fit-bone-anchored-prosthesis-surgery-a-5-year-longitudinal-study-protocol
#4
Ruud A Leijendekkers, J Bart Staal, Gerben van Hinte, Jan Paul Frölke, Hendrik van de Meent, Femke Atsma, Maria W G Nijhuis-van der Sanden, Thomas J Hoogeboom
BACKGROUND: Patients with lower extremity amputation frequently suffer from socket-related problems. This seriously limits prosthesis use, level of activity and health-related quality of life (HRQoL). An additional problem in patients with lower extremity amputation are asymmetries in gait kinematics possibly accounting for back pain. Bone-anchored prostheses (BAPs) are a possible solution for socket-related problems. Knowledge concerning the level of function, activity and HRQoL after surgery is limited...
November 22, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27869535/serum-thyroid-stimulating-hormone-levelsand-frailty-in-the-elderly-the-pro-v-a-study
#5
Nicola Veronese, Sara Watutantrige, Stefania Maggi, Marianna Noale, Brendon Stubbs, Raffaele Antonelli Incalzi, Sabina Zambon, Maria Chiara Corti, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
High or low thyroid-stimulating hormone (TSH) levels seem to be associated with several negative outcomes in the elderly, but the literature about TSH and frailty is still limited. In this paper, we investigated whether TSH is associated with prevalent and incident frailty in a cohort of older community-dwelling subjects. Among 3,099 initially screened in the Progetto Veneto Anziani Study, 2,571 men and women aged >65 years (for cross-sectional analyses) and 1,732 (longitudinal, mean follow-up period of 4...
November 21, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27869301/cerebral-amyloid-deposition-is-associated-with-gait-parameters-in-the-mayo-clinic-study-of-aging
#6
Alexandra M V Wennberg, Rodolfo Savica, Clinton E Hagen, Rosebud O Roberts, David S Knopman, John H Hollman, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, Michelle M Mielke
OBJECTIVES: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. DESIGN: Cross-sectional. SETTING: Population-based cohort study in Olmsted County, MN. PARTICIPANTS: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27867020/a-randomized-dose-escalation-study-of-intravenous-baclofen-in-healthy-volunteers-clinical-tolerance-and-pharmacokinetics
#7
Natalie S Schmitz, Linda E Krach, Lisa D Coles, Usha Mishra, Suresh K Agarwal, James C Cloyd, Robert L Kriel
BACKGROUND: Abrupt discontinuation of baclofen can result in a potentially severe withdrawal syndrome. The current treatment for baclofen withdrawal is inadequate, resulting in a critical need to develop an alternative method to prevent or treat this withdrawal syndrome. OBJECTIVE: To evaluate the safety profile and pharmacokinetics of oral (PO) and investigational intravenous (IV) baclofen formulations at clinically relevant doses. DESIGN: Randomized, open-label, dose escalation, crossover study SETTING: Contract Research Organization (CRO) METHODS: Three cohorts of 12 healthy adults received single doses of PO baclofen (10mg, 15 mg or 20 mg) and 10-minute infusions of IV baclofen (7...
November 17, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27860360/homozygous-variants-in-pyrroline-5-carboxylate-reductase-2-pycr2-in-patients-with-progressive-microcephaly-and-hypomyelinating-leukodystrophy
#8
Linyan Meng, Taraka Donti, Fan Xia, Zhiyv Niu, Aisha Al Shamsi, Jozef Hertecant, Fatma Al-Jasmi, James B Gibson, Honey Nagakura, Jing Zhang, Weimin He, Christine Eng, Yaping Yang, Sarah H Elsea
Pyrroline-5-carboxylate reductase 2, encoded by PYCR2, is one of the three homologous enzymes that catalyze the last step of proline synthesis. Homozygous variants in PYCR2 have been reported in patients from multiple consanguineous families with hypomyelinating leukodystrophy 10 (HLD10) (MIM: 616420). Here, we report five additional patients from three families with homozygous nonsense or missense variants in PYCR2, identified through clinical exome sequencing. All patients presented with postnatally acquired microcephaly, moderate to profound global developmental delay, and failure to thrive...
November 11, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27848928/maximum-relative-speeds-of-living-organisms-why-do-bacteria-perform-as-fast-as-ostriches
#9
Nicole Meyer-Vernet, Jean-Pierre Rospars
Self-locomotion is central to animal behaviour and survival. It is generally analysed by focusing on preferred speeds and gaits under particular biological and physical constraints. In the present paper we focus instead on the maximum speed and we study its order-of-magnitude scaling with body size, from bacteria to the largest terrestrial and aquatic organisms. Using data for about 460 species of various taxonomic groups, we find a maximum relative speed of the order of magnitude of ten body lengths per second over a 10(20)-fold mass range of running and swimming animals...
November 15, 2016: Physical Biology
https://www.readbyqxmd.com/read/27843743/comparison-of-a-robotic-assisted-gait-training-program-with-a-program-of-functional-gait-training-for-children-with-cerebral-palsy-design-and-methods-of-a-two-group-randomized-controlled-cross-over-trial
#10
Alicia J Hilderley, Darcy Fehlings, Gloria W Lee, F Virginia Wright
BACKGROUND: Enhancement of functional ambulation is a key goal of rehabilitation for children with cerebral palsy (CP) who experience gross motor impairment. Physiotherapy (PT) approaches often involve overground and treadmill-based gait training to promote motor learning, typically as free walking or with body-weight support. Robotic-assisted gait training (RAGT), using a device such as the Lokomat(®)Pro, may permit longer training duration, faster and more variable gait speeds, and support walking pattern guidance more than overground/treadmill training to further capitalize on motor learning principles...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27836806/hypometric-anticipatory-postural-adjustments-in-dystonia-are-not-affected-by-deep-brain-stimulation-of-globus-pallidus-internus
#11
Gregor Brecl Jakob, Olena Pelykh, Annika Plate, Zuzana Košutzká, Zvezdan Pirtošek, Maja Trošt, Joseph Ilmberger, Peter Valkovic, Jan H Mehrkens, Kai Bötzel
BACKGROUND: Dystonia is a movement disorder with patterned, directional, and often sustained muscle contractions that produce abnormal postures or repetitive movements. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective and safe treatment for medically refractory dystonia. However, recent studies reported gait problems, gait freezing and falls in patients treated with DBS. Because these symptoms may point to deficient gait initiation processes, we systematically assessed the anticipatory postural adjustments (APAs) prior to stepping in dystonia patients with GPi-DBS...
November 9, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27836308/targeting-the-underlying-causes-of-undernutrition-cost-effectiveness-of-a-multifactorial-personalized-intervention-in-community-dwelling-older-adults-a-randomized-controlled-trial
#12
Rachel van der Pols-Vijlbrief, Hanneke A H Wijnhoven, Judith E Bosmans, Jos W R Twisk, Marjolein Visser
BACKGROUND & AIMS: Undernutrition in old age is associated with increased morbidity, mortality and health care costs. Treatment by caloric supplementation results in weight gain, but compliance is poor in the long run. Few studies targeted underlying causes of undernutrition in community-dwelling older adults. This study aimed to evaluate the cost-effectiveness of a multifactorial personalized intervention focused on eliminating or managing the underlying causes of undernutrition to prevent and reduce undernutrition in comparison with usual care...
October 15, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27819400/-instrumental-gait-analysis-in-stroke-patients
#13
P Fernandez-Gonzalez, F Molina-Rueda, A Cuesta-Gomez, M Carratala-Tejada, J C Miangolarra-Page
INTRODUCTION: The motor control deficits after stroke affect the gait pattern. There is a significant variability between subjects. AIMS: To analyse, by using a capture motion system, the gait pattern in stroke patients with different levels of motor function, and to establish, despite the participants heterogeneity, what alterations in the gait pattern are usual in each participant. SUBJECTS AND METHODS: Nine stroke subjects with independent gait and ten control subjects participated in this study...
November 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27819211/perches-and-elevated-platforms-in-commercial-broiler-farms-use-and-effect-on-walking-ability-incidence-of-tibial-dyschondroplasia-and-bone-mineral-content
#14
E Kaukonen, M Norring, A Valros
Modern fast-growing broilers spend excessive periods resting and their activity further decreases with age. Inactivity has been suggested to increase impaired gait and the incidence of leg disorders. Tibial dyschondroplasia (TD) is a common leg pathology in broilers. A more complex environment might facilitate more activity and improve leg health. Perches or elevated platforms bring variety to broilers' environment and could motivate more locomotion. This study examined the impact of perches and elevated platforms on walking ability, the occurrence of TD and level of bone ash and mineral contents...
November 7, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27816027/cognitive-impairment-in-patients-with-parkinson-s-disease-a-30-month-follow-up-study
#15
Ling Chen, Cuiyu Yu, Ning Zhang, Junjun Liu, Weiguo Liu
OBJECTIVE: A longitudinal (30-month) study of the cognitive changes in Parkinson's disease patients and analysis of influencing factors. METHODS: The cognitive function and related symptoms of 102 patients with idiopathic Parkinson's disease were assessed using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and relevant scales, at baseline and 30-month follow-up. The t-test, nonparametric tests, and regression analyses were used to evaluate cognitive decline and investigate risk factors for cognitive impairment...
October 4, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27815704/relationships-between-lower-body-strength-and-the-energy-cost-of-treadmill-walking-in-a-cohort-of-healthy-older-adults-a-cross-sectional-analysis
#16
Nicolas Berryman, Louis Bherer, Sylvie Nadeau, Séléna Lauzière, Lora Lehr, Florian Bobeuf, Marie Jeanne Kergoat, Thien Tuong Minh Vu, Laurent Bosquet
PURPOSE: Gait speed is associated with survival in older adults and it was suggested that an elevated energy cost of walking (Cw) is an important determinant of gait speed reduction. Thus far, little is known about the factors that contribute to a lower Cw but it was shown that lower body strength training could reduce the Cw. Therefore, the objective of this study was to investigate the relationship between lower body strength and the Cw in a cohort of healthy older adults. METHODS: A total of 48 participants were included in this study (70...
November 4, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27811156/the-importance-of-mid-to-late-life-body-mass-index-trajectories-on-late-life-gait-speed
#17
B Gwen Windham, Michael E Griswold, Wanmei Wang, Anna Kucharska-Newton, Ellen W Demerath, Kelley Pettee Gabriel, Lisa A Pompeii, Kenneth Butler, Lynne Wagenknecht, Stephen Kritchevsky, Thomas H Mosley
BACKGROUND: Prior studies suggest being overweight may be protective against poor functional outcomes in older adults. METHODS: Body mass index (BMI, kg/m(2)) was measured over 25 years across five visits (1987-2011) among Atherosclerosis Risk in Communities Study participants (baseline Visit 1 n = 15,720, aged 45-64 years). Gait speed was measured at Visit 5 ("late-life", aged ≥65 years, n = 6,229). BMI trajectories were examined using clinical cutpoints and continuous mixed models to estimate effects of patterns of BMI change on gait speed, adjusting for demographics and comorbidities...
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27810267/walking-aids-moderate-exercise-effects-on-gait-speed-in-people-with-dementia-a-randomized-controlled-trial
#18
Annika Toots, Håkan Littbrand, Henrik Holmberg, Peter Nordström, Lillemor Lundin-Olsson, Yngve Gustafson, Erik Rosendahl
OBJECTIVES: To investigate the effects of exercise on gait speed, when tested using walking aids and without, and whether effects differed according to amount of support in the test. DESIGN: A cluster-randomized controlled trial. SETTING: The Umeå Dementia and Exercise (UMDEX) study was set in 16 nursing homes in Umeå, Sweden. PARTICIPANTS: One hundred forty-one women and 45 men (mean age 85 years) with dementia, of whom 145 (78%) habitually used walking aids...
October 31, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27809913/long-term-safety-and-efficacy-of-omnitrope%C3%A2-a-somatropin-biosimilar-in-children-requiring-growth-hormone-treatment-italian-interim-analysis-of-the-patro-children-study
#19
Lorenzo Iughetti, Gianluca Tornese, Maria Elisabeth Street, Flavia Napoli, Claudia Giavoli, Franco Antoniazzi, Stefano Stagi, Caterina Luongo, Sara Azzolini, Letizia Ragusa, Gianni Bona, Clara Zecchino, Tommaso Aversa, Luca Persani, Laura Guazzarotti, Emiliano Zecchi, Alberto Pietropoli, Stefano Zucchini
BACKGROUND: PATRO Children is an ongoing observational, longitudinal, non-interventional, global post-marketing surveillance study, which is investigating the long-term safety and effectiveness of Omnitrope®, a somatropin biosimilar to Genotropin®, in children with growth disturbances. The primary endpoint of PATRO Children is long-term safety and the secondary endpoint is effectiveness, which is assessed by analysing auxological data such as height (HSDS) and height velocity (HVSDS) standard deviation scores...
November 3, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27800020/two-year-real-world-experience-with-perampanel-in-patients-with-refractory-focal-epilepsy-austrian-data
#20
Alexandra Rohracher, Gudrun Kalss, Markus Leitinger, Claudia Granbichler, Ildiko Deak, Judith Dobesberger, Giorgi Kuchukhidze, Aljoscha Thomschewski, Julia Höfler, Eugen Trinka
BACKGROUND: The aim of this study was to analyse registry data of seizure outcome and adverse events (AEs) for perampanel as add-on therapy in patients with focal epilepsy since its approval in 2012 for adjunctive treatment of focal epilepsy in patients ⩾12 years. METHOD: A retrospective 2-year chart review of all patients receiving perampanel was carried out. RESULTS: A total of 122 patients received perampanel [median treatment length: 20...
November 2016: Therapeutic Advances in Neurological Disorders
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