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https://www.readbyqxmd.com/read/29783282/sustained-conduction-of-vasomotor-responses-in-rat-mesenteric-arteries-in-a-two-compartment-in-vitro-setup
#1
Teresa Palao, Angela van Weert, Anne de Leeuw, Judith de Vos, Erik N T P Bakker, Ed van Bavel
AIM: Conduction of vasomotor responses may contribute to long-term regulation of resistance artery function and structure. Most previous studies have addressed conduction of vasoactivity only during very brief stimulations. We developed a novel setup that allows the local pharmacological stimulation of arteries in vitro for extended periods of time, and studied the conduction of vasomotor responses in rat mesenteric arteries under those conditions. METHODS: The new in vitro set up was based on the pressure myograph...
May 21, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29783271/mid-term-clinical-outcome-and-reconstruction-of-posterior-tibial-slope-after-uka
#2
Alois Franz, Christoph Kolja Boese, Andrej Matthies, Jörg Leffler, Christian Ries
Unicompartmental knee arthroplasty (UKA) has gained growing popularity over the last decades. The posterior tibial slope (PTS) has been shown to play a significant role for knee biomechanics and is thought to be crucial for clinical function of the UKA. We evaluated the clinical outcome at mid-term follow-up after UKA. Furthermore, the reconstruction of the individual PTS was analyzed. A total of 91 consecutive patients undergoing medial UKA for osteoarthritis were included. Patients were contacted by telephone for a survival analysis at a minimum of 30 months after surgery...
May 21, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29783266/multiorgan-failure-syndrome-in-newborns-role-of-social-and-anatomico-functional-features-literature-review
#3
Dmytro A Skurupii, Evgeniy G Sonnyk, Vitaliy M Sizonenko
Protection of maternal health as well as protection of fetal and newborn health is a strategic objective in all countries. It ensures the formation of healthy generation as the basis of gene pool preservation and further development of the nation. It is known that the progress of critical conditions in newborns is different from classical concepts. Аnatomicofunctional features of the newborns (especially premature newborns), the effect of prenatal pathological factors are provocative and background factors of the multiorgan failure syndrome begining in these patients, which probably affects frequency of appearance of this syndrome, the mechanisms of development, clinical manifestations, the final of the disease and makes doctors to consider newborns in critical conditions as high-risk group for multiorgan failure syndrome appearance...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783264/the-use-of-immunohistochemical-methods-in-the-study-of-morphofunctional-features-of-the-human-paranasal-sinuses-literature-review
#4
Mykhailo M Koptev, Nataliia I Vynnyk, Oksana V Kokovska, Olena М Pronina, Serhii М Bilash
OBJECTIVE: Introduction:Chronic inflammatory diseases of the mucous membrane of the nose, paranasal sinuses, and pharynx are the most widespread pathology of the upper airways. The thorough study of the features of the organization of local immune protection of the mucous membrane of the paranasal sinuses is crucial for the deep understanding of the causes of the onset and development of this and other pathologies of the paranasal sinuses, the choice of methods of diagnostics and treatment...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783258/-theoretical-grounds-of-a-structural-and-functional-model-for-quality-assurance-of-radiation-diagnostics-under-conditions-of-development-of-the-modern-health-care-system-in-ukraine
#5
Oleg A Korop, Sergiy V Lenskykh
OBJECTIVE: Introduction: Modern changes in the health care system of Ukraine are focused on financial support in providing medical and diagnostic care to the population and are based on deep and consistent structural and functional transformations. They are aimed at providing adequate quality care, which is the main target function and a principal criterion for operation of health care system. The urgency of this problem is increasing in the context of reforming the health care system and global changes in the governmental financial guarantees for the provision of medical services to the population...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783253/planning-of-effective-evaluation-of-the-activities-of-hospital-district-at-the-example-of-poltava-region
#6
Vyacheslav M Zhdan, Valentyn M Dvornyk, Viktor P Lysak, Igor M Skrypnyk, Valeriy I Pokhylko, Iryna A Holovanova, Inna V Bielikova, Maxim V Khorosh, Ludmila M Shylkina, Mariya M Tovstiak
OBJECTIVE: Introduction: Increasing of the availability and quality of health care in rural areas is one of the priority directions of public health and regional development policy. The need for reforming of the network of secondary health care facilities is due to the fact, that they are unable to meet the needs of the population in this specialized type of medical care in the conditions of the existing structure and funding system. The aim: to analyze the existing legislation regulating the establishment and operation of hospital districts; to determine the methodology for monitoring and evaluating of the activity of the hospital district on the example of the Poltava region...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783243/-electromyographic-characteristics-of-temporal-and-masticatory-muscles-in-patients-with-compression-dislocation-dysfunction-of-temporomandibular-joints-of-different-severity
#7
Pavlo I Yatsenko, Oleg V Rybalov, Oleg I Yatsenko, Vadym M Novikov, Dmytro M Kоrol, Dmytro D Kindiy, Victor D Kindiy
OBJECTIVE: Introduction: The main causes of dysfunctional conditions of the temporomandibular joints (TMJ), are occlusal, neurogenic, orthodontic disorders. The muscular component of TMJ is determines the dynamic anatomical and functional state of the mandible Therefore, in the diagnosis of dysfunctions and understanding of their pathogenesis belongs to the electromyographic method of investigation. The aim of the work was a comparative assessment of the bioelectrical activity of the actual chewing and temporal muscles in patients with musculo-articular compressiondislocation dysfunction of the TMJ of various severity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783240/-effect-of-preventive-treatment-on-cognitive-performance-in-patients-with-multiple-sclerosis
#8
Maria S Shorobura
OBJECTIVE: Introduction: cognitive, emotional and psychopathological changes play a significant role in the clinical picture of multiple sclerosis and influence the effectiveness of drug therapy, working capacity, quality of life, and the process of rehabilitation of patients with multiple sclerosis. The aim: investigate the changes in cognitive function in patients with multiple sclerosis, such as information processing speed and working memory of patients before and after treatment with immunomodulating drug...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783234/-myocardial-bridge-as-the-only-cause-of-acute-coronary-syndrome-among-the-young-patients
#9
Liudmila O Miakinkova, Yurii V Teslenko, Irina V Tsyhanenko
OBJECTIVE: Introduction: Myocardial bridge is an inborn anomaly of coronary artery development, when a part of it is submerged in a myocard, which is pressing the coronary artery to a systola and restrains coronary blood circulation. Generally this feature of coronary blood circulation does not cause any clinical symptoms because the 85% of coronary blood stream of the left ventricle is provided by diastolic filling. Hemodynamic changes in atherosclerosis, tahicardie, hypertrophie of myocard are leading to the manifestation of clinical symptoms of ischemia...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783231/allergenic-weed-pollen-forecast-under-the-mathematical-modeling-method-implementation-in-ukraine
#10
Irina I Motruk, Michael Yu Antomonov, Victoria V Rodinkova, Olena E Aleksandrova, Oleh V Yermishev
OBJECTIVE: Introduction: Allergies are the most common reason of the chronic diseases in developed countries and represent an important medical, social and economic issue, the relevance of which is growing both in these countries and in Ukraine. The most famous of these allergens group is the pollen of ambrosia and pollen of poaceae, which are ubiquitously distributed in the subtropical and temperate climate. The aim: The objective of our study was to develop the mathematical models, which will be able to indicate the probability of the pollen circulation, and thus these models can simplify the forecast of symptoms risk and improve the prophylaxis of pollinosis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783229/-morphological-characteristics-of-kidneys-connective-tissue-of-mature-fetuses-and-newborns-from-mothers-whose-pregnancy-was-complicated-by-preeclampsia-of-varying-degrees-of-severity
#11
Iryna V Sorokina, Mykhailo S Myroshnychenko, Nataliia V Kapustnyk, Tetyana O Khramova, Oksana V Dehtiarova, Svitlana I Danylchenko
OBJECTIVE: Introduction: The kidneys connective tissue condition in the antenatal period affects the formation of tissues and it changes with the development of various general pathological processes in this organ. The aim of the study was to identify the morphological features of kidneys connective tissue of fetuses and newborns from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity. PATIENTS AND METHODS: Materials and methods: The material of the study was the tissue of kidneys of mature fetuses and newborns from mothers with physiological pregnancy (28 cases), as well as from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity (78 cases)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783225/-features-of-exchange-of-calcium-saliva-in-patients-with-gastroesophageal-reflux-disease
#12
Mykola А Bychkov, Maryana М Yakhnitska
OBJECTIVE: Introduction: The pathogenesis of gastroesophageal reflux disease (GERD) is a topical issue of modern gastroenterology. There are a number of scientific papers on changes in the qualitative and quantitative composition of saliva, which triggers a cascade of biochemical reactions, the consequence of which is the destruction of the resistance of the mucous membrane of the esophagus. Calcium is a macro element that provides the normal functioning of cells. Parathormone also regulates the metabolism of calcium in the body...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783221/hygienic-assessment-of-different-forms-of-physical-education-lessons-organization-in-primary-school
#13
Oleksandra S Kondratiuk, Maria M Korshun, Sergii I Garkavyi, Sergii S Garkavyi, Liudmyla A Stasiuk, Olena V Dema, Olga O Sokolovska
OBJECTIVE: Introduction: Different forms of physical education lessons organization, including swimming classes were introduced in education process without studying of its healthsaving effectiveness. The aim of this study was hygienic assessment of different forms of physical education lessons organization in primary school. PATIENTS AND METHODS: Materials and methods: Cross-sectional study was conducted in two schools with different organization of physical education lessons...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783206/-experimental-evaluation-of-the-therapeutic-potential-of-liposome-mediated-apoe3-gene-transfection-for-cerebral-atherosclerosis
#14
Vadym V Biloshytskyi, Alisa V Pachevska, Alina V Biloshytska, Valerii M Istoshyn, Maryna V Biloshytska, Olha B Shevnia
OBJECTIVE: Introduction: In recent years, a stroke has been the cause of high lethality, long-term and sustained disability, the problem of which is still far from being resolved. The root cause of stroke is atherosclerosis. The aim: Study of neurotrophic and neuroprotective functions of apoE in rat brain tissue in experimental atherosclerosis. PATIENTS AND METHODS: Materials and methods: The study included 60 sexually mature rats. The model of experimental atherosclerosis was created by Anichkov method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783203/mechanical-characterization-and-ion-release-of-bioactive-dental-composites-containing-calcium-phosphate-particles
#15
Livia C Natale, Marcela C Rodrigues, Yvette Alania, Marina D S Chiari, Leticia C C Boaro, Marycel Cotrim, Oscar Vega, Roberto R Braga
OBJECTIVE: to verify the effect of the addition of dicalcium phosphate dihydrate (DCPD) particles functionalized with di- or triethylene glycol dimethacrylate (DEGDMA or TEGDMA) on the degree of conversion (DC), post-gel shrinkage (PS), mechanical properties, and ion release of experimental composites. METHODS: Four composites were prepared containing a BisGMA/TEGDMA matrix and 60 vol% of fillers. The positive control contained only barium glass fillers, while in the other composites 15 vol% of the barium was replaced by DCPD...
May 18, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29783201/n-4-18-f-fluorobenzyl-cholylglycine-a-novel-tracer-for-pet-of-enterohepatic-circulation-of-bile-acids-radiosynthesis-and-proof-of-concept-studies-in-rats
#16
Kim Frisch, Damion H R Stimson, Taracad Venkatachalam, Gregory K Pierens, Susanne Keiding, David Reutens, Rajiv Bhalla
INTRODUCTION: Enterohepatic circulation (EHC) of conjugated bile acids is an important physiological process crucial for regulation of intracellular concentrations of bile acids and their function as detergents and signal carriers. Only few bile acid-derived imaging agents have been synthesized and hitherto none have been evaluated for studies of EHC. We hypothesized that N-(4-[18 F]fluorobenzyl)cholylglycine ([18 F]FBCGly), a novel fluorine-18 labeled derivative of endogenous cholylglycine, would be a suitable tracer for PET of the EHC of conjugated bile acids, and we report here a radiosynthesis of [18 F]FBCGly and a proof-of-concept study by PET/MR in rats...
May 4, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29783189/sall2-knockdown-exacerbates-palmitic-acid-induced-dysfunction-and-apoptosis-of-pancreatic-nit-1-beta-cells
#17
Ye Wang, Jie Liu, Zheng Liu, Jing Chen, Xuemei Hu, Yimeng Hu, Yin Yuan, Guijun Wu, Zhe Dai, Yancheng Xu
Spalt-like (Sall) proteins are a class of transcription factors. The role of Sall2 in beta cells remain poorly understood. Here, we aimed to explore whether Sall2 involved in lipotoxicity-mediated dysfunction and apoptosis in pancreatic NIT-1 beta cells. Our results showed that high concentrations of palmitic acid (PA) led to impaired cell viability and decreased Sall2 expression in NIT-1 cells. Knocking down of Sall2 in NIT-1 cells resulted in increased sensitivity to lipotoxicity and caused higher rates of cell apoptosis following PA treatment...
May 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29783186/-1-h-nmr-and-uplc-ms-metabolomics-functional-tools-for-exploring-chemotypic-variation-in-sceletium-tortuosum-from-two-provinces-in-south-africa
#18
Jianping Zhao, Ikhlas A Khan, Sandra Combrinck, Maxleene Sandasi, Weiyang Chen, Alvaro M Viljoen
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as for obsessive compulsive disorders. A comprehensive intraspecies chemotypic variation study, using samples harvested from two distinct regions of South Africa, was done using both proton nuclear magnetic resonance (1 H-NMR) spectroscopy of methanol extracts (N = 145) and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) of acid/base extracts (N = 289). Chemometric analysis of the 1 H-NMR data indicated two main clusters that were region-specific (Northern Cape and Western Cape provinces)...
May 17, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29783181/autistic-traits-in-epilepsy-models-why-when-and-how
#19
REVIEW
Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre-Pascal Lenck-Santini
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models...
May 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29783174/facile-isolation-of-%C3%AE-ribazole-from-vitamin-b-12-hydrolysates-using-boronate-affinity-chromatography
#20
Theodoric A Mattes, Jorge C Escalante-Semerena
Alpha-ribazole (α-R) is a unique riboside found in the nucleotide loop of coenzyme B12 (CoB12 ). α-R is not an intermediate of the de novo biosynthetic pathway of coenzyme B12 , but some bacteria of the phylum Firmicutes have evolved a two-protein system (transporter, kinase) that scavenges α-R from the environment and converts it to the pathway intermediate α-RP. Since α-R is not commercially available, one must either synthesize α-R, or isolate it from hydrolysates of vitamin B12 (cyano-B12 , CNB12 ), so the function of the above-mentioned proteins can be studied...
May 16, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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