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Per Jonsson

André Brännström, Ji-Guo Yu, Per Jonsson, Torbjörn Åkerfeldt, Mats Stridsberg, Michael Svensson
The present work investigated serum vitamin D (25(OH)D) status in relation to bone and muscle qualities and functions in 19 female soccer players (13-16 years) resident at northern latitude with very low sun exposure (∼32-36 h/month) during winter season (late January to early March). Serum 25(OH)D, parathyroid hormone and bone turnover markers osteocalcin (OC) and beta carboxy-terminal collagen cross-links (β-Ctx), as well as body composition and muscle performance were examined. Hormones were tested using routine laboratory methods...
September 15, 2016: European Journal of Sport Science
Bengt Jönsson, Thomas Hofmarcher, Peter Lindgren, Nils Wilking
BACKGROUND: There is an intense debate about the cost of cancer and the value of new treatments. However, there is limited data on the cost of cancer in the European Union (EU) and how costs relate to the burden of disease. This paper presents new estimates on the development of the cost of cancer in the EU 1995-2014, with a focus on the major cost components: total health expenditure, cancer drugs, and production loss due to premature mortality. METHODS: Data on overall health expenditure were combined with national disease estimates to derive cancer-specific health expenditure...
October 2016: European Journal of Cancer
Anders Wimo, Maëlenn Guerchet, Gemma-Claire Ali, Yu-Tzu Wu, A Matthew Prina, Bengt Winblad, Linus Jönsson, Zhaorui Liu, Martin Prince
INTRODUCTION: In 2010, Alzheimer's Disease International presented estimates of the global cost of illness (COI) of dementia. Since then, new studies have been conducted, and the number of people with dementia has increased. Here, we present an update of the global cost estimates. METHODS: This is a societal, prevalence-based global COI study. RESULTS: The worldwide costs of dementia were estimated at United States (US) $818 billion in 2015, an increase of 35% since 2010; 86% of the costs occur in high-income countries...
August 29, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Knud Andreas Jønsson, Kaspar Delhey, George Sangster, Per G P Ericson, Martin Irestedt
No abstract text is available yet for this article.
August 31, 2016: Proceedings. Biological Sciences
Thorhildur Halldorsdottir, Halldor Jonsson, Kristjan G Gudmundsson
Objective. Icelandic society is rapidly changing, from being an ethnically homogeneous population towards a multicultural immigrant society. In the hope of optimizing the service for immigrants at the health care centre, we decided to evaluate health care utilization by immigrants. Methods. As a case control study we invited all immigrants that attended the health care centre during a two-week period to participate. Paired controls of Icelanders were invited for comparison. Results. There were 57 immigrants, 48 females and 9 males, from 27 countries...
2016: International Journal of Family Medicine
Ulf Jonsson, Göran Bertilsson, Per Allard, Harald Gyllensvärd, Anne Söderlund, Anne Tham, Gerhard Andersson
OBJECTIVES: Depression in elderly people is a major public health concern. As response to antidepressants is often unsatisfactory in this age group, there is a need for evidence-based non-pharmacological treatment options. Our objectives were twofold: firstly, to synthesize published trials evaluating efficacy, safety and cost-effectiveness of psychological treatment of depression in the elderly and secondly, to assess the quality of evidence. METHOD: The electronic databases PubMed, EMBASE, Cochrane Library, CINAL, Scopus, and PsycINFO were searched up to 23 May 2016 for randomized controlled trials (RCTs) of psychological treatment for depressive disorders or depressive symptoms in people aged 65 years and over...
2016: PloS One
Calin Plesa, Daniel Verschueren, Sergii Pud, Jaco van der Torre, Justus W Ruitenberg, Menno J Witteveen, Magnus P Jonsson, Alexander Y Grosberg, Yitzhak Rabin, Cees Dekker
Long DNA molecules can self-entangle into knots. Experimental techniques for observing such DNA knots (primarily gel electrophoresis) are limited to bulk methods and circular molecules below 10 kilobase pairs in length. Here, we show that solid-state nanopores can be used to directly observe individual knots in both linear and circular single DNA molecules of arbitrary length. The DNA knots are observed as short spikes in the nanopore current traces of the traversing DNA molecules and their detection is dependent on a sufficiently high measurement resolution, which can be achieved using high-concentration LiCl buffers...
August 15, 2016: Nature Nanotechnology
Ann I Larsson, Lena M Granhag, Per R Jonsson
Water flow affects settlement of marine larvae on several scales. At the smallest scale local flow regime may control the probability of adhesion to the substrate. Our aim was to mechanistically understand the transition from suspended to attached larvae in turbulent flow. Recently it was proposed that opportunities for larval settlement in turbulent boundary layers depend on time windows with suitable instantaneous flow properties. In flume flow we characterized the proportion of suitable time windows in a series of flow velocities with focus on the near-bed flow...
2016: PloS One
David Fredman, Leif Svensson, Yifang Ban, Martin Jonsson, Jacob Hollenberg, Per Nordberg, Mattias Ringh, Mårten Rosenqvist, Margareta Lundén, Andreas Claesson
INTRODUCTION: Early use of automated external defibrillators (AED) increases survival in cases of out-of-hospital cardiac arrest (OHCA). Dispatchers play important roles in identifying OHCA, dispatching ambulances and providing callers with telephone-assisted cardiopulmonary resuscitation. Guidelines recommend that AED registries be linked to dispatch centres as tools to refer callers to nearby AED. AIM: The aim of this study was to investigate to what extent dispatchers, when provided with a tool to display AED locations and accessibility, referred callers to nearby AED...
October 2016: Resuscitation
Anne Tham, Ulf Jonsson, Gerhard Andersson, Anne Söderlund, Per Allard, Göran Bertilsson
BACKGROUND: There has been a steady increase in the prescription of antidepressants for the elderly. This study comprises a systematic review of randomized, placebo-controlled trials of antidepressants for treatment of depressive disorder in people aged 65 years or more. METHODS: PubMed, EMBASE, Cochrane Library, CINAL, and PsycINFO were searched until May 2016. Where appropriate, the results were synthesized in meta-analyses. RESULTS: Twelve trials met the inclusion criteria...
November 15, 2016: Journal of Affective Disorders
Knud Andreas Jønsson, Kaspar Delhey, George Sangster, Per G P Ericson, Martin Irestedt
Observations by Alfred Wallace and Jared Diamond of plumage similarities between co-occurring orioles (Oriolus) and friarbirds (Philemon) in the Malay archipelago led them to conclude that the former represent visual mimics of the latter. Here, we use molecular phylogenies and plumage reflectance measurements to test several key predictions of the mimicry hypothesis. We show that friarbirds originated before brown orioles, that the two groups did not co-speciate, although there is one plausible instance of co-speciation among species on the neighbouring Moluccan islands of Buru and Seram...
June 29, 2016: Proceedings. Biological Sciences
Satish Babu Moparthi, Uno Carlsson, Renaud Vincentelli, Bengt-Harald Jonsson, Per Hammarström, Jérôme Wenger
Here, we study and compare the mechanisms of action of the GroEL/GroES and the TRiC chaperonin systems on MreB client protein variants extracted from E. coli. MreB is a homologue to actin in prokaryotes. Single-molecule fluorescence correlation spectroscopy (FCS) and time-resolved fluorescence polarization anisotropy report the binding interaction of folding MreB with GroEL, GroES and TRiC. Fluorescence resonance energy transfer (FRET) measurements on MreB variants quantified molecular distance changes occurring during conformational rearrangements within folding MreB bound to chaperonins...
2016: Scientific Reports
Frida Jonsson, Miguel San Sebastian, Lotta M J Strömsten, Anne Hammarström, Per E Gustafsson
While research examining the health impact of early socioeconomic conditions suggests that effects may exist independently of or jointly with adult socioeconomic position, studies exploring other potential pathways are few. Following a chain of risk life course model, this prospective study seeks to examine whether pathways of occupational class as well as material and social adversities across the life course link socioeconomic disadvantage in adolescent to functional somatic symptoms in mid-adulthood. Applying path analysis, a multiple mediator model was assessed using prospective data collected during 26 years through the Northern Swedish Cohort...
2016: PloS One
T M Davison, N N Jonsson, D G Mayer, J B Gaughan, W K Ehrlich, M R McGowan
Exposure to hot environments affects milk yield (MY) and milk composition of pasture and feed-pad fed dairy cows in subtropical regions. This study was undertaken during summer to compare MY and physiology of cows exposed to six heat-load management treatments. Seventy-eight Holstein-Friesian cows were blocked by season of calving, parity, milk yield, BW, and milk protein (%) and milk fat (%) measured in 2 weeks prior to the start of the study. Within blocks, cows were randomly allocated to one of the following treatments: open-sided iron roofed day pen adjacent to dairy (CID) + sprinklers (SP); CID only; non-shaded pen adjacent to dairy + SP (NSD + SP); open-sided shade cloth roofed day pen adjacent to dairy (SCD); NSD + sprinkler (sprinkler on for 45 min at 1100 h if mean respiration rate >80 breaths per minute (NSD + WSP)); open-sided shade cloth roofed structure over feed bunk in paddock + 1 km walk to and from the dairy (SCP + WLK)...
May 12, 2016: International Journal of Biometeorology
Babak Hooshmand, Francesca Mangialasche, Grégoria Kalpouzos, Alina Solomon, Ingemar Kåreholt, A David Smith, Helga Refsum, Rui Wang, Marc Mühlmann, Birgit Ertl-Wagner, Erika Jonsson Laukka, Lars Bäckman, Laura Fratiglioni, Miia Kivipelto
IMPORTANCE: Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia. OBJECTIVE: To investigate the association of circulating levels of vitamin B12, red blood cell folate, and sulfur amino acids with the rate of total brain volume loss and the change in white matter hyperintensity volume as measured by fluid-attenuated inversion recovery in older adults. DESIGN, SETTING, AND PARTICIPANTS: The magnetic resonance imaging subsample of the Swedish National Study on Aging and Care in Kungsholmen, a population-based longitudinal study in Stockholm, Sweden, was conducted in 501 participants aged 60 years or older who were free of dementia at baseline...
June 1, 2016: JAMA Psychiatry
Valerie M Harris, Rohan Sharma, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Astrid Rasmussen, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Marta E Alarcon-Riquelme, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Wan-Fai Ng, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, Torsten Witte, Xavier Mariette, Christopher J Lessard, John B Harley, Kathy L Sivils, R Hal Scofield
Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS)...
July 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Marcela Jirón, Virginia Pate, Laura C Hanson, Jennifer L Lund, Michele Jonsson Funk, Til Stürmer
OBJECTIVES: To estimate the prevalence and determinants of the use of potentially inappropriate medications (PIMs) in older U.S. adults using the 2012 Beers criteria. DESIGN: Retrospective cohort study in a random national sample of Medicare beneficiaries. SETTING: Fee-for-service Medicare beneficiaries from 2007 to 2012. PARTICIPANTS: U.S. population aged 65 and older with Parts A, B, and D enrollment in at least 1 month during a calendar year (N = 38,250 individuals; 1,308,116 observations)...
April 2016: Journal of the American Geriatrics Society
Boon Q Lee, Hooshang Nikjoo, Jörgen Ekman, Per Jönsson, Andrew E Stuchbery, Tibor Kibédi
To benchmark a Monte Carlo model of the Auger cascade that has been developed at the Australian National University (ANU) against the literature data. The model is applicable to any Auger-electron emitting radionuclide with nuclear structure data in the format of the Evaluated Nuclear Structure Data File (ENSDF). Schönfeld's algorithms and the BrIcc code were incorporated to obtain initial vacancy distributions due to electron capture (EC) and internal conversion (IC), respectively. Atomic transition probabilities were adopted from the Evaluated Atomic Data Library (EADL) for elements with atomic number, Z = 1-100...
March 24, 2016: International Journal of Radiation Biology
Daniel H Shain, Katrín Halldórsdóttir, Finnur Pálsson, Guðfinna Aðalgeirsdóttir, Andri Gunnarsson, Þorsteinn Jónsson, Shirley A Lang, Hlynur Skagfjörð Pálsson, Sveinbjörn Steinþórssson, Einar Arnason
Very few animal taxa are known to reside permanently in glacier ice/snow. Here we report the widespread colonization of Icelandic glaciers and ice fields by species of bdelloid Rotifera. Specimens were collected within the accumulation zones of Langjökull and Vatnajökull ice caps, among the largest European ice masses. Rotifers reached densities up to ∼100 individuals per liter-equivalent of glacier ice/snow, and were freeze-tolerant. Phylogenetic analyses indicate that glacier rotifers are polyphyletic, with independent ancestries occurring within the Pleistocene...
May 2016: Molecular Phylogenetics and Evolution
Patrick Micke, Johanna Sofia Margareta Mattsson, Dijana Djureinovic, Björn Nodin, Karin Jirström, Lena Tran, Per Jönsson, Maria Planck, Johan Botling, Hans Brunnström
INTRODUCTION: Histopathological classification of lung cancer is of central importance in the diagnostic routine, and it guides therapy in most patients. The fourth edition of the World Health Organization (WHO) Classification of Lung Tumours was recently published and includes changes to the diagnostic procedure for non-small cell carcinomas (NSCCs), with more emphasis on immunohistochemical (IHC) staining. METHODS: A total of 656 unselective cases of resected pulmonary NSCC were diagnosed according to the 2004 WHO classification...
June 2016: Journal of Thoracic Oncology
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