keyword
https://read.qxmd.com/read/38656687/combining-population-genomics-and-biophysical-modelling-to-assess-connectivity-patterns-in-an-antarctic-fish
#1
JOURNAL ARTICLE
Valentina Bernal-Durán, David Donoso, Andrea Piñones, Per R Jonsson, Laura Benestan, Mauricio F Landaeta, Javier Naretto, Karin Gerard, Pilar A Haye, Claudio Gonzalez-Wevar, Elie Poulin, Nicolás I Segovia
Connectivity is a fundamental process of population dynamics in marine ecosystems. In the last decade, with the emergence of new methods, combining different approaches to understand the patterns of connectivity among populations and their regulation has become increasingly feasible. The Western Antarctic Peninsula (WAP) is characterized by complex oceanographic dynamics, where local conditions could act as barriers to population connectivity. Here, the notothenioid fish Harpagifer antarcticus, a demersal species with a complex life cycle (adults with poor swim capabilities and pelagic larvae), was used to assess connectivity along the WAP by combining biophysical modelling and population genomics methods...
April 24, 2024: Molecular Ecology
https://read.qxmd.com/read/38580345/the-hla-region-in-anca-associated-vasculitis-characterisation-of-genetic-associations-in-a-scandinavian-patient-population
#2
JOURNAL ARTICLE
Christian Lundtoft, Ann Knight, Jennifer R S Meadows, Åsa Karlsson, Solbritt Rantapää-Dahlqvist, Ewa Berglin, Øyvind Palm, Hilde Haukeland, Iva Gunnarsson, Annette Bruchfeld, Mårten Segelmark, Sophie Ohlsson, Aladdin J Mohammad, Per Eriksson, Peter Söderkvist, Lars Ronnblom, Roald Omdal, Roland Jonsson, Kerstin Lindblad-Toh, Johanna Dahlqvist
OBJECTIVE: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are inflammatory disorders with ANCA autoantibodies recognising either proteinase 3 (PR3-AAV) or myeloperoxidase (MPO-AAV). PR3-AAV and MPO-AAV have been associated with distinct loci in the human leucocyte antigen (HLA) region. While the association between MPO-AAV and HLA has been well characterised in East Asian populations where MPO-AAV is more common, studies in populations of European descent are limited...
April 4, 2024: RMD Open
https://read.qxmd.com/read/38555430/associations-between-dietary-behaviours-and-the-mental-and-physical-well-being-of-swedish-adolescents
#3
JOURNAL ARTICLE
Kenisha Russell Jonsson, Cameron Kymani Bailey, Maria Corell, Petra Löfstedt, Nicholas Kofi Adjei
AIMS: This study aims to investigate the association between dietary behaviours, overweight/obesity, and mental health and well-being among Swedish adolescents. METHODS: Data from the 2017/2018 Health Behaviour in School-aged Children (HBSC) survey of 3692 adolescents aged ≈11, ≈13, and ≈15 years was analysed. We evaluated the prevalence and association of dietary behaviours, characterised by daily intake of fruits and vegetables, consumption of sugar-sweetened beverages (SSBs) and sweets once per week, and daily consumption of family meals and breakfast, with socioeconomic and demographic factors...
March 30, 2024: Child and Adolescent Psychiatry and Mental Health
https://read.qxmd.com/read/38489354/resolving-the-slip-rate-inconsistency-of-the-northern-dead-sea-fault
#4
JOURNAL ARTICLE
Xing Li, Sigurjón Jónsson, Shaozhuo Liu, Zhangfeng Ma, Nicolás Castro-Perdomo, Simone Cesca, Frédéric Masson, Yann Klinger
Reported fault slip rates, a key quantity for earthquake hazard and risk analyses, have been inconsistent for the northern Dead Sea fault (DSF). Studies of offset geological and archeological structures suggest a slip rate of 4 to 6 millimeters per year, consistent with the southern DSF, whereas geodetic slip-rate estimates are only 2 to 3 millimeters per year. To resolve this inconsistency and overcome limited access to the northern DSF in Syria, we here use burst-overlap interferometric time-series analysis of satellite radar images to provide an independent slip-rate estimate of ~2...
March 15, 2024: Science Advances
https://read.qxmd.com/read/38445487/compression-only-or-standard-cardiopulmonary-resuscitation-for-trained-laypersons-in-out-of-hospital-cardiac-arrest-a-nationwide-randomized-trial-in-sweden
#5
JOURNAL ARTICLE
Gabriel Riva, Erik Boberg, Mattias Ringh, Martin Jonsson, Andreas Claesson, Anette Nord, Sten Rubertsson, Hans Blomberg, Per Nordberg, Sune Forsberg, Mårten Rosenqvist, Leif Svensson, Cecilia Andréll, Johan Herlitz, Jacob Hollenberg
BACKGROUND: The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest. This pilot study assesses feasibility, safety, and intermediate clinical outcomes as part of the larger TANGO2 survival trial. METHODS: Emergency medical dispatch calls of suspected out-of-hospital cardiac arrest were screened for inclusion at 18 dispatch centers in Sweden between January 1, 2017, and March 12, 2020...
March 6, 2024: Circulation. Cardiovascular Quality and Outcomes
https://read.qxmd.com/read/38417773/the-design-of-the-princess-2-trial-a-randomized-trial-to-study-the-impact-of-ultrafast-hypothermia-on-complete-neurologic-recovery-after-out-of-hospital-cardiac-arrest-with-initial-shockable-rhythm
#6
JOURNAL ARTICLE
Emelie Dillenbeck, Jacob Hollenberg, Michael Holzer, Hans-Jörg Busch, Graham Nichol, Peter Radsel, Jan Belohlavec, Ervigio Corral Torres, Esteban López-de-Sa, Fernando Rosell, Giuseppe Ristagno, Sune Forsberg, Filippo Annoni, Leif Svensson, Martin Jonsson, Denise Bäckström, Mikael Gellerfors, Akil Awad, Fabio S Taccone, Per Nordberg
BACKGROUND: Delayed hypothermia, initiated after hospital arrival, several hours after cardiac arrest with 8-10 hours to reach the target temperature, is likely to have limited impact on overall survival. However, the effect of ultrafast hypothermia, i.e., delivered intra-arrest or immediately after return of spontaneous circulation (ROSC), on functional neurologic outcome after out-of-hospital cardiac arrest (OHCA) is unclear. In two prior trials, prehospital trans-nasal evaporative intra-arrest cooling was safe, feasible and reduced time to target temperature compared to delayed cooling...
February 28, 2024: American Heart Journal
https://read.qxmd.com/read/38405768/fine-mapping-genomic-loci-refines-bipolar-disorder-risk-genes
#7
Maria Koromina, Ashvin Ravi, Georgia Panagiotaropoulou, Brian M Schilder, Jack Humphrey, Alice Braun, Tim Bidgeli, Chris Chatzinakos, Brandon Coombes, Jaeyoung Kim, Xiaoxi Liu, Chikashi Terao, Kevin S O 'Connell, Mark Adams, Rolf Adolfsson, Martin Alda, Lars Alfredsson, Till F M Andlauer, Ole A Andreassen, Anastasia Antoniou, Bernhard T Baune, Susanne Bengesser, Joanna Biernacka, Michael Boehnke, Rosa Bosch, Murray Cairns, Vaughan J Carr, Miquel Casas, Stanley Catts, Sven Cichon, Aiden Corvin, Nicholas Craddock, Konstantinos Dafnas, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Dimitris Dikeos, Frederike Tabea Fellendorf, Panagiotis Ferentinos, Andreas J Forstner, Liz Forty, Mark Frye, Janice M Fullerton, Micha Gawlik, Ian R Gizer, Katherine Gordon-Smith, Melissa J Green, Maria Grigoroiu-Serbanescu, José Guzman-Parra, Tim Hahn, Frans Henskens, Jan Hillert, Assen V Jablensky, Lisa Jones, Ian Jones, Lina Jonsson, John R Kelsoe, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Manolis Kogevinas, Mikael Landén, Marion Leboyer, Melanie Lenger, Jolanta Lissowska, Christine Lochner, Carmel Loughland, Donald MacIntyre, Nicholas G Martin, Eirini Maratou, Carol A Mathews, Fermin Mayoral, Susan L McElroy, Nathaniel W McGregor, Andrew McIntosh, Andrew McQuillin, Patricia Michie, Vihra Milanova, Philip B Mitchell, Paraskevi Moutsatsou, Bryan Mowry, Bertram Müller-Myhsok, Richard Myers, Igor Nenadić, Markus M Nöthen, Claire O'Donovan, Michael O'Donovan, Roel A Ophoff, Michael J Owen, Chris Pantelis, Carlos Pato, Michele T Pato, George P Patrinos, Joanna M Pawlak, Roy H Perlis, Evgenia Porichi, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Andreas Reif, Eva Z Reininghaus, Marta Ribasés, Marcella Rietschel, Ulrich Schall, Thomas G Schulze, Laura Scott, Rodney J Scott, Alessandro Serretti, Cynthia Shannon Weickert, Jordan W Smoller, Maria Soler Artigas, Dan J Stein, Fabian Streit, Claudio Toma, Paul Tooney, Eduard Vieta, John B Vincent, Irwin D Waldman, Thomas Weickert, Stephanie H Witt, Kyung Sue Hong, Masashi Ikeda, Nakao Iwata, Beata Świątkowska, Hong-Hee Won, Howard J Edenberg, Stephan Ripke, Towfique Raj, Jonathan R I Coleman, Niamh Mullins
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci, and prioritized 22 likely causal SNPs for BD. We mapped these SNPs to genes, and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci, and results from rare variant exome sequencing in BD...
February 13, 2024: medRxiv
https://read.qxmd.com/read/38370561/offering-an-auto-play-feature-likely-increases-total-gambling-activity-at-online-slot-machines-preliminary-evidence-from-an-interrupted-time-series-experiment-at-a-real-life-online-casino
#8
JOURNAL ARTICLE
Jakob Jonsson, Per Carlbring, Philip Lindner
Auto-play is a ubiquitous feature in online casino gambling and virtual slot machines especially, allowing gamblers to initiate spin sequences of pre-set length and value. While theoretical accounts diverge on the hypothesized causal effect on gambling behavior of using the auto-play feature, observational findings show that this feature is used to a higher degree by problem and/or high-intensity gamblers, suggesting that banning this feature may constitute a global responsible gambling measure. Direct, experimental research on causal effects of offering auto-play at online casinos is however lacking...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38268848/outline-and-validation-of-a-new-dispatcher-assisted-cardiopulmonary-resuscitation-educational-bundle-using-the-delphi-method
#9
JOURNAL ARTICLE
Andreas Claesson, Håkan Hult, Gabriel Riva, Fredrik Byrsell, Thomas Hermansson, Leif Svensson, Therese Djärv, Mattias Ringh, Per Nordberg, Martin Jonsson, Sune Forsberg, Jacob Hollenberg, Anette Nord
AIM: Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) is time-dependent. To date, evidence-based training programmes for dispatchers are lacking. This study aimed to reach expert consensus on an educational bundle content for dispatchers to provide DA-CPR using the Delphi method. METHOD: An educational bundle was created by the Swedish Resuscitation Council consisting of three parts: e-learning on DA-CPR, basic life support training and audit of emergency out-of-hospital cardiac arrest calls...
March 2024: Resuscitation plus
https://read.qxmd.com/read/38268066/safety-and-efficacy-of-blood-flow-restriction-exercise-in-individuals-with-neurological-disorders-a-systematic-review
#10
REVIEW
Anette Bach Jønsson, Søren Krogh, Henrik Sehested Laursen, Per Aagaard, Helge Kasch, Jørgen Feldbaek Nielsen
OBJECTIVES: This systematic review evaluated the safety and efficacy of blood flow restriction exercise (BFRE) on skeletal muscle size, strength, and functional performance in individuals with neurological disorders (ND). METHODS: A literature search was performed in PubMed, CINAHL, and Embase. Two researchers independently assessed eligibility and performed data extraction and quality assessments. ELIGIBILITY CRITERIA: Study populations with ND, BFRE as intervention modality, outcome measures related to safety or efficacy...
January 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38230728/estimates-of-current-capacity-for-diagnosing-alzheimer-s-disease-in-sweden-and-the-need-to-expand-specialist-numbers
#11
JOURNAL ARTICLE
S Mattke, A Gustavsson, L Jacobs, S Kern, S N Palmqvist, M Eriksdotter, I Skoog, B Winblad, A Wimo, L Jönsson
BACKGROUND: The emergence of disease-modifying Alzheimer's (AD) treatments provides new hope to patients and families but concerns have been raised about the preparedness of healthcare systems to provide timely access to such treatments because of a combination of a complex diagnostic process and a large prevalent pool. OBJECTIVES: We assess the preparedness of Sweden, a high-income country known for its dementia-friendly policies, to diagnose AD patients eligible for treatment within a six-month window, given current capacity for specialist evaluations and biomarker testing...
2024: Journal of Prevention of Alzheimer's Disease
https://read.qxmd.com/read/38094114/multicenter-registry-and-test-bed-for-extended-outpatient-hemodynamic-monitoring-the-hemodynamic-frontiers-in-heart-failure-hf-2-initiative
#12
JOURNAL ARTICLE
J Thomas Heywood, Kartik Munshi, Timothy Jordan, Evan Muse, Marat Fudim, Andrew J Sauer, Margaret McDermott, Hirak Shah, Arvind Bhimaraj, Rola Khedraki, Monique R Robinson, Patrick McCann, Elizabeth Volz, Ashrith Guha, Orvar Jonsson, Kunjan A Bhatt, Mosi K Bennett, Terrie Ann Benjamin, Maya Guglin, Jacob Abraham
BACKGROUND: Hemodynamic Frontiers in Heart Failure (HF2 ) is a multicenter academic research consortium comprised of 14 US institutions with mature remote monitoring programs for ambulatory patients with heart failure (HF). The consortium developed a retrospective and prospective registry of patients implanted with a wireless pulmonary artery pressure (PAP) sensor. GOALS/AIMS: HF2 registry collects demographic, clinical, laboratory, echocardiographic (ECHO), and hemodynamic data from patients with PAP sensors...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38081809/the-formation-of-the-indo-pacific-montane-avifauna
#13
JOURNAL ARTICLE
Andrew Hart Reeve, Jonathan David Kennedy, José Martín Pujolar, Bent Petersen, Mozes P K Blom, Per Alström, Tri Haryoko, Per G P Ericson, Martin Irestedt, Johan A A Nylander, Knud Andreas Jønsson
The processes generating the earth's montane biodiversity remain a matter of debate. Two contrasting hypotheses have been advanced to explain how montane populations form: via direct colonization from other mountains, or, alternatively, via upslope range shifts from adjacent lowland areas. We seek to reconcile these apparently conflicting hypotheses by asking whether a species' ancestral geographic origin determines its mode of mountain colonization. Island-dwelling passerine birds at the faunal crossroads between Eurasia and Australo-Papua provide an ideal study system...
December 11, 2023: Nature Communications
https://read.qxmd.com/read/38000871/drone-delivery-of-automated-external-defibrillators-compared-with-ambulance-arrival-in-real-life-suspected-out-of-hospital-cardiac-arrests-a-prospective-observational-study-in-sweden
#14
JOURNAL ARTICLE
Sofia Schierbeck, Anette Nord, Leif Svensson, Mattias Ringh, Per Nordberg, Jacob Hollenberg, Peter Lundgren, Fredrik Folke, Martin Jonsson, Sune Forsberg, Andreas Claesson
BACKGROUND: A novel approach to improve bystander defibrillation for out-of-hospital cardiac arrests is to dispatch and deliver an automated external defibrillator (AED) directly to the suspected cardiac arrest location by drone. The aim of this study was to investigate how often a drone could deliver an AED before ambulance arrival and to measure the median time benefit achieved by drone deliveries. METHODS: In this prospective observational study, five AED-equipped drones were placed within two separate controlled airspaces in Sweden, covering approximately 200 000 inhabitants...
December 2023: The Lancet. Digital health
https://read.qxmd.com/read/37964753/a-model-based-approach-leveraging-in%C3%A2-vitro-data-to-support-dose-selection-from-the-outset-a-framework-for-bispecific-antibodies-in-immuno-oncology
#15
JOURNAL ARTICLE
Javier Sánchez, Christina Claus, Rosmarie Albrecht, Brenda C Gaillard, Joana Marinho, Christine McIntyre, Tamara Tanos, Axel Boehnke, Lena E Friberg, Siv Jönsson, Nicolas Frances
FAP-4-1BBL is a bispecific antibody exerting 4-1BB-associated T-cell activation only while simultaneously bound to the fibroblast activation protein (FAP) receptor, expressed on the surface of cancer-associated fibroblasts. The trimeric complex formed when FAP-4-1BBL is simultaneously bound to FAP and 4-1BB represents a promising mechanism to achieve tumor-specific 4-1BB stimulation. We integrated in vitro data with mathematical modeling to characterize the pharmacology of FAP-4-1BBL as a function of trimeric complex formation when combined with the T-cell engager cibisatamab...
November 15, 2023: CPT: Pharmacometrics & Systems Pharmacology
https://read.qxmd.com/read/37962887/cardiovascular-outcomes-of-%C3%AE-blockers-vs-5-%C3%AE-reductase-inhibitors-for-benign-prostatic-hyperplasia
#16
JOURNAL ARTICLE
Jiandong Zhang, Chase D Latour, Oluwasolape Olawore, Virginia Pate, David F Friedlander, Til Stürmer, Michele Jonsson Funk, Brian C Jensen
IMPORTANCE: The most prescribed class of medications for benign prostatic hyperplasia (BPH) is α-blockers (ABs). However, the cardiovascular safety profile of these medications among patients with BPH is not well understood. OBJECTIVE: To compare the safety of ABs vs 5-α reductase inhibitors (5-ARIs) for risk of adverse cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS: This active comparator, new-user cohort study was conducted using insurance claims data from a 20% random sample of Medicare beneficiaries from 2007 to 2019 to evaluate the 1-year risk of adverse cardiovascular outcomes...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37875678/growing-rods-in-meningomyelocele-lead-to-increased-risk-for-complications-in-comparison-with-fusion-a-retrospective-study-of-30-patients-treated-for-at-the-university-hospital-of-uppsala
#17
JOURNAL ARTICLE
Michael G Kontakis, Konstantinos Pazarlis, Thomas Karlsson, Håkan Jonsson, Nikos Schizas
PURPOSE: To compare the complication rates of two different types of posterior instrumentation in patients with MMC, namely, definitive fusion and fusionless surgery (growing rods). METHODS: Single-center retrospective study of 30 MMC patients that underwent posterior instrumentation for deformity (scoliosis and/or kyphosis) treatment from 2008 until 2020. The patients were grouped based on whether they received definitive fusion or a growth-accommodating system, whether they had a complication that led to early surgery, osteotomy or non-osteotomy...
October 24, 2023: European Spine Journal
https://read.qxmd.com/read/37868143/low-levels-of-endogenous-anabolic-androgenic-steroids-in-females-with-severe-asthma-taking-corticosteroids
#18
JOURNAL ARTICLE
Valentyna Yasinska, Cristina Gómez, Johan Kolmert, Magnus Ericsson, Anton Pohanka, Anna James, Lars I Andersson, Maria Sparreman-Mikus, Ana R Sousa, John H Riley, Stewart Bates, Per S Bakke, Nazanin Zounemat Kermani, Massimo Caruso, Pascal Chanez, Stephen J Fowler, Thomas Geiser, Peter H Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E Shaw, Richard G Knowles, Barbro Dahlén, Anke-Hilse Maitland-van der Zee, Peter J Sterk, Ratko Djukanovic, Ian M Adcock, Kian Fan Chung, Craig E Wheelock, Sven-Erik Dahlén, Eva Wikström Jonsson
RATIONALE: Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure. METHODS: Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry...
September 2023: ERJ Open Research
https://read.qxmd.com/read/37839812/breakthrough-covid-19-after-tixagevimab-cilgavimab-among-patients-with-systemic-autoimmune-rheumatic-diseases
#19
JOURNAL ARTICLE
Yumeko Kawano, Xiaosong Wang, Naomi J Patel, Grace Qian, Emily Kowalski, Katarina J Bade, Kathleen M M Vanni, A Helena Jonsson, Zachary K Williams, Shruthi Srivatsan, Claire E Cook, Zachary S Wallace, Jeffrey A Sparks
OBJECTIVE: To determine the incidence and baseline factors associated with breakthrough COVID-19 after pre-exposure prophylaxis (PrEP) with tixagevimab/cilgavimab among patients with systemic autoimmune rheumatic diseases (SARDs). METHODS: We performed a retrospective cohort study among patients with SARDs who received tixagevimab/cilgavimab between January 2, 2022 and November 16, 2022. The primary outcome was breakthrough COVID-19 after tixagevimab/cilgavimab...
October 15, 2023: Journal of Rheumatology
https://read.qxmd.com/read/37822115/adolescents-self-reported-experiences-following-a-person-centred-theory-based-educational-intervention-versus-conventional-education-for-improved-oral-hygiene-analysis-of-secondary-outcomes-of-a-randomized-field-study
#20
RANDOMIZED CONTROLLED TRIAL
Sandra L Dimenäs, Jessica S Andersson, Birgitta Jönsson, Jesper Lundgren, Max Petzold, Anna-Lena Östberg, Kajsa H Abrahamsson
AIM: To analyse adolescents' self-reported experiences and behavioural outcomes of a person-centred, theory-based intervention in comparison with conventional information/instruction for improved oral hygiene. MATERIALS AND METHODS: Data were derived from a prospective, multi-centred, two-arm, quasi-randomized field study focusing on the effectiveness of educational interventions for improved oral hygiene. Dental hygienists working within the Public Dental Service, Västra Götaland, Sweden, provided treatments, and adolescents with poor oral hygiene conditions were eligible for participation...
January 2024: Journal of Clinical Periodontology
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