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Per Jonsson

Per Davidson, Ingegerd Carlsson, Peter Jönsson, Mikael Johansson
The aim of this study was to examine how a daytime nap affected the consolidation of fear learning. Participants first underwent fear conditioning during which they were exposed to a large and a small circle. One of these was repeatedly paired with an electric shock (making it the CS+), whereas the other circle was never paired with the shock (the CS-). After a delay interval containing either a nap or wake, participants again viewed the CS+ and the CS- intermixed with eight novel circles that varied in size between the two stimuli seen before, as well as a blue triangle that served as a novel stimulus without prior fear relevance...
March 15, 2018: Neurobiology of Learning and Memory
Siobhán Masterson, Bryan McNally, John Cullinan, Kimberly Vellano, Joséphine Escutnaire, David Fitzpatrick, Gavin D Perkins, Rudolph W Koster, Yuko Nakajima, Katherine Pemberton, Martin Quinn, Karen Smith, Bergþór Steinn Jónsson, Anneli Strömsöe, Meera Tandan, Akke Vellinga
BACKGROUND: The highest achievable survival rate following out-of-hospital cardiac arrest is unknown. Data from airports serving international destinations (international airports) provide the opportunity to evaluate the success of pre-hospital resuscitation in a relatively controlled but real-life environment. METHODS: This retrospective cohort study included all cases of out-of-hospital cardiac arrest at international airports with resuscitation attempted between January 1st, 2013 and December 31st, 2015...
March 14, 2018: Resuscitation
Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E Weeke, Marit E Jørgensen, Kristine Færch, Daniel R Witte, Jens J Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K Kanters, Torben Hansen
BACKGROUND: Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused by a dysfunctional Kv11.1 voltage-gated potassium channel. Based on these findings in patients with rare variants in hERG, we hypothesized that common variants in hERG may also lead to alterations in glucose homeostasis...
March 16, 2018: BMC Genetics
Per Jonsson, Lorentz Lindmark, Jan Axelsson, Lars Karlsson, Lennart Lundberg, Bernd Stegmayr
We were encouraged to investigate the reasons for large amounts of foam observed in bloodlines during hemodialysis (HD). Foam was visible in the venous air trap within the Artis Gambro dialysis device. Estimates of the extent of foam were graded (0-no foam, 10-extensive foam) by two persons that were blind to the type of dialyzer used. Thirty-seven patients were involved in the dialysis procedures. Consecutive dialyses were graded using dialyzers from Fresenius Medical Care (CorDiax dialyzers that were used for high flux HD-FX80 and FX100, and for hemodiafiltration-FX1000)...
March 15, 2018: Artificial Organs
Daniela A Grassi, Marie E Jönsson, Per Ludvik Brattås, Johan Jakobsson
TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain...
March 6, 2018: Brain Research
Filip Nilsson, Åsa Davidsson, Per Falås, Simon Bengtsson, Kai Bester, Karin Jönsson
Ozone was applied to return activated sludge in full-scale to study how ozone impacts filamentous bacteria viability (Live/Dead® ). Additionally, the ozonated sludges were subjected to anaerobic digestion trials and analysis of micropollutants. Ozone treatment (3-4.8 g O3 /kg TSS) improved the settling properties of the sludge by lowering the diluted sludge volume with 7-35%. Ozone inactivated filamentous bacteria outside the floc structures and the fraction of inactivated filaments increased with an increasing ozone dose...
February 28, 2018: Environmental Technology
Göran M Ahlgren, Per Flodgren, Teuvo L J Tammela, Pirkko Kellokumpu-Lehtinen, Michael Borre, Anders Angelsen, Jon Reidar Iversen, Asgerdur Sverrisdottir, Eirikur Jonsson, Lisa Sengelov
BACKGROUND: Adjuvant chemotherapy is standard treatment for other solid tumours, but to date has not proven effective in prostate cancer. OBJECTIVE: o evaluate whether six cycles of docetaxel alone improve biochemical disease-free survival after radical prostatectomy for high-risk prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: Open-label, randomised multinational phase 3 trial. Enrolment of 459 patients after prostatectomy. INCLUSION CRITERIA: high-risk pT2 margin positive or pT3a Gleason score ≥4+3, pT3b, or lymph node positive disease Gleason score ≥3+4...
January 27, 2018: European Urology
Kamil Kosiel, Magdalena Dominik, Iga Ściślewska, Małgorzata Kalisz, Marek Guziewicz, Krystyna Gołaszewska, Joanna Niedziółka-Jonsson, Wojtek J Bock, Mateusz J Smietana
The paper presents investigation of properties of selected metallic oxides deposited at low temperature (100°C) by atomic layer deposition (ALD) technique, relating to their applicability as thin overlays for optical fiber sensors resistant in alkaline environments. Hafnium oxide (Hf<sub>x</sub>O<sub>y</sub> with y/x approx. 2.70), tantalum oxide (Ta<sub>x</sub>O<sub>y</sub> with y/x approx. 2.75) and zirconium oxide (Zr<sub>x</sub>O<sub>y</sub> with y/x approx...
January 22, 2018: Nanotechnology
Tufve Nyholm, Stina Svensson, Sebastian Andersson, Joakim Jonsson, Maja Sohlin, Christian Gustafsson, Elisabeth Kjellén, Karin Söderström, Per Albertsson, Lennart Blomqvist, Björn Zackrisson, Lars E Olsson, Adalsteinn Gunnlaugsson
PURPOSE: We describe a public dataset with MR and CT images of patients performed in the same position with both multi observer and expert consensus delineations of relevant organs in the male pelvic region. The purpose is to provide means for training and validation of segmentation algorithms and methods to convert MR to CT like data, i.e., so called synthetic CT (sCT). ACQUISITION AND VALIDATION METHODS: T1 and T2 weighted MR images as well as CT data was collected for 19 patients at three different departments...
January 11, 2018: Medical Physics
Alan C Kinlaw, Michele Jonsson Funk, Mitchell M Conover, Virginia Pate, Alayne D Markland, Jennifer M Wu
BACKGROUND: Despite several new medications being Food and Drug Administration-approved for overactive bladder (OAB) and new prescription drug payment programs, there are limited population-based data regarding OAB medication use among older adults. OBJECTIVES: To examine: (1) impacts of new medications and $4 generic programs on time trends for OAB-related medication dispensing for older adults in the United States; (2) differences by age and sex; and (3) temporal changes in OAB-related medication payments...
December 28, 2017: Medical Care
Hanna Gyllensten, Anna K Jönsson, Katja M Hakkarainen, Staffan Svensson, Staffan Hägg, Clas Rehnberg
OBJECTIVES: To estimate how direct health care costs resulting from adverse drug events (ADEs) and cost distribution are affected by methodological decisions regarding identification of ADEs, assigning relevant resource use to ADEs, and estimating costs for the assigned resources. METHODS: ADEs were identified from medical records and diagnostic codes for a random sample of 4970 Swedish adults during a 3-month study period in 2008 and were assessed for causality...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Mary Adjeiwaah, Mikael Bylund, Josef A Lundman, Camilla Thellenberg Karlsson, Joakim H Jonsson, Tufve Nyholm
PURPOSE: To investigate the effect of magnetic resonance system- and patient-induced susceptibility distortions from a 3T scanner on dose distributions for prostate cancers. METHODS AND MATERIALS: Combined displacement fields from the residual system and patient-induced susceptibility distortions were used to distort 17 prostate patient CT images. VMAT dose plans were initially optimized on distorted CT images and the plan parameters transferred to the original patient CT images to calculate a new dose distribution...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Kai Wang, Per Jönsson, Jörgen Ekman, Tomas Brage, Chong Yang Chen, Charlotte Froese Fischer, Gediminas Gaigalas, Michel Godefroid
A Comment on the Letter by Mendoza and Bautista [Phys. Rev. Lett. 118, 163002 (2017)PRLTAO0031-900710.1103/PhysRevLett.118.163002].
November 3, 2017: Physical Review Letters
Knud Andreas Jønsson, Mozes P K Blom, Martin Päckert, Per G P Ericson, Martin Irestedt
Molecular studies have revealed a number of cases in which traditional assessments of evolutionary relationships have been incorrect. This has implications not only for systematics and taxonomy but also for our understanding of how diversity patterns on Earth have been formed. Here, we use high-throughput sequencing technology to obtain molecular data from the holotype specimen of the elusive Eutrichomyias rowleyi, which is endemic to the Indonesian island of Sangihe. We show that E. rowleyi unexpectedly is a member of the family Lamproliidae, which dates back some 20 Million years and only include two other species, Lamprolia victoriae from Fiji and Chaetorhynchus papuensis from New Guinea...
March 2018: Molecular Phylogenetics and Evolution
Dat T Tran, Ilke Akpinar, Richard Fedorak, Egon Jonsson, John Mackey, Lawrence Richer, Philip Jacobs
In pharmaceutical clinical trials, industrial sponsors pay for study drugs and related healthcare services. We conducted a study to determine industry's economic contribution of these trials to the Alberta healthcare system.  Methods: We used data from two trial centers for cancer and non-cancer trials at the University of Alberta. For each trial (cancer, non-cancer), we calculated the cost of drugs provided by the sponsors using the market price, the cost of clinical services, and the cost of administrative services that they paid...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Valerie M Harris, Rohan Sharma, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Astrid Rasmussen, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Marta E Alarcon-Riquelme, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Katherine A Siminovitch, Wan-Fai Ng, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, Torsten Witte, Xavier Mariette, Christopher J Lessard, John B Harley, Kathy L Sivils, R Hal Scofield
No abstract text is available yet for this article.
February 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Mirjam K de Vries, Elizabeth V Arkema, Jerker Jonsson, Judith Bruchfeld, Lennart Th Jacobsson, Johan Askling
OBJECTIVES: Rheumatoid arthritis (RA) is a risk factor for tuberculosis (TB), particularly following treatment with biologicals. Since these therapies are increasingly used in ankylosing spondylitis (AS), other types of spondyloarthritis (SpA) and psoriatic arthritis (PsA), we investigated the corresponding TB risks in these patients. METHODS: We identified individuals with AS/SpA/PsA, and non-AS/SpA/PsA comparators by linking Swedish national Patient, Population, TB and Rheumatology registers, and followed them for TB occurrence...
December 1, 2017: Arthritis Care & Research
Kristin Blom, Amir I Elshafie, Ulla-Britt Jönsson, Johan Rönnelid, Lena Douhan Håkansson, Per Venge
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil-derived neurotoxin (EDN). We hypothesized that the interactions between dendritic cells and EDN might be of importance in the disease development. Cellular content of EDN was analyzed by ELISA. The single-nucleotide polymorphisms at positions 405, 416, and 1122 in the EDN gene were analyzed by real-time PCR with TaqMan® reagents...
January 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
H Olof Jönsson, Carl Caleman, Jakob Andreasson, Nicuşor Tîmneanu
Serial femtosecond crystallography is an emerging and promising method for determining protein structures, making use of the ultrafast and bright X-ray pulses from X-ray free-electron lasers. The upcoming X-ray laser sources will produce well above 1000 pulses per second and will pose a new challenge: how to quickly determine successful crystal hits and avoid a high-rate data deluge. Proposed here is a hit-finding scheme based on detecting photons from plasma emission after the sample has been intercepted by the X-ray laser...
November 1, 2017: IUCrJ
Anna Bryndis Blondal, Anna Birna Almarsdottir, Jon Steinar Jonsson, Sveinbjorn Gizurarson
INTRODUCTION: Elderly people are a rising population in Iceland. With higher age the likelihood of drug consumption increases and thus drug therapy problems. Pharmaceutical care has been established abroad, where the pharmacist works in collaboration with other healthcare professionals to reduce patients' drug therapy problems. The aim of this research was to study the number and types of drug therapy problems of older individuals in primary care in Garðabær, by providing pharmacist-led pharmaceutical care in collaboration with general practitioners...
November 2017: Læknablađiđ
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