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Per Jonsson

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https://www.readbyqxmd.com/read/29123680/hit-detection-in-serial-femtosecond-crystallography-using-x-ray-spectroscopy-of-plasma-emission
#1
H Olof Jönsson, Carl Caleman, Jakob Andreasson, Nicuşor Tîmneanu
Serial femtosecond crystallography is an emerging and promising method for determining protein structures, making use of the ultrafast and bright X-ray pulses from X-ray free-electron lasers. The upcoming X-ray laser sources will produce well above 1000 pulses per second and will pose a new challenge: how to quickly determine successful crystal hits and avoid a high-rate data deluge. Proposed here is a hit-finding scheme based on detecting photons from plasma emission after the sample has been intercepted by the X-ray laser...
November 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/29083310/-pharmaceutical-care-at-the-primary-care-clinic-in-gar%C3%A3-ab%C3%A3-r-number-and-type-of-drug-therapy-problems-identified-among-elderly-clients
#2
Anna Bryndis Blondal, Anna Birna Almarsdottir, Jon Steinar Jonsson, Sveinbjorn Gizurarson
INTRODUCTION: Elderly people are a rising population in Iceland. With higher age the likelihood of drug consumption increases and thus drug therapy problems. Pharmaceutical care has been established abroad, where the pharmacist works in collaboration with other healthcare professionals to reduce patients' drug therapy problems. The aim of this research was to study the number and types of drug therapy problems of older individuals in primary care in Garðabær, by providing pharmacist-led pharmaceutical care in collaboration with general practitioners...
November 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29059225/adaptation-to-dislodgement-risk-on-wave-swept-rocky-shores-in-the-snail-littorina-saxatilis
#3
Guénolé Le Pennec, Roger K Butlin, Per R Jonsson, Ann I Larsson, Jessica Lindborg, Erik Bergström, Anja M Westram, Kerstin Johannesson
The periwinkle Littorina saxatilis has repeatedly evolved both a small, fragile and globose "wave ecotype" confined to wave-swept shores and a large, robust and elongated "crab ecotype" found in nearby crab-rich but less-exposed shores. This phenotypic divergence is assumed to reflect, in some part, local adaptation to wave exposure, but this hypothesis has received incomplete experimental testing. Here, we report a test of the prediction that the wave ecotype has a higher capacity to resist water flow than the crab ecotype...
2017: PloS One
https://www.readbyqxmd.com/read/29049328/ca-19-9-and-ca-125-as-potential-predictors-of-disease-recurrence-in-resectable-lung-adenocarcinoma
#4
Sofi Isaksson, Per Jönsson, Nastaran Monsef, Hans Brunnström, Pär-Ola Bendahl, Mats Jönsson, Johan Staaf, Maria Planck
OBJECTIVES: Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. MATERIAL AND METHODS: Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28978527/dispatch-of-firefighters-and-police-officers-in-out-of-hospital-cardiac-arrest-a-nationwide-prospective-cohort-trial-using-propensity-score-analysis
#5
Ingela Hasselqvist-Ax, Per Nordberg, Johan Herlitz, Leif Svensson, Martin Jonsson, Jonny Lindqvist, Mattias Ringh, Andreas Claesson, Johan Björklund, Jan-Otto Andersson, Caroline Ericson, Pär Lindblad, Lars Engerström, Mårten Rosenqvist, Jacob Hollenberg
BACKGROUND: Dispatch of basic life support-trained first responders equipped with automated external defibrillators in addition to advanced life support-trained emergency medical services personnel in out-of-hospital cardiac arrest (OHCA) has, in some minor cohort studies, been associated with improved survival. The aim of this study was to evaluate the association between basic life support plus advanced life support response and survival in OHCA at a national level. METHODS AND RESULTS: This prospective cohort study was conducted from January 1, 2012, to December 31, 2014...
October 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28959963/parental-influence-on-human-germline-de-novo-mutations-in-1-548-trios-from-iceland
#6
Hákon Jónsson, Patrick Sulem, Birte Kehr, Snaedis Kristmundsdottir, Florian Zink, Eirikur Hjartarson, Marteinn T Hardarson, Kristjan E Hjorleifsson, Hannes P Eggertsson, Sigurjon Axel Gudjonsson, Lucas D Ward, Gudny A Arnadottir, Einar A Helgason, Hannes Helgason, Arnaldur Gylfason, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Thorunn Rafnar, Mike Frigge, Simon N Stacey, Olafur Th Magnusson, Unnur Thorsteinsdottir, Gisli Masson, Augustine Kong, Bjarni V Halldorsson, Agnar Helgason, Daniel F Gudbjartsson, Kari Stefansson
The characterization of mutational processes that generate sequence diversity in the human genome is of paramount importance both to medical genetics and to evolutionary studies. To understand how the age and sex of transmitting parents affect de novo mutations, here we sequence 1,548 Icelanders, their parents, and, for a subset of 225, at least one child, to 35× genome-wide coverage. We find 108,778 de novo mutations, both single nucleotide polymorphisms and indels, and determine the parent of origin of 42,961...
September 28, 2017: Nature
https://www.readbyqxmd.com/read/28881821/radial-artery-intima-media-thickness-regresses-after-secondary-prevention-interventions-in-patients-post-acute-coronary-syndrome-and-is-associated-with-cardiac-and-kidney-biomarkers
#7
Damilola D Adingupu, Helena U Westergren, Santosh Dahgam, Ann-Cathrine Jönsson-Rylander, Juuso Blomster, Per Albertsson, Elmir Omerovic, Sara Svedlund, Li-Ming Gan
BACKGROUND: Radial artery intima-media thickness (rIMT) measured by ultra-high-resolution ultrasound is associated with increased cardiovascular risk and predicts outcomes. We performed non-invasive high-resolution ultrasound of the radial artery to investigate vascular changes in subjects presenting with acute coronary syndrome (ACS) and who had undergone percutaneous coronary intervention (PCI). PURPOSE: In the present work, we aimed to follow rIMT change over time post-acute coronary syndrome as a tool to monitor potential response to intensified medical therapy...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878712/how-game-location-affects-soccer-performance-t-pattern-analysis-of-attack-actions-in-home-and-away-matches
#8
Barbara Diana, Valentino Zurloni, Massimiliano Elia, Cesare M Cavalera, Gudberg K Jonsson, M Teresa Anguera
The influence of game location on performance has been widely examined in sport contexts. Concerning soccer, game-location affects positively the secondary and tertiary level of performance; however, there are fewer evidences about its effect on game structure (primary level of performance). This study aimed to detect the effect of game location on a primary level of performance in soccer. In particular, the objective was to reveal the hidden structures underlying the attack actions, in both home and away matches played by a top club (Serie A 2012/2013-First Leg)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28860772/factors-associated-with-failure-to-achieve-remission-and-with-relapse-after-remission-in-patients-with-major-depressive-disorder-in-the-perform-study
#9
Delphine Saragoussi, Maëlys Touya, Josep Maria Haro, Bengt Jönsson, Martin Knapp, Bastien Botrel, Ioana Florea, Henrik Loft, Benoît Rive
BACKGROUND: The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28840772/a-health-economic-lifetime-treatment-pathway-model-for-low-back-pain-in-sweden
#10
Gylfi Olafsson, Emma Jonsson, Peter Fritzell, Olle Hägg, Fredrik Borgström
AIMS: To develop a health economic model to evaluate the long-term costs and outcomes over the healthcare treatment pathway for patients with low back pain (LBP). MATERIALS AND METHODS: A health economic model, consisting of a decision tree structure with a Markov microsimulation model at the end of each branch, was created. Patients were followed from first observed clinical presentation with LBP until the age of 100 years or death. The underlying data to populate the model were based on Swedish national and regional registry data on healthcare resource use and sickness insurance in patients presenting with LBP in the Swedish region Västra Götaland during 2008-2012...
September 11, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28832440/a-profile-of-low-back-pain-treatment-and-costs-associated-with-patients-referred-to-orthopedic-specialists-in-sweden
#11
Emma Jonsson, Gylfi Olafsson, Peter Fritzell, Olle Hägg, Fredrik Borgström
STUDY DESIGN: Analysis of Swedish national and regional register data. OBJECTIVES: The aim of this study was to characterize healthcare resource utilization, productivity loss, and costs of patients with low back pain (LBP) with or without leg pain, who have been referred from primary care settings to orthopedic specialist care. SUMMARY OF BACKGROUND DATA: Register data on outpatient and inpatient care, work absence, drug prescriptions, socioeconomics, and mortality were extracted for patients visiting orthopedic specialists for LBP in the Swedish region Västra Götaland (1...
September 1, 2017: Spine
https://www.readbyqxmd.com/read/28792237/a-new-flow-through-bioassay-for-testing-low-emission-antifouling-coatings
#12
Christian Pansch, Per R Jonsson, Mattias Berglin, Emiliano Pinori, Anna-Lisa Wrange
Current antifouling (AF) technologies are based on the continuous release of biocides into the water, and consequently discharge into the environment. Major efforts to develop more environmentally friendly coatings require efficient testing in laboratory assays, followed by field studies. Barnacles are important fouling organisms worldwide, increasing hydrodynamic drag on ships and damaging coatings on underwater surfaces, and thus are extensively used as models in AF research, mostly in static, laboratory-based systems...
August 9, 2017: Biofouling
https://www.readbyqxmd.com/read/28789696/long-term-follow-up-in-primary-sj%C3%A3-gren-s-syndrome-reveals-differences-in-clinical-presentation-between-female-and-male-patients
#13
Jorge I Ramírez Sepúlveda, Marika Kvarnström, Per Eriksson, Thomas Mandl, Katrine Brække Norheim, Svein Joar Johnsen, Daniel Hammenfors, Malin V Jonsson, Kathrine Skarstein, Johan G Brun, Lars Rönnblom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Eva Baecklund, Elke Theander, Roald Omdal, Roland Jonsson, Gunnel Nordmark, Marie Wahren-Herlenius
BACKGROUND: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS. METHODS: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers...
August 8, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28750352/modelling-the-external-radiation-exposure-from-the-chernobyl-fallout-using-data-from-the-swedish-municipality-measurement-system
#14
Mattias Jönsson, Martin Tondel, Mats Isaksson, Robert Finck, Robert Wålinder, Afrah Mamour, Christopher Rääf
In connection with the Chernobyl fallout and the subsequent deposition of radionuclides in Sweden, Swedish municipalities launched a measurement program to monitor the external radiation exposure. This program encompasses measurements of the ambient dose equivalent rate 1 m above ground at selected locations, and repeats those measurements at the same locations at 7-month intervals. Measurement data compiled from the seven locations with the highest deposition were combined with data from aerial surveys since May 1986 of ground deposition of (137)Cs, high-resolution gamma spectrometry performed at four locations in May 1986, and measurements from fixed continuous air gamma rate monitoring stations from 28 April to 15 May 1986...
November 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28737683/increased-risk-of-drug-induced-hyponatremia-during-high-temperatures
#15
Anna K Jönsson, Henrik Lövborg, Wolfgang Lohr, Bertil Ekman, Joacim Rocklöv
PURPOSE: To investigate the relationship between outdoor temperature in Sweden and the reporting of drug-induced hyponatremia to the Medical Products Agency (MPA). METHODS: All individual adverse drug reactions (ADR) reported to MPA from 1 January 2010 to 31 October 2013 of suspected drug-induced hyponatremia and random controls were identified. Reports where the ADR had been assessed as having at least a possible relation to the suspected drug were included. Information on administered drugs, onset date, causality assessment, sodium levels, and the geographical origin of the reports was extracted...
July 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28715506/analysis-of-aquaporins-from-the-euryhaline-barnacle-balanus-improvisus-reveals-differential-expression-in-response-to-changes-in-salinity
#16
Ulrika Lind, Michael Järvå, Magnus Alm Rosenblad, Piero Pingitore, Emil Karlsson, Anna-Lisa Wrange, Emelie Kamdal, Kristina Sundell, Carl André, Per R Jonsson, Jon Havenhand, Leif A Eriksson, Kristina Hedfalk, Anders Blomberg
Barnacles are sessile macro-invertebrates, found along rocky shores in coastal areas worldwide. The euryhaline bay barnacle Balanus improvisus (Darwin, 1854) (= Amphibalanus improvisus) can tolerate a wide range of salinities, but the molecular mechanisms underlying the osmoregulatory capacity of this truly brackish species are not well understood. Aquaporins are pore-forming integral membrane proteins that facilitate transport of water, small solutes and ions through cellular membranes, and that have been shown to be important for osmoregulation in many organisms...
2017: PloS One
https://www.readbyqxmd.com/read/28692793/rare-x-chromosome-abnormalities-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome
#17
Rohan Sharma, Valerie M Harris, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Anum Fayaaz, Kaustubh S Chaudhari, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, Torsten Witte, Marta Alarcón-Riquelme, Xavier Mariette, Christopher J Lessard, John B Harley, Wan-Fai Ng, Astrid Rasmussen, Kathy L Sivils, R Hal Scofield
OBJECTIVE: Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both diseases are more commonly found in women than in men, at a ratio of ~10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease, suggesting a dose effect on the X chromosome. METHODS: We examined cohorts of SS and SLE patients by constructing intensity plots of X chromosome single-nucleotide polymorphism alleles, along with determining the karyotype of selected patients...
November 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28671509/periodontitis-prevalence-and-severity-in-adults-a-cross-sectional-study-in-norwegian-circumpolar-communities
#18
Gro Eirin Holde, Nils Oscarson, Tordis A Trovik, Anders Tillberg, Birgitta Jönsson
BACKGROUND: The aim of this study is to describe the prevalence, severity, and extent of periodontitis in the adult population of circumpolar communities in Norway using data from the Tromstannen-Oral Health in Northern Norway study. METHODS: In this cross-sectional survey, data were collected from a randomized population sample (aged 20 to 79 years) in Northern Norway. Periodontal conditions were assessed for 1,911 dentate adults with a full-mouth periodontal examination...
October 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28655789/acquired-immune-resistance-follows-complete-tumor-regression-without-loss-of-target-antigens-or-ifn%C3%AE-signaling
#19
Marco Donia, Katja Harbst, Marit van Buuren, Pia Kvistborg, Mattias F Lindberg, Rikke Andersen, Manja Idorn, Shamaila Munir Ahmad, Eva Ellebæk, Anja Mueller, Paolo Fagone, Ferdinando Nicoletti, Massimo Libra, Martin Lauss, Sine Reker Hadrup, Henrik Schmidt, Mads Hald Andersen, Per Thor Straten, Jonas A Nilsson, Ton N Schumacher, Barbara Seliger, Göran Jönsson, Inge Marie Svane
Cancer immunotherapy can result in durable tumor regressions in some patients. However, patients who initially respond often experience tumor progression. Here, we report mechanistic evidence of tumoral immune escape in an exemplary clinical case: a patient with metastatic melanoma who developed disease recurrence following an initial, unequivocal radiologic complete regression after T-cell-based immunotherapy. Functional cytotoxic T-cell responses, including responses to one mutant neoantigen, were amplified effectively with therapy and generated durable immunologic memory...
September 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28654911/radial-artery-intima-media-thickness-regresses-after-secondary-prevention-interventions-in-patients-post-acute-coronary-syndrome-and-is-associated-with-cardiac-and-kidney-biomarkers
#20
Damilola D Adingupu, Helena U Westergren, Santosh Dahgam, Ann-Cathrine Jönsson-Rylander, Juuso Blomster, Per Albertsson, Elmir Omerovic, Sara Svedlund, Li-Ming Gan
BACKGROUND: Radial artery intima-media thickness (rIMT) measured by ultra-high-resolution ultrasound is associated with increased cardiovascular risk and predicts outcomes. We performed non-invasive high-resolution ultrasound of the radial artery to investigate vascular changes in subjects presenting with acute coronary syndrome (ACS) and who had undergone percutaneous coronary intervention (PCI). PURPOSE: In the present work, we aimed to follow rIMT change over time post-acute coronary syndrome as a tool to monitor potential response to intensified medical therapy...
June 16, 2017: Oncotarget
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