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Per Jonsson

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https://www.readbyqxmd.com/read/29322528/mr-and-ct-data-with-multi-observer-delineations-of-organs-in-the-pelvic-area-part-of-the-gold-atlas-project
#1
Tufve Nyholm, Stina Svensson, Sebastian Andersson, Joakim Jonsson, Maja Sohlin, Christian Gustafsson, Elisabeth Kjellén, Karin Söderström, Per Albertsson, Lennart Blomqvist, Björn Zackrisson, Lars E Olsson, Adalsteinn Gunnlaugsson
PURPOSE: We describe a public dataset with MR and CT images of patients performed in the same position with both multi observer and expert consensus delineations of relevant organs in the male pelvic region. The purpose is to provide means for training and validation of segmentation algorithms and methods to convert MR to CT like data, i.e., so called synthetic CT (sCT). ACQUISITION AND VALIDATION METHODS: T1 and T2 weighted MR images as well as CT data was collected for 19 patients at three different departments...
January 11, 2018: Medical Physics
https://www.readbyqxmd.com/read/29287033/impact-of-new-medications-and-4-generic-programs-on-overactive-bladder-treatment-among-older-adults-in-the-united-states-2000-2015
#2
Alan C Kinlaw, Michele Jonsson Funk, Mitchell M Conover, Virginia Pate, Alayne D Markland, Jennifer M Wu
BACKGROUND: Despite several new medications being Food and Drug Administration-approved for overactive bladder (OAB) and new prescription drug payment programs, there are limited population-based data regarding OAB medication use among older adults. OBJECTIVES: To examine: (1) impacts of new medications and $4 generic programs on time trends for OAB-related medication dispensing for older adults in the United States; (2) differences by age and sex; and (3) temporal changes in OAB-related medication payments...
December 28, 2017: Medical Care
https://www.readbyqxmd.com/read/29241889/comparing-methods-for-estimating-direct-costs-of-adverse-drug-events
#3
Hanna Gyllensten, Anna K Jönsson, Katja M Hakkarainen, Staffan Svensson, Staffan Hägg, Clas Rehnberg
OBJECTIVES: To estimate how direct health care costs resulting from adverse drug events (ADEs) and cost distribution are affected by methodological decisions regarding identification of ADEs, assigning relevant resource use to ADEs, and estimating costs for the assigned resources. METHODS: ADEs were identified from medical records and diagnostic codes for a random sample of 4970 Swedish adults during a 3-month study period in 2008 and were assessed for causality...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29229326/quantifying-the-effect-of-3t-magnetic-resonance-imaging-residual-system-distortions-and-patient-induced-susceptibility-distortions-on-radiation-therapy-treatment-planning-for-prostate-cancer
#4
Mary Adjeiwaah, Mikael Bylund, Josef A Lundman, Camilla Thellenberg Karlsson, Joakim H Jonsson, Tufve Nyholm
PURPOSE: To investigate the effect of magnetic resonance system- and patient-induced susceptibility distortions from a 3T scanner on dose distributions for prostate cancers. METHODS AND MATERIALS: Combined displacement fields from the residual system and patient-induced susceptibility distortions were used to distort 17 prostate patient CT images. VMAT dose plans were initially optimized on distorted CT images and the plan parameters transferred to the original patient CT images to calculate a new dose distribution...
October 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29219583/comment-on-theoretical-confirmation-of-the-low-experimental-3c-3d-f-value-ratio-in-fe-xvii
#5
Kai Wang, Per Jönsson, Jörgen Ekman, Tomas Brage, Chong Yang Chen, Charlotte Froese Fischer, Gediminas Gaigalas, Michel Godefroid
A Comment on the Letter by Mendoza and Bautista [Phys. Rev. Lett. 118, 163002 (2017)PRLTAO0031-900710.1103/PhysRevLett.118.163002].
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29199105/relicts-of-the-lost-arc-high-throughput-sequencing-of-the-eutrichomyias-rowleyi-aves-passeriformes-holotype-uncovers-an-ancient-biogeographic-link-between-the-philippines-and-fiji
#6
Knud Andreas Jønsson, Mozes P K Blom, Martin Päckert, Per G P Ericson, Martin Irestedt
Molecular studies have revealed a number of cases in which traditional assessments of evolutionary relationships have been incorrect. This has implications not only for systematics and taxonomy but also for our understanding of how diversity patterns on Earth have been formed. Here, we use high-throughput sequencing technology to obtain molecular data from the holotype specimen of the elusive Eutrichomyias rowleyi, which is endemic to the Indonesian island of Sangihe. We show that E. rowleyi unexpectedly is a member of the family Lamproliidae, which dates back some 20 Million years and only include two other species, Lamprolia victoriae from Fiji and Chaetorhynchus papuensis from New Guinea...
November 30, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29197429/the-economic-contribution-of-industry-sponsored-pharmaceutical-clinical-trials
#7
Dat T Tran, Ilke Akpinar, Richard Fedorak, Egon Jonsson, John Mackey, Lawrence Richer, Philip Jacobs
In pharmaceutical clinical trials, industrial sponsors pay for study drugs and related healthcare services. We conducted a study to determine industry's economic contribution of these trials to the Alberta healthcare system.  Methods: We used data from two trial centers for cancer and non-cancer trials at the University of Alberta. For each trial (cancer, non-cancer), we calculated the cost of drugs provided by the sponsors using the market price, the cost of clinical services, and the cost of administrative services that they paid...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29195081/corrigendum-to-klinefelter-s-syndrome-47-xxy-is-in-excess-among-men-with-sj%C3%A3-gren-s-syndrome-clin-immunol-168-2016-25-29
#8
Valerie M Harris, Rohan Sharma, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Astrid Rasmussen, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Marta E Alarcon-Riquelme, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gang Xie, Katherine A Siminovitch, Wan-Fai Ng, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, TorstenWitte, Xavier Mariette, Christopher J Lessard, John B Harley, Kathy L Sivils, R Hal Scofield
No abstract text is available yet for this article.
November 28, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29195024/tuberculosis-risk-in-ankylosing-spondylitis-other-spondyloarthritis-and-psoriatic-arthritis-in-sweden-a-population-based-cohort-study
#9
Mirjam K de Vries, Elizabeth V Arkema, Jerker Jonsson, Judith Bruchfeld, Lennart Th Jacobsson, Johan Askling
OBJECTIVES: Rheumatoid arthritis (RA) is a risk factor for tuberculosis (TB), particularly following treatment with biologicals. Since these therapies are increasingly used in ankylosing spondylitis (AS), other types of spondyloarthritis (SpA) and psoriatic arthritis (PsA), we investigated the corresponding TB risks in these patients. METHODS: We identified individuals with AS/SpA/PsA, and non-AS/SpA/PsA comparators by linking Swedish national Patient, Population, TB and Rheumatology registers, and followed them for TB occurrence...
December 1, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29193305/the-genetically-determined-production-of-the-alarmin-eosinophil-derived-neurotoxin-is-reduced-in-visceral-leishmaniasis
#10
Kristin Blom, Amir I Elshafie, Ulla-Britt Jönsson, Johan Rönnelid, Lena Douhan Håkansson, Per Venge
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil-derived neurotoxin (EDN). We hypothesized that the interactions between dendritic cells and EDN might be of importance in the disease development. Cellular content of EDN was analyzed by ELISA. The single-nucleotide polymorphisms at positions 405, 416, and 1122 in the EDN gene were analyzed by real-time PCR with TaqMan® reagents...
November 29, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29123680/hit-detection-in-serial-femtosecond-crystallography-using-x-ray-spectroscopy-of-plasma-emission
#11
H Olof Jönsson, Carl Caleman, Jakob Andreasson, Nicuşor Tîmneanu
Serial femtosecond crystallography is an emerging and promising method for determining protein structures, making use of the ultrafast and bright X-ray pulses from X-ray free-electron lasers. The upcoming X-ray laser sources will produce well above 1000 pulses per second and will pose a new challenge: how to quickly determine successful crystal hits and avoid a high-rate data deluge. Proposed here is a hit-finding scheme based on detecting photons from plasma emission after the sample has been intercepted by the X-ray laser...
November 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/29083310/-pharmaceutical-care-at-the-primary-care-clinic-in-gar%C3%A3-ab%C3%A3-r-number-and-type-of-drug-therapy-problems-identified-among-elderly-clients
#12
Anna Bryndis Blondal, Anna Birna Almarsdottir, Jon Steinar Jonsson, Sveinbjorn Gizurarson
INTRODUCTION: Elderly people are a rising population in Iceland. With higher age the likelihood of drug consumption increases and thus drug therapy problems. Pharmaceutical care has been established abroad, where the pharmacist works in collaboration with other healthcare professionals to reduce patients' drug therapy problems. The aim of this research was to study the number and types of drug therapy problems of older individuals in primary care in Garðabær, by providing pharmacist-led pharmaceutical care in collaboration with general practitioners...
November 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29059225/adaptation-to-dislodgement-risk-on-wave-swept-rocky-shores-in-the-snail-littorina-saxatilis
#13
Guénolé Le Pennec, Roger K Butlin, Per R Jonsson, Ann I Larsson, Jessica Lindborg, Erik Bergström, Anja M Westram, Kerstin Johannesson
The periwinkle Littorina saxatilis has repeatedly evolved both a small, fragile and globose "wave ecotype" confined to wave-swept shores and a large, robust and elongated "crab ecotype" found in nearby crab-rich but less-exposed shores. This phenotypic divergence is assumed to reflect, in some part, local adaptation to wave exposure, but this hypothesis has received incomplete experimental testing. Here, we report a test of the prediction that the wave ecotype has a higher capacity to resist water flow than the crab ecotype...
2017: PloS One
https://www.readbyqxmd.com/read/29049328/ca-19-9-and-ca-125-as-potential-predictors-of-disease-recurrence-in-resectable-lung-adenocarcinoma
#14
Sofi Isaksson, Per Jönsson, Nastaran Monsef, Hans Brunnström, Pär-Ola Bendahl, Mats Jönsson, Johan Staaf, Maria Planck
OBJECTIVES: Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. MATERIAL AND METHODS: Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28978527/dispatch-of-firefighters-and-police-officers-in-out-of-hospital-cardiac-arrest-a-nationwide-prospective-cohort-trial-using-propensity-score-analysis
#15
Ingela Hasselqvist-Ax, Per Nordberg, Johan Herlitz, Leif Svensson, Martin Jonsson, Jonny Lindqvist, Mattias Ringh, Andreas Claesson, Johan Björklund, Jan-Otto Andersson, Caroline Ericson, Pär Lindblad, Lars Engerström, Mårten Rosenqvist, Jacob Hollenberg
BACKGROUND: Dispatch of basic life support-trained first responders equipped with automated external defibrillators in addition to advanced life support-trained emergency medical services personnel in out-of-hospital cardiac arrest (OHCA) has, in some minor cohort studies, been associated with improved survival. The aim of this study was to evaluate the association between basic life support plus advanced life support response and survival in OHCA at a national level. METHODS AND RESULTS: This prospective cohort study was conducted from January 1, 2012, to December 31, 2014...
October 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28959963/parental-influence-on-human-germline-de-novo-mutations-in-1-548-trios-from-iceland
#16
Hákon Jónsson, Patrick Sulem, Birte Kehr, Snaedis Kristmundsdottir, Florian Zink, Eirikur Hjartarson, Marteinn T Hardarson, Kristjan E Hjorleifsson, Hannes P Eggertsson, Sigurjon Axel Gudjonsson, Lucas D Ward, Gudny A Arnadottir, Einar A Helgason, Hannes Helgason, Arnaldur Gylfason, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Thorunn Rafnar, Mike Frigge, Simon N Stacey, Olafur Th Magnusson, Unnur Thorsteinsdottir, Gisli Masson, Augustine Kong, Bjarni V Halldorsson, Agnar Helgason, Daniel F Gudbjartsson, Kari Stefansson
The characterization of mutational processes that generate sequence diversity in the human genome is of paramount importance both to medical genetics and to evolutionary studies. To understand how the age and sex of transmitting parents affect de novo mutations, here we sequence 1,548 Icelanders, their parents, and, for a subset of 225, at least one child, to 35× genome-wide coverage. We find 108,778 de novo mutations, both single nucleotide polymorphisms and indels, and determine the parent of origin of 42,961...
September 28, 2017: Nature
https://www.readbyqxmd.com/read/28881821/radial-artery-intima-media-thickness-regresses-after-secondary-prevention-interventions-in-patients-post-acute-coronary-syndrome-and-is-associated-with-cardiac-and-kidney-biomarkers
#17
Damilola D Adingupu, Helena U Westergren, Santosh Dahgam, Ann-Cathrine Jönsson-Rylander, Juuso Blomster, Per Albertsson, Elmir Omerovic, Sara Svedlund, Li-Ming Gan
BACKGROUND: Radial artery intima-media thickness (rIMT) measured by ultra-high-resolution ultrasound is associated with increased cardiovascular risk and predicts outcomes. We performed non-invasive high-resolution ultrasound of the radial artery to investigate vascular changes in subjects presenting with acute coronary syndrome (ACS) and who had undergone percutaneous coronary intervention (PCI). PURPOSE: In the present work, we aimed to follow rIMT change over time post-acute coronary syndrome as a tool to monitor potential response to intensified medical therapy...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878712/how-game-location-affects-soccer-performance-t-pattern-analysis-of-attack-actions-in-home-and-away-matches
#18
Barbara Diana, Valentino Zurloni, Massimiliano Elia, Cesare M Cavalera, Gudberg K Jonsson, M Teresa Anguera
The influence of game location on performance has been widely examined in sport contexts. Concerning soccer, game-location affects positively the secondary and tertiary level of performance; however, there are fewer evidences about its effect on game structure (primary level of performance). This study aimed to detect the effect of game location on a primary level of performance in soccer. In particular, the objective was to reveal the hidden structures underlying the attack actions, in both home and away matches played by a top club (Serie A 2012/2013-First Leg)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28860772/factors-associated-with-failure-to-achieve-remission-and-with-relapse-after-remission-in-patients-with-major-depressive-disorder-in-the-perform-study
#19
Delphine Saragoussi, Maëlys Touya, Josep Maria Haro, Bengt Jönsson, Martin Knapp, Bastien Botrel, Ioana Florea, Henrik Loft, Benoît Rive
BACKGROUND: The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28840772/a-health-economic-lifetime-treatment-pathway-model-for-low-back-pain-in-sweden
#20
Gylfi Olafsson, Emma Jonsson, Peter Fritzell, Olle Hägg, Fredrik Borgström
AIMS: To develop a health economic model to evaluate the long-term costs and outcomes over the healthcare treatment pathway for patients with low back pain (LBP). MATERIALS AND METHODS: A health economic model, consisting of a decision tree structure with a Markov microsimulation model at the end of each branch, was created. Patients were followed from first observed clinical presentation with LBP until the age of 100 years or death. The underlying data to populate the model were based on Swedish national and regional registry data on healthcare resource use and sickness insurance in patients presenting with LBP in the Swedish region Västra Götaland during 2008-2012...
September 11, 2017: Journal of Medical Economics
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