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Per Jonsson

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https://www.readbyqxmd.com/read/28195389/no-increased-risk-of-cardiovascular-events-in-older-adults-initiating-dipeptidyl-peptidase-4-inhibitors-versus-therapeutic-alternatives
#1
Mugdha Gokhale, John B Buse, Michele Jonsson Funk, Jennifer Lund, Virginia Pate, Ross J Simpson, Til Stürmer
OBJECTIVE: Randomized placebo-controlled trials have examined the cardiovascular (CV) effects of dipeptidyl peptidase-4 inhibitors (DPP-4i), but data on incidence relative to therapeutic alternatives are limited in the older US Medicare population. We compared the CV risk with DPP-4i relative to sulfonylureas (SU) and thiazolidinediones (TZD). METHODS: During 2007-2013, using Medicare beneficiaries >65 years we identified two new-user cohorts without the use of drugs being compared in the 6 months before initiation: DPP-4i versus SU and DPP-4i versus TZD...
February 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28166213/genome-wide-association-analyses-for-lung-function-and-chronic-obstructive-pulmonary-disease-identify-new-loci-and-potential-druggable-targets
#2
Louise V Wain, Nick Shrine, María Soler Artigas, A Mesut Erzurumluoglu, Boris Noyvert, Lara Bossini-Castillo, Ma'en Obeidat, Amanda P Henry, Michael A Portelli, Robert J Hall, Charlotte K Billington, Tracy L Rimington, Anthony G Fenech, Catherine John, Tineka Blake, Victoria E Jackson, Richard J Allen, Bram P Prins, Archie Campbell, David J Porteous, Marjo-Riitta Jarvelin, Matthias Wielscher, Alan L James, Jennie Hui, Nicholas J Wareham, Jing Hua Zhao, James F Wilson, Peter K Joshi, Beate Stubbe, Rajesh Rawal, Holger Schulz, Medea Imboden, Nicole M Probst-Hensch, Stefan Karrasch, Christian Gieger, Ian J Deary, Sarah E Harris, Jonathan Marten, Igor Rudan, Stefan Enroth, Ulf Gyllensten, Shona M Kerr, Ozren Polasek, Mika Kähönen, Ida Surakka, Veronique Vitart, Caroline Hayward, Terho Lehtimäki, Olli T Raitakari, David M Evans, A John Henderson, Craig E Pennell, Carol A Wang, Peter D Sly, Emily S Wan, Robert Busch, Brian D Hobbs, Augusto A Litonjua, David W Sparrow, Amund Gulsvik, Per S Bakke, James D Crapo, Terri H Beaty, Nadia N Hansel, Rasika A Mathias, Ingo Ruczinski, Kathleen C Barnes, Yohan Bossé, Philippe Joubert, Maarten van den Berge, Corry-Anke Brandsma, Peter D Paré, Don D Sin, David C Nickle, Ke Hao, Omri Gottesman, Frederick E Dewey, Shannon E Bruse, David J Carey, H Lester Kirchner, Stefan Jonsson, Gudmar Thorleifsson, Ingileif Jonsdottir, Thorarinn Gislason, Kari Stefansson, Claudia Schurmann, Girish Nadkarni, Erwin P Bottinger, Ruth J F Loos, Robin G Walters, Zhengming Chen, Iona Y Millwood, Julien Vaucher, Om P Kurmi, Liming Li, Anna L Hansell, Chris Brightling, Eleftheria Zeggini, Michael H Cho, Edwin K Silverman, Ian Sayers, Gosia Trynka, Andrew P Morris, David P Strachan, Ian P Hall, Martin D Tobin
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1...
February 6, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28150226/can-spatiotemporal-fluoride-18-f-uptake-be-used-to-assess-bone-formation-in-the-tibia-a-longitudinal-study-using-pet-ct
#3
Henrik Lundblad, Charlotte Karlsson-Thur, Gerald Q Maguire, Cathrine Jonsson, Marilyn E Noz, Michael P Zeleznik, Lars Weidenhielm
BACKGROUND: When a bone is broken for any reason, it is important for the orthopaedic surgeon to know how bone healing is progressing. There has been resurgence in the use of the fluoride ((18)F(-)) ion to evaluate various bone conditions. This has been made possible by availability of positron emission tomography (PET)/CT hybrid scanners together with cyclotrons. Absorbed on the bone surface from blood flow, (18)F(-) attaches to the osteoblasts in cancellous bone and acts as a pharmacokinetic agent, which reflects the local physiologic activity of bone...
February 1, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28146017/profile-of-low-back-pain-treatment-and-costs-associated-with-patients-referred-to-orthopaedic-specialists-in-sweden
#4
Emma Jonsson, Gylfi Olafsson, Peter Fritzell, Olle Hägg, Fredrik Borgström
STUDY DESIGN: Analysis of Swedish national and regional register data. OBJECTIVES: The aim of this study was to characterize healthcare resource utilization, productivity loss, and costs of patients with low back pain (LBP) with or without leg pain, who have been referred from primary care settings to orthopedic specialist care. SUMMARY OF BACKGROUND DATA: Register data on outpatient and inpatient care, work absence, drug prescriptions, socioeconomics, and mortality were extracted for patients visiting orthopedic specialists for LBP in the Swedish region Västra Götaland (1...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28120526/speech-production-in-3-year-old-internationally-adopted-children-with-unilateral-cleft-lip-and-palate
#5
AnnaKarin Larsson, Johnna Schölin, Hans Mark, Radi Jönsson, Christina Persson
BACKGROUND: In the last decade, a large number of children with cleft lip and palate have been adopted to Sweden. A majority of the children were born in China and they usually arrive in Sweden with an unoperated palate. There is currently a lack of knowledge regarding speech and articulation development in this group of children, who also have to deal with a late first language switch. AIMS: To study consonant proficiency in 3-year-old internationally adopted children with unilateral cleft lip and palate (UCLP) compared with peers with UCLP born in Sweden...
January 24, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28076375/sensiblesleep-a-bayesian-model-for-learning-sleep-patterns-from-smartphone-events
#6
Andrea Cuttone, Per Bækgaard, Vedran Sekara, Håkan Jonsson, Jakob Eg Larsen, Sune Lehmann
We propose a Bayesian model for extracting sleep patterns from smartphone events. Our method is able to identify individuals' daily sleep periods and their evolution over time, and provides an estimation of the probability of sleep and wake transitions. The model is fitted to more than 400 participants from two different datasets, and we verify the results against ground truth from dedicated armband sleep trackers. We show that the model is able to produce reliable sleep estimates with an accuracy of 0.89, both at the individual and at the collective level...
2017: PloS One
https://www.readbyqxmd.com/read/28057005/intragenerational-social-mobility-and-functional-somatic-symptoms-in-a-northern-swedish-context-analyses-of-diagonal-reference-models
#7
Frida Jonsson, Miguel San Sebastian, Anne Hammarström, Per E Gustafsson
BACKGROUND: Research indicate that social class mobility could be potentially important for health, but whether this is due to the movement itself or a result of people having been integrated in different class contexts is, to date, difficult to infer. In addition, although several theories suggest that transitions between classes in the social hierarchy can be stressful experiences, few studies have empirically examined whether such movements may have health effects, over and above the implications of "being" in these classes...
January 3, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28052240/trim28-controls-a-gene-regulatory-network-based-on-endogenous-retroviruses-in-human-neural-progenitor-cells
#8
Per Ludvik Brattås, Marie E Jönsson, Liana Fasching, Jenny Nelander Wahlestedt, Mansoureh Shahsavani, Ronny Falk, Anna Falk, Patric Jern, Malin Parmar, Johan Jakobsson
Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28025871/editorial-per-brandtzaeg-in-memoriam
#9
EDITORIAL
R Jonsson
No abstract text is available yet for this article.
December 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27986093/the-societal-costs-of-dementia-in-sweden-2012-relevance-and-methodological-challenges-in-valuing-informal-care
#10
Anders Wimo, Linus Jönsson, Laura Fratiglioni, Per Olof Sandman, Anders Gustavsson, Anders Sköldunger, Lennarth Johansson
BACKGROUND: In this study, we sought to estimate the societal cost of illness in dementia in Sweden in 2012 using different costing approaches to highlight methodological issues. METHODS: We conducted a prevalence-based cost-of-illness study with a societal perspective. RESULTS: The societal costs of dementia in Sweden in 2012 were SEK 62.9 billion (approximately €7.2 billion, approximately US$9.0 billion) or SEK 398,000 per person with dementia (approximately €45,000, approximately US$57,000)...
November 18, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27898309/diverging-temporal-trends-of-human-exposure-to-bisphenols-and-plastizisers-such-as-phthalates-caused-by-substitution-of-legacy-edcs
#11
Irina Gyllenhammar, Anders Glynn, Bo A G Jönsson, Christian H Lindh, Per Ola Darnerud, Kettil Svensson, Sanna Lignell
Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides...
November 26, 2016: Environmental Research
https://www.readbyqxmd.com/read/27894838/direct-and-indirect-costs-for-adverse-drug-events-identified-in-medical-records-across-care-levels-and-their-distribution-among-payers
#12
Jennie Natanaelsson, Katja M Hakkarainen, Staffan Hägg, Karolina Andersson Sundell, Max Petzold, Clas Rehnberg, Anna K Jönsson, Hanna Gyllensten
BACKGROUND: Adverse drug events (ADEs) cause considerable costs in hospitals. However, little is known about costs caused by ADEs outside hospitals, effects on productivity, and how the costs are distributed among payers. OBJECTIVE: To describe the direct and indirect costs caused by ADEs, and their distribution among payers. Furthermore, to describe the distribution of patient out-of-pocket costs and lost productivity caused by ADEs according to socio-economic characteristics...
November 19, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27894337/intestinal-dysbiosis-is-common-in-systemic-sclerosis-and-associated-with-gastrointestinal-and-extraintestinal-features-of-disease
#13
Kristofer Andréasson, Zaid Alrawi, Anita Persson, Göran Jönsson, Jan Marsal
BACKGROUND: Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate the prevalence of intestinal dysbiosis in SSc and to characterise patients suffering from this potentially immunomodulatory deviation. METHODS: This study consisted of 98 consecutive patients subject to in-hospital care. Stool samples were analysed for intestinal microbiota composition using a validated genome-based microbiota test (GA-map™ Dysbiosis Test, Genetic Analysis, Oslo, Norway)...
November 29, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27893055/assessment-of-use-vs-discontinuation-of-oral-anticoagulation-after-pulmonary-vein-isolation-in-patients-with-atrial-fibrillation
#14
Sara Själander, Fredrik Holmqvist, J Gustav Smith, Pyotr G Platonov, Milos Kesek, Peter J Svensson, Carina Blomström-Lundqvist, Fariborz Tabrizi, Jari Tapanainen, Dritan Poci, Anders Jönsson, Anders Själander
Importance: Pulmonary vein isolation (PVI) is a recommended treatment for patients with atrial fibrillation, but it is unclear whether it results in a lower risk of stroke. Objectives: To investigate the proportion of patients discontinuing anticoagulation treatment after PVI in association with the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65-74 years, sex category [female]) score, identify factors predicting stroke after PVI, and explore the risk of cardiovascular events after PVI in patients with and without guideline-recommended anticoagulation treatment...
February 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27846319/genetic-correlation-between-body-fat-percentage-and-cardiorespiratory-fitness-suggests-common-genetic-etiology
#15
Theresia M Schnurr, Anette P Gjesing, Camilla H Sandholt, Anna Jonsson, Yuvaraj Mahendran, Christian T Have, Claus T Ekstrøm, Anne-Louise Bjerregaard, Soren Brage, Daniel R Witte, Marit E Jørgensen, Mette Aadahl, Betina H Thuesen, Allan Linneberg, Hans Eiberg, Oluf Pedersen, Niels Grarup, Tuomas O Kilpeläinen, Torben Hansen
OBJECTIVES: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF...
2016: PloS One
https://www.readbyqxmd.com/read/27815868/a-prospective-population-pharmacokinetic-study-on-morphine-metabolism-in-cancer-patients
#16
Astrid W Oosten, João A Abrantes, Siv Jönsson, Maja Matic, Ron H N van Schaik, Peter de Bruijn, Carin C D van der Rijt, Ron H J Mathijssen
BACKGROUND: Oral and subcutaneous morphine is widely used for the treatment of cancer-related pain; however, solid pharmacokinetic data on this practice are lacking. Furthermore, it is largely unknown which factors contribute to the variability in clearances of morphine and its metabolites and whether morphine clearance is related to treatment outcome. METHODS: Blood samples from 49 cancer patients treated with oral and/or subcutaneous morphine were prospectively collected and were used to develop a population pharmacokinetic model for morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G)...
November 5, 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27813488/-epidemiology-of-spinal-cord-injury-in-iceland-from-1975-to-2014
#17
Eyrún Arna Kristinsdottir, Sigrun Knutsdottir, Kristinn Sigvaldason, Halldor Jonsson, Pall E Ingvarsson
INTRODUCTION: Traumatic spinal cord injury (TSCI) is serious and often has long-term consequences. Since no cure has been found the emphasis has been on preventive measures. The incidence of TSCI varies between countries and the epidemiology has been changing. The aim of this study was to gather epidemiological data on patients with TSCI in Iceland and search for risk factors. MATERIAL AND METHODS: Hospital records of everyone diagnosed with TSCI in 1975-2014 admitted to Landspitali University Hospital were reviewed and information gathered on incidence, age, gender and causes of injury...
November 2016: Læknablađiđ
https://www.readbyqxmd.com/read/27807699/position-paper-on-screening-for-breast-cancer-by-the-european-society-of-breast-imaging-eusobi-and-30-national-breast-radiology-bodies-from-austria-belgium-bosnia-and-herzegovina-bulgaria-croatia-czech-republic-denmark-estonia-finland-france-germany-greece
#18
Francesco Sardanelli, Hildegunn S Aase, Marina Álvarez, Edward Azavedo, Henk J Baarslag, Corinne Balleyguier, Pascal A Baltzer, Vanesa Beslagic, Ulrich Bick, Dragana Bogdanovic-Stojanovic, Ruta Briediene, Boris Brkljacic, Julia Camps Herrero, Catherine Colin, Eleanor Cornford, Jan Danes, Gérard de Geer, Gul Esen, Andrew Evans, Michael H Fuchsjaeger, Fiona J Gilbert, Oswald Graf, Gormlaith Hargaden, Thomas H Helbich, Sylvia H Heywang-Köbrunner, Valentin Ivanov, Ásbjörn Jónsson, Christiane K Kuhl, Eugenia C Lisencu, Elzbieta Luczynska, Ritse M Mann, Jose C Marques, Laura Martincich, Margarete Mortier, Markus Müller-Schimpfle, Katalin Ormandi, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Katja Pinker, Tarja Rissanen, Natalia Rotaru, Gianni Saguatti, Tamar Sella, Jana Slobodníková, Maret Talk, Patrice Taourel, Rubina M Trimboli, Ilse Vejborg, Athina Vourtsis, Gabor Forrai
: EUSOBI and 30 national breast radiology bodies support mammography for population-based screening, demonstrated to reduce breast cancer (BC) mortality and treatment impact. According to the International Agency for Research on Cancer, the reduction in mortality is 40 % for women aged 50-69 years taking up the invitation while the probability of false-positive needle biopsy is <1 % per round and overdiagnosis is only 1-10 % for a 20-year screening. Mortality reduction was also observed for the age groups 40-49 years and 70-74 years, although with "limited evidence"...
November 2, 2016: European Radiology
https://www.readbyqxmd.com/read/27806528/adolescent-centered-pain-management-in-school-when-adolescents-have-chronic-pain-a-qualitative-study
#19
Stefan Nilsson, Per-Åke Rosvall, Annikki Jonsson
Chronic pain is common among Swedish adolescents, and stress is an independent factor in the onset and persistence of chronic pain. When Swedish school nurses conduct their health dialogs they have a unique opportunity to find adolescents with chronic pain. The aim of this study was to explore school nurses' and adolescents' experiences of factors that influence adolescent-centered pain management in school health care, when adolescents have chronic pain. The study context is schools in Sweden where primary health care is available through school nurses...
August 4, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27633075/vitamin-d-in-relation-to-bone-health-and-muscle-function-in%C3%A2-young%C3%A2-female-soccer-players
#20
André Brännström, Ji-Guo Yu, Per Jonsson, Torbjörn Åkerfeldt, Mats Stridsberg, Michael Svensson
The present work investigated serum vitamin D (25(OH)D) status in relation to bone and muscle qualities and functions in 19 female soccer players (13-16 years) resident at northern latitude with very low sun exposure (∼32-36 h/month) during winter season (late January to early March). Serum 25(OH)D, parathyroid hormone and bone turnover markers osteocalcin (OC) and beta carboxy-terminal collagen cross-links (β-Ctx), as well as body composition and muscle performance were examined. Hormones were tested using routine laboratory methods...
March 2017: European Journal of Sport Science
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