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Per Jonsson

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https://www.readbyqxmd.com/read/27898309/diverging-temporal-trends-of-human-exposure-to-bisphenols-and-plastizisers-such-as-phthalates-caused-by-substitution-of-legacy-edcs
#1
Irina Gyllenhammar, Anders Glynn, Bo A G Jönsson, Christian H Lindh, Per Ola Darnerud, Kettil Svensson, Sanna Lignell
Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides...
November 26, 2016: Environmental Research
https://www.readbyqxmd.com/read/27894838/direct-and-indirect-costs-for-adverse-drug-events-identified-in-medical-records-across-care-levels-and-their-distribution-among-payers
#2
Jennie Natanaelsson, Katja M Hakkarainen, Staffan Hägg, Karolina Andersson Sundell, Max Petzold, Clas Rehnberg, Anna K Jönsson, Hanna Gyllensten
BACKGROUND: Adverse drug events (ADEs) cause considerable costs in hospitals. However, little is known about costs caused by ADEs outside hospitals, effects on productivity, and how the costs are distributed among payers. OBJECTIVE: To describe the direct and indirect costs caused by ADEs, and their distribution among payers. Furthermore, to describe the distribution of patient out-of-pocket costs and lost productivity caused by ADEs according to socio-economic characteristics...
November 19, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27894337/intestinal-dysbiosis-is-common-in-systemic-sclerosis-and-associated-with-gastrointestinal-and-extraintestinal-features-of-disease
#3
Kristofer Andréasson, Zaid Alrawi, Anita Persson, Göran Jönsson, Jan Marsal
BACKGROUND: Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate the prevalence of intestinal dysbiosis in SSc and to characterise patients suffering from this potentially immunomodulatory deviation. METHODS: This study consisted of 98 consecutive patients subject to in-hospital care. Stool samples were analysed for intestinal microbiota composition using a validated genome-based microbiota test (GA-map™ Dysbiosis Test, Genetic Analysis, Oslo, Norway)...
November 29, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27893055/assessment-of-use-vs-discontinuation-of-oral-anticoagulation-after-pulmonary-vein-isolation-in-patients-with-atrial-fibrillation
#4
Sara Själander, Fredrik Holmqvist, J Gustav Smith, Pyotr G Platonov, Milos Kesek, Peter J Svensson, Carina Blomström-Lundqvist, Fariborz Tabrizi, Jari Tapanainen, Dritan Poci, Anders Jönsson, Anders Själander
Importance: Pulmonary vein isolation (PVI) is a recommended treatment for patients with atrial fibrillation, but it is unclear whether it results in a lower risk of stroke. Objectives: To investigate the proportion of patients discontinuing anticoagulation treatment after PVI in association with the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65-74 years, sex category [female]) score, identify factors predicting stroke after PVI, and explore the risk of cardiovascular events after PVI in patients with and without guideline-recommended anticoagulation treatment...
November 23, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27846319/genetic-correlation-between-body-fat-percentage-and-cardiorespiratory-fitness-suggests-common-genetic-etiology
#5
Theresia M Schnurr, Anette P Gjesing, Camilla H Sandholt, Anna Jonsson, Yuvaraj Mahendran, Christian T Have, Claus T Ekstrøm, Anne-Louise Bjerregaard, Soren Brage, Daniel R Witte, Marit E Jørgensen, Mette Aadahl, Betina H Thuesen, Allan Linneberg, Hans Eiberg, Oluf Pedersen, Niels Grarup, Tuomas O Kilpeläinen, Torben Hansen
OBJECTIVES: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF...
2016: PloS One
https://www.readbyqxmd.com/read/27815868/a-prospective-population-pharmacokinetic-study-on-morphine-metabolism-in-cancer-patients
#6
Astrid W Oosten, João A Abrantes, Siv Jönsson, Maja Matic, Ron H N van Schaik, Peter de Bruijn, Carin C D van der Rijt, Ron H J Mathijssen
BACKGROUND: Oral and subcutaneous morphine is widely used for the treatment of cancer-related pain; however, solid pharmacokinetic data on this practice are lacking. Furthermore, it is largely unknown which factors contribute to the variability in clearances of morphine and its metabolites and whether morphine clearance is related to treatment outcome. METHODS: Blood samples from 49 cancer patients treated with oral and/or subcutaneous morphine were prospectively collected and were used to develop a population pharmacokinetic model for morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G)...
November 5, 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27813488/-epidemiology-of-spinal-cord-injury-in-iceland-from-1975-to-2014
#7
Eyrún Arna Kristinsdottir, Sigrun Knutsdottir, Kristinn Sigvaldason, Halldor Jonsson, Pall E Ingvarsson
INTRODUCTION: Traumatic spinal cord injury (TSCI) is serious and often has long-term consequences. Since no cure has been found the emphasis has been on preventive measures. The incidence of TSCI varies between countries and the epidemiology has been changing. The aim of this study was to gather epidemiological data on patients with TSCI in Iceland and search for risk factors. MATERIAL AND METHODS: Hospital records of everyone diagnosed with TSCI in 1975-2014 admitted to Landspitali University Hospital were reviewed and information gathered on incidence, age, gender and causes of injury...
November 2016: Læknablađiđ
https://www.readbyqxmd.com/read/27807699/position-paper-on-screening-for-breast-cancer-by-the-european-society-of-breast-imaging-eusobi-and-30-national-breast-radiology-bodies-from-austria-belgium-bosnia-and-herzegovina-bulgaria-croatia-czech-republic-denmark-estonia-finland-france-germany-greece
#8
Francesco Sardanelli, Hildegunn S Aase, Marina Álvarez, Edward Azavedo, Henk J Baarslag, Corinne Balleyguier, Pascal A Baltzer, Vanesa Beslagic, Ulrich Bick, Dragana Bogdanovic-Stojanovic, Ruta Briediene, Boris Brkljacic, Julia Camps Herrero, Catherine Colin, Eleanor Cornford, Jan Danes, Gérard de Geer, Gul Esen, Andrew Evans, Michael H Fuchsjaeger, Fiona J Gilbert, Oswald Graf, Gormlaith Hargaden, Thomas H Helbich, Sylvia H Heywang-Köbrunner, Valentin Ivanov, Ásbjörn Jónsson, Christiane K Kuhl, Eugenia C Lisencu, Elzbieta Luczynska, Ritse M Mann, Jose C Marques, Laura Martincich, Margarete Mortier, Markus Müller-Schimpfle, Katalin Ormandi, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Katja Pinker, Tarja Rissanen, Natalia Rotaru, Gianni Saguatti, Tamar Sella, Jana Slobodníková, Maret Talk, Patrice Taourel, Rubina M Trimboli, Ilse Vejborg, Athina Vourtsis, Gabor Forrai
: EUSOBI and 30 national breast radiology bodies support mammography for population-based screening, demonstrated to reduce breast cancer (BC) mortality and treatment impact. According to the International Agency for Research on Cancer, the reduction in mortality is 40 % for women aged 50-69 years taking up the invitation while the probability of false-positive needle biopsy is <1 % per round and overdiagnosis is only 1-10 % for a 20-year screening. Mortality reduction was also observed for the age groups 40-49 years and 70-74 years, although with "limited evidence"...
November 2, 2016: European Radiology
https://www.readbyqxmd.com/read/27806528/adolescent-centered-pain-management-in-school-when-adolescents-have-chronic-pain-a-qualitative-study
#9
Stefan Nilsson, Per-Åke Rosvall, Annikki Jonsson
Chronic pain is common among Swedish adolescents, and stress is an independent factor in the onset and persistence of chronic pain. When Swedish school nurses conduct their health dialogs they have a unique opportunity to find adolescents with chronic pain. The aim of this study was to explore school nurses' and adolescents' experiences of factors that influence adolescent-centered pain management in school health care, when adolescents have chronic pain. The study context is schools in Sweden where primary health care is available through school nurses...
August 4, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27633075/vitamin-d-in-relation-to-bone-health-and-muscle-function-in-young-female-soccer-players
#10
André Brännström, Ji-Guo Yu, Per Jonsson, Torbjörn Åkerfeldt, Mats Stridsberg, Michael Svensson
The present work investigated serum vitamin D (25(OH)D) status in relation to bone and muscle qualities and functions in 19 female soccer players (13-16 years) resident at northern latitude with very low sun exposure (∼32-36 h/month) during winter season (late January to early March). Serum 25(OH)D, parathyroid hormone and bone turnover markers osteocalcin (OC) and beta carboxy-terminal collagen cross-links (β-Ctx), as well as body composition and muscle performance were examined. Hormones were tested using routine laboratory methods...
September 15, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27589247/the-cost-and-burden-of-cancer-in-the-european-union-1995-2014
#11
Bengt Jönsson, Thomas Hofmarcher, Peter Lindgren, Nils Wilking
BACKGROUND: There is an intense debate about the cost of cancer and the value of new treatments. However, there is limited data on the cost of cancer in the European Union (EU) and how costs relate to the burden of disease. This paper presents new estimates on the development of the cost of cancer in the EU 1995-2014, with a focus on the major cost components: total health expenditure, cancer drugs, and production loss due to premature mortality. METHODS: Data on overall health expenditure were combined with national disease estimates to derive cancer-specific health expenditure...
October 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27583652/the-worldwide-costs-of-dementia-2015-and-comparisons-with-2010
#12
Anders Wimo, Maëlenn Guerchet, Gemma-Claire Ali, Yu-Tzu Wu, A Matthew Prina, Bengt Winblad, Linus Jönsson, Zhaorui Liu, Martin Prince
INTRODUCTION: In 2010, Alzheimer's Disease International presented estimates of the global cost of illness (COI) of dementia. Since then, new studies have been conducted, and the number of people with dementia has increased. Here, we present an update of the global cost estimates. METHODS: This is a societal, prevalence-based global COI study. RESULTS: The worldwide costs of dementia were estimated at United States (US) $818 billion in 2015, an increase of 35% since 2010; 86% of the costs occur in high-income countries...
August 29, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27581886/correction-to-the-evolution-of-mimicry-of-friarbirds-by-orioles-aves-passeriformes-in-australo-pacific-archipelagos
#13
Knud Andreas Jønsson, Kaspar Delhey, George Sangster, Per G P Ericson, Martin Irestedt
No abstract text is available yet for this article.
August 31, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27563465/a-few-observations-on-health-service-for-immigrants-at-a-primary-health-care-centre
#14
Thorhildur Halldorsdottir, Halldor Jonsson, Kristjan G Gudmundsson
Objective. Icelandic society is rapidly changing, from being an ethnically homogeneous population towards a multicultural immigrant society. In the hope of optimizing the service for immigrants at the health care centre, we decided to evaluate health care utilization by immigrants. Methods. As a case control study we invited all immigrants that attended the health care centre during a two-week period to participate. Paired controls of Icelanders were invited for comparison. Results. There were 57 immigrants, 48 females and 9 males, from 27 countries...
2016: International Journal of Family Medicine
https://www.readbyqxmd.com/read/27537217/psychological-treatment-of-depression-in-people-aged-65-years-and-over-a-systematic-review-of-efficacy-safety-and-cost-effectiveness
#15
Ulf Jonsson, Göran Bertilsson, Per Allard, Harald Gyllensvärd, Anne Söderlund, Anne Tham, Gerhard Andersson
OBJECTIVES: Depression in elderly people is a major public health concern. As response to antidepressants is often unsatisfactory in this age group, there is a need for evidence-based non-pharmacological treatment options. Our objectives were twofold: firstly, to synthesize published trials evaluating efficacy, safety and cost-effectiveness of psychological treatment of depression in the elderly and secondly, to assess the quality of evidence. METHOD: The electronic databases PubMed, EMBASE, Cochrane Library, CINAL, Scopus, and PsycINFO were searched up to 23 May 2016 for randomized controlled trials (RCTs) of psychological treatment for depressive disorders or depressive symptoms in people aged 65 years and over...
2016: PloS One
https://www.readbyqxmd.com/read/27525473/direct-observation-of-dna-knots-using-a-solid-state-nanopore
#16
Calin Plesa, Daniel Verschueren, Sergii Pud, Jaco van der Torre, Justus W Ruitenberg, Menno J Witteveen, Magnus P Jonsson, Alexander Y Grosberg, Yitzhak Rabin, Cees Dekker
Long DNA molecules can self-entangle into knots. Experimental techniques for observing such DNA knots (primarily gel electrophoresis) are limited to bulk methods and circular molecules below 10 kilobase pairs in length. Here, we show that solid-state nanopores can be used to directly observe individual knots in both linear and circular single DNA molecules of arbitrary length. The DNA knots are observed as short spikes in the nanopore current traces of the traversing DNA molecules and their detection is dependent on a sufficiently high measurement resolution, which can be achieved using high-concentration LiCl buffers...
August 15, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27463968/instantaneous-flow-structures-and-opportunities-for-larval-settlement-barnacle-larvae-swim-to-settle
#17
Ann I Larsson, Lena M Granhag, Per R Jonsson
Water flow affects settlement of marine larvae on several scales. At the smallest scale local flow regime may control the probability of adhesion to the substrate. Our aim was to mechanistically understand the transition from suspended to attached larvae in turbulent flow. Recently it was proposed that opportunities for larval settlement in turbulent boundary layers depend on time windows with suitable instantaneous flow properties. In flume flow we characterized the proportion of suitable time windows in a series of flow velocities with focus on the near-bed flow...
2016: PloS One
https://www.readbyqxmd.com/read/27393179/expanding-the-first-link-in-the-chain-of-survival-experiences-from-dispatcher-referral-of-callers-to-aed-locations
#18
David Fredman, Leif Svensson, Yifang Ban, Martin Jonsson, Jacob Hollenberg, Per Nordberg, Mattias Ringh, Mårten Rosenqvist, Margareta Lundén, Andreas Claesson
INTRODUCTION: Early use of automated external defibrillators (AED) increases survival in cases of out-of-hospital cardiac arrest (OHCA). Dispatchers play important roles in identifying OHCA, dispatching ambulances and providing callers with telephone-assisted cardiopulmonary resuscitation. Guidelines recommend that AED registries be linked to dispatch centres as tools to refer callers to nearby AED. AIM: The aim of this study was to investigate to what extent dispatchers, when provided with a tool to display AED locations and accessibility, referred callers to nearby AED...
October 2016: Resuscitation
https://www.readbyqxmd.com/read/27389296/efficacy-and-tolerability-of-antidepressants-in-people-aged-65-years-or-older-with-major-depressive-disorder-a-systematic-review-and-a-meta-analysis
#19
Anne Tham, Ulf Jonsson, Gerhard Andersson, Anne Söderlund, Per Allard, Göran Bertilsson
BACKGROUND: There has been a steady increase in the prescription of antidepressants for the elderly. This study comprises a systematic review of randomized, placebo-controlled trials of antidepressants for treatment of depressive disorder in people aged 65 years or more. METHODS: PubMed, EMBASE, Cochrane Library, CINAL, and PsycINFO were searched until May 2016. Where appropriate, the results were synthesized in meta-analyses. RESULTS: Twelve trials met the inclusion criteria...
November 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27335418/the-evolution-of-mimicry-of-friarbirds-by-orioles-aves-passeriformes-in-australo-pacific-archipelagos
#20
Knud Andreas Jønsson, Kaspar Delhey, George Sangster, Per G P Ericson, Martin Irestedt
Observations by Alfred Wallace and Jared Diamond of plumage similarities between co-occurring orioles (Oriolus) and friarbirds (Philemon) in the Malay archipelago led them to conclude that the former represent visual mimics of the latter. Here, we use molecular phylogenies and plumage reflectance measurements to test several key predictions of the mimicry hypothesis. We show that friarbirds originated before brown orioles, that the two groups did not co-speciate, although there is one plausible instance of co-speciation among species on the neighbouring Moluccan islands of Buru and Seram...
June 29, 2016: Proceedings. Biological Sciences
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