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Nicola Maffulli

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https://www.readbyqxmd.com/read/28602482/a-new-anterior-inferior-coronal-patellar-plica
#1
Francesco Sadile, Alessio Bernasconi, Nicola Maffulli
PURPOSE: To date, four synovial plicae are classically described in the knee. We report a previously undescribed new inferior patellar plica, named "bib-like plica" (BLP, referring to its morphology) related to specific symptoms of atypical recurrent anterior knee pain in the presence of a locked or pseudo-locked knee. We describe this anatomical structure, and assess its clinical relevance in daily practice in terms of clinical pattern and long-term follow-up outcome after arthroscopic excision...
June 8, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28596062/inflammation-in-tendinopathy
#2
REVIEW
Alessio D'Addona, Nicola Maffulli, Silvestro Formisano, Donato Rosa
Pain and functional limitation are frequent in symptomatic tendinopathy. The essential lesion of tendinopathy is a failed healing response. Understanding the cellular and molecular mechanisms involved in a failed healing response during the early stages of pathogenesis of tendinopathy would help to develop new and effective treatments. The role of inflammation in the development of tendon pathologies has been revived during the last few years, in particular during the first phases of tendinopathies, when "early tendinopathy" may not be clinically evident...
June 6, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28549817/static-tensioning-promotes-hamstring-tendons-force-relaxation-more-reliably-than-cycling-tensioning
#3
Sérgio Rocha Piedade, Inácio Maria Dal Fabbro, Martha Maria Mischan, Cezar Piedade, Nicola Maffulli
BACKGROUND: Graft elongation might be a major reason for increased anterior laxity after anterior cruciate ligament (ACL) reconstruction. This study analyzed the force relaxation values and their stabilization when single strands of the gracilis and semitendinosus tendons underwent cyclic and static tensioning at 2.5% strain level, and compared the efficiency of static and cyclic tensioning in promoting force relaxation. METHODS: Eighteen gracilis tendons and 18 semitendinosus tendons from nine male cadavers (mean age: 22...
May 23, 2017: Knee
https://www.readbyqxmd.com/read/28548630/tenogenic-differentiation-of-human-embryonic-stem-cells
#4
Tina P Dale, Shazia Mazher, William R Webb, Jing Zhou, Nicola Maffulli, G-Q Chen, Alicia J El Haj, Nicholas R Forsyth
Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem cells (hESC) could be induced to differentiate into tendon-like cells by the addition of exogenous bone morphogenetic protein (BMP)12 (growth differentiation factor(GDF)7) and BMP13 (GDF6). hESC (SHEF-1) were maintained with or without BMP12/13 supplementation, or supplemented with BMP12/13 and the SMAD signalling cascade blocking agent, dorsomorphin...
May 26, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28528351/the-influence-of-critical-shoulder-angle-on-secondary-rotator-cuff-insufficiency-following-shoulder-arthroplasty
#5
Simone Cerciello, Andrew Paul Monk, Enrico Visonà, Stefano Carbone, Thomas Bradley Edwards, Nicola Maffulli, Gilles Walch
INTRODUCTION: Secondary cuff failure after shoulder replacement is disabling and often requires additional surgery. Increased critical shoulder angle (CSA) has been found in patients with cuff tear compared to normal subjects. The interobserver reliability of the CSA and the relationship between CSA and symptomatic secondary cuff failure after shoulder replacement were investigated. MATERIALS AND METHODS: Nineteen patients with symptomatic cuff failure after anatomic shoulder replacement (mean FU 45 months) were compared to a control group of 29 patients showing no signs of symptomatic cuff failure (mean FU 105...
May 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28525564/radiofrequency-energy-in-the-arthroscopic-treatment-of-knee-chondral-lesions-a-systematic-review
#6
Rocco Papalia, Lorenzo Diaz Balzani, Guglielmo Torre, Michele Paciotti, Nicola Maffulli, Vincenzo Denaro
No abstract text is available yet for this article.
May 19, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28499877/novel-superparamagnetic-microdevices-based-on-magnetized-plga-pla-microparticles-obtained-by-supercritical-fluid-emulsion-and-coating-by-carboxybetaine-functionalized-chitosan-allowing-the-tuneable-release-of-therapeutics
#7
Vincenzo Cricchio, Mark Best, Ernesto Reverchon, Nicola Maffulli, Gary Phillips, Matteo Santin, Giovanna Della Porta
When superparamagnetic nanoparticles (MAG) are loaded within microcarriers of thermosensitive and injectable biopolymers, "smart" microdevices are obtained: they respond to an external magnetic field through the release of any co-encapsulated molecules with a remote on-off control. Creating reliable and effective fabrication technologies for the production of these smart nano/microdevices remains a challenge. In this work, supercritical emulsion extraction technology is proposed for the fabrication of microcapsules with a core of poly-lactic-co-glycolic acid (PLGA) or polylactic acid (PLA) covered by carboxybetaine-functionalized chitosan (f-chi) and loaded with MAG (mean size of 6...
May 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28448428/therapeutic-ultrasound-in-navicular-stress-injuries-in-elite-track-and-field-athletes
#8
Nikolaos Malliaropoulos, Dimosthenis Alaseirlis, George Konstantinidis, Agapi Papalada, Ioannis Tsifountoudis, Kosmas Petras, Nicola Maffulli
OBJECTIVE: To ascertain whether therapeutic ultrasound (TUS) can be used to assess the progression of conservative management in navicular stress injuries. DESIGN: This is a prospective, clinical case series. Level of evidence IV. SETTING: All participants were examined and followed up in a private Sports Injury Clinic. PARTICIPANTS: Ten elite track and field athletes with severe dorsal midfoot pain over the navicular bone participated in this study...
May 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28401805/an-engineered-multiphase-3d-microenvironment-to-ensure-the-controlled-delivery-of-cyclic-strain-and-hgdf-5-for-the-tenogenic-commitment-of-hbmscs
#9
Marco Govoni, Anna Berardi, Claudio Muscari, Roberta Campardelli, Francesca Bonafè, Carlo Guarnieri, Ernesto Reverchon, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
At present, injuries or rupture of tendons are treated by surgical repair or conservative approaches with unpredictable clinical outcome. Alternative strategies to repair tendon defects without the undesirable side effects associated with the current options are needed. With this in mind, a tissue engineering approach has gained considerable attention as a promising strategy. Here, we investigated a synthetic 3D microenvironment able to interact with stem cells and inducing, via coupled biochemical and physical signals, their early commitment towards the tenogenic lineage...
April 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28369181/apoptosis-and-rotator-cuff-tears-scientific-evidence-from-basic-science-to-clinical-findings
#10
Leonardo Osti, Matteo Buda, Angelo Del Buono, Raffaella Osti, Leo Massari, Nicola Maffulli
Introduction: Excessive apoptosis has been hypothesized as possible cause of tendinopathy and tear in the tendons of the rotator cuff (RC). Different mechanisms and molecules play a key role in cell regulation. Biological interventions can affect the process of apoptosis to control the tendinopathy process, and may be useful to design new treatments. Source of data: We identified basic science, in vitro and in vivo preclinical and clinical studies listed in the Pubmed Google Scholar, CINAHL, Cochrane Central and Embase Biomedical databases in English, Spanish, Italian and French concerning the effects of apoptosis on RC tendons...
June 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334196/the-effectiveness-of-prolotherapy-in-treating-knee-osteoarthritis-in-adults-a-systematic-review
#11
Fadi Hassan, Suad Trebinjac, William D Murrell, Nicola Maffulli
Introduction: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise. Sources of data: Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016...
June 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334148/surgical-versus-conservative-management-of-type-iii-acromioclavicular-dislocation-a-systematic-review
#12
Umile Giuseppe Longo, Mauro Ciuffreda, Giacomo Rizzello, Nicholas Mannering, Nicola Maffulli, Vincenzo Denaro
Introduction: The management of Type III acromioclavicular (AC) dislocations is still controversial. We wished to compare the rate of recurrence and outcome scores of operative versus non-operative treatment of patients with Type III AC dislocations. Source of data: A systematic review of the literature was performed by applying the PRISMA guidelines according to the PRISMA checklist and algorithm. A search in Medline, PubMed, Cochrane and CINAHL was performed using combinations of the following keywords: 'dislocation', 'Rockwood', 'type three', 'treatment', 'acromioclavicular' and 'joint'...
June 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28125768/a-versatile-and-highly-selective-colorimetric-sensor-for-the-detection-of-amines
#13
Yvonne J Diaz, Zachariah A Page, Abigail S Knight, Nicolas J Treat, James R Hemmer, Craig J Hawker, Javier Read de Alaniz
The utility of Meldrum's activated furan (MAF) for the colorimetric detection of sub ppm levels of amines in solution, on solid supports, and as vapors is reported. MAF is synthesized in one step from inexpensive and commercially available starting materials and exhibits high selectivity for primary and secondary amines in the presence of competing nucleophiles. The reaction between activated furans and amines results in a distinct color change, discernable by the naked eye. UV/Vis absorption spectroscopy was utilized to monitor reactions in solution and determine detection limits...
March 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28066733/viscosupplementation-with-intra-articular-hyaluronic-acid-for-hip-disorders-a-systematic-review-and-meta-analysis
#14
Eleonora Piccirilli, Francesco Oliva, Mihaela Aconstantinesei Murè, Asmaa Mahmoud, Calogero Foti, Umberto Tarantino, Nicola Maffulli
BACKGROUND: Hip joint diseases are common in adult population and their prevalence increases with age. Osteoarthritis, rheumatoid arthritis and femoroacetabular impingement are the most common chronic diseases in the hip joint. Viscosupplementation with exogenous hyaluronic acid (HA) is one of the most widely used conservative treatment aiming to improve synovial fluid properties and to decrease pain. There is no global consensus on the type of HA, method of injection and frequency, or on its efficacy in hip joint...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28045874/surgical-treatment-for-failure-of-repair-of-patellar-and-quadriceps-tendon-rupture-with-ipsilateral-hamstring-tendon-graft
#15
REVIEW
Nicola Maffulli, Rocco Papalia, Guglielmo Torre, Vincenzo Denaro
Tears of the patellar and quadriceps tendon are common in the active population, especially in athletes. At present, several techniques for surgical repair and reconstruction are available. When reruptures occur, a reconstruction is mandatory. In the present paper, we describe a surgical technique for patellar and quadriceps tendon reconstruction using ipsilateral hamstring autograft. After routine hamstring tendon harvesting, the tendon ends are prepared using a whip stitch. A transverse tunnel is drilled in the midportion of the patella, the hamstring graft is passed through the patella, and firmly secured to the patellar tunnel openings with sutures...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045873/the-management-of-extensor-mechanism-disruption-after-total-knee-arthroplasty-a-systematic-review
#16
REVIEW
Nicola Maffulli, Filippo Spiezia, Luca La Verde, Michele Attilio Rosa, Francesco Franceschi
We performed a literature search on PubMed, Web of Science, Science Direct/Scopus, Google Scholar, and Google to evaluate results of several techniques to manage disruption of the extensor mechanism after total knee arthroplasty. Different methods to manage extensor mechanism disruption are available at present, with no level I studies informing surgeons in an evidence-based fashion. Primary repair is not indicated. Allograft reconstruction could be effective, providing that appropriate surgical technique and allograft tensioning are implemented...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045872/revision-surgery-for-failed-patellar-tendinopathy-exploration
#17
REVIEW
Nicola Maffulli, Alessio Giai Via, Francesco Oliva
Chronic patellar tendinopathy affects athletes, with a higher incidence in high-impact sporting activities. It can seriously impair sports activities. Many patients respond well to conservative treatment, but about 10% of them are refractory to conservative treatment. In these cases, surgery is indicated. Multiple surgical techniques have been reported, including both open and arthroscopic procedures with good results. However, in a small percentage of patients surgery is unsuccessful. This group of patients presents a major challenge, as options are limited...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045870/preoperative-planning-for-acl-revision-surgery
#18
REVIEW
Leonardo Osti, Matteo Buda, Raffaella Osti, Leo Massari, Nicola Maffulli
The number of patients undergoing revision surgery following failure of anterior cruciate ligament (ACL) reconstruction has increased over the recent past, following the overall increased number of primary ACL reconstruction performed. Failure of primary ACL reconstruction can be attributed to technical errors, biological failures, or new traumatic injuries. Technical errors include femoral and/or tibial tunnels malposition, untreated associated ligaments insufficiencies, uncorrected lower limb malalignment, and graft fixation failures...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045866/revision-surgery-of-the-knee
#19
EDITORIAL
Nicola Maffulli
No abstract text is available yet for this article.
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28002825/from-common-to-rare-variants-the-genetic-component-of-alzheimer-disease
#20
REVIEW
Gaël Nicolas, Camille Charbonnier, Dominique Campion
Alzheimer disease (AD) is a remarkable example of genetic heterogeneity. Extremely rare variants in the APP, PSEN1, or PSEN2 genes, or duplications of the APP gene cause autosomal dominant forms, generally with complete penetrance by the age of 65 years. Nonautosomal dominant forms are considered as a complex disorder with a high genetic component, whatever the age of onset. Although genetically heterogeneous, AD is defined by the same neuropathological criteria in all configurations. According to the amyloid cascade hypothesis, the Aβ peptide, which aggregates in AD brains, is a key player...
2016: Human Heredity
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