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Nicola Maffulli

Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
Nicola Maffulli
No abstract text is available yet for this article.
September 8, 2016: Clinical Orthopaedics and related Research
Amol Saxena, Andrew Yun, Rajan Patel, Ludger Gerdesmeyer, Nicola Maffulli
The purpose of the present study was to evaluate the efficacy of radial soundwave therapy (RSW) for the management of sesamoiditis, symptomatic bipartite sesamoids, and avascular necrosis in athletic patients. The data from 10 patients undergoing RSW for sesamoiditis were retrospectively studied. Three treatments at 2.4 Bar and 13 Hz, for a total of 2500 pulses in each session, were administered to the affected sesamoid approximately 1 week apart. The Roles and Maudsley score and the visual analog scale (VAS) were used to assess disability and pain...
September 8, 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Francesco Smeraglia, Angelo Del Buono, Nicola Maffulli
INTRODUCTION: Fractures of the distal radius account for 15% of all fractures. The use of arthroscopy is increasingly popular in the last years, with the goal to achieve a better anatomical reduction of the articular fragments. SOURCES OF DATA: We searched the literature on Medline (PubMed), Web of Science and Scopus databases using the combined keywords 'wrist', 'distal radial fracture', 'distal radius fracture' and 'arthroscopy'. Twenty-eight studies were identified...
September 2016: British Medical Bulletin
Francesco Oliva, Eleonora Piccirilli, Anna C Berardi, Umberto Tarantino, Nicola Maffulli
Tendinopathies have a multifactorial etiology driven by extrinsic and intrinsic factors. Recent studies have elucidated the importance of thyroid hormones in the alteration of tendons homeostasis and in the failure of tendon healing after injury. The effects of thyroid hormones are mediated by receptors (TR)-α and -β that seem to be ubiquitous. In particular, T3 and T4 play an antiapoptotic role on tenocytes, causing an increase in vital tenocytes isolated from tendons in vitro and a reduction of apoptotic ones; they are also able to influence extra cellular matrix proteins secretion in vitro from tenocytes, enhancing collagen production...
2016: Advances in Experimental Medicine and Biology
Laura Stefani, Giorgio Galanti, Johnny Padulo, Nicola L Bragazzi, Nicola Maffulli
Sexual activity before competition has been considered as a possible cause for reduced performance since ancient Greece and Rome. Recently, the hypothesis that optimal sport performance could be influenced by a variety of factors including sexual activity before competition has been investigated. However, few scientific data are available, with the exception of anecdotal reports of individual experiences. The present systematic review focused on the current scientific evidence on the effects of sexual activity on sport performance regardless of sport type...
2016: Frontiers in Physiology
Johnny Padulo, Giuseppe Attene, Luca P Ardigò, Nicola L Bragazzi, Nicola Maffulli, Alessandro M Zagatto, Antonio Dello Iacono
OBJECTIVE: To investigate the effects of fatigue induced by a repeated sprint ability (RSA) test on the neuromuscular responses of soccer players with a recent history of lower limb injuries (CH) and a matched control group in good fitness condition (GH). DESIGN: This was a case-control study. PARTICIPANTS: Nine CH and 9 GH. INDEPENDENT VARIABLE: Allocation to CH or GH. MAIN OUTCOME MEASURES: Each player was assessed for blood lactate concentration and jumping performance [squat jump (SJ) and countermovement jump (CMJ)] before/after RSA...
July 15, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Stefania Schiavone, Maria G Morgese, Emanuela Mhillaj, Maria Bove, Angelo De Giorgi, Francesco P Cantatore, Claudia Camerino, Paolo Tucci, Nicola Maffulli, Vincenzo Cuomo, Luigia Trabace
Chronic psychosocial stress is a key player in the onset and aggravation of mental diseases, including psychosis. Although a strong association between this psychiatric condition and other medical co-morbidities has been recently demonstrated, few data on the link between psychosis and bone homeostasis are actually available. The aim of this study was to investigate whether chronic psychosocial stress induced by 4 or 7 weeks of social isolation in drug-naïve male Wistar rats could alter bone homeostasis in terms of bone thickness, mineral density and content, as well as markers of bone formation and resorption (sclerostin, cathepsin K, and CTX-I)...
2016: Frontiers in Pharmacology
Terence Wai-Kit Chan, Chi-Chung Kong, Angelo Del Buono, Nicola Maffulli
BACKGROUND: there is need to ascertain clinical and imaging outcomes after posterior cruciate ligament (PCL) augmentation. METHODS: we performed a retrospective analysis of clinical, imaging and functional data on 21 physically active males who underwent arthroscopic trans-tibial augmentation of the PCL for symptomatic grade III PCL insufficiency. The average follow-up time was 50 months (24-60 months). The Lysholm knee score was administered to all the patients, ligament laxity was evaluated with the posterior drawer test, the KT-1000 arthrometer, and the anteromedial tibial step-off...
January 2016: Muscles, Ligaments and Tendons Journal
Johnny Padulo, Francesco Oliva, Antonio Frizziero, Nicola Maffulli
The proper design and implementation of a study as well as a balanced and well-supported evaluation and interpretation of its main findings are of crucial importance when reporting and disseminating research. Also accountability, funding acknowledgement and adequately declaring any conflict of interest play a major role in science. Since the Muscles, Ligaments and Tendons Journal (MLTJ) is committed to the highest scientific and ethical standards, we encourage all Authors to take into account and to comply, as much as possible, to the contents and issues discussed in this official editorial...
January 2016: Muscles, Ligaments and Tendons Journal
Francesco Sadile, Alessio Bernasconi, Sergio Russo, Nicola Maffulli
INTRODUCTION: Osteonecrosis of femoral head (ONFH) leads to hip osteoarthritis (HOA); among joint preserving treatments (JPT), the role of core decompression (CD) is still debated. We assessed the efficacy of CD compared with all other JPT in delaying the natural osteonecrosis evolution to HOA. SOURCES OF DATA: Following the PRISMA checklist, the Medline and Scopus databases were searched. Fifteen- to 70-year-old subjects with ONFH with a minimum follow-up of 24 months were considered...
June 2016: British Medical Bulletin
Giovanna Della Porta, Roberta Campardelli, Vincenzo Cricchio, Francesco Oliva, Nicola Maffulli, Ernesto Reverchon
Supercritical emulsion extraction (SEE) is proposed as a green and effective strategy for the fabrication of chitosan-covered poly-lactic-co-glycolic acid (chi-PLGA) injectable microcapsules for the controlled release of teriparatide (THA) and teriparatide/gentamicin sulfate (THA/Gen). These formulations can be used for locally bone pathologies treatment or in complex fracture healing of aged patients. Several oil-water (o-w) and water-oil-water (w-o-w) emulsions were processed by SEE to produce multifunctional microcapsules containing hydroxyapatite (HA) within a poly-lactic-co-glycolic acid (PLGA) matrix (up to 24 mg/g) and with both THA (0...
July 2016: Journal of Pharmaceutical Sciences
Mohamed Chedly Jlid, Nicola Maffulli, Nisar Souissi, Mohamed Souheil Chelly, Thierry Paillard
BACKGROUND: The postural and neuromuscular performances in healthy children taekwondo (TKD) practitioners in comparison with control children were examined. METHODS: Seventeen healthy pre-pubertal males undertaking only physical education at school (age: 11.88 ± 0.33 years) and 12 pre-pubertal male TKD practitioners (>3 years, 4 sessions a week) (age 11.66 ± 0.49 years) were recruited. Performances in the dynamic postural control (Star Excursion Balance Test -SEBT), vertical jump [squat jump (SJ) and countermovement jump (CMJ)] and sprint running (distances: 5, 10, 20 and 30 m) tests were compared between the two groups...
2016: BMC Sports Science, Medicine and Rehabilitation
Nicola Maffulli, Mattia Loppini, Filippo Spiezia, Alessio D'Addona, Gayle D Maffulli
BACKGROUND: Chronic exertional compartment syndrome (CECS) involves a painful increase in compartment pressure caused by exercise and relieved by rest, common in athletes. The most common site for CECS in the lower limbs is the anterior leg compartment. The aim of this study is to evaluate the outcomes of a single minimal incision fasciotomy in athletes and their capability to return to high level sport activity. METHODS: The study reports mid-term results in a series of 18 consecutive athletes with chronic exertional compartment syndrome of the leg who had undergone minimally invasive fasciotomy...
2016: Journal of Orthopaedic Surgery and Research
Francesco Smeraglia, Angelo Del Buono, Nicola Maffulli
INTRODUCTION: In the last few years, the use of collagenase clostridium histolyticum for management of Dupuytren's contracture has increased. The procedure of enzymatic fasciectomy has become popular because it is non-invasive, safe and fast to perform. SOURCES OF DATA: A systematic search was performed on Medline (PubMed), Web of Science and Scopus databases using the combined keywords 'Dupuytren collagenase' and 'Dupuytren clostridium histolyticum'. Forty-three studies were identified...
June 2016: British Medical Bulletin
Leonardo Osti, Matteo Buda, Francesco Soldati, Angelo Del Buono, Raffaella Osti, Nicola Maffulli
INTRODUCTION: Arthroscopy procedures are the gold standard for the management of tibial spine avulsion. This review evaluates and compares different arthroscopic treatment options for tibial spine fractures. SOURCE OF DATA: PubMed, Medline, Ovid, Google Scholar and Embase databases were systematically searched with no limit regarding the year of publication. AREAS OF AGREEMENT: An arthroscopic approach compared with arthrotomy reduces complications such as soft-tissue lesions, post-operative pain and length of hospitalization...
June 2016: British Medical Bulletin
Roberto Zambelli, Rafael Z Pinto, João Murilo Brandão Magalhães, Fernando Araujo Silva Lopes, Rodrigo Simões Castilho, Daniel Baumfeld, Thiago Ribeiro Teles Dos Santos, Nicola Maffulli
BACKGROUND: There is a need for a patient-relevant instrument to evaluate outcome after treatment in patients with a total Achilles tendon rupture. The purpose of this study was to undertake a cross-cultural adaptation of the Achilles Tendon Total Rupture Score (ATRS) into Brazilian Portuguese, determining the test-retest reliability and construct validity of the instrument. METHODS: A five-step approach was used in the cross-cultural adaptation process: initial translation (two bilingual Brazilian translators), synthesis of translation, back-translation (two native English language translators), consensus version and evaluation (expert committee), and testing phase...
2016: BMC Sports Science, Medicine and Rehabilitation
Florian Guisier, Mathieu Salaün, Samy Lachkar, Aude Lamy, Nicolas Piton, Bérengère Obstoy, Jean-Christophe Sabourin, Luc Thiberville
BACKGROUND AND OBJECTIVE: Treatment optimization of non-squamous non-small-cell lung cancers (nonSq-NSCLC) relies on the molecular analysis of the tumour. We aimed to assess the predictive factors of molecular analysis feasibility (MAF) from samples of peripheral nonSq-NSCLC obtained by radial endobronchial ultrasound bronchoscopy (r-EBUS) and 1.5 mm microbiopsy forceps. METHODS: We reviewed data from consecutive peripheral lung nodules sampled with r-EBUS between January 2012 and July 2014 at a single French University Hospital...
May 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Ricard Pruna, Rosa Artells, Matilda Lundblad, Nicola Maffulli
PURPOSE: Damage to skeletal muscle necessitates regeneration to maintain proper muscle form and function. Interindividual differences in injury severity, recovery time, and injury rate could be explained by the presence of single nucleotide polymorphisms (SNPs) in genes involved in the reparation and regeneration of connective tissue . We wished to identify new genetic biomarkers that could help to prevent or minimize the risk of non-contact muscle injuries and are associated with a predisposition to developing muscle injuries...
April 16, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Antonio Frizziero, Filippo Vittadini, Michele Barazzuol, Giuseppe Gasparre, Paolo Finotti, Andrea Meneghini, Nicola Maffulli, Stefano Masiero
BACKGROUND: Rotator cuff tendinopathy is the most common cause of painful shoulder. The treatment is mainly conservative and several therapeutic approaches have been proposed, including NSAIDs, physiotherapy, injections and physical therapies. The aim of the current study is to compare the clinical effectiveness of low molecular weight hyaluronic acid (LMW-HA) injection versus low-energy Extracorporeal Shock-Wave Therapy (ESWT) until 3 months of follow-up for the management of painful non-calcific rotator cuff tendinopathies, evaluating also the trend over time between the groups...
April 12, 2016: Journal of Sports Medicine and Physical Fitness
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