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Nicola Maffulli

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https://www.readbyqxmd.com/read/29300224/achilles-tendinopathy
#1
Umile Giuseppe Longo, Mario Ronga, Nicola Maffulli
Achilles tendinopathy is a common cause of disability. Despite the economic and social relevance of the problem, the causes and mechanisms of Achilles tendinopathy remain unclear. Tendon vascularity, gastrocnemius-soleus dysfunction, age, sex, body weight and height, pes cavus, and lateral ankle instability are considered common intrinsic factors. The essence of Achilles tendinopathy is a failed healing response, with haphazard proliferation of tenocytes, some evidence of degeneration in tendon cells and disruption of collagen fibers, and subsequent increase in noncollagenous matrix...
March 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29300106/advances-with-platelet-rich-plasma-therapies-for-tendon-regeneration
#2
Isabel Andia, Jose Ignacio Martin, Nicola Maffulli
PRPs can be used in the management of tendinopathy if we improve our understanding of pathophysiology and achieve to integrate molecular knowledge about PRP participation in healing mechanisms. Areas covered: We provide new insights into the pathophysiology of tendinopathy, PRP therapies, and the potential links between both. We discuss the place of PRP in promoting tendon repair within what is currently understood of the role of PRP molecules in promoting tendon regeneration. We also highlight the many opportunities for further exploration and identification of strategically designed treatments providing meaningful clinical benefit...
January 4, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29284452/screw-migration-and-oesophageal-perforation-after-surgery-for-osteosarcoma-of-the-cervical-spine
#3
Luca Denaro, Umile Giuseppe Longo, Alberto Corrado Di Martino, Nicola Maffulli, Vincenzo Denaro
BACKGROUND: Even though internal fixation has expanded the indications for cervical spine surgery, it carries the risks of fracture or migration, with associated potential life threatening complications. Removal of metal work from the cervical spine is required in case of failure of internal fixation, but it can become challenging, especially when a great amount of scar tissue is present because of previous surgery and radiotherapy. CASE PRESENTATION: We report a 16 year old competitive basketball athlete who underwent a combined anterior and posterior approach for resection of an osteosarcoma of the sixth cervical vertebra...
December 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29186357/outcome-of-ankle-arthrodesis-and-ankle-prosthesis-a-review-of-the-current-status
#4
Nicola Maffulli, Umile Giuseppe Longo, Joel Locher, Giovanni Romeo, Giuseppe Salvatore, Vincenzo Denaro
Introduction: In advanced stages of ankle osteoarthritis (OA), ankle arthrodesis (AA) or total ankle arthroplasty (TAR) may be necessary. Our purpose is to compare AA and total ankle replacement for the surgical management of end stage ankle OA. Sources of data: We conducted a literature search of PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar databases using the terms 'ankle' in combination with 'OA', 'arthrodesis', 'arthroplasty', 'joint fusion', 'joint replacement'...
November 23, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29081863/chronic-achilles-tendon-rupture
#5
REVIEW
Nicola Maffulli, Alessio Giai Via, Francesco Oliva
BACKGROUND: The Achilles tendon, the largest and strongest tendon in the human body, is nevertheless one of the tendons which most commonly undergoes a complete subcutaneous tear. Achilles tendon ruptures are especially common in middle aged men who occasionally participate in sport. Even though Achilles tendon ruptures are frequent, up to 25% of acute injuries are misdiagnosed, and present as chronic injuries. METHODS: This is a review article about diagnosis and management of chronic Achilles tendon ruptures...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29022895/impairment-of-ptx3-expression-in-osteoblasts-a-key-element-for-osteoporosis
#6
Manuel Scimeca, Antonietta Salustri, Elena Bonanno, Daniela Nardozi, Cecilia Rao, Eleonora Piccirilli, Maurizio Feola, Virginia Tancredi, Annamaria Rinaldi, Giovanni Iolascon, Augusto Orlandi, Elena Gasbarra, Nicola Maffulli, Maria Luisa Brandi, Umberto Tarantino
Pentraxin 3 (PTX3) is a multifunctional glycoprotein regulating inflammatory response, cell proliferation and migration and deposition and remodelling of the extracellular matrix by a variety of cells. In this study, we investigated the possible role of PTX3 in bone homeostasis. To this end, we compared the expression and function of PTX3 in human osteoblasts of osteoporotic, osteoarthritic patients and young subjects not affected by bone diseases. Immunohistochemical analysis performed on bone head biopsies showed a close association between bone health and the number of osteoblasts expressing PTX3...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28914104/influence-of-previous-body-mass-index-and-sex-on-regional-fat-changes-in-a-weight-loss-intervention
#7
Pedro J Benito, Rocio Cupeiro, Ana B Peinado, Miguel A Rojo, Nicola Maffulli
OBJECTIVES: Men and women may lose weight in a different fashion. This study compares the changes in different anatomical regions after a well-controlled weight loss program by sex and initial BMI. METHODS: A total of 180 subjects (48 overweight women, 36 overweight men, and 48 obese women and 48 obese men) were recruited to participate in a 22-week weight loss programme (diet + exercise). RESULTS: Regarding percentage body weight change from baseline, there was no triple interaction (BMI, sex and anatomical region), but there was interaction between BMI and anatomical region (F2,840 = 34...
October 5, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28910993/transtendon-repair-in-partial-articular-supraspinatus-tendon-tear
#8
Leonardo Osti, Matteo Buda, Mattia Andreotti, Raffaella Osti, Leo Massari, Nicola Maffulli
Introduction: Partial thickness rotator cuff tears (PTRCTs) are common, with an incidence between 17% and 37%, and a high prevalence in throwing athletes. Different surgical procedures are suggested when partial tears involve the articular portion of the rotator cuff, including arthroscopic debridement of the tear, debridement with acromioplasty, tear completion and repair, and lately transtendon repair. This systematic review describes the transtendon repair and examines indications, contraindications, complications and clinical outcome...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28910987/management-of-combined-injuries-of-the-posterior-cruciate-ligament-and-posterolateral-corner-of-the-knee-a-systematic-review
#9
Stefano Petrillo, Piero Volpi, Rocco Papalia, Nicola Maffulli, Vincenzo Denaro
Background: Approximately 60% of posterior cruciate ligament (PCL) injury are associated with a posterolateral corner (PLC) tear. Sources of data: We performed a systematic review of the literature according to the PRISMA guidelines. The following key words were searched on Medline, Cochrane, EMBASE, Google Scholar, and Ovid: 'posterior cruciate ligament' or 'PCL' with 'posterolateral corner' or 'PLC' and 'chronic'; 'injury'; 'management'; 'reconstruction'; 'outcomes'; 'complications'...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28899898/investigating-the-association-of-rs2910164-with-cancer-predisposition-in-an-irish-cohort
#10
T P McVeigh, R J Mulligan, U M McVeigh, P W Owens, N Miller, M Bell, F Sebag, C Guerin, D S Quill, J B Weidhaas, M J Kerin, A J Lowery
INTRODUCTION: MicroRNAs (miRNAs) are small noncoding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger RNA (mRNA). Polymorphisms in genes encoding miRNAs or in miRNA-mRNA binding sites confer deleterious epigenetic effects on cancer risk. miR-146a has a role in inflammation and may have a role as a tumour suppressor. The polymorphism rs2910164 in the MIR146A gene encoding pre-miR-146a has been implicated in several inflammatory pathologies, including cancers of the breast and thyroid, although evidence for the associations has been conflicting in different populations...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28879556/we-are-operating-too-much
#11
EDITORIAL
Nicola Maffulli
With the increase of superspecialisation, there has been a recent trend for a rising number of operations for both trauma and orthopaedic ailments. This flies against the results of properly planned, well performed, adequately powered, with clinically relevant outcome measures and long enough follow-up level I studies which challenge the received wisdom that surgery is actually superior to conservative management or even supervised neglect. This editorial outlines some of these issues, and suggests that orthopaedic and trauma surgeons should actually think twice before operating on anything that comes our way...
September 6, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28842103/treatment-of-plantar-fasciitis-with-radial-soundwave-early-is-better-than-after-6%C3%A2-months-a-pilot-study
#12
Amol Saxena, Brian K Hong, Andrew S Yun, Nicola Maffulli, Ludger Gerdesmeyer
Extracorporeal shock wave therapy/radial soundwave therapy has been predominantly used for chronic or recalcitrant plantar fasciitis with strong scientific evidence of reliable outcomes. Most of the studies included patients with plantar fasciitis with symptoms >6 months in duration. Only 2 known studies have investigated acute plantar fasciitis, which is <6 weeks in duration. They both found suboptimal results for the use of extracorporeal shock wave therapy. To the best of our knowledge, no studies have investigated radial soundwave therapy for the subacute stage or early stage of plantar fasciitis...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28842099/surgery-for-tendinopathy-of-the-main-body-of-the-achilles-tendon-no-need-to-look-for-new-solutions-when-the-old-ones-work-if-performed-well
#13
EDITORIAL
Nicola Maffulli
No abstract text is available yet for this article.
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28810893/subcutaneous-emphysema-of-the-leg-after-hardware-removal-and-bone-allografting-for-infected-non-union-of-the-distal-femur
#14
Vincenzo Denaro, Umile Giuseppe Longo, Giuseppe Salvatore, Vincenzo Candela, Nicola Maffulli
BACKGROUND: Infected non-unions of the supracondylar region of the femur are uncommon. Even though hardware removal is a common procedure, it may lead to complications, including neurovascular injury, refracture, worsening pain or recurrence of deformity. CASE PRESENTATION: We report on a male who developed subcutaneous emphysema of the leg after hardware removal and bone allografting for an infected non-union of the distal femur. He was managed by debridement of the surgical wound, antibiotic therapy, multiple fasciotomies, and application of a VAC (vacuum-assisted closure) system...
August 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28810258/prevalence-of-hyponatremia-in-patients-with-elderly-hip-fracture-a-two-year-study
#15
Rocco Aicale, Domiziano Tarantino, Nicola Maffulli
OBJECTIVE: This study investigated the prevalence of hyponatremia in elderly patients (≥ 65 years) with hip fractures. SUBJECTS AND METHODS: All records containing clinical and laboratory information of the 334 elderly patients admitted with hip fractures to the San Giovanni di Dio e Ruggi d'Aragona Hospital of Salerno (Italy) during 2014 and 2015 were retrieved from the hospital database. Patients were divided into 4 different groups, according to sex and type of hip fracture...
August 14, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28733951/corr-insights-%C3%A2-is-dual-semitendinosus-allograft-stronger-than-turndown-for-achilles-tendon-reconstruction-an-in-vitro-analysis
#16
Nicola Maffulli
No abstract text is available yet for this article.
October 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28717624/ipsilateral-hamstring-tendon-graft-reconstruction-for-chronic-patellar-tendon-ruptures-surgical-technique
#17
Nicola Maffulli, Angelo Del Buono, Francesco Oliva
BACKGROUND: Patellar tendon chronic ruptures are more debated to manage that acute injuries as the patella tends to retract proximally (after 2 weeks), and surrounding soft tissues may make the repair more complicate. PURPOSE: We propose a novel technique in which the patellar tendon is reconstructed using ipsilateral hamstring tendons. This surgical procedure implies to drill a single tunnel through the patella and another through the tibia to reduce the risk of bony breakage...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717615/outcomes-of-prolotherapy-for-intra-tendinous-achilles-tears-a-case-series
#18
Otto Chan, Ben Havard, Sarah Morton, Mel Pritchard, Nicola Maffulli, Tom Crisp, Nat Padhiar, Jeremy David Perry, John King, Dylan Morrissey
BACKGROUND: The intra-tendinous tear is a new pathology that is defined as a discontinuity of fibres situated entirely within the tendon. Prolotherapy involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain. METHODS: 43 consecutive patients diagnosed with an intra-tendinous tear were included (27 males: 16 females, mean (SD) age 41 (11.3). Patients were injected with 0.4ml-1.5ml (mean 0.8ml) of 50% dextrose and 0...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717612/intratendinous-tears-of-the-achilles-tendon-a-new-pathology-analysis-of-a-large-4-year-cohort
#19
Otto Chan, Sarah Morton, Mel Pritchard, Tina Parkes, Peter Malliaras, Tom Crisp, Nat Padhiar, Nicola Maffulli, John King, Dylan Morrissey
BACKGROUND: Achillodynia is common and includes Achilles tendinopathy, partial Achilles tears and Achilles tendon ruptures. However, we believe an additional pathology should be considered for Achillodynia differentials - the intratendinous tear (ITT). METHODS: Examinations of 740 achillodynic patients in one specialist centre were reviewed. ITTs were defined as a clearly visualised echopoor area situated centrally and extending to, but not through the tendon periphery, with pain on palpation and no clinical findings consistent with Achilles rupture...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717611/conservative-minimally-invasive-and-open-surgical-repair-for-management-of-acute-ruptures-of-the-achilles-tendon-a-clinical-and-functional-retrospective-study
#20
Gayle Maffulli, Angelo Del Buono, Paula Richards, Francesco Oliva, Nicola Maffulli
BACKGROUND: At present, it is unclear which is the best management for Achilles tendon rupture. PURPOSE: We assess the clinical, functional and imaging outcomes of active patients undergoing 3 different types of management for acute subcutaneous rupture of the Achilles tendon, including conservative cast immobilization, traditional open surgery and percutaneous repair. METHODS: 26 active patients were managed for a rupture of the Achilles Tendon from January 2007 to March 2008...
January 2017: Muscles, Ligaments and Tendons Journal
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