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Nicola Maffulli

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https://www.readbyqxmd.com/read/28528351/the-influence-of-critical-shoulder-angle-on-secondary-rotator-cuff-insufficiency-following-shoulder-arthroplasty
#1
Simone Cerciello, Andrew Paul Monk, Enrico Visonà, Stefano Carbone, Thomas Bradley Edwards, Nicola Maffulli, Gilles Walch
INTRODUCTION: Secondary cuff failure after shoulder replacement is disabling and often requires additional surgery. Increased critical shoulder angle (CSA) has been found in patients with cuff tear compared to normal subjects. The interobserver reliability of the CSA and the relationship between CSA and symptomatic secondary cuff failure after shoulder replacement were investigated. MATERIALS AND METHODS: Nineteen patients with symptomatic cuff failure after anatomic shoulder replacement (mean FU 45 months) were compared to a control group of 29 patients showing no signs of symptomatic cuff failure (mean FU 105...
May 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28525564/radiofrequency-energy-in-the-arthroscopic-treatment-of-knee-chondral-lesions-a-systematic-review
#2
Rocco Papalia, Lorenzo Diaz Balzani, Guglielmo Torre, Michele Paciotti, Nicola Maffulli, Vincenzo Denaro
No abstract text is available yet for this article.
May 19, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28499877/novel-superparamagnetic-micro-devices-based-on-magnetised-plga-pla-microparticles-obtained-by-supercritical-fluid-emulsion-and-coating-by-carboxybetaine-functionalised-chitosan-allowing-the-tuneable-release-of-therapeutics
#3
Cricchio Vincenzo, Mark Best, Ernesto Reverchon, Nicola Maffulli, Gary Phillips, Matteo Santin, Della Porta Giovanna
When superparamagnetic nanoparticles are loaded within micro-carriers of thermosensitive and injectable biopolymers, "smart" microdevices are obtained: they respond to an external magnetic field (EMF) through the release of any co-encapsulated molecules with a remote on-off control. Creating reliable and effective fabrication technologies for the production of these smart nano/micro-devices remains a challenge. In this work Supercritical Emulsion Extraction technology (SEE) is proposed for the fabrication of microcapsules with a core of poly-lactic-co-glycolic acid (PLGA) or poly-lactic acid (PLA) covered by carboxybetaine-functionalized chitosan (f-chi) and loaded with paramagnetic nanoparticles (MAG, mean size of 6...
May 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28448428/therapeutic-ultrasound-in-navicular-stress-injuries-in-elite-track-and-field-athletes
#4
Nikolaos Malliaropoulos, Dimosthenis Alaseirlis, George Konstantinidis, Agapi Papalada, Ioannis Tsifountoudis, Kosmas Petras, Nicola Maffulli
OBJECTIVE: To ascertain whether therapeutic ultrasound (TUS) can be used to assess the progression of conservative management in navicular stress injuries. DESIGN: This is a prospective, clinical case series. Level of evidence IV. SETTING: All participants were examined and followed up in a private Sports Injury Clinic. PARTICIPANTS: Ten elite track and field athletes with severe dorsal midfoot pain over the navicular bone participated in this study...
May 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28401805/an-engineered-multiphase-3d-microenvironment-to-ensure-the-controlled-delivery-of-cyclic-strain-and-hgdf-5-for-the-tenogenic-commitment-of-hbmscs
#5
Marco Govoni, Anna Berardi, Claudio Muscari, Roberta Campardelli, Francesca Bonafè, Carlo Guarnieri, Ernesto Reverchon, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
At present, injuries or rupture of tendons are treated by surgical repair or conservative approaches with unpredictable clinical outcome. Alternative strategies to repair tendon defects without the undesirable side effects associated with the current options are needed. With this in mind, a tissue engineering approach has gained considerable attention as a promising strategy. Here, we investigated a synthetic 3D microenvironment able to interact with stem cells and inducing, via coupled biochemical and physical signals, their early commitment towards the tenogenic lineage...
April 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28369181/apoptosis-and-rotator-cuff-tears-scientific-evidence-from-basic-science-to-clinical-findings
#6
Leonardo Osti, Matteo Buda, Angelo Del Buono, Raffaella Osti, Leo Massari, Nicola Maffulli
Introduction: Excessive apoptosis has been hypothesized as possible cause of tendinopathy and tear in the tendons of the rotator cuff (RC). Different mechanisms and molecules play a key role in cell regulation. Biological interventions can affect the process of apoptosis to control the tendinopathy process, and may be useful to design new treatments. Source of data: We identified basic science, in vitro and in vivo preclinical and clinical studies listed in the Pubmed Google Scholar, CINAHL, Cochrane Central and Embase Biomedical databases in English, Spanish, Italian and French concerning the effects of apoptosis on RC tendons...
March 24, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334196/the-effectiveness-of-prolotherapy-in-treating-knee-osteoarthritis-in-adults-a-systematic-review
#7
Fadi Hassan, Suad Trebinjac, William D Murrell, Nicola Maffulli
Introduction: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise. Sources of data: Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016...
March 4, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334148/surgical-versus-conservative-management-of-type-iii-acromioclavicular-dislocation-a-systematic-review
#8
Umile Giuseppe Longo, Mauro Ciuffreda, Giacomo Rizzello, Nicholas Mannering, Nicola Maffulli, Vincenzo Denaro
Introduction: The management of Type III acromioclavicular (AC) dislocations is still controversial. We wished to compare the rate of recurrence and outcome scores of operative versus non-operative treatment of patients with Type III AC dislocations. Source of data: A systematic review of the literature was performed by applying the PRISMA guidelines according to the PRISMA checklist and algorithm. A search in Medline, PubMed, Cochrane and CINAHL was performed using combinations of the following keywords: 'dislocation', 'Rockwood', 'type three', 'treatment', 'acromioclavicular' and 'joint'...
February 27, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28125768/a-versatile-and-highly-selective-colorimetric-sensor-for-the-detection-of-amines
#9
Yvonne J Diaz, Zachariah A Page, Abigail S Knight, Nicolas J Treat, James R Hemmer, Craig J Hawker, Javier Read de Alaniz
The utility of Meldrum's activated furan (MAF) for the colorimetric detection of sub ppm levels of amines in solution, on solid supports, and as vapors is reported. MAF is synthesized in one step from inexpensive and commercially available starting materials and exhibits high selectivity for primary and secondary amines in the presence of competing nucleophiles. The reaction between activated furans and amines results in a distinct color change, discernable by the naked eye. UV/Vis absorption spectroscopy was utilized to monitor reactions in solution and determine detection limits...
March 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28066733/viscosupplementation-with-intra-articular-hyaluronic-acid-for-hip-disorders-a-systematic-review-and-meta-analysis
#10
Eleonora Piccirilli, Francesco Oliva, Mihaela Aconstantinesei Murè, Asmaa Mahmoud, Calogero Foti, Umberto Tarantino, Nicola Maffulli
BACKGROUND: Hip joint diseases are common in adult population and their prevalence increases with age. Osteoarthritis, rheumatoid arthritis and femoroacetabular impingement are the most common chronic diseases in the hip joint. Viscosupplementation with exogenous hyaluronic acid (HA) is one of the most widely used conservative treatment aiming to improve synovial fluid properties and to decrease pain. There is no global consensus on the type of HA, method of injection and frequency, or on its efficacy in hip joint...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28045874/surgical-treatment-for-failure-of-repair-of-patellar-and-quadriceps-tendon-rupture-with-ipsilateral-hamstring-tendon-graft
#11
Nicola Maffulli, Rocco Papalia, Guglielmo Torre, Vincenzo Denaro
Tears of the patellar and quadriceps tendon are common in the active population, especially in athletes. At present, several techniques for surgical repair and reconstruction are available. When reruptures occur, a reconstruction is mandatory. In the present paper, we describe a surgical technique for patellar and quadriceps tendon reconstruction using ipsilateral hamstring autograft. After routine hamstring tendon harvesting, the tendon ends are prepared using a whip stitch. A transverse tunnel is drilled in the midportion of the patella, the hamstring graft is passed through the patella, and firmly secured to the patellar tunnel openings with sutures...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045873/the-management-of-extensor-mechanism-disruption-after-total-knee-arthroplasty-a-systematic-review
#12
Nicola Maffulli, Filippo Spiezia, Luca La Verde, Michele Attilio Rosa, Francesco Franceschi
We performed a literature search on PubMed, Web of Science, Science Direct/Scopus, Google Scholar, and Google to evaluate results of several techniques to manage disruption of the extensor mechanism after total knee arthroplasty. Different methods to manage extensor mechanism disruption are available at present, with no level I studies informing surgeons in an evidence-based fashion. Primary repair is not indicated. Allograft reconstruction could be effective, providing that appropriate surgical technique and allograft tensioning are implemented...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045872/revision-surgery-for-failed-patellar-tendinopathy-exploration
#13
Nicola Maffulli, Alessio Giai Via, Francesco Oliva
Chronic patellar tendinopathy affects athletes, with a higher incidence in high-impact sporting activities. It can seriously impair sports activities. Many patients respond well to conservative treatment, but about 10% of them are refractory to conservative treatment. In these cases, surgery is indicated. Multiple surgical techniques have been reported, including both open and arthroscopic procedures with good results. However, in a small percentage of patients surgery is unsuccessful. This group of patients presents a major challenge, as options are limited...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045870/preoperative-planning-for-acl-revision-surgery
#14
Leonardo Osti, Matteo Buda, Raffaella Osti, Leo Massari, Nicola Maffulli
The number of patients undergoing revision surgery following failure of anterior cruciate ligament (ACL) reconstruction has increased over the recent past, following the overall increased number of primary ACL reconstruction performed. Failure of primary ACL reconstruction can be attributed to technical errors, biological failures, or new traumatic injuries. Technical errors include femoral and/or tibial tunnels malposition, untreated associated ligaments insufficiencies, uncorrected lower limb malalignment, and graft fixation failures...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28045866/revision-surgery-of-the-knee
#15
Nicola Maffulli
No abstract text is available yet for this article.
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28002825/from-common-to-rare-variants-the-genetic-component-of-alzheimer-disease
#16
REVIEW
Gaël Nicolas, Camille Charbonnier, Dominique Campion
Alzheimer disease (AD) is a remarkable example of genetic heterogeneity. Extremely rare variants in the APP, PSEN1, or PSEN2 genes, or duplications of the APP gene cause autosomal dominant forms, generally with complete penetrance by the age of 65 years. Nonautosomal dominant forms are considered as a complex disorder with a high genetic component, whatever the age of onset. Although genetically heterogeneous, AD is defined by the same neuropathological criteria in all configurations. According to the amyloid cascade hypothesis, the Aβ peptide, which aggregates in AD brains, is a key player...
2016: Human Heredity
https://www.readbyqxmd.com/read/27993964/plasma-circulating-tumor-dna-in-pancreatic-cancer-patients-is-a-prognostic-marker
#17
Daniel Pietrasz, Nicolas Pécuchet, Fanny Garlan, Audrey Didelot, Olivier Dubreuil, Solène Doat, Francoise Imbert-Bismut, Mehdi Karoui, Jean-Christophe Vaillant, Valérie Taly, Pierre Laurent-Puig, Jean-Baptiste Bachet
PURPOSE: Despite recent therapeutic advances, prognosis of patients with pancreatic adenocarcinoma remains poor. Analyses from tumor tissues present limitations; identification of informative marker from blood might be a promising alternative. The aim of this study was to assess the feasibility and the prognostic value of circulating tumor DNA (ctDNA) in pancreatic adenocarcinoma. EXPERIMENTAL DESIGN: From 2011 to 2015, blood samples were prospectively collected from all consecutive patients with pancreatic adenocarcinoma treated in our center...
January 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27941042/apophyseal-injuries-in-children-s-and-youth-sports
#18
REVIEW
Umile Giuseppe Longo, Mauro Ciuffreda, Joel Locher, Nicola Maffulli, Vincenzo Denaro
INTRODUCTION: The authors reviewed the current English literature regarding apophyseal injuries affecting young athletes, to highlight the frequency and characteristics of these injuries, to clarify risk factors and specific prevention measures, and to identify future research objectives. SOURCES OF DATA: The authors performed a comprehensive search of the medical literature, using the Medline database, including all English articles. Various combinations of the Keywords 'injury', 'sports', 'athletic injuries', 'avulsion fractures', 'physeal', 'physis', 'apophysis', 'apophysitis', 'growth plate' were used...
December 2016: British Medical Bulletin
https://www.readbyqxmd.com/read/27900295/diagnostic-performance-of-volume-and-limited-oblique-mri-of-the-anterior-cruciate-ligament-compared-to-knee-arthroscopy
#19
Paula J Richards, Iain McCall, Alexandra Kraus, Mary Jones, Gayle Maffulli, Stephen Bridgman, Nicola Maffulli
BACKGROUND: Many strategies have been used to improve the visualisation of the ACL including sagittal, coronal oblique sequences, and 3D volume imaging. Nevertheless, the ACL may not always be visualised. METHODS: Two hundred and thirty-one consecutive patients (77 females; 154 males; average age 43.5, range 18 to 82 years; 205 with chronic, 20 acute, and 6 acute on chronic symptoms) underwent knee arthroscopy for mechanical symptoms within a week of MRI. After routine orthogonal sequences, if general MRI radiographers, with over four years experience, were not able to identify the presence of the ACL, then two 3D volume sequences and 2D limited sagittal oblique T1 sequences were performed...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27900291/elastin-a-possible-genetic-biomarker-for-more-severe-ligament-injuries-in-elite-soccer-a-pilot-study
#20
Rosa Artells, Ricard Pruna, Alexandre Dellal, Nicola Maffulli
BACKGROUND: The study of new genetic biomarkers in genes related to connective tissue repair and regeneration may help to identify individuals with greater predisposition to injury, who may benefit from targeted preventive measures, and those who require longer recovery time following a muscle, ligament or tendon injury. The present study investigated whether single nucleotide polymorphisms of the Elastin gene could be related to MCL injury. METHODS: 60 top class football players were studied to identify single nucleotide polymorphisms for the Elastin (ELN) gene using Allelic Discrimination analysis...
April 2016: Muscles, Ligaments and Tendons Journal
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