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JOURNAL ARTICLE
Xiujie Guo, Jiaying Yang, Wei Wang, Yun Gong, Peng Zhang, Mengyao Wu, Yuanqing Zheng, Chaoran Wang
Fuke Qianjin capsules (FKQJ) exhibit obvious advantages and characteristics in the treatment of pelvic inflammatory disease. At present, information regarding the in vivo process of FKQJ is lacking, which has become a bottleneck in further determining the therapeutic effect of this traditional Chinese medicine. In the present study, a sensitive, simple and reliable method was developed and validated for the simultaneous quantification of 12 main components (4 flavonoids, 4 alkaloids, 2 phthalides and 2 diterpene lactones) in plasma and seven tissues of rats to study the pharmacokinetic and distribution characteristics of these components in vivo by using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the first time...
February 23, 2024: Journal of Pharmaceutical and Biomedical Analysis
#2
JOURNAL ARTICLE
Shama Aphale, Kavita Shinde, N M Karandikar, Vijaya A Pandit, J N Mishra, Ruchika Kaul-Ghanekar
ETHNOPHARMACOLOGICAL RELEVANCE: Panchvalkala is a conventional Ayurvedic medicine used as a douche in gynecological disorders such as leucorrhea, infertility, and endometriosis. Recently, we have reported the anticancer activity of Panchvalkala aqueous extract (PVaq) in cervical cancer cell lines, SiHa (HPV16+), HeLa (HPV18+), and mouse papilloma models. AIM OF THE STUDY: Here, we have evaluated the safety of an aqueous extract of Ayurvedic formulation, Panchvalkala (PVaq), in Swiss albino mice by performing a subacute toxicity study...
October 17, 2023: Journal of Ethnopharmacology
#3
REVIEW
Amena Aktar, Bryan Heit
The transcription factor GATA2 is involved in human diseases ranging from hematopoietic disorders, to cancer, to infectious diseases. GATA2 is one of six GATA-family transcription factors that act as pioneering transcription factors which facilitate the opening of heterochromatin and the subsequent binding of other transcription factors to induce gene expression from previously inaccessible regions of the genome. Although GATA2 is essential for hematopoiesis and lymphangiogenesis, it is also expressed in other tissues such as the lung, prostate gland, gastrointestinal tract, central nervous system, placenta, fetal liver, and fetal heart...
August 25, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
#4
JOURNAL ARTICLE
Jingbo Pang, Timothy J Koh
Monocytes (Mo) and macrophages (Mϕ) play important roles in the function of tissues, organs, and systems of all animals, during homeostasis, infection, injury and disease. For decades, conventional wisdom has dictated that Mo and Mϕ are end-stage cells that do not proliferate and that Mϕ accumulation in tissues is the result of infiltration of Mo from the blood and subsequent differentiation to Mϕ. However, reports from the early 1900s to the present describe evidence of Mo and Mϕ proliferation in different tissues and contexts...
August 9, 2023: Journal of Leukocyte Biology
#5
JOURNAL ARTICLE
Shaoyang Sheng, Lin Guan, Jianping Xie, Qi Xiao, Libin Wen, Kongwang He
BACKGROUND: Porcine circovirus-like virus P1 is the animal virus with the smallest genome discovered so far, and it has become widely distributed in the Chinese mainland in recent years. RESULTS: In this study, a BALB/c mouse model was used to reveal P1 infection in female reproductive systems and the vertical transmission of the virus. The female reproductive system, including the ovary and uterus, was harvested on day 14 postinfection and examined for pathological lesions...
July 28, 2023: BMC Veterinary Research
#6
JOURNAL ARTICLE
Jie Wu, Ma-Yi-Jie Cao, Ying Peng, Bao-Hua Dong, Yun-Xiu Jiang, Peng-Jin Zhu, Chang-Jiang Hu, Run-Chun Xu, Zhi-Min Chen
This study compared the effects of Curcuma longa before and after processing with vinegar on the rat model of dysmenorrhea with the syndrome of liver depression and Qi stagnation to reveal the mechanism of vinegar processing in improving the role of C. longa in soothing liver and relieving pain. The rat model of dysmenorrhea with the syndrome of liver depression and Qi stagnation was established according to the Preparation of the Animal Model of Dysmenorrhea(Draft) and the chronic unpredictable stress me-thod...
July 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#7
JOURNAL ARTICLE
Erik Stricker, Erin C Peckham-Gregory, Michael E Scheurer
In this study, we sought to create a database summarizing the expression of human endogenous retroviruses (HERVs) in various human cancers. HERVs are suitable therapeutic targets due to their abundance in the human genome, overexpression in various malignancies, and involvement in various cancer pathways. We identified articles on HERVs from PubMed and then prescreened and automatically categorized them using the portable document format (PDF) data extractor (PDE) R package. We discovered 196 primary research articles with HERV expression data from cancer tissues or cancer cell lines...
May 31, 2023: Journal of Virology
#8
REVIEW
Andrigo Barboza De Nardi, Cristina de Oliveira Massoco Salles Gomes, Carlos Eduardo Fonseca-Alves, Felipe Noleto de Paiva, Laís Calazans Menescal Linhares, Gabriel João Unger Carra, Rodrigo Dos Santos Horta, Felipe Augusto Ruiz Sueiro, Paulo Cesar Jark, Adriana Tomoko Nishiya, Carmen Helena de Carvalho Vasconcellos, Rodrigo Ubukata, Karen Batschinski, Renata Afonso Sobral, Simone Crestoni Fernandes, Luiz Roberto Biondi, Ricardo De Francisco Strefezzi, Julia Maria Matera, Marcelo Monte Mor Rangel, Denner Santos Dos Anjos, Carlos Henrique Maciel Brunner, Renee Laufer-Amorim, Karine Germano Cadrobbi, Juliana Vieira Cirillo, Mauro Caldas Martins, Nazilton de Paula Reis Filho, Diego Fernando Silva Lessa, Roberta Portela, Carolina Scarpa Carneiro, Sílvia Regina Ricci Lucas, Heidge Fukumasu, Marcus Antônio Rossi Feliciano, Juliany Gomes Quitzan, Maria Lucia Zaidan Dagli
Hemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle tissues; visceral hemangiosarcomas can affect the spleen, liver, heart, lungs, kidneys, oral cavity, bones, bladder, uterus, tongue, and retroperitoneum. Among domestic species, dogs are most affected by cutaneous HSA. Cutaneous HSA represents approximately 14% of all HSA diagnosed in this species and less than 5% of dermal tumors, according to North American studies...
March 29, 2023: Cancers
#9
REVIEW
Sara López-Martínez, Carlos Simón, Xavier Santamaria
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating physiological conditions such as body temperature. Recent advancements in NMP system design have prompted the development of clinically effective devices for liver, heart, lung, and kidney transplantation that preserve organs for several hours/up to 1 d. In preclinical studies, adjustments to circuit structure, perfusate composition, and automatic supervision have extended perfusion times up to 1 wk of preservation. Emerging NMP platforms for ex vivo preservation of the pancreas, intestine, uterus, ovary, and vascularized composite allografts represent exciting prospects...
January 1, 2024: Transplantation
#10
JOURNAL ARTICLE
Carlos Eduardo Lacerda Ramalho, Diego Dos Santos Reis, Graziele Alícia Batista Caixeta, Micaelle Cristina de Oliveira, Danielle Milany Fernandes da Silva, Wilson de Melo Cruvinel, Monatha Nayara Guimarães Teófilo, Clayson Moura Gomes, Priscilla Abdala de Sousa, Leiza Fagundes Soares, Anielly Monteiro de Melo, Jamira Dias Rocha, Elisa Flávia Luiz Cardoso Bailão, Vanessa Cristiane Santana Amaral, Joelma Abadia Marciano de Paula
ETHNOPHARMACOLOGICAL RELEVANCE: Azadirachta indica A. Juss (Meliaceae), popularly known as "neem", is used for the treatment of rheumatism, cancer, ulcers, diabetes, respiratory problems, among others. This species is present on six continents and contains more than 400 bioactive compounds. Practically all parts of the plant are used in the treatment of diseases. Although it is widely used, no study has evaluated the safety of this species throughout the gestational period in Wistar rats...
March 22, 2023: Journal of Ethnopharmacology
#11
JOURNAL ARTICLE
Min Ji Son, Alexander Thomas, Garrett Jackson, Debini Banh, Taylor Terlizzese, James Oh, Jack Burrows, Rahul Vedantam, Shanon Quach, John Gibson
INTRODUCTION: With the introduction of portable handheld ultrasounds, higher levels of technology are more easily available for patients in rural and underserved communities. Point-of-care ultrasound (POCUS) increases accessibility for patients with limited resources, thus reducing costs and decreasing the risk of non-compliance or subsequent loss to follow-up. Despite the increasing utility of ultrasonography, literature demonstrates a lack of sufficient training in POCUS and ultrasound-guided techniques for Family Medicine residents...
January 2023: Rural and Remote Health
#12
REVIEW
Bin Wang, Tang Qinglai, Qian Yang, Mengmeng Li, Shiying Zeng, Xinming Yang, Zian Xiao, Xinying Tong, Lanjie Lei, Shisheng Li
In view of their low immunogenicity, biomimetic internal environment, tissue- and organ-like physicochemical properties, and functionalization potential, decellularized extracellular matrix (dECM) materials attract considerable attention and are widely used in tissue engineering. This review describes the composition of extracellular matrices and their role in stem-cell differentiation, discusses the advantages and disadvantages of existing decellularization techniques, and presents methods for the functionalization and characterization of decellularized scaffolds...
February 2023: Materials today. Bio
#13
REVIEW
Roua Gabriela Popescu, Andreea Luminița Rădulescu, Sergiu Emil Georgescu, Anca Dinischiotu
Feeding farm animals with aflatoxin-contaminated feed can cause various severe toxic effects, leading to increased susceptibility to infectious diseases and increased mortality, weight loss, poor performance and reduced reproductive capability. Following ingestion of contaminated foodstuffs, aflatoxins are metabolized and biotransformed differently in animals. Swine metabolism is not effective in detoxifying and excreting aflatoxins, meaning the risk of aflatoxicosis is increased. Thus, it is of great importance to elucidate the metabolism and all metabolic pathways associated with this mycotoxin...
December 3, 2022: Toxins
#14
REVIEW
Juan Antonio Camara Serrano
Refinement is one of the ethical pillars of the use of animals in research. Ultrasonography is currently used in human medicine as a surgical tool for guided biopsies and this idea can be applied to preclinical research thanks to the development of specific instruments. This will eliminate the necessity of a surgical opening for implanting cells in specific organs or taking samples from tissues. The approach for the injection will depend on the target but most of the case is going to be lateral, with the probe in a ventral position and the needle going into from the lateral...
December 6, 2022: Animals: An Open Access Journal From MDPI
#15
JOURNAL ARTICLE
Mohamad Shourmij, Javad Khalili Fard, Parvaneh Najafizadeh, Zahra Mousavi
OBJECTIVES: Quercus brantii galls (QBGs) are well-known in Iranian traditional medicine for treating various diseases. The aim of study was to assess the acute and repeated oral toxicity of the hydroalcoholic extract of QBG in female rats. MATERIALS AND METHODS: The ethanolic extract of QBG was administered in rats by gavage in both acute and repeated dose models. In the acute section of the study, a single oral dose of 2000 mg/kg was administered to female rat which were observed for physical symptoms and behavioral changes for 14 days...
November 2022: Iranian Journal of Basic Medical Sciences
#16
JOURNAL ARTICLE
Xiaofang Feng, Zhengyun Cai, Tong Mu, Baojun Yu, Ying Wang, Ruoshuang Ma, Jiaming Liu, Chuanchuan Wang, Juan Zhang, Yaling Gu
BACKGROUND: Milk fat is one of the main reference elements for evaluating milk quality and is a primary objective trait in dairy cattle breeding. In recent years, circular RNAs (circRNAs) have been found to play crucial roles in many biological processes. However, the function and expression profiles of circRNAs in milk fat synthesis in cows are not completely understood. We performed RNA sequencing to analyze the genome-wide expression of circRNA transcripts in bovine mammary epithelial cells (BMECs) from cows with extreme differences in milk fat percentage...
2022: Frontiers in Veterinary Science
#17
JOURNAL ARTICLE
Huixing Cui, Junxian Liu, Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev, Valentin A Stonik, Yinhua Zhang
We aimed to observe the effects of Echinochrome A (Ech A) on systemic changes using a rat model of preeclampsia. The results showed that an infusion of angiotensin II (Ang II) through an osmotic pump (1 μg/kg/min) on GD 8 increased systolic and diastolic blood pressures and reduced fetal weight and placental weight. The diameters of the glomeruli were expended and glomeruli capillaries were diminished. No change was observed in the heart and liver in the Ang II group, but epithelial structures were disrupted in the uterus...
November 17, 2022: Marine Drugs
#18
JOURNAL ARTICLE
Yuchen Pan, Jingman Li, Jiali Wang, Qi Jiang, Jingjing Yang, Huan Dou, Huaping Liang, Kuanyu Li, Yayi Hou
The therapeutic effect of mesenchymal stem cells (MSCs) on sepsis has been well-known. However, a comprehensive understanding of the relationship between MSCs and macrophages remains elusive. Superparamagnetic iron oxide (SPIO) is one of the most commonly used tracers for MSCs. Our previous study has shown that SPIO enhanced the therapeutic effect of MSCs in a macrophage-dependent manner. However, the fate of SPIO-labeled MSCs (MSCSPIO ) after infusion remains unknown and the direct interaction between MSCSPIO and macrophages remains unclear...
September 26, 2022: Cell Death & Disease
#19
JOURNAL ARTICLE
Ruizhe Sun, Mingming Li, Na He, Xiaocheng Wen, Junxia Zhang
SMAD4, SMAD5 and SMAD7 belonging to the transforming growth factor β (TGF-β) superfamily are indispensable for oocyte formation and development, ovarian organogenesis and folliculogenesis. However, only a few studies have investigated the characteristics of SMAD4 , SMAD5 and SMAD7 in Tibetan sheep and the effect of their polymorphism on litter size. In this study, we examined the expression of SMAD4 , SMAD5 and SMAD7 in 13 tissues of Tibetan sheep by reverse transcription-quantitative polymerase chain reaction...
August 30, 2022: Animals: An Open Access Journal From MDPI
#20
JOURNAL ARTICLE
Kanji Benson Muthee, Timothy E Maitho, Laetitia Wakonyu Kanja, Jared Misonge Onyancha
Over 80% of cultural societies in low-income countries use plant preparations in traditional medicine with unknown potency and safety profiles. Uvariodendron anisatum root extracts are used by some Kenyan herbalists. However, the claims of the plant to remove retained placenta during birth have remained uninvestigated. Therefore, the current study evaluated its uterotonic activities. Acute toxicity in Wistar rats and the phytochemical composition of the plant were also studied. The plant was collected from Embu County in Kenya...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
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