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Hydroxychloroquine

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https://www.readbyqxmd.com/read/28077146/childhood-arthritis-and-rheumatology-research-alliance-consensus-clinical-treatment-plans-for-juvenile-dermatomyositis-with-skin-predominant-disease
#1
Susan Kim, Philip Kahn, Angela B Robinson, Bianca Lang, Andrew Shulman, Edward J Oberle, Kenneth Schikler, Megan Lea Curran, Lilliana Barillas-Arias, Charles H Spencer, Lisa G Rider, Adam M Huber
BACKGROUND: Juvenile dermatomyositis (JDM) is the most common form of the idiopathic inflammatory myopathies in children. A subset of children have the rash of JDM without significant weakness, and the optimal treatments for these children are unknown. The goal of this study was to describe the development of consensus clinical treatment plans (CTPs) for children with JDM who have active skin rashes, without significant muscle involvement, referred to as skin predominant JDM in this manuscript...
January 11, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28073814/donor-derived-mycosis-fungoides-following-reduced-intensity-haematopoietic-stem-cell-transplantation-from-a-matched-unrelated-donor
#2
Francesca A M Kinsella, Mohammad Rasoul Amel Kashipaz, Julia Scarisbrick, Ram Malladi
A 46-year-old woman with a history of dasatinib-resistant chronic myeloid leukaemia, clonal evolution and monosomy 7 underwent reduced intensity conditioned in vivo T-cell-depleted allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor. Following the transplantation, she developed recurrent cutaneous graft versus host disease (GvHD), which required treatment with systemic immunosuppression and electrocorporeal photophoresis. Concurrently, she developed a lichenoid rash with granulomatous features suggestive of cutaneous sarcoidosis...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28057661/risk-and-severity-of-herpes-zoster-in-patients-with-rheumatoid-arthritis-receiving-different-immunosuppressive-medications-a-case-control-study-in-asia
#3
Tsai-Ling Liao, Yi-Ming Chen, Hung-Jen Liu, Der-Yuan Chen
OBJECTIVE: Increasing evidence indicates that the risk of herpes zoster (HZ) is elevated in rheumatoid arthritis (RA). Little is known about the epidemiology of HZ in patients with RA in Asia. The aim of this study was to determine the risk factors and outcomes of HZ among patients with RA. DESIGN: A case-control study. SETTING: A medical centre in Asia. PARTICIPANTS: A total of 9025 newly diagnosed and eligible patients with RA (International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 714...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28056758/thrombotic-management-of-antiphospholipid-syndrome-towards-novel-targeted-therapies
#4
Md Asiful Islam, Fahmida Alam, Kah Keng Wong, Mohammad Amjad Kamal, Siew Hua Gan
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis and/or pregnancy morbidity with persistent levels of antiphospholipid antibodies (aPLs). The development of thrombosis in APS is mediated by aPLs and contributes to the high mortality rate in APS patients. However, although APS has been reported for more than 30 years, there has been no optimal regimen for its prevention or for the management of thrombosis, mainly because the mainstay treatment strategies for managing APS are not targeted towards aPL-mediated thrombotic pathophysiology...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28049380/evaluation-of-tlr9-expression-on-pbmcs-and-cpg-odn-tlr9-ligation-on-ifn-%C3%AE-production-in-sle-patients
#5
Sahar Mortezagholi, Zohreh Babaloo, Parisa Rahimzadeh, Haideh Namdari, Mojgan Ghaedi, Farhad Gharibdoost, Reza Mirzaei, Katayoon Bidad, Eisa Salehi
CONTEXT: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoreactive antibodies. Recent findings revealed the importance of innate immune responses, especially Toll-like receptors (TLRs) in the pathogenesis of SLE. OBJECTIVE: In this study, the level of TLR9 expression on peripheral blood mononuclear cells (PBMCs) was analyzed. The levels of produced IFN-α were also measured in supernatant of PBMCs from SLE patients and healthy controls after stimulation with CpG ODN2216 which is a plasmocytoid dendritic cell (pDC)-specific TLR9 ligand...
January 3, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28042431/vulvovaginal-gingival-lichen-planus-report-of-two-cases-and-review-of-literature
#6
REVIEW
A Lucchese, A Dolci, G Minervini, C Salerno, D DI Stasio, G Minervini, L Laino, F Silvestre, R Serpico
PURPOSE: Oral Lichen Planus (OLP) is a chronic inflammatory disease of skin and mucous membranes. Approximately 20% of women with oral lichen planus develops lesions in the genital mucosa. In 1982, Pelisse described a special form of lichen planus (LP), which consists of a triad of symptoms: vulval, vaginal and gingival (VVG)-LP lesions. Aim of the present report is to report two new cases and review the international literature. MATERIAL AND METHODS: Two cases of VVG-LP are reported and a review of recent literature is performed...
April 2016: Oral & Implantology
https://www.readbyqxmd.com/read/28036259/subcellular-localization-of-foxo3a-as-a-potential-biomarker-of-response-to-combined-treatment-with-inhibitors-of-pi3k-and-autophagy-in-pik3ca-mutant-cancer-cells
#7
Hyun-Jung Kim, Soo Yoon Lee, Chan Young Kim, Yun Hwan Kim, Woong Ju, Seung Chloe Kim
Autophagy is the process of lysosome-mediated degradation and recycling that functions as an adaptive survival mechanism during anti-cancer therapy. Aberrant activation of the phosphoinositide-3-kinase (PI3K) pathway frequently occurs in solid tumors, including cervical cancer. However, single-agent PI3K inhibitors show modest anti-tumor efficacy in clinics. To see whether autophagy inhibition improves the efficacy of PI3K inhibitor in PIK3CA-mutant cancer cells, cells were treated with BKM120, a pan-PI3K inhibitor, and the autophagy inhibitor hydroxychloroquine (HCQ)...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029600/therapeutic-targeting-of-autophagy
#8
REVIEW
Christina G Towers, Andrew Thorburn
Autophagy is a catabolic process that facilitates nutrient recycling via degradation of damaged organelles and proteins through lysosomal mediated degradation. Alterations in this complex, and tightly regulated process, lead to disease. Autophagy is widely accepted as cytoprotective against neurodegenerative diseases and a variety of clinical interventions are moving forward to increase autophagy as a therapeutic intervention. Autophagy has both positive and negative roles in cancer and this has led to controversy over whether or how autophagy manipulation should be attempted in cancer therapy...
October 23, 2016: EBioMedicine
https://www.readbyqxmd.com/read/28025216/hydroxychloroquine-for-the-prevention-of-recurrent-cardiovascular-events-in-myocardial-infarction-patients-rationale-and-design-of-the-oxi-trial
#9
Otto Hartman, Petri T Kovanen, Jukka Lehtonen, Kari K Eklund, Juha Sinisalo
BACKGROUND: Inflammation of the arterial wall plays a central role in the pathogenesis of atherosclerosis. Among patients with rheumatic diseases, anti-rheumatic medication reduces the incidence of cardiovascular (CV) diseases, but only few studies have addressed their cardioprotective effects on patients with no rheumatic diseases. Hydroxychloroquine (HCQ) is an anti-rheumatic drug commonly used in the treatment of rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol levels and the risk of type II diabetes, and has also anti-platelet effects...
November 8, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28013435/evaluation-of-quality-indicators-and-disease-damage-in-childhood-onset-systemic-lupus-erythematosus-patients
#10
Julia G Harris, Kristyn I Maletta, Evelyn M Kuhn, Judyann C Olson
The aim of this study was to describe compliance with select quality indicators and assess organ-specific dysfunction in a childhood-onset systemic lupus erythematosus population by using a validated damage index and to evaluate associations between compliance with quality indicators and disease damage. A retrospective chart review was performed on patients diagnosed with systemic lupus erythematosus prior to age 18 followed at a single center in the USA from 1999 to 2012 (n = 75). Data regarding quality indicators and outcome variables, including the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, were collected...
December 24, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27998874/-analysis-of-pregnancy-outcomes-in-66-patients-with-systemic-lupus-erythematosus
#11
Xiu-Zhen Song, Jia-Mian Chen, Qiu-Gen Zhou
OBJECTIVE: To analyze the outcomes of pregnancies in women with systemic lupus erythematosus (SLE) and the risk factors affecting the outcomes. METHODS: The data of SLE patients with pregnancy admitted from October, 2006 and September, 2015 were analyzed for assessing the maternal and fetal outcomes and complications. Their risk factors affecting the outcomes of the pregnancies were analyzed. RESULTS: The 66 SLE patients (69 pregnancies) had a mean age at SLE diagnosis of 22...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27998301/acute-polyarthritis-in-a-young-patient-caused-by-meningococcal-and-parvovirus-b19-infections-a-case-report-and-review-of-the-literature
#12
Virginie Lavoipierre, Anna Dellyes, Camille Aubry, Christine Zandotti, Pierre Lafforgue, Philippe Parola, Jean-Christophe Lagier
BACKGROUND: Meningococcal infection is a multifaceted disease including acute polyarthritis. This presentation should be known by clinicians in order to prevent delay in treatment. We report what we believe to be the first case of an association of parvovirus B19 and meningococcal polyarthritis in a young adult. CASE PRESENTATION: A 19-year-old Caucasian woman presented to our hospital with fever, intense leg pain, and a transient rash. A physical examination showed asymmetric polyarthritis and no neurological abnormalities...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27992698/effects-of-hydroxychloroquine-on-cutaneous-lupus-erythematosus-a-multi-center-double-blind-randomized-parallel-group-trial
#13
N Yokogawa, H Eto, A Tanikawa, T Ikeda, K Yamamoto, T Takahashi, H Mizukami, T Sato, N Yokota, F Furukawa
Objectives To assess the efficacy and tolerability of hydroxychloroquine (HCQ) in a phase III clinical trial conducted in Japan Methods A double-blind randomized parallel-group clinical trial was performed. This was a baseline-controlled study and the group differences were evaluated in an exploratory analysis. A total of 103 patients with active CLE (CLASI activity score ≥4) were included. Patients were randomized (3:1) to receive HCQ or placebo in the 16-week double-blind period, and all patients were given HCQ in the following 36-week single-blind period...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27992691/a-multi-biomarker-disease-activity-score-and-the-choice-of-second-line-therapy-in-early-rheumatoid-arthritis-after-methotrexate-failure
#14
Karen Hambardzumyan, Saedis Saevarsdottir, Kristina Forslind, Ingemar F Petersson, Johan K Wallman, Sofia Ernestam, Rebecca J Bolce, Ronald F van Vollenhoven
OBJECTIVE: We investigated whether the multi-biomarker disease activity (MBDA) score predicts optimal add-on treatment in methotrexate-inadequate-responders (MTX-IR) in early rheumatoid arthritis (RA). METHODS: We analysed 157 MTX-IRs (28-joint disease activity score based on erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Farmacotherapy (SWEFOT) trial who were randomized to triple therapy (TT [MTX+sulfasalazine+hydroxychloroquine]) versus MTX+infliximab...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27989589/efficacy-of-triple-association-methotrexate-sulfasalazine-and-hydroxychloroquine-in-early-treatment-of-rheumatoid-arthritis-with-insufficient-response-to-methotrexate-meta-analysis-of-randomized-controlled-trials
#15
Arnaud Mazouyès, Marine Clay, Anne-Catherine Bernard, Philippe Gaudin, Athan Baillet
OBJECTIVES: To evaluate the efficacy of the triple synthetic Disease Modifying Anti-Rheumatic Drugs (sDMARD) combination methotrexate, sulfasalazine and hydroxychloroquine versus a biologic DMARD (bDMARD) in the treatment of early rheumatoid arthritis. METHODS: A systematic literature search was performed using the PubMed and Cochrane databases, and abstracts presented at rheumatology scientific meetings until December 2013. Randomized controlled trials comparing the efficacy and the safety of biologic DMARD with the triple combination were included...
December 15, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27988437/sj%C3%A3-gren-s-syndrome-associated-myositis-with-germinal-centre-like-structures
#16
REVIEW
Alexandra Espitia-Thibault, Agathe Masseau, Antoine Néel, Olivier Espitia, Claire Toquet, Jean-Marie Mussini, Mohamed Hamidou
OBJECTIVE: Muscular impairment is a rare systemic manifestation of SS that is rarely described in the literature and classically non-specific, both clinically and histologically. We reviewed the cases of 4 patients with primary SS presenting with myositis and a common histologic pattern on muscular biopsy with germinal centre-like structures resembling that which occurs in salivary glands. METHODS: We analysed the data files of patients with SS who had muscular manifestations and underwent a muscular biopsy...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27988436/a-scoping-review-of-the-use-of-non-biologic-disease-modifying-anti-rheumatic-drugs-in-the-management-of-large-vessel-vasculitis
#17
REVIEW
Durga Prasanna Misra, Aman Sharma, Tamilarasu Kadhiravan, Vir Singh Negi
Takayasu's arteritis (TA) and Giant cell arteritis (GCA) comprise the large vessel vasculitides (LVV). Patients with LVV are treated with disease-modifying anti-rheumatic drugs (DMARDs), both conventional (cDMARDs) and biologic (bDMARDs). We undertook a scoping review to assess the effectiveness of cDMARDs in TA and GCA. We could identify 11 studies in TA and 18 studies in GCA. There were only 3 randomized controlled trials on methotrexate, one on hydroxychloroquine and two on cyclosporine in GCA, the others being case series (including all studies on TA)...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27982024/epstein-barr-virus-positive-follicular-lymphoma
#18
Nicholas Mackrides, German Campuzano-Zuluaga, Yvan Maque-Acosta, Adrienne Moul, Nouf Hijazi, Francis Offiong Ikpatt, Ronald Levy, Ramiro E Verdun, Kranthi Kunkalla, Yasodha Natkunam, Izidore S Lossos, Francisco Vega, Jennifer Chapman
Epstein-Barr virus (EBV) -associated follicular lymphoma is only rarely reported. Herein, we report the largest series analyzing prevalence and clinicopathologic characteristics of EBV-associated follicular lymphoma occurring in unselected cases. Out of 382 analyzed cases, 10 EBV-positive follicular lymphomas were identified (prevalence=2.6%, 95% confidence interval 1.3-4.0%). All EBV-positive follicular lymphomas showed EBV-encoded small RNA-positive lymphoma cells present in a follicular distribution. Of these, eight also had tissue available for testing of expression of latent membrane protein 1 (LMP1), out of which six (75%) were positive...
December 16, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27974963/bullous-systemic-lupus-erythematosus-and-lupus-nephritis-in-a-young-girl
#19
Tooba Momen, Yahya Madihi
Bullous systemic lupus erythematosus (BSLE) is an autoimmune blistering disease occurring in patients with systemic lupus erythematosus (SLE). It is a rare disease, especially in children. A 14-year-old girl initially presented with fatigue, generalized vesiculobullous skin lesions, and ulcers over the hard palate and oral mucosa. Clinical investigations revealed hematuria and proteinuria, a high erythrocyte sedimentation rate and titer of antinuclear antibody, and anti-double-stranded DNA. Skin biopsy findings were suggestive of BSLE...
November 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27974097/in-early-inflammatory-polyarthritis-more-intensive-management-according-to-2010-acr-eular-criteria-leads-to-higher-rates-of-clinical-remission-comparison-of-two-cohorts-treated-according-to-different-treat-to-target-protocols
#20
Silvia Balduzzi, Carlo Alberto Scirè, Garifallia Sakellariou, Francesca Benaglio, Serena Bugatti, Carlomaurizio Montecucco, Roberto Caporali
OBJECTIVES: The aim of this study was to compare the 12-month probability of remission in early inflammatory arthritis with a milder treatment based on the 1987 criteria or a more intensive protocol based on the 2010 criteria. METHODS: Patients with rheumatoid arthritis (RA) or undifferentiated arthritis (UA) (2005-2012) were included. Before October 2010, patients fulfilling the 1987 criteria received methotrexate (MTX) and possibly low-dose prednisone, while UA hydroxychloroquine (HCQ) (1987-driven cohort)...
December 13, 2016: Clinical and Experimental Rheumatology
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