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https://www.readbyqxmd.com/read/29662765/a-wearable-exoskeleton-suit-for-motion-assistance-to-paralysed-patients
#1
Bing Chen, Chun-Hao Zhong, Xuan Zhao, Hao Ma, Xiao Guan, Xi Li, Feng-Yan Liang, Jack Chun Yiu Cheng, Ling Qin, Sheung-Wai Law, Wei-Hsin Liao
Background/Objective: The number of patients paralysed due to stroke, spinal cord injury, or other related diseases is increasing. In order to improve the physical and mental health of these patients, robotic devices that can help them to regain the mobility to stand and walk are highly desirable. The aim of this study is to develop a wearable exoskeleton suit to help paralysed patients regain the ability to stand up/sit down (STS) and walk. Methods: A lower extremity exoskeleton named CUHK-EXO was developed with considerations of ergonomics, user-friendly interface, safety, and comfort...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29660947/effects-of-walkbot-gait-training-on-kinematics-kinetics-and-clinical-gait-function-in-paraplegia-and-quadriplegia
#2
Jongseok Hwang, Yongil Shin, Ji-Ho Park, Young Joo Cha, Joshua Sung H You
BACKGROUND: The robotic-assisted gait training (RAGT) system has gained recognition as an innovative, effective paradigm to improve functional ambulation and activities of daily living in spinal cord injury and stroke. However, the effects of the Walkbot robotic-assisted gait training system with a specialized hip-knee-ankle actuator have never been examined in the paraplegia and quadriplegia population. OBJECTIVE: The aim of this study was to determine the long-term effects of Walkbot training on clinical for hips and knee stiffness in individuals with paraplegia or quadriplegia...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29652785/clinical-prediction-rule-for-heterotopic-ossification-of-the-hip-in-patients-with-spinal-cord-injury
#3
Eduardo M Suero, Mustafa Citak
STUDY DESIGN: Case-control study; clinical prediction rule. OBJECTIVE: To construct and internally validate a clinical prediction rule to identify patients at high risk of developing heterotopic ossification (HO) after spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: HO after SCI can lead to loss of joint mobility, loss of function, peripheral nerve entrapment, and pressure sores. HO is usually diagnosed based on clinical symptoms, as no laboratory tests are yet available to identify patients with early HO formation...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29652237/failure-of-facet-replacement-system-with-metal-on-metal-bearing-surface-and-subsequent-discovery-of-cobalt-allergy-report-of-2-cases
#4
Matthew L Goodwin, William Ryan Spiker, Darrel S Brodke, Brandon D Lawrence
The aim of this study was to report on 2 patients in whom metal-on-metal (MOM) facet replacements failed, with subsequent positive findings on allergy testing. Motion-preserving devices have been used with limited success when instrumentation is indicated in the mobile spine. MOM-bearing surfaces in orthopedics were developed to increase implant longevity, yet have been associated with numerous adverse outcomes, including local tissue reactions, pseudotumors, metallosis, and the need for revision surgery. Five patients with spinal stenosis and low-grade spondylolisthesis were randomized to undergo facet replacement surgery with the ACADIA facet replacement system at the authors' institution...
April 13, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29642901/profile-of-osteopathic-practice-in-spain-results-from-a-standardized-data-collection-study
#5
Gerard Alvarez Bustins, Pedro-Victor López Plaza, Sonia Roura Carvajal
BACKGROUND: There is limited research regarding patients' profiles and consumer attitudes and habits of osteopathy in Spain. The purpose of this study was to profile patients who regularly receive osteopathic care in Spain using an internationally developed standardized data collection tool. METHOD: During the period between April 2014 and December 2015, a UK-developed standardized data collection tool was distributed to Spanish osteopaths who voluntarily agreed to participate in this cross-sectional study...
April 11, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29628589/clonidine-as-an-adjuvant-to-caudal-epidural-ropivacaine-for-lumbosacral-spine-surgeries
#6
Saraswathi Nagappa, Sandhya Kalappa, Raghavendra Biligiri Sridhara
Background: Caudal epidural analgesia is a proven technique for providing analgesia for spinal surgeries. Prolonged pain relief with no motor blockade is desired for early mobilization. Objective: The objective of this study is to compare the effect of adding 1 μg/kg of clonidine to injection ropivacaine 0.2% with respect to duration of analgesia, hemodynamic effects, and associated side effects. Methodology: In this prospective double-blind study, a total of 60 patients undergoing lumbosacral spine surgery were randomized to receive 25 cc caudal epidural injection of either injection ropivacaine 0...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628559/comparison-of-postoperative-analgesic-efficacy-of-wound-site-infiltration-and-ultrasound-guided-transversus-abdominis-plane-block-with-0-5-ropivacaine-in-lower-abdominal-surgeries-under-spinal-anesthesia
#7
N Pratheeba, R Remadevi, I Joseph Raajesh, V Bhavani, D K Tripathy, R Ravindra Bhat
Context: Optimization and providing excellent quality of postoperative analgesia after total abdominal hysterectomy is a determinant factor of better clinical outcome, increases patient satisfaction, and allows early mobilization of the patient. Aims: The aim of this study is to compare the postoperative analgesic efficacy of wound site infiltration (WSI) and ultrasound-guided transversus abdominis plane block (TAPB) with 0.5% ropivacaine in lower abdominal surgeries under spinal anesthesia...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29619249/participation-restriction-and-assistance-needs-in-people-with-spinal-cord-injuries-of-more-than-40-year-duration
#8
Gordana Savic, Hans L Frankel, Mohamed Ali Jamous, Bakulesh M Soni, Susan Charlifue
Study design: Prospective observational. Objectives: Examine changes in participation restriction and assistance needs in a sample of people with long-standing spinal cord injuries (SCIs). Setting: Two British spinal centres. Methods: The sample consisted of British ageing with SCI study participants who were seen at baseline (1990 or 1993) and in the final follow-up (2010). Outcome measures were the Craig Handicap Assessment and Reporting Technique-Short Form (CHART-SF) and interview questions about assistance needs...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29610008/surgical-outcomes-of-spinal-cord-and-cauda-equina-ependymoma-postoperative-motor-status-and-recurrence-for-each-who-grade-in-a-multicenter-study
#9
Kazuyoshi Kobayashi, Kei Ando, Fumihiko Kato, Tokumi Kanemura, Koji Sato, Mitsuhiro Kamiya, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
BACKGROUND: The goals of the study are to analyze postoperative outcomes and recurrence in cases of spinal cord and cauda equina ependymoma in each World Health Organization (WHO) Grade, and to examine the influence of extent of surgical removal on prognosis. Spinal ependymoma has a relatively high frequency among intramedullary spinal cord tumors. The tumor is classified in WHO guidelines as grades I, II, and III, but few studies have examined postoperative prognosis based on these grades...
March 30, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29609565/the-clinical-relevance-of-the-presence-of-bridging-syndesmophytes-on-kyphosis-correction-and-maintenance-following-pedicle-subtraction-osteotomy-for-thoracolumbar-kyphotic-deformity-in-ankylosing-spondylitis-a-comparative-cohort-study
#10
Sai-Hu Mao, Zong-Xian Feng, Bang-Ping Qian, Yong Qiu
BACKGROUND: The presence of bridging syndesmophytes (BS) in spinal osteotomy region serves traditionally as one critical determinant for selection of osteotomy techniques. While nowadays the proportion of kyphotic ankylosing spondylitis (AS) patients receiving pedicle subtraction osteotomy (PSO) with yet mobile neighboring disc has seen a substantial increase. Literatures investigating the clinical relevance of the presence of BS on kyphosis correction and maintenance following PSO are scarce...
April 2, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29608900/sensitivity-of-the-sci-fi-at-in-individuals-with-traumatic-spinal-cord-injury
#11
Tamra Keeney, Mary Slavin, Pamela Kisala, Pengsheng Ni, Allen W Heinemann, Susan Charlifue, Denise C Fyffe, Ralph J Marino, Leslie R Morse, Lynn A Worobey, Denise Tate, David Rosenblum, Ross Zafonte, David Tulsky, Alan M Jette
OBJECTIVE: To examine the ability of the Spinal Cord Injury Functional Index Assistive Technology (SCI-FI/AT) measure to detect change in persons with SCI. DESIGN: Multi-site, longitudinal (12-month follow-up). SETTING: 9 SCI Model Systems programs. PARTICIPANTS: 165 adults with SCI enrolled in the SCI Model Systems database. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: SCI-FI/AT CAT (Basic Mobility, Self-Care, Fine Motor Function, Wheelchair Mobility, and/or Ambulation) completed at discharge from rehabilitation and 12 months post-SCI...
March 30, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29604317/therapeutic-time-window-of-anti-high-mobility-group-box-1-antibody-administration-in-mouse-model-of-spinal-cord-injury
#12
Masahide Nakajo, Naohiro Uezono, Hideyuki Nakashima, Hidenori Wake, Setsuro Komiya, Masahiro Nishibori, Kinichi Nakashima
Spinal cord injury (SCI) is a devastating neurologic disorder that often leads to permanent disability, and there is no effective treatment for it. High mobility group box-1 (HMGB1) is a damage-associated molecular protein that triggers sterile inflammation upon injuries. We have previously shown that two administrations of neutralizing monoclonal antibody (mAb) against HMGB1 (immediately after (0 hours) and 6 hours after) SCI dramatically improves functional recovery after SCI in mice. However, when considering clinical application, 0 hours after SCI is not practical...
March 28, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29600213/rotatory-subluxation-and-facet-deformity-in-the-atlanto-occipital-joint-in-patients-with-chronic-atlantoaxial-rotatory-fixation-two-case-reports
#13
Masafumi Kashii, Kenta Masuhara, Takashi Kaito, Motoki Iwasaki
Introduction: The relationship between the morphometry of atlantoaxial joint and chronic atlantoaxial rotatory fixation (AARF) is well known, but disorders in the atlanto-occipital joint in chronic AARF are not fully elucidated. The authors report two rare cases of secondary deformities in the atlanto-occipital joint in chronic AARF. Case Reports: Two patients with chronic AARF were treated with closed manipulation, skull traction and halo-vest immobilization. Clinical outcomes and radiographs were reviewed retrospectively, focusing on pathological changes in the atlanto-occipital joint using multiplanar reconstruction computed tomography and three-dimensional computed tomography images...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29587655/impedance-cardiography-as-tool-for-continuous-hemodynamic-monitoring-during-cesarean-section-randomized-prospective-double-blind-study
#14
Alessandro D'Ambrosio, Antonella Cotoia, Renata Beck, Potito Salatto, Lada Zibar, Gilda Cinnella
BACKGROUND: Impedance Cardiography (ICG) is a non-invasive tool for continuous hemodynamic monitoring. Aims of our study were to assess the utility of ICG to evaluate the hemodynamic impact of 6 mg (GL6) vs 8 mg (GL8) levobupivacaine combined with fentanyl in healthy patients undergoing elective cesarean section; secondary, to compare the duration and quality of analgesia and anesthesia. METHODS: Sixty-two women receiving combined spinal-epidural (CSE) for elective cesarean delivery were randomly allocated to GL6 or GL8 groups...
March 27, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29581519/internet-delivered-mindfulness-for-people-with-depression-and-chronic-pain-following-spinal-cord-injury-a-randomized-controlled-feasibility-trial
#15
Jasmine Heath Hearn, Katherine Anne Finlay
STUDY DESIGN: Between-subjects, randomized controlled feasibility study. OBJECTIVES: Populations with reduced sensory and motor function are at increased risk of depression, anxiety and pain, and may be less geographically mobile. This study explored the efficacy and feasibility of web-based mindfulness training for people with spinal cord injury (SCI). SETTING: UK community sample. METHODS: Participants were randomly allocated to an 8-week online mindfulness intervention (N = 36), or to internet-delivered psychoeducation (N = 31)...
March 26, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29581017/transforaminal-endoscopic-decompression-for-lumbar-spinal-stenosis-a-novel-surgical-technique-and-clinical-outcomes
#16
Sang-Ha Shin, Jun-Seok Bae, Sang-Ho Lee, Han-Joong Keum, Ho-Jin Kim, Won-Seok Jang
OBJECTIVE: Transforaminal endoscopic treatment has been reported to be an effective treatment option in patients with lumbar disc herniation. However, it is rarely performed for spinal stenosis because of the limitation of endoscopic working mobility due to the exiting nerve root and foraminous bony structure. The objective of the present study was to describe a novel transforaminal endoscopic decompression technique for spinal stenosis and report the clinical results. METHODS: From October 2015 to October 2016, 30 consecutive cases were diagnosed as lateral recess stenosis in our institution and underwent transforaminal endoscopic decompression...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29577882/tpc2-mediated-ca-2-signaling-is-required-for-the-establishment-of-synchronized-activity-in-developing-zebrafish-primary-motor-neurons
#17
Jeffrey J Kelu, Sarah E Webb, Antony Galione, Andrew L Miller
During the development of the early spinal circuitry in zebrafish, spontaneous Ca2+ transients in the primary motor neurons (PMNs) are reported to transform from being slow and uncorrelated, to being rapid, synchronized and patterned. In this study, we demonstrated that in intact zebrafish, Ca2+ release +via two-pore channel type 2 (TPC2) from acidic stores/endolysosomes is required for the establishment of synchronized activity in the PMNs. Using the SAIGFF213A;UAS:GCaMP7a double-transgenic zebrafish line, Ca2+ transients were visualized in the caudal PMNs (CaPs)...
March 22, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29573263/effect-of-pre-operative-methylprednisolone-on-orthostatic-hypotension-during-early-mobilization-after-total-hip-arthroplasty
#18
V Lindberg-Larsen, P B Petersen, Ø Jans, T Beck, H Kehlet
BACKGROUND: Orthostatic hypotension (OH) and intolerance (OI) are common after total hip arthroplasty (THA) and may delay early mobilization. The pathology of OH and OI includes a dysregulated post-operative vasopressor response, by a hitherto unknown mechanism. We hypothesized that OI could be related to the inflammatory stress response which is inhibited by steroid administration. Consequently, this study evaluated the effect of a pre-operative high-dose methylprednisolone on OH and OI early after THA...
March 24, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29564476/population-based-study-of-age-and-sex-related-differences-in-muscle-density-and-size-in-thoracic-and-lumbar-spine-the-framingham-study
#19
F Johannesdottir, B Allaire, D E Anderson, E J Samelson, D P Kiel, M L Bouxsein
Relative age-related deficit in trunk muscle density was greater in women than men whereas the relative decrease in muscle mass with age was similar in both sexes. The greater muscle fat content and greater age-related fat accumulation among women may contribute to women suffering more functional disabilities than men. INTRODUCTION: A better understanding of the effect of aging on trunk musculature will have implications for physical function, disability, pain, and risk of injury in older adults...
March 22, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29558941/perturbing-chondroitin-sulfate-proteoglycan-signaling-through-lar-and-ptp%C3%AF-receptors-promotes-a-beneficial-inflammatory-response-following-spinal-cord-injury
#20
Scott Dyck, Hardeep Kataria, Arsalan Alizadeh, Kallivalappil T Santhosh, Bradley Lang, Jerry Silver, Soheila Karimi-Abdolrezaee
BACKGROUND: Traumatic spinal cord injury (SCI) results in upregulation of chondroitin sulfate proteoglycans (CSPGs) by reactive glia that impedes repair and regeneration in the spinal cord. Degradation of CSPGs is known to be beneficial in promoting endogenous repair mechanisms including axonal sprouting/regeneration, oligodendrocyte replacement, and remyelination, and is associated with improvements in functional outcomes after SCI. Recent evidence suggests that CSPGs may regulate secondary injury mechanisms by modulating neuroinflammation after SCI...
March 20, 2018: Journal of Neuroinflammation
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