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https://www.readbyqxmd.com/read/29451451/critical-assessment-of-pediatric-neurosurgery-patient-parent-educational-information-obtained-via-the-internet
#1
Michael Garcia, Christopher Daugherty, Bertha Ben Khallouq, Todd Maugans
OBJECTIVE The Internet is used frequently by patients and family members to acquire information about pediatric neurosurgical conditions. The sources, nature, accuracy, and usefulness of this information have not been examined recently. The authors analyzed the results from searches of 10 common pediatric neurosurgical terms using a novel scoring test to assess the value of the educational information obtained. METHODS Google and Bing searches were performed for 10 common pediatric neurosurgical topics (concussion, craniosynostosis, hydrocephalus, pediatric brain tumor, pediatric Chiari malformation, pediatric epilepsy surgery, pediatric neurosurgery, plagiocephaly, spina bifida, and tethered spinal cord)...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29449504/response-to-tumor-necrosis-factor-inhibition-in-male-and-female-patients-with-ankylosing-spondylitis-data-from-a-swiss-cohort
#2
Monika Hebeisen, Regula Neuenschwander, Almut Scherer, Pascale Exer, Ulrich Weber, Giorgio Tamborrini, Raphael Micheroli, Lukas M Wildi, Pascal Zufferey, Michael J Nissen, Peter M Villiger, Jürg Bernhard, Axel Finckh, Irene E van der Horst-Bruinsma, Joachim Sieper, Robert Landewé, Désirée van der Heijde, Adrian Ciurea
OBJECTIVE: To investigate sex differences in connection with the effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with ankylosing spondylitis (AS). METHODS: A total of 440 patients with AS (294 men; 146 women) initiating a first TNFi in the prospective Swiss Clinical Quality Management Cohort were included. We evaluated the proportion of patients achieving the 20% and 40% improvement in the Assessment of Spondyloarthritis international Society criteria (ASAS20 and ASAS40) as well as Ankylosing Spondylitis Disease Activity Score (ASDAS) improvement and status scores at 1 year...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29434463/initial-outcomes-from-a-multicenter-study-utilizing-the-indego-powered-exoskeleton-in-spinal-cord-injury
#3
Candy Tefertiller, Kaitlin Hays, Janell Jones, Arun Jayaraman, Clare Hartigan, Tamara Bushnik, Gail F Forrest
Objective: To assess safety and mobility outcomes utilizing the Indego powered exoskeleton in indoor and outdoor walking conditions with individuals previously diagnosed with a spinal cord injury (SCI). Methods: We conducted a multicenter prospective observational cohort study in outpatient clinics associated with 5 rehabilitation hospitals. A convenience sample of nonambulatory individuals with SCI (N = 32) completed an 8-week training protocol consisting of walking training 3 times per week utilizing the Indego powered exoskeleton in indoor and outdoor conditions...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29433962/does-intrathecal-morphine-in-spinal-anesthesia-have-a-role-in-modern-multimodal-analgesia-for-primary-total-joint-arthroplasty
#4
Jonathan W Cheah, David C Sing, Erik N Hansen, Pedram Aleshi, Thomas P Vail
BACKGROUND: Intrathecal morphine (ITM) combined with bupivacaine spinal anesthesia can improve postoperative pain, but has potential side effects of postoperative nausea/vomiting (PONV) and pruritus. With the use of multimodal analgesia and regional anesthetic techniques, postoperative pain control has improved significantly to a point where ITM may be avoided in total joint arthroplasty (TJA). METHODS: We performed a retrospective study of primary TJA patients who underwent a standardized multimodal recovery pathway and received bupivacaine neuraxial anesthesia with ITM vs bupivacaine neuraxial anesthesia alone (control)...
January 31, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29428926/immediate-changes-after-manual-therapy-in-patients-with-persistent-nonspecific-back-pain-a-randomized-controlled-trial
#5
Gemma Victoria Espí-López, Maria-Arantzazu Ruescas-Nicolau, M Luz Sanchez-Sanchez, Anna Arnal-Gómez, Mercè Balasch-Bernat, Elena Marques-Sule
Context • Thoracic manipulation decreases pain and disability. However, when such manipulation is contraindicated, the use of other manual techniques based on the regional interdependence of the thoracic spine, upper ribs, and shoulders is an alternative approach. Objective • The study intended to investigate the immediate changes resulting from 3 manual therapy treatments on spinal mobility, flexibility, comfort, and pain perception in patients with persistent, nonspecific back pain as well as changes in their sense of physical well-being and their perception of change after treatment...
February 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29428215/spinal-pkc-activation-induced-neuronal-hmgb1-translocation-contributes-to-hyperalgesia-in-a-bone-cancer-pain-model-in-rats
#6
Kang An, Hui Rong, Huadong Ni, Chunyan Zhu, Longsheng Xu, Qianying Liu, Yajing Chen, Ying Zheng, Bing Huang, Ming Yao
Bone cancer pain (BCP) remains a serious complication of malignancy, which is an intractable clinical problem due to the gap in knowledge of its underlying mechanisms. Recent studies have demonstrated that the major involvement of neuroinflammation, particularly high-mobility group box 1 (HMGB1), which was identified as a late mediator of inflammation, in a number of pain conditions. However, the underlying mechanisms and functions of HMGB1 release in spinal cord, and its contributions to the development of BCP as well, are poorly understood...
February 8, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29421543/sigma-1-receptor-mediated-hmgb1-expression-in-spinal-cord-is-involved-in-the-development-of-diabetic-neuropathic-pain
#7
Xiaolei Wang, Chang Feng, Yong Qiao, Xin Zhao
No study has been conducted to examine the interactions of sigma-1 receptor (Sigma-1R) and high mobility group box 1 protein (HMGB1) in the development of diabetic peripheral neuropathy. Thus, we examined the effects of streptozotocin (STZ) treatment on expression of HMGB1 in subcellular levels in the dorsal root ganglion (DRG) in both wild-type and Sigma-1R-/- mice and evaluated the effects of repeated intrathecal administrations of selective Sigma-1R antagonists BD1047, agonist PRE-084, or HMGB1 inhibitor glycyrrhizin on peripheral neuropathy in wild-type mice...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29417050/d-amino-acid-oxidase-plg72-interaction-and-d-serine-modulation
#8
REVIEW
Loredano Pollegioni, Luciano Piubelli, Gianluca Molla, Elena Rosini
pLG72 is a small, primate-specific protein of 153 amino acids. It is the product of the G72 gene, expressed in testis, spinal cord, and brain. The presence of G72 transcript and pLG72 has recurrently been called into question, however G72 mRNA and pLG72 protein levels were higher in blood and brain of patients with schizophrenia than in healthy controls. On the one hand, the SNP rs2391191 corresponding to the R30K substitution in pLG72 was genetically linked to schizophrenia, reduced thickness of the brain cortex in schizophrenia-affected individuals, and altered memory function...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29415765/double-non-contiguous-fractures-in-a-patient-with-spondylo-epiphyseal-dysplasia-with-spinal-ankylosis-treated-with-open-and-percutaneous-spinal-fixation-technique-a-case-report
#9
Takahiro Ushijima, Kenichi Kawaguchi, Tadashi Matsumoto, Masaki Takagi, Tatsuro Kondoh, Gen Nishimura, Aritoshi Iida, Shiro Ikegawa, Nobuhiko Haga, Go Kato
BACKGROUND: Patients with ankylosing spines are susceptible to developing spinal fractures even with minor trauma and can develop early or late neurological injuries. These fractures require early and aggressive surgical management to enable spinal stability and/or neural decompression. Being highly unstable by nature, they require relatively long segment instrumentation and fusion, which can increase paravertebral soft tissue damage and perioperative bleeding. The purpose of this report is to describe a rare case of traumatic double fractures at the cervico-thoracic and thoraco-lumbar transition zones in ankylosing spine with spondylo-epiphyseal dysplasia (SED) of unknown cause, which were successfully treated with a combined open and percutaneous spinal fusion procedure...
February 7, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29415014/buttock-tissue-response-to-loading-in-men-with-spinal-cord-injury
#10
Sharon Eve Sonenblum, Stephen H Sprigle
OBJECTIVE/BACKGROUND: Despite the fact that most people with a spinal cord injury who use a wheelchair for mobility are considered at-risk for pressure ulcer (PrU) development, there still exists a spectrum of risk amongst this group. Efforts to differentiate risk level would benefit from clinical tools that can measure or predict the buttocks response to loading. Therefore, the goal of this study was to identify how tissue compliance and blood flow were impacted by clinically-measurable risk factors in young men with SCI...
2018: PloS One
https://www.readbyqxmd.com/read/29399749/should-the-macular-lesions-around-spinal-dysraphism-be-excised-analysis-of-macular-lesions-accompanying-spinal-dysraphism
#11
Necmettin Tutuncu, Goktekin Tenekeci, Sakir Unal, Necat Yilmaz, Celal Bagdatoglu
AIM: Whether the macular lesions associated with spinal dysraphism should be preserved is controversial. This area is usually excised during reconstruction. This study aims to characterize the macular lesions associated with spinal dysraphism and to determine the outcomes of cases in which macular lesions are not excised. MATERIAL AND METHODS: The patient cohort comprised 17 patients with spinal dysraphism who were treated at Mersin University Hospital from 2005 through 2007...
December 17, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29393688/systematic-review-of-high-level-mobility-training-in-people-with-a-neurological-impairment
#12
Tanja Spencer, Sara Aldous, Gavin Williams, Michael Fahey
AIM: The objective of this paper was to systematically review the efficacy of interventions targeting high-level mobility skills in people with a neurological impairment. METHODS: A comprehensive electronic database search was conducted. Study designs were graded using the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) system and methodological quality was described using the Physiotherapy Evidence Database (PEDro) scale. RESULTS: Twelve exploratory studies (AACPDM levels IV/V), of limited methodological quality (PEDro scores of 2-3 out of 10), were included...
February 2, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29392099/improving-c1-c2-complex-fusion-rates-an-alternate-approach
#13
REVIEW
Samer S Ghostine, Paul E Kaloostian, Christ Ordookhanian, Sean Kaloostian, Parham Zarrini, Terrence Kim, Stephen Scibelli, Scott J Clark-Schoeb, Srinath Samudrala, Carl Lauryssen, Amandip S Gill, Patrick J Johnson
The surgical repair of atlantoaxial instabilities (AAI) presents complex and unique challenges, originating from abnormalities and/or trauma within the junction regions of the C1-C2 atlas-axis, to surgeons. When this region is destabilized, surgical fusion becomes of key importance in order to prevent spinal cord injury. Several techniques can be utilized to provide for the adequate fusion of the atlantoaxial construct. Nevertheless, many individuals have less than ideal rates of fusion, below 35%-40%, which also involves the C2 nerve root being sacrificed...
November 29, 2017: Curēus
https://www.readbyqxmd.com/read/29388089/intraosseous-pseudomeningocele-of-the-mobile-spine-a-case-report-and-review-of-the-literature
#14
Emily Rider-Longmaid, Junjian Huang, Ronnie Sebro, Harvey Smith
BACKGROUND: Pseudomeningoceles most commonly occur due to prior trauma or surgery and are often located in the posterior paraspinous tissues. Here, we report a case of an intraosseous pseudomeningocele that mimicked an intra-osseous T2 hyperintense lesion in the L1 vertebral body. CASE DESCRIPTION: A 64-year-old male presented with back, left lateral thigh and left knee pain lasting several months. He had no prior history of trauma or surgery. Radiographs of the lumbar spine showed mild levoscoliotic curvature of the lumbar spine, Baastrup's changes between the spinous processes, multilevel degenerative disc disease and facet arthropathy...
January 31, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29377253/how-to-explore-fetal-sacral-agenesis-without-open-dysraphism-key-prenatal-imaging-and-clinical-implications
#15
Nicolas Mottet, Yann Chaussy, Frederic Auber, Fabien Guimiot, Francine Arbez-Gindre, Didier Riethmuller, Célia Cretolle, Alexandra Benachi
The estimated prevalence of fetal caudal dysgenesis is 1 per 100,000 births. The functional prognosis of sacral agenesis is dominated by the large spectrum of associated caudal malformations. Except for cases associated with hydrocephalus secondary to open spinal dysraphism or chromosomal anomalies, association with mental deficiency is rare. We propose a systematic prenatal approach to cases of fetal sacral agenesis based on 9 etiologic items: clinical context, type of sacral dysgenesis, associated spinal cord malformations, mobility of lower limbs, investigation of the presacral region, analysis of the gastrointestinal tract, analysis of the genitourinary tract, associated vertebral defects, and cytogenetic analysis...
January 27, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29373733/functional-relevance-of-radiographic-spinal-progression-in-axial-spondyloarthritis-results-from-the-german-spondyloarthritis-inception-cohort
#16
Denis Poddubnyy, Joachim Listing, Hildrun Haibel, Sven Knüppel, Martin Rudwaleit, Joachim Sieper
Objectives: The aim of the study was to investigate the functional relevance of the development of structural damage in the spine in patients with early axial spondyloarthritis (axSpA). Methods: Altogether, 210 patients with early axSpA (symptom duration ⩽10 years) who completed a 2-year clinical and radiographic follow-up in the GErman SPondyloarthritis Inception Cohort were included. An association between structural damage in the spine [modified Stoke AS Spine Score (mSASSS)] and functional status (the BASFI) or spinal mobility (the BASMI) was assessed in a longitudinal linear mixed model analysis; both unstandardized (β) and standardized (β stand ) regression coefficients were calculated...
January 24, 2018: Rheumatology
https://www.readbyqxmd.com/read/29371701/interventions-for-pressure-ulcers-a-summary-of-evidence-for-prevention-and-treatment
#17
REVIEW
Ross A Atkinson, Nicky A Cullum
STUDY DESIGN: Narrative review. OBJECTIVES: Pressure ulcers are a common complication in people with reduced sensation and limited mobility, occurring frequently in those who have sustained spinal cord injury. This narrative review summarises the evidence relating to interventions for the prevention and treatment of pressure ulcers, in particular from Cochrane systematic reviews. It also aims to highlight the degree to which people with spinal cord injury have been included as participants in randomised controlled trials included in Cochrane reviews of such interventions...
January 25, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29369203/bilateral-decompression-and-intervertebral-fusion-via-unilateral-fenestration-for-complex-lumbar-spinal-stenosis-with-a-mobile-microendoscopic-technique
#18
Baoshan Xu, Haiwei Xu, Xinlong Ma, Yue Liu, Qiang Yang, Hongfeng Jiang, Ning Li, Ning Ji
For complex lumbar spinal stenosis, using of endoscopy technique may provide clear vision with less invasive dissection of paravertebral muscle. The objective of this study was to evaluate the feasibility and clinical efficacy of bilateral decompression and intervertebral fusion via unilateral fenestration for complex lumbar spinal stenosis using mobile microendoscopic discectomy (MMED) technique.A total of 61 patients with complex lumbar spinal stenosis (lumbar canal stenosis combined with degenerative spondylolisthesis, instability, and scoliosis) were treated with this procedure...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29360000/ambulation-and-physical-function-after-eccentric-resistance-training-in-adults-with-incomplete-spinal-cord-injury-a-feasibility-study
#19
Whitley J Stone, Sandra L Stevens, Dana K Fuller, Jennifer L Caputo
BACKGROUND: Strengthening the lower extremities has shown to positively influence walking mechanics in those with neurological deficiencies. Eccentric resistance training (ERT) is a potent stimulus for the development of muscular strength with low metabolic demand. Thereby, ERT may benefit those with incomplete spinal cord injuries (iSCI) seeking to improve ambulatory capacity. DESIGN: This study was aimed to determine the effect of ERT on walking speed, mobility, independence, and at home function following iSCI...
January 23, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29350639/dynamic-mri-in-the-evaluation-of-the-spine-state-of-the-art
#20
Giulia Michelini, Antonella Corridore, Silvia Torlone, Federico Bruno, Claudia Marsecano, Raffaella Capasso, Ferdinando Caranci, Antonio Barile, Carlo Masciocchi, Alessandra Splendiani
INTRODUCTION: Degenerative disease of the spine is a generic term encompassing a wide range of different disease processes, which leads to spinal instability; traumatic/neoplastic events can accelerate this aging process. Therefore, the dynamic nature of the spine and its mobility across multiple segments is difficult to depict with any single imaging modality. METHODS: A review of PubMed databases for articles published about kMRI in patients with cervical and lumbar spinal desease was performed...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
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