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Spinal mobility

Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun He
High mobility group box-1 (HMGB1) could function as an early trigger for pro-inflammatory activation following spinal cord injury (SCI). Spinal cord edema contributes to inflammatory response mechanisms and a poor clinical prognosis following SCI, for which efficient therapies targeting the specific molecules involved remain limited. This study was designed to evaluate the roles of HMGB1 on the regulation of early spinal cord edema, astrocyte activation and aquaporin-4 (AQP4) expression in a rat SCI model. Adult female Sprague-Dawley rats were subjected to laminectomy at T10, and the SCI model was induced by a heavy falling object...
June 21, 2018: Journal of Neurotrauma
Bruna Dos Santos Ramalho, Fernanda Martins de Almeida, Conrado Mendonça Sales, Silmara de Lima, Ana Maria Blanco Martinez
In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury (SCI) are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells (MSCs) in a compressive SCI model...
June 2018: Neural Regeneration Research
Megan Richards, Hussein Al-Youssef, Jung-Kyong Kim, Stéphane Poitras, John Penning, Paul E Beaulé
BACKGROUND: Outpatient hip arthroplasty is being performed more routinely; however, safety remains a concern. The purpose of this study was to compare the rate of adverse events of outpatient total hip arthroplasty (THA) and assess barriers to discharge. METHODS: We examined 136 patients who underwent unilateral THA by one surgeon and were discharged on the same day of surgery. Using propensity matching, 136 inpatients who received the same procedure, and were discharged on postoperative day one or later, were identified...
May 31, 2018: Journal of Arthroplasty
Samantha J Prosser, Adrian G Barnett, Yvette D Miller
BACKGROUND: In response to rising rates of medical intervention in birth, there has been increased international interest in promoting normal birth (without induction of labour, epidural/spinal/general anaesthesia, episiotomy, forceps/vacuum, or caesarean section). However, there is limited evidence for how best to achieve increased rates of normal birth. In this study we examined the role of modifiable and non-modifiable factors in experiencing a normal birth using retrospective, self-reported data...
June 18, 2018: BMC Pregnancy and Childbirth
Fatin Affas, Carl-Olav Stiller, Eva-Britt Nygårds, Niclas Stephanson, Per Wretenberg, Christina Olofsson
Pain after total knee arthroplasty (TKA) is difficult to control. A recently developed and increasingly popular method for postoperative analgesia following knee and hip arthroplasty is Local Infiltration Analgesia (LIA) with ropivacaine, ketorolac and epinephrine. This method is considered to have certain advantages, which include administration at the site of traumatized tissue, minimal systemic side effects, faster postoperative mobilization, earlier postoperative discharge from hospital and less opioid consumption...
December 29, 2017: Scandinavian Journal of Pain
N M Agalave, S AbdelMoaty, P Lundback, U Andersson, H Harris, C I Svensson
Aims Increasing evidence indicates that extracellular high mobility group box-1 protein (HMGB1) is involved in the pathogenesis of inflammatory and autoimmune disease. Data from our laboratory demonstrates that HMGB1 contributes to nociceptive behavior in a model of rheumatoid arthritis-induced pain. HMGB1 binds to multiple receptors, including toll like receptor (TLR) 2, TLR4 and receptor for advanced glycation end products (RAGE). When the cysteine in position C106 is in the reduced thiol form and C23 and C45 are engaged in a disulfide bridge (disulfide HMGB1), the molecule functions as a cytokine-inducing TLR4 ligand...
December 29, 2017: Scandinavian Journal of Pain
Andrew Ekelem, Michael Goldfarb
Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, although most exoskeleton technologies can accommodate low to moderate spasticity, the presence of moderate to severe spasticity can significantly impair gait kinematics when using an exoskeleton...
2018: Frontiers in Neuroscience
Juan L Garrido-Castro, Rafael Curbelo, Ramón Mazzucchelli, María E Domínguez-González, Cristina Gonzalez-Navas, Bryan J Flores Robles, Pedro Zarco, Juan Mulero, Luis Cea-Calvo, María J Arteaga, Pilar Font-Ugalde, Loreto Carmona, Eduardo Collantes-Estevez
OBJECTIVE: Conventional measures of spinal mobility used in the assessment of patients with axial spondyloarthritis (axSpA), such as the Bath Ankylosing Spondylitis Metrology Index and its components, are subject to interobserver variability. The University of Córdoba Ankylosing Spondylitis Metrology Index (UCOASMI) is a validated composite index based on a motion video-capture system, UCOTrack. Our objective was to assess its reproducibility in clinical practice settings. METHODS: We carried out an observational study of repeated measures in 3 centers...
June 15, 2018: Journal of Rheumatology
Yoshinori Ishii, Hideo Noguchi, Junko Sato, Satoshi Takayama, Yui Okada, Shin-Ichi Toyabe
Background: Venous thromboembolic events (VTE) are a common complication of total knee arthroplasty (TKA). Prior studies have discussed the utility of mechanical VTE prophylaxis as a monotherapy for low-risk TKA patients. We assess the incidence of clinically significant deep venous thrombosis (DVT) or pulmonary embolism (PE) in low-risk TKA patients who receive mechanical VTE prophylaxis and undergo spinal, epidural, or general anesthesia for their surgery. Methods: A retrospective study was performed on consecutive low-risk patients who received a TKA between July 2002 and June 2015 with spinal anesthesia ( n  = 65), epidural and general anesthesia ( n  = 154), or general anesthesia alone ( n  = 152)...
April 2018: Journal of Clinical Orthopaedics and Trauma
Marlene Elmelund, Niels Klarskov, Fin Biering-Sørensen
STUDY DESIGN: Cross-sectional study. OBJECTIVES: There is a knowledge gap on urinary incontinence in women with spinal cord injury. Hence, the aim of this study was to determine the prevalence and conditions associated with urinary incontinence in this population. SETTING: Clinic for Spinal Cord Injuries, Rigshospitalet, Denmark. METHODS: Women with a spinal cord injury between September 1999 and August 2016, who attended a consultation in our clinic during August 2010-August 2016, were included...
June 12, 2018: Spinal Cord
Evan Luther, Timur Urakov, Steven Vanni
BACKGROUND AND STUDY OBJECTIVE:  Complex traumatic lumbar spine fractures are difficult to manage and typically occur in younger patients. Surgical immobilization for unstable fractures is an accepted treatment but can lead to future adjacent-level disease. Furthermore, large variations in fracture morphology create significant difficulties when attempting fixation. Therefore, a surgical approach that considers both long-term outcomes and fracture type is of utmost importance. We present a novel technique for percutaneous fixation without interbody or posterolateral fusion in a young patient with bilateral pedicle dissociations and an acute-onset incomplete neurologic deficit...
June 11, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Maria Meyer, Agustina Lara, Hazel Hunt, Joseph Belanoff, E Ronald de Kloet, Maria Claudia Gonzalez Deniselle, Alejandro F De Nicola
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, suggesting a pathogenic role for glucocorticoids in this disorder. Considering this endocrine background, we examined whether the glucocorticoid receptor (GR) modulator CORT 113176 prevents spinal cord neuropathology of Wobblers...
June 8, 2018: Neuroscience
Karen M Kruger, Christina M R Garman, Joseph J Krzak, Adam Graf, Sahar Hassani, Sergey Tarima, Peter F Sturm, Kim W Hammerberg, Purnendu Gupta, Gerald F Harris
STUDY DESIGN: Prospective. OBJECTIVES: The purpose of this study was to compare gait among patients with scoliosis undergoing posterior spinal fusion and instrumentation (PSFI) to typically developing subjects and determine if the location of the lowest instrumented vertebra impacted results. SUMMARY OF BACKGROUND DATA: PSFI is the standard of care for correcting spine deformities, allowing the preservation of body equilibrium while maintaining as many mobile spinal segments as possible...
July 2018: Spine Deformity
C M Bauer, F M Rast, C Böck, R P Kuster, D Baumgartner
OBJECTIVE: This study investigated the location of the axis of rotation in sagittal plane movement of the spine in a free sitting condition to adjust the kinematics of a mobile seat for a dynamic chair. BACKGROUND: Dynamic office chairs are designed to avoid continuous isometric muscle activity, and to facilitate increased mobility of the back during sitting. However, these chairs incorporate increased upper body movement which could distract office workers from the performance of their tasks...
October 2018: Applied Ergonomics
Sally M Taylor, Elaine O Cheung, Ruichen Sun, Veronika Grote, Anthony Marchlewski, Elizabeth L Addington
OBJECTIVE: Evaluate the use of complementary therapies during rehabilitation for patients with traumatic spinal cord injury (SCI). DESIGN: Secondary analyses were conducted to identify the use and associated outcomes of complementary therapies provided by occupational therapists (OTs) and physical therapists (PTs) during rehabilitation from a public dataset. SETTING: Inpatient rehabilitation. PARTICIPANTS: A public dataset composed of 1376 patients with SCI that were enrolled in a five-year, multi-center investigation, the SCIRehab Project...
June 8, 2018: Journal of Spinal Cord Medicine
Akira Hashiguchi, Tsukasa Kanchiku, Norihiro Nishida, Toshihiko Taguchi
STUDY DESIGN: Biomechanical study. PURPOSE: We examined the dynamic characteristics of different operative procedures using three-dimensional finite-element models. OVERVIEW OF LITERATURE: Cervical laminoplasty is often selected for patients requiring multilevel spinal decompression. Many laminoplasty techniques have been developed and are continually being improved. METHODS: Images were extracted for the two intervertebral joints between C3 and C5 in domestic rabbits...
June 2018: Asian Spine Journal
Norimitsu Wakao, Mikinobu Takeuchi, Daniel K Riew, Atsuhiko Hirasawa, Shiro Imagama, Katsuhisa Kawanami, Toshihiro Matsuo, Kenta Murotani, Masataka Deie
Although patients with osteoporotic delayed vertebral collapse (ODVC) have frequently been treated surgically, the efficacy and limitation of conservative treatment for it have not yet been reported. The purpose of this study was to investigate the effectiveness and limitation of further intensive conservative treatment for patients with ODVC.Patients treated for ODVC from 2011 to 2014 with a follow-up period of more than 1 year were eligible. The fundamental treatment strategy consisted of surgical treatment following intensive conservative treatment with daily teriparatide and rehabilitation for 3 months...
June 2018: Medicine (Baltimore)
Carol C Hasler
Early-onset scoliosis (EOS) describes a wide array of diagnoses and deformities exposed to growth. This potentially life-threatening condition is still 1 of the biggest challenges in pediatric orthopaedics. The enlightenment of Bob Campbell's thoracic insufficiency syndrome concept and the negative impact of the earlier short and straight spine fusion approach on respiratory function and survival have fueled the evolution of EOS care. Despite all the progress made, growth-friendly spine surgery remains to be a burden to patients and caregivers...
July 2018: Journal of Pediatric Orthopedics
Zachary Walston, Luis Hernandez, Dale Yake
BACKGROUND AND PURPOSE: Conservative therapies for complex regional pain syndrome (CRPS) have traditionally focused on exercise and desensitization techniques targeted at the involved extremity. The primary purpose of this case series is to report on the potential benefit of utilizing manual therapy to the lumbar spine in conjunction with traditional conservative care when treating patients with lower extremity CRPS. CASE DESCRIPTION: Two patients with the diagnosis of lower extremity CRPS were treated with manual therapy to the lumbar spine in conjunction with education, exercise, desensitization, and soft tissue techniques for the extremity...
June 6, 2018: Physiotherapy Theory and Practice
Julie M Fritz, Jason A Sharpe, Elizabeth Lane, Doug Santillo, Tom Greene, Gregory Kawchuk
BACKGROUND: Low back pain is a common and costly condition. Spinal manipulative therapy (SMT) is a treatment supported in some guidelines, although most clinical trials examining SMT report small effect sizes. Enhancing the effects of SMT requires an understanding of underlying mechanisms and a systematic approach to leverage understanding of mechanisms to create more effective treatment protocols that are scalable in clinical practice. Prior work has identified effects on spinal stiffness and lumbar multifidus activation as possible mechanisms...
June 4, 2018: Trials
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