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https://www.readbyqxmd.com/read/29062653/ascot-autologous-bone-marrow-stem-cell-use-for-osteoarthritis-of-the-thumb-first-carpometacarpal-joint
#1
Matthew P Murphy, Christina Buckley, Conor Sugrue, Emma Carr, Aine O'Reilly, Shane O'Neill, Sean M Carroll
BACKGROUND: The first carpometacarpal joint (CMCJ) in the hand is a commonly affected joint by osteoarthritis. It causes significant thumb base pain, limiting functional capacity. Microfracturing and application of autologous stem cells has been performed on large joints such as the knee but has never been evaluated for use in the smaller joints in the hand. Our aim was to determine the potential benefit of microfracturing and autologous bone marrow stem cells for treatment of osteoarthritis of the first CMCJ in the hand...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29057891/exhaustive-search-for-epistatic-effects-on-the-human-methylome
#2
Tobias Egli, Vanja Vukojevic, Thierry Sengstag, Martin Jacquot, Rubén Cabezón, David Coynel, Virginie Freytag, Angela Heck, Christian Vogler, Dominique J-F de Quervain, Andreas Papassotiropoulos, Annette Milnik
Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which in concert decrease model stability. An additional source introducing significant uncertainty with regard to the detection of robust epistasis is the biological distance between the genetic variation and the trait under study. Here we studied CpG methylation, a genetically complex molecular trait that is particularly close to genomic variation, and performed an exhaustive search for two-locus epistatic effects on the CpG-methylation signal in two cohorts of healthy young subjects...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29026332/ultrasound-guided-methotrexate-injection-for-de-quervain-disease-of-the-wrist-what-lies-beyond-the-horizon
#3
Abdallah El-Sayed Allam, Doaa Shawky Al-Ashkar, Ahmed A Negm, Basma Aly Eltawab, Wei-Ting Wu, Ke-Vin Chang
De Quervain disease (DQVD) is one of the most common causes of lateral wrist pain and can lead to significant disability. The current case involves a right-handed, middle-aged, female patient with severe lateral wrist pain due to DQVD. Her pain was not responsive to oral non-steroidal anti-inflammatory drugs, rehabilitation, and repeated corticosteroid injections. Because she refused surgical intervention, we performed ultrasound-guided methotrexate injections (four times). After the injections, dramatic pain relief, functional improvement, and reduction of the thickness of the retinaculum and tendons in the first dorsal extensor compartment of the wrist were noted...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28988225/persistent-de-quervain-tenosynovitis-induced-by-somatotropin-treatment
#4
Ozan Volkan Yurdakul, Lütfiye Aytüre, Ebru Yilmaz Yalçinkaya
BACKGROUND: Growth hormone deficiency is a well-known clinical entity that is usually treated with somatotropin (growth hormone). Growth hormone has some frequent side effects such as intracranial hypertension, lymphedema and diabetes mellitus. CASE PRESENTATION: We report the case of a 14-year-old girl with a history of wrist pain and clumsiness. Magnetic resonance imaging revealed de Quervain tenosynovitis. The patient had a history of using growth hormones for 12 months...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28987667/shear-wave-elastography-findings-of-de-quervain-tenosynovitis
#5
Rustu Turkay, Ercan Inci, Banu Aydeniz, Meltem Vural
OBJECTIVE: Our aim was to evaluate the feasibility of using shear wave elastography (SWE) to assess first extensor compartment tendons rigidity and its alterations with tenosynovitis. MATERIALS AND METHODS: We performed B-mode ultrasound and SWE to total number of 80 participants. All participants were evaluated clinically to call the diagnosis of de Quervain tenosynovitis or to rule out the diagnosis. We composed 2 groups. Group 1 included 40 healthy volunteers (33 females and 7 male participants with ages ranging from 24 to 60 years, median age was 37...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28985641/a-genetic-marker-associated-with-de-quervain-s-tenosynovitis
#6
Stuart K Kim, Marwa A Ahmed, Andy L Avins, John P A Ioannidis
De Quervain's tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain's tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls...
November 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28969133/fine-needle-aspiration-of-de-quervain-s-thyroiditis-subacute-granulomatous-thyroiditis-a-cytological-review-of-20-cases
#7
Rachna Lamichaney, Mingma Sherpa, Deepak Das, Chumila Thinley Bhutia, Sabina Laishram
INTRODUCTION: De Quervain's Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesions. AIM: The objective of this study was to reveal the cytological characteristics of DQT. MATERIALS AND METHODS: We retrospectively reviewed the clinical and FNAC findings of 20 cases of DQT to find the most reliable features for a confident cytological diagnosis...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28959741/erratum-for-huber-et-al-the-microtubule-stabilizing-protein-clasp1-associates-with-the-theileria-annulata-schizont-surface-via-its-kinetochore-binding-domain
#8
Sandra Huber, Romina Theiler, Daniel de Quervain, Olga Wiens, Tulin Karagenc, Volker Heussler, Dirk Dobbelaere, Kerry Woods
[This corrects the article DOI: 10.1128/mSphere.00215-17.].
September 2017: MSphere
https://www.readbyqxmd.com/read/28888574/patient-and-disease-specific-factors-associated-with-operative-management-of-de-quervain-tendinopathy
#9
Nikolas H Kazmers, Tiffany C Liu, Joshua A Gordon, David J Bozentka, David R Steinberg, Benjamin L Gray
PURPOSE: It remains unclear which factors, patient- or disease-specific, are associated with electing to undergo operative management for de Quervain tendinopathy. Our null hypothesis was that no patient- or disease-specific factors would be associated with the choice of surgical treatment of de Quervain tendinopathy. METHODS: We performed a retrospective review of consecutive patients diagnosed with de Quervain tendinopathy over 3 years by 1 of 3 fellowship-trained hand surgeons at an urban academic institution...
November 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28875127/synthesis-of-evidence-for-the-treatment-of-intersection-syndrome
#10
REVIEW
Konstantine Balakatounis, Antonios G Angoules, Nikolaos A Angoules, Kalomoira Panagiotopoulou
Intersection syndrome is a rare sports overuse injury occurring through friction at the intersection of the first and second compartment of the forearm. Differential diagnosis must be carefully made, especially from De Quervain tendonsynovitis. Clinical examination provides with the necessary information for diagnosis, still magnetic resonance imaging scans and ultrasonography may assist in diagnosis. Treatment consists mainly of rest, use of a thumb spica splint, analgetic and oral nonsteroidal anti-inflammatory drugs and after 2-3 wk progressive stretching and muscle strengthening...
August 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28867250/extensor-retinaculum-reconstruction-using-the-wide-awake-approach
#11
REVIEW
Takehiko Takagi, Yuka Kobayashi, Masahiko Watanabe
De Quervain tenosynovitis is often treated by simple release of the first compartment. However, patients can suffer from persistent postoperative problems, including "clumsy" use of the thumb, as a result of redislocation or bowstringing of the extensor pollicis brevis/abductor pollicis longus tendons or irritation of the superficial branch of the radial nerve. Here we describe our method for first compartment reconstruction, in which the flaps are sutured after double-flap incision of the compartment. Because the tendons can become recompressed or redislocate if the sutures are too tight or loose, respectively, we achieve proper tension by suturing the flaps with the patient fully awake, under local anesthesia, and without a tourniquet...
August 31, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28861517/the-microtubule-stabilizing-protein-clasp1-associates-with-the-theileria-annulata-schizont-surface-via-its-kinetochore-binding-domain
#12
Sandra Huber, Romina Theiler, Daniel de Quervain, Olga Wiens, Tulin Karangenc, Volker Heussler, Dirk Dobbelaere, Kerry Woods
Theileria is an apicomplexan parasite whose presence within the cytoplasm of a leukocyte induces cellular transformation and causes uncontrolled proliferation and clonal expansion of the infected cell. The intracellular schizont utilizes the host cell's own mitotic machinery to ensure its distribution to both daughter cells by associating closely with microtubules (MTs) and incorporating itself within the central spindle. We show that CLASP1, an MT-stabilizing protein that plays important roles in regulating kinetochore-MT attachment and central spindle positioning, is sequestered at the Theileria annulata schizont surface...
July 2017: MSphere
https://www.readbyqxmd.com/read/28860097/effectiveness-of-conservative-surgical-and-post-surgical-interventions-for-trigger-finger-dupuytren-s-disease-and-de-quervain-s-disease-a-systematic-review
#13
REVIEW
Bionka M Huisstede, Saskia Gladdines, Manon S Randsdorp, Bart W Koes
OBJECTIVES: To provide an evidence-based overview of the effectiveness of conservative and (post)-surgical interventions for trigger finger, Dupuytren's -, and De Quervain's disease. DATA SOURCES: The Cochrane Library, PEDro, PubMed, Embase and CINAHL were searched to identify relevant systematic reviews and RCTs. DATA SELECTION AND EXTRACTION: Two reviewers independently extracted the data, and assessed the methodological quality. DATA SYNTHESIS: A best-evidence synthesis was performed to summarize the results...
August 28, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28858099/a-novel-classification-of-the-anatomical-variations-of-the-first-extensor-compartment
#14
Zheng-Yu Gao, Hao Tao, Hao Xu, Jun-Qiang Xue, Yao Ou-Yang, Ji-Xia Wu
The presence of a septum in the first extensor compartment is closely associated with the pathophysiology of de Quervain disease, and affects the efficacy of corticosteroid injection and surgical release. This study aimed to examine the incidence and length of the first extensor compartment septum.Forty sides of the wrists in 20 cadavers were used. The presence of a septum in the first extensor compartment was examined. The septum length was recorded with the radial styloid process as the reference point.The anatomical variations of the first extensor compartment were classified into 3 types...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28852356/detection-of-retained-foreign-objects-in-upper-extremity-surgical-procedures-with-incisions-of-two-centimeters-or-smaller
#15
Josef N Tofte, Lindsey S Caldwell
BACKGROUND: While the true incidence of retained foreign bodies after surgery is unknown, it has been approximated at 1:5,500 operations overall, with substantially less frequency in hand and upper extremity procedures. Despite the rarity of foreign body retention in hand and upper extremity surgery, universal radiofrequency scanning for electronically-tagged sponges and automatic radiographic evaluation for incorrect sponge counts are employed for all surgical procedures at our institution...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28836453/readability-of-the-most-commonly-accessed-online-patient-education-materials-pertaining-to-pathology-of-the-hand
#16
Sheriff D Akinleye, Garret Garofolo-Gonzalez, Michael Montuori, Maya Deza Culbertson, Jennifer Hashem, David Marc Edelstein
BACKGROUND: The American Medical Association (AMA) and National Institutes of Health (NIH) recommend that patient education materials be written at no higher than a sixth-grade reading level. METHODS: We examined 100 online educational materials for the 10 hand conditions most commonly treated by hand surgeons, as reported by the American Society for Surgery of the Hand. The listed conditions were carpal tunnel syndrome, basal joint arthritis of the thumb, de Quervain syndrome, Dupuytren's contracture, ganglion cysts, hand fractures, trigger finger, extensor tendon injuries, flexor tendon injuries, and mallet finger...
August 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28811061/surgical-demographics-of-carpal-tunnel-syndrome-and-cubital-tunnel-syndrome-over-5-years-at-a-single-institution
#17
Dafang Zhang, Jamie E Collins, Brandon E Earp, Philip Blazar
PURPOSE: Carpal tunnel and cubital tunnel syndrome are the 2 most common upper-limb compressive neuropathies. However, whether the characteristics of patient populations undergoing surgery for these conditions are similar is unclear in terms of demographics and concomitant pathologies. Our null hypothesis was that there are no identifiable differences between these patient populations. METHODS: A retrospective cohort study was performed by billing system query using Common Procedural Terminology (CPT) codes for all patients who underwent open carpal tunnel release (CTR) (CPT code 64721) and/or open cubital tunnel surgery (CPT code 64718) by 1 of 4 hand surgeons from August 2008 to July 2013...
November 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28806831/clinical-sign-for-missed-decompression-of-a-separate-extensor-pollicis-brevis-compartment-in-de-quervain-s-disease
#18
Niels Benatar
Persistent pain despite previous surgery for de Quervain's disease might be due to an overlooked septum between the abductor pollicis longus tendon slips and the extensor pollicis brevis tendon, or an overlooked completely separate compartment for the extensor pollicis brevis tendon alone. In both of these instances, extension of the MP joint of the thumb against resistance elicits pain at the distal level of the first extensor compartment of the wrist. When this sign is positive, revisional surgery and decompression of the remaining septum or separate compartment is indicated...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28790188/noradrenergic-activation-of-the-basolateral-amygdala-maintains-hippocampus-dependent-accuracy-of-remote-memory
#19
Erika Atucha, Vanja Vukojevic, Raquel V Fornari, Giacomo Ronzoni, Philippe Demougin, Fabian Peter, Piray Atsak, Marcel W Coolen, Andreas Papassotiropoulos, James L McGaugh, Dominique J-F de Quervain, Benno Roozendaal
Emotional enhancement of memory by noradrenergic mechanisms is well-described, but the long-term consequences of such enhancement are poorly understood. Over time, memory traces are thought to undergo a neural reorganization, that is, a systems consolidation, during which they are, at least partly, transferred from the hippocampus to neocortical networks. This transfer is accompanied by a decrease in episodic detailedness. Here we investigated whether norepinephrine (NE) administration into the basolateral amygdala after training on an inhibitory avoidance discrimination task, comprising two distinct training contexts, alters systems consolidation dynamics to maintain episodic-like accuracy and hippocampus dependency of remote memory...
August 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28729929/picture-free-recall-performance-linked-to-the-brain-s-structural-connectome
#20
David Coynel, Leo Gschwind, Matthias Fastenrath, Virginie Freytag, Annette Milnik, Klara Spalek, Andreas Papassotiropoulos, Dominique J-F de Quervain
INTRODUCTION: Memory functions are highly variable between healthy humans. The neural correlates of this variability remain largely unknown. METHODS: Here, we investigated how differences in free recall performance are associated with DTI-based properties of the brain's structural connectome and with grey matter volumes in 664 healthy young individuals tested in the same MR scanner. RESULTS: Global structural connectivity, but not overall or regional grey matter volumes, positively correlated with recall performance...
July 2017: Brain and Behavior
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