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Ankur Goyal, Deep Narayan Srivastava, Tahir Ansari
No abstract text is available yet for this article.
March 2018: AJR. American Journal of Roentgenology
Michael S Brown, Seema Meraj, Daniel Walz
No abstract text is available yet for this article.
March 2018: AJR. American Journal of Roentgenology
Alexander R Poublon, Gert-Jan Kleinrensink, Anton LA Kerver, J Henk Coert, Erik T Walbeehm
AIM: To determine which of the common used incision techniques has the lowest chance of iatrogenic damage to the nerves which at risk are the superficial branch of the radial nerve (SBRN) and the Lateral Antebrachial Cutaneous Nerve (LABCN). METHODS: Twenty embalmed arms were dissected and the course of the SBRN and the LABCN in each individual arm was marked and the distance between the two branches of the SBRN at the location of the First Extensor Compartment (FEC) was measured...
February 18, 2018: World Journal of Orthopedics
Tobias Egli, David Coynel, Klara Spalek, Matthias Fastenrath, Virginie Freytag, Angela Heck, Eva Loos, Bianca Auschra, Andreas Papassotiropoulos, Dominique J-F de Quervain, Annette Milnik
Working memory (WM) is an important cognitive domain for everyday life functioning and is often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies in humans show that distributed brain areas typically described as fronto-parietal regions are implicated in WM tasks. Based on data from a large sample of healthy young adults ( N = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal and identified two distinct networks that were relevant for differences in individual WM task performance...
January 2018: ENeuro
Kevin Li, Tanmaya D Sambare, Sam Y Jiang, Emily J Shearer, Nathan P Douglass, Robin N Kamal
BACKGROUND: Antibiotic prophylaxis is a common but controversial practice for clean soft tissue procedures of the hand, such as carpal tunnel release or trigger finger release. Previous studies report no substantial reduction in the risk of surgical site infection (SSI) after antibiotic prophylaxis, yet are limited in power by low sample sizes and low overall rates of postoperative infection. QUESTIONS/PURPOSES: Is there evidence that antibiotic prophylaxis decreases the risk of SSI after soft tissue hand surgery when using propensity score matching to control for potential confounding variables such as demographics, procedure type, medication use, existing comorbidities, and postoperative events? METHODS: This retrospective analysis used the Truven Health MarketScan databases, large, multistate commercial insurance claims databases corresponding to inpatient and outpatient services and outpatient drug claims made between January 2007 and December 2014...
February 8, 2018: Clinical Orthopaedics and related Research
Shepard P Johnson, Lin Zhong, Kevin C Chung, Jennifer F Waljee
PURPOSE: Given that surgical site infections remain a common performance metric in assessing the quality of health care, we hypothesized that prophylactic antibiotics are overutilized in soft tissue hand surgery when antimicrobials are not indicated. METHODS: We studied insurance claims from the Truven MarketScan Databases to identify patients who underwent 1 of 5 outpatient hand surgery procedures: open or endoscopic carpal tunnel release, trigger finger release, de Quervain release, and wrist ganglion excision between 2009 and 2015 (n = 305,946)...
February 2, 2018: Journal of Hand Surgery
Edel Kelly, Richard Ellis, Wayne Hing
STUDY DESIGN: Cross-sectional, observational study. INTRODUCTION: There is little reported on the in vivo mechanics and behavior of extensor pollicis brevis (EPB) in relation to wrist position. Wrist position is known to significantly influence tendon excursion and therefore function of the digits. Ultrasound imaging (USI) can be used to assess in vivo tendon behavior and excursion. An improved knowledge of the excursion of the EPB tendon is important in understanding normal tendon mechanics and potentially pathological tendon disorders such as de Quervains tenosynovitis...
January 29, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Daan Renson, Koen Mermuys, Bert Vanmierlo, Francis Bonte, Petrus Van Hoonacker, Diederick Kerckhove, Bart Berghs, Jean F Goubau
Background  Surgical management of de Quervain's tenosynovitis is based on decompression of the first extensor compartment. A simple release of the first compartment can cause instability of the extensor pollicis brevis (EPB) and abductor pollicis longus (APL) tendons in zone seven of the extensors. The WHAT test (wrist hyperflexion and abduction of the thumb) is very effective in diagnosing this instability. Patients and Methods  In this retrospective monocentric study, we analyzed a case series of 10 patients all of whom underwent a reconstruction of the first extensor compartment using a retinacular graft because of symptomatic instability after decompression surgery...
February 2018: Journal of Wrist Surgery
Virginie Freytag, Vanja Vukojevic, Holger Wagner-Thelen, Annette Milnik, Christian Vogler, Markus Leber, Leonie Weinhold, Anne C Böhmer, Steffi Riedel-Heller, Wolfgang Maier, Dominique J-F de Quervain, Alfredo Ramirez, Andreas Papassotiropoulos
The large biological distance between genetic risk loci and their mechanistic consequences in the tissue of interest limits the ability to establish functionality of susceptibility variants for genetically complex traits. Such a biological gap may be reduced through the systematic study of molecular mediators of genomic action, such as epigenetic modification. Here, we report the identification of robust genetic estimators of whole-blood CpG methylation, which can serve as intermediate molecular traits amenable to association testing with other genetically complex traits...
January 31, 2018: Translational Psychiatry
Carlo Milani, Cindy Lin
De Quervain tenosynovitis is a stenosing tenosynovitis of the first dorsal compartment of the wrist that can lead to painful functional impairment of the upper limb. This case report describes a rare adverse effect of corticosteroid injection which is local skin atrophy and hypopigmentation with proximal linear extension. In this case, hypopigmentation developed from the wrist to beyond the elbow after corticosteroid injection with ultrasound guidance and targeted placement of the injectate in the extensor tendon sheath of the first dorsal compartment...
January 17, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Jeffrey G Stepan, Daniel A London, Daniel A Osei, Martin I Boyer, Agnes Z Dardas, Ryan P Calfee
PURPOSE: Prescription opioid abuse is an epidemic in the United States; multimodal analgesia has been suggested as a potential solution to decrease postoperative opioid use. The primary aim of this study was to determine the effect of perioperative celecoxib on opioid intake. Secondary goals were to determine whether perioperative administration of celecoxib decreased postoperative patient-reported pain and whether patient demographic characteristics could predict postoperative pain and opioid intake...
December 21, 2017: Journal of Hand Surgery
Léonie Geissmann, Leo Gschwind, Nathalie Schicktanz, Gunnar Deuring, Timm Rosburg, Kyrill Schwegler, Christiane Gerhards, Annette Milnik, Marlon O Pflueger, Ralph Mager, Dominique J F de Quervain, David Coynel
While much is known about immediate brain activity changes induced by the confrontation with emotional stimuli, the subsequent temporal unfolding of emotions has yet to be explored. To investigate whether exposure to emotionally aversive pictures affects subsequent resting-state networks differently from exposure to neutral pictures, a resting-state fMRI study implementing a two-group repeated-measures design in healthy young adults (N = 34) was conducted. We focused on investigating (i) patterns of amygdala whole-brain and hippocampus connectivity in both a seed-to-voxel and seed-to-seed approach, (ii) whole-brain resting-state networks with an independent component analysis coupled with dual regression, and (iii) the amygdala's fractional amplitude of low frequency fluctuations, all while EEG recording potential fluctuations in vigilance...
November 22, 2017: NeuroImage
Matthew P Murphy, Christina Buckley, Conor Sugrue, Emma Carr, Aine O'Reilly, Shane O'Neill, Sean M Carroll
BACKGROUND: The first carpometacarpal joint (CMCJ) in the hand is a commonly affected joint by osteoarthritis. It causes significant thumb base pain, limiting functional capacity. Microfracturing and application of autologous stem cells has been performed on large joints such as the knee but has never been evaluated for use in the smaller joints in the hand. Our aim was to determine the potential benefit of microfracturing and autologous bone marrow stem cells for treatment of osteoarthritis of the first CMCJ in the hand...
September 2017: Plastic and Reconstructive Surgery. Global Open
Tobias Egli, Vanja Vukojevic, Thierry Sengstag, Martin Jacquot, Rubén Cabezón, David Coynel, Virginie Freytag, Angela Heck, Christian Vogler, Dominique J-F de Quervain, Andreas Papassotiropoulos, Annette Milnik
Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which in concert decrease model stability. An additional source introducing significant uncertainty with regard to the detection of robust epistasis is the biological distance between the genetic variation and the trait under study. Here we studied CpG methylation, a genetically complex molecular trait that is particularly close to genomic variation, and performed an exhaustive search for two-locus epistatic effects on the CpG-methylation signal in two cohorts of healthy young subjects...
October 20, 2017: Scientific Reports
Abdallah El-Sayed Allam, Doaa Shawky Al-Ashkar, Ahmed A Negm, Basma Aly Eltawab, Wei-Ting Wu, Ke-Vin Chang
De Quervain disease (DQVD) is one of the most common causes of lateral wrist pain and can lead to significant disability. The current case involves a right-handed, middle-aged, female patient with severe lateral wrist pain due to DQVD. Her pain was not responsive to oral non-steroidal anti-inflammatory drugs, rehabilitation, and repeated corticosteroid injections. Because she refused surgical intervention, we performed ultrasound-guided methotrexate injections (four times). After the injections, dramatic pain relief, functional improvement, and reduction of the thickness of the retinaculum and tendons in the first dorsal extensor compartment of the wrist were noted...
2017: Journal of Pain Research
Ozan Volkan Yurdakul, Lütfiye Aytüre, Ebru Yilmaz Yalçinkaya
BACKGROUND: Growth hormone deficiency is a well-known clinical entity that is usually treated with somatotropin (growth hormone). Growth hormone has some frequent side effects such as intracranial hypertension, lymphedema and diabetes mellitus. CASE PRESENTATION: We report the case of a 14-year-old girl with a history of wrist pain and clumsiness. Magnetic resonance imaging revealed de Quervain tenosynovitis. The patient had a history of using growth hormones for 12 months...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
Rustu Turkay, Ercan Inci, Banu Aydeniz, Meltem Vural
OBJECTIVE: Our aim was to evaluate the feasibility of using shear wave elastography (SWE) to assess first extensor compartment tendons rigidity and its alterations with tenosynovitis. MATERIALS AND METHODS: We performed B-mode ultrasound and SWE to total number of 80 participants. All participants were evaluated clinically to call the diagnosis of de Quervain tenosynovitis or to rule out the diagnosis. We composed 2 groups. Group 1 included 40 healthy volunteers (33 females and 7 male participants with ages ranging from 24 to 60 years, median age was 37...
October 2017: European Journal of Radiology
Stuart K Kim, Marwa A Ahmed, Andy L Avins, John P A Ioannidis
De Quervain's tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain's tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls...
November 2017: International Journal of Sports Medicine
Rachna Lamichaney, Mingma Sherpa, Deepak Das, Chumila Thinley Bhutia, Sabina Laishram
INTRODUCTION: De Quervain's Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesions. AIM: The objective of this study was to reveal the cytological characteristics of DQT. MATERIALS AND METHODS: We retrospectively reviewed the clinical and FNAC findings of 20 cases of DQT to find the most reliable features for a confident cytological diagnosis...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
Sandra Huber, Romina Theiler, Daniel de Quervain, Olga Wiens, Tulin Karagenc, Volker Heussler, Dirk Dobbelaere, Kerry Woods
[This corrects the article DOI: 10.1128/mSphere.00215-17.].
September 2017: MSphere
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