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Influenza vaccines

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https://www.readbyqxmd.com/read/29054729/hib-antibody-responses-in-infants-following-diphtheria-tetanus-acellular-pertussis-and-conjugated-haemophilus-influenzae-type-b-hib-combination-vaccines-with-decreasing-amounts-of-tetanus-toxoid
#1
Henry H Bernstein, Elisabeth R Seyferth
BACKGROUND: While combination vaccines have contributed to improved vaccine uptake rates in children, studies have documented varied immunogenicity to specific vaccine components. We studied whether varying the amount of tetanus toxoid (TT) in a DTaP and Hib combination vaccine would result in immunogenicity comparable with separate, concurrent administration. METHODS: We evaluated the immunogenicity of Massachusetts Biologic Laboratories (MBL) diphtheria, tetanus, and acellular pertussis (mDTaP) vaccine combined with tetanus-conjugated MBL Haemophilus influenzae type b vaccine (mHib) in a single injection (DTaPH)...
October 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29054116/t-cell-epitope-content-comparison-epicc-of-swine-h1-influenza-a-virus-hemagglutinin
#2
Andres H Gutiérrez, Vicki Rapp-Gabrielson, Frances E Terry, Crystal Loving, Leonard Moise, William D Martin, Anne S De Groot
BACKGROUND: Predicting vaccine efficacy against emerging pathogen strains is a significant problem in human and animal vaccine design. T cell epitope cross-conservation may play an important role in cross-strain vaccine efficacy. While influenza A virus (IAV) hemagglutination inhibition (HI) antibody titers are widely used to predict protective efficacy of one IAV vaccine against new strains, no similar correlate of protection has been identified for T cell epitopes. OBJECTIVE: We developed a computational method (EpiCC) that facilitates pairwise comparison of protein sequences based on an immunological property - T cell epitope content - rather than sequence identity, and evaluated its ability to classify swine IAV strain relatedness to estimate cross-protective potential of a vaccine strain for circulating viruses...
October 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29054110/mortality-burden-from-seasonal-influenza-and-2009-h1n1-pandemic-influenza-in-beijing-china-2007-2013
#3
REVIEW
Shuangsheng Wu, Zaihua Wei, Carolyn M Greene, Peng Yang, Jianting Su, Ying Song, A Danielle Iuliano, Quanyi Wang
BACKGROUND: Data about influenza mortality burden in northern China are limited. This study estimated mortality burden in Beijing associated with seasonal influenza from 2007-2013 and the 2009 H1N1 pandemic. METHODS: We estimated influenza-associated excess mortality by fitting a negative binomial model using weekly mortality data as the outcome of interest with the percent of influenza positive samples by type/subtype as predictor variables. RESULTS: From 2007 to 2013, an average of 2,375 (CI 1,002-8,688) deaths was attributed to influenza per season, accounting for 3% of all deaths...
October 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29053938/development-of-a-nanogel-based-nasal-vaccine-as-a-novel-antigen-delivery-system
#4
Rika Nakahashi-Ouchida, Yoshikazu Yuki, Hiroshi Kiyono
Nasal vaccination is one of the most effective immunization methods because it can induce effective antigen-specific immune responses not only at the mucosal site of administration but also at distant mucosal surfaces, as well as in the systemic compartment. Based on this advantage, many nasal vaccines are being developed and some have been licensed and marketed for clinical use. However, some have been withdrawn because of unacceptable adverse events such as inactivated influenza vaccine administrated with a heat-labile enterotoxin of Escherichia coli as an adjuvant...
October 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29053369/effects-of-message-framing-on-influenza-vaccination-understanding-the-role-of-risk-disclosure-perceived-vaccine-efficacy-and-felt-ambivalence
#5
Sungsu Kim, Ivanka Pjesivac, Yan Jin
The current study examined the effects of framing in promotional health messages on intention to vaccinate against seasonal influenza virus. The findings of an experimental study (N = 86) indicated that exposure to both benefits and side effects of vaccination (gain-framed with risk disclosure message) led to lower intention to receive the flu vaccine. This relationship was mediated by both perceived vaccine efficacy and felt ambivalence in a serial order, revealing the underlying psychological mechanisms important for understanding health-related behaviors...
October 20, 2017: Health Communication
https://www.readbyqxmd.com/read/29052410/zoonotic-influenza-viruses-antigenic-and-genetic-characteristics-and-development-of-candidate-vaccine-viruses-for-pandemic-preparedness
#6
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/29052409/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2018-southern-hemisphere-influenza-season
#7
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/29051018/access-to-employee-wellness-programs-and-use-of-preventive-care-services-among-u-s-adults
#8
Oluwaseyi O Isehunwa, Erik L Carlton, Yang Wang, Yu Jiang, Satish Kedia, Cyril F Chang, Daniel Fijabi, Soumitra S Bhuyan
INTRODUCTION: There is little research at the national level on access to employee wellness programs and the use of preventive care services. This study examined the use of seven preventive care services among U.S working adults with access to employee wellness programs. METHODS: The study population comprised 17,699 working adults aged ≥18 years, obtained from the 2015 National Health Interview Survey. Multivariate logistic regression models examined the relationship between access to employee wellness programs and use of seven preventive care services: influenza vaccination, blood pressure check, diabetes check, cholesterol check, Pap smear test, mammogram, and colon cancer screening...
October 16, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29050992/the-impact-of-13-valent-pneumococcal-conjugate-vaccination-on-virus-associated-community-acquired-pneumonia-in-elderly
#9
Susanne M Huijts, Frank E J Coenjaerts, Marieke Bolkenbaas, Cornelis H van Werkhoven, Diederick E Grobbee, Marc J M Bonten
OBJECTIVES: Our objective was to evaluate whether vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) prevents the incidence of community-acquired pneumonia (CAP) caused by influenza (Influenza-Associated CAP, IA-CAP) or other respiratory viruses in elderly. METHODS: This analysis was part of the Community-Acquired Pneumonia immunization Trial in Adults (CAPiTA); a double blind, randomized, placebo-controlled trial in 84,496 immunocompetent individuals aged ≥65 years...
October 16, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29050439/pathogenicity-and-immunosuppressive-potential-of-fowl-adenovirus-in-specific-pathogen-free-chickens
#10
Yujuan Niu, Qinqin Sun, Guihua Zhang, Wei Sun, Xingpo Liu, Yihong Xiao, Yingli Shang, Sidang Liu
To elucidate the effect of fowl adenovirus (FAdV)-C in specific-pathogen-free (SPF) chickens, we investigated the pathogenicity, body weights, enzymatic systems, and immune organs of chickens in response to Newcastle disease virus (NDV) and avian influenza virus subtype H9 (AIV-H9) vaccination. Chickens were divided randomly into four groups, which included injection groups (FAdV-C, vaccination, and FAdV-C plus vaccination) and a negative control group. The results indicated that FAdV-C was highly pathogenic in SPF chickens and led to a 40% mortality rate and growth retardation, compared with the control birds...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29049310/molecular-epidemiology-of-influenza-b-virus-among-hospitalized-pediatric-patients-in-northern-italy-during-the-2015-16-season
#11
Antonio Piralla, Giovanna Lunghi, Luca Ruggiero, Alessia Girello, Sonia Bianchini, Francesca Rovida, Silvia Caimmi, Gian Luigi Marseglia, Nicola Principi, Fausto Baldanti, Susanna Esposito
BACKGROUND: The influenza B viruses belong to two lineages distinguished by their genetic and antigenic characteristics, which are referred to as the Yamagata and Victoria lineages, designated after their original isolates, B/Yamagata/16/88 and B/Victoria/2/87. The primary aim of this study was to evaluate the molecular characteristics of influenza B viruses circulating in a region of Northern Italy, Lombardia, during the influenza season of 2015-2016. METHODS: Influenza B virus was detected using a respiratory virus panel of assays and an influenza B-specific real-time polymerase chain reaction...
2017: PloS One
https://www.readbyqxmd.com/read/29049005/beliefs-attitudes-and-activities-of-healthcare-personnel-about-influenza-and-pneumococcal-vaccines
#12
Fatma Çiftci, Elif Şen, Nalan Demir, Orçun Çiftci, Serhat Erol, Oya Kayacan
OBJECTIVES: Vaccination of healthcare personnel (HCP) is an effective measure for preventing the spread of influenza among at-risk patients. This study was conducted to determine influenza vaccination rates and activities among HCP working at a tertiary healthcare setting. METHODS: This study included 470 HCP (85 physicians, 134 nurses, 53 healthcare assistants, 44 paramedics, 47 medical secretaries, and 107 auxillary staff members) working at the emergency, cardiology, chest diseases, and internal medicine departments with the largest volume of patients with vaccination indication of two large university hospitals with similar medical practices and work environment...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29049002/cost-effectiveness-of-the-haemophilus-influenzae-type-b-vaccine-for-infants-in-mainland-china
#13
Guijun Ning, Zundong Yin, Yixing Li, Huaqing Wang, Weizhong Yang
OBJECTIVE: The aims of this study were to estimate the cost-effectiveness of the Haemophilus influenzae type b (Hib) vaccine for the prevention of childhood pneumonia, meningitis and other vaccine-preventable diseases in mainland China from a societal perspective and to provide information about the addition of the Hib vaccine to Chinese immunization programs. METHODS: A decision tree and the Markov model were used to estimate the costs and effectiveness of the Hib vaccine versus no Hib vaccine for a birth cohort of 100,000 children in 2016...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048990/title-site-specific-glycosylation-profile-of-influenza-a-h1n1-hemagglutinin-through-tandem-mass-spectrometry
#14
Esteban Cruz, Joel Cain, Ben Crossett, Veysel Kayser
The study of influenza virus evolution in humans has revealed a significant role of glycosylation profile alterations in the viral glycoproteins - hemagglutinin (HA) and neuraminidase (NA), in the emergence of both seasonal and pandemic strains. Viral antigenic drift can modify the number and location of glycosylation sites, altering a wide range of biological activities and the antigenic properties of the strain. In view of the key role of glycans in determining antigenicity, elucidating the glycosylation profiles of influenza strains is a requirement towards the development of improved vaccines...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048989/vaccination-in-pregnancy-attitudes-of-nurses-midwives-and-health-visitors-in-england
#15
Bhavita Vishram, Louise Letley, Albert Jan Van Hoek, Louise Silverton, Helen Donovan, Cheryll Adams, David Green, Angela Edwards, Joanne Yarwood, Helen Bedford, Gayatri Amirthalingam, Helen Campbell
OBJECTIVE: To examine amongst healthcare professionals in England; knowledge of vaccinations in pregnancy, their perceived roles in these programmes and whether they recommend scheduled vaccines to pregnant women. DESIGN: Cross sectional survey (online questionnaire) Setting: Healthcare workers in contact with pregnant women in England. PARTICIPANTS: The survey analysis included 3441 healthcare workers who had been surveyed during May to August 2015...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29047305/influenza-vaccine-response-future-perspectives
#16
Chiara Mameli, Enza D'auria, Paola Erba, Pilar Nannini, Gian Vincenzo Zuccotti
No abstract text is available yet for this article.
October 19, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29046666/molecular-serotype-specific-identification-of-non-type-b-haemophilus-influenzae-by-loop-mediated-isothermal-amplification
#17
Chika Takano, Mitsuko Seki, Dong Wook Kim, Paul E Kilgore, Kazumasa Fuwa, Koji Takahashi, Toshiaki Inazaki, Satoshi Hayakawa
Over the past four decades, the incidence of meningitis caused by Haemophilus influenzae in children has decreased due to widespread vaccination against H. influenzae type b (Hib). The incidence of invasive diseases due to H. influenzae types not included in the vaccines, however, has increased. At present, there are a limited number of diagnostics available to detect non-type b H. influenzae. To address this issue, we developed a rapid, simple, and cost-effective method for detecting serotypes of H. influenzae...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046481/reevaluation-of-immune-activation-in-the-era-of-cart-and-an-aging-hiv-infected-population
#18
Lesley R de Armas, Suresh Pallikkuth, Varghese George, Stefano Rinaldi, Rajendra Pahwa, Kristopher L Arheart, Savita Pahwa
Biological aging is associated with immune activation (IA) and declining immunity due to systemic inflammation. It is widely accepted that HIV infection causes persistent IA and premature immune senescence despite effective antiretroviral therapy and virologic suppression; however, the effects of combined HIV infection and aging are not well defined. Here, we assessed the relationship between markers of IA and inflammation during biological aging in HIV-infected and -uninfected populations. Antibody response to seasonal influenza vaccination was implemented as a measure of immune competence and relationships between IA, inflammation, and antibody responses were explored using statistical modeling appropriate for integrating high-dimensional data sets...
October 19, 2017: JCI Insight
https://www.readbyqxmd.com/read/29046464/screening-for-neuraminidase-inhibitor-resistance-markers-among-avian-influenza-viruses-of-the-n4-n5-n6-and-n8-neuraminidase-subtypes
#19
Won-Suk Choi, Ju Hwan Jeong, Jin Jung Kwon, Su Jeong Ahn, Khristine Kaith S Lloren, Hyeok-Il Kwon, Hee Bok Chae, Jungwon Hwang, Myung Hee Kim, Chul-Joong Kim, Richard J Webby, Elena A Govorkova, Young Ki Choi, Yun Hee Baek, Min-Suk Song
Several subtypes of avian influenza viruses (AIVs) are emerging as novel human pathogens, and the frequency of related infections has increased in recent years. Although neuraminidase (NA) inhibitors (NAIs) are the only class of antiviral drugs available for therapeutic intervention for AIV-infected patients, studies on NAI resistance among AIVs have been limited and markers of resistance are poorly understood. Previously, we identified unique NAI-resistance substitutions in AIVs of N3, N7, and N9 NA subtypes...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046433/a-multimechanistic-antibody-targeting-the-receptor-binding-site-potently-cross-protects-against-influenza-b-viruses
#20
Chenguang Shen, Junyu Chen, Rui Li, Mengya Zhang, Guosong Wang, Svetlana Stegalkina, Limin Zhang, Jing Chen, Jianli Cao, Xingjian Bi, Stephen F Anderson, Timothy Alefantis, Minwei Zhang, Xiaoyang Cai, Kunyu Yang, Qingbing Zheng, Mujing Fang, Hai Yu, Wenxin Luo, Zizheng Zheng, Quan Yuan, Jun Zhang, James Wai-Kuo Shih, Harry Kleanthous, Honglin Chen, Yixin Chen, Ningshao Xia
Influenza B virus causes considerable disease burden worldwide annually, highlighting the limitations of current influenza vaccines and antiviral drugs. In recent years, broadly neutralizing antibodies (bnAbs) against hemagglutinin (HA) have emerged as a new approach for combating influenza. We describe the generation and characterization of a chimeric monoclonal antibody, C12G6, that cross-neutralizes representative viruses spanning the 76 years of influenza B antigenic evolution since 1940, including viruses belonging to the Yamagata, Victoria, and earlier lineages...
October 18, 2017: Science Translational Medicine
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