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Influenza vaccines

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https://www.readbyqxmd.com/read/29913102/immunization-rates-of-pneumococcal-influenza-and-tetanus-vaccines-and-knowledge-and-attitudes-of-adult-patients-who-receive-inpatient-treatment-at-hospital-point-prevalence-study
#1
Aziz Ahmad hamİdİ, Beray Gelmez taŞ, Alper GÜndÜz, Safiye Nur Çelebİ, Elif Serap Esen, Dilek Toprak, İlyas DÖkmetaŞ
The safety of vaccines, access to health care, the level of community's knowledge and the attention of physicians play a critical role in the rate of adult vaccination. This study aims to determine the immunization rate of pneumococcal, influenza and tetanus vaccines among the patients and their knowledge and attitudes in the hospital. The study is a cross-sectional point prevalence survey. The patients who agreed to participate in the study were interviewed using a questionnaire. Patients' gender, occupation, educational status, income level and risk factors (immunosuppressed and over 65 years old) were compared with the knowledge and attitudes about vaccinations...
June 18, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29912696/registry-cohort-study-to-determine-risk-for-multiple-sclerosis-after-vaccination-for-pandemic-influenza-a-h1n1-with-arepanrix-manitoba-canada
#2
Salaheddin M Mahmud, Songul Bozat-Emre, Luiz C Mostaço-Guidolin, Ruth Ann Marrie
To investigate a potential risk for multiple sclerosis (MS) after vaccination with Arepanrix, the GlaxoSmithKline AS03-adjuvanted influenza A(H1N1)pdm09 vaccine, we used the provincewide immunization registry for Manitoba, Canada, to match 341,347 persons vaccinated during the 2009 pandemic to 485,941 unvaccinated persons on age, sex, address, and a propensity score measuring the probability of vaccination. We used a previously validated algorithm to identify MS cases from provincial hospital, physician, and prescription drug claims databases...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912681/progress-and-remaining-gaps-in-estimating-the-global-disease-burden-of-influenza
#3
Joseph Bresee, Julia Fitzner, Harry Campbell, Cheryl Cohen, Vanessa Cozza, Jorge Jara, Anand Krishnan, Vernon Lee
Influenza has long been a global public health priority because of the threat of another global pandemic. Although data are available for the annual burden of seasonal influenza in many developed countries, fewer disease burden data are available for low-income and tropical countries. In recent years, however, the surveillance systems created as part of national pandemic preparedness efforts have produced substantial data on the epidemiology and impact of influenza in countries where data were sparse. These data are leading to greater interest in seasonal influenza, including implementation of vaccination programs...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912453/induction-of-cross-clade-antibody-and-t-cell-responses-by-an-mva-based-influenza-h5n1-vaccine-in-a-randomized-phase-i-iia-clinical-trial
#4
Rory D de Vries, Arwen F Altenburg, Nella J Nieuwkoop, Erwin de Bruin, Stella E van Trierum, Mark R Pronk, Mart M Lamers, Mathilde Richard, David F Nieuwenhuijse, Marion P G Koopmans, Joost H C M Kreijtz, Ron A M Fouchier, Albert D M E Osterhaus, Gerd Sutter, Guus F Rimmelzwaan
Background: Highly pathogenic avian influenza viruses continue to circulate in poultry and wild birds and occasionally infect humans, sometimes with fatal outcome. Development of vaccines is a priority to prepare for potential pandemics, however complicated by antigenic variation of the surface glycoprotein hemagglutinin. We report the immunological profile induced by human immunization with Modified Vaccinia virus Ankara expressing the hemagglutinin gene of H5N1 virus A/Vietnam/1194/04 (rMVA-H5)...
April 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29911996/altered-immune-cell-follicular-dynamics-in-hiv-infection-following-influenza-vaccination
#5
Eirini Moysi, Suresh Pallikkuth, Leslie R De Armas, Louis E Gonzalez, David Ambrozak, Varghese George, David Huddleston, Rajendra Pahwa, Richard A Koup, Constantinos Petrovas, Savita Pahwa
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral therapy (cART) are not clear. We obtained LN biopsies before and 10 to 14 days after trivalent seasonal influenza immunization from healthy controls (HCs) and HIV+ volunteers on cART to investigate CD4+ T follicular helper (Tfh) and B cell dynamics by flow cytometry and quantitative imaging analysis...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29911046/vaccination-status-knowledge-and-acceptance-of-adult-vaccinations-against-respiratory-illness-among-patients-with-type-2-diabetes-mellitus
#6
Christeena Geneev, Nisha Mathew, Jubbin Jagan Jacob
Patients with diabetes mellitus are more prone to develop infections with influenza virus and pneumococcus. Once they develop respiratory infections, they are twice more likely to die of complication related to the infection. Although there are no Indian guidelines, recent publications have recommended vaccination in patients with diabetes of all ages. Our study was undertaken to find the barriers to the uptake of adult vaccination against respiratory illness among patients with diabetes attending a diabetic clinic in a tertiary care institution...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910118/rct-of-centralized-vaccine-reminder-recall-for-adults
#7
Laura P Hurley, Brenda Beaty, Steven Lockhart, Dennis Gurfinkel, Kristin Breslin, Miriam Dickinson, Melanie D Whittington, Heather Roth, Allison Kempe
INTRODUCTION: A proven, but underutilized, method to increase current low vaccination rates is reminder/recall. Centralized reminder/recall using an Immunization Information System reduces the burden of an individual practice conducting reminder/recall. The objectives were to assess the effectiveness of centralized vaccine reminder/recall on improving adult vaccination rates using Colorado's Immunization Information System. STUDY DESIGN: This study is a pragmatic RCT...
June 14, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29909156/high-dose-influenza-vaccine-to-reduce-clinical-outcomes-in-high-risk-cardiovascular-patients-rationale-and-design-of-the-invested-trial
#8
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909132/receipt-of-other-routinely-recommended-vaccines-relative-to-receipt-of-seasonal-influenza-vaccines-trends-from-medicare-administrative-data-2013-2015
#9
Angela K Shen, Rob Warnock, Steve Chu, Jeffrey A Kelman
Annual influenza vaccination campaigns emphasize the importance of getting vaccinated against influenza. These campaigns offer potential opportunities to raise awareness of all vaccines. We explored the peak timing of the receipt of influenza and other routinely recommended vaccinations. We examined administrative claims data of 31 million Medicare fee-for-service beneficiaries, eligible to receive vaccinations administered from 2013 to 2015 from Medicare Part B (medical insurance) and Medicare Part D (prescription drug benefit)...
June 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29908209/the-second-generation-thiazolide-haloxanide-is-a-potent-inhibitor-of-avian-influenza-virus-replication
#10
Simone La Frazia, Sara Piacentini, Anna Riccio, Jean Francois Rossignol, M Gabriella Santoro
The emergence of new avian influenza virus (AIV) strains able to infect humans represents a serious threat to global human health. In addition to surveillance and vaccine development, antiviral therapy remains crucial for AIV control; however, the increase in drug-resistant AIV strains underscores the need for novel approaches to anti-influenza chemotherapy. We have previously shown that the thiazolide anti-infective nitazoxanide (NTZ) inhibits influenza A/PuertoRico/8/1934(H1N1) virus replication, and this effect was associated with inhibition of viral hemagglutinin (HA) maturation...
June 13, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29908098/modelling-the-population-effectiveness-of-the-national-seasonal-influenza-vaccination-programme-in-scotland-the-impact-of-targeting-all-individuals-aged-65-years-and-over-flu-vaccination-programme-effectiveness
#11
Stephen Corson, Chris Robertson, Arlene Reynolds, Jim McMenamin
BACKGROUND: For the last 17 years, the UK has employed a routine influenza vaccination programme with the aim of reducing the spread of seasonal influenza. In mid-2000, the programme moved from a purely risk-based approach to a risk and age group targeted approach with all those aged 65+ years being included. To date, there has been no assessment of the population effectiveness of this age targeted policy in Scotland. OBJECTIVES: Statistical modelling techniques were used to determine what impact the routine vaccination of those aged 65+ years has had on influenza related morbidity and mortality in Scotland...
June 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29907485/assessment-of-vaccine-wastage-rates-missed-opportunities-and-related-knowledge-attitudes-and-practices-during-introduction-of-a-second-dose-of-measles-containing-vaccine-into-cambodia-s-national-immunization-program
#12
Aaron S Wallace, Kong Krey, John Hustedt, Eleanor Burnett, Narin Choun, Danni Daniels, Margaret L Watkins, Sann Chan Soeung, Richard Duncan
INTRODUCTION: Missed opportunities for vaccination (MOV) can result in inadequate protection against disease. Although healthcare provider reluctance to open multi-dose, lyophilized vaccine vials (particularly the measles-containing vaccine [MCV]) for every eligible child due to concerns about wasting vaccine is a known reason for MOV, little is known about providers' related attitudes and practices. METHODS: In 100 randomly selected health facilities and 24 districts of Cambodia, we surveyed healthcare providers and their district supervisors regarding routine vaccine administration and wastage knowledge and practices, and child caregivers (five per facility) regarding MOV...
June 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29907484/patient-attitudes-toward-influenza-and-tetanus-diphtheria-and-acellular-pertussis-vaccination-in-pregnancy
#13
Emmie R Strassberg, Michael Power, Jay Schulkin, Lauren M Stark, A Dhanya Mackeen, Katie L Murtough, Michael J Paglia
BACKGROUND: Routine influenza and tetanus, diphtheria and acellular pertussis (Tdap) vaccination of pregnant women to prevent poor maternal, fetal and neonatal outcomes is recommended practice; however, actual rates of influenza vaccine acceptance are typically well below the (Healthy People 2020, 2015) goal of 80%. OBJECTIVE: We sought to identify barriers to accepting either vaccination. MATERIALS AND METHODS: From December 2014 to April 2015 women were given a questionnaire eliciting their experiences, attitudes and history of influenza and Tdap vaccination in pregnancy during their routine prenatal care appointments at a tertiary care center...
June 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29906602/cost-effectiveness-analysis-of-universal-influenza-vaccination-application-of-susceptible-infectious-complication-recovery-model
#14
Kuen-Cheh Yang, Hui-Fang Hung, Meng-Kan Chen, Li-Sheng Chen, Jean Ching-Yuan Fann, Sherry Yueh-Hsia Chiu, Amy-Ming Fang Yen, Kuo-Chin Huang, Hsiu-Hsi Chen, Sen-Te Wang
OBJECTIVES: Despite the fact that vaccination is an effective primary prevention strategy for containing influenza outbreak, health policymakers show great concern over enormous costs involved in universal immunization particularly when resources are limited. METHODS: We conducted a two-arm cost-effectiveness analysis (CEA) that takes into account the aspect of herd immunity, using a study cohort that was composed of 100,000 residents with the make-up of demographic characteristics identical to those of the underlying population in Taipei County, Taiwan, during the epidemic influenza season of 2001-2002...
June 12, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29906276/bias-due-to-differential-and-non-differential-disease-and-exposure-misclassification-in-studies-of-vaccine-effectiveness
#15
Tom De Smedt, Elizabeth Merrall, Denis Macina, Silvia Perez-Vilar, Nick Andrews, Kaatje Bollaerts
BACKGROUND: Studies of vaccine effectiveness (VE) rely on accurate identification of vaccination and cases of vaccine-preventable disease. In practice, diagnostic tests, clinical case definitions and vaccination records often present inaccuracies, leading to biased VE estimates. Previous studies investigated the impact of non-differential disease misclassification on VE estimation. METHODS: We explored, through simulation, the impact of non-differential and differential disease- and exposure misclassification when estimating VE using cohort, case-control, test-negative case-control and case-cohort designs...
2018: PloS One
https://www.readbyqxmd.com/read/29906044/case-report-respiratory-syncytial-virus
#16
Rosalinda Jiménez-Aguilar, María Eugenia Rodriguez-Godoy, Rodolfo Norberto Jiménez-Juarez, María del Carmen Cano-Salas
Background: The Respiratory Syncytial Virus (RSV) is the most important viral pathogen in children under 2 years of age, which warrants hospitalization for a low respiratory infection. 0.5% of children under 5 with RSV infection require hospitalization. The aim of this case is to reaffirm the importance of this virus as a cause of severe disease and to emphasize the importance of adequate diagnosis and management to improve prognosis. Clinical case: Child of 1 year 3 months old, without risk factors for severe infection by respiratory viruses...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905021/influenza-illness-averted-by-influenza-vaccination-among-school-year-children-in-beijing-2013-2016
#17
Yi Zhang, Zhidong Cao, Valentina Costantino, David J Muscatello, Abrar Ahmad Chughtai, Peng Yang, Quanyi Wang, C Raina MacIntyre
BACKGROUND: The benefit of school-based influenza vaccination policy has not been fully addressed in Beijing. OBJECTIVES: To evaluate the benefit of school-based influenza vaccination policy launched in Beijing. METHODS: Using existing surveillance and immunization data, we developed a dynamic transmission model to assess the impact of influenza vaccination in school-going children. The outcome was defined as the averted number of medically attended influenza illnesses and the prevented disease fraction to all children aged 5-14 years for the 2013/14, 2014/15, and 2015/16 seasons...
June 14, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29903376/burden-of-streptococcus-pneumoniae-and-haemophilus-influenzae-type-b-disease-in-children-in-the-era-of-conjugate-vaccines-global-regional-and-national-estimates-for-2000-15
#18
Brian Wahl, Katherine L O'Brien, Adena Greenbaum, Anwesha Majumder, Li Liu, Yue Chu, Ivana Lukšić, Harish Nair, David A McAllister, Harry Campbell, Igor Rudan, Robert Black, Maria Deloria Knoll
BACKGROUND: Pneumococcal conjugate vaccine (PCV) and Haemophilus influenzae type b (Hib) vaccine are now used in most countries. To monitor global and regional progress towards improving child health and to inform national policies for disease prevention and treatment, we prepared global, regional, and national disease burden estimates for these pathogens in children from 2000 to 2015. METHODS: Using WHO and Maternal and Child Epidemiology Estimation collaboration country-specific estimates of pneumonia and meningitis mortality and pneumonia morbidity from 2000 to 2015, we applied pneumococcal and Hib cause-specific proportions to estimate pathogen-specific deaths and cases...
July 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29902184/factors-associated-with-uptake-of-influenza-and-pertussis-vaccines-among-pregnant-women-in-south-australia
#19
Hassen Mohammed, Michelle Clarke, Ann Koehler, Maureen Watson, Helen Marshall
BACKGROUND: Maternal immunization is an effective strategy to protect pregnant women and their infants from vaccine-preventable diseases. Despite the recommendation of maternal influenza and more recently pertussis immunization in Australia, uptake of these vaccines has been suboptimal. A midwife delivered immunization program for pregnant women at the Women's and Children's Hospital in South Australia commenced in April 2015. Monitoring the uptake of the current funded vaccine programs for pregnant women is limited...
2018: PloS One
https://www.readbyqxmd.com/read/29901743/predictors-and-temporal-trend-of-flu-vaccination-in-auto-immune-rheumatic-diseases-in-the-uk-a-nationwide-prospective-cohort-study
#20
Georgina Nakafero, Matthew J Grainge, Puja R Myles, Christian D Mallen, Weiya Zhang, Michael Doherty, Jonathan S Nguyen-Van-Tam, Abhishek Abhishek
Objectives: To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. Methods: From the Clinical Practice Research Datalink, 32 751 people with auto-immune rheumatic diseases prescribed DMARDs between 2006 and 2016 were identified. The proportion vaccinated between 1 September of one year and 31 March of the next year was calculated and stratified by age, other indications for vaccination, auto-immune rheumatic diseases type and number of DMARDs prescribed...
June 12, 2018: Rheumatology
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