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International Medicine

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https://www.readbyqxmd.com/read/29792980/language-used-by-health-care-professionals-to-describe-dying-at-an-acute-care-hospital
#1
Kirsten Wentlandt, Philippe Toupin, Natalia Novosedlik, Lisa W Le, Camilla Zimmermann, Ebru Kaya
PURPOSE: To understand the language used to describe the deterioration and death of patients in an acute academic tertiary care centre, and to identify whether patient diagnoses or palliative care(PC) involvement was associated with clearer descriptions of this process. METHODS: We conducted a retrospective chart review of the final admission of 150 patients who died on an inpatient internal medicine unit. Conventional and summative content analysis was performed of the language used to describe, either directly or indirectly, that the patient's death was imminent...
May 21, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29792967/validated-reverse-phase-hplc-diode-array-method-for-the-quantification-of-intact-bevacizumab-infliximab-and-trastuzumab-for-long-term-stability-study
#2
Antonio Martínez-Ortega, Agustín Herrera, Antonio Salmerón-García, José Cabeza, Luis Cuadros-Rodríguez, Natalia Navas
The aim of the present study was to develop suitable and reliable method for quantification three of the most worldwide used therapeutic monoclonal antibodies (mAbs) -bevazizumab (BVZ), infliximab (INF) and trastuzumab (TTZ)- to be used in long-term stability studies. Reverse phase (RP) was selected by its greater sensibility and reproducibility comparing with other chromatographic modes. Then a high performance liquid chromatography with diode array detection (RP)HPLC/DAD method was checked. Since the three mAbs represent the active ingredient in the medicines in which they are formulated, the selected method was validated for each one in accordance with the International Conference on Harmonization (ICH) guidelines for pharmaceuticals for human use...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792672/biosynthesis-of-lincosamide-antibiotics-reactions-associated-with-degradation-and-detoxification-pathways-play-a-constructive-role
#3
Daozhong Zhang, Zhijun Tang, Wen Liu
Natural products typically are small molecules produced by living organisms. These products possess a wide variety of biological activities and thus have historically played a critical role in medicinal chemistry and chemical biology either as chemotherapeutic agents or as useful tools. Natural products are not synthesized for use by human beings; rather, living organisms produce them in response to various biochemical processes and environmental concerns, both internal and external. These processes/concerns are often dynamic and thus motivate the diversification, optimization, and selection of small molecules in line with changes in biological function...
May 24, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29792564/cognitive-and-behavioral-resilience-among-young-gay-and-bisexual-men-living-with-hiv
#4
Sophia A Hussen, Gary W Harper, Caryn R R Rodgers, Jacob J van den Berg, Nadia Dowshen, Lisa B Hightow-Weidman
PURPOSE: HIV/AIDS disproportionately affects young gay, bisexual, and other men who have sex with men (Y-GBMSM). Resilience remains understudied among Y-GBMSM living with HIV, but represents a potentially important framework for improving HIV-related outcomes in this population. We sought to explore cognitive and behavioral dimensions of resilience and their correlates among Y-GBMSM to gain insights to inform future interventions. METHODS: Our study sample consisted of 200 Y-GBMSM living with HIV enrolled in a multisite study of the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN)...
August 2017: LGBT Health
https://www.readbyqxmd.com/read/29792270/-biomarking-the-transition-from-genetic-risk-to-kidney-disease
#5
Etty Kruzel-Davila, Karl Skorecki
Only some individuals carrying the high-risk APOL1 genotype go on to develop kidney disease phenotypes. In this issue of Kidney International, Nadkarni and colleagues report the associations of several biomarkers with renal outcomes in individuals with high-risk APOL1 genotypes. In the era of precision medicine, these findings should translate into improved longitudinal risk assessment for this high-risk population and might also provide additional insights regarding sites and mechanisms of APOL1 nephropathy...
June 2018: Kidney International
https://www.readbyqxmd.com/read/29792193/research-ethics-review-at-university-eduardo-mondlane-uem-maputo-central-hospital-mozambique-2013-2016-a-descriptive-analysis-of-the-start-up-of-a-new-research-ethics-committee-rec
#6
Jahit Sacarlal, Vasco Muchanga, Carlos Mabutana, Matilde Mabui, Arlete Mariamo, Assa Júlio Cuamba, Leida Artur Fumo, Jacinta Silveira, Elizabeth Heitman, Troy D Moon
BACKGROUND: Mozambique has seen remarkable growth in biomedical research over the last decade. To meet a growing need, the National Committee for Bioethics in Health of Mozambique (CNBS) encouraged the development of ethical review processes at institutions that regularly conduct medical and social science research. In 2012, the Faculty of Medicine (FM) of University Eduardo Mondlane (UEM) and the Maputo Central Hospital (MCH) established a joint Institutional Committee on Bioethics for Health (CIBS FM & MCH)...
May 23, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29792142/collaboration-of-the-joint-research-centre-and-the-european-customs-laboratories-for-identification-of-new-psychoactive-substances
#7
Claude Guillou, Fabiano Reniero, Joana Lobo Pereira Vicente, Margaret Holland, Kamil Kolar, Hubert Chassaigne, Salvatore Tirendi, Herve Schepers
The emergence of designer drugs as substances of abuse has seen a dramatic increase over the last few years. Customs officials are responsible for the control of products entering the European Union (EU) market. This control applies to chemicals in general, pharmaceutical products and medicines. Numerous products imported from non-EU countries, often -declared as 'bath salts' or 'fertilizers', may in fact contain new psychoactive substance (NPS). These are not necessarily controlled under international law, but are subject to monitoring in agreement with EU legislation...
May 23, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29792102/entrusting-internal-medicine-residents-to-use-point-of-care-ultrasound-towards-improved-assessment-and-supervision
#8
Daniel J Schnobrich, Benji K Mathews, Bernard E Trappey, Brian K Muthyala, Andrew P J Olson
BACKGROUND: Internal medicine physicians and trainees are increasingly using, and seeking training in, diagnostic point of care ultrasound (POCUS). Numerous internal medicine training programs have described their curricula, but little has been written about how learners should be assessed, supervised, and allowed to progress toward independent practice, yet these practices are imperative for safe and effective use. Entrustable professional activities (EPAs) offer a practical method to assess observable units of professional work and make supervision decisions...
May 23, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29791822/extracorporeal-membrane-oxygenation-for-severe-acute-respiratory-distress-syndrome
#9
Alain Combes, David Hajage, Gilles Capellier, Alexandre Demoule, Sylvain Lavoué, Christophe Guervilly, Daniel Da Silva, Lara Zafrani, Patrice Tirot, Benoit Veber, Eric Maury, Bruno Levy, Yves Cohen, Christian Richard, Pierre Kalfon, Lila Bouadma, Hossein Mehdaoui, Gaëtan Beduneau, Guillaume Lebreton, Laurent Brochard, Niall D Ferguson, Eddy Fan, Arthur S Slutsky, Daniel Brodie, Alain Mercat
BACKGROUND: The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. METHODS: In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria - a ratio of partial pressure of arterial oxygen (Pao2 ) to the fraction of inspired oxygen (Fio2 ) of less than 50 mm Hg for more than 3 hours; a Pao2 :Fio2 of less than 80 mm Hg for more than 6 hours; or an arterial blood pH of less than 7...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791515/comparison-of-oscillometric-doppler-and-invasive-blood-pressure-measurement-in-anesthetized-goats
#10
Olga Szaluś-Jordanow, Michał Czopowicz, Agata Moroz, Marcin Mickiewicz, Magdalena Garncarz, Emilia Bagnicka, Tadeusz Frymus, Jarosław Kaba
Arterial blood pressure (BP) can be measured directly using an invasive intra-arterial method. This method is considered a gold standard, however it is potentially hazardous and requires expensive equipment and professional skills. Therefore, two non-invasive methods-Doppler ultrasonic sphygmomanometry and oscillometry-have been introduced in veterinary medicine. Their accuracy has so far been reliably evaluated in various animal species, however only one study included a small group of goats. Therefore, we carried out a large-scale study which aimed to evaluate agreement between the two non-invasive methods and invasive intra-arterial BP measurement in anesthetized goats at various age...
2018: PloS One
https://www.readbyqxmd.com/read/29791424/-primary-biliary-cholangitis-part-2-state-of-the-art-diagnosis-associated-diseases-treatment-and-prognosis
#11
Diego Andrés Rodríguez Lugo, Jorge Julián Coronado Tovar, Giovana Alejandra Solano Villamarin, Wiliam Otero Regino
Primary biliary cholangitis (PBC) is a chronic autoimmune cholangiopathy characterized by a selective destruction of biliary epithelial cells of small and medium caliber hepatic ducts, which mainly affects women. The main symptoms are fatigue and pruritus, however, a large proportion of patients may be asymptomatic. The diagnosis is based on AMA titers >1:40, alkaline phosphatase >1.5 times the upper limit for more than 24 weeks and compatible liver histology. It is associated with multiple autoimmune diseases mainly extrahepatic, thyroid diseases, bone diseases, among others...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29791319/malignancy-in-a-retrospective-cohort-of-17-patients-with-dermatomyositis-or-polymyositis-in-southern-tunisia
#12
Khadija Sellami, Madiha Mseddi, Mouna Snoussi, Hela Gharbi, Faten Frikha, Rayda Ben Salah, Moez Jallouli, Sameh Marzouk, Abderrahmen Masmoudi, Zouhir Bahloul, Hamida Turki
INTRODUCTION: The prognosis of dermatomyositis (DM)/polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. METHODS: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015...
May 21, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29791173/-rotational-thromboelastometry-in-therapy-of-life-threatening-bleeding
#13
Miroslav Durila
Bleeding and coagulopathy is a common problem in the fields of internal medicine. In case of life-threatening bleeding, rotational thromboelastometry (ROTEM) has critical role in diagnosis and therapy of coagulopathy. In contrast to commonly used tests such as prothrombin time and activated partial thromboplastin time, ROTEM evaluates coagulation of the whole blood as a bedside method. The use of ROTEM for rapid diagnosis and targeted therapy of coagulopathy leads to reduction in bleeding and thus to reduction in administration of blood transfusion products...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790923/missed-opportunities-to-prescribe-preexposure-prophylaxis-in-south-carolina-2013-2016
#14
Dawn K Smith, Man-Huei Chang, Wayne A Duffus, Stella Okoye, Sharon Weissman
Introduction: Expanding use of preexposure prophylaxis (PrEP) in ways that address current racial/ethnic disparities is an important HIV prevention goal. We investigated missed opportunities to provide PrEP during healthcare visits occurring prior to HIV infection. Methods: This retrospective cohort study linked South Carolina HIV case surveillance data to 3 statewide healthcare databases. Characteristics of patients, health care visits and providers, sexually transmitted diseases (STD), and other diagnoses, were assessed for medical encounters occurring before an initial HIV diagnosis...
May 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29790516/ultrafast-excited-state-decay-of-natural-uv-filters-from-intermolecular-hydrogen-bonds-to-a-conical-intersection
#15
Peter S Sherin, Yuri P Tsentalovich, Eric Vauthey, Enrico Benassi
Kynurenines (KNs) are natural UV filters of the human eye lens, protecting the eye tissues from solar UV radiation. Key points of their effective protection are the intramolecular charge transfer (ICT) in the excited state and the fast dissipation of absorbed light energy into heat via the intermolecular H-bonds. Herein we report that the introduction of an unsaturated double bond in the amino acid side chain, operating as an ICT-enhancing electron donor group, drastically accelerates the internal conversion (IC) due to a conical intersection (CI) between the potential energy surfaces of the excited and ground states...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29790405/poor-medication-adherence-in-patients-with-psoriasis-and-a-successful-intervention
#16
Wei Wang, Ying Qiu, Fengying Zhao, Furen Zhang
BACKGROUND: The medication adherence of psoriasis patients may be influenced by a series combined internal and external factors. Effective methods for improving adherence could improve treatment outcomes. OBJECTIVE: To characterize medication adherence in psoriasis patients in China and to test an intervention to improve psoriasis patients' adherence. METHODS: We investigated 200 patients with psoriasis using questionnaires to determine their medication adherence and the factors that influence adherence...
May 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29790218/lost-in-transition-finding-a-path-forward-for-young-adults-with-type-1-diabetes
#17
L Laffel
In this issue of Diabetic Medicine, Kellett and colleagues describe the experiences of young persons with Type 1 diabetes in the UK as their needs and self-care efforts for diabetes management evolve during the university years [1]. In the 21st century, the topic of transitions in care for young people with various chronic diseases, in general, and with Type 1 diabetes, in particular, has become a popular and appealing area for cross-sectional, observational and interventional research globally [2]. Similarly, a number of national and international organizations have published clinical guidelines related to transition, although many of the clinical recommendations are based upon expert consensus rather than empirical data [3-7]...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790072/effect-of-social-comparison-feedback-on-laboratory-test-ordering-for-hospitalized-patients-a-randomized-controlled-trial
#18
Kira Ryskina, C Jessica Dine, Yevgeniy Gitelman, Damien Leri, Mitesh Patel, Gregory Kurtzman, Lisa Y Lin, Andrew J Epstein
BACKGROUND: Social comparison feedback is an increasingly popular strategy that uses performance report cards to modify physician behavior. Our objective was to test the effect of such feedback on the ordering of routine laboratory tests for hospitalized patients, a practice considered overused. METHODS: This was a single-blinded randomized controlled trial. Between January and June 2016, physicians on six general medicine teams at the Hospital of the University of Pennsylvania were cluster randomized with equal allocation to two arms: (1) those e-mailed a summary of their routine laboratory test ordering vs...
May 22, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29789303/-me_who-anatomy-of-scholastic-leadership-and-social-isolation-of-underrepresented-minority-women-in-academic-medicine
#19
Michelle A Albert
In academic medicine, under-represented minority women physician-scientists (URMWP)* are uncommon, particularly in leadership positions. Data from the American Association of Medical Colleges (AAMC) show that among internal medicine chairs, there are 12 Asian males, 10 African/American (blacks; 9 men), 7 Hispanics (2 females) and 137 whites (21 females). In the top 40 ranked cardiology programs, there are no female cardiology chiefs, whereas there are at least 10, 2, 1 and 24 Asian, black, Hispanic and white males respectively...
May 22, 2018: Circulation
https://www.readbyqxmd.com/read/29789183/-do-not-do-recommendations-of-the-working-groups-of-the-spanish-society-of-intensive-and-critical-care-medicine-and-coronary-units-semicyuc-for-the-management-of-critically-ill-patients
#20
F J González de Molina Ortiz, F Gordó Vidal, A Estella García, P Morrondo Valdeolmillos, J F Fernández Ortega, J Caballero López, P V Pérez Villares, M A Ballesteros Sanz, C de Haro López, J A Sanchez-Izquierdo Riera, A Serrano Lázaro, M P Fuset Cabanes, L J Terceros Almanza, X Nuvials Casals, J Baldirà Martínez de Irujo
The project "Commitment to Quality of Scientific Societies", promoted since 2013 by the Spanish Ministry of Health, seeks to reduce unnecessary health interventions that have not proven effective, have little or doubtful effectiveness, or are not cost-effective. The objective is to establish the "do not do" recommendations for the management of critically ill patients. A panel of experts from the 13 working groups (WGs) of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) was selected and nominated by virtue of clinical expertise and/or scientific experience to carry out the recommendations...
May 19, 2018: Medicina Intensiva
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