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https://www.readbyqxmd.com/read/29334348/assessing-the-readiness-of-precision-medicine-interoperabilty-an-exploratory-study-of-the-national-institutes-of-health-genetic-testing-registry
#1
Jay G Ronquillo, Chunhua Weng, William T Lester
BACKGROUND:   Precision medicine involves three major innovations currently taking place in healthcare:  electronic health records, genomics, and big data.  A major challenge for healthcare providers, however, is understanding the readiness for practical application of initiatives like precision medicine. OBJECTIVE:   To better understand the current state and challenges of precision medicine interoperability using a national genetic testing registry as a starting point, placed in the context of established interoperability formats...
November 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29334141/characterization-of-macromolecular-baseline-of-human-brain-using-metabolite-cycled-semi-laser-at-9-4t
#2
Ioannis-Angelos Giapitzakis, Nikolai Avdievich, Anke Henning
PURPOSE: Macromolecular resonances (MM) arise mainly from cytosolic proteins and overlap with metabolites, influencing metabolite quantification. Macromolecules can serve as valuable biomarkers for diseases and pathologies. The objectives of this study were to characterize MM at 9.4T in the human brain (occipital and left parietal lobe) and to describe the RF coil setup used for MM acquisition in the two regions. METHODS: An adiabatic inversion pulse was optimised for metabolite nulling at 9...
January 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29334139/interleaved-susceptibility-weighted-and-flair-mri-for-imaging-lesion-penetrating-veins-in-multiple-sclerosis
#3
Refaat E Gabr, Amol S Pednekar, Arash Kamali, John A Lincoln, Flavia M Nelson, Jerry S Wolinsky, Ponnada A Narayana
PURPOSE: To simultaneously image brain lesions and veins in multiple sclerosis. METHODS: An interleaved sequence was developed to simultaneously acquire 3-dimensional T2*-weighted (or susceptibility-weighted (SW)) and fluid-attenuated inversion recovery (FLAIR) images on a 3T MRI system. The pulse sequence parameters were calculated to minimize signal perturbation from steady state while maintaining acceptable image contrast and scan time. Fifteen multiple sclerosis patients were enrolled in this prospective study and underwent a standard multiple sclerosis imaging protocol...
January 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29334131/a-bayesian-method-for-accelerated-magnetic-resonance-elastography-of-the-liver
#4
Christopher Ebersole, Rizwan Ahmad, Adam V Rich, Lee C Potter, Huiming Dong, Arunark Kolipaka
PURPOSE: Magnetic resonance elastography is a noninvasive tool for quantifying soft tissue stiffness. Magnetic resonance elastography has been adopted as a clinical method for staging liver fibrosis. However, the application of liver magnetic resonance elastography requires multiple lengthy breath-holds. We propose a new data acquisition and processing method to reduce magnetic resonance elastography scan time. METHODS: A Bayesian image reconstruction method that uses transform sparsity and magnitude consistency across different phase offsets to recover images from highly undersampled data is proposed...
January 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29334128/improved-liver-r2-mapping-by-pixel-wise-curve-fitting-with-adaptive-neighborhood-regularization
#5
Changqing Wang, Xinyuan Zhang, Xiaoyun Liu, Taigang He, Wufan Chen, Qianjin Feng, Yanqiu Feng
PURPOSE: To improve liver R2* mapping by incorporating adaptive neighborhood regularization into pixel-wise curve fitting. METHODS: Magnetic resonance imaging R2* mapping remains challenging because of the serial images with low signal-to-noise ratio. In this study, we proposed to exploit the neighboring pixels as regularization terms and adaptively determine the regularization parameters according to the interpixel signal similarity. The proposed algorithm, called the pixel-wise curve fitting with adaptive neighborhood regularization (PCANR), was compared with the conventional nonlinear least squares (NLS) and nonlocal means filter-based NLS algorithms on simulated, phantom, and in vivo data...
January 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29333565/manual-on-the-proper-use-of-lutetium-177-labeled-somatostatin-analogue-lu-177-dota-tate-injectable-in-radionuclide-therapy-2nd-ed
#6
Makoto Hosono, Hideharu Ikebuchi, Yoshihide Nakamura, Nobutaka Nakamura, Takahiro Yamada, Sachiko Yanagida, Asami Kitaoka, Kiyotaka Kojima, Hiroyasu Sugano, Seigo Kinuya, Tomio Inoue, Jun Hatazawa
Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. This guideline was prepared by a study supported by Ministry of Health, Labour, and Welfare, and approved by Japanese Society of Nuclear Medicine. Lu-177-DOTA-TATE treatment in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown in this guideline are considered internationally useful as well...
January 15, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29333470/history-and-perspectives-of-nuclear-medicine-in-myanmar
#7
Win Mar
Nuclear Medicine was established in Myanmar in 1963 by Dr Soe Myint and International Atomic Energy expert Dr R. Hochel at Yangon General Hospital. Nuclear medicine diagnostic and therapeutic services started with Probe Scintillation Detector Systems and rectilinear scanner. In the early stage, many Nuclear Medicine specialists from the International Atomic Energy Agency (IAEA) spent some time in Myanmar and made significant contributions to the development of Nuclear Medicine in our country. The department participated in various IAEA technical cooperation projects and regional cooperation projects...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333463/characteristics-of-smoothing-filters-to-achieve-the-guideline-recommended-positron-emission-tomography-image-without-harmonization
#8
Yuji Tsutsui, Shinichi Awamoto, Kazuhiko Himuro, Yoshiyuki Umezu, Shingo Baba, Masayuki Sasaki
Objectives: The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was filled with 18F solution with a background activity of 2.65 kBq/mL and a sphere-to-background ratio of 4...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333143/task-force-on-ckd-we-have-come-a-long-way
#9
Graham R D Jones
Chronic Kidney Disease (CKD) is an important medical condition where diagnosis, staging and monitoring is largely based on routine laboratory tests. During the last 15 years there have been many important changes in the clinical management of CKD described in key international guidelines. In order to successfully implement these guidelines, laboratories must collaborate with clinicians to provide a co-ordinated service, including accurate measurements and of creatinine and urine albumin and reporting of an estimated glomerular filtration rate (eGFR)...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333039/pharmacognostic-assesment-of-the-endemic-and-vulnerable-medicinal-climber-cayratia-pedata-lam-gagnep-var-glabra-gamble-and-its-antibacterial-activity
#10
S Sharmila, K Kalaichelvi, S M Dhivya, P Premamalini, P Abirami, G Jayanthi
Objective: The objective of this study is to evaluate a meticulous pharmacognostic cram is to supplement constructive information with regard to its identification, characterization, and standardization of endemic and endangered medicinal climber Cayratia pedata var. glabra and also screening the antibacterial activity of this climber. Materials and Methods: The morphological characters of study plant, microscopic examination of leaf powder, anatomy of young stem, physicochemical analysis of plant powder, extractive values, phytochemical analysis, powder with different chemical reagents, fluorescence analysis of plant powder, and other World Health Organization (WHO) recommended for standardization were analyzed...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332500/microstructure-and-mechanical-properties-of-porous-titanium-structures-fabricated-by-electron-beam-melting-for-cranial-implants
#11
Khaja Moiduddin
The traditional methods of metallic bone implants are often dense and suffer from adverse reactions, biomechanical mismatch and lack of adequate space for new bone tissue to grow into the implant. The objective of this study is to evaluate the customized porous cranial implant with mechanical properties closer to that of bone and to improve the aesthetic outcome in cranial surgery with precision fitting for a better quality of life. Two custom cranial implants (bulk and porous) are digitally designed based on the Digital Imaging and Communications in Medicine files and fabricated using additive manufacturing...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29331970/is-there-a-social-gradient-of-sarcopenia-a-meta-analysis-and-systematic-review-protocol
#12
Darci Green, Gustavo Duque, Nick Fredman, Aoun Rizvi, Sharon Lee Brennan-Olsen
INTRODUCTION: Sarcopenia (or loss of muscle mass and function) is a relatively new area within the field of musculoskeletal research and medicine. Investigating whether there is a social gradient, including occupation type and income level, of sarcopenia, as observed for other diseases, will contribute significantly to the limited evidence base for this disease. This new information may inform the prevention and management of sarcopenia and widen the evidence base to support existing and future health campaigns...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331950/construction-of-an-evaluation-index-system-for-determining-the-academic-impact-of-military-medical-scholars
#13
Xuan Li, J Y Hao
INTRODUCTION: Academic papers are an essential manner for describing new ideas and consolidating existing concepts in the field of military medicine. The academic impact of military medical publications reflects the extent and depth of recognition, acceptance and utilisation of the concepts transmitted in these publications. The aim of this research was to construct an evaluation index system suitable for evaluating the academic influence of scholars in the field of military medicine...
January 13, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#14
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330715/case-series-analysis-of-new-zealand-reports-of-rapid-intense-potentiation-of-warfarin-by-roxithromycin
#15
Ruth L Savage, Michael V Tatley
INTRODUCTION: We undertook an analysis of all the reports to the New Zealand Centre for Adverse Reactions Monitoring of a roxithromycin/warfarin interaction after two recent reports described intense rapid warfarin potentiation. The interaction was first published in 1995. Cytochrome P450 3A4 inhibition has been the proposed mechanism but has limited biologic plausibility. There are suggestions that the clinical significance of the interaction may be increased by severe illness, polypharmacy, renal dysfunction, older age and increased warfarin sensitivity...
January 12, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29330235/primary-care-physician-perspectives-about-antipsychotics-and-other-medications-for-symptoms-of-dementia
#16
J William Kerns, Jonathan D Winter, Katherine M Winter, Terry Boyd, Rebecca S Etz
BACKGROUND: Guidelines, policies, and warnings have been applied to reduce the use of medications for behavioral and psychological symptoms of dementia (BPSD). Because of rare dangerous side effects, antipsychotics have been singled out in these efforts. However, antipsychotics are still prescribed "off label" to hundreds of thousands of seniors residing in nursing homes and communities. Our objective was to evaluate how and why primary-care physicians (PCPs) employ nonpharmacologic strategies and drugs for BPSD...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330232/interventions-must-be-realistic-to-be-useful-and-completed-in-family-medicine
#17
EDITORIAL
Marjorie A Bowman, Dean A Seehusen, Anne Victoria Neale
Being realistic while helping our patients is this issue's theme. Given the volume of tasks required in family medicine, recommendations for improvements in direct care or care measurement cannot just be evidence-based but must also be realistic. On the list of realistic: ordering antipsychotics for symptoms of dementia in the elderly, despite recommendations to not do so; ordering antidepressants without fear that the patient could develop hypertension; mental health care providers in primary care offices; forced choice for opioid management; plus agenda setting for visit efficiency...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330175/development-and-validation-of-an-instrument-for-measuring-the-burden-of-medicine-on-functioning-and-well-being-the-medication-related-burden-quality-of-life-mrb-qol-tool
#18
Mohammed A Mohammed, Rebekah J Moles, Sarah N Hilmer, Lisa Kouladjian O'Donnel, Timothy F Chen
OBJECTIVE: Medication-related burden (MRB) is a negative experience with medicine, which may impact on psychological, social, physical and financial well-being of an individual. This study describes the development and initial validation of an instrument specifically designed to measure MRB on functioning and well-being-the Medication-Related Burden Quality of Life (MRB-QoL) tool. METHODS: An initial pool of 76-items for MRB-QoL was generated. The link to MRB-QoL survey was sent to a sample of consumers living with at least one chronic medical condition and taking ≥3 prescription medicines on a regular basis...
January 11, 2018: BMJ Open
https://www.readbyqxmd.com/read/29329993/pulmonary-arterial-hypertension-in-four-patients-treated-by-leflunomide
#19
Valentin Coirier, Alain Lescoat, Céline Chabanne, Maxime Fournet, Guillaume Coiffier, Stéphane Jouneau, Elisabeth Polard, Patrick Jégo
Pulmonary arterial hypertension (PAH) is a rare disorder that can be drug-induced, mostly following treatment by appetite-suppressant drugs. We report four cases of patients who developed PAH following a treatment by leflunomide for rheumatoid arthritis, psoriatic arthritis or undetermined connective tissue disease. All patients described a progressive dyspnea from grade II to IV of NYHA classification; clinical examination found signs of heart failure. PAH was finally diagnosed and confirmed by right heart catheterisation...
January 9, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29329525/reporting-of-heterogeneity-of-treatment-effect-in-cohort-studies-a-review-of-the-literature
#20
Meryl Dahan, Caroline Scemama, Raphael Porcher, David J Biau
BACKGROUND: This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis. METHODS: prospective cohort studies, in English language, measuring the effect of a treatment (pharmacological, interventional, or other) published among 119 core clinical journals (defined by the National Library of Medicine) in the last 16 years were selected in the following data source: Medline...
January 12, 2018: BMC Medical Research Methodology
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