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https://www.readbyqxmd.com/read/29785790/the-role-of-mirna-regulation-in-fetal-cardiomyocytes-cardiac-maturation-and-the-risk-of-heart-disease-in-adults
#1
Mitchell C Lock, Ross L Tellam, Kimberley J Botting, Kimberley C W Wang, Joseph B Selvanayagam, Doug A Brooks, Mike Seed, Janna L Morrison
Myocardial infarction is a primary contributor towards the global burden of cardiovascular disease. Rather than repairing the existing damage of myocardial infarction, current treatments only address the symptoms of the disease and reducing the risk of a secondary infarction. Cardiac regenerative capacity is dependent on cardiomyocyte proliferation, which concludes soon after birth in humans and precocial species such as sheep. Human fetal cardiac tissue has some ability to repair following tissue damage, whereas a fully matured human heart has minimal capacity for cellular regeneration...
May 22, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29781990/fetal-mouse-cardiovascular-imaging-using-a-high-frequency-ultrasound-30-45mhz-system
#2
Marlin Touma
Congenital heart defects (CHDs) are the most common cause of childhood morbidity and early mortality. Prenatal detection of the underlying molecular mechanisms of CHDs is crucial for inventing new preventive and therapeutic strategies. Mutant mouse models are powerful tools to discover new mechanisms and environmental stress modifiers that drive cardiac development and their potential alteration in CHDs. However, efforts to establish the causality of these putative contributors have been limited to histological and molecular studies in non-survival animal experiments, in which monitoring the key physiological and hemodynamic parameters is often absent...
May 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781091/fetal-assessment-in-buprenorphine-maintained-women-using-fetal-magnetoencephalography-a-pilot-study
#3
Diana Escalona-Vargas, Jessica L Coker, Shona Ray-Griffith, Eric R Siegel, Curtis L Lowery, Zachary N Stowe, Hari Eswaran
BACKGROUND AND AIMS: In-utero exposure to opioids including buprenorphine (BUP) has been shown to affect fetal activity, specifically heart-rate variability (FHRV) and fetal movement (FM). Our objective was to extract simultaneous recordings of fetal cardiac, and brain-related activity in BUP-maintained and non-opioid exposed pregnant women using a novel non-invasive biomagnetic technique. DESIGN: A pilot study was conducted, recording and analyzing biomagnetic data from fetuses of BUP-maintained and non-opioid exposed pregnant women...
May 20, 2018: Addiction
https://www.readbyqxmd.com/read/29781076/first-trimester-combined-screening-for-fetal-aneuploidies-enhanced-with-additional-ultrasound-markers-an-8-year-prospective-study
#4
Dragos Nemescu, Adina Bratie, Alexandra Mihaila, Dan Navolan, Adina Tanase
OBJECTIVES: To describe our screening population and audit of the performance of first-trimester screening for Down syndrome, based on a combined test, enhanced with additional ultrasound markers, over the whole period of the study. MATERIAL AND METHODS: We performed a prospective study from 2009 to 2016, which included 1358 singleton fetuses with a crown-rump length of 45-84 mm. The risk of aneuploidy was calculated using nuchal translucency, fetal heart rate (FHR), and additional markers, such as nasal bone (NB), tricuspid flow (TF) and ductus venosus (DV), combined with maternal serum free β-human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A)...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29779390/-prenatally-diagnosed-case-of-pallister%C3%A2-killian-syndrome
#5
Zsolt Tidrenczel, Erika P Tardy, Edina Sarkadi, Judit Simon, Artúr Beke, János Demeter
Pallister-Killian syndrome (PKS) is a rare, sporadic genetic disorder that is caused by the mosaic presence of a supernumerary marker chromosome, isochromosome 12p. The syndrome is a polydysmorphic condition characterized by mental retardation, craniofacial dysmorphism, hypotonia, seizures, epilepsy and certain organic malformations (diaphragmatic hernia, congenital heart disease). Prenatal diagnosis is challenging due to the mosaic tissue-specific distribution of the chromosomal disorder and highly variable phenotype...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29777898/a-survey-of-health-professionals-views-on-acceptable-gestational-age-and-termination-of-pregnancy-for-fetal-anomaly
#6
Lisa Crowe, Ruth H Graham, Stephen C Robson, Judith Rankin
Termination of pregnancy for fetal anomaly is legal in the UK with no upper limit, if two doctors, in good faith, agree "there is a substantial risk that if the child were born it would suffer from such physical or mental abnormalities as to be seriously handicapped". This is Clause E of the Human Fertlisation and Embryology Act. The most commonly sighted Clause is C, which states "the pregnancy has not exceeded its twenty-fourth week and that the continuance of the pregnancy would involve risk, greater than if the pregnancy were terminated, of injury to the physical or mental health of the pregnant woman"...
May 16, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29772030/correction-gestational-dietary-protein-is-associated-with-sex-specific-decrease-in-blood-flow-fetal-heart-growth-and-post-natal-blood-pressure-of-progeny
#7
Juan H Hernandez-Medrano, Katrina J Copping, Andrew Hoare, Wendela Wapanaar, Rosalie Grivell, Tim Kuchel, Giuliana Miguel-Pacheco, I Caroline McMillen, Raymond J Rodgers, Viv E A Perry
[This corrects the article DOI: 10.1371/journal.pone.0125694.].
2018: PloS One
https://www.readbyqxmd.com/read/29768964/effects-of-combined-spinal-epidural-analgesia-on-first-stage-of-labor-a-cohort-study
#8
Silvia Poma, Luigia Scudeller, Chiara Verga, Giorgio Mirabile, Barbara Gardella, Federica Broglia, Maria Ciceri, Marinella Fuardo, Simona Pellicori, Maddalena Gerletti, Silvia Zizzi, Elena Masserini, Maria Paola Delmonte, Giorgio Antonio Iotti
BACKGROUND: Neuraxial anesthesia is considered as the gold standard in the control labor of pain. Its variants are epidural analgesia and combined spinal-epidural analgesia. Few studies, as yet, have investigated the duration of labor as a primary outcome. Some authors have suggested that combined spinal-epidural analgesia may reduce labor duration but at the moment the benefit of shortening labor is uncertain. The main aim of this study was to compare combined spinal-epidural with epidural analgesia in terms of their effect on duration of stage I labor, maternal, and neonatal outcomes...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29768660/validation-of-a-computerized-algorithm-to-quantify-fetal-heart-rate-deceleration-area
#9
Erika Gyllencreutz, Ke Lu, Kaj Lindecrantz, Pelle G Lindqvist, Lennart Nordstrom, Malin Holzmann, Farhad Abtahi
INTRODUCTION: Reliability in visual cardiotocography interpretation is unsatisfying, which has led to development of computerized cardiotocography. Computerized analysis is well established for antenatal fetal surveillance, but has yet not performed sufficiently during labor. We aimed to investigate the capacity of a new computerized algorithm compared to visual assessment in identifying intrapartum fetal heart rate baseline and decelerations. MATERIAL AND METHODS: Three-hundred-and-twelve intrapartum cardiotocography tracings with variable decelerations were analysed by the computerized algorithm and visually examined by two observers, blinded to each other and the computer analysis...
May 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29762460/a-new-life-motherhood-after-heart-transplantation-a-single-center-experience-and-review-of-literature
#10
Francesca Macera, Lucia Occhi, Gabriella Masciocco, Marisa Varrenti, Maria Frigerio
BACKGROUND: Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks, and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy in order to minimize risks for both the mother and the fetus. METHOD: We describe our experience with 12 pregnancies occurred in 11 women who had undergone HTx at our center...
May 14, 2018: Transplantation
https://www.readbyqxmd.com/read/29761681/milestones-in-the-development-of-fetal-cardiac-interventions
#11
REVIEW
Edward G Abinader
Cardiac patients of all ages were managed in the past by internists who specialized in cardiology. During the past 50 years, the medical field has witnessed great strides in the management of congenital heart disease, and thus pediatric cardiology has become a subspecialty in many countries. This review article focuses on the advances in fetal cardiac interventions (FCI) since its inception by our group in 1975. Three major modes of FCI have evolved during the past 42 years: pharmacologic, closed FCI, and open FCI...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29761627/muscle-fiber-type-diversity-revealed-by-anti-myosin-heavy-chain-antibodies
#12
REVIEW
Stefano Schiaffino
Different forms of myosin heavy chains (MyHCs), coded by a large family of sarcomeric MYH genes, are expressed in striated muscles. The generation of specific anti-MyHC antibodies has provided a powerful tool to define the fiber types present in skeletal muscles, their functional properties, their response to conditions that affect muscle plasticity and their changes in muscle disorders. Cardiomyocyte heterogeneity has been revealed by the serendipitous observation that different MyHCs are present in atrial and ventricular myocardium and in heart conduction tissue...
May 14, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29760728/mesenchymal-stromal-cells-cultured-in-serum-from-heart-failure-patients-are-more-resistant-to-simulated-chronic-and-acute-stress
#13
Timo Z Nazari-Shafti, Zhiyi Xu, Andreas Matthäus Bader, Georg Henke, Kristin Klose, Volkmar Falk, Christof Stamm
Despite regulatory issues surrounding the use of animal-derived cell culture supplements, most clinical cardiac cell therapy trials using mesenchymal stromal cells (MSCs) still rely on fetal bovine serum (FBS) for cell expansion before transplantation. We sought to investigate the effect of human serum from heart failure patients (HFS) on cord blood MSCs (CB-MSCs) during short-term culture under regular conditions and during simulated acute and chronic stress. Cell survival, proliferation, metabolic activity, and apoptosis were quantified, and gene expression profiles of selected apoptosis and cell cycle regulators were determined...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29758955/fetal-heart-rate-monitoring-device-using-condenser-microphone-sensor-validation-and-comparison-to-standard-devices
#14
Husna Azyan Binti Ahmad, Ismail M El-Badawy, Om Prakash Singh, Rozana Binti Hisham, M B Malarvili
BACKGROUND: Fetal heart rate (FHR) monitoring device is highly demanded to assess the fetus health condition in home environments. Conventional standard devices such as ultrasonography and cardiotocography are expensive, bulky and uncomfortable and consequently not suitable for long-term monitoring. Herein, we report a device that can be used to measure fetal heart rate in clinical and home environments. METHODS: The proposed device measures and displays the FHR on a screen liquid crystal display (LCD)...
April 27, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29758458/effects-of-maternal-nutrient-restriction-followed-by-realimentation-during-early-and-mid-gestation-in-beef-cows-ii-placental-development-umbilical-blood-flow-and-uterine-blood-flow-responses-to-diet-alterations
#15
L E Camacho, C O Lemley, S T Dorsam, K C Swanson, K A Vonnahme
The objectives were to examine the effects of maternal nutrient restriction followed by realimentation during early to mid-gestation on placental development and uterine and umbilical hemodynamics in the beef cow. On day 30 of pregnancy, multiparous, non-lactating beef cows (620.5 ± 11.3 kg) were assigned to 1 of 2 dietary treatments: control (C; 100% National Research Council [NRC] recommendations; n = 18) and restricted (R; 60% NRC; n = 30). On day 85, cows were slaughtered (C, n = 6; R, n = 6), remained on control (CC; n = 12) and restricted (RR; n = 12), or were realimented to control (RC; n = 11)...
April 24, 2018: Theriogenology
https://www.readbyqxmd.com/read/29757271/the-isolation-and-culture-of-primary-epicardial-cells-derived-from-human-adult-and-fetal-heart-specimens
#16
Esther Dronkers, Asja T Moerkamp, Tessa van Herwaarden, Marie-José Goumans, Anke M Smits
The epicardium, an epithelial cell layer covering the myocardium, has an essential role during cardiac development, as well as in the repair response of the heart after ischemic injury. When activated, epicardial cells undergo a process known as epithelial to mesenchymal transition (EMT) to provide cells to the regenerating myocardium. Furthermore, the epicardium contributes via secretion of essential paracrine factors. To fully appreciate the regenerative potential of the epicardium, a human cell model is required...
April 24, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29756643/isolated-premature-restriction-or-closure-of-foramen-ovale-in-fetuses-echocardiographic-characteristics-and-outcome
#17
Xiaoyan Gu, Ye Zhang, Jiancheng Han, Xiaowei Liu, Shuping Ge, Yihua He
BACKGROUND: Premature restriction or closure of foramen ovale (FO) in otherwise structurally normal hearts may be associated with right ventricular dilation, tricuspid regurgitation, pericardial effusion, heart failure, even poor perinatal outcomes. Data about these rare conditions are lacking. METHODS: We retrospectively reviewed the echocardiographic records of 9704 fetuses seen from 2010 to 2014 in Beijing Anzhen Hospital, a regional and national referral center, to ascertain the presence of restriction or closure of FO...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29756160/fetal-and-postnatal-echocardiographic-diagnosis-of-ebstein-anomaly-of-the-mitral-valve
#18
Safwat Aly, John Bokowski, Karim Diab, Brie Ann Muller
Ebstein anomaly of mitral valve (MV) is an extremely rare congenital heart disease. In the current report, we present a case of Ebstein of MV that was diagnosed prenatally. Fetal echocardiogram showed that the posterior leaflet of MV was tethered to the lateral wall of left ventricle (LV) with downward displacement into LV cavity. Postnatal transthoracic and transesophageal echocardiograms confirmed the diagnosis with apical displacement of the level of coaptation MV into the LV cavity. To the best of our knowledge, fetal diagnosis of Ebstein anomaly of MV has not yet been reported in the medical literature...
May 14, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29755962/acceptability-of-bedside-resuscitation-with-intact-umbilical-cord-to-clinicians-and-patients-families-in-the-united-states
#19
Anup C Katheria, Samuel R Sorkhi, Kasim Hassen, Arij Faksh, Zahra Ghorishi, Debra Poeltler
Background: While delayed umbilical cord clamping in preterm infants has shown to improve long-term neurological outcomes, infants who are thought to need resuscitation do not receive delayed cord clamping even though they may benefit the most. A mobile resuscitation platform allows infants to be resuscitated at the mother's bedside with the cord intact. The newborn is supplied with placental blood during the resuscitation in view of the mother. The objective of the study is to assess the usability and acceptability of mobile resuscitation platform, LifeStart trolley, among the infants' parents and perinatal providers...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29754451/maternal-exercise-season-and-sex-modify-the-human-fetal-circadian-rhythm
#20
Julie Sletten, Germaine Cornelissen, Jørg Assmus, Torvid Kiserud, Susanne Albrechtsen, Jörg Kessler
AIM: The knowledge on circadian rhythmicity is rapidly expanding. We aimed to define the longitudinal development of the circadian heart rate rhythm in the human fetus in an unrestricted, out-of-hospital setting, and to examine the effects of maternal physical activity, season and fetal sex. METHODS: We recruited 48 women with low-risk singleton pregnancies. Using a portable monitor for continuous fetal electrocardiography, fetal heart rate recordings were obtained around gestational weeks 24, 28, 32 and 36...
May 13, 2018: Acta Physiologica
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