Daphne Alcalá-Zúniga, Erika Espinoza-Torres, Ranjit Kumar Das, Magaly Vargas, Oscar Maldonado, Omar Benavides, Arvind Manojkumar, Roberto de la Garza, Natalia Davila, Isaac Perez, Alejandro Hernandez Martinez, Deepa Roy, Alejandro López-Juárez, Masoud M Zarei, Kelsey A Baker, Mario Gil, Hansapani Rodrigo, Gabriel A de Erausquin, Upal Roy
Parkinson's disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD...
February 13, 2024: Molecular Neurobiology