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https://www.readbyqxmd.com/read/28456020/deep-sequencing-of-h7n8-avian-influenza-viruses-from-surveillance-zone-supports-h7n8-high-pathogenicity-avian-influenza-was-limited-to-a-single-outbreak-farm-in-indiana-during-2016
#1
Dong-Hun Lee, Mia Kim Torchetti, Mary Lea Killian, David E Swayne
In mid-January 2016, an outbreak of H7N8 high-pathogenicity avian influenza virus (HPAIV) in commercial turkeys occurred in Indiana. Surveillance within the 10km control zone identified H7N8 low-pathogenicity avian influenza virus (LPAIV) in nine surrounding turkey flocks but no other HPAIV-affected premises. We sequenced four of the H7N8 HPAIV isolated from the single farm and nine LPAIV identified during control zone surveillance. Evaluation included phylogenetic network analysis indicating close relatedness across the HPAIV and LPAIV, and that the progenitor H7N8 LPAIV spread among the affected turkey farms in Indiana, followed by spontaneous mutation to HPAIV on a single premise through acquisition of three basic amino acids at the hemagglutinin cleavage site...
April 26, 2017: Virology
https://www.readbyqxmd.com/read/28455649/human-parainfluenza-virus-type-2%C3%A2-v-protein-inhibits-induction-of-tetherin
#2
Keisuke Ohta, Yusuke Matsumoto, Natsuko Yumine, Machiko Nishio
Tetherin is an anti-viral factor that restricts viral budding through tethering virions to the cell surface. The human parainfluenza virus type 2 (hPIV-2) V protein decreases cell surface tetherin in HeLa cells, which constitutively express endogenous tetherin. However, the role of the hPIV-2 V protein in tetherin induction remains unclear. Here, we examined whether hPIV-2 infection itself induces tetherin in HEK293 cells that have no basal expression of tetherin. Unlike influenza A virus (IAV) infection, hPIV-2 infection induced neither tetherin mRNA nor protein expression...
April 28, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28455520/a-humanized-mouse-model-identifies-key-amino-acids-for-low-immunogenicity-of-h7n9-vaccines
#3
Yamato Wada, Arnone Nithichanon, Eri Nobusawa, Leonard Moise, William D Martin, Norio Yamamoto, Kazutaka Terahara, Haruhisa Hagiwara, Takato Odagiri, Masato Tashiro, Ganjana Lertmemongkolchai, Haruko Takeyama, Anne S De Groot, Manabu Ato, Yoshimasa Takahashi
Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the human genome, the links between the T-cell epitopes and low immunogenicity of H7 HA remains unknown due to the lack of animal models reproducing the response observed in humans. Here, we utilized a humanized mouse model to recapitulate the low immunogenicity of H7 HA...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455444/endophilin-b2-facilitates-endosome-maturation-in-response-to-growth-factor-stimulation-autophagy-induction-and-influenza-a-virus-infection
#4
Jacob M Serfass, Yoshinori Takahashi, Zhixiang Zhou, Yuka Imamura Kawasawa, Ying Liu, Nikolaos Tsotakos, Megan M Young, Zhenyuan Tang, Linlin Yang, Jennifer M Atkinson, Zissis C Chroneos, Hong-Gang Wang
Endocytosis, and the subsequent trafficking of endosomes, requires dynamic physical alterations in membrane shape that are mediated in part by endophilin proteins. The endophilin B family of proteins contains an N-terminal Bin/Amphiphysin/Rvs (N-BAR) domain that induces membrane curvature to regulate intracellular membrane dynamics. While endophilin B1 (SH3GLB1/Bif-1) is known to be involved in a number of cellular processes, including apoptosis, autophagy and endocytosis, the cellular function of endophilin B2 (SH3GLB2) is not well understood...
April 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28455174/improving-adult-immunization-equity-where-do-the-published-research-literature-and-existing-resources-lead
#5
REVIEW
Wendy Prins, Emily Butcher, Laura Lee Hall, Gary Puckrein, Bernard Rosof
Evidence suggests that disparities in adult immunization (AI) rates are growing. Providers need adequate patient resources and information about successful interventions to help them engage in effective practices to reduce AI disparities. The primary purposes of this paper were to review and summarize the evidence base regarding interventions to reduce AI disparities and to scan for relevant resources that could support providers in their AI efforts to specifically target disparities. First, building on a literature review conducted by the U...
April 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28455173/the-impacts-of-email-reminder-recall-on-adolescent-influenza-vaccination
#6
Kevin J Dombkowski, Anne E Cowan, Sarah L Reeves, Matthew R Foley, Amanda F Dempsey
BACKGROUND: We sought to: (1) explore the feasibility of using email for seasonal influenza vaccination reminders to parents of adolescents and (2) assess influenza vaccination rates among adolescents whose parents were randomized to either receive or not receive email reminders. METHODS: Email addresses were obtained for parents of patients 10-18years from 4 practices in Michigan. Addresses were randomized to either receive email reminders, or not. Reminder messages were sent during October 2012-March 2013 (Season 1) and October 2013-March 2014 (Season 2)...
April 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28454888/cardiogenic-shock-and-cardiac-tamponade-in-the-context-of-influenza-a-myopericarditis
#7
Aridane Cárdenes León, Elena Gallardo Santos, Roland Prada Osorio, Marta López Pérez, Pedro Luis Martín Lorenzo
No abstract text is available yet for this article.
April 25, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28453859/temporal-and-spatial-characteristics-of-highly-pathogenic-avian-influenza-outbreaks-in-china-during-2004-to-2015
#8
Mingyue Liu, Qian Lu, Shuxia Zhang, Xiaolong Feng, Md Shakhawat Hossain
Identifying the temporal and spatial characteristics of highly pathogenic avian influenza (HPAI) outbreaks is very important for developing effective and appropriate countermeasures against HPAI and promoting sustainable development in the poultry industry. This study aimed to analyze four aspects of the temporal and spatial characteristics of HPAI outbreaks in China, including the frequency of HPAI outbreaks, numbers of dead animals (died or culled), types of HPAI viruses, and species of infected animals. Temporal characteristics showed that the frequency of HPAI outbreaks decreased and then increased, with some years deviating from the main trend in 2004 to 2010 and 2011 to 2015, while the largest number of dead animals due to HPAI outbreaks was in 2005...
April 26, 2017: Poultry Science
https://www.readbyqxmd.com/read/28453852/untangling-the-effects-of-prior-vaccination-on-subsequent-influenza-vaccine-effectiveness
#9
Joshua G Petrie, Arnold S Monto
No abstract text is available yet for this article.
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453845/effect-of-repeated-vaccination-with-the-same-vaccine-component-against-2009-pandemic-influenza-a-h1n1-virus
#10
Iván Martínez-Baz, Itziar Casado, Ana Navascués, Jorge Díaz-González, Aitziber Aguinaga, Laura Barrado, Josu Delfrade, Carmen Ezpeleta, Jesús Castilla
Background.: The 2009 pandemic influenza A(H1N1) (A[H1N1]pdm09) vaccine component has remained unchanged from 2009. We estimate the effectiveness of current and prior inactivated influenza A(H1N1)pdm09 vaccination from influenza seasons 2010-2011 to 2015-2016. Methods.: Patients attended with influenza-like illness were tested for influenza. Four periods with continued A(H1N1)pdm09 circulation were included in a test-negative design. Results.: We enrolled 1278 cases and 2343 controls...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28452706/respiratory-viral-detection-in-the-paranasal-sinuses-of-patients-with-cystic-fibrosis
#11
Nicholas R Rowan, Eric W Wang, Alyssa Kanaan, Nivedita Sahu, John V Williams, Caleb D Phillips, Stella E Lee
BACKGROUND: Pulmonary colonization with antibiotic-resistant organisms in patients with cystic fibrosis (CF) is often preceded by upper-airway infections. Although there is a well-described relationship between pulmonary respiratory viral infections and overall disease progression of CF, the pathogenicity of respiratory viral infections in the paranasal sinuses of patients with CF remains unknown. With recent advances in respiratory virus detection techniques, this study sought to detect the presence of respiratory viruses in the paranasal sinuses of patients with CF in comparison with healthy controls and to correlate the viral presence with clinical measures of sinonasal disease...
March 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28452003/the-public-health-impact-of-the-so-called-fluad-effect-on-the-2014-2015-influenza-vaccination-campaign-in-italy-ethical-implications-for-health-care-workers-and-health-communication-practitioners
#12
Roberto Rosselli, Mariano Martini, Nicola Luigi Bragazzi, Abdulla Watad
Seasonal influenza, causing complications, hospitalizations and deaths, generates a serious socio-economic burden, especially among elderly and high-risk subjects, as well as among adult individuals. Despite the availability and active free-of charge offer of influenza vaccines, vaccine coverage rates remain low and far from the target established by the Ministry of Health. Notwithstanding their effectiveness, vaccines are victims of prejudices and false myths, that contribute to the increasing phenomenon of vaccine hesitancy and loss of confidence...
April 28, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28450902/role-of-neural-barriers-in-the-pathogenesis-and-outcome-of-streptococcus-pneumoniae-meningitis
#13
Ofer Prager, Alon Friedman, Yaffa Mizrachi Nebenzahl
Bacterial meningitis is an inflammatory disease of the meninges of the central nervous system (CNS). Streptococcus pneumoniae (S. pneumoniae), Neisseria meningitidis, and Haemophilus influenzae are the major bacterial pathogens causing meningitis with S. pneumoniae being responsible for two thirds of meningitis cases in the developed world. To reach the CNS following nasopharyngeal colonization and bacteraemia, the bacteria traverse from the circulation across the blood brain barrier (BBB) and choroid plexus...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28450511/complete-genome-sequence-of-bordetella-pertussis-pelita-iii-the-production-strain-for-an-indonesian-whole-cell-pertussis-vaccine
#14
Yusuf Sofyan Efendi, Dwi Susanti, Erman Tritama, Michelle Lueders Pasier, Gilang Nadia Niwan Putri, Sugeng Raharso, Iskandar, Pingkan Aditiawati, Ernawati Arifin Giri-Rachman, Biswarup Mukhopadhyay, Endang Purwantini
PT Bio Farma, the sole World Health Organization-approved Indonesian vaccine producer, manufactures a whole-cell whooping cough vaccine (wP) that, as part of a pentavalent diphtheria-tetanus-pertussis/hepatitis B/Haemophilus influenzae b (DTP/HB/Hib) vaccine, is used in Indonesia and many other countries. We report here the whole-genome sequence for Bordetella pertussis Pelita III, PT Bio Farma's wP production strain.
April 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28450173/a-method-for-the-improved-detection-of-aerosolized-influenza-viruses-and-the-male-specific-f-rna-coliphage-ms2
#15
J C Chandler, J W Schaeffer, M Davidson, S L Magzamen, A Pérez-Méndez, S J Reynolds, L D Goodridge, J Volckens, A B Franklin, S A Shriner, B Bisha
The detection of aerosolized viruses can serve as an important surveillance and control tool in agriculture, human health, and environmental settings. Here, we adapted an anion exchange resin-based method, initially developed to concentrate negatively charged viruses from water, to liquid impingement-based bioaerosol sampling. In this method, aerosolized viruses are collected in a 20ml liquid sample contained within widely used impingers, BioSamplers (SKC Inc., Eighty Four, PA), and further concentrated via adsorption to an anion exchange resin that is suspended within this liquid...
April 24, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28449973/near-real-time-surveillance-for-guillain-barr%C3%A3-syndrome-after-influenza-vaccination-among-the-medicare-population-2010-11-to-2013-14
#16
Sukhminder K Sandhu, Wei Hua, Thomas E MaCurdy, Riley L Franks, Armen Avagyan, Jeffrey Kelman, Christopher M Worrall, Robert Ball, Michael Nguyen
BACKGROUND: Guillain-Barré syndrome (GBS) is a serious acute demyelinating disease that causes weakness and paralysis. The Food and Drug Administration (FDA) began collaborating with the Centers for Medicare and Medicaid Services (CMS) to develop near real-time vaccine safety surveillance capabilities in 2006 and has been monitoring for the risk of GBS after influenza vaccination for every influenza season since 2008. METHODS: We present results from the 2010/11 to 2013/14 influenza seasons using the Updating Sequential Probability Ratio Test (USPRT), with an overall 1-sided α of 0...
April 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28449972/effect-of-prophylactic-or-therapeutic-administration-of-paracetamol-on-immune-response-to-dtwp-hepb-hib-combination-vaccine-in-indian-infants
#17
Arijit Sil, Mandyam D Ravi, Badri N Patnaik, Mandeep S Dhingra, Martin Dupuy, Dulari J Gandhi, Sangappa M Dhaded, Anand P Dubey, Ritabrata Kundu, Sanjay K Lalwani, Jugesh Chhatwal, Leni G Mathew, Madhu Gupta, Shiv D Sharma, Sandeep B Bavdekar, Soumya P Rout, Midde V Jayanth, Naveena A D'Cor, Somnath A Mangarule, Suresh Ravinuthala, Jagadeesh Reddy E
BACKGROUND: Vaccination is considered as the most cost effective method for preventing infectious diseases. Low grade fever is a known adverse effect of vaccination. In India, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. Some studies have shown that paracetamol interferes with antibody responses following immunization. This manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in Indian infants where paracetamol was not used or was used either as prophylaxis or for treatment of fever...
April 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28449918/better-knowledge-and-regular-vaccination-practices-correlate-well-with-higher-seasonal-influenza-vaccine-uptake-in-people-at-risk-promising-survey-results-from-a-university-outpatient-clinic
#18
Işıl Adadan Güvenç, Hülya Parıldar, Mustafa Kürşat Şahin, Selim Sermed Erbek
BACKGROUND: The knowledge, beliefs, opinions, and attitudes of patients and their relatives regarding seasonal influenza vaccination were evaluated. METHODS: This descriptive study was undertaken in the outpatient clinics of Baskent University Hospital. There were 566 responders who completed a self-administered questionnaire. RESULTS: The mean age of participants was 48.35 years, and 16.8% were ≥65 years. Of the responders, 21.7% were vaccinated this year, whereas 57...
April 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28449916/psychosocial-determinants-of-influenza-vaccination-intention-a-cross-sectional-study-on-inpatient-nurses-in-singapore
#19
Dwee Wee Lim, Lay Tin Lee, Win Mar Kyaw, Angela Chow
Nurses have the closest interaction with inpatients and could transmit influenza to patients. From a self-administered questionnaire survey among inpatient nurses at a tertiary hospital, we observed that the strongest factors associated with intention for future vaccination were perceived benefits of and motivations for vaccination (adjusted odds ratio [aOR], 3.30; 95% confidence interval [CI], 2.55-4.27), and perceived nonsusceptibility to influenza and preference for vaccination alternatives (aOR, 0.26; 95% CI, 0...
April 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28449098/insights-on-persistent-airway-infection-by-nontypeable-haemophilus-influenzae-in-chronic-obstructive-pulmonary-disease
#20
Christian P Ahearn, Mary C Gallo, Timothy F Murphy
Nontypeable Haemophilus influenzae (NTHi) is the most common bacterial cause of infection of the lower airways in adults with chronic obstructive pulmonary disease (COPD). Infection of the COPD airways causes acute exacerbations, resulting in substantial morbidity and mortality. NTHi has evolved multiple mechanisms to establish infection in the hostile environment of the COPD airways, allowing the pathogen to persist in the airways for months to years. Persistent infection of the COPD airways contributes to chronic airway inflammation that increases symptoms and accelerates the progressive loss of pulmonary function, which is a hallmark of the disease...
April 25, 2017: Pathogens and Disease
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