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https://www.readbyqxmd.com/read/29241072/combined-efficacy-of-oseltamivir-isoprinosine-and-ellagic-acid-in-influenza-a-h3n2-infected-mice
#1
Elitsa L Pavlova, Lora S Simeonova, Galina A Gegova
Influenza pathogenesis comprises a complex cascade of impaired cellular processes resulting from the viral replication and exaggerated immune response accompanied by reactive oxygen species (ROS) burst and oxidative stress, destructing membranous structures and tissues. By classical virological and biochemical methods we compared and evaluated the therapeutic effects of 2.5mg/kg/day of the antiviral drug - oseltamivir (OS), 500mg/kg/day of the immune modulator - isoprinosine (IP) and 500mg/kg/day of the antioxidant agent ellagic acid (EA) with a focus on their combined activities in influenza H3N2 virus-infected mice...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29241038/through-the-scope-darkly-the-gut-mycobiome-comes-into-focus
#2
Nydiaris Hernández-Santos, Bruce S Klein
The gut microbiome is comprised of microbes from multiple kingdoms, including bacteria, but also fungi, viruses, and perhaps other agents. In this issue of Cell Host & Microbe, Jiang et al. (2017) reveal that fungal monocolonization after antibiotic-mediated depletion of intestinal bacteria prevents colitis and influenza, thus highlighting beneficial roles of fungi.
December 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29240526/wells-syndrome-secondary-to-influenza-vaccination-a-case-report-and-review-of-the-literature
#3
Tyler Safran, Marina Masckauchan, Jakub Maj, Lawrence Green
Vaccinations have been shown repeatedly to be extremely safe with low incidence of complications. Given the rarity, these adverse events, they must be reported and examined cautiously. This case report illustrates the first case of an adult presenting with Wells syndrome that developed soon after vaccination with the thiomersal, a common preservative, containing influenza vaccine. Wells syndrome, also known as eosinophilic cellulitis, is an uncommon dermatologic condition of unknown etiology. Lesions in patients with Wells syndrome (eosinophilic cellulitis) progress over a few days to become large indurated plaques with associated edema and erythema...
December 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29239682/safety-and-immunogenicity-of-a-seasonal-trivalent-inactivated-split-influenza-vaccine-a-phase-i-randomized-clinical-trial-in-healthy-serbian-adults
#4
Goran Stevanovic, Lidija Lavadinovic, Svetlana Filipovic Vignjevic, Renée Holt, Katarina Ilic, Francesco Berlanda Scorza, Erin Sparrow, Vera Stoiljkovic, Guido Torelli, Tamra Madenwald, Muriel Socquet, Aleksandra Barac, Yordanka Ilieva-Borisova, Mijomir Pelemis, Jorge Flores
This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45 years, were enrolled in the trial...
December 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29238328/impact-of-aerosol-dust-on-xmap-multiplex-detection-of-different-class-pathogens
#5
Denis A Kleymenov, Vladimir A Gushchin, Alexander L Gintsburg, Artem P Tkachuk
Environmental or city-scale bioaerosol surveillance can provide additional value for biodefense and public health. Efficient bioaerosol monitoring should rely on multiplex systems capable of detecting a wide range of biologically hazardous components potentially present in air (bacteria, viruses, toxins and allergens). xMAP technology from LuminexTM allows multiplex bead-based detection of antigens or nucleic acids, but its use for simultaneous detection of different classes of pathogens (bacteria, virus, toxin) is questionable...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237998/neutralization-antibody-response-to-booster-priming-immunization-with-new-equine-influenza-vaccine-in-japan
#6
Takashi Yamanaka, Manabu Nemoto, Hiroshi Bannai, Koji Tsujimura, Tomio Matsumura, Hiroshi Kokado, Sarah Gildea, Ann Cullinane
Equine influenza (EI) vaccine has been widely used. However, the causative EI virus (H3N8) undergoes continuous antigenic drift, and the vaccine strains must be periodically reviewed and if necessary, updated to maintain vaccine efficacy against circulating viruses. In 2016, the Japanese vaccine was updated by replacing the old viruses with the Florida sub-lineage Clade (Fc) 2 virus, A/equine/Yokohama/aq13/2010 (Y10). We investigated the virus neutralization (VN) antibody response to Fc2 viruses currently circulating in Europe, after booster or primary immunization with the new vaccine...
December 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29237841/mammalian-adaptation-of-an-avian-influenza-a-virus-involves-stepwise-changes-in-ns1
#7
C Chauché, A Nogales, H Zhu, D Goldfarb, A I Ahmad Shanizza, Q Gu, C R Parrish, L Martínez-Sobrido, J F Marshall, P R Murcia
Influenza A viruses (IAVs) are common pathogens of birds that occasionally establish endemic infections in mammals. The processes and mechanisms that result in IAV mammalian adaptation are poorly understood. The viral non-structural 1 (NS1) protein counteracts the interferon (IFN) response, a central component of the host-species barrier.We characterised the NS1 proteins of equine influenza virus (EIV), a mammalian IAV lineage of avian origin. We showed that evolutionary distinct NS1s counteract the IFN response using different and mutually exclusive mechanisms: while the NS1s of early EIVs block general gene expression by binding to the cellular polyadenylation specific factor 30 (CPSF30), NS1s from more evolved EIVs specifically block the induction of IFN-stimulated genes by interfering with the JAK/STAT pathway...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29237829/unexpected-functional-divergence-of-bat-influenza-virus-ns1-proteins
#8
Hannah L Turkington, Mindaugas Juozapaitis, Nikos Tsolakos, Eugenia Corrales-Aguilar, Martin Schwemmle, Benjamin G Hale
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins lack canonical receptor binding and destroying activity. Nevertheless, other features that distinguish these viruses from classical FLUAVs have yet to be explored. Here, we studied the viral non-structural protein, NS1, a virulence factor that modulates host signaling to promote efficient propagation...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29237781/pathogen-identification-by-multiplex-lightmix%C3%A2-rt-pcr-in-patients-with-meningitis-and-culture-negative-cerebrospinal-fluid
#9
Karoline Wagner, Burkard Springer, Valeria P Pires, Peter M Keller
Acute bacterial meningitis is a medical emergency, and delays in initiating effective antimicrobial therapy result in increased morbidity and mortality. Culture-based methods, thus far considered the "gold-standard" for identifying bacterial microorganisms, require 24 to 48 hours to provide a diagnosis. In addition, antimicrobial therapy is often started prior to clinical sample collection, thereby decreasing the probability to culturally confirm the bacterial pathogen. To enable a fast and accurate detection of the most important bacterial pathogens causing meningitis, namely S...
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29237774/quantitative-multiplexed-imaging-analysis-reveals-a-strong-association-between-immunogen-specific-b-cell-responses-and-tonsillar-germinal-center-immune-dynamics-in-children-after-influenza-vaccination
#10
Donato Amodio, Nicola Cotugno, Giulia Macchiarulo, Salvatore Rocca, Yiannis Dimopoulos, Maria Rita Castrucci, Rita De Vito, Filippo M Tucci, Adrian B McDermott, Sandeep Narpala, Paolo Rossi, Richard A Koup, Paolo Palma, Constantinos Petrovas
Generation of Ag-specific humoral responses requires the orchestrated development and function of highly specialized immune cells in secondary lymphoid organs. We used a multiparametric approach combining flow cytometry, confocal microscopy, and histocytometry to analyze, for the first time to our knowledge in children, tonsils from seasonal influenza-vaccinated children. We used these novel imaging assays to address the mucosal immune dynamics in tonsils investigating the spatial positioning, frequency, and phenotype of immune cells after vaccination...
December 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29237061/the-comparative-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccines-in-preventing-post-influenza-deaths
#11
Karl Madaras-Kelly, Richard Remington, Hayli Hruza, Dong Xu
No abstract text is available yet for this article.
December 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29236486/regioselective-ibx-mediated-synthesis-of-coumarin-derivatives-with-antioxidant-and-anti-influenza-activities
#12
Bruno M Bizzarri, Lorenzo Botta, Eliana Capecchi, Ignacio Celestino, Paola Checconi, Anna T Palamara, Lucia Nencioni, Raffaele Saladino
Different catechol and pyrogallol derivatives have been synthesized by oxidation of coumarins with 2-iodoxybenzoic acid (IBX) in DMSO at 25 °C. A high regioselectivity was observed in accordance with the stability order of the incipient carbocation or radical benzylic-like intermediate. The oxidation was also effective in water under heterogeneous conditions by using IBX supported on polystyrene. The new derivatives showed improved antioxidant effects in the DPPH test and inhibitory activity against the influenza A/PR8/H1N1 virus...
December 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29236360/low-risk-of-avian-influenza-a-h5n6-transmission-to-depopulation-workers-in-korea
#13
Sukhyun Ryu, Jun-Sik Lim, Benjamin J Cowling, Byung Chul Chun
An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016 and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing of respiratory swabs with real-time reverse transcription-polymerase chain reaction was performed for workers who reported respiratory symptoms. Among 4633 depopulation workers, 25 reported respiratory symptoms, but all tested negative for H5N6...
December 13, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29236357/live-attenuated-influenza-virus-vaccine-reduces-virus-shedding-of-newborn-piglets-in-the-presence-of-maternal-antibody
#14
Marika Genzow, Christa Goodell, Troy J Kaiser, Wesley Johnson, Marc Eichmeyer
BACKGROUND: Influenza A virus in swine (IAV-S) causes an acute respiratory disease of swine which results in great economic losses in pig production. Major control strategies include the use of killed vaccines (KV) in breeding females to confer passive immunity to their offspring. A bivalent H1N1 and H3N2 NS1-truncated live attenuated IAV-S vaccine has recently become available, which showed promising results in young pigs. OBJECTIVE: The aim of this study was to investigate the effect of an intranasal vaccination of newborn pigs with or without maternally derived antibodies (MDA) on virus shedding (via nasal swabs tested by virus isolation)...
December 13, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29236153/insufficient-vaccination-rates-in-patients-with-systemic-lupus-erythematosus-in-a%C3%A2-german-outpatient-clinic
#15
M Krasselt, C Baerwald, O Seifert
BACKGROUND: Patients with systemic lupus erythematosus (SLE) are at an increased risk of acquiring infections due to the disease itself and the immunosuppressive therapy. Furthermore, infections largely contribute to overall SLE mortality. Vaccinations against preventable diseases are therefore of particular importance for these patients. AIMS: To estimate vaccination frequencies among patients with SLE, we studied patients in a survey and calculated vaccination rates based on their vaccination documents...
December 13, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29236069/a-portrait-of-the-sialyl-glycan-receptor-specificity-of-the-h10-influenza-virus-hemagglutinin-a-picture-of-an-avian-virus-on-the-verge-of-becoming-a-pandemic
#16
REVIEW
Elena K Schneider, Jian Li, Tony Velkov
Pandemic influenza is a constant global threat to human health. In particular, the pandemic potential of novel avian influenza viruses such as the H10N7 and H10N8 avian strains, which recently managed to cross the species barrier from birds to humans, are always of great concern as we are unlikely to have any prior immunity. Human and avian isolates of H10 influenza display the ability to rapidly adapt to replication in mammalian hosts. Fortunately, so far there is no evidence of efficient human-to-human transmission of any avian influenza virus...
December 13, 2017: Vaccines
https://www.readbyqxmd.com/read/29236050/molecular-markers-for-interspecies-transmission-of-avian-influenza-viruses-in-mammalian-hosts
#17
REVIEW
Khristine Kaith S Lloren, Taehyung Lee, Jin Jung Kwon, Min-Suk Song
In the last decade, a wide range of avian influenza viruses (AIVs) have infected various mammalian hosts and continuously threaten both human and animal health. It is a result of overcoming the inter-species barrier which is mostly associated with gene reassortment and accumulation of mutations in their gene segments. Several recent studies have shed insights into the phenotypic and genetic changes that are involved in the interspecies transmission of AIVs. These studies have a major focus on transmission from avian to mammalian species due to the high zoonotic potential of the viruses...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29235984/deaths-leading-causes-for-2015
#18
Melonie Heron
Objectives-This report presents final 2015 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2015," the National Center for Health Statistics' annual report of final mortality statistics. Methods-Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2015. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD-10) are ranked according to the number of deaths assigned to rankable causes...
November 2017: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29235912/multiplex-one-step-real-time-pcr-detection-for-influenza-viruses-ah1pdm09-ah3-and-b
#19
Mariko Saito, Hiroyuki Tsukagoshi, Yu Takahashi, Nobuhiro Saruki
No abstract text is available yet for this article.
December 13, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29235573/constitutively-elevated-levels-of-socs1-suppress-innate-responses-in-df-1-immortalised-chicken-fibroblast-cells
#20
E S Giotis, C S Ross, R C Robey, A Nohturfft, S Goodbourn, M A Skinner
The spontaneously immortalised DF-1 cell line is rapidly replacing its progenitor primary chicken embryo fibroblasts (CEFs) for studies on avian viruses such as avian influenza but no comprehensive study has as yet been reported comparing their innate immunity phenotypes. We conducted microarray analyses of DF-1 and CEFs, under both normal and stimulated conditions using chicken interferon-α (chIFN-α) and the attenuated infectious bursal disease virus vaccine strain PBG98. We found that DF-1 have an attenuated innate response compared to CEFs...
December 13, 2017: Scientific Reports
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