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Jun-Jun Yeh, Cheng-Li Lin, Wu-Huei Hsu, Chia-Hung Kao
PURPOSE: To clarify the relationship between asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression. METHODS: We identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts...
2017: PloS One
Kaizhou Chen, Yongtao Wang, Jia Yao, Haoran Li
The degree of proton transfer and thermodynamic parameters of six acetate-based protic ionic liquids (PILs) were measured using nuclear magnetic resonance (NMR) spectroscopy and calculated by van't Hoff analytical method, respectively. The degree of proton transfer of these PILs at 298 K spread over a large range, which is from 39.6% (1-methylpyrrolidinium acetate, [MpyrH][AcO]) to 94.4% (1-butylimidazolium acetate, [BuimH][AcO]). The calculated standard enthalpy change of the reaction (∆_r H_m^θ) is from -23...
December 12, 2017: Journal of Physical Chemistry. B
Brystana G Kaufman, B Steven Spivack, Sally C Stearns, Paula H Song, Emily C O'Brien
Since 2010, more than 900 accountable care organizations (ACOs) have formed payment contracts with public and private insurers in the United States; however, there has not been a systematic evaluation of the evidence studying impacts of ACOs on care and outcomes across payer types. This review evaluates the quality of evidence regarding the association of public and private ACOs with health service use, processes, and outcomes of care. The 42 articles identified studied ACO contracts with Medicare ( N = 24 articles), Medicaid ( N = 5), commercial ( N = 11), and all payers ( N = 2)...
December 1, 2017: Medical Care Research and Review: MCRR
Luis Pérez de Llano, Borja G Cosío, Marc Miravitlles, Vicente Plaza
OBJECTIVES: We aimed to characterize the clinical, functional and inflammatory features of patients diagnosed diagnosed with ACO according to a new algorithm and to compare them with those of other chronic obstructive airway disease (COAD) categories (asthma and COPD). METHODS: ACO was diagnosed in a cohort of COAD patients in those patients with COPD who were either diagnosed with current asthma or showed significant blood eosinophilia (≥300cells/μl) and/or a very positive bronchodilator response (>400ml and >15% in FEV1)...
December 8, 2017: Archivos de Bronconeumología
Ömer Şahin, Ümmühan Özmen Özdemir, Nurgül Seferoğlu, Zuhal Karagöz Genc, Kerem Kaya, Burcu Aydıner, Suat Tekin, Zeynel Seferoğlu
A new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L)2] and [Pt(L)2]), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules...
November 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
Alejandra Enriquez Garcia, Farideh Jalilehvand
The aerobic reaction between glutathione (H3A) and dirhodium(II) tetraacetate, Rh2(AcO)4 (AcO- = CH3COO-), in aqueous solution (pH 7.4) breaks up the direct RhII-RhII bond and its carboxylate framework, as evidenced by UV-Vis spectroscopy. After purifying the reaction product using size exclusion chromatography, electrospray ionization mass spectrometry (ESI-MS) of the solution showed binuclear [Formula: see text] and [Formula: see text] ions. Evaporation yielded a solid compound, [Formula: see text], for which Rh K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy revealed ~ 2 Rh-O (2...
December 6, 2017: Journal of Biological Inorganic Chemistry: JBIC
Taressa K Fraze, Valerie A Lewis, Emily Tierney, Carrie H Colla
Accountable care organizations (ACOs), a primary care-centric delivery and payment model, aim to promote integrated population health, which may improve care for those with chronic conditions such as diabetes. Research has shown that, overall, the ACO model is effective at reducing costs, but there is substantial variation in how effective different types of ACOs are at impacting costs and improving care delivery. This study examines how ACO organizational characteristics - such as composition, staffing, care management, and experiences with health reform - were associated with quality of care delivered to patients with diabetes...
December 6, 2017: Population Health Management
Maciej Zakrzewski, Dominika Załubiniak, Piotr Piątek
Compound 1 was designed and prepared as a heteroditopic ion-pair receptor that contains two urea groups for anion complexation and N-benzyl-18-crown-6 for cation recognition. These ion-binding domains are assembled together by the l-ornithine scaffold. Qualitative cation coordination studies of receptor 1, supported by quantitative data received for monotopic N-(3-nitrobenzyl)-aza-18-crown-6 (3a), have shown that 1 has a strong affinity for Na+, K+ and NH4+ cations. Anion binding studies revealed that in the absence of cations coordinated to 1 (TBA salts), anions are bound with a relatively moderate strength with the selectivity: BzO- > AcO- > Cl-> NO2- > Br-...
December 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
David Michael Levine, Jeffrey A Linder, Bruce E Landon
BACKGROUND: Despite new incentives for US primary care, concerns abound that patient-centered practice capabilities are lagging. OBJECTIVE: Describe the practice structure, patient-centered capabilities, and payment relationships of US primary care practices; identify disparities in practice capabilities. DESIGN: Analysis of the 2015 Medical Organizations Survey (MOS), part of the nationally representative Medical Expenditure Panel Survey (MEPS)...
December 4, 2017: Journal of General Internal Medicine
Yanmei Cao, Cuicui Gu, Fangli Zhao, Yuanlin Tang, Xiaobing Cui, Le Shi, Li Xu, Lian Yin
Background: Cyathula officinalis Kuan is widely used in the clinics for the treatment of blood stasis in China. Objective: To evaluate the improving blood rheology and anti-inflammatory properties of C. officinalis Kuan extract (CO) and its active fraction (ACO) on acute blood stasis model Wistar rats and characterize the correlative constituents. Materials and Methods: CO at 0.26, 0.53, and 1.04 g/kg and ACO at 0.38, 0.75, and 1.5 g/kg were administered to acute blood stasis model Wistar rats for 3 days...
October 2017: Pharmacognosy Magazine
J Michael McWilliams, Michael E Chernew, Bruce E Landon
It has been widely assumed that better management and coordination of care for chronic conditions and high-risk patients would be the leading mechanisms for achieving savings in accountable care organizations (ACOs), specifically by reducing acute care needs through enhanced outpatient and preventive care. We examined the extent to which changes in spending and hospitalizations for ACO patients in the Medicare Shared Savings Program (MSSP) have been consistent with this expectation. By 2014, participation in the MSSP was associated with significant reductions in total Medicare fee-for-service spending for ACO patients but with proportionately smaller reductions in hospitalizations and some increases in hospitalizations for ambulatory care-sensitive conditions...
December 2017: Health Affairs
Yongli Yue, Lichun Zhang, Xiang Zhang, Xueling Li, Haiquan Yu
Adipose-derived mesenchymal stem cells (ADSCs) are useful cell model to study adipogenesis and energy metabolism. However, the biological characteristics of bovine ADSCs (bADSCs) remain unclear. This study aimed to isolate and identify bADSCs and further investigate fatty acid (FA)-related gene expression and composition of FAs during adipogenesis. The growth curve showed the bADSCs of P5 cells had rapid proliferation superior to P10-P50. The colony formation assay showed colony number of P5 cells was higher than that of P50 cells (51...
November 30, 2017: In Vitro Cellular & Developmental Biology. Animal
Shuzhi Liu, Min Yang, Yijiang Liu, Hongbiao Chen, Huaming Li
A new colorimetric fluorescent probe (MCy) for CN- is designed and synthesized based on triphenylimidazole-hemicyanine dyad. The probe shows high selectivity towards CN- in 100% aqueous solution even in the presence of other competitive anions such as F-, Cl-, AcO-, NO2-, H2PO4-, I-, SCN-, SO42-, NO3-, HCO3-, Br- and S2-. Upon nucleophilic addition of CN- to the indolium group, the probe displays large blue-shift in UV-vis spectrum and remarkable "turn-on" fluorescence owing to the disruption of intramolecular charge transfer...
November 24, 2017: Journal of Hazardous Materials
Chinnadurai Veeramani, Mohammed A Alsaif, Khalid S Al-Numair
BACKGROUND: Lipid accumulation is the most vital risk factor for inducing nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. Thus, the development of novel drugs is urgently needed to control obesity related diseases. OBJECTIVE: Here, we investigated the protective role of Lavatera critica (LC), a green vegetable, in male C57BL/6J mice fed with high fat (HF) diet for 10 weeks to induce hepatic lipid accumulation and oxidative cellular damage. RESULTS: After oral administration of chloroform (CFLC), ethyl acetate (EFLC), or methanol (MFLC) fractions of Lavatera critica to the HF group, EALC alone significantly reduced the activities of hepatic markers such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST); moreover, the results showed that 50 mg/kg dose has the maximum activity...
November 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Talha Burki
No abstract text is available yet for this article.
November 18, 2017: Lancet
Aaron Truchil, Natasha Dravid, Stephen Singer, Zachary Martinez, Teagan Kuruna, Scott Waulters
Accountable Care Organizations (ACOs) aim to reduce health care costs while improving patient outcomes. Camden Coalition of Healthcare Providers' (Camden Coalition) work already aligned with this aim before receiving state approval to operate a certified Medicaid ACO in New Jersey. Upon its formation, the Camden Coalition ACO partnered with UnitedHealthcare and, through state legislation, Rutgers Center for State Health Policy (CSHP) was established as its external evaluator. In evaluating the Camden Coalition ACO, Rutgers CSHP built on the Medicare Shared Savings model, but modified it based on the understanding that the Medicaid population differs from the Medicare population...
November 21, 2017: Population Health Management
Maarten van den Berge
No abstract text is available yet for this article.
2017: Tanaffos
Maarten van den Berge
No abstract text is available yet for this article.
2017: Tanaffos
Kian Fan Chung
No abstract text is available yet for this article.
2017: Tanaffos
Víctor Manuel Ruíz-Valdiviezo, Marco Antonio Rogel-Hernandez, Gabriela Guerrero, Clara Ivette Rincón-Molina, Luis Galdino García-Perez, Federico Antonio Gutiérrez-Miceli, Juan José Villalobos-Maldonado, Aline López-López, Esperanza Martinez-Romero, Reiner Rincón-Rosales
We report here the complete genome sequence of Rhizobium sp. strain ACO-34A, isolated from Agave americana L. rhizosphere. No common nod genes were found, but there were nif genes for nitrogen fixing. A low average nucleotide identity to reported species supports its designation as a novel Rhizobium species that has a complete ribosomal operon in a plasmid.
November 16, 2017: Genome Announcements
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