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https://www.readbyqxmd.com/read/29458019/raffinose-from-costus-speciosus-attenuates-lipid-synthesis-through-modulation-of-ppars-srebp1c-and-improves-insulin-sensitivity-through-pi3k-akt
#1
Muthukumaran Padmanaban, Thiyagarajan Gopal, Arun Babu Rajendran, Baddireddi Subhadra Lakshmi
Among several metabolic disorders, the pathogenesis of insulin resistance is considered to be multifactorial. Raffinose, an oligosaccharide isolated from the rhizome of Costus speciosus showed ≤50% inhibition of lipid accumulation in differentiated HepG2 and 3T3-L1 cells through exhibiting partial agonism to PPARγ, and, an enhanced secretion of adiponectin in 3T3-L1 adipocytes. Raffinose was also observed to attenuate the expression of SREBP1c, ACC and FAS which are involved in the fatty acid synthesis. A corresponding upregulation of PPARα and ACO involved in fatty acid oxidation was observed in steatotic HepG2 hepatocytes and 3T3-L1 adipocytes...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29454876/the-development-and-psychometric-validation-of-an-instrument-to-evaluate-nurses-attitudes-towards-communication-with-the-patient-aco
#2
María Del Carmen Giménez-Espert, Vicente Javier Prado-Gascó
BACKGROUND: Patient communication is a key skill for nurses involved in clinical care. Its measurement is a complex phenomenon that can be addressed through attitude evaluation. OBJECTIVES: To develop and psychometrically test a measure of nurses' attitudes towards communication with patients (ACO), to study the relationship between these dimensions, and to analyse nursing attitudes. DESIGN: To develop and psychometrically test the ACO questionnaire...
February 7, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29433946/definition-and-diagnosis-of-asthma-copd-overlap-aco
#3
REVIEW
Satoru Yanagisawa, Masakazu Ichinose
It is now widely recognized that asthma and COPD can coexist as asthma-COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. In addition, we cite the scientific evidence for our own "objective" features used to develop the criteria for COPD and asthma diagnosis...
February 9, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29420318/disparities-in-rates-of-surgical-intervention-among-racial-and-ethnic-minorities-in-medicare-accountable-care-organizations
#4
Andrew J Schoenfeld, Daniel J Sturgeon, Justin B Dimick, Christopher M Bono, Justin A Blucher, Lauren B Barton, Joel S Weissman, Adil H Haider
OBJECTIVE: To assess the effect of Accountable Care Organizations (ACOs) on the use of surgical services among racial and ethnic minorities. BACKGROUND: Health reform efforts were expected to reduce healthcare disparities. The impact of ACOs on existing disparities in access to surgical care remains unknown. METHODS: We used national Medicare data (2009-2014) to compare rates of surgery among white, African American, Hispanic, and Asian Medicare beneficiaries for coronary artery bypass grafting, colectomy, total hip arthroplasty, hip fracture repair, and lumbar spine surgery...
February 7, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29420087/prevalence-and-features-of-asthma-chronic-obstructive-pulmonary-disease-overlap-in-northern-italy-general-population
#5
Massimo Guerriero, Marco Caminati, Giovanni Viegi, Gianenrico Senna, Carlo Pomari
OBJECTIVE: There is controversy about the diagnostic criteria, prevalence, symptoms, and spirometry characteristics of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). Recent data indicate that the fixed method for diagnosing airway obstruction (AO) may overestimate ACO prevalence in the elderly, and a variable method may be more accurate. We aimed at estimating ACO prevalence in a general population sample and comparing patient and clinical features in subjects with ACO, COPD, and asthma...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29406837/optimization-of-medication-use-at-accountable-care-organizations
#6
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
May 30, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29401012/the-hidden-roles-that-management-partners-play-in-accountable-care-organizations
#7
Valerie A Lewis, Thomas D'Aunno, Genevra F Murray, Stephen M Shortell, Carrie H Colla
Accountable care organizations (ACOs) are often discussed and promoted as driven by physicians, hospitals, and other health care providers. However, because of the flexible nature of ACO contracts, management organizations may also become partners in ACOs. We used data from 2013-15 on 276 ACOs from the National Survey of Accountable Care Organizations to understand the prevalence of nonprovider management partners' involvement in ACOs, the services these partners provide, and the structure of ACOs that have such partners...
February 2018: Health Affairs
https://www.readbyqxmd.com/read/29400647/isoenzymatic-characterization-of-phlebotomus-ariasi-and-p-perniciosus-of-canine-leishmaniasis-foci-from-eastern-pyrenean-regions-and-comparison-with-other-populations-from-europe
#8
Cristina Ballart, Bernard Pesson, Montserrat Gállego
An entomological survey was carried out in 2007 in two Pyrenean counties of Lleida province (north-eastern Spain), where cases of autochthonous canine leishmaniasis have been recently reported. Phlebotomus ariasi and P. perniciosus, vectors of Leishmania infantum in the Mediterranean area, were captured. The aim of the present study was to compare these phlebotomine populations with others captured in known leishmaniasis foci in Europe. Populations of these species were studied by analysing the polymorphism of seven enzymatic systems (HK, PGI, PGM, MDH, 6PGD, FUM and ACO) and compared with other specimens from endemic regions of France, Italy, Malta, Portugal and Spain captured in other campaigns, and also with previously published results...
2018: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29397598/-the-clinical-significance-of-microcirculation-and-oxygen-metabolism-evaluation-in-acute-kidney-injury-assessment-in-patients-with-septic-shock-after-resuscitation
#9
C Yu, D W Liu, X T Wang, H W He, P Pan, Z Q Xing
Objective: To evaluate the value of microcirculation and oxygen metabolism evaluation (MicrOME) in acute kidney injury(AKI) evaluation in patients with septic shock after resuscitation. Methods: Consecutive patients with septic shock after resuscitation and mechanical ventilation were enrolled from October 2016 to February 2017 in ICU at Peking Union Medical College Hospital.Patients were divided into 3 groups based on 10 min transcutaneous oxygen challenge test transcutaneous partial pressure of oxygen(PtcO(2))and venoarterial pressure of carbon dioxide difference (Pv-aCO(2)) /arteriovenous O(2) content difference (Ca-vO(2)) by blood gas analysis, i...
February 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29393824/strategic-review-process-for-an-accountable-care-organization-and-emerging-accountable-care-best-practices
#10
Sarah J Conway, Sarah Himmelrich, Scott A Feeser, John A Flynn, Steven J Kravet, Jennifer Bailey, Lindsay C Hebert, Susan H Donovan, Sarah G Kachur, Patricia M C Brown, William A Baumgartner, Scott A Berkowitz
Accountable Care Organizations (ACOs), like other care entities, must be strategic about which initiatives they support in the quest for higher value. This article reviews the current strategic planning process for the Johns Hopkins Medicine Alliance for Patients (JMAP), a Medicare Shared Savings Program Track 1 ACO. It reviews the 3 focus areas for the 2017 strategic review process - (1) optimizing care coordination for complex, at-risk patients, (2) post-acute care, and (3) specialty care integration - reviewing cost savings and quality improvement opportunities, associated best practices from the literature, and opportunities to leverage and advance existing ACO and health system efforts in each area...
February 2, 2018: Population Health Management
https://www.readbyqxmd.com/read/29389608/nutrigenomic-studies-on-hilsa-to-evaluate-flesh-quality-attributes-and-genes-associated-with-fatty-acid-metabolism-from-the-rivers-hooghly-and-padma
#11
Satabdi Ganguly, Arabinda Mahanty, Tandrima Mitra, Sasmita Mohanty, Basanta Kumar Das, Bimal Prasanna Mohanty
The Indian shad hilsa (Tenualosa ilisha), a commercially important food fish rich in oils, enjoys high consumer preference in the South Asian countries owing to its unique flavour and culinary properties. The present study was undertaken with the primary objective of determining the flesh quality attributes of hilsa in terms of nutritive value (gross chemical composition, amino acid, fatty acid and mineral composition), pH, water holding capacity (WHC) and expression of genes associated with fatty acid metabolism and flesh quality...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29388199/medicare-accountable-care-organizations-of-diverse-structures-achieve-comparable-quality-and-cost-performance
#12
Leeann N Comfort, Stephen M Shortell, Hector P Rodriguez, Carrie H Colla
OBJECTIVE: To examine whether an empirically derived taxonomy of Accountable Care Organizations (ACOs) is associated with quality and spending performance among patients of ACOs in the Medicare Shared Savings Program (MSSP). DATA SOURCES: Three waves of the National Survey of ACOs and corresponding publicly available Centers for Medicare & Medicaid Services performance data for NSACO respondents participating in the MSSP (N = 204); SK&A Office Based Physicians Database from QuintilesIMS...
January 31, 2018: Health Services Research
https://www.readbyqxmd.com/read/29384022/clinical-and-economic-benefits-of-pharmacist-involvement-in-a-community-hospital-affiliated-patient-centered-medical-home
#13
Meredith L Tate, Sydney Hopper, Sean Paul Bergeron
BACKGROUND: The primary goals of an accountable care organization (ACO) are to reduce health care spending and increase quality of care. Within an ACO, pharmacists have a unique opportunity to help carry out these goals within patient-centered medical homes (PCMHs). Pharmacy presence is increasing in these integrated care models, but the pharmacist's role and benefit is still being defined. OBJECTIVE: To exhibit the clinical and economic benefit of pharmacist involvement in ACOs and PCMHs as documented by clinical interventions (CIs) and drug cost reductions...
February 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29374013/government-postpones-first-acos-to-allow-further-consultation
#14
Gareth Iacobucci
No abstract text is available yet for this article.
January 26, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29372418/tyrosine-residues-232-and-401-play-a-critical-role-in-the-binding-of-the-cofactor-fad-of-acyl-coa-oxidase
#15
Senwen Deng, Ping Li, Yiping Wang, Jia Zeng
Acyl-coA oxidase (ACO) is an important flavoenzyme responsible for the first step of peroxisomal fatty acid β-oxidation. In this study, the roles of Tyr232 and Tyr401 in flavin adenine dinucleotide (FAD) binding and enzyme catalysis of ACO were explored using site-directed mutagenesis. For mutant proteins, different levels of activity loss were observed. Wavelength scanning of Y232 and Y401 mutant proteins indicated that there is no FAD binding in Y401S and Y401G mutant ACO. Structure analysis indicated that the phenolic hydroxyl and benzene ring of the side chain could stabilize FAD binding through hydrogen bonds network and hydrophobic pocket formation...
January 25, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29368608/burden-of-asthma-and-copd-overlap-aco-in-taiwan-a-nationwide-population-based-study
#16
Sumitra Shantakumar, Raoh-Fang Pwu, Liesel D'Silva, Keele Wurst, Yao-Wen Kuo, Yen-Yun Yang, Yi-Chen Juan, K Arnold Chan
BACKGROUND: Patients with symptoms of both asthma and chronic obstructive pulmonary disease (COPD) may be classified with the term asthma-COPD overlap (ACO). ACO is of considerable interest as it is currently poorly characterised and has been associated with worse health outcomes and higher healthcare costs compared with COPD or asthma alone. Patients with ACO in Asia remain poorly described, and there is limited information regarding their resource utilisation compared with patients with asthma or COPD only...
January 25, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29368450/frequency-dependent-airway-hyperresponsiveness-in-a-mouse-model-of-emphysema-and-allergic-inflammation
#17
Kentaro Tamura, Koichiro Matsumoto, Satoru Fukuyama, Keiko Kan-O, Yumiko Ishii, Ken Tonai, Miyoko Tatsuta, Aimi Enokizu, Hiromasa Inoue, Yoichi Nakanishi
Asthma and chronic obstructive pulmonary disease (COPD), chronic airway inflammatory diseases characterized by airflow limitation, have different etiologies and pathophysiologies. Asthma-COPD Overlap (ACO) has recently been used for patients with mixed asthma and COPD. The pathophysiological mechanisms of ACO have not been clearly understood due to the lack of an appropriate murine model. To investigate its pathophysiology, we examined a murine model by allergen challenge in surfactant protein-D (SP-D)-deficient mice that spontaneously developed pulmonary emphysema...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29355677/asthma-copd-and-overlap-in-a-national-cohort-aco-on-a-gradient
#18
Arnaud Bourdin, Carey M Suehs, Gregory Marin, Isabelle Vachier, Eric Matzner-Lober, Pascal Chanez, Nicolas Molinari
No abstract text is available yet for this article.
January 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29338973/asthma-copd-overlap-a-portuguese-survey
#19
E Padrão, D Araújo, A Todo Bom, C Robalo Cordeiro, J Correia de Sousa, J Cardoso, M Morais-Almeida, R Costa, F Pavão, R B Leite, A Marques
INTRODUCTION: The overlap between asthma and chronic obstructive pulmonary disease (COPD) (ACO) has been discussed for many years but clinical recommendations for this entity have been diverse. This study is intended to reach a consensus on diagnosis, treatment and patient orientation for ACO, within the Portuguese medical community. METHODS: This study was conducted by a multidisciplinary panel of experts from three distinct medical specialties (Pulmonology, Family Medicine and Immunoallergology)...
January 12, 2018: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29313877/matriclans-shape-populations-insights-from-the-angolan-namib-desert-into-the-maternal-genetic-history-of-southern-africa
#20
Sandra Oliveira, Anne-Maria Fehn, Teresa Aço, Fernanda Lages, Magdalena Gayà-Vidal, Brigitte Pakendorf, Mark Stoneking, Jorge Rocha
OBJECTIVES: Southern Angola is a poorly studied region, inhabited by populations that have been associated with different migratory movements into southern Africa. Apart from Kx'a-speaking San foragers and Bantu-speaking pastoralists, ethnographic and linguistic studies have suggested the existence of an enigmatic array of pre-Bantu communities, like the Kwepe (formerly Khoe-Kwadi speakers), Twa and Kwisi. Here, we evaluate previous peopling hypotheses by assessing the relationships between different southern Angolan populations, based on newly collected linguistic data and complete mtDNA genomes...
January 3, 2018: American Journal of Physical Anthropology
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