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David Chukwuma Izuogu, Takefumi Yoshida, Haitao Zhang, Goulven Cosquer, Keiichi Katoh, Shuhei Ogata, Miki Hasegawa, Hiroyuki Nojiri, Marko Damjanović, Wolfgang Wernsdorfer, Tomoya Uruga, Toshiaki Ina, Brian K Breedlove, Masahiro Yamashita
Incorporating palladium in the first coordination sphere of acetato-bridged lanthanoid complexes, [Pd2Ln2(H2O)2(AcO)10]·2AcOH (Ln = Gd(1), Y(2), Gd0.4Y1.6(3), Eu(4)), led to significant bonding interactions between the palladium and the lanthanoid ions, which were demonstrated by experimental and theoretical methods. We found that electron density was donated from the d8 Pd2+ ion to Gd3+ ion in 1 and 3, leading to the observed slow magnetic relaxation by using local orbital locator (LOL) and X-ray absorption near edge structure (XANES)...
April 16, 2018: Chemistry: a European Journal
Hui Liu, Yuhong Zhou, Hanxia Li, Taotao Wang, Junhong Zhang, Bo Ouyang, Zhibiao Ye
NAC transcription factors (TFs) are important regulators of plant adaptation to abiotic stress. In this study, we functionally characterized an NAC TF, ShNAC1, from Solanum habrochaites. ShNAC1 was up-regulated by drought, cold, and salt stresses, and it displayed lower expression at the late stage of stress treatments than its orthologous gene in S. lycopersicum. Overexpression of ShNAC1 in tomato resulted in reduced cold, drought, and salt tolerance. Additionally, ShNAC1 displayed the highest expression in senescent leaf, and overexpressing ShNAC1 accelerated salt- and dark-induced leaf senescence...
June 2018: Plant Science: An International Journal of Experimental Plant Biology
Bernardino Alcázar-Navarrete, Francisca Castellano Miñán, Pablo Santiago Díaz, Oliveiro Ruiz Rodríguez, Pedro J Romero Palacios
INTRODUCTION: Exhaled nitric oxide (FENO ) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. METHODS: This was an observational cross-sectional study recruiting ambulatory COPD patients. FENO was measured, differentiating alveolar (CANO ) from bronchial (JawNO ) components using a multiple-flow technique. CANO and JawNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements...
April 4, 2018: Archivos de Bronconeumología
Yuan Gao, Jun Li, Xukun Pan, Dingrong Liu, Richard Napier, Liyao Dong
We previously reported that the mechanism of quinclorac resistance in Echinochloa crus-galli var. zelayensis may be closely related to ethylene biosynthesis and the detoxification of cyanide. Differences in EcCAS gene sequences and expression levels may result in higher capacity to detoxify cyanide in resistant biotypes, which may avoid cyanide accumulation and avoid more ethylene and cyanide production and then avoid damage. In the present study, we focused on the mechanism of resistance related to ethylene biosynthesis in E...
April 2018: Pesticide Biochemistry and Physiology
Jun Tamaoki, Kenji Izuhara
No abstract text is available yet for this article.
April 2018: Allergology International: Official Journal of the Japanese Society of Allergology
Xiao-Min Du, Xi-Lu Ni, Xiao-Long Ren, Gui-Liang Xin, Guo-Lun Jia, Hui-Dong Liu, Wen-Zhe Liu
Lysigenous aerenchyma is formed through programmed cell death (PCD) in Typha angustifolia leaves. However, the genome and transcriptome data for this species are unknown. To further elucidate the molecular basis of PCD during aerenchyma formation in T. angustifolia leaves, transcriptomic analysis of T. angustifolia leaves was performed using Illumina sequencing technology, revealing 73,821 unigenes that were produced by assembly of the reads in T1, T2 and T3 samples. The important pathways, such as programmed cell death (PCD), aerenchyma formation, and ethylene responsiveness were regulated by these unigenes...
April 3, 2018: Gene
Jing Li, Mark J Williams
The accountable care organization (ACO) concept is advocated as a promising value-based payment model that could successfully realign the current payment system to financially reward improvements in quality and efficiency. Focusing on the care of hospitalized patients and controlling a substantive portion of variable hospital expenses, hospitalists are poised to play an essential role in system-level transformational change to achieve clinical integration. Especially through hospital and health system quality improvement (QI) initiatives, hospitalists can directly impact and share accountability for measures ranging from care coordination to implementation of evidence-based care and the patient and family caregiver experience...
April 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Stephanie Mindus, Andrei Malinovschi, Linda Ekerljung, Bertil Forsberg, Thórarinn Gíslason, Rain Jõgi, Karl A Franklin, Mathias Holm, Ane Johannessen, Roelinde Middelveld, Vivi Schlünssen, Cecilie Svanes, Kjell Torén, Eva Lindberg, Christer Janson
BACKGROUND: The term Asthma and COPD Overlap (ACO) describes a condition where asthma and COPD overlap. We aimed to investigate associations between ACO and insomnia and respiratory symptoms, and to investigate the prevalence of ACO and the characteristics of subjects with ACO in two Northern European population studies. METHODS: The study comprised 25 429 subjects aged ≥ 40 years who participated in one of two Northern European general population surveys. Both surveys included questions on asthma, COPD, respiratory and sleep-related symptoms, including difficulty initiating sleep, difficulty maintaining sleep, early-morning awakening, and excessive daytime sleepiness...
2018: PloS One
Lonny Reisman
No abstract text is available yet for this article.
April 2018: Health Affairs
Natasa P Kalogiouri, Reza Aalizadeh, Nikolaos S Thomaidis
An optimized and validated LC-ESI-QTOF-MS method with an integrated non-target screening workflow was applied in the investigation of the metabolomic profile of 51 Greek monovarietal extra virgin olive oils (EVOOs) from the varieties: Manaki, Ladoelia, Koroneiki, Amfissis, Chalkidikis and Kolovi. Data processing was carried out with the R language and XCMS package. A local database consisting of 1608 compounds naturally occurring in different organs of Olea Europa L. was compiled in order to accelerate the identification workflow...
August 1, 2018: Food Chemistry
Ondrej Jurcek, Hennie Valkenier, Rakesh Puttreddy, Martin Novák, Hazel Sparkes, Radek Marek, Kari Rissanen, Anthony Peter Davis
Recent work has identified a bis-(p-nitrophenyl)ureidodecalin anion carrier as a promising candidate for biomedical applications, showing good activity for chloride transport in cells yet almost no cytotoxicity. To underpin further development of this and related molecules, we report a detailed structural and binding investigation. Crystal structures of the transporter as five solvates confirm the diaxial positioning of urea groups while revealing a degree of conformational flexibility. Structures of complexes with Cl-, Br-, NO3-, SO42-, and AcO-, supported by computational studies, show how the binding site can adapt to accommodate these anions...
March 30, 2018: Chemistry: a European Journal
Ailian Jiang, Lihong Zheng
Low cost, high reliability and easy maintenance are key criteria in the design of routing protocols for wireless sensor networks (WSNs). This paper investigates the existing ant colony optimization (ACO)-based WSN routing algorithms and the minimum hop count WSN routing algorithms by reviewing their strengths and weaknesses. We also consider the critical factors of WSNs, such as energy constraint of sensor nodes, network load balancing and dynamic network topology. Then we propose a hybrid routing algorithm that integrates ACO and a minimum hop count scheme...
March 29, 2018: Sensors
David Muhlestein, Katelyn de Lisle, Thomas Merrill
PURPOSE: Understand current provider approaches to the evaluation of various partnerships under accountable care contracts and create a framework to help accountable care organizations (ACOs) better assess their partnerships. DESIGN: Study included (1) an in-depth literature review of materials describing high-value health care organizations as a foundation for draft framework development, (2) an expert panel convened to evaluate the framework and help prioritize provider types to evaluate, and (3) interviews with representatives of ACOs and entities representing various types of health care providers...
March 2018: Managed Care
Sarah Kwon
Building on a similar effort in California, Catalyst for Payment Reform is proposing a standardized set of 50 ACO measures. A timely development. In the first quarter of last year, an estimated 19.1 million lives were covered by 715 commercial ACOs, compared with 17.2 million lives a year earlier.
March 2018: Managed Care
Axel C Mühlbacher, Volker E Amelung, Christin Juhnke
Introduction: Integrated care systems as well as accountable care organisations (ACOs) in the US and similar concepts in other countries are advocated as an effective method of improving the performance of healthcare systems. These systems outline a payment and care delivery model that intends to tie provider reimbursements to predefined quality metrics. By this the total costs of care shall be reduced. When designing healthcare options contractors are faced with a variety of financial options...
January 12, 2018: International Journal of Integrated Care
Bo Ding, Mark Small, Gina Scheffel, Ulf Holmgren
Background: In respiratory disorders, patient- and physician-perceived satisfaction with the maintenance inhaler device is an important factor driving treatment compliance and outcomes. We examine inhaler preferences in asthma and COPD from patient and physician perspectives, particularly focusing on the relative importance of individual device attributes and patient characteristics guiding inhaler choice. Materials and methods: Real-world data from >7,300 patients with asthma, COPD, or asthma-COPD overlap syndrome (ACOS) consulting for routine care were derived from respiratory Disease Specific Programs conducted in Europe, USA, Japan, and China...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Yuchen Zheng, Kun Lin, Thomas White, Jeremy Pickreign, Gigi Yuen-Reed
BACKGROUND: When a patient in a provider network seeks services outside of their community, the community experiences a leakage. Leakage is undesirable as it typically leads to higher out-of-network cost for patient and increases barrier for care coordination, which is particularly problematic for Accountable Care Organization (ACO) as the in-network providers are financially responsible for quality of care and outcome. We aim to design a data-driven method to identify naturally occurring provider networks driven by diabetic patient choices, and understand the relationship among provider composition, patient composition, and service leakage pattern...
March 27, 2018: BMC Health Services Research
Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He, Depeng Jiang
BACKGROUND: Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the early recognition of ACO is crucial. OBJECTIVES: We sought to explore the plasma levels of biomarkers associated with asthma (periostin, TSLP and YKL-40), COPD (NGAL) and their possible correlation with lung function, the bronchodilator response and radiographic imaging in patients with asthma, COPD and with features of ACO...
March 27, 2018: Respiratory Research
Jizhou Xia, Liang Lu, Cuiyuan Jin, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin
Lead (Pb) is one of the most prevalent toxic, nonessential heavy metals that has been associated with a wide range of toxic effects in humans and environmental animals. Here, effects of short time exposure to 10 and 30 μg/L Pb on gut microbiota and hepatic metabolism were analyzed in adult male zebrafish. We observed that both 10 and 30 μg/L Pb increased the volume of mucus in the gut. At phylum level, the abundance of α-Proteobacteria decreased significantly and the abundance of Firmicutes increased significantly in the gut when treated with 30 μg/L Pb for 7 days...
March 22, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
Chi-Chung Chen, Yi-Ting Liu
This paper proposes an enhanced ant colony optimization with dynamic mutation and ad hoc initialization, ACODM-I, for improving the accuracy of Takagi-Sugeno-Kang- (TSK-) type fuzzy systems design. Instead of the generic initialization usually used in most population-based algorithms, ACODM-I proposes an ad hoc application-specific initialization for generating the initial ant solutions to improve the accuracy of fuzzy system design. The generated initial ant solutions are iteratively improved by a new approach incorporating the dynamic mutation into the existing continuous ACO (ACOR )...
2018: Computational Intelligence and Neuroscience
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