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https://www.readbyqxmd.com/read/28821841/bacterial-foraging-optimization-genetic-algorithm-for-multiple-sequence-alignment-with-multi-objectives
#1
P Manikandan, D Ramyachitra
This research work focus on the multiple sequence alignment, as developing an exact multiple sequence alignment for different protein sequences is a difficult computational task. In this research, a hybrid algorithm named Bacterial Foraging Optimization-Genetic Algorithm (BFO-GA) algorithm is aimed to improve the multi-objectives and carrying out measures of multiple sequence alignment. The proposed algorithm employs multi-objectives such as variable gap penalty minimization, maximization of similarity and non-gap percentage...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818594/ultraviolet-and-solar-photocatalytic-ozonation-of-municipal-wastewater-catalyst-reuse-energy-requirements-and-toxicity-assessment
#2
Achisa C Mecha, Maurice S Onyango, Aoyi Ochieng, Maggy N B Momba
The present study evaluated the treatment of municipal wastewater containing phenol using solar and ultraviolet (UV) light photocatalytic ozonation processes to explore comparative performance. Important aspects such as catalyst reuse, mineralization of pollutants, energy requirements, and toxicity of treated wastewater which are crucial for practical implementation of the processes were explored. The activity of the photocatalysts did not change significantly even after three consecutive uses despite approximately 2% of the initial quantity of catalyst being lost in each run...
August 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28806586/the-new-frontier-of-strategic-alliances-in-health-care-new-partnerships-under-accountable-care-organizations
#3
Valerie A Lewis, Katherine I Tierney, Carrie H Colla, Stephen M Shortell
Accountable care organizations (ACOs) and similar reforms aim to improve coordination between health care providers; however, due to the fragmented nature of the US health care system, successful coordination will hinge in large part on the ability of health care organizations to successfully partner across organizational boundaries. Little is known about new partnerships formed under the ACO model. We use mixed methods data from the National Survey of ACOs, Medicare ACO performance data and interviews with executive leaders across 31 ACOs to examine the prevalence, characteristics, and capabilities of partnership ACOs and why and how ACO partnerships form...
May 2, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28803783/impact-of-mutations-within-the-fe-s-cluster-or-the-lipoic-acid-biosynthesis-pathways-on-mitochondrial-protein-expression-profiles-in-fibroblasts-from-patients
#4
E Lebigot, P Gaignard, I Dorboz, A Slama, M Rio, P de Lonlay, B Héron, F Sabourdy, O Boespflug-Tanguy, A Cardoso, F Habarou, C Ottolenghi, P Thérond, C Bouton, M P Golinelli-Cohen, A Boutron
Lipoic acid (LA) is the cofactor of the E2 subunit of mitochondrial ketoacid dehydrogenases and plays a major role in oxidative decarboxylation. De novo LA biosynthesis is dependent on LIAS activity together with LIPT1 and LIPT2. LIAS is an iron‑sulfur (Fe-S) cluster-containing mitochondrial protein, like mitochondrial aconitase (mt-aco) and some subunits of respiratory chain (RC) complexes I, II and III. All of them harbor at least one [Fe-S] cluster and their activity is dependent on the mitochondrial [Fe-S] cluster (ISC) assembly machinery...
August 3, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28801468/minnesota-integrated-health-partnership-demonstration-implementation-of-a-medicaid-aco-model
#5
Lynn A Blewett, Donna Spencer, Peter Huckfeldt
In recent years, accountable care organizations (ACOs) have become more prevalent in the United States, as a means to provide coordinated care by local providers. This study describes the origins, implementation, and early results of Minnesota's Medicaid ACO payment model, the Integrated Health Partnership (IHP) demonstration project. We describe the structure of the program and present preliminary evaluation results to document the state's important work and to provide lessons for other states interested in implementing Medicaid ACOs...
August 11, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28793967/type-2-diabetes-specialty-clinic-model-for-the-accountable-care-organization-era
#6
Heather Klingeman, Martha Funnell, Amolak Jhand, Sangeeta Lathkar-Pradhan, Israel Hodish
AIMS: A third of the patients with Type 2 diabetes have an advance disease that requires complex pharmacotherapies and advanced expertise, dependent on multiple clinical interactions. Unfortunately, limited providers availability enables only sporadic interactions. Additionally, the expanding Accountable Care Organization (ACO) concept enhances providers' compensation when clinical performance is improving while limiting face-to-face clinic visits. METHODS: We developed an advanced type 2 specialty clinic model, geared toward frequent remote clinical interventions while limiting face-to-face clinic visits...
May 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28793104/frailty-in-the-elderly-prevalence-and-associated-factors
#7
Jair Almeida Carneiro, Rafael Rodrigues Cardoso, Meiriellen Silva Durães, Maria Clara Araújo Guedes, Frederico Leão Santos, Fernanda Marques da Costa, Antônio Prates Caldeira
Objective: to know the prevalence and factors associated with frailty in elderly assisted by the Centro Mais Vida de Referência em Assistência à Saúde do Idoso (Mais Vida Health Reference Center for the Elderly) in the North of Minas Gerais, Brazil. Method: cross-sectional study, with sampling by convenience. Data collection occurred in 2015. Demographic and socioeconomic variables, morbidities, use of health services and the score of the Edmonton Frail Scale were analyzed...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28790809/clinical-characteristics-of-chronic-bronchitic-emphysematous-and-acos-phenotypes-in-copd-patients-with-frequent-exacerbations
#8
Yusheng Cheng, Xiongwen Tu, Linlin Pan, Shuai Lu, Ming Xing, Linlin Li, Xingwu Chen
PURPOSE: Chronic bronchitis (CB), emphysematous (EM) and asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) phenotypes in COPD are well recognized. This study aimed to investigate distinguishing characteristics of these phenotypes in COPD patients with frequent exacerbations (FE). PATIENTS AND METHODS: A retrospective study was carried out. COPD patients with acute exacerbations were consecutively reviewed from November 2015 to October 2016...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28782365/mechanism-of-amide-bond-formation-from-carboxylic-acids-and-amines-promoted-by-9-silafluorenyl-dichloride-derivatives
#9
Yuan-Ye Jiang, Ling Zhu, Yujie Liang, Xiaoping Man, Siwei Bi
The couplings of carboxylic acids and amines promoted by dichlorosilane derivatives provide a promising tool for amide synthesis and peptide coupling, in which an unprecedented mechanism was proposed for the amide bond formation process. To investigate this mechanistic proposal and enrich the understanding of this novel reaction, a theoretical study was conducted herein. The formation and interconversion of silylamine and silyl ester intermediates were calculated to be kinetically feasible under the experiment conditions...
August 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28767311/how-tpx2-helps-microtubules-branch-out
#10
Raymundo Alfaro-Aco, Sabine Petry
No abstract text is available yet for this article.
August 2, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28766649/a-triple-action-chemosensor-for-cu-2-by-chromogenic-cr-3-by-fluorogenic-and-cn-by-relay-recognition-methods-with-bio-imaging-of-hela-cells
#11
Natarajan Vijay, Gopal Balamurugan, Parthiban Venkatesan, Shu Pao Wu, Sivan Velmathi
A triple action chemosensor (R1) bearing a rhodamine and thiophene moiety was synthesized by a simple condensation reaction. The sensing behaviour and selectivity of the synthesized chemosensor toward metal ions were studied by UV-Vis and fluorescence spectroscopy. The chemosensor recognized Cu(2+) and Cr(3+) ions with significant changes in UV-Vis absorbance and fluorescence intensity. The results showed that Cr(3+) induced greater fluorescence enhancement whereas Cu(2+) ions bound strongly with the receptor by showing a strong absorption band at 554 nm but with weak fluorescence...
August 2, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28763762/selective-detection-of-pyrophosphate-anion-by-a-simple-cd-ii-based-terpyridine-complex
#12
Aditya Kumar Purohit, Biswa Nath Ghosh, Pravin Kumar Kar
A simple ratiometric terpyridine-Cd(ll) complex was synthesized by the treatment of CdCl2 with terpyridine ligand 4'-(4-N,N'-dimethylaminophenyl)-2,2':6',2″-terpyridine. The synthesized complex was found to act as a selective fluorescent chemosensor for pyrophosphate P2O7(4-) (PPi) over other anions like F(-), Cl(-), Br(-), CO3(2-), SO3(2-), AcO(-), NO2(-), and H2PO4(-). Furthermore, the receptor probe was also successfully employed in HeLa cell for PPi detection, which indicates this can be used as a chemosensor for cells...
July 25, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28748535/financial-incentives-and-physician-practice-participation-in-medicare-s-value-based-reforms
#13
Adam M Markovitz, Patricia P Ramsay, Stephen M Shortell, Andrew M Ryan
OBJECTIVES: To evaluate whether greater experience and success with performance incentives among physician practices are related to increased participation in Medicare's voluntary value-based payment reforms. DATA SOURCES/STUDY SETTING: Publicly available data from Medicare's Physician Compare (n = 1,278; January 2012 to November 2013) and nationally representative physician practice data from the National Survey of Physician Organizations 3 (NSPO3; n = 907,538; 2013)...
July 26, 2017: Health Services Research
https://www.readbyqxmd.com/read/28746556/potential-intravenous-drug-interactions-in-intensive-care
#14
Maiara Benevides Moreira, Maria Gefé da Rosa Mesquita, Marluci Andrade Conceição Stipp, Graciele Oroski Paes
OBJECTIVE: To analyze potential intravenous drug interactions, and their level of severity associated with the administration of these drugs based on the prescriptions of an intensive care unit. METHOD: Quantitative study, with aretrospective exploratory design, and descriptive statistical analysis of the ICU prescriptions of a teaching hospital from March to June 2014. RESULTS: The sample consisted of 319 prescriptions and subsamples of 50 prescriptions...
July 20, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28745524/should-patients-switched-from-d-to-b-in-the-gold-2017-classification-be-discontinued-from-inhaled-corticosteroids
#15
Matevz Harlander, Miriam Barrecheguren, Matjaz Turel, Marc Miravitlles
Inhaled corticosteroids (ICSs) are the cornerstone of the treatment of asthma, but their role in COPD is limited. Several guidelines recommend their use in patients with severe airflow limitation, frequent exacerbations and asthma-COPD overlap (ACO), while the previous GOLD document recommended ICS for patients with high risk of exacerbations and a high level of symptoms (group D). Following the changes in the GOLD document 2017 update, in which impaired lung function is no longer considered as a determinant of exacerbation risk, a high number of COPD patients can now be labeled as group B (low risk of exacerbations and high level of symptoms) instead of D, and hence, no longer fulfill the indication for ICS...
July 26, 2017: COPD
https://www.readbyqxmd.com/read/28740668/socioeconomic-impact-of-asthma-chronic-obstructive-pulmonary-disease-and-asthma-copd-overlap-syndrome
#16
Jinhee Kim, Young Sam Kim, Kyungjoo Kim, Yeon-Mok Oh, Kwang Ha Yoo, Chin Kook Rhee, Jin Hwa Lee
BACKGROUND: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is defined as having both features of asthma and COPD, which are airway hyper-responsiveness and incompletely reversible airway obstruction. However, socioeconomic impact of ACOS have not been well appreciated. METHODS: Adults with available wheezing history and acceptable spirometry were selected from the fourth Korean National Health and Nutrition Examination Survey (KNHANES IV) in 2007-2009...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740378/active-smoking-and-copd-phenotype-distribution-and-impact-on-prognostic-factors
#17
Juan Antonio Riesco, Bernardino Alcázar, Juan Antonio Trigueros, Anna Campuzano, Joselín Pérez, José Luis Lorenzo
PURPOSE: Smoking can affect both the phenotypic expression of COPD and factors such as disease severity, quality of life, and comorbidities. Our objective was to evaluate if the impact of active smoking on these factors varies according to the disease phenotype. PATIENTS AND METHODS: This was a Spanish, observational, cross-sectional, multicenter study of patients with a diagnosis of COPD. Smoking rates were described among four different phenotypes (non-exacerbators, asthma-COPD overlap syndrome [ACOS], exacerbators with emphysema, and exacerbators with chronic bronchitis), and correlated with disease severity (body mass index, obstruction, dyspnea and exacerbations [BODEx] index and dyspnea grade), quality of life according to the COPD assessment test (CAT), and presence of comorbidities, according to phenotypic expression...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28730518/the-case-for-enrolling-high-cost-patients-in-an-aco
#18
Abraham Graber, Shane Carter, Asha Bhandary, Matthew Rizzo
Though accountable care organizations (ACOs) are increasingly important to American healthcare, ethical inquiry into ACOs remains in its nascent stages. Several articles have raised the concern that ACOs have an incentive to avoid enrolling high-cost patients and, thereby, have an incentive to deny care to those who need it the most. This concern is borne out by the reports of consultants working with newly formed ACOs. This paper argues that, contra initial appearances, there is no financial incentive for ACOs to avoid enrolling high-cost patients...
July 20, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28712357/medicare-accountable-care-organizations-and-antidepressant-use-by-patients-with-depression
#19
Alisa B Busch, Haiden A Huskamp, Amanda R Kreider, J Michael McWilliams
OBJECTIVE: This study examined whether Medicare accountable care organization (ACO) programs were associated with early changes in antidepressant use or adherence among beneficiaries with depression. METHODS: A difference-in-difference design was used to compare claims from Medicare fee-for-service beneficiaries (2009-2013) and ACO patients with those from local control groups. Outcome measures were total antidepressant days supplied, filling one or more antidepressant prescriptions, and proportion of days covered (PDC) by supply among antidepressant users (adherence)...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28710004/development-of-pegylated-carboxylic-acid-modified-polyamidoamine-dendrimers-as-bone-targeting-carriers-for-the-treatment-of-bone-diseases
#20
Shugo Yamashita, Hidemasa Katsumi, Nozomi Hibino, Yugo Isobe, Yumiko Yagi, Kosuke Kusamori, Toshiyasu Sakane, Akira Yamamoto
In this study, we aimed to develop a polyethylene glycol (PEG)-conjugated third generation polyamidoamine (PAMAM) dendrimer with multiple carboxylic acids as a bone-targeting carrier for the treatment of bone diseases. We conjugated PAMAM backbones to various carboxylic acids [aspartic acid (Asp), glutamic acid (Glu), succinic acid (Suc), or aconitic acid (Aco)] to obtain four different types of carboxylic acid-modified PAMAMs. PEG was covalently bound to carboxylic acid-modified PAMAMs to obtain PEGylated carboxylic acid-modified PAMAMs...
July 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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