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https://www.readbyqxmd.com/read/29684786/gram-marks-the-spot-for-stim-commentary-on-gram-domain-proteins-specialize-functionally-distinct-er-pm-contact-sites-in-human-cells
#1
Paula Nunes, Nicolas Demaurex
GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.
April 18, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29684413/continue-to-focus-clinical-decision-making-on-the-antigen-recognition-domain-for-the-present
#2
REVIEW
Carolyn Katovich Hurley, Jennifer Ng
Next generation DNA sequencing has facilitated the routine characterization of complete HLA gene sequences. These data complement structural and functional studies of HLA elements encoded outside of the exons specifying the antigen recognition domain. This commentary is focused on evaluating whether the interpretation of HLA clinical typing results should expand the region of the HLA gene considered in the assignment from the exon(s) encoding the antigen recognition domain to the full gene sequence. Our recommendation is that, at present, there is insufficient data to support considering variation in the regions outside of the antigen recognition domain in clinical decision making...
April 20, 2018: Human Immunology
https://www.readbyqxmd.com/read/29684245/commentary-on-intestinal-fungi-contribute-to-development-of-alcoholic-liver-disease-yang-et-al-j-clin-invest-127-2829-2841-2017
#3
Gyongyi Szabo
No abstract text is available yet for this article.
April 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29684160/commentary-on-preoperative-use-of-neuromodulators-to-optimize-surgical-outcomes-in-upper-blepharoplasty-and-brow-lift
#4
Guy G Massry
No abstract text is available yet for this article.
April 19, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29684151/a-new-framework-for-patient-engagement-in-cancer-clinical-trials-cooperative-group-studies
#5
Patricia A Deverka, Rick Bangs, Karma Kreizenbeck, Deborah M Delaney, Dawn L Hershman, Charles D Blanke, Scott D Ramsey
For the past two decades, the National Cancer Institute (NCI) has supported the involvement of patient advocates in both internal advisory activities and funded research projects to provide a patient perspective. Implementation of the inclusion of patient advocates has varied considerably, with inconsistent involvement of patient advocates in key phases of research such as concept development. Despite this, there is agreement that patient advocates have improved the patient focus of many cancer research studies...
April 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29683367/insights-into-apoptotic-proteins-in-chemotherapy-quantification-techniques-and-informing-therapy-choice
#6
Janine Naß, Thomas Efferth
INTRODUCTION: Cancer is one of the leading causes of morbidity and mortality worldwide. A hallmark of cancer is evasion of apoptosis leading to tumor progression and drug resistance. Biomarker research has become a sign of the times, and proteins involved in apoptosis may be used for clinical diagnostic or prognostic purposes in cancer treatment. The recent progress in proteomic technology has triggered an emerging number of researchers to study the molecular mechanisms that regulate the apoptotic signal transduction pathways in cancer...
April 23, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29683362/immunogenicity-of-biologic-therapies-causes-and-consequences
#7
Wolf-Henning Boehncke, Nicolo Costantino Brembilla
Antibodies or fusion proteins termed biologics allow the targeted therapy of diseases. Many of these agents have proven superior efficacy and safety to conventional therapies, and subsequently revolutionized the management of numerous chronic diseases. Repetitive administration of these protein-based therapeutics to immunocompetent patients elicit immune responses in the form of Anti Drug Antibodies (ADAs), which in turn impact their pharmacological properties and may trigger adverse events. Areas covered: Structural characteristics determining the immunogenicity of biologics are reviewed along with strategies to minimize it...
April 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29683358/the-evolving-role-of-paramedics-a-nice-problem-to-have
#8
Georgette Eaton, Kamal Mahtani, Matt Catterall
This short essay supports the growing role of paramedics in the clinical and academic workforce. We present a commentary of recent draft consultations by the National Institute for Health and Care Excellence in England that set out how the role of paramedics may be evolving to assist with the changing demands on the clinical workforce. Using these consultations as a basis, we extend their recommendations and suggest that the profession should also lead the academically driven evaluation of these new roles.
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29682780/pharmacogenomic-information-in-the-warning-section-of-drug-labels-a-comparison-between-labels-in-the-united-states-and-those-in-five-other-countries-regions
#9
T Imatoh, K Sai, Y Saito
WHAT IS KNOWN AND OBJECTIVE: Clinically validated pharmacogenomic information useful for patient selection and/or dose adjustment is included in drug labels. However, the label information may differ among countries. This commentary summarizes the pharmacogenomic information on drug labels in different countries. COMMENT: We selected six drugs, namely, clopidogrel, atomoxetine, irinotecan, mercaptopurine, abacavir and carbamazepine and compared the pharmacogenomic information in the "Warning" section of these drug labels in the United States and 5 other countries/regions...
April 22, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29682634/commentary-mir-132-212-modulates-seasonal-adaptation-and-dendritic-morphology-of-the-central-circadian-clock
#10
Lucia Mendoza-Viveros, Karl Obrietan, Hai-Ying M Cheng
Daily rhythms in behavior and physiology are coordinated by an endogenous clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. This central pacemaker also relays day length information to allow for seasonal adaptation, a process for which melatonin signaling is essential. How the SCN encodes day length is not fully understood. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression by directing target mRNAs for degradation or translational repression. The miR-132/212 cluster plays a key role in facilitating neuronal plasticity, and miR-132 has been shown previously to modulate resetting of the central clock...
2018: Journal of Neurology & Neuromedicine
https://www.readbyqxmd.com/read/29682615/the-economic-case-for-precision-medicine
#11
Sean P Gavan, Alexander J Thompson, Katherine Payne
Introduction : The advancement of precision medicine into routine clinical practice has been highlighted as an agenda for national and international health care policy. A principle barrier to this advancement is in meeting requirements of the payer or reimbursement agency for health care. This special report aims to explain the economic case for precision medicine, by accounting for the explicit objectives defined by decision-makers responsible for the allocation of limited health care resources. Areas covered : The framework of cost-effectiveness analysis, a method of economic evaluation, is used to describe how precision medicine can, in theory, exploit identifiable patient-level heterogeneity to improve population health outcomes and the relative cost-effectiveness of health care...
2018: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/29682084/commentary-on-management-of-orbitocranial-non-missile-wounds
#12
Abbas Amirjamshidi, Kazem Abbassioun
No abstract text is available yet for this article.
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681521/commentary-to-bladder-exstrophy-closure-in-the-newborn-period-is-it-safe-to-perform-external-pelvic-fixation-without-osteotomy
#13
R Maximilian Cervellione
No abstract text is available yet for this article.
April 13, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29681202/quality-of-life-in-psoriatic-arthritis
#14
Tania Gudu, Laure Gossec
Psoriatic arthritis (PsA) is a multi-organ chronic inflammatory disease which impacts patients both physically and psychologically. The highest priority for patients goes to pain relief, but also to ability to function and participate in social life, fatigue, and psychological distress. Areas covered: In the present article, we will review current knowledge on impairments of health-related quality of life related to PsA, as well as patient priorities and patient-reported outcome measures such as the PsA Impact of Disease or the PsA Quality of Life questionnaires...
April 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29681201/cost-effectiveness-vs-affordability-in-the-age-of-immuno-oncology-cancer-drugs
#15
George Dranitsaris, Xiaofu Zhu, Georges Adunlin, Mark D Vincent
After years of setback, cancer immunotherapy has begun to yield clinical dividends, which are changing the treatment landscape and offering cancer patients the potential for long-term survival, reduced treatment-related toxicity and improved quality-of-life. Using the immune system to treat cancer is known as 'Immuno-oncology' (IO) and agents are sub-classified by their ability to enhance anti-tumor response or to direct the immune system to attack cancer cells via tumor-associated antigens. Areas covered: Clinical trials have demonstrated the effectiveness of several IO agents in many disease sites such as early and advanced stage melanoma, advanced non-small cell lung cancer, bladder, head and neck, gastric, kidney as well as Hodgkin's lymphoma...
April 23, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29681186/role-of-dendritic-cells-in-peanut-allergy
#16
Raquel Aguilera-Insunza, Luis F Venegas, Mirentxu Iruretagoyena, Leticia Rojas, Arturo Borzutzky
The prevalence of peanut allergy (PA) has increased, affecting approximately 1.1% of children in Western countries. PA causes life-threatening anaphylaxis and frequently persists for life. There are no standardized curative therapies for PA, and avoidance of peanuts remains the main therapeutic option. A better understanding of the pathogenesis of PA is essential to identify new treatment strategies. Intestinal dendritic cells (DCs) are essential in the induction and maintenance of food tolerance because they present dietary allergens to T cells, thereby directing subsequent immune responses...
April 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29680017/the-phosphate-bucket-list
#17
Tamara Isakova, Geoffrey Block
As our understanding of phosphate homeostasis has expanded over the last 20 years, additional quandaries have surfaced. Though the phosphate bucket list remains full, we are confident that the next 20 years will lead to major fundamental discoveries. In this commentary, we provide an example of how findings from a basic study that examined the mechanisms for circadian rhythms of plasma and urinary phosphate sheds light on important pathways that can be harnessed for novel therapeutic approaches in the future...
May 2018: Kidney International
https://www.readbyqxmd.com/read/29679677/use-of-toxicogenomics-in-drug-safety-evaluation-current-status-and-an-industry-perspective
#18
John L Vahle, Ulf Anderson, Eric A G Blomme, Jean-Christophe Hoflack, Daniel P Stiehl
Toxicogenomics held great promise as an approach to enable early detection of toxicities induced by xenobiotics; however, there remain questions regarding the impact of the discipline on pharmaceutical nonclinical safety assessment. To understand the current state of toxicogenomics in the sector, an industry group surveyed companies to determine the frequency of toxicogenomics use in in vivo studies at various stages of drug discovery and development and to assess how toxicogenomics use has evolved over time...
April 18, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29679533/creation-implementation-and-assessment-of-a-general-thoracic-surgery-simulation-course-in-rwanda-commentary
#19
David Tom Cooke
No abstract text is available yet for this article.
April 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29679438/the-use-of-the-arts-to-encourage-reflection-in-the-dental-professions-a-commentary
#20
J Lewis, K Jack
No abstract text is available yet for this article.
April 20, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
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