Nathalie Mantel, Fabienne Piras-Douce, Emilie Chautard, Ernesto Marcos-Lopez, Caroline L Bodinham, Antonio Cosma, Virginie Courtois, Nina Dhooge, Sylviane Gautheron, Stefan H E Kaufmann, Kathleen Pizzoferro, David J M Lewis, Frédéric Martinon, Anke Pagnon, Franck Raynal, Nathalie Dereuddre-Bosquet, Roger Le Grand
The non-human primate (NHP) model (specifically rhesus and cynomolgus macaques) has facilitated our understanding of the pathogenic mechanisms of yellow fever (YF) disease and allowed the evaluation of the safety and efficacy of YF-17D vaccines. However, the accuracy of this model in mimicking vaccine-induced immunity in humans remains to be fully determined. We used a systems biology approach to compare hematological, biochemical, transcriptomic, and innate and antibody-mediated immune responses in cynomolgus macaques and human participants following YF-17D vaccination...
April 3, 2024: Journal of Virology