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https://www.readbyqxmd.com/read/29350432/national-public-health-data-systems-in-the-united-states-applications-to-child-agricultural-injury-surveillance
#1
Barbara Marlenga, Richard L Berg, William Pickett
PURPOSE: The United States has no comprehensive national surveillance system for fatal or nonfatal child agricultural injuries. Thus, important knowledge gaps exist about recurrent injury patterns that could provide targeted focus for prevention efforts. The purpose of this study was to explore existing US public health data systems to determine their utility with respect to informing child agricultural injury surveillance and primary prevention. METHODS: Public health data systems were selected if they: (1) were national in scope, (2) were active and ongoing, (3) included physical injuries, and (4) contained a "farm" location variable...
January 19, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29331972/cohort-profile-the-comparative-outcomes-and-service-utilization-trends-coast-study-among-people-living-with-and-without-hiv-in-british-columbia-canada
#2
Oghenowede Eyawo, Mark W Hull, Kate Salters, Hasina Samji, Angela Cescon, Paul Sereda, Viviane D Lima, Bohdan Nosyk, David G T Whitehurst, Scott A Lear, Julio S G Montaner, Robert S Hogg
PURPOSE: The Comparative Outcomes And Service Utilization Trends (COAST) Study in British Columbia (BC), Canada, was designed to evaluate the determinants of health outcomes and health care services use among people living with HIV (PLHIV) as they age in the period following the introduction of combination antiretroviral therapy (cART). The study also assesses how age-associated comorbidities and health care use among PLHIV may differ from those observed in the general population. PARTICIPANTS: COAST was established through a data linkage between two provincial data sources: The BC Centre for Excellence in HIV/AIDS Drug Treatment Program, which centrally manages cART dispensation across BC and contains prospectively collected data on demographic, immunological, virological, cART use and other clinical information for all known PLHIV in BC; and Population Data BC, a provincial data repository that holds individual event-level, longitudinal data for all 4...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29324564/falls-assessment-and-interventions-among-older-patients-in-two-medical-and-one-surgical-hospital-wards-in-spain-a-best-practice-implementation-project
#3
Laura Albornos-Muñoz, Esther Melián-Correa, Amanda Acosta-Arrocha, Carmen Gallo-Blanco, Felicidad Béjar-Bacas, Emma Alonso-Poncelas, Montserrat Serra-Estrada, Esther González-María, María Teresa Moreno-Casbas
OBJECTIVE: The current project aimed to improve fall prevention and management through clinical audits and the implementation of a quality-improvement cycle at the local level. INTRODUCTION: Falls are one of the most common adverse events reported in hospitals; evidence-based fall prevention interventions aim to reduce the number of people who fall. METHODS: A one-year clinical audit was conducted using a pre-post implementation audit method, namely the Joanna Briggs Institute's (JBI) Practical Application of Clinical Evidence System and the getting research into practice audit and feedback tool...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29321079/the-enactment-stage-of-end-of-life-decision-making-for-children
#4
Jane Elizabeth Sullivan, Lynn Heather Gillam, Paul Terence Monagle
OBJECTIVES: Typically pediatric end-of-life decision-making studies have examined the decision-making process, factors, and doctors' and parents' roles. Less attention has focussed on what happens after an end-of-life decision is made; that is, decision enactment and its outcome. This study explored the views and experiences of bereaved parents in end-of-life decision-making for their child. Findings reported relate to parents' experiences of acting on their decision. It is argued that this is one significant stage of the decision-making process...
January 11, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29318771/safety-of-service-users-with-severe-mental-illness-receiving-inpatient-care-on-medical-and-surgical-wards-a-systematic-review
#5
REVIEW
Ella Reeves, Catherine Henshall, Marie Hutchinson, Debra Jackson
This review aimed to synthesize the evidence on the likelihood of harm and mortality on medical and surgical inpatient wards for people with severe mental illness (SMI). From 937 results identified through database searching, and a further 10 papers identified through citation searching and hand searching, 11 papers met the criteria for inclusion in the final review. This review did not find strong evidence for higher in-hospital mortality in people with SMI. There was evidence that adverse events are higher in people with SMI...
February 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29310899/efficacy-safety-and-tolerability-of-dolutegravir-rilpivirine-for-the-maintenance-of-virological-suppression-in-adults-with-hiv-1-phase-3-randomised-non-inferiority-sword-1-and-sword-2-studies
#6
Josep M Llibre, Chien-Ching Hung, Cynthia Brinson, Francesco Castelli, Pierre-Marie Girard, Lesley P Kahl, Elizabeth A Blair, Kostas Angelis, Brian Wynne, Kati Vandermeulen, Mark Underwood, Kim Smith, Martin Gartland, Michael Aboud
BACKGROUND: Lifelong HIV antiretroviral therapy (ART) has prompted an interest in two-drug regimens to minimise cumulative drug exposure and toxicities. The safety, tolerability, and efficacy of dolutegravir and rilpivirine suggest potential compatibility and effectiveness as a two-drug regimen. We aimed to investigate this two-drug regimen in a phase 3 study. METHODS: We identically designed SWORD-1 and SWORD-2, which were open-label, parallel-group, multicentre, phase 3, randomised, non-inferiority studies in 12 countries evaluating efficacy and safety of once-daily dolutegravir 50 mg plus rilpivirine 25 mg versus current ART regimen (CAR)...
January 5, 2018: Lancet
https://www.readbyqxmd.com/read/29310611/study-protocol-of-a-phase-ii-clinical-trial-kscc1501a-examining-oxaliplatin%C3%A2-%C3%A2-s-1-for-treatment-of-her2-negative-advanced-recurrent-gastric-cancer-previously-untreated-with-chemotherapy
#7
Hiroshi Saeki, Yasunori Emi, Eiji Oki, Shoji Tokunaga, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Eishi Baba, Yoshihiko Maehara
BACKGROUND: Oxaliplatin + S-1 is a recognized treatment regimen in Japan, but there are no Japanese clinical data on an oxaliplatin dose of 130 mg/m2. The current research involves a single-arm, prospective, phase II clinical trial to examine the efficacy and safety of oxaliplatin + S-1 with an oxaliplatin dose of 130 mg/m2 to treat HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy in Japan. METHODS/DESIGN: The primary endpoint of this trial will be the response rate, and the secondary endpoints will be the safety profile of oxaliplatin + S-1, progression-free survival, the response rate in subjects under the age of 75, overall survival, time to treatment failure, duration of treatment, time to failure of strategy, and dose intensity...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29309170/-in-honour-of-asclepius-and-orpheus-ten-years-of-activities-on-the-popularization-of-connections-between-medicine-and-music
#8
Tin Nadarević, Vesna Štefanac Nadarević
Art is defined as the expression or application of the human creative skill and imagination, producing works to be appreciated primarily for their beauty or emotional power. "Ars medica" and "Ars musica" represent two concepts which have been mutually intertwined since the ancient times. Through history, many extraordinary physicians have shown talent towards making and performing music. Guided by the passion for medicine and music, since 2006 the students from the University of Rijeka, Faculty of Medicine have founded an informal group named "In honour of Asclepius and Orpheus" under the aegis of the Croatian Scientific Society for the History of Health Culture...
December 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/29305770/deferasirox-for-the-treatment-of-iron-overload-after-allogeneic-hematopoietic-cell-transplantation-multicenter-phase-i-study-ksgct1302
#9
Takayoshi Tachibana, Junya Kanda, Shinichiro Machida, Takeshi Saito, Masatsugu Tanaka, Yuho Najima, Satoshi Koyama, Takuya Miyazaki, Eri Yamamoto, Masahiro Takeuchi, Satoshi Morita, Yoshinobu Kanda, Heiwa Kanamori, Shinichiro Okamoto
The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose of deferasirox that was determined by the intrapatient dose escalation methods. A total of 16 patients with post-HCT iron overload were enrolled in the study. After excluding one case of early relapse, 15 remained evaluable. Their median age was 42 years (range 22-68). Median time from HCT to deferasirox administration was 9 months (range 6-84)...
January 5, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29299356/fluoropyrimidine-induced-cardiac-toxicity-challenging-the-current-paradigm
#10
Suparna C Clasen, Bonnie Ky, Rupal O'Quinn, Bruce Giantonio, Ursina Teitelbaum, Joseph R Carver
Background: Fluoropyrimidine chemotherapy [5-fluorouracil (5-FU) and capecitabine] are commonly used agents in the treatment of various solid malignancies. However, their use has been limited by cardiac toxicity, presenting as a wide spectrum of asymptomatic (e.g., EKG changes) and symptomatic (e.g., chest pain) manifestations related to coronary vasospasm leading to myocardial ischemia. Historically, patients with suspected coronary vasospasm have been treated with traditional acute ischemic workup and various combinations of anti-anginal therapies...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29297655/the-emerging-role-of-gammacore-in-the-management-of-cluster-headache-expert-panel-recommendations
#11
Stephen D Silberstein, Anne H Calhoun, Christina Treppendahl, David W Dodick, Alan M Rapoport, Avinash Mamidi, Peter Vargas, Thomas H Ebert, Stewart J Tepper
A panel of 9 experts, including neurologists, other headache specialists, and medical and pharmacy directors, from 4 health plans (1 integrated delivery network and 3 plans with commercial, Medicare, and Medicaid lines of business), convened to discuss cluster headache (CH). Topics covered included the current treatment landscape, treatment challenges, economic impact of disease, and gaps in care for patients with CH. One major challenge in the management of CH is that it is underrecognized and frequently misdiagnosed, leading to delays in and suboptimal treatment for patients who suffer from this painful and disabling condition...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29295829/medication-therapy-management-after-hospitalization-in-ckd-a-randomized-clinical-trial
#12
Katherine R Tuttle, Radica Z Alicic, Robert A Short, Joshua J Neumiller, Brian J Gates, Kenn B Daratha, Celestina Barbosa-Leiker, Sterling M McPherson, Naomi S Chaytor, Brad P Dieter, Stephen M Setter, Cynthia F Corbett
BACKGROUND AND OBJECTIVES: CKD is characterized by remarkably high hospitalization and readmission rates. Our study aim was to test a medication therapy management intervention to reduce subsequent acute care utilization. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The CKD Medication Intervention Trial was a single-blind (investigators), randomized clinical trial conducted at Providence Health Care in Spokane, Washington. Patients with CKD stages 3-5 not treated by dialysis who were hospitalized for acute illness were recruited...
January 2, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29290171/health-care-costs-and-thromboembolic-events-in-hydroxyurea-treated-patients-with-polycythemia-vera
#13
Shreekant V Parasuraman, Nianwen Shi, Dilan C Paranagama, Machaon Bonafede
BACKGROUND: Patients with polycythemia vera (PV) are at increased risk of thromboembolic events (TEs), which are key contributors to reduced overall survival compared with the age- and sex-matched general population. In addition to aspirin and phlebotomy to maintain hematocrit level < 45%, many patients receive cytoreduction with hydroxyurea (HU), which is associated with improved survival and may reduce the risk of cardiovascular events and TEs. However, 1 in 4 patients become resistant to or intolerant of HU...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29288657/a-pragmatic-preoperative-prediction-score-for-non-home-discharge-after-cardiac-surgery
#14
Jenna Stuebe, Jessica Rydingsward, Heather Lander, Jillian Ng, Xinling Xu, Tsuyoshi Kaneko, Prem Shekar, Jochen D Muehlschlegel, Simon C Body
BACKGROUND: Targeted rehabilitation of patients at risk for non-home discharge (NHD) following surgery is an appealing area for quality improvement. We sought to identify the primary predictors of NHD following cardiac surgery in order to generate a robust preoperative prediction tool for those at greatest risk. METHODS: The medical records of 5,253 patients undergoing cardiac surgery between 1/1/2012 - 3/31/2016 were reviewed. Two models of NHD were created; a preoperative model using only preoperative predictors and a postoperative model using the same preoperative predictors, and including postoperative adverse outcomes and duration of hospital stay...
December 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29286930/hypoxic-ischemic-brain-injury-planned-delivery-before-intrapartum-events
#15
David Odd, Axel Heep, Karen Luyt, Tim Draycott
BACKGROUND: Mothers are increasingly given greater control over many of the choices around birth, although there is little robust evidence to inform these choices. After an infant is born with HIE the question of whether it was predictable, or preventable, is often raised. Intrapartum 'sentinel' events and antenatal predictors of HIE have been well described, however there is little evidence how antenatal and intrapartum factors interact. This is particularly important when elective delivery by lower segment caesarean section (LSCS) has been shown to be beneficial in high risk groups...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29284718/cohort-profile-study-of-transition-outcomes-and-gender-strong-to-assess-health-status-of-transgender-people
#16
Virginia P Quinn, Rebecca Nash, Enid Hunkeler, Richard Contreras, Lee Cromwell, Tracy A Becerra-Culqui, Darios Getahun, Shawn Giammattei, Timothy L Lash, Andrea Millman, Brandi Robinson, Douglas Roblin, Michael J Silverberg, Jennifer Slovis, Vin Tangpricha, Dennis Tolsma, Cadence Valentine, Kevin Ward, Savannah Winter, Michael Goodman
PURPOSE: The Study of Transition, Outcomes and Gender (STRONG) was initiated to assess the health status of transgender people in general and following gender-affirming treatments at Kaiser Permanente health plans in Georgia, Northern California and Southern California. The objectives of this communication are to describe methods of cohort ascertainment and data collection and to characterise the study population. PARTICIPANTS: A stepwise methodology involving computerised searches of electronic medical records and free-text validation of eligibility and gender identity was used to identify a cohort of 6456 members with first evidence of transgender status (index date) between 2006 and 2014...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29282099/the-focus-affinity-and-effects-trials-studying-the-effect-s-of-fluoxetine-in-patients-with-a-recent-stroke-statistical-and-health-economic-analysis-plan-for-the-trials-and-for-the-individual-patient-data-meta-analysis
#17
Catriona Graham, Steff Lewis, John Forbes, Gillian Mead, Maree L Hackett, Graeme J Hankey, John Gommans, Huy Thang Nguyen, Erik Lundström, Eva Isaksson, Per Näsman, Ann-Sofie Rudberg, Martin Dennis
BACKGROUND: Small trials have suggested that fluoxetine may improve neurological recovery from stroke. FOCUS, AFFINITY and EFFECTS are a family of investigator-led, multicentre, parallel group, randomised, placebo-controlled trials which aim to determine whether the routine administration of fluoxetine (20 mg daily) for six months after an acute stroke improves patients' functional outcome. METHODS/DESIGN: The core protocol for the three trials has been published (Mead et al...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29279973/psychiatric-symptoms-after-acute-respiratory-distress-syndrome-a-5-year-longitudinal-study
#18
O Joseph Bienvenu, Lisa Aronson Friedman, Elizabeth Colantuoni, Victor D Dinglas, Kristin A Sepulveda, Pedro Mendez-Tellez, Carl Shanholz, Peter J Pronovost, Dale M Needham
PURPOSE: We aimed to characterize anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms over 5-year follow-up after acute respiratory distress syndrome (ARDS) and determine risk factors for prolonged psychiatric morbidity. METHODS: This prospective cohort study enrolled patients from 13 medical and surgical intensive care units in four hospitals, with follow-up at 3, 6, 12, 24, 36, 48, and 60 months post-ARDS. Trained research staff administered the Hospital Anxiety and Depression Scale (HADS) (scores ≥ 8 on anxiety and depression subscales indicating substantial symptoms) and the Impact of Event Scale-Revised (IES-R, scores ≥ 1...
December 26, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29276211/treatment-patterns-statin-intolerance-and-subsequent-cardiovascular-events-among-japanese-patients-with-high-cardiovascular-risk-initiating-statin-therapy
#19
Saurabh P Nagar, Pratik P Rane, Kathleen M Fox, Juliana Meyers, Keith Davis, Anne Beaubrun, Hyoe Inomata, Yi Qian, Kouji Kajinami
BACKGROUND: This study examined treatment patterns, possible statin intolerance, and incidence of cardiovascular events (CVEs) in 2 cohorts of patients with high cardiovascular risk (i.e., patients with atherosclerotic cardiovascular disease [ASCVD] and patients with diabetes mellitus).Methods and Results:A retrospective cohort study examined adults initiating either a statin or ezetimibe from 1 January 2006 to 31 May 2014 in the Japan Medical Data Center database. The first observed statin or ezetimibe prescription defined the index date...
December 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29273897/impact-of-flash-glucose-monitoring-on-hypoglycaemia-in-adults-with-type-1-diabetes-managed-with-multiple-daily-injection-therapy-a-pre-specified-subgroup-analysis-of-the-impact-randomised-controlled-trial
#20
Per Oskarsson, Ramiro Antuna, Petronella Geelhoed-Duijvestijn, Jens Krӧger, Raimund Weitgasser, Jan Bolinder
AIMS/HYPOTHESIS: Evidence for the effectiveness of interstitial glucose monitoring in individuals with type 1 diabetes using multiple daily injection (MDI) therapy is limited. In this pre-specified subgroup analysis of the Novel Glucose-Sensing Technology and Hypoglycemia in Type 1 Diabetes: a Multicentre, Non-masked, Randomised Controlled Trial' (IMPACT), we assessed the impact of flash glucose technology on hypoglycaemia compared with capillary glucose monitoring. METHODS: This multicentre, prospective, non-masked, RCT enrolled adults from 23 European diabetes centres...
December 23, 2017: Diabetologia
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