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https://www.readbyqxmd.com/read/29771766/prevalence-of-extrapancreatic-malignancies-among-patients-with-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#1
Nikola Panic, Federico Macchini, Sonia Solito, Stefania Boccia, Emanuele Leoncini, Alberto Larghi, Debora Berretti, Sara Pevere, Salvatore Vadala, Marco Marino, Maurizio Zilli, Milutin Bulajic
OBJECTIVES: We conducted a study in order to assess the prevalence of extrapancreatic malignancies (EPMs) in a cohort of patients with intraductal papillary mucinous neoplasms (IPMNs) from northeast of Italy. METHODS: A study was conducted in hospital Santa Maria della Misericordia, Udine, Italy. Hospital records were screened in order to identify newly diagnosed IPMN cases in the period from January 1, 2009, to December 31, 2015. We searched for EPMs diagnosed previous to, synchronous to, or after the IPMN...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29766934/spectrum-of-metastatic-neoplasms-of-the-brain-a-clinicopathological-study-in-a-tertiary-care-cancer-centre
#2
Smrita Singh, Usha Amirtham, Chennagiri S Premalata, Kuntegowdanahalli C Lakshmaiah, Lokesh Viswanath, Rekha V Kumar
Background: While brain metastases (BM) are the most common causes of neurologic disorders in patients with known systemic malignancies, they can often be the initial manifestations of an undetected primary elsewhere. BM are major causes of morbidity and mortality in cancer patients. Aims: We describe a mixed population (data from both retrospective and prospective collection) having a BM from a solid tumor. We report the percentage distribution of the most frequent types of BM, confirming the data published in the literature...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29764500/the-role-of-initial-18-f-fdg-pet-ct-in-the-management-of-patients-with-suspected-extramedullary-plasmocytoma
#3
Linqi Zhang, Xu Zhang, Qiao He, Rusen Zhang, Wei Fan
BACKGROUND: Extramedullary plasmacytoma (EMP) is a plasma cell malignancy that originates in soft tissues without evidence of systemic spread, and its management differs from other plasma cell neoplasms. The purpose of the present study was to evaluate the role of initial 18 F-FDG PET/CT in the management of patients with clinical suspected EMP. METHODS: 18 F-FDG PET/CT scans performed in 21 patients (M/F = 12/9, mean age 51.1 ± 15.3 years) with clear suspicion of EMP from 2006 to 2015 were analysed retrospectively...
May 15, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29761357/classifying-brain-metastases-by-their-primary-site-of-origin-using-a-radiomics-approach-based-on-texture-analysis-a-feasibility-study
#4
Rafael Ortiz-Ramón, Andrés Larroza, Silvia Ruiz-España, Estanislao Arana, David Moratal
OBJECTIVE: To examine the capability of MRI texture analysis to differentiate the primary site of origin of brain metastases following a radiomics approach. METHODS: Sixty-seven untreated brain metastases (BM) were found in 3D T1-weighted MRI of 38 patients with cancer: 27 from lung cancer, 23 from melanoma and 17 from breast cancer. These lesions were segmented in 2D and 3D to compare the discriminative power of 2D and 3D texture features. The images were quantized using different number of gray-levels to test the influence of quantization...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29759590/reasons-for-non-participation-in-supplemental-population-based-mri-breast-screening-for-women-with-extremely-dense-breasts
#5
S V de Lange, M F Bakker, E M Monninkhof, P H M Peeters, P K de Koekkoek-Doll, R M Mann, M J C M Rutten, R H C Bisschops, J Veltman, K M Duvivier, M B I Lobbes, H J de Koning, N Karssemeijer, R M Pijnappel, W B Veldhuis, C H van Gils
AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme...
May 11, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29759486/inhibition-of-hdacs-epha2-signaling-axis-with-ww437-demonstrates-promising-preclinical-antitumor-activity-in-breast-cancer
#6
Tao Zhang, Jingjie Li, Xiaojun Ma, Yang Yang, Wei Sun, Wangrui Jin, Lei Wang, Yuan He, Feifei Yang, Zhengfang Yi, Yingqi Hua, Mingyao Liu, Yihua Chen, Zhengdong Cai
Histone deacetylase inhibitors (HDACi) are small molecules targeting epigenetic enzymes approved for hematologic neoplasms, which have also demonstrated clinical activities in solid tumors. In our present study, we screened our internal compound library and discovered a novel HDACi, WW437, with potent anti-breast cancer ability in vitro and in vivo. WW437 significantly inhibited phosphorylated EphA2 and EphA2 expression. Further study demonstrated WW437 blocked HDACs-EphA2 signaling axis in breast cancer. In parallel, we found that EphA2 expression positively correlates with breast cancer progression; and combined use of WW437 and an EphA2 inhibitor (ALW-II-41-27) exerted more remarkable effect on breast cancer growth than either drug alone...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29755815/late-endobronchial-pulmonary-metastasis-in-a-patient-with-breast-cancer
#7
İbrahim Güven Çoşğun, Turgut Kaçan, Gül Erten
The lung is a common location for malignant metastases. However, endobronchial metastases from nonpulmonary neoplasms are rare. Metastatic breast cancer usually occurs in 2-3 years of the disease course. A 65-year-old woman visited our hospital for the evaluation of dry cough. The patient had a history of breast cancer, which was treated with modified radical mastectomy and axillary dissection 10 years ago; she was then treated with aromatase inhibitor for 5 years. Chest X-ray revealed right hilum enlargement...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29751789/mechanisms-of-immune-evasion-in-breast-cancer
#8
Joshua P Bates, Roshanak Derakhshandeh, Laundette Jones, Tonya J Webb
Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at 'hiding' than others. With an increased understanding of tumor immune surveillance, immunotherapy has emerged as a promising treatment strategy for breast cancer, despite historically being thought of as an immunologically silent neoplasm. Some types of cancer, such as melanoma, bladder, and renal cell carcinoma, have demonstrated a durable response to immunotherapeutic intervention, however, breast neoplasms have not shown the same efficacy...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29751600/inflamed-phylloides-tumour-in-a-girl-a-challenging-diagnosis-in-paediatric-breast-lesions
#9
Ilaria Testa, Cristina Salvatori, Marco Prestipino, Maria Elena Laurenti, Paolo Gerli, Giuseppe Di Cara, Nicola Principi, Susanna Esposito, Mirko Bertozzi
Introduction : Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3⁻0.9% of all breast tumours. These tumours typically occur in women aged 30⁻70 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early diagnosis is mandatory because although most of the cases of PTs in children are benign, the borderline and malignant cases with potential negative outcomes cannot be excluded. Case presentation : A 12-year-old girl presented at the Paediatric Emergency Department for hyperaemia and warmth of the left breast that occurred a few days prior without fever...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29747750/crocus-sativus-a-natural-food-coloring-and-flavoring-has-potent-anti-tumor-properties
#10
REVIEW
Zahra Khorasanchi, Mojtaba Shafiee, Farnoush Kermanshahi, Majid Khazaei, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Behnoush Kermanshahi, Gordon A Ferns, Amir Avan, Seyed Mahdi Hassanian
BACKGROUND: Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural product that is used mainly as a food coloring and flavoring agent. Three main secondary metabolites of Crocus sativus including crocin, picrocrocin, and safranal are responsible for the color, the bitter taste and for the odor and aroma, respectively. As a component of traditional medicine, saffron has been utilized as a medicinal herb for treating various ailments including cramps, asthma, liver disease, menstruation disorders, pain, and in the pathogenesis of cancer...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29741263/the-2017-who-update-on-mature-t-and-natural-killer-nk-cell-neoplasms
#11
REVIEW
E Matutes
Over the last decade, there has been a significant body of information regarding the biology of the lymphoid neoplasms. This clearly supports the need for updating the 2008 WHO (World Health Organization) classification of haematopoietic and lymphoid tumours. The 2017 WHO classification is not a new edition but an update and revision of the 4th edition. New provisional entities but not new definitive entities are included, and novel molecular data in most of the entities and changes in the nomenclature in few of them have been incorporated...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29740502/estimating-the-incidence-of-breast-cancer-in-africa-a-systematic-review-and-meta-analysis
#12
REVIEW
Davies Adeloye, Olaperi Y Sowunmi, Wura Jacobs, Rotimi A David, Adeyemi A Adeosun, Ann O Amuta, Sanjay Misra, Muktar Gadanya, Asa Auta, Michael O Harhay, Kit Yee Chan
Background: Breast cancer is estimated to be the most common cancer worldwide. We sought to assemble publicly available data from Africa to provide estimates of the incidence of breast cancer on the continent. Methods: A systematic search of Medline, EMBASE, Global Health and African Journals Online (AJOL) was conducted. We included population- or hospital-based registry studies on breast cancer conducted in Africa, and providing estimates of the crude incidence of breast cancer among women...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29738361/intraductal-papillary-mucinous-neoplasms-of-minor-salivary-glands-with-akt1-p-glu17lys-mutation
#13
Abbas Agaimy, Sarina K Mueller, Klaus Bumm, Heinrich Iro, Evgeny A Moskalev, Arndt Hartmann, Robert Stoehr, Florian Haller
The spectrum of low-grade intraductal papillary proliferations of the salivary glands is heterogenous, and reproducible morphologic diagnostic criteria have not yet been established. Recognized types are sialadenoma papilliferum, inverted ductal papilloma, and intraductal papilloma, but some lesions have been possibly included in the morphologic spectrum of cystadenoma or low-grade intraductal carcinomas. We herein present detailed morphologic, immunophenotypic, and genotypic features of 3 minor salivary gland neoplasms affecting 2 men (aged 65 and 71 y) and 1 woman (aged 78 y)...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29731882/autologous-stem-cell-transplantation-in-ebv-positive-post-renal-transplant-refractory-multiple-myeloma-a-case-report-and-literature-review
#14
Xiaobao Xie, Yan Lin, Yang Cao, Weimin Dong, Wei Wu, Yuandong Zhu, Deliang Liu, Haiqian Li, Qing Li, Weiying Gu
Renal transplant recipients exhibit an increased risk of developing plasma cell neoplasms (PCNs; comprising multiple myeloma and plasmacytoma); however, multiple myeloma manifesting with refractory extramedullary plasmacytomas associated with Epstein-Barr virus are markedly rare in these patients. In the present case report, an unusual case of refractory multiple myeloma with multiple extramedullary plasmacytoma (including liver, vertebrae, breast, muscle, skin and soft tissues) was presented. The patient exhibited mild bone marrow infiltration which was successfully treated with novel agents, including bortezomib and lenalidomide, followed by autologous stem cell transplantation (ASCT)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29728085/pet-ct-incidental-detection-of-second-tumor-in-patients-investigated-for-pancreatic-neoplasms
#15
Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni, Cosimo Sperti
BACKGROUND: Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpected region of FDG (Fluorodeoxyglucose) uptake can occur when performing whole-body FDG-PET, raising the possibility of a second primary tumor. The aim of this study was to evaluate our experience of second primary cancer incidentally discovered during PET/CT examination performed for pancreatic diseases, during the initial work-up or follow-up after surgical resection...
May 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29726050/impact-of-two-nurse-led-interventions-targeting-diet-among-breast-cancer-survivors-results-from-a-randomized-controlled-trial
#16
M O Del Valle, R Martín-Payo, B Cuesta-Briand, A Lana
Breast cancer is the most common neoplasm among women worldwide. Improvements in early detection and treatment have resulted in improved survival rates; however, the continuation of unhealthy behaviours after diagnosis can increase the risk of second primary tumours. The aim of the study was to evaluate the effectiveness of two nurse-led health education interventions aiming at improving dietary behaviours among women diagnosed with breast cancer. Participants (n = 492) were included in a double-blind randomized controlled trial with three arms: a control group received usual care; women in the first intervention group received a booklet containing dietary advice; women in the second intervention group received the same booklet plus a tailored telephone intervention delivered by a trained nurse...
May 4, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29725531/intracranial-meningioma-as-primary-presentation-for-an-undiagnosed-collision-metastatic-breast-cancer-case-report-and-literature-review
#17
Ashraf Farrag, Jawaher Ansari, Muhammad Ali, Ghanem Sunbuli, Hassan Kassem, Abdul-Aziz Al Hamad
Intracranial metastasis from breast cancer is a relatively common finding, however, the appearance of breast cancer metastasis in a meningioma is very rare. Several cases of tumor-to-tumor metastasis and collision tumors have been reported previously, with meningioma being implicated as the most common benign intracranial neoplasm to harbour the metastasis. Occasionally, the discovery of a tumor-to-meningioma metastasis may herald the diagnosis of an occult primary malignancy. Careful histopathological assessment of the resected meningioma specimen is pivotal to the management of these patients, as this will alter the treatment plan and prognosis considerably...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29724710/improving-visualization-of-female-breast-cancer-survival-estimates-analysis-using-interactive-mapping-reports
#18
Awatef Ahmed Ben Ramadan, Jeannette Jackson-Thompson, Chester Lee Schmaltz
BACKGROUND: The Missouri Cancer Registry collects population-based cancer incidence data on Missouri residents diagnosed with reportable malignant neoplasms. The Missouri Cancer Registry wanted to produce data that would be of interest to lawmakers as well as public health officials at the legislative district level on breast cancer, the most common non-skin cancer among females. OBJECTIVE: The aim was to measure and interactively visualize survival data of female breast cancer cases in the Missouri Cancer Registry...
May 3, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29721318/central-airway-obstruction-caused-by-adenoid-cystic-carcinoma-in-pregnancy-a-case-report-and-review-of-the-literature
#19
Samaneh Shafiee, Alan Adno, Bruce French, Cherynne Johansson, Anthony Frankel, Jonathan P Williamson
Malignancy complicates one in a thousand pregnancies. The most frequently diagnosed of these are breast, cervical, melanoma, ovarian, and haematological neoplasms. Tumours of respiratory origin are very uncommon during pregnancy. We present a case of tracheal adenoid cystic carcinoma (ACC), a rare type of primary airway tumour, diagnosed in a pregnant woman. To our knowledge, this is the third reported case of tracheal ACC complicating pregnancy. We discuss potential barriers to timely diagnosis of malignancies during pregnancy and consider optimal management strategies, taking into account the potential harm to the mother and foetus in a field with a limited evidence base...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29720853/secondary-metastatic-lesions-to-colon-and-rectum
#20
REVIEW
Michail Galanopoulos, Filippos Gkeros, Christos Liatsos, Christos Pontas, Apostolis Papaefthymiou, Nikos Viazis, Gerassimos J Mantzaris, Nikolaos Tsoukalas
Metastatic lesions of the colon are a rare clinical entity that may present difficulties in management. The incidence of these metastases appears to be increasing, as a result of physicians' greater awareness during follow-up investigations of a primary neoplasm. Furthermore, the presence of a greater proportion of these abnormalities at autopsy should be a triggering factor for further investigation for doctors dealing with colorectal oncology. Their clinical presentation may vary from asymptomatic to signs similar to those of colorectal cancer...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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