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https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#1
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28210560/sinusoidal-hemangioma-of-the-breast-diagnostic-evaluation-management-and-literature-review
#2
Nikolaos S Salemis
Vascular tumors of the breast are rare and may pose a diagnostic challenge. Breast hemangioma is a very rare benign vascular neoplasm accounting for 0.4% of all breast tumors. It is most commonly detected as an incidental microscopic finding in biopsy specimens obtained for unrelated reasons. We describe here a very rare case of a sinusoidal breast hemangioma in a postmenopausal patient who presented with a palpable breast mass. A complete surgical resection was performed because the tumor exhibited atypical imaging features...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28203167/metastasis-of-colon-cancer-to-the-breast
#3
Swei H Tsung
Breast metastases from extramammary neoplasms are extremely rare, and even more so is metastasis of colon cancer to the breast. Despite its rarity, metastatic disease to the breast is an important diagnostic issue because its treatment differs greatly from that of primary cancer. Proper diagnosis of this rare event requires an accurate clinical history, proper immunohistochemical workup, and a high level of suspicion.
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28194627/fragment-based-in-silico-modeling-of-multi-target-inhibitors-against-breast-cancer-related-proteins
#4
Alejandro Speck-Planche, M Natália D S Cordeiro
Breast cancer is the most frequent cancer reported in women, being responsible for hundreds of thousands of deaths. Chemotherapy has proven to be effective against this malignant neoplasm depending on different biological factors such as the histopathology, grade, and stage, among others. However, breast cancer cells have become resistant to current chemotherapeutic regimens, urging the discovery of new anti-breast cancer drugs. Computational approaches have the potential to offer promising alternatives to accelerate the search for potent and versatile anti-breast cancer agents...
February 13, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28192233/use-of-ontology-structure-and-bayesian-models-to-aid-the-crowdsourcing-of-icd-11-sanctioning-rules
#5
Yun Lou, Samson W Tu, Csongor Nyulas, Tania Tudorache, Robert J G Chalmers, Mark A Musen
The International Classification of Diseases (ICD) is the de facto standard international classification for mortality reporting and for many epidemiological, clinical, and financial use cases. The next version of ICD, ICD-11, will be submitted for approval by the World Health Assembly in 2018. Unlike previous versions of ICD, where coders mostly select single codes from pre-enumerated disease and disorder codes, ICD-11 coding will allow extensive use of multiple codes to give more detailed disease descriptions...
February 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28185465/differences-in-incidence-and-biological-characteristics-of-breast-cancer-between-roma-and-non-roma-patients-in-slovakia
#6
M Reckova, J Mardiak, L Plank, M Vulevova, S Cingelová, M Mego
BACKGROUND: Roma (Gypsies) constitute one of the largest ethnic minorities in Slovakia. Some reports have supported a higher prevalence of communicable diseases in Roma but data on cancer prevalence in Roma is absent. The aim of this study was to compare differences in the incidence and pathological characteristics of breast cancer between Roma and non-Roma in Slovakia. PATIENTS AND METHODS: Roma and non-Roma breast cancer patients were identified using the Slovak HER2 Registry...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28185463/-lymphoedema-following-regional-lymph-node-surgery-for-breast-cancer
#7
P Vrtělová, O Coufal, V Fait, L Gabrielová, O Zapletal
BACKGROUND: The treatment of breast cancer is based on the multimodal principle and surgery of regional lymph nodes is an inseparable part of this. Indication criteria are changing constantly folowing advances in other modalities. It is necessary to consider not only the diagnostic or therapeutic benefit but also to take into account adverse effects. Previous studies have demonstrated that axillary dissection (ALND) is burdened by a high frequency of chronic lymphoedema of the arm or chest wall; however, a considerable percentage of patients may also suffer from lymphoedema after sentinel lymph node biopsy (SLNB)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28169866/low-grade-neuroendocrine-carcinoma-of-the-skin-primary-cutaneous-carcinoid-tumor-as-a-distinctive-entity-of-cutaneous-neuroendocrine-tumors-a-clinicopathologic-study-of-3-cases-with-literature-review
#8
Keisuke Goto, Takashi Anan, Takashi Nakatsuka, Yo Kaku, Takaki Sakurai, Takaya Fukumoto, Tetsunori Kimura, Arihiro Shibata
There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Histologically, the tumors showed infiltrating proliferation of nests of various sizes, with low-grade neuroendocrine cytologic features but without mucin production. All cases exhibited varying degrees of intraductal tumor components...
February 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28159233/expression-and-activation-of-platelet-derived-growth-factor-%C3%AE-receptor-mitogen-activated-protein-extracellular-signal-regulated-kinase-kinase-mek-and-extracellular-signal-regulated-kinase-erk-in-canine-mammary-tumours
#9
Gennaro Altamura, Barbara Degli Uberti, Giorgio Galiero, Manuela Martano, Antonella Pirro, Marco Russo, Giuseppe Borzacchiello
Canine mammary tumours are frequent neoplasms mostly affecting intact female dogs, for which no 100% efficient therapy is available. Platelet derived growth factor β receptor (PDGFβR) is a tyrosine kinase receptor (TKR) with a potential role in human breast cancer and a series of canine tumours. In this study we demonstrated, for the first time, expression of PDGFβR and its downstream transduction molecules, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) and extracellular signal-regulated kinase (ERK), as well as their activated forms in canine mammary tumours by both biochemical analysis and immunohistochemistry...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28151718/the-prognostic-role-of-androgen-receptor-in-patients-with-early-stage-breast-cancer-a-meta-analysis-of-clinical-and-gene-expression-data
#10
Ivana Bozovic-Spasojevic, Dimitrios Zardavas, Sylvain Brohée, Lieveke Ameye, Debora Fumagalli, Felipe Ades, Evandro De Azambuja, Yacine Bareche, Martine Piccart, Marianne Paesmans, Christos Sotiriou
: Androgen receptor (AR) expression has been observed in about 70% of breast cancer (BC) patients, but its prognostic role remains uncertain. METHODS: To assess the prognostic role of AR expression in early-stage BC we performed a meta-analysis of studies that evaluated the impact of AR at the protein and gene expression level on disease free survival (DFS) and/or overall survival (OS). Eligible studies were identified by systematic review of electronic databases using the MeSH-terms "breast neoplasm" and "androgen receptor" and were selected after a qualitative assessment based on the REMARK criteria...
November 9, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28143870/early-detection-of-ovarian-cancer-using-the-risk-of-ovarian-cancer-algorithm-with-frequent-ca125-testing-in-women-at-increased-familial-risk-combined-results-from-two-screening-trials
#11
Steven J Skates, Mark H Greene, Saundra S Buys, Phuong L Mai, Powel H Brown, Marion Piedmonte, Gustavo C Rodriguez, John O Schorge, Mark Sherman, Mary B Daly, Thomas J Rutherford, Wendy R Brewster, David M O'Malley, Edward E Partridge, John Boggess, Charles W Drescher, Claudine Isaacs, Andrew Berchuck, Susan M Domchek, Susan A Davidson, Robert P Edwards, Steven A Elg, Katie Wakeley, Kelly-Anne Phillips, Deborah K Armstrong, Ira R Horowitz, Carol J Fabian, Joan Walker, Patrick M Sluss, William R Welch, Lori Minasian, Nora Horick, Carol H Kasten, Susan Nayfield, David S Alberts, Dianne M Finkelstein, Karen Lu
PURPOSE: Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. Research suggests each woman has her own CA125 baseline; significant increases above this level may identify cancers earlier than standard 6-12 monthly CA125>35U/mL. EXPERIMENTAL DESIGN: Data from prospective Cancer Genetics Network and Gynecologic Oncology Group trials, which screened 3,692 women (13,080 woman-screening years) with a strong breast/ovarian cancer family history or BRCA1/2 mutations, were combined to assess a novel screening strategy...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28133311/-a-case-of-appendiceal-mucinous-cystadenoma-treated-using-laparoscopic-appendectomy
#12
Daiki Marukawa, Shingo Noura, Harunobu Yasuyama, Tae Matsumura, Chikato Koga, Akihiro Takata, Chizu Kameda, Masahiro Murakami, Ryohei Kawabata, Masaki Hirota, Junzo Shimizu, Hideaki Miwa, Junichi Hasegawa
A 73 year-old woman who was treated for breast cancer and visited our hospital regularly was suspected of having a mucinous cystadenoma of the appendix. Malignancy could not be determined using abdominal computed tomography, magnetic resonance imaging, or colonoscopy. Even if mucinous cystadenoma is benign, there is the possibility that the tumor will rupture, discharge its contents, and cause pseudomyxoma peritonei. We performed laparoscopic appendectomy. According to the histopathological results, the tumor was diagnosed as a low grade appendiceal mucinous neoplasm...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133014/-a-study-of-therapy-for-locally-advanced-breast-cancer-with-metastasis
#13
Nobuhiko Aoki, Sadao Amano, Masayuki Ando, Akira Fukuda, Katsunori Ami, Kenichiro Imai, Hideaki Ganno, Hirofumi Sugita, Hideaki Amagasa, Kuniyoshi Arai, Shikofumi Tei, Hidetaka Akita
We reviewed 21 patients with locally advanced breast cancer with distant metastasis.The median age was 61 years.The median time to presentation at hospital was 13 months, and the median neoplasm diameter on the first visit was 10 cm.The main histological type was scirrhous carcinoma.Sixteen cases tested positive for hormone receptor(76%), 4 tested positive for HER2(19%), and 3 were triple negative(14%).Four patients underwent surgery.The techniques performed included mastectomy and axillary lymph node dissection...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130560/the-reconstruction-choice-for-giant-phyllodes-tumor-of-breast-bi-pedicled-deep-inferior-epigastric-perforator-flap
#14
Chien-Liang Fang, Chin-Hao Hsu, Chin-Wen Tu
BACKGROUND: Phyllodes tumors of the breast are the rarest of all breast neoplasms. Giant phyllodes tumors (>10 cm) of the breast have been less discussed in the literature. Reconstruction of the large defect created after wide excision (safety margin >1 cm) is a challenge in these patients. We present one technique using a bi-pedicled deep inferior epigastric perforator flap for post-mastectomy breast reconstruction for giant phyllodes tumors. METHODS AND RESULTS: We treated three patients with giant phyllodes tumors between 2013 and 2016...
January 27, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28123524/therapeutic-response-to-a-novel-enzyme-targeting-radiosensitization-treatment-kortuc-ii-for-residual-lesions-in-patients-with-stage-iv-primary-breast-cancer-following-induction-chemotherapy-with-epirubicin-and-cyclophosphamide-or-taxane
#15
Nobutaka Aoyama, Yasuhiro Ogawa, Miki Yasuoka, Hitomi Iwasa, Kana Miyatake, Rika Yoshimatsu, Tomoaki Yamanishi, Norihiko Hamada, Taiji Tamura, Kana Kobayashi, Yoriko Murata, Takuji Yamagami, Mitsuhiko Miyamura
Linac-based radiotherapy has a negligible effect on the majority of advanced neoplasms. Therefore, a novel radiosensitization treatment Kochi Oxydol Radiation Therapy for Unresectable Carcinomas II (KORTUC II), which utilizes hydrogen peroxide and sodium hyaluronate was developed. The effectiveness of KORTUC II for the treatment of chemotherapy-resistant supraclavicular lymph node metastases and recurrent breast cancers has previously been demonstrated. The present study evaluated the safety and efficacy of KORTUC II in patients with stage IV primary breast cancer...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28122281/anti-cancer-effect-of-clofazimine-as-a-single-agent-and-in-combination-with-cisplatin-on-u266-multiple-myeloma-cell-line
#16
İpek Z Durusu, Hazal H Hüsnügil, Heval Ataş, Ayşenur Biber, Selin Gerekçi, Ezgi A Güleç, Can Özen
Multiple Myeloma (MM) is a malignant neoplasm of bone marrow plasma B cells with high morbidity. Clofazimine (CLF) is an FDA-approved leprostatic, anti-tuberculosis, and anti-inflammatory drug that was previously shown to have growth suppression effect on various cancer types such as hepatocellular, lung, cervix, esophageal, colon, and breast cancer as well as melanoma, neuroblastoma, and leukemia. The objective of this study was to evaluate the anticancer effect and mechanism of CLF on U266 MM cell line. CLF (10μM, 24h) treatment resulted up to 72% growth suppression on a panel of hematological cell lines...
January 16, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28120356/understanding-the-role-of-structural-integrity-and-differential-expression-of-integrin-profiling-to-identify-potential-therapeutic-targets-in-breast-cancer
#17
REVIEW
Vishal Das, Gazal Kalyan, Saugata Hazra, Mintu Pal
Breast cancer is found to be the most prevalent neoplasm in women worldwide. Despite the function of physically tethering cells to the matrix, transmembrane protein integrins are crucially involved in diverse cellular functions such as cell differentiation, proliferation, invasion, migration and metastasis. Dysregulation of integrins and their interactions with the cells and their microenvironment can trigger several signalling cues that determine the cell fate decision. In this review we spotlight all pre-existing integrin molecules, their structure, molecular interactions motifs, and function through several cross talks with kinase receptors...
January 24, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28118820/primary-neuroendocrine-breast-carcinomas-are-associated-with-poor-local-control-despite-favourable-biological-profile-a-retrospective-clinical-study
#18
Nelli Roininen, Sari Takala, Kirsi-Maria Haapasaari, Arja Jukkola-Vuorinen, Johanna Mattson, Päivi Heikkilä, Peeter Karihtala
BACKGROUND: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. METHODS: We collected retrospectively patients with NEBC from Oulu and Helsinki University Hospitals in 2007-2015. There were 43 NEBC cases during the period. RESULTS: The incidence of NEBC from all breast cancers varied from 0...
January 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28099969/digital-ischemia-as-a-paraneoplastic-phenomenon
#19
Tatiana Rodrigues, Anabela Barcelos
Digital ischemia is a rare paraneoplastic phenomenon associated with several malignant tumours, particularly adenocarcinomas. The underlying pathogenic mechanisms remain unknown and it can be the first manifestation, occur after the diagnosis or during treatment. We report a case of a 50 year old woman presenting with digital ischemia, whose diagnostic workup led to an invasive breast cancer, with significant improvement of digital ischemia after a successful treatment of the neoplasm.
October 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28099545/cutaneous-adnexal-carcinoma-with-apocrine-differentiation
#20
Vikram Prasad, Wynn H Kao, Grace F Kao
Primary cutaneous apocrine carcinomas are uncommon malignant neoplasms that can be difficult, if not impossible, to distinguish histologically from metastatic breast carcinomas. We present the case of a 71-year-old man with a 5-year history of extensive ulcerated plaques on the posterior neck and posterior scalp. Biopsy revealed a poorly differentiated infiltrating adenocarcinoma consistent with either primary cutaneous apocrine carcinoma or occult metastatic breast carcinoma. Immunohistochemical analysis demonstrated positive staining for cytokeratin (CK) 7, estrogen receptor, and progesterone receptor, and negative staining for p63, podoplanin, CK20, and thyroid transcription factor 1...
December 2016: Cutis; Cutaneous Medicine for the Practitioner
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