keyword
https://read.qxmd.com/read/38536543/effect-of-early-dose-reduction-of-osimertinib-on-efficacy-in-the-first-line-treatment-for-egfr-mutated-non-small-cell-lung-cancer
#1
JOURNAL ARTICLE
Tomoki Hori, Kazuhiro Yamamoto, Takefumi Ito, Shigeki Ikushima, Tomohiro Omura, Ikuko Yano
Osimertinib is used as the first-line therapy for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, early dose reduction is often required due to adverse events (AEs). This study aimed to evaluate the effect of early dose reduction of osimertinib on efficacy and safety. This was a retrospective study including patients with EGFR-mutated NSCLC who were started on osimertinib as the first-line therapy between August 2018 and December 2021. Patients whose doses were reduced to less than 80 mg/day within 6 months of osimertinib initiation or started at 40 mg/day were defined as the dose reduction group...
March 27, 2024: Investigational New Drugs
https://read.qxmd.com/read/38535053/a-web-based-dynamic-nomogram-to-predict-the-risk-of-methicillin-resistant-staphylococcal-infection-in-patients-with-pneumonia
#2
JOURNAL ARTICLE
Van Duong-Thi-Thanh, Binh Truong-Quang, Phu Tran-Nguyen-Trong, Mai Le-Phuong, Phu Truong-Thien, Dung Lam-Quoc, Thong Dang-Vu, Minh-Loi Nguyen, Vu Le-Thuong
The aim of this study was to create a dynamic web-based tool to predict the risks of methicillin-resistant Staphylococcus spp. (MRS) infection in patients with pneumonia. We conducted an observational study of patients with pneumonia at Cho Ray Hospital from March 2021 to March 2023. The Bayesian model averaging method and stepwise selection were applied to identify different sets of independent predictors. The final model was internally validated using the bootstrap method. We used receiver operator characteristic (ROC) curve, calibration, and decision curve analyses to assess the nomogram model's predictive performance...
March 16, 2024: Diagnostics
https://read.qxmd.com/read/38534990/safety-and-diagnostic-yield-of-medical-pleuroscopy-mp-performed-under-balanced-analgosedation-by-a-pneumological-team-compared-to-video-assisted-thoracic-surgery-vats-a-retrospective-controlled-real-life-study-torapo
#3
JOURNAL ARTICLE
Valentino Allocca, Luca Guidelli, Angela Galgano, Lucia Benedetti, Roberto Fabbroni, Andrea Bianco, Piero Paladini, Raffaele Scala
INTRODUCTION: Medical pleuroscopy (MP) is an invasive technique that provides access to the pleural space with a rigid or semi-rigid work instrument, allowing for visualization and the obtaining of bioptic pleural samples. Using pulmonologist-based analgosedation to perform pleuroscopy is still debated for safety reasons. The aim of this real-life study is to demonstrate the safety and diagnostic yield of MP performed under balanced analgosedation by a pulmonologist team with expertise in the management of critically ill patients in the respiratory intensive care unit (RICU) and interventional pulmonology unit as compared to video-assisted thoracic surgery (VATS) performed by a thoracic surgeon team under anesthesiologist-based analgosedation...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38529671/pleural-fluid-characteristics-of-patients-with-covid-19-infection
#4
JOURNAL ARTICLE
Ryan A Denu, Victoria Forth, Majid Shafiq
INTRODUCTION: Pleural effusions are known to occur in many cases of COVID-19. Data on typical characteristics of COVID-19-associated pleural effusions are limited. The goal of this project was to characterize the pleural fluid from patients with COVID-19. METHODS: We retrospectively collected electronic medical record data from adults hospitalized at a large metropolitan hospital system with COVID-19 infection who had a pleural effusion and a thoracentesis performed...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529577/comparative-analysis-of-ct-findings-and-clinical-outcomes-in-adult-patients-with-disseminated-and-localized-pulmonary-nocardiosis
#5
JOURNAL ARTICLE
Han Na Lee, Kyung-Hyun Do, Eun Young Kim, Jooae Choe, Heungsup Sung, Sang-Ho Choi, Hwa Jung Kim
BACKGROUND: Pulmonary nocardiosis is a rare opportunistic infection with occasional systemic dissemination. This study aimed to investigate the computed tomography (CT) findings and prognosis of pulmonary nocardiosis associated with dissemination. METHODS: We conducted a retrospective analysis of patients diagnosed with pulmonary nocardiosis between March 2001 and September 2023. We reviewed the chest CT findings and categorized them based on the dominant CT findings as consolidation, nodules and/or masses, consolidation with multiple nodules, and nodular bronchiectasis...
March 25, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38529443/multiple-myeloma-a-rare-presentation-as-unilateral-pleural-effusion
#6
Kalyani Deshmukh, Kajal Hatgoankar, Milind Pande, Parag Sabale, Nandkishor J Bankar
Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells in the bone marrow. It commonly presents with bone pain, anemia, renal failure, and hypercalcemia. Pleural effusion in MM usually has multiple causes, but it is rare for the effusion to be due to myelomatous deposition of the pleura. Here, we present a rare case in which the patient presented to the outpatient department with a dry cough, breathlessness, and generalized weakness. The patient was diagnosed with MM with myelomatous pleural effusion (MPE), highlighting the importance of considering MM as a differential diagnosis in patients with atypical presentations...
February 2024: Curēus
https://read.qxmd.com/read/38529375/case-report-a-case-of-metastatic-brafv600-mutated-melanoma-with-heart-failure-treated-with-immune-checkpoint-inhibitors-and-braf-mek-inhibitors
#7
Aya Nishizawa, Misaki Kawakami, Yasuyuki Kitahara
BACKGROUND: Novel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK inhibitors (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic for both agents and, although rare, can cause serious cardiac dysfunction. CASE REPORT: A 42-year-old male patient with no significant medical history noticed a fading dark brown patch on his left anterior chest, which had been there for 20 years, after his second coronavirus disease 2019 (COVID-19) vaccination...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38528948/utilizing-medical-thoracoscopy-for-the-diagnosis-of-myelomatous-pleural-effusion-2-case-reports
#8
Khai Lip Ng, Sin Nee Tan, Nai-Chien Huan, Mona Zaria Nasaruddin, Noriah Othman, Jamalul Azizi Abdul Rahaman
Multiple myeloma (MM) is characterized by neoplastic proliferation of monoclonal antibody producing plasma cells. In clinical practice, pleural effusion is seen in up to 6% of MM patients, with many causative factors. Nevertheless, true myelomatous pleural effusion, defined as infiltration of the pleura by myeloma cells, is very rare. In this case report, we present two patients with biopsy proven myelomatous pleural effusion. The first patient developed myelomatous pleural effusion as initial presentation while the second patient's pleural effusion occurred during disease relapse...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38528947/massive-pleural-effusion-in-porous-diaphragm-syndrome-due-to-lymphatic-leakage-after-pelvic-surgery
#9
Masashi Nishimura, Takunori Ogawa, Tomomi Tanigaki, Koji Sumi, Yasuhiro Enjoji, Yohsuke Suyama, Akihiko Kawana, Yoshifumi Kimizuka
We present the case of a patient who developed a massive right pleural effusion after pelvic surgery, not thoracic surgery. Lymphatic leakage into the abdominal cavity after pelvic surgery can cause massive pleural effusion when complicated with porous diaphragm syndrome.
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38528938/real-time-ultrasound-guided-thoracentesis-simulation-using-an-optical-see-through-head-mounted-display-a-proof-of-concept-study
#10
JOURNAL ARTICLE
Shotaro Okachi, Toshinori Matsui, Manami Sakurai, Takayasu Ito, Masahiro Morise, Kazuyoshi Imaizumi, Makoto Ishii, Michitaka Fujiwara
AIM: This study aimed to examine the feasibility and potential benefits of an optical see-through head-mounted display (OST-HMD) during real-time ultrasound-guided thoracentesis simulations. MATERIAL AND METHODS: Six physicians performed a thoracentesis simulation using an OST-HMD and a wireless image transmission system. The time required, puncture needle visibility, pleural fluid collection success rate, and head movement during the procedure using a smart glass equipped with an inertial measurement unit were all recorded and compared with and without the HMD...
February 2024: Journal of Ultrasonography
https://read.qxmd.com/read/38527503/-the-diagnostic-value-of-lung-ultrasound-in-children-with-community-acquired-pneumonia
#11
JOURNAL ARTICLE
S J Cai, L L Zhang, S Y Chen, T T Zhu, M Xu, Y M Zheng, H L Zhang
Objective: To investigate the diagnostic value of lung ultrasound in hospitalized children with community-acquired pneumonia (CAP). Methods: In the cross-sectional study, a total of 422 children with CAP who were hospitalized in the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, from February 2021 to August 2022 and completed lung ultrasound examination within 48 hours after admission were enrolled. The clinical characteristics, lung ultrasound and chest CT were collected...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38527273/a-65-year-old-man-with-refractory-hemoptysis-associated-with-chronic-progressive-pulmonary-aspergillosis-who-failed-to-respond-to-combined-endobronchial-occlusion-and-bronchial-artery-embolization-a-case-report-and-literature-review
#12
REVIEW
Ryotaro Yoneoka, Kenichiro Takeda, Hajime Kasai, Toshihiko Sugiura, Kohei Shikano, Mitsuhiro Abe, Takuji Suzuki
BACKGROUND Hemoptysis due to airway hemorrhage is treated with hemostatic agents, bronchial artery embolization (BAE), or surgical resection. We present the case of a 65-year-old man with refractory hemoptysis associated with chronic progressive pulmonary aspergillosis (CPPA) who failed to respond to combined endobronchial occlusion (EBO) with endobronchial Watanabe spigot (EWS) and BAE. CASE REPORT A 63-year-old man was diagnosed with CPPA in the right upper lung and presented to our hospital 2 years later for hemoptysis at age 65...
March 13, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38526466/postoperative-pulmonary-complications-in-patients-undergoing-upper-abdominal-surgery-risk-factors-and-predictive-models
#13
JOURNAL ARTICLE
Shivam Garg, Vishnukanth Govindaraj, Dharm Prakash Dwivedi, Kalayarasan Raja, Elamurugan Palanivel Theerthar
Postoperative pulmonary complications (PPCs) are unexpected disorders that occur up to 30 days after surgery, affecting the patient's clinical status and requiring therapeutic intervention. Therefore, it becomes important to assess the patient preoperatively, as many of these complications can be minimized with proper perioperative strategies following a thorough preoperative checkup. Herein, we describe the PPCs and risk factors associated with developing PPCs in patients undergoing upper abdominal surgery...
March 25, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38524505/delayed-neurological-dysfunction-following-posterior-laminectomy-with-lateral-mass-screw-fixation-a-case-report-and-review-of-literature
#14
Rui-Zhong Yan, Chao Chen, Chu-Ran Lin, Yan-Hui Wei, Zhi-Jian Guo, Ya-Kun Li, Quan Zhang, He-Yi Shen, Hao-Lin Sun
BACKGROUND: While most complications of cervical surgery are reversible, some, such as symptomatic postoperative spinal epidural hematoma (SEH), which generally occurs within 24 h, are associated with increased morbidity and mortality. Delayed neurological dysfunction is diagnosed in cases when symptoms present > 3 d postoperatively. Owing to its rarity, the risk factors for delayed neurological dysfunction are unclear. Consequently, this condition can result in irreversible neurological deficits and serious consequences...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38523983/rapid-progression-of-aortitis-caused-by-methicillin-sensitive-staphylococcus-aureus-in-a-patient-with-pneumonia-a-case-report
#15
Hideya Itagaki, Tomoya Ooizumi, Chiho Sanada, Yoshinobu Abe, Tomoyuki Endo
Infected aortic aneurysm is a rare but fatal disease that occurs through various mechanisms. In this report, we describe the case of a patient who was hospitalized for acute pneumonia and developed an infected aortic aneurysm in the descending aorta during the hospitalization. A 73-year-old Japanese man presented to the emergency department with a chief complaint of fever. He had a history of chronic renal failure due to nephrosclerosis and was on regular hemodialysis three times a week. The patient presented with an elevated inflammatory response, anemia, and low platelet counts after various tests...
February 2024: Curēus
https://read.qxmd.com/read/38523926/pseudo-meigs-syndrome-with-eosinophilic-pleural-effusion
#16
Masafumi Shimoda, Yoshiaki Tanaka, Kozo Morimoto, Iori Moue, Ken Ohta
We present a rare case of a 45-year-old woman with pseudo-Meigs' syndrome and eosinophilic pleural effusion (EPE). She experienced cough, sputum, and dyspnea with a large right pleural effusion. Laboratory tests showed eosinophilia in the blood and pleural fluid. An ovarian tumor and ascites were also detected. After left salpingo-oophorectomy, the tumor was diagnosed as a mature cystic teratoma of the left ovary. The right-sided pleural effusion gradually resolved. Pseudo-Meigs' syndrome is characterized by benign ovarian tumor, ascites, and pleural effusion...
February 2024: Curēus
https://read.qxmd.com/read/38523886/efficacy-and-safety-of-peroral-endoscopic-myotomy-poem-in-achalasia-an-updated-meta-analysis
#17
JOURNAL ARTICLE
Afshin Khaiser, Muhammad Baig, David Forcione, Matthew Bechtold, Srinivas R Puli
Background: Heller myotomy has been considered the standard surgical treatment for patients with achalasia. Since the initiation of peroral endoscopic myotomy (POEM), it has represented an alternative for treating patients with achalasia. Over the years, numerous prospective and retrospective studies with POEM use for achalasia have been published. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of POEM in patients with achalasia. Methods: Publications investigating the safety and efficacy of POEM in patients with achalasia were searched in Medline, Ovid Journals, Medline non-indexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523603/clinical-outcome-of-bevacizumab-or-ramucirumab-combined-with-epidermal-growth-factor-receptor-egfr-tyrosine-kinase-inhibitors-as-the-first-line-therapy-in-susceptible-egfr-mutated-advanced-non-small-cell-lung
#18
JOURNAL ARTICLE
Chia-Yu Kuo, Ming-Ju Tsai, Jen-Yu Hung, Mei-Hsuan Lee, Kuan-Li Wu, Yu-Chen Tsai, Cheng-Hao Chuang, Chung-Wen Huang, Chin-Ling Chen, Chih-Jen Yang, Inn-Wen Chong
Combining epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an anti- vascular endothelial growth factor (VEGF) agent, bevacizumab or ramucirumab, is indicated for advanced lung adenocarcinoma harboring EGFR mutation. This study aimed to show the real-world data of combination therapy and compare the effectiveness between bevacizumab and ramucirumab in combination with an EGFR-TKI. This retrospective study enrolled 47 patients diagnosed of stage IV lung adenocarcinoma with exon 19 deletion or L858R point mutation, receiving a first-line EGFR-TKI with anti-VEGF agent, including 34 (72%) and 13 (28%) patients receiving bevacizumab and ramucirumab, respectively...
March 25, 2024: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/38522906/effect-of-thyrocervical-artery-embolization-for-mediastinal-hemangioma-with-pleural-effusion
#19
JOURNAL ARTICLE
Kazuya Kojima, Kyoko Yagyu, Haruhiko Matsushita, Katsuyasu Ota
A 72-year-old man was admitted to our hospital with a complaint of breathlessness. Computed tomography (CT) revealed a tumor with intense early enhancement and pleural effusion. Although the pleural effusion was not bloody, the tumor showed a hypervascular area on angiography. Left thyrocervical artery embolization was performed to prevent bleeding during the operation. After embolization, chest radiography revealed decreased pleural effusion. The tumor was resected and pathologically diagnosed as a mediastinal cavernous hemangioma...
March 25, 2024: Internal Medicine
https://read.qxmd.com/read/38520909/ex-vivo-drug-testing-of-patient-derived-lung-organoids-to-predict-treatment-responses-for-personalized-medicine
#20
REVIEW
Josephine A Taverna, Chia-Nung Hung, Madison Williams, Ryan Williams, Meizhen Chen, Samaneh Kamali, Vaishnavi Sambandam, Cheryl Hsiang-Ling Chiu, Pawel A Osmulski, Maria E Gaczynska, Daniel T DeArmond, Christine Gaspard, Maria Mancini, Meena Kusi, Abhishek N Pandya, Lina Song, Lingtao Jin, Paolo Schiavini, Chun-Liang Chen
Lung cancer is the leading cause of global cancer-related mortality resulting in ∼ 1.8 million deaths annually. Systemic, molecular targeted, and immune therapies have provided significant improvements of survival outcomes for patients. However, drug resistance usually arises and there is an urgent need for novel therapy screening and personalized medicine. 3D patient-derived organoid (PDO) models have emerged as a more effective and efficient alternative for ex vivo drug screening than 2D cell culture and patient-derived xenograft (PDX) models...
March 14, 2024: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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