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Pleural effusions

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https://www.readbyqxmd.com/read/30005083/prognostic-value-of-platelet-count-and-lymphocyte-to-monocyte-ratio-combination-in-stage-iv-non-small-cell-lung-cancer-with-malignant-pleural-effusion
#1
Jeong Uk Lim, Chang Dong Yeo, Hye Seon Kang, Chan Kwon Park, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee
INTRODUCTION: A combination of platelet and lymphocyte to monocyte ratio (LMR) (abbreviated as COP-LMR) has been recently evaluated as systemic inflammatory marker for prognostication in lung cancer. While previous study on COP-LMR has evaluated its prognostic value in NSCLC patients who underwent curative resections, the combination of these two markers has not been evaluated in advanced NSCLC yet. OBJECTIVES: In this study, we evaluated the prognostic value of COP-LMR in stage IV NSCLC with malignant pleural effusion under active anticancer treatment...
2018: PloS One
https://www.readbyqxmd.com/read/30004629/what-is-the-significance-of-non-specific-pleuritis-a-trick-question
#2
Julius Janssen, Fabien Maldonado, Muzaffer Metintas
Non-specific pleuritis (NSP) is defined as fibrinous or inflammatory pleuritis which cannot be attributed to a specific benign or malignant etiology. It can be diagnosed in biopsies in up to 30% of cases of exudative pleuritis after thoracoscopy, with a mean of 19.2%. In 66 out of 469 (14.2%) patients in combined series, a malignant pleural disease (mostly mesothelioma) was found during a follow-up of at least 21 months. Most likely, a follow-up time of 12 months is sufficient, although the current routine is a follow-up of 2 years...
July 13, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/30003096/risk-factors-related-to-peripherally-inserted-central-venous-catheter-nonselective-removal-in-neonates
#3
Xiaohe Yu, Shaojie Yue, Mingjie Wang, Chuanding Cao, Zhengchang Liao, Ying Ding, Jia Huang, Wen Li
We aimed to investigate the incidence and risk factors associated with nonselective removal of peripherally inserted central venous catheter (PICC) in neonates. In this prospective cohort study, neonates who underwent PICC placement at neonatal intensive care units (NICUs) in China from October 2012 to November 2015 were included. The patient demographics, catheter characteristics, catheter duration, PICC insertion site, indication for PICC insertion, infuscate composition, PICC tip location, and catheter complications were recorded in a computerized database...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29998377/impact-of-nesiritide-infusion-on-early-postoperative-recovery-after-total-cavopulmonary-connection-surgery
#4
Yajuan Zhang, Yabing Duan, Jun Yan, Qiang Wang, Shoujun Li, Haitao Xu
OBJECTIVE: The purpose of the study is to compare the effects of nesiritide on the discharge time and pleural effusion in children with total cavopulmonary connection (TCPC), and to provide a more reasonable clinical method for these children. METHODS: Forty-four who children underwent cavopulmonary connection between January 2016 and 2017 were retrospectively collected, and 5 children were excluded from analysis due to postoperative thrombosis or second Fontan surgery due to high pulmonary hypertension...
July 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29997996/non-pyothorax-associated-primary-pleural-lymphoma-without-pleural-effusion-in-an-immunocompetent-patient-a-case-report-and-literature-review
#5
Chuan Shao, Yongwei Guo, Xianfa Xu, Deng Pan, Bijiong Wang, Yaodong Tang, Shuguang Xu
No abstract text is available yet for this article.
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997989/carcinoembryonic-antigen-positive-pleural-effusion-in-early-stage-non-small-cell-lung-cancer-without-pleural-infiltration
#6
Njanja Enz, Fernando Fragoso, Alexander Gamrekeli, Frank Lippek, Wolfgang Jungraithmayr
Carcinoembryonic antigen (CEA) is a tumor marker for detecting recurrences of adenocarcinomas such as colon cancer. In lung adenocarcinoma, CEA elevation can be found in both serum and malignant pleural effusion. However, CEA elevation in cytologically negative pleural effusion in the presence of adenocarcinoma without pleural infiltration has not been described. We here present the case of an 82-year-old man with incidental early stage adenocarcinoma of the right upper lobe showing CEA elevation in pleural fluid and serum despite negative cytological findings...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997967/pleural-catheters-after-thoracoscopic-treatment-of-malignant-pleural-effusion-a-randomized-comparative-study-on-quality-of-life
#7
Francesco Petrella, Patrick Maisonneuve, Alessandro Borri, Monica Casiraghi, Stefano Donghi, Sava Durkovic, Niccolo Filippi, Domenico Galetta, Roberto Gasparri, Juliana Guarize, Giorgio Lo Iacono, Alessio Vincenzo Mariolo, Adele Tessitore, Lorenzo Spaggiari
Background: Malignant pleural effusion (MPE) complicates many neoplasms and its incidence is expected to rise in parallel with the aging population and longer survival of cancer patients. Although a clear consensus exists on indwelling catheters in patients with poor performance status, no study has hitherto compared different devices in patients requiring temporary or definitive drainage following talc poudrage. Methods: This is a prospective, two-arm, pilot study on patients with MPE undergoing talc poudrage, comparing two different catheters (PleurX® versus Pleurocath® ) positioned because of the inefficacy of the procedure or the high risk of short-term failure...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997964/a-comparison-between-two-types-of-indwelling-pleural-catheters-for-management-of-malignant-pleural-effusions
#8
Sushilkumar Satish Gupta, Charalampos S Floudas, Abhinav B Chandra
Background: Malignant pleural effusion (MPE) is a common cause of quality of life deterioration in patients with advanced cancer. Management options include chemical pleurodesis with a sclerosing agent such as doxycycline or talc powder, surgery, and also the placement of tunneled indwelling pleural catheters (IPCs). Two different IPC types are mostly used in the USA. Methods: We conducted a single-center retrospective study with the objective to compare the efficacy and safety profiles of two IPC systems...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997924/next-generation-sequencing-based-molecular-profiling-of-lung-adenocarcinoma-using-pleural-effusion-specimens
#9
Liping Liu, Di Shao, Qiuhua Deng, Hailing Tang, Jingjing Wang, Jilong Liu, Fengming Guo, Yongping Lin, Zhiyu Peng, Mao Mao, Karsten Kristiansen, Mingzhi Ye, Jianxing He
Background: Molecular profiling of non-small cell lung cancer (NSCLC) is essential for therapeutic decision-making. Pleural effusion obtained by a non-invasive, repeatable procedure may provide an opportunity for molecular profiling and thereby possibly provide information enabling targeted therapy. In this study, we aimed to evaluate the diagnostic performance of pleural effusion as a specimen for molecular analysis. Methods: Thirty patients with paired malignant pleural effusion and thoracic biopsy specimens were included...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997916/calpain-and-spectrin-breakdown-products-as-potential-biomarkers-in-tuberculous-pleural-effusion
#10
Ji Young Hong, So Yeong Park, Youngmi Kim, Chang Youl Lee, Myung Goo Lee
Background: Early diagnosis of tuberculous pleural effusion (TPE) remains difficult. Calpain is a family of calcium-dependent endopeptidase that plays an important role in extracellular matrix (ECM) remodeling and collagen synthesis. The aim of this study was to explore the diagnostic value of pleural fluid angiotensin-converting enzyme (ACE), calpain-1, spectrin breakdown products (SBDP), and matrix metalloproteinase-1 (MMP-1) in TPE and malignant pleural effusion (MPE). Methods: The study included 47 patients with TPE, 28 patients with MPE, and 10 patients with transudate of non-tuberculous and non-malignant origin as controls...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29996034/refractory-hepatic-hydrothorax-in-the-absence-of-ascites-as-a-first-sign-of-cirrhosis
#11
Khalil Aloreidi, Maheedhar Gedela, Godfrey Wabwire, Uma M Mothapothula, Lokesh Jha
Hepatic hydrothorax (HH) occurs in 5-10 percent of patients with cirrhosis and usually develops in conjunction with ascites. We report a case of refractory right sided pleural effusion which turned out to be HH in the absence of ascites or previous history of cirrhosis. HH is thought to occur in isolation due to the superior absorptive capacity of the peritoneum as compared to the pleura. Diagnosis is usually clinical but can be confirmed by scintigraphic studies. The treatment is similar to that for ascites with transjugular intrahepatic portosystemic shunt (TIPS) being the most effective but it is associated with high rate of complications...
April 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29995776/outcome-of-adult-t-lymphoblastic-lymphoma-depends-on-all-type-chemotherapy-prognostic-factors-and-performance-of-allogeneic-hematopoietic-stem-cell-transplantation
#12
Meiwei Hu, Huafeng Wang, Lei Wang, Min Yang, Yinjun Lou, Jie Jin
To study the prognostic factors of adult patients with T-lymphoblastic lymphoma (T-LBL) and to evaluate therapeutic effects of acute lymphoblastic leukemia (ALL)-type chemotherapy in combination with allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients who achieved overall response (OR) with first line ALL-type chemotherapy.This was a retrospective study of 59 adult patients with T-LBL treated with hyper-fractionated administration of cyclophosphamide, vincristine, doxorubicin and dexamethasone/methotrexate (hyper-CVAD/MA) chemotherapy alone or in combination with allo-HSCT between June 2008 and October 2015...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29995433/a-multivariable-prediction-model-for-pneumocystis-jirovecii-pneumonia-in-hematology-patients-with-acute-respiratory-failure
#13
Elie Azoulay, Antoine Roux, François Vincent, Achille Kouatchet, Laurent Argaud, Antoine Rabbat, Julien Mayaux, Pierre Perez, Frédéric Pène, Martine Nyunga, Fabrice Bruneel, Kada Klouche, Djamel Mokart, Michael Darmon, Sylvie Chevret, Virginie Lemiale
RATIONALE: The incidence of Pneumocystis jirovecii pneumonia (PjP) is rising. Longer time to treatment is associated with higher mortality. OBJECTIVES: to develop a multivariable risk prediction model for PjP diagnosis. METHODS: In a prospective multicentre cohort of intensive-care-unit patients with hematological malignancies and ARF, factors associated with documented PjP were identified. The risk prediction model was tested in an independent prospective multicentre cohort...
July 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29989040/an-exploratory-study-of-daprodustat-in-erythropoietin-hyporesponsive-subjects
#14
Borut Cizman, Andy P Sykes, Gitanjali Paul, Steven Zeig, Alexander R Cobitz
Introduction: Hyporesponsiveness to recombinant human erythropoietin (rhEPO) is a major problem affecting some patients with chronic kidney disease (CKD), predominantly those on hemodialysis (HD). Daprodustat (GSK1278863) is a hypoxia-inducible factor prolyl hydroxylase inhibitor that is being investigated as a treatment for anemia of CKD. Methods: This phase 2a, exploratory, multicenter, single-arm study assessed the ability of daprodustat to increase or maintain hemoglobin concentrations within the target range (10...
July 2018: KI Reports
https://www.readbyqxmd.com/read/29988633/pulmonary-pleomorphic-carcinoma-with-pseudoprogression-during-nivolumab-therapy-and-the-usefulness-of-tumor-markers-a-case-report
#15
Akihiro Yoshimura, Chieko Takumi, Taisuke Tsuji, Ryosuke Hamashima, Shinsuke Shiotsu, Tatsuya Yuba, Yoji Urata, Noriya Hiraoka
Pseudoprogression was reported as one of the unconventional responses during immune checkpoint inhibitor therapy. A 70-year-old man with pulmonary pleomorphic carcinoma received nivolumab therapy. Pleural effusion and pulmonary metastasis increased, however then shrank and serum cytokeratin 19 fragment levels decreased. Serum tumor marker might help to distinguish pseudoprogression.
July 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29984774/a-case-of-lung-cancer-with-a-small-cell-carcinoma-component-diagnosed-from-pleural-effusion-and-a-squamous-cell-carcinoma-component-diagnosed-from-the-tumor
#16
Yoshiaki Zaizen, Takaaki Tokito, Ken Masuda, Koichi Azuma, Yoshiki Naito, Shingo Tsuneyoshi, Yuki Sakzaki, Norikazu Matsuo, Hidenobu Ishii, Kazuhiko Yamada, Jun Akiba, Tomoaki Hoshino
There have been few reports on the accuracy of the diagnosis of small-cell carcinoma based on a cytological examination of malignant pleural effusion, so whether or not such a diagnosis is possible using this approach alone remains unclear. We herein report a 76-year-old Japanese man in whom small-cell carcinoma was diagnosed cytopathologically from pleural effusion and squamous cell carcinoma was diagnosed histopathologically from a transbronchial biopsy. Tumor shrinkage was achieved by treatment with docetaxel, but the efficacy of carboplatin plus etoposide was inadequate...
July 6, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29984771/progressive-encephalomyelitis-with-rigidity-and-myoclonus-resolving-after-thymectomy-with-subsequent-anasarca-an-autopsy-case
#17
Kokoro Ozaki, Takuya Ohkubo, Tetsuo Yamada, Kotaro Yoshioka, Masahiko Ichijo, Takamasa Majima, Shunsuke Kudo, Takumi Akashi, Keiji Honda, Eisaku Ito, Mayumi Watanabe, Masaki Sekine, Miwako Hamagaki, Yoshinobu Eishi, Nobuo Sanjo, Satoru Ishibashi, Hidehiro Mizusawa, Takanori Yokota
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is an autoimmune disorder involving the brainstem and spinal cord and is sometimes associated with thymoma. We encountered a 75-year-old woman with typical PERM features, glycine receptor antibody, and thymoma. Her neurologic symptoms improved after thymectomy, but she unexpectedly developed anasarca with massive pleural effusions and hypoalbuminemia and finally succumbed to death. The autopsy showed edema and mononuclear infiltration in the pleura but no neuropathological findings typical of PERM...
July 6, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29984031/diffuse-alveolar-hemorrhage-induced-by-vaping
#18
Michael Agustin, Michele Yamamoto, Felix Cabrera, Ricardo Eusebio
There has been a significant increase in electronic cigarette (e-cigarette) use since its introduction in 2007. Ironically, there remains very few published literature on the respiratory complications of e-cigarettes. The use of personalized vaporizers or commonly known as "vaping" has started to overtake standard e-cigarette. Its dynamic vaporizer customization makes it challenging to assess long-term health effects. Case reports on the pulmonary complications of e-cigarettes are limited to bronchiectasis, eosinophilic pneumonia, pleural effusion, and suspected hypersensitivity pneumonitis...
2018: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29980186/thoracic-injection-of-low-dose-interleukin-2-as-an-adjuvant-therapy-improves-the-control-of-the-malignant-pleural-effusions-a-systematic-review-and-meta-analysis-base-on-chinese-patients
#19
Liping Han, Qiufang Jiang, Wei Yao, Tian Fu, Qingdi Zeng
BACKGROUND: Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treating malignant pleural effusion (MPE) through thoracic injection. METHODS: We searched these studies from medical electronic database. A total of 18 studies that met the inclusion criteria were recruited in this meta-analysis. Pooled odds ratios (OR) with 95% confidence intervals (CI) were determined by the fixed effects model of meta-analysis...
July 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29978949/well-controlled-pleural-effusion-indicated-pseudoprogression-after-immunotherapy-in-lung-cancer-a-case-report
#20
Guihong Liu, Tao Chen, Ronghui Li, Li Zhu, Dingyi Liu, Zhenyu Ding
Squamous cancer (SqCC) of the lung has a poor prognosis. With the advent of immunotherapy, prognosis has tended to improve; however, pseudoprogression poses a challenge to the management of immunotherapy. Herein, we discuss the case of a 47-year-old heavy smoker with advanced SqCC. The patient had recurrent disease after initial successful control of the tumor by concurrent radiochemotherapy, together with ample pleural effusion. Pleural effusion was well controlled with systematic nivolumab and intra-thoracic recombinant endostatin; however with simultaneous deterioration of performance and tumor progression...
July 6, 2018: Thoracic Cancer
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