keyword
MENU ▼
Read by QxMD icon Read
search

DOAK

keyword
https://www.readbyqxmd.com/read/28280722/tissue-engineered-solutions-in-plastic-and-reconstructive-surgery-principles-and-practice
#1
REVIEW
Sarah Al-Himdani, Zita M Jessop, Ayesha Al-Sabah, Emman Combellack, Amel Ibrahim, Shareen H Doak, Andrew M Hart, Charles W Archer, Catherine A Thornton, Iain S Whitaker
Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28231421/varying-demographic-impacts-of-different-fisheries-on-three-mediterranean-seabird-species
#2
M Genovart, D Doak, J M Igual, S Sponza, J Kralj, D Oro
Fisheries have an enormous economic importance but reconciling their socio-economic features with the conservation and sustainability of marine ecosystems presents major challenges. Bycatch mortality from fisheries is clearly among the most serious global threats for marine ecosystems, affecting a wide range of top predators. Recent estimates report ca. 200,000 seabirds killed annually by bycatch in European waters. However there is an urgent need to rigorously estimate actual mortality rates and quantify effects of bycatch on populations...
February 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28204679/population-genomics-of-paramecium-species
#3
Parul Johri, Sascha Krenek, K Marinov, Thomas G Doak, Thomas U Berendonk, Michael Lynch
No abstract text is available yet for this article.
February 13, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28202732/atomic-structure-of-granulin-determined-from-native-nanocrystalline-granulovirus-using-an-x-ray-free-electron-laser
#4
Cornelius Gati, Dominik Oberthuer, Oleksandr Yefanov, Richard D Bunker, Francesco Stellato, Elaine Chiu, Shin-Mei Yeh, Andrew Aquila, Shibom Basu, Richard Bean, Kenneth R Beyerlein, Sabine Botha, Sébastien Boutet, Daniel P DePonte, R Bruce Doak, Raimund Fromme, Lorenzo Galli, Ingo Grotjohann, Daniel R James, Christopher Kupitz, Lukas Lomb, Marc Messerschmidt, Karol Nass, Kimberly Rendek, Robert L Shoeman, Dingjie Wang, Uwe Weierstall, Thomas A White, Garth J Williams, Nadia A Zatsepin, Petra Fromme, John C H Spence, Kenneth N Goldie, Johannes A Jehle, Peter Metcalf, Anton Barty, Henry N Chapman
To understand how molecules function in biological systems, new methods are required to obtain atomic resolution structures from biological material under physiological conditions. Intense femtosecond-duration pulses from X-ray free-electron lasers (XFELs) can outrun most damage processes, vastly increasing the tolerable dose before the specimen is destroyed. This in turn allows structure determination from crystals much smaller and more radiation sensitive than previously considered possible, allowing data collection from room temperature structures and avoiding structural changes due to cooling...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28112402/portfolio-effects-climate-change-and-the-persistence-of-small-populations-analyses-on-the-rare-plant-saussurea-weberi
#5
Ronald E Abbott, Daniel F Doak, Megan L Peterson
The mechanisms that stabilize small populations in the face of environmental variation are crucial to their long-term persistence. Building from diversity-stability concepts in community ecology, within-population diversity is gaining attention as an important component of population stability. Genetic and microhabitat variation within populations can generate diverse responses to common environmental fluctuations, dampening temporal variability across the population as a whole through portfolio effects. Yet, the potential for portfolio effects to operate at small scales within populations or to change with systematic environmental shifts, such as climate change, remain largely unexplored...
January 23, 2017: Ecology
https://www.readbyqxmd.com/read/28011747/nanogenotoxicology-present-and-the-future
#6
Shareen H Doak, Maria Dusinska
This Mutagenesis special issue is on the topic of nanogenotoxicology. It unites a collection of reports that provide insight into: (i) the properties of engineered nanomaterials (ENMs) that contribute to genotoxicity, (ii) the genotoxic mechanisms associated with DNA damage observed in both in vitro and in vivo tests and (iii) the future test systems that will provide more accurate prediction of ENM genotoxicity to support regulatory hazard assessment frameworks. The contributions within therefore provide collective oversight of our current understanding, coupled to future perspectives aimed at overcoming technical hurdles and describing novel analytical methods to further advance the field...
January 2017: Mutagenesis
https://www.readbyqxmd.com/read/27942789/evaluation-of-the-automated-microflow-%C3%A2-and-metafer%C3%A2-platforms-for-high-throughput-micronucleus-scoring-and-dose-response-analysis-in-human-lymphoblastoid-tk6-cells
#7
Jatin R Verma, Benjamin J Rees, Eleanor C Wilde, Catherine A Thornton, Gareth J S Jenkins, Shareen H Doak, George E Johnson
The use of manual microscopy for the scoring of chromosome damage in the in vitro micronucleus assay is often associated with user subjectivity. This level of subjectivity can be reduced by using automated platforms, which have added value of faster with high-throughput and multi-endpoint capabilities. However, there is a need to assess the reproducibility and sensitivity of these automated platforms compared with the gold standard of the manual scoring. The automated flow cytometry-based MicroFlow(®) and image analysis-based Metafer™ were used for dose response analyses in human lymphoblastoid TK6 cells exposed to the model clastogen, methyl methanesulfonate (MMS), aneugen, carbendazim, and the weak genotoxic carcinogen, ochratoxin A (OTA)...
December 10, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27927018/microbiome-growth-retardation-and-metabolism-are-they-related
#8
Daniel J Hoffman, Maiza Campos-Ponce, Carla R Taddei, Colleen M Doak
CONTEXT: Despite an improvement in food security and the delivery of nutritional supplements to children living in impoverished parts of the world, poor growth is still highly prevalent. Given that the microbiome is related to both nutrient absorption, as well as overweight/obesity, it may play a central role in limiting or modifying normal growth processes while contributing to chronic disease risks. OBJECTIVE: The objective of this paper is to describe normal growth processes, the role of the microbiome in supporting or disrupting normal growth processes, and its potential impact on long-term health...
January 5, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/27883294/drug-discovery-beyond-the-rule-of-5-opportunities-and-challenges
#9
Bradley C Doak, Jan Kihlberg
No abstract text is available yet for this article.
December 8, 2016: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/27815329/critical-review-of-the-current-and-future-challenges-associated-with-advanced-in-vitro-systems-towards-the-study-of-nanoparticle-secondary-genotoxicity
#10
REVIEW
Stephen J Evans, Martin J D Clift, Neenu Singh, Jefferson de Oliveira Mallia, Michael Burgum, John W Wills, Thomas S Wilkinson, Gareth J S Jenkins, Shareen H Doak
With the need to understand the potential biological impact of the plethora of nanoparticles (NPs) being manufactured for a wide range of potential human applications, due to their inevitable human exposure, research activities in the field of NP toxicology has grown exponentially over the last decade. Whilst such increased research efforts have elucidated an increasingly significant knowledge base pertaining to the potential human health hazard posed by NPs, understanding regarding the possibility for NPs to elicit genotoxicity is limited...
January 2017: Mutagenesis
https://www.readbyqxmd.com/read/27778134/determination-of-ligand-binding-modes-in-weak-protein-ligand-complexes-using-sparse-nmr-data
#11
Biswaranjan Mohanty, Martin L Williams, Bradley C Doak, Mansha Vazirani, Olga Ilyichova, Geqing Wang, Wolfgang Bermel, Jamie S Simpson, David K Chalmers, Glenn F King, Mehdi Mobli, Martin J Scanlon
We describe a general approach to determine the binding pose of small molecules in weakly bound protein-ligand complexes by deriving distance constraints between the ligand and methyl groups from all methyl-containing residues of the protein. We demonstrate that using a single sample, which can be prepared without the use of expensive precursors, it is possible to generate high-resolution data rapidly and obtain the resonance assignments of Ile, Leu, Val, Ala and Thr methyl groups using triple resonance scalar correlation data...
October 24, 2016: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/27765679/coating-of-quantum-dots-strongly-defines-their-effect-on-lysosomal-health-and-autophagy
#12
Karen Peynshaert, Stefaan J Soenen, Bella B Manshian, Shareen H Doak, Kevin Braeckmans, Stefaan C De Smedt, Katrien Remaut
In the last decade the interest in autophagy got an incredible boost and the phenomenon quickly turned into an extensive research field. Interestingly, dysfunction of this cytoplasmic clearance system has been proposed to lie at the root of multiple diseases including cancer. We therefore consider it crucial from a toxicological point of view to investigate if nanomaterials that are developed for biomedical applications interfere with this cellular process. Here, we study the highly promising 'gradient alloyed' Quantum Dots (QDs) that differ from conventional ones by their gradient core composition which allows for better fluorescent properties...
October 17, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27752749/variability-in-practice-patterns-in-stress-urinary-incontinence-and-pelvic-organ-prolapse-results-of-an-iuga-survey
#13
Dorothy Kammerer-Doak, Kamil Svabik, Tony Bazi
INTRODUCTION AND HYPOTHESIS: Members of the International Urogynecological Association (IUGA) come from different geographic locations and practice settings. A member survey regarding practice patterns provides valuable information for practitioners and researchers alike, and allows the IUGA to discover areas to focus on education and information dissemination. METHODS: A questionnaire was developed by the IUGA Research and Development committee and distributed electronically to IUGA surgeons...
October 17, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27748751/structural-and-conformational-determinants-of-macrocycle-cell-permeability
#14
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall, Jan Kihlberg
Macrocycles are of increasing interest as chemical probes and drugs for intractable targets like protein-protein interactions, but the determinants of their cell permeability and oral absorption are poorly understood. To enable rational design of cell-permeable macrocycles, we generated an extensive data set under consistent experimental conditions for more than 200 non-peptidic, de novo-designed macrocycles from the Broad Institute's diversity-oriented screening collection. This revealed how specific functional groups, substituents and molecular properties impact cell permeability...
October 17, 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27748567/is-nickel-chloride-really-a-non-genotoxic-carcinogen
#15
REVIEW
Leanne Stannard, Shareen H Doak, Ann Doherty, Gareth J Jenkins
Human beings are exposed to carcinogens through air, water, food and tobacco smoke. Nickel chloride (NiCl2 ) is a toxic and carcinogenic environmental and occupational pollutant, which was previously classified as a non-genotoxic carcinogen and thought to not directly alter the DNA. Non-genotoxic carcinogens such as NiCl2 are difficult to detect in vitro; hence, a heavy reliance on animal studies exists. NiCl2 has previously been classified as a non-genotoxic carcinogen (NGTC); however, after studying the effect of NiCl2 on many mechanistic end-points, it has become clear that NiCl2 behaves more like a genotoxic carcinogen...
October 17, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27742680/disentangling-the-taxonomy-of-rickettsiales-and-description-of-two-novel-symbionts-candidatus-bealeia-paramacronuclearis-and-candidatus-fokinia-cryptica-sharing-the-cytoplasm-of-the-ciliate-protist-paramecium-biaurelia
#16
Franziska Szokoli, Michele Castelli, Elena Sabaneyeva, Martina Schrallhammer, Sascha Krenek, Thomas G Doak, Thomas U Berendonk, Giulio Petroni
In the past 10 years, the number of endosymbionts described within the bacterial order Rickettsiales has constantly grown. Since 2006, 18 novel Rickettsiales genera inhabiting protists, such as ciliates and amoebae, have been described. In this work, we characterize two novel bacterial endosymbionts from Paramecium collected near Bloomington, IN. Both endosymbiotic species inhabit the cytoplasm of the same host. The Gram-negative bacterium "Candidatus Bealeia paramacronuclearis" occurs in clumps and is frequently associated with the host macronucleus...
December 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27722472/membrane-mechanical-properties-of-synthetic-asymmetric-phospholipid-vesicles
#17
Li Lu, William J Doak, Jeffrey W Schertzer, Paul R Chiarot
Synthetic lipid vesicles have served as important model systems to study cellular membrane biology. Research has shown that the mechanical properties of bilayer membranes significantly affects their biological behavior. The properties of a lipid bilayer are governed by lipid acyl chain length, headgroup type, and the presence of membrane proteins. However, few studies have explored how membrane architecture, in particular trans-bilayer lipid asymmetry, influences membrane mechanical properties. In this study, we investigated the effects of lipid bilayer architecture (i...
September 13, 2016: Soft Matter
https://www.readbyqxmd.com/read/27637481/a-comparison-of-the-genotoxicity-of-benzo-a-pyrene-in-four-cell-lines-with-differing-metabolic-capacity
#18
COMPARATIVE STUDY
Ume-Kulsoom Shah, Anna L Seager, Paul Fowler, Shareen H Doak, George E Johnson, Sharon J Scott, Andrew D Scott, Gareth J S Jenkins
Benzo[a]pyrene (B[a]P) is a known genotoxin and carcinogen, yet its genotoxic response at low level exposure has not been determined. This study was conducted to examine the interplay of dose and metabolic capacity on genotoxicity of B[a]P. Investigating and better understanding the biological significance of low level chemical exposures will help improve human health risk assessments. The genotoxic and mutagenic effects of B[a]P were investigated using human cell lines (AHH-1, MCL-5, TK6 and HepG2) with differential expression of the CYP450 enzymes CYP1A1, 1B1 and1A2 involved in B[a]P metabolism...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27613375/genetic-toxicity-assessment-of-engineered-nanoparticles-using-a-3d-in-vitro-skin-model-epiderm%C3%A2
#19
John W Wills, Nicole Hondow, Adam D Thomas, Katherine E Chapman, David Fish, Thierry G Maffeis, Mark W Penny, Richard A Brown, Gareth J S Jenkins, Andy P Brown, Paul A White, Shareen H Doak
BACKGROUND: The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays desirable for nanosafety screening. However, conflicting outcomes are often observed when in vitro and in vivo study results are compared, suggesting more physiologically representative in vitro models are required to minimise reliance on animal testing. METHOD: BASF Levasil® silica nanoparticles (16 and 85 nm) were used to adapt the 3D reconstructed skin micronucleus (RSMN) assay for nanomaterials administered topically or into the growth medium...
September 9, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27567283/factors-affecting-the-in-vitro-micronucleus-assay-for-evaluation-of-nanomaterials
#20
Yan Li, Shareen H Doak, Jian Yan, David H Chen, Min Zhou, Roberta A Mittelstaedt, Ying Chen, Chun Li, Tao Chen
A number of in vitro methodologies have been used to assess the genotoxicity of different nanomaterials, including titanium dioxide nanoparticles (TiO2 NPs) and silver nanoparticles (AgNPs). The in vitro micronucleus assay is one of the most commonly used test methods for genotoxicity evaluation of nanomaterials. However, due to the novel features of nanomaterials, such as high adsorption capacity and fluorescence properties, there are unexpected interactions with experimental components and detection systems...
January 2017: Mutagenesis
keyword
keyword
26598
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"