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https://www.readbyqxmd.com/read/29364525/intestinal-parasites-associations-with-intestinal-and-systemic-inflammation
#1
Gerardo A Zavala, Olga P García, Mariela Camacho, Dolores Ronquillo, Maiza Campos-Ponce, Colleen Doak, Katja Polman, Jorge L Rosado
AIMS: Evaluate associations between intestinal parasitic infection with intestinal and systemic inflammatory markers in school-aged children with high rates of obesity. METHODS AND RESULTS: Plasma concentrations of CRP, leptin, TNF-α, IL-6 and IL-10 were measured as systemic inflammation markers and count of stool leukocytes as marker of intestinal inflammation in 291 children (6-10y). Intestinal parasitic infection was measured by stool examination. Logistic regression analyses were performed to determine the odds of having high inflammatory markers for each parasite or group of parasites as compared to parasite-free children while adjusting for sex, age, mother educational level and % of body fat...
January 24, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29307375/a-three-dimensional-in-vitro-hepg2-cells-liver-spheroid-model-for-genotoxicity-studies
#2
Ume-Kulsoom Shah, Jefferson de Oliveira Mallia, Neenu Singh, Katherine E Chapman, Shareen H Doak, Gareth J S Jenkins
The liver's role in metabolism of chemicals makes it an appropriate tissue for toxicity testing. Current testing protocols, such as animal testing and two-dimensional liver cell systems, offer limited resemblance to in vivo liver cell behaviour, in terms of gene expression profiles and metabolic competence; thus, they do not always accurately predict human toxicology. In vitro three-dimensional liver cell models offer an attractive alternative. This study reports on the development of a 3D liver model, using HepG2 cells, by a hanging-drop technique, with a focus on evaluating spheroid growth characteristics and suitability for genotoxicity testing...
January 2018: Mutation Research
https://www.readbyqxmd.com/read/29306639/skin-tissue-engineering-using-3d-bioprinting-an-evolving-research-field
#3
REVIEW
Sam P Tarassoli, Zita M Jessop, Ayesha Al-Sabah, Neng Gao, Sairan Whitaker, Shareen Doak, Iain S Whitaker
BACKGROUND: Commercially available tissue engineered skin remains elusive despite extensive research because the multi-stratified anisotropic structure is difficult to replicate in vitro using traditional tissue engineering techniques. Bioprinting, involving computer-controlled deposition of cells and scaffolds into spatially controlled patterns, is able to control not only the macro but also micro and nanoarchitecture and could offer the potential to more faithfully replicate native skin...
December 13, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29284748/aridity-weakens-population-level-effects-of-multiple-species-interactions-on-hibiscus-meyeri
#4
Allison M Louthan, Robert M Pringle, Jacob R Goheen, Todd M Palmer, William F Morris, Daniel F Doak
Predicting how species' abundances and ranges will shift in response to climate change requires a mechanistic understanding of how multiple factors interact to limit population growth. Both abiotic stress and species interactions can limit populations and potentially set range boundaries, but we have a poor understanding of when and where each is most critical. A commonly cited hypothesis, first proposed by Darwin, posits that abiotic factors (e.g., temperature, precipitation) are stronger determinants of range boundaries in apparently abiotically stressful areas ("stress" indicates abiotic factors that reduce population growth), including desert, polar, or high-elevation environments, whereas species interactions (e...
December 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29231920/two-colour-serial-femtosecond-crystallography-dataset-from-gadoteridol-derivatized-lysozyme-for-mad-phasing
#5
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R Bruce Doak, Marie Luise Grünbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Nass Kovács, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Lutz Foucar, Yasumasa Joti, Makina Yabashi, So Iwata, Kiyoshi Ueda, Thomas R M Barends, Ilme Schlichting
We provide a detailed description of a gadoteridol-derivatized lysozyme (gadolinium lysozyme) two-colour serial femtosecond crystallography (SFX) dataset for multiple wavelength anomalous dispersion (MAD) structure determination. The data was collected at the Spring-8 Angstrom Compact free-electron LAser (SACLA) facility using a two-colour double-pulse beam to record two diffraction patterns simultaneously in one diffraction image. Gadolinium lysozyme was chosen as a well-established model system that has a very strong anomalous signal...
December 12, 2017: Scientific Data
https://www.readbyqxmd.com/read/29222574/improving-hearing-aid-self-efficacy-and-utility-through-revising-a-hearing-aid-user-guide-a-pilot-study
#6
Alexandra McMullan, Rebecca J Kelly-Campbell, Kim Wise
Purpose: This pilot study aimed to investigate whether revising a hearing aid user guide (HAUG) is associated with improved hearing aid self-efficacy and utility performance. Method: In Part 1, an HAUG was evaluated using the Suitability Assessment of Material (SAM) and readability formulas (Flesch Reading Ease [Flesch, 1943], Flesch-Kincaid Readability Formula [Kincaid, Fishburne, Rogers, & Chissom, 1957], and Simple Measure of Gobbledygook [McLaughlin, 1969])...
December 8, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29155464/both-life-history-plasticity-and-local-adaptation-will-shape-range-wide-responses-to-climate-warming-in-the-tundra-plant-silene-acaulis
#7
Megan L Peterson, Daniel F Doak, William F Morris
Many predictions of how climate change will impact biodiversity have focused on range shifts using species-wide climate tolerances, an approach that ignores the demographic mechanisms that enable species to attain broad geographic distributions. But these mechanisms matter, as responses to climate change could fundamentally differ depending on the contributions of life history plasticity vs local adaptation to species-wide climate tolerances. In particular, if local adaptation to climate is strong, populations across a species' range - not only those at the trailing range edge - could decline sharply with global climate change...
November 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29110037/a-novel-integrated-in-vitro-carcinogenicity-test-to-identify-genotoxic-and-non-genotoxic-carcinogens-using-human-lymphoblastoid-cells
#8
Eleanor C Wilde, Katherine E Chapman, Leanne M Stannard, Anna L Seager, Katja Brüsehafer, Ume-Kulsoom Shah, James A Tonkin, M Rowan Brown, Jatin R Verma, Ann T Doherty, George E Johnson, Shareen H Doak, Gareth J S Jenkins
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70-90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation. Both current in vitro genotoxicity tests and the animal-testing paradigm in human cancer risk assessment fail to accurately represent and predict whether a chemical causes human carcinogenesis. The study aimed to establish whether the integrated analysis of multiple cellular endpoints related to the Hallmarks of Cancer could advance in vitro carcinogenicity assessment...
November 6, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29079797/multi-wavelength-anomalous-diffraction-de-novo-phasing-using-a-two-colour-x-ray-free-electron-laser-with-wide-tunability
#9
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R Bruce Doak, Marie Luise Grünbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Kovácsová, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, So Iwata, Lutz Foucar, Kiyoshi Ueda, Thomas R M Barends, Ilme Schlichting
Serial femtosecond crystallography at X-ray free-electron lasers (XFELs) offers unprecedented possibilities for macromolecular structure determination of systems prone to radiation damage. However, de novo structure determination, i.e., without prior structural knowledge, is complicated by the inherent inaccuracy of serial femtosecond crystallography data. By its very nature, serial femtosecond crystallography data collection entails shot-to-shot fluctuations in X-ray wavelength and intensity as well as variations in crystal size and quality that must be averaged out...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29078245/-antiembolic-stockings-great-effects-in-edoxaban-approval-studies
#10
Knut Kroeger, Peter Kujath
In this age of evidence-based medicine, the use of medical thrombosis prophylaxis stockings (AES) as a physical strategy for the prevention of lower limb venous thrombosis has been questioned. The current German S3 guidelines even state that their non-application is, in the vast majority of cases, explicitly covered by the recommendations of this guideline. Low molecular weight heparins (NMH) and direct oral anticoagulants (DOAK) have received approval for thrombosis prophylaxis in elective knee and hip joint replacement, but the use of AES is absent from these approval studies...
October 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29072897/characterizing-nanoparticles-in-biological-matrices-tipping-points-in-agglomeration-state-and-cellular-delivery-in-vitro
#11
John W Wills, Huw D Summers, Nicole Hondow, Aishwarya Sooresh, Kenith E Meissner, Paul A White, Paul Rees, Andy Brown, Shareen H Doak
Understanding the delivered cellular dose of nanoparticles is imperative in nanomedicine and nanosafety, yet is known to be extremely complex because of multiple interactions between nanoparticles, their environment, and the cells. Here, we use 3-D reconstruction of agglomerates preserved by cryogenic snapshot sampling and imaged by electron microscopy to quantify the "bioavailable dose" that is presented at the cell surface and formed by the process of individual nanoparticle sequestration into agglomerates in the exposure media...
November 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/29069581/aligning-nanotoxicology-with-the-3rs-what-is-needed-to-realise-the-short-medium-and-long-term-opportunities
#12
Natalie Burden, Karin Aschberger, Qasim Chaudhry, Martin J D Clift, Paul Fowler, Helinor Johnston, Robert Landsiedel, Joanna Rowland, Vicki Stone, Shareen H Doak
Nanomaterials convey numerous advantages, and the past decade has seen a considerable rise in their development and production for an expanse of applications. While the potential advantages of nanomaterials are clear, concerns over the impact of human and environmental exposure exist. Concerted, science-led efforts are required to understand the effects of nanomaterial exposure and ensure that protection goals are met. There is much on-going discussion regarding how best to assess nanomaterial risk, particularly considering the large number of tests that may be required...
October 22, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29064473/corrigendum-diffraction-data-of-core-shell-nanoparticles-from-an-x-ray-free-electron-laser
#13
Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H Huang, John C H Spence, Ilme Schlichting, Brenda G Hogue, Haiguang Liu
This corrects the article DOI: 10.1038/sdata.2017.48.
October 24, 2017: Scientific Data
https://www.readbyqxmd.com/read/28960343/prediction-of-seebeck-coefficient-for-compounds-without-restriction-to-fixed-stoichiometry-a-machine-learning-approach
#14
Al'ona Furmanchuk, James E Saal, Jeff W Doak, Gregory B Olson, Alok Choudhary, Ankit Agrawal
The regression model-based tool is developed for predicting the Seebeck coefficient of crystalline materials in the temperature range from 300 K to 1000 K. The tool accounts for the single crystal versus polycrystalline nature of the compound, the production method, and properties of the constituent elements in the chemical formula. We introduce new descriptive features of crystalline materials relevant for the prediction the Seebeck coefficient. To address off-stoichiometry in materials, the predictive tool is trained on a mix of stoichiometric and nonstoichiometric materials...
September 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28875027/viscous-hydrophilic-injection-matrices-for-serial-crystallography
#15
Gabriela Kovácsová, Marie Luise Grünbein, Marco Kloos, Thomas R M Barends, Ramona Schlesinger, Joachim Heberle, Wolfgang Kabsch, Robert L Shoeman, R Bruce Doak, Ilme Schlichting
Serial (femtosecond) crystallography at synchrotron and X-ray free-electron laser (XFEL) sources distributes the absorbed radiation dose over all crystals used for data collection and therefore allows measurement of radiation damage prone systems, including the use of microcrystals for room-temperature measurements. Serial crystallography relies on fast and efficient exchange of crystals upon X-ray exposure, which can be achieved using a variety of methods, including various injection techniques. The latter vary significantly in their flow rates - gas dynamic virtual nozzle based injectors provide very thin fast-flowing jets, whereas high-viscosity extrusion injectors produce much thicker streams with flow rates two to three orders of magnitude lower...
July 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28853740/erratum-structural-and-conformational-determinants-of-macrocycle-cell-permeability
#16
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall, Jan Kihlberg
No abstract text is available yet for this article.
July 18, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28743469/energy-and-food-intake-are-associated-with-specific-intestinal-parasitic-infections-in-children-of-rural-mexico
#17
Gerardo A Zavala, Jorge L Rosado, Colleen M Doak, Maria Del Carmen Caamaño, Maiza Campos-Ponce, Dolores Ronquillo, Katja Polman, Olga P García
No abstract text is available yet for this article.
December 2017: Parasitology International
https://www.readbyqxmd.com/read/28703770/exposure-to-engineered-nanomaterials-impact-on-dna-repair-pathways
#18
REVIEW
Neenu Singh, Bryant C Nelson, Leona D Scanlan, Erdem Coskun, Pawel Jaruga, Shareen H Doak
Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA damage repair pathways involved in the processing of DNA damage. However, the vast array of ENMs may present a relatively new challenge to the integrity of the human genome; therefore, the potential hazard posed by some ENMs necessitates the evaluation and understanding of ENM-induced DNA damage repair pathways...
July 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28659454/correction-to-wind-and-rain-are-the-primary-climate-factors-driving-changing-phenology-of-an-aerial-insectivore
#19
Rachel D Irons, April Harding Scurr, Alexandra P Rose, Julie C Hagelin, Tricia Blake, Daniel F Doak
No abstract text is available yet for this article.
June 28, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28622829/investigation-of-j-shaped-dose-responses-induced-by-exposure-to-the-alkylating-agent-n-methyl-n-nitrosourea
#20
Katherine E Chapman, George R Hoffmann, Shareen H Doak, Gareth J S Jenkins
Hormesis is defined as a biphasic dose-response where biological effects of low doses of a stressor demonstrate the opposite effect to high-dose effects of the same stressor. Hormetic, or J-shaped, dose-response relationships are relatively rarely observed in toxicology, resulting in a limited understanding and even some skepticism of the concept. Low dose-response studies for genotoxicity endpoints have been performed at Swansea University for over a decade. However, no statistically significant decreases below control genotoxicity levels have been detected until recently...
July 2017: Mutation Research
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