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https://www.readbyqxmd.com/read/29346597/exenatide-increases-il-1ra-concentration-and-induces-nrf-2-keap-1-regulated-anti-oxidant-enzymes-relevance-to-%C3%AE-cell-function
#1
Paresh Dandona, Husam Ghanim, Sanaa Abuaysheh, Kelly Green, Sandeep Dhindsa, Antoine Makdissi, Manav Batra, Nitesh D Kuhadiya, Ajay Chaudhuri
Purpose: We have previously demonstrated anti-inflammatory and antioxidant effects of exenatide. We have now hypothesized that exenatide also increases the plasma concentration of IL-1RA, an endogenous anti-inflammatory protein and modulates the Nrf-2-Keap-1-ARE system to induce key antioxidant enzymes to suppress inflammatory and oxidative stress. Methods: Twenty four obese type 2 diabetic patients on combined oral and insulin therapy were randomized to receive either exenatide 10μg or placebo b...
January 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29339527/diminished-androgen-and-estrogen-receptors-and-aromatase-levels-in-hypogonadal-diabetic-men-reversal-with-testosterone
#2
Husam Ghanim, Sandeep Dhindsa, Sanaa Abuaysheh, Manav Batra, Nitesh Kuhadiya, Antoine Makdissi, Ajay Chaudhuri, Paresh Dandona
AIMS: One third of males with type 2 diabetes have hypogonadism, characterized by low total and free testosterone concentrations. We hypothesized that this condition is associated with a compensatory increase in the expression of androgen receptors (AR) and that testosterone replacement reverses these changes. We also measured estrogen receptor and aromatase expression. MATERIALS AND METHODS: This is a randomized double-blind placebo controlled trial. 32 hypogonadal and 32 eugonadal men with type 2 diabetes were recruited...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29337790/can-a-multicenter-pneumonia-zero-bundle-reduce-ventilator-associated-pneumonias
#3
Ramzy Husam Rimawi, David J Murphy
No abstract text is available yet for this article.
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29334500/overexpression-of-%C3%A2%C2%B5-opioid-receptors-in-peripheral-afferents-but-not-in-combination-with-enkephalin-decreases-neuropathic-pain-behavior-and-enhances-opioid-analgesia-in-mouse
#4
Amanda H Klein, Husam K Mohammad, Rabiah Ali, Brad Peper, Steven P Wilson, Srinivasa N Raja, Matthias Ringkamp, Sarah Sweitzer
BACKGROUND: The current study used recombinant herpes simplex virus type I to increase expression of µ-opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. It was predicted that viral vector delivery of a combination of genes encoding the µ-opioid receptor and preproenkephalin would attenuate neuropathic pain and enhance opioid analgesia. The behavioral effects would be paralleled by changes in response properties of primary afferent neurons...
January 15, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29318670/a-self-powered-and-flexible-organometallic-halide-perovskite-photodetector-with-very-high-detectivity
#5
Siu-Fung Leung, Kang-Ting Ho, Po-Kai Kung, Vincent K S Hsiao, Husam N Alshareef, Zhong Lin Wang, Jr-Hau He
Flexible and self-powered photodetectors (PDs) are highly desirable for applications in image sensing, smart building, and optical communications. In this paper, a self-powered and flexible PD based on the methylammonium lead iodide (CH3 NH3 PBI3 ) perovskite is demonstrated. Such a self-powered PD can operate even with irregular motion such as human finger tapping, which enables it to work without a bulky external power source. In addition, with high-quality CH3 NH3 PBI3 perovskite thin film fabricated with solvent engineering, the PD exhibits an impressive detectivity of 1...
January 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29247550/melatonin-prevents-hypochlorous-acid-mediated-cyanocobalamin-destruction-and-cyanogen-chloride-generation
#6
Roohi Jeelani, Dhiman Maitra, Charalampos Chatzicharalampous, Syed Najeemuddin, Robert T Morris, Husam M Abu-Soud
Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we have highlighted the ability of HOCl to mediate the destruction of the metal-ion derivatives of tetrapyrrole macrocyclic rings such as hemoproteins and vitamin B12 (VB12 ) derivatives. Destruction of cyanocobalamin, a common pharmacological form of VB12 mediated by HOCl, results in the generation of toxic molecular products such as chlorinated derivatives, corrin ring cleavage products, the toxic blood agents cyanide (CN- ) and cyanogen chloride (CNCl), and redox-active free cobalt...
December 16, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29247186/evidence-for-topological-type-ii-weyl-semimetal-wte2
#7
Peng Li, Yan Wen, Xin He, Qiang Zhang, Chuan Xia, Zhi-Ming Yu, Shengyuan A Yang, Zhiyong Zhu, Husam N Alshareef, Xi-Xiang Zhang
Recently, a type-II Weyl fermion was theoretically predicted to appear at the contact of electron and hole Fermi surface pockets. A distinguishing feature of the surfaces of type-II Weyl semimetals is the existence of topological surface states, so-called Fermi arcs. Although WTe2 was the first material suggested as a type-II Weyl semimetal, the direct observation of its tilting Weyl cone and Fermi arc has not yet been successful. Here, we show strong evidence that WTe2 is a type-II Weyl semimetal by observing two unique transport properties simultaneously in one WTe2 nanoribbon...
December 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233826/association-of-atrial-fibrillation-and-oral-anticoagulant-use-with-perioperative-outcomes-after-major-noncardiac-surgery
#8
Yin Ge, Andrew C T Ha, Clare L Atzema, Husam M Abdel-Qadir, Jiming Fang, Peter C Austin, Duminda N Wijeysundera, Douglas S Lee
BACKGROUND: We examined the association of atrial fibrillation (AF) and oral anticoagulant use with perioperative death and bleeding among patients undergoing major noncardiac surgery. METHODS AND RESULTS: A population-based study of patients aged 66 years and older who underwent elective (n=87 257) or urgent (n=35 930) noncardiac surgery in Ontario, Canada (April 2012 to March 2015) was performed. Outcomes were compared between AF groups using inverse probability of treatment weighting using the propensity score...
December 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29232296/morbid-obesity-does-not-increase-morbidity-or-mortality-in-robotic-cardiac-surgery
#9
Hiroto Kitahara, Brooke Patel, Mackenzie McCrorey, Sarah Nisivaco, Husam H Balkhy
OBJECTIVE: Morbid obesity (body mass index ≥ 35 kg/m) usually confers a higher perioperative risk in cardiac surgery. Robotic cardiac surgery may have many advantages for these high-risk patients. METHODS: We retrospectively reviewed patients undergoing robotic cardiac surgery from July 2013 to April 2017 at our institution. We compared the outcomes of morbidly obese patients versus nonobese patients. RESULTS: A total of 486 patients underwent robotic cardiac surgery (322 men, median age = 65 years)...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29226488/rechargeable-aqueous-zinc-ion-battery-based-on-porous-framework-zinc-pyrovanadate-intercalation-cathode
#10
Chuan Xia, Jing Guo, Yongjiu Lei, Hanfeng Liang, Chao Zhao, Husam N Alshareef
In this work, a microwave approach is developed to rapidly synthesize ultralong zinc pyrovanadate (Zn3 V2 O7 (OH)2 ·2H2 O, ZVO) nanowires with a porous crystal framework. It is shown that our synthesis strategy can easily be extended to fabricate other metal pyrovanadate compounds. The zinc pyrovanadate nanowires show significantly improved electrochemical performance when used as intercalation cathode for aqueous zinc-ion battery. Specifically, the ZVO cathode delivers high capacities of 213 and 76 mA h g-1 at current densities of 50 and 3000 mA g-1 , respectively...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29200943/cancer-related-post-treatment-pain-and-its-impact-on-health-related-quality-of-life-in-breast-cancer-patients-a-cross-sectional-study-in-palestine
#11
Nader H Abu Farha, Mohammed T Khatib, Husam Salameh, Sa'ed H Zyoud
Background: Post-treatment pain has been suggested as an important indicator for health-related quality of life (HRQOL) in patients with breast cancer. Therefore, this study was performed to examine the association between pain and its impact on HRQOL among breast cancer patients in Palestine. Also, this study aimed to determine the QOL profile for breast cancer patients and stated the factors associated with QOL. Methods: A correlational cross-sectional study was conducted from May 2016 to November 2016 at Al-Watani Hospital and An-Najah National University Hospital in the Nablus district in Palestine...
2017: Asia Pacific Family Medicine
https://www.readbyqxmd.com/read/29193376/evaluation-of-left-ventricular-reverse-remodeling-in-patients-with-severe-aortic-regurgitation-undergoing-aortic-valve-replacement-comparison-between-diameters-and-volumes
#12
Géraldine Ong, Bjorn Redfors, Aaron Crowley, Husam Abdel-Qadir, Alana Harrington, Yangbo Liu, Myriam Lafrenière-Roula, Howard Leong-Poi, Mark D Peterson, Kim A Connelly
BACKGROUND: In patients with severe aortic regurgitation (AR), the left ventricular ejection fraction (LVEF) and left ventricle (LV) size are crucial for determining clinical prognosis and timing of valve intervention. In clinical practice, LV internal diameters obtained at end-diastole are used to assess the degree of LV dilatation. Whether quantification of LV volumes would provide more robust information as compared to LV linear dimensions is unknown. METHODS: We retrospectively analyzed preoperative and postoperative transthoracic echocardiograms of patients who underwent aortic valve replacement (AVR) for severe AR...
November 28, 2017: Echocardiography
https://www.readbyqxmd.com/read/29192276/protein-lysine-methyltransferases-g9a-and-glp1-promote-responses-to-dna-damage
#13
Vasudeva Ginjala, Lizahira Rodriguez-Colon, Bratati Ganguly, Prawallika Gangidi, Paul Gallina, Husam Al-Hraishawi, Atul Kulkarni, Jeremy Tang, Jinesh Gheeya, Srilatha Simhadri, Ming Yao, Bing Xia, Shridar Ganesan
Upon induction of DNA breaks, ATM activation leads to a cascade of local chromatin modifications that promote efficient recruitment of DNA repair proteins. Errors in this DNA repair pathway lead to genomic instability and cancer predisposition. Here, we show that the protein lysine methyltransferase G9a (also known as EHMT2) and GLP1 (also known as EHMT1) are critical components of the DNA repair pathway. G9a and GLP1 rapidly localizes to DNA breaks, with GLP1 localization being dependent on G9a. ATM phosphorylation of G9a on serine 569 is required for its recruitment to DNA breaks...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29179235/atypical-neurologic-phenotype-and-novel-slc30a10-mutation-in-two-brothers-with-hereditary-hypermanganesemia
#14
Shamshad Gulab, Husam R Kayyali, Youssef Al-Said
No abstract text is available yet for this article.
November 27, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/29170295/bet-1-can-the-manchester-acute-coronary-syndromes-and-troponin-only-manchester-acute-coronary-syndromes-decision-aids-rule-out-acute-coronary-syndromes-in-the-emergency-department
#15
Charles Reynard, Husam Ismail, Nicholas Hadden
A short-cut review was carried out to establish whether the Manchester Acute Coronary Syndromes (MACS) and Troponin-only MACS (T-MACS) decision aids can safely rule out acute coronary syndromes in patients presenting to the ED with suspected cardiac chest pain. Six studies were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. The clinical bottom line is that both rules have high sensitivity for acute coronary syndromes, including the detection of major adverse cardiac events at 30 days...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29153808/redo-robotic-endoscopic-beating-heart-coronary-bypass-tecab-after-previous-tecab
#16
Sarah Nisivaco, Mackenzie McCrorey, Dorothy Krienbring, Brooke Patel, Sudhir Srivastava, Husam H Balkhy
Redo-totally endoscopic coronary artery bypass (TECAB) after previous TECAB to our knowledge has never been reported in the literature. We present a case report of a 65-year-old gentleman who underwent a second beating-heart TECAB with the right internal mammary artery (IMA) to the obtuse marginal branch, following previous TECAB (left IMA-diagonal/left anterior descending). An extensive experience in robotic coronary operation and anastomotic devices contributed to the successful outcome in this patient. We conclude that prior TECAB is not a contraindication to redo-TECAB as long as an IMA conduit is available and left lung adhesions are not prohibitive...
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29093925/dementia-and-family-burden-of-care-in-lebanon
#17
Monique Chaaya, Kieu Phung, Samir Atweh, Khalil El Asmar, Georges Karam, Rosemary Khoury, Lilian Ghandour, Husam Ghusn, Sarah Assaad, Martin Prince, Gunhild Waldemar
The burden on and mental well-being of family carers for the elderly, especially those with dementia, has been well studied in high-income countries and to a lesser extent in the Arab region. Our study of Lebanese carers highlights the importance of considering the psychological well-being of the family carer, and the role of dementia and depression in increasing the burden of care. Psychosocial interventions have produced equivocal results and therefore customised and contextualised interventions need to be researched...
February 2017: BJPsych International
https://www.readbyqxmd.com/read/29028651/endoscopic-conduit-harvest-in-coronary-artery-bypass-grafting-surgery-an-ismics-systematic-review-and-consensus-conference-statements
#18
Francis D Ferdinand, John K MacDonald, Husam H Balkhy, Gianluigi Bisleri, Ho Young Hwang, Patricia Northrup, Richard H J Trimlett, Lai Wei, Bob B Kiaii
OBJECTIVE: The purpose of this consensus conference was to develop and update evidence-informed consensus statements and recommendations on harvesting saphenous vein and radial artery via an open as compared with endoscopic technique by systematically reviewing and performing a meta-analysis of randomized and nonrandomized clinical trials. METHODS: All randomized controlled trials and nonrandomized controlled trials included in the first the International Society for Minimally Invasive Cardiothoracic Surgery Consensus Conference and Statements, in 2005 up to November 30, 2015, were included in a systematic review and meta-analysis...
September 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29024574/effects-of-plasma-jet-dielectric-barrier-discharge-photodynamic-therapy-and-sodium-hypochlorite-on-infected-curved-root-canals
#19
Husam Ballout, Moritz Hertel, Jonas Doehring, Eckehard Kostka, Stefan Hartwig, Sebastian Paris, Saskia Preissner
The aim of this investigation was to evaluate the effects of two different cold atmospheric plasma (CAP) sources, photodynamic therapy and sodium hypochlorite (NaOCl), on infected root canals. Therefore, 50 standardized curved human root canals were infected with Enterococcus faecalis and assigned to five groups - negative control (NC), plasma jet (CAP I), dielectric barrier discharge (CAP II), photodynamic therapy (PDT), and NaOCl + PUI - for 30 s. Colony forming units (CFUs) were determined. NaOCl was significantly more effective at reducing CFUs than all test groups (p < ...
October 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29023290/fascial-graft-repair-of-wide-bilateral-cleft-lip-deformity
#20
Husam Hosny, Ayman Husein Abdelsattar
Wide bilateral cleft lip deformity reconstruction represents a special difficulty as it affects the lip, nose, and maxillary segments making single-stage reconstruction sometimes unobtainable. Many surgical and nonsurgical techniques have been prescribed to facilitate the definitive repair. Although some of these techniques proved to be useful, they have their inherent limitations and add another treatment step with all its possible complications and costs. The authors present a new method to address muscle layer repair in 1-stage procedure...
October 11, 2017: Journal of Craniofacial Surgery
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