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https://www.readbyqxmd.com/read/29791284/risk-imaging-mismatch-in-cardiac-imaging-practices-for-women-receiving-systemic-therapy-for-early-stage-breast-cancer-a-population-based-cohort-study
#1
Paaladinesh Thavendiranathan, Husam Abdel-Qadir, Hadas D Fischer, Ying Liu, Ximena Camacho, Eitan Amir, Peter C Austin, Douglas S Lee
Purpose To assess prechemotherapy cardiac imaging practices in relation to patients' heart failure (HF) risk. Methods We performed a population-based retrospective cohort study of women receiving chemotherapy for early-stage breast cancer in Ontario between 2007 and 2012. We surveyed for baseline cardiac imaging 6 months before chemotherapy or within 30 days thereafter. The proportion of patients who underwent imaging and cumulative incidence of major adverse cardiac event (MACE) rates was determined based on chemotherapy regimen and HF risk factors...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29766688/assessing-effects-of-pressure-on-tumor-and-normal-tissue-physiology-using-an-automated-self-calibrated-pressure-sensing-probe-for-diffuse-reflectance-spectroscopy
#2
Gregory M Palmer, Hengtao Zhang, Chen-Ting Lee, Husam Mikati, Joseph A Herbert, Marlee Krieger, Jesko von Windheim, Dave Koester, Daniel Stevenson, Daniel J Rocke, Ramon Esclamado, Alaatin Erkanli, Nirmala Ramanujam, Mark W Dewhirst, Walter T Lee
Diffuse reflectance spectroscopy (DRS) represents a quantitative, noninvasive, nondestructive means of assessing vascular oxygenation, vascularity, and structural properties. However, it is known that such measurements can be influenced by the effects of pressure, which is a major concern for reproducible and operator-independent assessment of tissues. Second, regular calibration is a necessary component of quantitative DRS to account for factors such as lamp decay and fiber bending. Without a means of reliably controlling for these factors, the accuracy of any such assessments will be reduced, and potentially biased...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29765555/a-protein-folding-molecular-imaging-biosensor-monitors-the-effects-of-drugs-that-restore-mutant-p53-structure-and-its-downstream-function-in-glioblastoma-cells
#3
Ramasamy Paulmurugan, Rayhaneh Afjei, Thillai V Sekar, Husam A Babikir, Tarik F Massoud
Misfolding mutations in the DNA-binding domain of p53 alter its conformation, affecting the efficiency with which it binds to chromatin to regulate target gene expression and cell cycle checkpoint functions in many cancers, including glioblastoma. Small molecule drugs that recover misfolded p53 structure and function may improve chemotherapy by activating p53-mediated senescence. We constructed and optimized a split Renilla luciferase (RLUC) complementation molecular biosensor (NRLUC-p53-CRLUC) to determine small molecule-meditated folding changes in p53 protein...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765554/targeted-nanoparticle-delivery-of-therapeutic-antisense-micrornas-presensitizes-glioblastoma-cells-to-lower-effective-doses-of-temozolomide-in-vitro-and-in-a-mouse-model
#4
Meenakshi Malhotra, Thillai Veerapazham Sekar, Jeyarama S Ananta, Rammohan Devulapally, Rayhaneh Afjei, Husam A Babikir, Ramasamy Paulmurugan, Tarik F Massoud
Temozolomide (TMZ) chemotherapy for glioblastoma (GBM) is generally well tolerated at standard doses but it can cause side effects. GBMs overexpress microRNA-21 and microRNA-10b, two known oncomiRs that promote cancer development, progression and resistance to drug treatment. We hypothesized that systemic injection of antisense microRNAs (antagomiR-21 and antagomiR-10b) encapsulated in cRGD-tagged PEG-PLGA nanoparticles would result in high cellular delivery of intact functional antagomiRs, with consequent efficient therapeutic response and increased sensitivity of GBM cells to lower doses of TMZ...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29752820/elevated-anti-tissue-transglutaminase-antibodies-in-children-newly-diagnosed-with-type-1-diabetes-do-not-always-indicate-celiac-disease
#5
Firas Rinawi, Basel Badarneh, Osama Tanous, Husam Bashir, Yardena Tennenbaum-Rakover, Sarit Peleg
AIM: Elevated levels of anti-tissue transglutaminase (anti-tTG) antibody may spontaneously normalise in children with newly diagnosed type 1 diabetes, even if they eat gluten. The prevalence of this phenomenon, and predictors of a subsequent celiac disease (CD) diagnosis, were determined. METHODS: The medical records of children diagnosed with type 1 diabetes at Ha'Emek Medical Centre, Israel, from 2007-2015, were retrospectively reviewed for elevated anti-tTG antibody levels...
May 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29725763/tumor-cell-expression-of-cd163-is-associated-to-postoperative-radiotherapy-and-poor-prognosis-in-patients-with-breast-cancer-treated-with-breast-conserving-surgery
#6
Stina Garvin, Husam Oda, Lars-Gunnar Arnesson, Annelie Lindström, Ivan Shabo
PURPOSE: Cancer cell fusion with macrophages results in highly tumorigenic hybrids that acquire genetic and phenotypic characteristics from both maternal cells. Macrophage traits, exemplified by CD163 expression, in tumor cells are associated with advanced stages and poor prognosis in breast cancer (BC). In vitro data suggest that cancer cells expressing CD163 acquire radioresistance. METHODS: Tissue microarray was constructed from primary BC obtained from 83 patients treated with breast-conserving surgery, 50% having received postoperative radiotherapy (RT) and none of the patients had lymph node or distant metastasis...
May 3, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29724482/physician-visits-and-the-timing-of-skeletal-related-events-among-men-newly-diagnosed-with-metastatic-prostate-cancer-a-cohort-analysis
#7
Eberechukwu Onukwugha, Husam Albarmawi, Kai Sun, C Daniel Mullins, Abdalla Aly, Arif Hussain
INTRODUCTION: Men diagnosed with metastatic prostate cancer (PCa) are at increased risk for skeletal complications which are associated with significant morbidity and mortality. Although both the urologist and the medical oncologist play important roles in the management of patients with advanced PCa, there is limited information regarding their role in the context of skeletal complications. The current study investigated these relationships among newly diagnosed metastatic patients with PCa...
April 30, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29700926/robot-assisted-aortic-valve-surgery-state-of-the-art-and-challenges-for-the-future
#8
REVIEW
Husam H Balkhy, Clifton T P Lewis, Hiroto Kitahara
Robotic cardiac surgery was FDA-approved in 2002 and since then several different procedures have been performed to facilitate a truly minimally invasive approach. The use of robotics in aortic valve surgery, however, is still in its infancy. In this article, we report our clinical experience and chronological development with robot-assisted aortic valve surgery. This includes a description of how robotic assistance was gradually integrated during right mini-thoracotomy aortic valve replacement, a series of cases in which the robot was docked for parts of the procedure, a single case of a totally endoscopic robot-assisted aortic valve replacement with a stentless valve, and three cases of aortic valve papillary fibroelastoma resections...
April 27, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29688941/the-c-port-distal-coronary-anastomotic-device-is-comparable-with-a-hand-sewn-anastomosis-human-histological-case-study
#9
Husam H Balkhy, Sarah M Nisivaco, Aliya N Husain, Valluvan Jeevanandam, Quidsia Arif
Coronary artery bypass surgery is most commonly performed using a hand-sewn technique with a continuous monofilament suture. The C-Port distal anastomotic device is a miniature stapler designed to create an arteriotomy and attach the graft to the coronary artery all in one step. It is the only distal coronary anastomotic device currently approved for clinical use and can be useful in facilitating less invasive coronary surgery. This report examines the histological attributes of such an anastomosis in a patient who underwent heart transplantation approximately 1 year after robotic totally endoscopic stapled coronary bypass using the C-Port anastomotic device...
April 23, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29688940/robotic-beating-heart-totally-endoscopic-coronary-artery-bypass-in-higher-risk-patients-can-it-be-done-safely
#10
Husam H Balkhy, Sarah Nisivaco, Hiroto Kitahara, Mackenzie McCrorey, Brooke Patel
OBJECTIVE: Patients with a high Society of Thoracic Surgeons (STS) predicted risk of mortality undergoing coronary artery bypass surgery are known to have worse outcomes. Less invasive approaches have been shown to improve morbidity and mortality for these patients. In this study, we examined perioperative outcomes in higher-risk patients undergoing robotic totally endoscopic beating heart coronary artery bypass surgery. METHODS: The STS predicted risk of mortality was reviewed for patients undergoing robotic totally endoscopic beating heart coronary artery bypass surgery at our institution between January 2013 and May 2017...
March 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29687573/is-robotic-beating-heart-totally-endoscopic-coronary-artery-bypass-feasible-for-bmi-35-morbidly-obese-patients
#11
Hiroto Kitahara, Brooke Patel, Mackenzie McCrorey, Sarah Nisivaco, Husam H Balkhy
BACKGROUND: We investigated the outcomes of morbidly obese patients after robotic beating heart totally endoscopic coronary artery bypass (BH-TECAB). METHODS: This is a retrospective single center study. From July 2013 to December 2016, the outcomes of patients undergoing BH-TECAB were reviewed. RESULTS: A total of 234 patients underwent BH-TECAB (172 male, mean age 65.2 years). There were 43 morbidly obese patients defined as body mass index (BMI) greater than 35, and 191 non-morbidly obese patients...
April 23, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29663328/gamma-aminobutyric-acid-agonists-for-antipsychotic-induced-tardive-dyskinesia
#12
REVIEW
Samer Alabed, Youssef Latifeh, Husam Aldeen Mohammad, Hanna Bergman
BACKGROUND: Chronic antipsychotic drug treatment may cause tardive dyskinesia (TD), a long-term movement disorder. Gamma-aminobutyric acid (GABA) agonist drugs, which have intense sedative properties and may exacerbate psychotic symptoms, have been used to treat TD. OBJECTIVES: 1. Primary objectiveThe primary objective was to determine whether using non-benzodiazepine GABA agonist drugs for at least six weeks was clinically effective for the treatment of antipsychotic-induced TD in people with schizophrenia, schizoaffective disorder or other chronic mental illnesses...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29652095/decrease-in-neprilysin-and-vasoconstrictors-and-increase-in-vasodilators-following-bariatric-surgery
#13
Husam Ghanim, Scott Monte, Joseph Caruana, Kelly Green, Sanaa Abuaysheh, Paresh Dandona
Since morbid obesity is associated with congestive cardiac failure and hypertension, and gastric bypass surgery is followed by a reduction in blood pressure and in the risk of congestive cardiac failure, we hypothesized that weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of renin angiotensin system (RAS), catecholamines and endothelin-1 with an increase in the concentrations of vasodilators...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29629325/the-antiplaque-efficacy-of-two-herbal-based-toothpastes-a-clinical-intervention
#14
Sudhir Rama Varma, Husam Sherif, Ahmed Serafi, Salim Abu Fanas, Vijay Desai, Eiyas Abuhijleh, Ahmad Al Radaidah
Aims: This study is the first of its kind in the United Arab Emirates, where these herbal plant extracts are commonly incorporated into toothpaste. The present study compares two herbal toothpastes (Meswak extract and tea tree oil [TTO]) and analyses their efficiency in reducing plaque accumulation. Materials and Methods: A total of 25 patients were examined for plaque and assigned a plaque score. They were then randomly assigned to use either Meswak-based toothpaste or TTO-based toothpaste...
January 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29624367/large-dielectric-constant-enhancement-in-mxene-percolative-polymer-composites
#15
Shaobo Tu, Qiu Jiang, Xixiang Zhang, Husam N Alshareef
We demonstrate that poly(vinylidene fluoride) (PVDF)-based percolative composites using two-dimensional (2D) MXene nanosheets as fillers exhibit significantly enhanced dielectric permittivity. The poly(vinylidene fluoride-trifluoro-ethylene-chlorofluoroehylene) (P[VDF-TrFE-CFE]) polymer embedded with 2D Ti3 C2 Tx nanosheets reaches a dielectric permittivity as high as 105 near the percolation limit of about 15.0 wt % MXene loading, which surpasses all previously reported composites made of carbon-based fillers in the same polymer...
April 6, 2018: ACS Nano
https://www.readbyqxmd.com/read/29600447/measurements-of-intra-oocyte-nitric-oxide-concentration-using-nitric-oxide-selective-electrode
#16
Sana N Khan, Roohi Jeelani, Husam M Abu-Soud
Precise information about the intracell nitric oxide (NO) concentration [NO] of a single cell are necessary in designing accurate experiments to further knowledge and develop treatment plans in certain disorders. The direct quantitative measurement of [NO] in situ in an intact cellular complex should be useful in tracking real-time and rapid changes at nanomolar levels. In this work, we describe the direct, real-time, and quantitative intracellular [NO] measurement utilizing an L-shaped amperometric integrated NO-selective electrode...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29561210/preparation-and-characterization-of-letrozole-loaded-poly-d-l-lactide-nanoparticles-for-drug-delivery-in-breast-cancer-therapy
#17
Bayan Alemrayat, Abdelbary Elhissi, Husam M Younes
Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism, and a range of side effects. In this study, polymer-based nanoparticles (NPs) incorporating the drug have been designed and characterized, aimed to control the release, potentially maximize the therapeutic efficiency, and minimize the side effects of the drug. LTZ was incorporated into poly(d,l-lactide) (PDLLA) NPs by employing the emulsion-solvent evaporation technique using a range of drug concentrations...
April 5, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29553411/quality-of-life-primary-traumatisation-and-positive-and-negative-affects-in-primary-school-students-in-the-gaza-strip
#18
Guido Veronese, Alessandro Pepe, Feda Almurnak, Alaa Jaradah, Husam Hamdouna
BACKGROUND: Many researchers have reported that exposure to war and ongoing political violence increases mental health problems in children. Results of studies have also shown a high prevalence (58-80%) of post-traumatic stress disorder in war-affected children living in the occupied Palestinian territory. The aim of this study was to estimate the direct and indirect effects of perceived life satisfaction on the consequences of children's exposure to trauma and the balance of positive and negative affect...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29546341/letter-to-the-editor-long-term-testosterone-administration-on-insulin-sensitivity-in-older-men-with-low-or-low-normal-testosterone-levels
#19
Sandeep Dhindsa, Husam Ghanim, Paresh Dandona
No abstract text is available yet for this article.
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29531797/aspergillus-spinal-epidural-abscess-case-presentation-and-review-of-the-literature
#20
Faris Shweikeh, Stephanie Zyck, Fadi Sweiss, Ajleeta Sangtani, Mohammed Shweikeh, Husam Issa, Michael P Steinmetz, Georges Z Markarian
Study design: In this review, we present a case of Aspergillus spinal epidural abscess (ASEA) and review the literature. Objectives: To provide further insight on a rare condition. Setting: A description of a patient with ASEA in a 58-year-old woman that was successfully treated with conservative management is presented. Methods: Following case presentation, a literature search (MedLine and PubMed) and assessment of epidemiology, presentation, diagnosis, treatments, and outcomes is performed...
2018: Spinal Cord Series and Cases
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