Novel

BACKGROUND: In mechanical thrombectomy for tandem occlusions in vertebrobasilar stroke, distal emboli from the vertebral artery lesion should be prevented. However, no suitable embolic protection devices are currently available in the posterior circulation. Here, the authors describe the case of a vertebral artery lesion effectively treated with a closed-tip stent retriever as an embolic protection device in the posterior circulation. OBSERVATIONS: A 65-year-old male underwent mechanical thrombectomy for basilar artery occlusion, with tandem occlusion of the proximal vertebral artery...

Acetylcholinesterase (AChE) inhibition by organophosphorus (OP) compounds poses a serious health risk to humans. While many therapeutics have been tested for treatment after OP exposure, there is still a need for efficient reactivation against all kinds of OP compounds, and current oxime therapeutics have poor blood-brain barrier penetration into the central nervous system, while offering no recovery in activity from the OP-aged forms of AChE. Herein, we report a novel library of 4-amidophenol quinone methide precursors (QMP) that provide effective reactivation against multiple OP-inhibited forms of AChE in addition to resurrecting the aged form of AChE after exposure to a pesticide or some phosphoramidates...

The application of proteomic analysis to forensic skeletal remains has gained significant interest in improving biological and chronological estimations in medico-legal investigations. To enhance the applicability of these analyses to forensic casework, it is crucial to maximize throughput and proteome recovery while minimizing interoperator variability and laboratory-induced post-translational protein modifications (PTMs). This work compared different workflows for extracting, purifying, and analyzing bone proteins using liquid chromatography with tandem mass spectrometry (LC-MS)/MS including an in-StageTip protocol previously optimized for forensic applications and two protocols using novel suspension-trap technology (S-Trap) and different lysis solutions...

Many patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for preventing and treating glucocorticoid-induced osteoporosis...

Invited for the cover of this issue are Harmeet Bhoday, Nathan Knotts, and Rainer Glaser at the Missouri University of Science and Technology. Joe Miner, the university mascot, is a silent and honorary co-author and personifies the spirit of the old west and the determination to succeed (our emphasis). The image depicts one (MeO-Ph, Y)-azine molecule and a model of a perfectly polar stacked bilayer. The floodlight illumination presents a graphic metaphor of second-harmonic generation (frequency doubling) by the crystalline ferroelectric materials...

Single-molecule imaging at the tissue scale has revolutionized our understanding of biology by providing unprecedented insight into the molecular expression of individual cells and their spatial organization within tissues. However, achieving precise image stitching at the single-molecule level remains a challenge, primarily due to heterogeneous background signals and dim labeling signals in single-molecule images. This paper introduces Spot-Based Global Registration (SBGR), a novel strategy that shifts the focus from raw images to identified molecular spots for high-resolution image alignment...

The advent of immune checkpoint blockade therapy has revolutionized cancer treatments and is partly responsible for the significant decline in cancer-related mortality observed during the last decade. Immune checkpoint inhibitors, such as anti-programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1), have demonstrated remarkable clinical successes in a subset of cancer patients. However, a considerable proportion of patients remain refractory to immune checkpoint blockade, prompting the exploration of mechanisms of treatment resistance...

The development of catalysts for controlled fragmentation of proteins is a critical undertaking in modern proteomics and biotechnology. {Zr6 O8 }-based metal-organic frameworks (MOFs) have emerged as promising candidates for catalysis of peptide bond hydrolysis due to their high reactivity, stability, and recyclability. However, emerging evidence suggests that protein hydrolysis mainly occurs on the MOF surface, thereby questioning the need for their highly porous 3D nature. In this work, we show that the discrete and water-soluble [Zr6 O4 (OH)4 (CH3 CO2 )8 (H2 O)2 Cl3 ]+ (Zr6 ) metal-oxo cluster (MOC), which is based on the same hexamer motif found in various {Zr6 O8 }-based MOFs, shows excellent activity toward selective hydrolysis of equine skeletal muscle myoglobin...

A novel iridium(III) photosensitizer containing pyridinium-decorated terpyridines has been used for the photo-oxidation of chloride in water. Despite its abundance, the very positive one-electron reduction potential ( E ° Cl•/- = 2.1-2.4 V vs NHE) restricted its use in energy conversion schemes and artificial photosynthesis. The kinetics of the photoinduced electron transfer process were investigated through Stern-Volmer quenching experiments and nanosecond transient absorption spectroscopy, which provided unambiguous evidence that photoinduced chloride oxidation occurred with a quenching rate constant k q = 5...

This feasibility study reports on the development and initial evaluation of a novel online intervention for helping professionals (HPs; i.e. mental health professionals, chaplains, clergy) designed to (a) address occupational hazards, such as burnout and vicarious traumatization, and (b) promote well-being and flourishing at work. In contrast with competency and self-care focused models, the CHRYSALIS (Catalyzing Helping Professionals' Resilience, VitalitY, Spirituality, Authentic Living, and Inner Strength) intervention centers the self of the provider, explores cultural and spiritual contexts, and attends to systemic challenges...

A novel TT-type resonator was proposed for the first time, to our knowledge, to realize differential photoacoustic (PA) detection for trace gas measurement. The special design of the TT-type resonator allows us to install the microphone at the resonant center of the acoustic field to maximize the use of the absorption-induced PA signal. To meet the requirement of low gas consumption and easy integration, the TT-type resonator-based PA cell was fabricated as a fiber-coupled module with an inner volume of only 1...

A novel, to the best of our knowledge, Tm,Ho:GdScO3 crystal grown using the Czochralski method was investigated for its polarized spectroscopic properties and laser performance in both tunable continuous-wave (CW) and mode-locked regimes. The crystal's multisite structure (Gd3+ /Sc3+ site) and Tm3+ /Ho3+ dopants contributed to spectral broadening, enabling a tunable laser operation from 1914 to 2125 nm (with a broad range of 215 nm). Additionally, a pulse duration of 72 fs was achieved for E || b polarization...

The characterization of inverted structures (crystallographic, ferroelectric, or magnetic domains) is crucial in the development and application of novel multi-state devices. However, determining these inverted structures needs a sensitive probe capable of revealing their phase correlation. Here a contrast-enhanced phase-resolved second harmonic generation (SHG) microscopy is presented, which utilizes a phase-tunable Soleil-Babinet compensator and the interference between the SHG fields from the inverted structures and a homogeneous reference...

Focused laser differential interferometry (FLDI) is an important diagnostic for measuring density fluctuations in high-speed flows. Currently, however, high dynamic range FLDI is limited to photodiode measurements. In order to spatially resolve multiple locations within complex flows, we present a novel, to the best of our knowledge, refractive-optic imaging FLDI concept that not only produces two-dimensional images without scanning but also reduces the measurement noise floor of those images. To demonstrate this concept, a 33 × 33 grid of FLDI points is first generated using a microlens array...

Controlling the properties of mid- and far-infrared radiation can provide a means to transiently alter the properties of materials for novel applications. However, a limited number of optical elements are available to control its polarization state. Here we show that a 15-µm thick liquid crystal cell containing 8CB (4-octyl-4'-cyanobiphenyl) in the ordered, smectic A phase can be used as a phase retarder or wave plate. This was tested using the bright, short-pulsed (∼1 ps) radiation centered at 16...

Plasmonic nanosensors and the dynamic control of light fields are of the utmost significance in the field of micro- and nano-optics. Here, our study successfully demonstrates a plasmonic nanosensor in a compact coupled resonator system and obtains the pressure-induced transparency phenomenon for the first time to our knowledge. The proposed structure consists of a groove and slot cavity coupled in the metal-insulator-metal waveguide, whose mechanical and optical characteristics are investigated in detail using the finite element method...

The emerging field of optical vortex beams having fractional topological charges (TCs) is of high interest due to its usefulness in various applications. The efficiency of the result depends on the precise measurement of the orbital angular momentum information tied to the fractional TC. This Letter demonstrates, to our knowledge, a novel and simple technique to measure the fractional TC of optical vortex beams through a hybrid digital-optical correlator with the help of auto-correlation between fork-shaped interference patterns corresponding to integer and fractional TCs...

This Letter proposes a novel, to the best of our knowledge, coded modulation scheme for randomly coupled multi-core fiber (RC-MCF) via multidimensional (MD) constellation with concatenated two-level multilevel coding (MLC). In the proposed system, the 16-dimensional (16D) Voronoi constellation (VC), naturally fitting with the 16 degrees of freedom of a four-core fiber (two quadratures, two polarizations, and four cores), is generated by a latticed-based shaping method to provide higher shaping gains. Moreover, combining it with the concatenated two-level MLC can further achieve better performance-complexity trade-off...

Unsupervised spectral reconstruction (SR) aims to recover the hyperspectral image (HSI) from corresponding RGB images without annotations. Existing SR methods achieve it from a single RGB image, hindered by the significant spectral distortion. Although several deep learning-based methods increase the SR accuracy by adding RGB images, their networks are always designed for other image recovery tasks, leaving huge room for improvement. To overcome this problem, we propose a novel, to our knowledge, approach that reconstructs the HSI from a pair of RGB images captured under two illuminations, significantly improving reconstruction accuracy...

Inherent periodic collisions in dual-wavelength mode-locked fiber lasers (MLFLs) stimulate various intra-cavity collision dynamic phenomena. Analogous to the collision of matter particles, collisions between optical soliton molecules (SMs) and single solitons (SSs) have been observed by the real-time spectral measurements. It is demonstrated that the energy accumulation after the collision caused by internal motion within bound pulses leads to soliton pair (SP) explosions, while the periodic soliton explosions with another cavity parameter setting are almost unaffected by the collision...